Experimental Approach to Test Predictions of Body Weight Regulation Models
NCT06309576
Recruiting
The regulation of human body weight and fatness is not fully understood. Although some models of regulation have been proposed (set point, dual-intervention point, others), no studies have been designed to test their predictions. In this pilot and feasibility study, the investigators will implement an experimental approach to test the predictions of models of body weight regulation in humans. Men and women with either low body weight or obesity will be exposed to a 2-day fasting followed by a 2-... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/30/2025
Locations: Pennington Biomedical Research Center, Baton Rouge, Louisiana
Conditions: Obesity, Underweight
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Validation of the Screen of Cancer Survivorship - Occupational Therapy Services (SOCS-OTS) Tool for Use in a Physical Medicine Rehabilitation Clinic
NCT06329531
Recruiting
To compare the results of the SOCS-OTS to another standardized screening measure that is currently being used by rehabilitation services at MD Anderson Cancer Center and to ensure that the SOCS-OTS correctly identifies those individuals needing OT services in cancer care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Cancer, Occupational Therapy
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Packed Red Blood Cell Transfusion During Cardiac Arrest
NCT06462027
Recruiting
The purpose of this pilot interventional study is to collect preliminary data on administering packed red blood cell (PRBC) during cardiac arrest (CA). The primary objective is to assess the feasibility of PRBC transfusion during cardiac CA to help optimize the methods required to augment cerebral and other vital organ oxygen delivery during cardiopulmonary resuscitation (CPR). The secondary objectives are to assess the effect of PRBC transfusion during prolonged cardiac arrests on cerebral oxyg... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/30/2025
Locations: NYU Langone Health, New York, New York
Conditions: Cardiac Arrest
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AltaValve Pivotal Trial
NCT06465745
Recruiting
This is a prospective, single arm, multicenter, clinical trial designed to evaluate the safety and performance of the AltaValve System for the treatment of mitral regurgitation in a targeted patient population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Abrazo Arizona Heart Hospital, Phoenix, Arizona +28 locations
Conditions: Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
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A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia
NCT06525636
Recruiting
A first-in-human study of KK8123 in adults with X-linked hypophosphatemia.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/30/2025
Locations: University of California - San Francisco, San Francisco, California +7 locations
Conditions: X-linked Hypophosphatemia
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Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV
NCT06624839
Recruiting
This is a phase 2, open-label study to assess the immunogenicity of the 9-valent human papillomavirus (HPV) recombinant vaccine (Gardasil9) in people born male with current or past exposure to androgen blockers or estrogen (BM-EABE). Investigators will enroll BM-EABE with HIV and HIV negative controls (BM-EABE or men who have sex with a person with a penis (MSPP)) and administer Gardasil9 at timepoints Day 0, Month 2, and Month 6. The immune response to the vaccine will be analyzed at Month 7 (1... Read More
Gender:
MALE
Ages:
Between 18 years and 70 years
Trial Updated:
04/30/2025
Locations: RIIS Clinic at HIPS, Washington, District of Columbia +1 locations
Conditions: Human Papilloma Virus, Anal Dysplasia, HIV
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EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active
NCT06649058
Recruiting
To learn if consolidative stereotactic radiosurgery (cSRS) can help to control central nervous system (CNS) disease in patients who have brain metastases and have a partial response or stable brain metastases after systemic therapy. To learn if using SRS to treat all brain metastases that do not respond to systemic therapy versus treating only metastases that are getting worse can help to control CNS disease in patients whose disease gets worse after systemic therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: The University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Brain Metastases
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Convergent Mechanisms Underlying Reprometabolic Syndrome in Women
NCT06686537
Recruiting
Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.
Gender:
FEMALE
Ages:
Between 18 years and 38 years
Trial Updated:
04/30/2025
Locations: University of Colorado School of Medicine, Aurora, Colorado +1 locations
Conditions: Infertility, Female, Obesity
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A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 in Healthy Infants
NCT06720038
Recruiting
The objective of the study is to evaluate the safety, tolerability, and immunogenicity of 4 injections of VAX-31 (at 3 dose levels) compared to PCV20 in infants at 2, 4, 6, and 12-15 months of age, in addition to receiving routine US concomitant vaccines. Stage 1 of the study will comprise 3 dose ascending cohorts. Stage 2 of the study will enroll the remainder of the sample size.
Gender:
ALL
Ages:
Between 42 days and 89 days
Trial Updated:
04/30/2025
Locations: The Children's Clinic of Jonesboro, P.A, Jonesboro, Arkansas +47 locations
Conditions: Pneumococcal Vaccines
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A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease
NCT06753331
Recruiting
The Goal of this study is to evaluate the safety, tolerability, and clinical responses following implantation of DSP-1083. Study enrolls both male and female patients in 2 cohorts.This study will be held in approximately 5-6 study sites in North America
Gender:
ALL
Ages:
Between 40 years and 69 years
Trial Updated:
04/30/2025
Locations: University of Kentucky Medical Center, Lexington, Kentucky +1 locations
Conditions: Parkinson's Disease
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Family Foundations for Individuals Pregnant Via ART
NCT06770972
Recruiting
The purpose of this study is to help expectant single mothers build a coparenting bond and improve communication with a support person (co-caregiver). Participation will include completing two online surveys (one at 12-30 weeks gestation \& one at 3 months postpartum), providing two at-home bloodspot collections and return via mail. Studies suggest that stress increases inflammation. Investigators aim to explore this by collecting a small amount of blood at the first and last session; attending... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Assisted Reproductive Technology
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Project neuroARTEMIS
NCT06814275
Recruiting
The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this... Read More
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
04/30/2025
Locations: Wake Forest University School of Medicine, Winston-Salem, North Carolina
Conditions: Stimulant Use, Human Immunodeficiency Virus (HIV), Depression
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