A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia
NCT05865535
Recruiting
This open label ascending dose study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of AV-380 in cancer patients with Cachexia. AV-380 is an immunoglobulin (Ig) G1 monoclonal antibody (mAb) intended to bind circulating human growth differentiation factor 15 (GDF-15), a cytokine involved in cancer-induced cachexia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2025
Locations: Beverly Hills Cancer Center, Beverly HIlls, California +12 locations
Conditions: Cachexia
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Breathing Rescue for SUDEP Prevention
NCT05981755
Recruiting
The purpose of this study is to precisely delineate human brain networks that modulate respiration and identify specific brain areas and stimulation techniques that can be used to prevent seizure-induced breathing failure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2025
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Focal Epilepsy
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Roux-en-Y Gastric Bypass Versus Loop Gastrojejunostomy for Malignant Gastric Outlet Obstruction
NCT05986890
Recruiting
This study is intended to investigate whether roux-en-y bypass surgery is superior to conventional loop gastrojejunostomy for Malignant gastric outlet obstruction in terms of tolerance to solid food intake. We hypothesize that roux-en-y bypass will be associated with improved solid food intake in the first 30 days after surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2025
Locations: G. Paul Wright, Grand Rapids, Michigan
Conditions: Malignant Gastric Outlet Obstruction
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A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease
NCT05995353
Recruiting
Crohn's Disease (CD) is a gastrointestinal disease that can cause chronic diarrhea with or without gross bleeding, abdominal pain, weight loss, and fever. This study will assess the pharmacokinetics, efficacy, and safety of risankizumab in pediatric participants with moderately to severely active CD aged 2 to \< 18 years old who have had intolerance or inadequate response to other therapies. Risankizumab is an approved drug for adults with plaque psoriasis, psoriatic arthritis, and CD and is be... Read More
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
06/13/2025
Locations: Phoenix Children's Hospital /ID# 255766, Phoenix, Arizona +82 locations
Conditions: Crohn's Disease
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Safety and Feasibility of the ELIOS System in POAG Patients
NCT05999006
Recruiting
Evaluation of the safety and effectiveness of the ELIOS System procedure to reduce intraocular pressure (IOP) in adult subjects with mild to moderate primary open-angle glaucoma (POAG)
Gender:
ALL
Ages:
45 years and above
Trial Updated:
06/13/2025
Locations: Elios Vision Clinical Site, Glendale, Arizona +4 locations
Conditions: Glaucoma, Primary Open Angle
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REcovery From DEXmedetomidine-induced Unconsciousness
NCT06003127
Recruiting
This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) can be used to measure brain complexity during dexmedetomidine sedation without arousing study participants.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/13/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anesthesia, Healthy, Consciousness, Level Altered
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Non-invasive Brain Stimulation to Improve Unsteady Gait in Older Adults (StimGait)
NCT06008431
Recruiting
Walking is a complex and continuous task that entails repetitive motions of the body. Relatively high gait variability sensitively predicts falls and cognitive decline in older adults. Previous work has identified an unique brain network relationship linked to gait variability and its relevant cognitive function (i.e., sustained attention). This project aims to develop a non-invasive brain stimulation montage designed to modulate the shared brain networks dynamics and to demonstrate its effects... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
06/13/2025
Locations: Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts
Conditions: Fall, Gait, Unsteady, Mobility Limitation
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Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
NCT06016946
Recruiting
This project is a global, multicenter, prospective, longitudinal, observational natural history study that can be used to understand the disease progression and support the development of safe and effective drugs and biological products for Friedreich ataxia.
Gender:
ALL
Ages:
All
Trial Updated:
06/13/2025
Locations: UCLA Ataxia Center, Los Angeles, California +33 locations
Conditions: Friedreich Ataxia
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Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15
NCT06032026
Recruiting
The current protocol is to determine the biodistribution, metabolism, excretion and brain uptake of 11C HY-2-15. The goal of this radiotracer is to quantify alpha-synuclein that is abnormally deposited in the brain of people with Multiple System Atrophy (MSA). The investigators will compare uptake in people with MSA with people with Parkinson disease (PD) and progressive supranuclear palsy (PSP) as well as healthy volunteers. This multicenter project funded by an NIH U19 grant, is centered at U... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
06/13/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Tauopathies
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Does Social Media Impact Adolescent Mental Health?
NCT06049888
Recruiting
The mental health of adolescents in the United States has seen a steep decline since 2011, roughly coinciding with the increasing popularity of social media and smartphones. But does social media have a causal impact on the mental health of adolescents or are concerns about the effect of social media on kids a form of public hysteria? In this study, the investigators will conduct the first field experiment in 11-14-year-olds to examine whether, how, and for whom social media harms mental health.
Gender:
ALL
Ages:
Between 10 years and 14 years
Trial Updated:
06/13/2025
Locations: Georgetown University, Washington, District of Columbia
Conditions: Mental Health
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Early Feasibility Study (EFS) Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System
NCT06183684
Recruiting
The objective of the study is to assess the safety and technical feasibility of the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System
Gender:
ALL
Ages:
Between 22 years and 90 years
Trial Updated:
06/13/2025
Locations: Tucson Medical Center, Tucson, Arizona +5 locations
Conditions: Tricuspid Regurgitation
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S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP
NCT06188702
Recruiting
This is a first-in-human Phase 1/2, multicenter, open-label study of S095035 as single-agent, or in combination with TNG462 in adult participants with advanced or metastatic solid tumors with homozygous deletion of MTAP who have failed to respond to or have progressed after at least 1 prior treatment regimen, and for whom additional effective standard treatment is not available. S095035 is an oral methionine adenosyltransferase 2A \[MAT2A\] inhibitor. TNG462 is a protein arginine N-methyltransfe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2025
Locations: University of California Los Angeles, Los Angeles, California +32 locations
Conditions: MTAP-deleted Solid Tumors
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