Improving Sleep in Veterans With the Polytrauma Clinical Triad
NCT06477796
Recruiting
The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain. Veterans with the PCT are medically complex, often refractory to conventional therapies, and suffer from additional related chronic sequela. Notably, sleep disturbances and cognitive impairment, which the investigators hypothesize are significant contributing factors to these functional impairments and an im... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
06/23/2025
Locations: VA Portland Health Care System, Portland, OR, Portland, Oregon
Conditions: Traumatic Brain Injury, Post-traumatic Stress Disorder, Chronic Pain
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A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma
NCT06485778
Recruiting
This study will test whether limiting standard photon intensity modulated radiation therapy (IMRT) to exclude the oral tongue surgical site can decrease the risk of side effects caused by oral radiation. The researchers will also find out if this approach affects the rate of disease coming back after treatment (recurrence), and will measure participants' quality of life by having them complete questionnaires.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey +6 locations
Conditions: Oral Tongue Squamous Cell Carcinoma
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Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)
NCT06486441
Recruiting
The goal of this clinical study is to find out how the study drug, sacituzumab govitecan (SG) works in participants with endometrial cancer who have received prior treatment with platinum-based chemotherapy and immunotherapy, versus the treatment of physician's choice (TPC). The primary objectives of this study are to evaluate the effect of SG compared to TPC on progression-free survival (PFS) as assessed by blinded independent central review (BICR) and overall survival (OS).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +170 locations
Conditions: Endometrial Cancer
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Targeted Investigation of Microbiome 2 Treat Atopic Dermatitis (TIME-2)
NCT06504160
Recruiting
This is a Phase 1b, randomized, placebo/vehicle-controlled, double-blinded, multi-center trial. It is designed to assess the safety and efficacy of S. hominis A9 (ShA9) topical application as a treatment for atopic dermatitis (AD). The trial will enroll adults and adolescents with atopic dermatitis who are culture positive for S. aureus colonization. The primary safety objective of this study is to compare the safety profile of ShA9 to placebo (vehicle) over 14 weeks of application, which inclu... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
06/23/2025
Locations: University of California, San Diego: Dermatology Clinical Trials Unit, San Diego, California +7 locations
Conditions: Atopic Dermatitis
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Visual-acoustic Intervention With Service Delivery In-person and Via Telepractice Trial
NCT06517225
Recruiting
Children with speech sound disorder show diminished intelligibility in spoken communication and may thus be perceived as less capable than peers, with negative consequences for both socioemotional and socioeconomic outcomes. New technologies have the potential to transform interventions for speech sound disorder, but there is a lack of rigorous evidence to substantiate this promise. This research will meet a public health need by systematically evaluating the efficacy of visual-acoustic biofeedb... Read More
Gender:
FEMALE
Ages:
Between 9 years and 17 years
Trial Updated:
06/23/2025
Locations: Montclair State University, Bloomfield, New Jersey +2 locations
Conditions: Speech Sound Disorder
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The Hastiin Bidziil (Strong Man) Intervention
NCT06559774
Recruiting
The Hastiin Bidziil (Strong man) Intervention study is part of a larger project called, Community-Driven Indigenous Research, Cultural Strengths \& Leadership to Advance Equity in Substance Use Outcomes (CIRCLE) Center of Excellence. CIRCLE aims to address drug use related health problems in collaboration with diverse Indigenous communities. This study is a randomized controlled trial study to measure the effectiveness of a secondary prevention program, called Hastiin Bidziil (Strong Man), aimed... Read More
Gender:
MALE
Ages:
Between 18 years and 26 years
Trial Updated:
06/23/2025
Locations: Navajo Nation Center for Indigenous Health - Chinle, Chinle, Arizona +1 locations
Conditions: Substance Use
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eMOTION: Examining Affective Mechanisms in Physical Activity Engagement
NCT06570642
Recruiting
This early-phase trial will test intervention strategies to influence affective mechanisms underlying physical activity and determine whether changes in those mechanisms result in change in physical activity behavior among inactive adults who are overweight or obese.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Physical Inactivity, Overweight or Obesity, Cancer
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An Open-Label Treatment With Randomization Observation, Investigator-Initiated Study, on the Duration and Efficacy of Jornay PM (Methylphenidate Hydrochloride Extended-Release Capsules) on Adult ADHD Symptoms and Executive Function and Emotional Regulation Throughout the Day Into Early Evening
NCT06577779
Recruiting
The goal of this study is to extend the efficacy evidence of sustained release methylphenidate compound (JornayPM) in adults with Attention-deficit/hyperactivity disorder (ADHD). JornayPM has recently been approved for treatment of patients 6 years and older with ADHD; the release mechanism is unique among ADHD products in that it is taken in the evening, with effects in the morning upon awakening and then throughout the subsequent day. Of note, to date, there is no clinical data as to the toler... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/23/2025
Locations: NYU Langone Health, New York, New York
Conditions: Attention-deficit/Hyperactivity Disorder
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Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)
NCT06587230
Recruiting
Purpose: The purpose of this research is to pilot test a novel, alternative, potentially sustainable system of teacher-delivered, task-shifted child mental health care. Participants: \~300 estimated Procedures: This is a RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) guided, mixed methods, clustered evaluation of Tealeaf-NC's Reach, Adoption \& Implementation (Primary Outcomes, implementation-based), as well as evaluating for preliminary indicators of Effectiveness \& Mai... Read More
Gender:
ALL
Ages:
Between 5 years and 99 years
Trial Updated:
06/23/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Child Behavior, Mental Health Issue, Psychosocial Functioning, Depression, Anxiety
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Clinical Readiness Skin Punch Biopsy Sample Collections
NCT06588426
Recruiting
This is a clinical readiness skin punch biopsy sample collection study. This will allow to reduce manufacturing time when patients are identified as eligible to receive product under separate interventional treatment protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Congenital Heart Disease (CHD), Congenital Heart Defect
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Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels
NCT06597149
Recruiting
The purpose of this study is to find out if investigators can stimulate the vagus nerve (a nerve in the body that runs from your brain to the large intestine), and influence insulin, C-peptide, and glucose levels. C-peptide is a substance that is created when insulin is produced and released into the body. The vagus nerve is a largely internal nerve that controls many bodily functions, including stomach function. Investigators hope that by stimulating the vagal nerve using the TeNS behind the e... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/23/2025
Locations: Indiana University Hospital, Indianapolis, Indiana
Conditions: Healthy
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Impact of Daily Oral Cannabis Doses in Patients With Cancer
NCT06601218
Recruiting
This study will enroll patients with cancer and participants will be randomized to receive one dose of cannabis for approximately 4 months. There is a 3/4 (or 75%) chance that a participant will receive an active cannabis dose in the study. There is a 1/4 (or 25% chance) that a participant will receive a placebo dose (meaning a blank dose/no cannabis/no active drug). The goals of this study are to determine 1) the safety and tolerability of cannabis in individuals with cancer and 2) if cannabis... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Cancer, Cancers, Pain
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