A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer
NCT06568692
Recruiting
This is an adaptive Phase 2, open-label, randomized, multi-center study evaluating up to 2 regimens of PCS6422 with capecitabine (Cap) vs. standard dose of Cap alone in patients with advanced or metastatic breast cancer. The goal of the study is to assess the efficacy and safety of PCS6422 + Cap as a treatment option for patients with advanced or metastatic breast cancer who are not eligible for anthracycline- or taxane-containing therapies, or other available therapies, including PD-1 or PARP i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Arizona Oncology Associates, Tucson, Arizona +8 locations
Conditions: Breast Cancer, TNBC - Triple-Negative Breast Cancer, HER2-negative Breast Cancer
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Well-being Training for Adolescent Depressive Symptoms (TeenWell Study)
NCT06626425
Recruiting
This study is being done to see if the Healthy Minds Program app helps adolescents with elevated depressive symptoms. Up to 200 participants will be on study for 20 weeks.
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
02/24/2025
Locations: Center for Healthy Minds, University of Wisconsin Madison, Madison, Wisconsin
Conditions: Depression
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Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients
NCT06780202
Recruiting
This clinical trial aims to determine the effects of a 6-day low-dose methylprednisolone course on pain, nausea, and total opioid consumption in patients undergoing foot and ankle surgeries. The secondary objective of the study is to determine and monitor the effects of the course on complications following surgery and patient-reported outcomes
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
02/24/2025
Locations: Emory Musculoskeletal Institute, Emory Orthopaedics & Spine Center, Atlanta, Georgia +1 locations
Conditions: Foot Injuries and Disorders, Ankle Injuries and Disorders, Achilles Tendon Injury
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Pediatric Down Syndrome Post-Approval Study
NCT06851338
Recruiting
The purpose of this Post Approval research study is to assess ongoing safety and effectiveness of the Inspire therapy in adolescents and young adults (age 13-18) with Down syndrome and severe sleep apnea. The objective of the study is to provide an ongoing safety and effectiveness assessment of the Inspire UAS System in the Pediatric Down syndrome population.
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
02/24/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +5 locations
Conditions: Pediatric Obstructive Sleep Apnea, Down Syndrome (DS)
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Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT03516617
Recruiting
This phase II trials studies how well acalabrutinib with or without obinutuzumab works in treating patients with early-stage chronic lymphocytic leukemia or small lymphocytic lymphoma. Acalabrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known wh... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +2 locations
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
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Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests
NCT04125134
Recruiting
This is a single site, prospective, cross-sectional, controlled clinical study on a total of 66 subjects. The subjects are divided into two groups: Hypertonic Saline Non-Responders (33 subjects) and Hypertonic Saline Responders (33 subjects). After completion of questionnaires, the subjects will undergo Dry Eye Disease testing and functional nerve testing. Subjects who qualify will be dispensed 4 weeks of preservative free artificial tears and instructed to instill one drop into each eye twice d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Tufts Medical Center-New England Eye Center, Boston, Massachusetts
Conditions: Dry Eye
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CivaDerm(TM) Surface Therapy Pilot Study
NCT04480645
Recruiting
This is a pilot study to determine the usefulness of new brachytherapy device that utilizes active components (palladium-103) of standard devices in a novel configuration, which may benefit basal cell and squamous cell carcinoma patients by providing conformal radiation therapy to the surface of the skin.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: CivaDerm Oncology PLLC, Morrisville, North Carolina
Conditions: Basal Cell Carcinoma, Squamous Cell Carcinoma of the Skin
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A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer
NCT04683679
Recruiting
The purpose of this study is to find out whether adding pembrolizumab, with or without olaparib, to standard radiation therapy is a safe and effective treatment for metastatic breast cancer, , and to see whether the study treatment is better than, the same as, or worse than the usual approach (radiation therapy alone).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Triple Negative Breast Cancer, TNBC - Triple-Negative Breast Cancer, Breast Cancer, Metastatic Breast Cancer
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Psilocybin-facilitated Treatment for Chronic Pain
NCT05068791
Recruiting
The primary purpose of this study is to preliminarily estimate the efficacy of psilocybin-facilitated treatment for fibromyalgia. Investigators will assess the impact of psilocybin-facilitated treatment on pain, fatigue, and other fibromyalgia symptoms, in addition to the level of functioning and quality of life. Investigators will also evaluate potential mediators of treatment (e.g., treatment expectations, pain characteristics, personality, beliefs/cognitions, emotions). Investigators hypothes... Read More
Gender:
FEMALE
Ages:
Between 25 years and 65 years
Trial Updated:
02/24/2025
Locations: UAB Beacon Tower, Birmingham, Alabama
Conditions: Fibromyalgia, Primary
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In Vivo Detection of Circulating Clots in Patients With Thromboembolism
NCT05301348
Recruiting
Subjects with thromboembolic disease or at high-risk for thromboembolic conditions diagnosed with ultrasound or other standard of care techniques will be recruited to estimate the feasibility of a device to detect in vivo CBCs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Univerisity of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Thromboembolism
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A Comparison of the Outcomes in Fortiva and Strattice Mesh
NCT05572021
Recruiting
A comparison of ventral hernia repair with Strattice and Fortiva mesh.Primary The study team aims to determine the hernia recurrence rates for RTI Surgical biologic mesh (Fortiva) compared to Strattice. Also the study team aims to determine the mesh related complications for RTI Surgical biologic mesh (Fortiva) compared to Strattice
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/24/2025
Locations: Carolinas Medical Center, Charlotte, North Carolina
Conditions: Ventral Hernia
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MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions
NCT05908331
Recruiting
A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Superiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus- Coated Balloon in the Treatment of Coronary Drug-Eluting Stent In-Stent Restenosis. Subjects with prior DES implantation presenting with ISR lesions undergoing PCI will be randomized into two groups: treatment with the MagicTouch™ sirolimus-coated balloon or POBA on a 2:1 basis. Approximately 492 subjects will be enrolled in the randomized study in a... Read More
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
02/24/2025
Locations: Cardiology, PC - Princeton Baptist Medical Center, Birmingham, Alabama +27 locations
Conditions: In-Stent Restenosis, Cardiovascular Diseases, Coronary Artery Disease
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