Emergency Preparedness for Caregivers of Persons With Dementia: Disaster PrepWise
Recruiting
Individuals with dementia and their families are especially vulnerable during a disaster as it limits caregivers' ability to continue with care due to disaster related stress and reduced access to resources and support. The COVID-19 pandemic showed the extreme vulnerability of persons with dementia (PWD) and their caregivers as they struggled to access support and resources due to the threat of COVID-19 infection; such impact was exacerbated in rural areas where caregivers are geographically iso... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Caregiver Resilience and Stress
Effects of CBD/CBD-A Oral Extract on Resting-state EEG and Neuropathic Pain Symptoms After SCI
Recruiting
The main purposes of this study are to (1) measure the effect of CBD/CBD-A on pain symptoms, pain intensity, pain unpleasantness, and skin sensitivity to hot and cold temperatures; and (2) measure the effect of CBD on brain electrical activity with electroencephalography (EEG).
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
06/16/2025
Locations: Lynn Rehabilitation Center, Miami, Florida
Conditions: SCI - Spinal Cord Injury, Neuropathic Pain
Change in MAPSE During Treatment of Sepsis
Recruiting
Patients with bloodstream infections (sepsis) have been found in prior studies to have infection-related heart dysfunction, even if they did not have preexisting heart problems. Factors related to the infection may cause the heart to not pump as well as it should, causing critical illness in the form of low blood pressure (shock) and heart failure. Ultrasound is frequently used in the emergency department to evaluate why a patient might have low blood pressure. Part of that evaluation may includ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Sepsis
Estrogen Hormone Products
Recruiting
The purpose is to determine if the two estradiol products can deliver similar amounts of estradiol after single and multiple dosing.
Gender:
FEMALE
Ages:
Between 45 years and 65 years
Trial Updated:
06/16/2025
Locations: General Clinical Research Center (GCRC) at the University of Maryland Medical Center, Baltimore, Maryland
Conditions: Menopause
Investigating the Effects of Cannabidiol on Social Anxiety Disorder
Recruiting
The purpose of this study is to test whether a single-dose of Epidiolex (cannabidiol) is associated with reduced psychological, physiological, and neuroimaging measures of anxiety in people diagnosed with social anxiety disorder (SAD).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/16/2025
Locations: Massachusetts Institute of Technology, Cambridge, Massachusetts
Conditions: Phobia, Social
Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma
Recruiting
The purpose of this study is to compare how well tolerated and effective four different dosing schedules (two personalized, intermittent dosing schedules as compared to a fixed intermittent and continuous dosing regimen) work in people with advanced basal cell carcinoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Advanced Basal Cell Carcinoma
Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung Cancer
Recruiting
This study is an observational study of blood and tissue biomarkers. Investigators plan to evaluate the accuracy of lung cancer biomarkers found in the blood in determining if a lung nodule is cancer or benign. Investigators also plan to examine another biomarker found in the tumor tissue to identify participants after lung cancer surgery who have a high risk for recurrent cancer. Finally, investigators plan to determine if one of the blood-based biomarkers can be used to detect any late cancer... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Lung; Node, Adenocarcinoma of Lung
Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
Recruiting
COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: UCLA, Los Angeles, California +112 locations
Conditions: Acute Myocardial Infarction, Coronary Artery Disease
Double Voiding and Post-transplant UTI
Recruiting
Urinary tract infections (UTI) are common in kidney transplant recipients and are an important cause of illness and hospital admissions. Past studies have shown that about 1 out of 5 of newly transplanted patients develop UTI within their first 3 months of transplantation. Such UTIs increase the risk for blood stream infection and acute rejection of the kidney, Improvements in urinary voiding techniques may reduce the frequency of UTI. The purpose of this study is to evaluate the benefits of "do... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: Weill Cornell Medical College / NY Presbyterian, New York, New York
Conditions: Urinary Tract Infections, Kidney Transplant; Complications
Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced Unresectable or Metastatic HCC
Recruiting
The purpose of this study is to evaluate whether treatment with RP2 can provide efficacy as 2L treatment combined with atezolizumab plus bevacizumab in patients with locally advanced unresectable, recurrent, and/or metastatic HCC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: Beverly Hills Cancer Center, Beverly Hills, California +10 locations
Conditions: Hepatocellular Carcinoma
Clinical Validation of Samsung Smartwatch
Recruiting
Objective: Wearable technology holds promising potential for mental health monitoring and detection. Samsung has developed an algorithm that they believe can detect signs of depression and anxiety in smartwatch users. They have used this algorithm to create a "Mindfulness Index," which is an easily understood visual index of mental health. The primary aim of the study is to evaluate the performance of Samsung's Mindfulness Index in identifying those who have received a diagnosis of Major Depres... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/16/2025
Locations: Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Massachusetts
Conditions: Major Depressive Disorder, Mood Disorders, Mental Health Issue
CB-103 With Either Lenvatinib or Abemaciclib in Patients With NOTCH ACC
Recruiting
The goal of this study is to treat patients with NOTCH active advanced adenoid cystic carcinoma (ACC) tumors with a combination or two different oral medications to slow tumor growth and improve survival outcomes. The names of the study drugs involved in this study are: * CB-103 (an oral NOTCH pathway inhibitor) * Abemaciclib (CDK4/6 inhibitor) * Lenvatinib (a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI))
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Adenoid Cystic Carcinoma, Metastatic Adenoid Cystic Carcinoma, Recurrent Adenoid Cystic Carcinoma