CNGB1 and Allied Disorders
NCT04639635
Recruiting
Mutations in the rod-expressed gene, cyclic nucleotide-gated channel beta subunit (CNGB1) and associated inborn errors in metabolism are causes of retinal disease that causes progressive loss of vision. Retinitis pigmentosa (RP) is a major cause of untreatable blindness associated with CNGB1 (CNGB1-RP). RP involves the death of photoreceptor cells that can be caused by mutations in a number of different genes. Treatment by gene therapy could prevent blindness in cases of inherited retinal dystro... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/25/2025
Locations: Dr. Stephen H. Tsang, New York, New York +5 locations
Conditions: Retinitis Pigmentosa Associated With CNGB1 Mutations
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C-Brace Prospective Registry
NCT04640584
Recruiting
To gather prospective safety and effectiveness data for the C-Brace System following the standard of care.
Gender:
ALL
Ages:
All
Trial Updated:
04/25/2025
Locations: Jonesboro P&O x Ottobock.care, Harrison, Arkansas +75 locations
Conditions: Pareses, Lower Extremity
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Development of Patient Derived Xenografts (PDX) in Patients With Breast Cancer
NCT04703244
Recruiting
Breast cancer patients who undergo neoadjuvant systemic therapy and have residual breast cancer identified at the time of surgery exhibit a high (\>50%) risk of future life-threatening recurrences and death.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Breast Cancer, Residual
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Genetic Studies of Early-onset Dementia
NCT04906863
Recruiting
The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Dementia, Early Onset
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(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685
Recruiting
This is a randomized, double-blind, placebo-controlled, Phase 2/3 study comparing the efficacy and safety of elenestinib (BLU-263) + symptom directed therapy (SDT) with placebo + SDT in participants with indolent systemic mastocytosis (ISM) whose symptoms are not adequately controlled by SDT. Parts 1 and 2 will enroll participants with ISM. Participants enrolled in Part 2 will roll over onto Part 3 to receive treatment with elenestinib in an open-label fashion following completion of the earlier... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +52 locations
Conditions: Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis
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Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer
NCT04931017
Recruiting
This phase II trial determines the effect of metformin extended release on the risk for developing lung cancer in overweight/obese patients that are at high-risk for developing lung cancer. Metformin is widely used to treat type II diabetes and has a long history of safety and minimal side effects. At similar dosage, the drug may have potential anti-cancer activity. Metformin use has been associated with improved survival in patients with non-small cell lung carcinoma, a specific type of lung ca... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
04/25/2025
Locations: Rocky Mountain Regional VA Medical Center, Aurora, Colorado +3 locations
Conditions: Lung Carcinoma
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Intraamniotic Administrations of ER004 to Male Subjects With X-linked Hypohidrotic Ectodermal Dysplasia
NCT04980638
Recruiting
This is an open-label, prospective, genotype-match controlled for primary estimand, non randomized, multicenter, international Phase 2 clinical trial designed to investigate the efficacy and safety of ER004 administered intraamniotically as a treatment for unborn XLHED male subjects.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California +7 locations
Conditions: X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED)
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Medrol Dosepak for Outpatient Total Knee Arthroplasty
NCT05097976
Recruiting
The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA). We hypothesize that administration of an oral methylprednisolone taper starting on postoperative day 1 (POD 1) following TKA will be associated with improved pain and decreased opioid use, nausea, and complications at POD1-7, as compared to similar patients who receive pla... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: Rush Oak Brook Outpatient Center, Oak Brook, Illinois
Conditions: Total Knee Arthroplasty
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Risk and Benefits of Electronic Cigarettes to Older Smokers at High Risk for Lung Cancer
NCT05144542
Recruiting
This clinical trial investigates the effects of switching from smoking regular cigarettes to electronic cigarettes (e-cigarettes) among older adult smokers at high risk for lung cancer. E-cigarettes use heated vapor to deliver nicotine. Information gained from this trial may help inform regulators of the potential risks and benefits of switching smokers at high risk for lung cancer to electronic cigarettes. This research also may help inform the Food and Drug Administration (FDA) how best to reg... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
04/25/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Lung Carcinoma
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Food Prescriptions to Promote Affordable Diets
NCT05309395
Recruiting
This is an Randomized controlled trial (RCT) to assess the impact of meal planning and affordable grocery delivery on weight loss, dietary quality and health on members of multigenerational Latino households.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
04/25/2025
Locations: Kaiser Permanente, Pasadena, California
Conditions: Diet, Healthy, Overweight and Obesity
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Stereotactic Liver Ablation Assisted With Intra-Arterial CT Hepatic Arteriography and Ablation Confirmation Software Assessment (STEREOLAB)
NCT05361551
Recruiting
To achieve adequate tumor treatment coverage with sufficient minimal ablation margins, several steps are required: firstly, it is critical to define tumor boundaries and extent on intra-procedural CT image; secondly, accurate planning, targeting, and confirmation of ablation probe placement within the tumor; thirdly, the use of an intra-procedural imaging assessment method to evaluate minimal ablation margins is required to define whether sufficient minimal ablation margins was obtained or if ad... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Liver Ablation, Hepatic
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Lemborexant in Delayed Sleep Phase Syndrome
NCT05463861
Recruiting
The purpose of the study is to evaluate whether Lemborexant is more effective than placebo in shortening sleep onset latency in patients with delayed sleep phase syndrome (both type 1 and type 2). This will be tracked using sleep logs as well as actigraphy. In this 2-year study, we will examine if Lemborexant administered 5-10 mg nightly taken at desired bedtime (at least 2 hours prior to self-reported sleep onset habitual time) can improve the symptoms of Delayed Sleep Phase Syndrome.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: Stanford Univeristy, Redwood City, California
Conditions: Delayed Sleep Phase Syndrome
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