A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
NCT06564038
Recruiting
The purpose of this study is to assess the safety and efficacy of AZD0486 administered as monotherapy or in combination with other anticancer agents in participants with hematological malignancies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Research Site, Boston, Massachusetts +49 locations
Conditions: Chronic Lymphocytic Leukaemia, Small Lymphocytic Leukaemia, Mantle-cell Lymphoma, Large B-cell Lymphoma, B-cell Non-Hodgkin Lymphoma
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A Study to Assess the Safety, Tolerability, and Pharmacokinetics of VH4011499 Compared to Placebo in Adults Without HIV
NCT06724640
Recruiting
The purpose of this study is to investigate safety and tolerability following single ascending subcutaneous (SC) and intramuscular (IM) doses of VH4011499 in participants without HIV. The study will also describe the pharmacokinetics following single ascending SC and IM doses of VH4011499 in participants without HIV.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
02/13/2025
Locations: GSK Investigational Site, Las Vegas, Nevada
Conditions: HIV Infections
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Phase I Trial of 5-Fluorouracil (5FU) -Based Therapy in Combination With Hydroxytyrosol (HT) in Patients With Advanced or Metastatic Colorectal Cancer
NCT06833866
Recruiting
This is a phase I study investigating the safety and antitumor activity of 5FU-based therapy (FOLFIRI/FOLFOX + Biologics) in combination with Hydroxytyrosol (HT) as a treatment for patients with advanced or metastatic colorectal cancer. Patients will receive: 1 capsule of HT 25 mg daily for 2 weeks before beginning 5FU-based therapy (FOLFIRI/FOLFOX + Biologics), 1 capsule of HT (25 mg) daily for 2 weeks while receiving the FOLFIRI/FOLFOX + Biologics, until sign of disease progression. The pres... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Houston Methodist., Houston, Texas
Conditions: Advanced or Metastatic CRC
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Periprosthetic Fracture Registry (PPFx)
NCT03378557
Recruiting
This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty. A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity and mortality, improved patient safety, improved quality of care and medical decision-making, reduced medical spending, and advances in orthopaedic science.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: University of Missouri Health Care, Columbia, Missouri +12 locations
Conditions: Periprosthetic Fractures, Periprosthetic Fracture Around Prosthetic Joint Implant
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Anterior Cervical Disectomy and Fusion Using the Tritanium® C Anterior Cervical Cage for One or Two-Levels
NCT04214535
Recruiting
This is a prospective, single arm clinical study to evaluate fusion status and patient reported outcomes utilizing the Stryker Tritanium® C Anterior Cervical interbody device at one or two contiguous levels. Subjects that are recommended for surgical treatment of either a 1- or 2-level ACDF (Anterior Cervical Discectomy and Fusion) between the levels of Cervical Spine 2 to Thoracic 1 (C2-T1) and diagnosed with degenerative disc disease will be screened for the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
Conditions: Cervical Disc Herniation, Cervical Disc Degeneration, Degenerative Disc Disease
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Using Re-inforcement Learning to Automatically Adapt a Remote Therapy Intervention (RTI) for Reducing Adolescent Violence Involvement
NCT04850274
Recruiting
This study will use a randomized control trial (RCT) design to administer two versions of a multisession remote behavioral intervention for youth seeking Emergency Department care for a violent injury with the goal to reduce their violence involvement and associated negative behaviors and consequences. The study examines two versions of the remote therapy intervention - a standard RTI (S-RTI) and an Artificial Intelligence RTI (AI-RTI). The application of a just-in-time adaptive strategy to addr... Read More
Gender:
ALL
Ages:
Between 14 years and 24 years
Trial Updated:
02/13/2025
Locations: Grady Health System, Atlanta, Georgia +3 locations
Conditions: Violence, Substance Use, Criminal Behavior, Violence in Adolescence
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Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
NCT05147909
Recruiting
Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/13/2025
Locations: University of Texas Southwestern, Dallas, Texas
Conditions: Physical Inactivity, Phosphate Overload, Visceral Obesity
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Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
NCT05365477
Recruiting
The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and empiric strategies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Kidney Stones, Nephrolithiasis
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Linezolid for Syphilis Pilot Study
NCT05548426
Recruiting
The study aims to evaluate the efficacy of linezolid for the treatment of syphilis.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
02/13/2025
Locations: Howard Brown Health, Chicago, Illinois +1 locations
Conditions: Syphilis
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Preliminary Testing of Cafe Move for Primary Prevention of Physical Frailty
NCT05720507
Recruiting
This project explores a novel means of health promotion and prevention of age-related physical frailty, which is designed to overcome barriers to access and promote autonomy in managing physical health.
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
02/13/2025
Locations: University of Montana, Missoula, Montana
Conditions: Aging
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Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer
NCT05950464
Recruiting
This phase Ib trial tests the safety, side effects, and best dose of M1774 when given with ZEN-3694 in treating patients with ovarian and endometrial cancer that has come back (recurrent). M1774 and ZEN-3694 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. M1774 and ZEN-3694 combined together has demonstrated to be better than either drug alone in killing ovarian tumor cells.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Augusta University Medical Center, Augusta, Georgia +12 locations
Conditions: Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Ovarian Clear Cell Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma, Platinum-Resistant Ovarian Carcinoma, Endometrial Low Grade Endometrioid Adenocarcinoma, Ovarian Low Grade Endometrioid Adenocarcinoma
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Sing for Your Saunter Part 2 R33
NCT06115382
Recruiting
The goal of this clinical trial is to compare to rhythm-based walking interventions to enhance gait in people with Parkinson's disease. The main questions it aims to answer are: * How does rhythm-based training influence walking performance? * How does brain activity change following rhythm-based training? Participants will perform walking to music and walking while singing, and will train on the use of these rhythms for 12 weeks. The investigators will compare the effects of training with musi... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
02/13/2025
Locations: Washington University School of Medicine, St. Louis, Missouri +1 locations
Conditions: Parkinson Disease
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