Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy
NCT04888988
Recruiting
This phase II trial studies whether using exercise is better than the usual approach for treating chemotherapy-induced peripheral neuropathy (CIPN). CIPN occurs when chemotherapy damages the nerves communicating between the brain, spinal cord, and the rest of the body. The usual approach for treating CIPN is treatment with drugs that help reduce symptoms of other types of neuropathy (for example, from diabetes). However, these drugs do not treat all symptoms of CIPN. Exercise may help to reduce... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: Kaiser Permanente-Fresno, Fresno, California +92 locations
Conditions: Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
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A Phase 1/2 Study of Inlexisertib (DCC-3116) in Patients With RAS/MAPK Pathway Mutant Solid Tumors
NCT04892017
Recruiting
This is a Phase 1/2, multicenter, open label, first in human (FIH) study of inlexisertib as monotherapy, and in combination with trametinib, binimetinib, or sotorasib in patients with advanced or metastatic solid tumors with RAS/MAPK pathway mutation. The study consists of 2 parts, a dose-escalation phase, and an expansion phase.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts +9 locations
Conditions: Non-Small Cell Lung Cancer, Advanced Solid Tumor, Metastatic Solid Tumor
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Obeticholic Acid for Prevention in Barrett's Esophagus
NCT04939051
Recruiting
This phase II trial studies the effect of obeticholic acid in treating patients with Barrett's esophagus. Bile acids present in duodenogastroesophageal reflux contribute to neoplastic progression in Barrett's esophagus. Obeticholic acid has shown anti-cholestatic, anti-inflammatory and anti-fibrotic effects mediated by FXR activation. It down regulates bile acid availability and decreases proinflammatory cytokine production including IL-1beta and TNFalpha in human enterocytes and immune cells. T... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: University of Kansas Cancer Center, Kansas City, Kansas +7 locations
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma
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Zimberelimab (AB122) With TIGIT Inhibitor Domvanalimab (AB154) in PD-1 Relapsed/Refractory Melanoma
NCT05130177
Recruiting
The main goal of this study is to establish the proportion of patients with objective response to zimberelimab/domvanalimab in PD-1 R/R melanoma patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Melanoma
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Flexible Representation of Speech
NCT05209386
Recruiting
The overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratempo... Read More
Gender:
ALL
Ages:
Between 15 years and 25 years
Trial Updated:
05/02/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Epilepsy
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Robotic Gait Rehabilitation in Parkinson's Disease
NCT05218187
Recruiting
The purpose of this study is to investigate the implementation of a novel gait rehabilitation stimulus (G-EO System) that could advance current clinical practices. The goal is to establish the safety and feasibility of gait training using the G-EO System as well as investigating the impact on mobility, function, quality of life, and participatory outcomes. Research Design: We propose a single-blinded, randomized trial of electromechanically-assisted gait training using the G-EO System in patien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: IU Health Neurorehabilitation and Robotics, Indianapolis, Indiana
Conditions: Parkinson Disease, Gait Disorder, Sensorimotor
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Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
NCT05245500
Recruiting
This is a Phase 1, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: Mayo Clinic, Phoenix, Arizona +23 locations
Conditions: Mesothelioma, Non Small Cell Lung Cancer, Malignant Peripheral Nerve Sheath Tumors, Solid Tumor, Pancreatic Adenocarcinoma, Advanced Solid Tumor
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Anesthetic Optimization in Pediatric LeFort Surgeries
NCT05260320
Recruiting
This study will propose and evaluate a standardized LeFort osteotomy anesthetic protocol for pediatric patients at Johns Hopkins Hospital. There are two cohorts to this study: a prospective cohort who will receive the study anesthesia protocol and a historical cohort that received standard of care. The investigators hope this will help to minimize unnecessary postoperative pain management, inpatient stay, and long-term morbidity and mortality in these patients.
Gender:
ALL
Ages:
14 years and above
Trial Updated:
05/02/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Le Fort, Pain, Postoperative
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A Setting Focus Overdose Prevention Intervention
NCT05320835
Recruiting
A pilot injection-setting targeted peer-driven intervention to reduce HIV and hepatitis C virus transmission and overdose risk behaviors among people who inject drugs (PWID).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: Lighthouse Studies at Peer Point, Baltimore, Maryland
Conditions: HIV Infections, HCV, Drug Overdose
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THC Effects on Glucose in Type 2 Diabetes
NCT05322213
Recruiting
This study will examine the effects THC has on Glucose Metabolism and Endothelial Functioning in participants with Type 2 Diabetes. The participants will complete blood tests and tests to measure energy expenditure, CVD risks, and glucose metabolism. These tests will be performed prior to start of treatment and again after 2-weeks of treatment with the THC or placebo.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
05/02/2025
Locations: UC San Diego Altman Clinical & Translational Research Institute, La Jolla, California
Conditions: Type 2 Diabetes
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Home-Based Exercise Tele-Rehabilitation After COVID-19
NCT05425264
Recruiting
The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in catastrophic infections and fatalities across the nation. Many older Veterans with comorbidities are especially vulnerable to complications and poor recovery. This award will investigate the effect of a novel, home-based, supervised, group exercise tele-rehabilitation in Veterans recovered from COVID-19 on cardiopulmonary and physical function.
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
05/02/2025
Locations: Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland
Conditions: Post SARS-CoV2 (COVID-19)
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Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods
NCT05437809
Recruiting
The changing food environment, with increasingly abundant ultra-processed food (UPF) options, may directly contribute to rising rates of obesity, though it is unknown which ingredients in UPF elevate their reinforcing nature in a way that may lead to overconsumption. The proposed study is the first to systematically examine differences in the rewarding characteristics of and physiological and metabolic responses to UPFs that are high in fat, refined carbohydrates (like sugar), or both. Understan... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/02/2025
Locations: Drexel University, Philadelphia, Pennsylvania
Conditions: Obesity, Overeating, Food Addiction
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