Reducing Pregnancy Risks: The Mastery Lifestyle Intervention
NCT05012072
Recruiting
This randomized controlled trial will test an intervention called the Mastery Lifestyle Intervention (the MLI) that was developed from data of 1000+pregnant Hispanic women related to risks of preterm birth. The investigators will deliver a psychoeducational intervention that is manualized over 6 group sessions. The investigators will also have a usual care group that receives standard prenatal care. The investigators plan to enroll 238 pregnant women and start the study with them at 14-20 weeks... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
01/15/2025
Locations: Anthony Chavez, MD, Houston, Texas
Conditions: Mental Health Wellness 1, Preterm Birth
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Network Connectivity and Temporal Processing in Adolescents Who Stutter
NCT05286151
Recruiting
The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).
Gender:
ALL
Ages:
Between 9 years and 13 years
Trial Updated:
01/15/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Stuttering, Childhood, Stuttering
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Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction
NCT05674786
Recruiting
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural instability and unsteady vision due to bilateral vestibular hypofunction. Prior research focused on ototoxic cases has demonstrated that electrical stimulation of the vestibular nerve via a chronically implanted multichannel vestibular implant can partially restore vestibular ref... Read More
Gender:
ALL
Ages:
Between 22 years and 90 years
Trial Updated:
01/15/2025
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD), Gentamicin Ototoxicity, Labyrinth Diseases, Vestibular Diseases, Sensation Disorders, Bilateral Vestibular Hypofunction, Bilateral Vestibulopathy, Aminoglycoside Ototoxicity
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Danvatirsen Monotherapy Followed by Combination With Venetoclax in Relapsed/Refractory MDS & AML
NCT05986240
Recruiting
This is a Phase 1 study investigating the safety and efficacy of Danvatirsen as a monotherapy followed by combination with Venetoclax in patients with relapsed/refractory myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). Funding Source: FDA OOPD
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: Montefiore Medical Center, Bronx, New York +1 locations
Conditions: AML/MDS, Acute Myeloid Leukemia, Myelodysplastic Syndromes
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Cooling Strategies for Older Adults in the Heat
NCT06349616
Recruiting
The earth's climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing. Humans sweat and increase blood flow to the skin to cool their body when they get hot. Older adults do not do this as well as young adults. This makes it harder to safely be in warm and/or humid conditions. It is important to learn about cooling strategies for older adults to safely be in warm and/or humid conditions. There is compelli... Read More
Gender:
ALL
Ages:
Between 65 years and 100 years
Trial Updated:
01/15/2025
Locations: Noll Laboratory, University Park, Pennsylvania
Conditions: Aging
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A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease
NCT06572384
Recruiting
Interstitial lung disease (ILD) is a lung condition resulting in inflammation and stiffening of the lung, often associated with connective tissue diseases (CTDs). ILD causes reduction in lung volume, shortness of breath, cough and fatigue therefore has high impact on quality of life and is also the leading cause of death in participants with these conditions. The study will assess whether treatment of CTD-ILD participants with belimumab in addition to standard therapy will result in the stabiliz... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: GSK Investigational Site, Naples, Florida +51 locations
Conditions: Lung Diseases, Interstitial
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The Use of Cyproheptadine in Pediatric Feeding Disorders
NCT06751290
Recruiting
The goal of this clinical trial is to learn if Cyproheptadine, an appetite stimulant, can improve eating habits in children with Pediatric Feeding Disorders. Pediatric Feeding Disorders is a broad term that describes disorders of eating-related behaviors that causes altered consumption of food and impairs physical or psychosocial health.
Gender:
ALL
Ages:
Between 2 years and 6 years
Trial Updated:
01/15/2025
Locations: University of Miami Department of Pediatric Gastroenterology, Miami, Florida
Conditions: Pediatric Feeding Disorder, Chronic, Avoidant Restrictive Food Intake Disorder
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Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study
NCT02740634
Recruiting
This is a neuroimaging study designed to learn more about amyloid and tau burden in the brain of patients with typical and atypical Alzheimer's Disease and how burden may change over a one year period.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
01/15/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Atypical Alzheimer's Disease, Logopenic Progressive Aphasia (LPA), Posterior Cortical Atrophy (PCA), Alzheimer Disease, Alzheimer Disease, Early Onset, Amnestic Disorder, Amnestic Symptoms, Amnestic Mild Cognitive Disorder
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Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
NCT04344769
Recruiting
The purpose of this study is to characterize oxidative stress and the Nrf2 antioxidant response in early stages of Autosomal Dominant Polycystic Kidney Disease (ADPKD), while identifying candidate biomarkers.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
01/15/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Autosomal Dominant Polycystic Kidney Disease
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Post-prostatectomy Radiation Therapy--Moderate Versus Ultra-hypofractionated (Also Known as Stereotactic Body Radiation Therapy [SBRT])
NCT05038332
Recruiting
The primary purpose of this study is to compare the quality of life (QOL) reported by prostate cancer patients 2 years after treatment with ultra-hypofractionated post-prostatectomy radiation therapy (also known as stereotactic body radiation therapy \[SBRT\]) versus the self-reported QOL of those treated with moderately hypo-fractionated post-prostatectomy radiation (a current standard of care option).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: University of Michigan Rogel Cancer Center, Ann Arbor, Michigan
Conditions: Prostate Cancer
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Intrarenal Microvasculature in ADPKD
NCT05288998
Recruiting
The primary objective of this study is to evaluate the use of Super-resolution ultrasound (SRU) to assess the intrarenal microvasculature in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and healthy volunteers.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
01/15/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Autosomal Dominant Polycystic Kidney Disease
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Long-term Follow-up After Adoptive Transfer of Genetically Modified Cell Products
NCT05713214
Recruiting
Human gene therapy products are designed to achieve therapeutic effect through genetic modifications of human cells using retroviral or lentiviral vectors, resulting in permanent or long-acting changes in the human body. With this genetic modification comes risk of undesirable adverse events. Due to this risk, the Food and Drug Administration (FDA) and the Center for Biologics Evaluation and research (CBER) require long-term follow-up (15 years) of participants that receive investigational gene... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/15/2025
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy
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