Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
NCT05461326
Recruiting
The choice of autograft for ACL reconstruction continues to be debated. To date, there has only be one completed randomized controlled trial with quad tendon to BTB and the tendon included a bone plug. There has been no study to date comparing an all soft tissue quad tendon to patellar tendon in a randomized controlled trial for ACL reconstruction.
Gender:
ALL
Ages:
Between 14 years and 65 years
Trial Updated:
06/04/2025
Locations: UAB Hospital Highlands, Birmingham, Alabama
Conditions: Orthopedic Disorder, Anterior Cruciate Ligament Injuries
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Otoferlin Gene-mediated Hearing Loss Natural History Study
NCT05572073
Recruiting
This is a retrospective and prospective longitudinal study in participants with Otoferlin Gene-Mediated Hearing Loss.
Gender:
ALL
Ages:
44 years and below
Trial Updated:
06/04/2025
Locations: University of Iowa, Iowa City, Iowa +9 locations
Conditions: Sensorineural Hearing Loss, Bilateral
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Text Education About Cardiovascular Health and HIV (TEACH-HIV)
NCT05642858
Recruiting
The overall objective is to evaluate the efficacy of educational text messages to reduce cardiovascular risk among persons living with HIV (PLWH).
Gender:
ALL
Ages:
40 years and above
Trial Updated:
06/04/2025
Locations: Zuckerberg San Francisco General Hospital, San Francisco, California +1 locations
Conditions: HIV, Human Immunodeficiency Virus, Cardiovascular Diseases, Atherosclerosis
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XTX301 in Patients With Advanced Solid Tumors
NCT05684965
Recruiting
This is a first-in-human, multicenter, Phase 1/2, open-label study designed to evaluate the safety and tolerability of XTX301 as monotherapy in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: University of California, Davis Comprehensive Cancer Center, Sacramento, California +10 locations
Conditions: Advanced Solid Tumor
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A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments
NCT05714839
Recruiting
The study consists of two parts: Part 1 The primary purpose of this part aims to evaluate the safety, tolerability, and clinical activity of escalating doses of single agent belantamab in participants with refractory multiple myeloma (RRMM) who have received at least 3 prior therapies (4L+). Part 2 The primary purpose of this part is to evaluate the safety, tolerability, and clinical activity of different dose ratios of belantamab mafodotin in combination with belantamab (delivered as separate d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: GSK Investigational Site, Grand Rapids, Michigan +20 locations
Conditions: Multiple Myeloma
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Iscador® P (Mistletoe) Immunotherapy for Recurrent Osteogenic Sarcoma
NCT05726383
Recruiting
This will be a phase II, single arm study of osteosarcoma patients with fully resected pulmonary metastases. The MTD corresponds to the dosage recommendations of the manufacturer of Iscador® P which is licensed in Sweden, New Zealand, South Korea, Germany and Switzerland for the treatment of solid tumors and precancerous lesions. The study population includes patients with relapse of osteosarcoma in the lung following surgical resection of all gross disease (2nd or greater CR). Following comple... Read More
Gender:
ALL
Ages:
Between 8 years and 30 years
Trial Updated:
06/04/2025
Locations: Hackensack University Medical Center, Hackensack, New Jersey +1 locations
Conditions: Osteogenic Sarcoma Recurrent
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The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial
NCT05754632
Recruiting
While there are a number studies that have reported on the use of blood flow restriction training (BFRT) in the adult population, there is limited information about the use of BFRT in the adolescent population. This study aims to evaluate the use of BFRT in conjunction with traditional anterior ligament reconstruction (ACLR) rehabilitation in adolescents. The purpose of this study is to compare the addition of a BFRT based exercise protocol to a standard ACL rehabilitation protocol in adolescen... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
06/04/2025
Locations: Connecticut Children's Sports Physical Therapy, Farmington, Connecticut
Conditions: Anterior Cruciate Ligament Injuries, Knee Injuries, Quadriceps Muscle Atrophy
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A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma
NCT05757102
Recruiting
The primary purpose of this study is to evaluate the effects of Fluticasone Furoate (FF)/ Umeclidinium (UMEC)/ Vilanterol (VI) on lung function compared with FF/VI after 24 weeks of treatment.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
06/04/2025
Locations: GSK Investigational Site, Birmingham, Alabama +34 locations
Conditions: Asthma
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Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery
NCT05766891
Recruiting
To hypnosedation alone given before and during surgery on reducing opioid use after surgery compared to standard general anesthesia given alone or with hypnosedation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Breast Cancer
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Effects of Breathing and Attention Training (BAT) on Pain Modulation
NCT05773482
Recruiting
The hypersensitivity of fibromyalgia is associated with abnormal pain modulation within the CNS, but not with peripheral or central sensitization. Many brain areas that contribute to modulation of pain are known, but their testing is complex and expensive. Quantitative sensory testing is easier to perform and repeatable. Therefore, it will be used to evaluate the effects of Breathing Attention Training (BAT) on the hypersensitivity of FM participants. BAT is a form of mindfulness meditation show... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/04/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Fibromyalgia
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PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial
NCT05775939
Recruiting
This clinical trial examines positron emission tomography (PET)/computed tomography (CT) in evaluating cardiac radiation damage in patients with lung or esophageal cancer. As part of the treatment for lung or esophageal cancer, patients will undergo radiation therapy. Sometimes, during this treatment, the heart is also subjected to some radiation which could affect its function, either increasing or decreasing the function. It is not known the consequences of this change nor is it known if docto... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Lung Carcinoma, Esophageal Carcinoma
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A Study of NALIRIFOX in Combination With Radiation Therapy in People With Pancreatic Ductal Adenocarcinoma (PDAC)
NCT05851924
Recruiting
The researchers are doing this study to find out whether using the chemotherapy regimen NALIRIFOX in combination with ablative dose radiation therapy (AD-XRT) and the standard chemotherapy drug capecitabine is an effective treatment approach for people with locally advanced or borderline resectable pancreatic ductal adenocarcinoma (PDAC) before surgery. This type of treatment approach is called total neoadjuvant therapy (TNT). The researchers will also look at whether the sequence of the treatme... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Pancreatic Ductal Adenocarcinoma
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