Evaluation Of The Lung Microbiome In NTM Bronchiectasis
NCT02779478
Recruiting
A biomarker cohort study design is proposed to study whether specific airway microbiota alterations are associated with pulmonary Non-tuberculous mycobacteria (NTM) disease. In a cohort of 200 subjects suspected of having pulmonary NTM disease, the investigators will evaluate the airway microbiome using an aliquot of the induced sputum and upper airway samples. Since induced sputum may reflect different regions of the upper/lower airways, the investigators will evaluate the upper and lower airwa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: New York University School of Medicine, New York, New York
Conditions: Nontuberculous Mycobacteria, Bronchiectasis
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Post Approval Study of Lixelle for the Treament of Dialysis-Related Amyloidosis
NCT02952144
Recruiting
Dialysis-related amyloidosis (DRA) is a serious complication of long-term hemodialysis (HD). Its pathogenic mechanism involves accumulation of β2-microglobulin (β2M) in the blood. β2M is produced by most cells in the body and is metabolized in the kidney in healthy individuals. However, in HD patients with renal dysfunction, β2M which is not removed entirely by HD accumulates excessively in the blood. Then it forms amyloid fibrils that are deposited in bones, joints, and soft tissues. The fibril... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/29/2025
Locations: The Rogosin Institute, New York, New York
Conditions: Dialysis Amyloidosis
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Stereotactic Body Radiation Therapy or Intensity Modulated Radiation/Proton Therapy in Treating Patients With Recurrent Head and Neck Cancer
NCT03164460
Recruiting
This phase II trial studies how well stereotactic body radiation therapy or intensity modulated radiation/proton therapy works in treating patients with head and neck cancer that has come back. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Intensity modulated radiation/proton therapy uses high energ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Recurrent Head and Neck Carcinoma
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The Sleep Amyloid, Slow WAve Race and Ethnicity Study
NCT03814603
Recruiting
African-Americans (AAs) have an increased prevalence of both Alzheimer's disease (AD) and vascular risk factors for AD such as diabetes and hypertension when compared to whites. However, in a recent community based study of non-demented elderly, black race was associated with higher amyloid burden after adjusting for vascular risk factors, suggesting the presence of additional physiological differences on AD-risk by race in the early stages of the disease. The purpose of this study is to test wh... Read More
Gender:
ALL
Ages:
Between 60 years and 75 years
Trial Updated:
04/29/2025
Locations: NYU Center for Brain Health, New York, New York
Conditions: Alzheimer Disease
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PRISM Intervention Study
NCT03883139
Recruiting
This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as "minimally verbal" at age 6, by empirically developing a two-stage, 20-week adaptive intervention approach in a real world community settings. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status... Read More
Gender:
ALL
Ages:
Between 36 months and 59 months
Trial Updated:
04/29/2025
Locations: UCLA, Los Angeles, California +2 locations
Conditions: Autism Spectrum Disorder
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Functional Endoscopic Sinus Surgery Study
NCT03970655
Recruiting
The aim of this study is to evaluate the effect of the addition of epinephrine to bilateral real time ultrasound guided pterygopalatine ganglion blocks on intra-operative bleeding and blood loss during functional endoscopic sinus surgery (FESS).
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/29/2025
Locations: UF Health of University of Florida, Gainesville, Florida
Conditions: Chronic Rhinosinusitis (Diagnosis)
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Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer
NCT03971409
Recruiting
This phase II trial studies how well the combination of avelumab with liposomal doxorubicin with or without binimetinib, or the combination of avelumab with sacituzumab govitecan works in treating patients with triple negative breast cancer that is stage IV or is not able to be removed by surgery (unresectable) and has come back (recurrent). Immunotherapy with checkpoint inhibitors like avelumab require activation of the patient's immune system. This trial includes a two week induction or lead-... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: O'Neal Comprehensive Cancer Center, Birmingham, Alabama +11 locations
Conditions: Stage III Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer, Invasive Breast Carcinoma, Recurrent Breast Carcinoma, Triple-Negative Breast Carcinoma, Unresectable Breast Carcinoma
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Men Moving Forward: A Lifestyle Program for African-American Prostate Cancer Survivors
NCT03971591
Recruiting
This study will examine the efficacy of Men Moving Forward (MMF), a four-month community-based lifestyle intervention designed for AA PC survivors. MMF is rooted in the evidence-based Moving Forward lifestyle intervention developed with and for AA breast cancer survivors. This intervention was adapted in collaboration with AA PC survivors. It will offer twice weekly sessions aimed at supporting adherence to the ACS nutrition and physical activity guidelines to promote improved body composition (... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Prostate Cancer
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Web-Based Program in Helping Patients With Head and Neck Cancer Adhere to Swallowing Exercises and Coping Strategies
NCT04003051
Recruiting
This phase II trial studies how well a web-based program called Project Prepare works in helping patients with head and neck cancer adhere to swallowing and trismus exercises and coping strategies. Head and neck cancer patients who receive radiation therapy are at risk for permanent swallowing disorders and other side effects. Because of these potential problems, swallowing exercises and coping strategies are important parts of recovery. A web-based program designed to increase adherence to prev... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Texas Health Care-Otolaryngology and Plastic Surgery Associates, Fort Worth, Texas +1 locations
Conditions: Throat Carcinoma
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Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas
NCT04028063
Recruiting
This is an open-label, non-randomized, single-institution, single arm Phase II study conducted using a Simon two-stage design with an additional safety lead-in. The overall objective is to determine the efficacy of combination doxorubicin with dual checkpoint blockade with anti-CTLA-4 antibody AGEN1884 and anti-PD-1 antibody AGEN2034. The investigators will estimate the progression-free survival rate at 6 months (PFS6mo) of doxorubicin plus AGEN1884/AGEN2034 in comparison to historical PFS6mo wi... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/29/2025
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Metastatic Soft Tissue Sarcoma, Advanced Soft Tissue Sarcoma
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Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
NCT04061746
Recruiting
The goal of this study is to determine the safety and efficacy of fresh metabolically active allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) for the treatment of new-onset type 1 diabetes (T1D) and to understand the mechanisms of protection. If proven effective, such a strategy can be used as a therapeutic option for T1D patients and potentially other autoimmune disorders.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/29/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Diabetes Mellitus, Type 1
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MitraClip REPAIR MR Study
NCT04198870
Recruiting
The objective of this randomized controlled trial (RCT) is to compare the clinical outcome of MitraClip™ device versus surgical repair in patients with severe primary MR who are at moderate surgical risk and whose mitral valve has been determined to be suitable for correction by MV repair surgery by the cardiac surgeon on the local site heart team.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: University Hospital - Univiversity of Alabama at Birmingham, Birmingham, Alabama +84 locations
Conditions: Mitral Valve Regurgitation
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