Study of ICG Fluorescence Imaging in Open Fracture and Infection Patients
NCT06793644
Recruiting
The purpose of this study is to determine whether an indocyanine green (ICG) fluorescence imaging system (cBPI) can be used to provide surgeons with information about bone health or bone blood flow. This will help surgeons better understand the healing potential of bone and relative risk of complication. This is important to help surgeons select the most appropriate treatment for severe traumatic injuries and infections.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2025
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Fractures, Bone, Trauma Injury
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H5N1 Milk Detection Study
NCT06850298
Recruiting
The purpose of this study is to determine whether drinking pasteurized milk (milk heated to kill harmful germs) that contains inactive particles of a flu virus called A(H5) could lead to the detection of the virus in the nose or throat. Inactive particles are not capable of causing disease. The results will help the Centers for Disease Control and Prevention (CDC) better understand how milk consumption could affect flu surveillance. Investigators also want to see if the body produces antibodies... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
06/17/2025
Locations: Hope Clinic, Atlanta, Georgia
Conditions: Influenza
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A Study of Oral E1018 in Healthy Adult Participants
NCT06854042
Recruiting
The primary purpose of the study is to evaluate the safety and tolerability of single ascending oral doses of E1018 in healthy adult participants and to evaluate the pharmacokinetics (PK) of E1018 in plasma and urine after single oral dose administration.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/17/2025
Locations: PPD Development, LP, Austin, Texas
Conditions: Malaria, Healthy Participants
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Bioimpedance for Ortho Trauma
NCT06858488
Recruiting
Patients with high-energy extremity trauma will undergo imaging with an EIT device in the Emergency Department, Operating Room, Orthopaedic Clinic, and In-patient hospital rooms. The EIT device is an electrical impedance tomography system.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2025
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Trauma Injury
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Study of ABX-002 for the Adjunctive Treatment of Depressive Episodes Associated With Bipolar Disorder in Adults
NCT06869187
Recruiting
The goal of this clinical trial is to learn if ABX-002 added to participants' existing treatment(s) shows effects on brain chemistry that may correlate with antidepressive effects. This is a single treatment arm, open-label, Phase 2 study of ABX-002 in 30 adults with bipolar depression. Five healthy volunteer participants will also be enrolled and receive no drug treatment, undergoing 2 imaging sessions to confirm instrument and test - retest method reliability control. For bipolar disorder pa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/17/2025
Locations: Autobahn Site #201, Cromwell, Connecticut +5 locations
Conditions: Bipolar Disorder Depression
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A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic Arthritis
NCT06869551
Recruiting
The purpose of this study is to evaluate the drug levels, efficacy, and safety of Deucravacitinib (BMS-986165) in pediatric participants with juvenile psoriatic arthritis.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
06/17/2025
Locations: Local Institution - 0038, Lancaster, California +41 locations
Conditions: Juvenile Psoriatic Arthritis
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Patient Perceptions and Experiences Following Multiple Sessions of Simulated or Genuine HVLA Manual Chiropractic Adjustments
NCT06931600
Recruiting
Our primary aim with this trial is to measure participant blinding following two simulated/sham or genuine/real high velocity, low amplitude (HVLA) manual chiropractic adjustments to assess if participants are able to identify their un-disclosed treatment group. Our secondary aims with this trial are to utilize electrocardiography (ECG), impedance cardiography (ICG), and gait analysis before either treatment session and after both treatment sessions to assess if there are any changes with the pa... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/17/2025
Locations: Dr. Sid E. Williams Center for Chiropractic Research, Marietta, Georgia
Conditions: Subluxation
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Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
NCT06941389
Recruiting
The WeDecide study is a large observational study comparing the long-term effects of matched related donor hematopoietic stem cell transplantation (MRD HCT) and non-transplant disease-modifying therapies (NT-DMT) for pediatric patients with sickle cell disease (SCD). The study aims to assess health-related quality of life (HRQoL), cognitive function, risks, and benefits of both treatments, including survival rates, chronic complications, and organ damage prevention. With 160 children in the MRD... Read More
Gender:
ALL
Ages:
Between 3 years and 20 years
Trial Updated:
06/17/2025
Locations: Children's of Alabama (MRD-HCT), Birmingham, Alabama +36 locations
Conditions: Sickle Cell Disease (SCD)
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Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults
NCT06942351
Recruiting
The purpose of this study is to examine the impact of daily consumption of walnuts for 12 weeks on cognitive function, markers of inflammation and oxidative stress, and the gut microbiome in healthy adults age 55 years and older.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
06/17/2025
Locations: Oregon State University, Corvallis, Oregon
Conditions: Aging, Inflammation Biomarkers
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Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)
NCT06962332
Recruiting
The primary purpose of this study is to evaluate the plasma PK of zanzalintinib following a single dose in participants with moderate liver dysfunction compared to matched healthy participants with normal liver function.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/17/2025
Locations: Exelixis Clinical Site #1, Orlando, Florida +1 locations
Conditions: Hepatic Impairment, Moderate Hepatic Impairment
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Sleep TO Prevent Post-surgical Pain
NCT06976138
Recruiting
This research study is being done to compare different methods of addressing sleep problems before total knee replacement surgery. These methods include Cognitive Behavioral Therapy and light exposure.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
06/17/2025
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland +1 locations
Conditions: Knee Osteoarthristis
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Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults
NCT07005505
Recruiting
For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2025
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Spontaneous Breathing Trial in ICU
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