Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain
NCT06229470
Recruiting
The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Lakeside Spine and Pain, Lake Havasu City, Arizona +24 locations
Conditions: Chronic Pain
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AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
NCT06346392
Recruiting
The purpose of this study is to measure the efficacy and safety of AZD0901 compared to Investigator's choice of therapy as 2L+ treatment for participants with advanced or metastatic gastric or GEJ adenocarcinoma expressing CLDN18.2.
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
03/03/2025
Locations: Research Site, Birmingham, Alabama +179 locations
Conditions: Gastric Cancer, Gastroesophageal Junction Cancer
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Sleep Restriction and Parental History of Hypertension
NCT06482814
Recruiting
The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
03/03/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Hypertension
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A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients with Neurofibromatosis Type 1
NCT06541847
Recruiting
The trial will be an open label, single arm, phase 2 study in 20 participants. The study will assess the tolerability and efficacy of HLX-1502 in participants with NF1 16 years of age or older with progressive and/or symptomatic PN.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
03/03/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +3 locations
Conditions: Neurofibromatosis Type 1
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Multicomponent Intervention Study- Blood Donors With High Cholesterol
NCT05693701
Recruiting
The purpose and objective of this study is to improve cholesterol treatment among blood donors with FH (Familial Hypercholesterolemia).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/02/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Lipid Metabolism Disorder
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Early Versus Delayed Bathing of Orthopaedic Surgical Wounds
NCT06014411
Recruiting
This is a single center randomized control trial assessing the effect of early versus delayed bathing on orthopaedic surgical wounds in patients undergoing surgical treatment of fractures. Patients will be recruited by screening all patients undergoing surgical treatment for fractures at our institution. Patients who provide written consent will be randomized to one of two treatment arms after confirming eligibility criteria. Group A will be advised to begin early normal bathing (non-submerged s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/02/2025
Locations: NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York
Conditions: Surgical Wound, Post Operative Wound Infection
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New Investigational Stimulation Protocol for Treatment of Major Depression Disorder (MDD)
NCT06357832
Recruiting
The BrainsWay Deep Transcranial Magnetic Stimulation (Depp TMS) device is intended for the treatment of depressive episodes in patients suffering from Major Depressive Disorder (MDD). The device technology is based on the application of deep brain TMS by means of repetitive pulse trains at a determined frequency. The purpose of the current study is to evaluate the safety and effectiveness of a new investigational stimulation protocol delivered with the BrainsWay Deep TMS device, for the treatmen... Read More
Gender:
ALL
Ages:
Between 22 years and 68 years
Trial Updated:
03/02/2025
Locations: Novus Neurology, Tuscaloosa, Alabama +8 locations
Conditions: Major Depressive Disorder
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A Single-center, Open-label, Study Evaluating Safety and Pharmacokinetics of Single Doses of Zidebactam-Cefepime and Metronidazole Alone or in Combination.
NCT06806995
Recruiting
This is a Phase I, Single-Center, Open-Label study evaluating the safety and pharmacokinetics of single doses of ZID-FEP and metronidazole alone or in combination utilizing a 3-period, crossover study design. Thirty eligible male and female healthy adult subjects will participate in the study and receive single doses of (1) ZID-FEP 3g IV (ZID 1 g plus FEP 2 g) administered over 1 hour (h); (2) metronidazole 0.5 g IV alone administered over 1 h; and (3) metronidazole 0.5 g IV over 1 h, followed b... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
03/02/2025
Locations: Advanced Pharma CR, LLC, Miami, Florida
Conditions: PHA1A
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The Impact of Biophoton Therapy on Self-Grown Stem Cells
NCT06855459
Recruiting
Study Objective The purpose of this clinical study is to evaluate if biophoton therapy, delivered by Tesla BioHealing® Biophoton Generators (Biophotonizer), can increase self-grown stem cells naturally. Study Design This is a randomized, double-blinded, placebo-controlled intervention clinical study to assess the effectiveness of biophoton therapy in impacting stem cells. Approximately 46 volunteers who want to increase self-grown stem cells will participate in the study. Study Randomization T... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/02/2025
Locations: Tesla MedBed at Tampa-FL, Tampa, Florida +1 locations
Conditions: Increase the Total Number of Stem Cells, Inflammation
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Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
NCT04237701
Recruiting
The Yale HF Registry is a live EHR based registry that allows for retrospective and real-time monitoring of Heart Failure case across the Yale New Haven Health System.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/02/2025
Locations: Yale New Haven Health System, New Haven, Connecticut
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Heart Failure NYHA Class IV
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A Study of NB004 As Monotherapy or Combination Therapy in Patients with Advanced Solid Tumors
NCT05036291
Recruiting
This is a Phase 1, Open-label, Multicenter Study to Assess the Safety, Tolerability, and Pharmacokinetics of NB004 Administered as Monotherapy or Combination Therapy in Subjects with Advanced Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/02/2025
Locations: LSU-LCMC Health Cancer Center, New Orleans, Louisiana +3 locations
Conditions: Advanced Solid Tumor
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Cervical Plexus Hydrodissection With D5W for PTSD
NCT04421573
Recruiting
PTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and observational results have shown it to be effective in reducing anxiety, brain fog, and depression in patients with PTSD. This randomized trial will compare dextrose injection with a delayed/usual treatment control.
Gender:
ALL
Ages:
Between 19 years and 90 years
Trial Updated:
03/01/2025
Locations: Hawaii Center for Regenerative Medicine, Hilo, Hawaii +6 locations
Conditions: PTSD
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