Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing
NCT05818189
Recruiting
The purpose of the study is to determine the effects of a novel, personalized, tactile cueing system on gait automaticity. The researchers hypothesized that step-synchronized tactile cueing will reduce prefrontal cortex activity (improve automaticity) and improve gait variability (as well as gait speed). The researchers predict that improved automaticity with improved gait variability will be associated with increased activation of other than prefrontal cortical areas while walking (i.e., sensor... Read More
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
05/23/2025
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Parkinson Disease
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Testing the Pain Clinical Practice Guideline
NCT05858996
Recruiting
There are evidence based processes for assessment and management of pain using pharmacologic and nonpharmacological approaches. These were reviewed and included within the Pain Management Clinical Practice Guideline (Pain Management CPG) recently developed by AMDA: The Society for Post-Acute and Long-Term Care Medicine. There are, however, many challenges to translating the use of Clinical Practice Guidelines into clinical settings. To overcome these challenges we developed and previously tested... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
05/23/2025
Locations: Future Care Coldspring, Baltimore, Maryland +6 locations
Conditions: Pain, Dementia
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Study of AVZO-021 in Patients With Advanced Solid Tumors
NCT05867251
Recruiting
This study, the first clinical trial of AVZO-021, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and anti-tumor effects of AVZO-021 in patients with advanced solid tumors. AVZO-021 is an oral medication that inhibits cyclin-dependent kinase 2 (CDK 2).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Yale Cancer Center, New Haven, Connecticut +9 locations
Conditions: Advanced Solid Tumor, HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer, CCNE1 Amplification, Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer, Endometrial Cancer, TNBC - Triple-Negative Breast Cancer
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Systems Science Approaches to Improve Access to Healthier Foods: The FRESH Trial
NCT05869149
Recruiting
Working with independently owned restaurants, a common source of calorie-rich, nutrient-poor foods in predominantly minority, low-income urban neighborhoods, has the potential to improve dietary quality, and contribute to cancer prevention. This study uses systems science approaches to improve access to healthier foods in independently owned restaurants by: 1) testing the effects of a novel intervention called FRESH (Focus on Restaurant Engagement to Strengthen Health) on dietary quality, health... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/23/2025
Locations: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Conditions: Healthy Eating Index
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SenseToKnow Autism Screening Device Validation Study
NCT05874466
Recruiting
This is a pivotal, prospective, double-blind, study to evaluate the sensitivity and specificity of the SenseToKnow app for the detection of autism spectrum disorder in children 16-36 months of age.
Gender:
ALL
Ages:
Between 16 months and 36 months
Trial Updated:
05/23/2025
Locations: Duke University, Durham, North Carolina
Conditions: Autism, Autism Spectrum Disorder
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Subpectoral Bupivacaine for Pain Management in Adolescent Reduction Mammaplasty
NCT05898087
Recruiting
The main question this randomized control trial aims to answer is: • Is the use of intraoperative subpectoral bupivacaine associated with decreased post-operative pain in adolescent patients who undergo bilateral reduction mammaplasty Participants will be randomized into the study group that intraoperatively receives 30cc of subpectoral bupivacaine injections or into the control group that intraoperatively receives 30cc of injectable saline subpectorally. All participants will keep a pain log... Read More
Gender:
ALL
Ages:
Between 13 years and 25 years
Trial Updated:
05/23/2025
Locations: Connecticut Children's, Farmington, Connecticut +1 locations
Conditions: Macromastia, Post-operative Pain
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LEADing Dementia End-of-Life Planning Conversations
NCT05909189
Recruiting
Advance care planning is important for all adults, but perhaps even more so for the 5.7 million persons with Alzheimer's disease or related dementia (ADRD), due to the progressive and protracted cognitive deterioration associated with the disease process. In the context of ADRD, medical decision-making at the end of life is typically left to one's care partner, who often does not have the knowledge or confidence in their ability to make such decisions. This study will refine and evaluate a web-b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: University of Utah College of Nursing, Salt Lake City, Utah
Conditions: Alzheimer Disease, Mild Cognitive Impairment
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Building TrUst and UNiting Teams Through DouLa partnErship - BUNDLE
NCT05993689
Recruiting
The BUNDLE study is a prospective mixed-methods study focused on the early integration of community doula into prenatal care. The study will have three phases: Phase 1 is the qualitative phase of conducting focus groups with Black/African American (AA) birthing people and with medical and community healthcare providers to elicit feedback on how best to integrate community-based doulas and obstetricians into one united model of prenatal care to promote trust and improved maternal health outcomes.... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
05/23/2025
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Pregnancy Related
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OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
NCT06016738
Recruiting
This phase 3 clinical trial compares the safety and efficacy of palazestrant (OP-1250) to the standard-of-care options of fulvestrant or an aromatase inhibitor in women and men with breast cancer whose disease has advanced on one endocrine therapy in combination with a CDK4/6 inhibitor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Clinical Trial Site, Tucson, Arizona +173 locations
Conditions: Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer, HER2 Negative Breast Carcinoma
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People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity
NCT06055868
Recruiting
This is an exploratory qualitative study among People Living With HIV (PLWH) of diverse racial/ethnic and sexual and gender minority (SGM) identities to explore individual, interpersonal, and structural oral health equity factors that serve as barriers or facilitators of accessing oral health care, knowledge and perceptions of human papillomavirus (HPV) vaccination and Oral squamous cell carcinoma (OSCC) /Oropharyngeal squamous cell carcinoma (OPSCC), and to collect recommendations on how to inc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: HIV Infections, Oral Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
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The Sequestration of Holistic Stress Management Techniques for Adults
NCT06098755
Recruiting
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life. In awareness of a support system, Bachelor's age 30 and older requirements were waived to accept the Bachelor's age 21-29 for verified relatives of an individual Humanitarian Veterans Association member; however, without BLOOD-QUANTUM to an individual Humanitarian Veterans Association member, the preferred Bachelor age is 30 years old... Read More
Gender:
MALE
Ages:
21 years and above
Trial Updated:
05/23/2025
Locations: Virtual Tribunal Monastery, Anchorage, Alaska
Conditions: Stress, Job
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Investigation of a 3 oz Water Protocol on Patients With Tracheostomies
NCT06120790
Recruiting
Examining the validity of a novel 3 oz protocol in patients with tracheostomies as compared to the gold standard of instrumental swallow assessments (Flexible Endoscopic Evaluation of the Swallow or Modified Barium Swallow Study).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Mount Sinai Hospital, New York, New York
Conditions: Tracheostomy
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