The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study
Recruiting
EFFEKTOR is a vanguard, multicenter, phase 2 randomized, double blinded, placebo controlled clinical trial to determine the feasibility, tolerability, safety, and efficacy of finerenone in kidney transplant recipients (KTRs). One hundred fifty (150) KTRs will be randomized in a 2:1 ratio of finerenone to placebo, with two embedded substudies: (i) a kidney biopsy substudy in 50 participants who undergo a research kidney biopsy prior to randomization and at the end of active treatment; and (ii) a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: UNC Eastowne Kidney Transplant Clinic, Chapel Hill, North Carolina
Conditions: Kidney Transplant; Complications
A Text- and Audio-based Intervention to Promote Physical Activity in Midlife
Recruiting
This is a randomized, controlled pilot trial (N=30) to examine the feasibility, acceptability, and preliminary efficacy of the Move with Meaning program, an 8- week, text message- and audio-based intervention to promote physical activity in midlife adults.
Gender:
ALL
Ages:
Between 45 years and 64 years
Trial Updated:
05/22/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Middle Aged
Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline
Recruiting
The investigators aim to conduct a randomized controlled trial to compare two symptom-management programs for Black older adults with early cognitive decline (self-reported confirmed by testing) and chronic pain. The programs are Mindfulness-Based Cognitive Therapy with Walking (MBCT+w) and Active Living Every Day (ALED). The investigators will assess how each program may help in improving physical, cognitive, and emotional function. The investigators will also assess whether improvements in out... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/22/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Chronic Pain, Physical Activity, Older Adults, Mild Cognitive Impairment
DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma
Recruiting
The purpose of this study is to determine if the investigational products, DB107-RRV and DB107-FC, as a combination treatment will shrink high-grade glioma (HGG) in patients with recurrent/progressive, resectable or unresectable disease and increase the time that disease is controlled.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/22/2025
Locations: University of Miami Hospital, Miami, Florida
Conditions: High Grade Glioma, Anaplastic Astrocytoma
Effects of SinuSonic on Psychological and Physical Well-Being
Recruiting
The goal of this clinical trial is to evaluate the effects of using the SinuSonic on psychological and physical well-being in adults who have nasal/sinus congestion. The study aims are: * Aim #1: to evaluate the effect of the SinuSonic on physical and psychological well-being in individuals with chronic nasal congestion; * Aim #2: to evaluate the relationship between autonomic reactivity and psychological well-being (i.e., anxiety and depression) in individuals with chronic nasal congestion; *... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/22/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Nasal Congestion and Inflammations, Sinus Congestion Chronic
MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels
Recruiting
This is a multicenter, randomized, single-blind pivotal study to evaluate the safety and efficacy of the MagicTouchTM Drug coated balloon in treatment of small vessels in patients with coronary artery disease. The objective is to establish the safety and efficacy of the Magic TouchTM Drug coated balloon in treatment of small vessels (≤2.75 mm). A total of 1605 subjects will be enrolled in a maximum of 50 study sites located in North America. Additional sites located in Europe and South America... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/22/2025
Locations: Dignity Health - Mercy Gilbert Medical Center, Gilbert, Arizona +25 locations
Conditions: Coronary Artery Disease, Native Coronary Artery Stenosis, Cardiovascular Diseases
Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway
Recruiting
This is a multicenter, Phase 1/2 clinical trial to evaluate DCC-3084 alone or in combination with other cancer therapies in participants with advanced cancers. Module A will enroll participants with advanced/metastatic solid tumors. Additional modules exploring other cancers may be added to the master protocol at a later date. Each module will be conducted in 2 parts: Part 1 (Dose Escalation) and Part 2 (Dose Expansion).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: University of Southern California - Norris Comprehensive Cancer Center, Los Angeles, California +8 locations
Conditions: Advanced Solid Tumor, RAF Mutation, RAS Mutation, NF1 Mutation, Non-Small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma, Melanoma, BRAF Gene Mutation, CRAF Gene Mutation, Castration-Resistant Prostate Cancer (CRPC)
Topical YR001 Ointment in Adult With Mild to Moderate Atopic Dermatitis
Recruiting
This study is to evaluate the safety, tolerability, and pharmacokinetics of YR001 topical ointment in adult patients with mild to moderate atopic dermatitis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Encore Medical Research -Boynton Beach, Boynton Beach, Florida +3 locations
Conditions: Atopic Dermatitis
SportsPro: Post-Market Clinical Follow Up Study
Recruiting
Retrospective, multi-center, chart review (only to include data that is part of the surgeons' standard practice)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Musculoskeletal-Orthopedic Research and Education Foundation, Phoenix, Arizona +2 locations
Conditions: Shoulder Injuries, Knee Injuries, Hip Injuries
An Open-label, Time-lagged, Dose-escalation Study to Evalaute the Safety and Efficacy of Subcutaneous Siplizumab in the Treatment of Hidradenitis Suppurativa.
Recruiting
This study is to investigate the efficacy of siplizumab in the treatment of Hidradenitis Suppurativa.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Hidradenitis Suppurativa
Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary Cholangitis
Recruiting
Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary Cholangitis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Zydus US007, Birmingham, Alabama +40 locations
Conditions: Primary Biliary Cholangitis
Eye Plaque Brachytherapy for Ocular Melanoma
Recruiting
This prospective registry study will evaluate doses utilized in eye plaque brachytherapy for the treatment of ocular melanoma and their associated outcomes. The goal of this study is to evaluate if lower doses of radiation can maintain high local control rates while minimizing the toxicities related to radiation therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Ocular Melanoma