Contrast Enhanced Spectral Mammography for the Evaluation of Pathologic Nipple Discharge
Recruiting
This clinical trial studies contrast enhanced spectral mammography (CESM) for the evaluation of pathologic nipple discharge. CESM is similar to standard mammography, but it includes an intravenous (by vein) injection of an iodine-based contrast, which makes tissue and blood vessels more visible in scans. The goal of this trial is to learn if CESM, is better than standard mammography in quickly and efficiently determining the cause of nipple discharge and detecting breast cancer, if present. CESM... Read More
Gender:
FEMALE
Ages:
Between 25 years and 85 years
Trial Updated:
04/18/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Breast Carcinoma
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
Recruiting
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/18/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough
Recruiting
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with interstitial lung disease (ILD)-related cough.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/18/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Interstitial Lung Disease
Immune Responses to Gluten
Recruiting
This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.
Gender:
ALL
Ages:
Between 2 years and 101 years
Trial Updated:
04/18/2025
Locations: Children's Hospital Colorado, Aurora, Colorado +1 locations
Conditions: Celiac Disease, Malabsorption Syndromes, Digestive System Disease, Intestinal Disease, Gastrointestinal Diseases, Gluten Sensitivity, Celiac Disease in Children
Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine
Recruiting
The main purpose of this study is to investigate the effects of ketamine on decision-making and emotion processing in a sample of individuals diagnosed with Major Depressive Disorder (MDD).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/18/2025
Locations: Emory University, Atlanta, Georgia
Conditions: Major Depressive Disorder
Mosunetuzumab Consolidation Therapy After autoSCT in r/r Aggressive B Cell Lymphoma
Recruiting
This phase 1 pilot study examines the feasibility and safety of mosunetuzumab after autologous stem cell transplant for patients with aggressive B cell lymphomas. Mosunetuzumab is an antibody that has been engineered to attach to two target cells in the immune system: T cells that normally perform tasks like killing virus-infected cells, and cancerous B cells. Mosunetuzumab has been designed to direct these T cells to kill the cancerous B cells instead.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: B Cell Lymphoma, Aggressive Lymphoma, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Transformed Lymphoma, Follicular Lymphoma Grade 3
Vancomycin Study in Multiple Sclerosis (MS)
Recruiting
The overall goal of this study is to elucidate a mechanism by which vancomycin modulates the gut-brain axis in multiple sclerosis (MS). The gut microbiome plays an important role in autoimmunity, including MS. However, the identity of gut microbes modulating neuroinflammation in MS and their mechanisms of action remain obscure. Hence, here the research team proposes to investigate the effects of vancomycin on the gut microbiota composition, peripheral immune function, and brain MRI lesions in MS... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/18/2025
Locations: Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Sinai, New York, New York
Conditions: Multiple Sclerosis
Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder
Recruiting
A double-blind randomized placebo-controlled trial to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with posttraumatic stress disorder (PTSD) symptom improvement when prescribed for the treatment of chronic hepatitis C viral infection (HCV).
Gender:
ALL
Ages:
Between 19 years and 70 years
Trial Updated:
04/18/2025
Locations: White River Junction VAMC, White River Junction, Vermont
Conditions: Ptsd
Cardiac Rehabilitation of Stroke Survivors (SRP-CROSS)
Recruiting
This study examines the effectiveness of the cardiac rehabilitation program for stroke patients. The study will examine if patients with stroke, who receive cardiac rehabilitation in addition to their standard of care treatments, demonstrate improved recovery of function. It will also examine if these patients have reduced hospital readmission, reduced rate of recurrent stroke, and mortality.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2025
Locations: Hackensack Meridian Health - JFK Johnson Rehabilitation Institute, Edison, New Jersey
Conditions: Stroke, Cerebrovascular Accident
Post Operative Urinary Retention (POUR) Following Thoracic Oncological Surgery
Recruiting
This is a feasibility study looking at whether the use of Tamsulosin could lower the high incidence of postoperative urinary retention (POUR) in older men who undergo an oncological thoracic surgical procedure for suspected or confirmed cancer. In addition, the study will try to identify the time of resumption of presurgical urinary function post Tamsulosin administration.
Gender:
MALE
Ages:
55 years and above
Trial Updated:
04/18/2025
Locations: Ocean University Medical Center, Brick, New Jersey +3 locations
Conditions: Urinary Retention
With Love, Grandma ("Con Cariño, Abuelita") Pilot Study
Recruiting
The purpose of this study is to assess the feasibility, acceptability, and preliminary effects of a digital (web and mobile-phone-based) program to improve lifestyle behaviors (physical activity, dietary intake) among Hispanic female cancer survivors and adult daughters.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
04/18/2025
Locations: University of Miami, Miami, Florida
Conditions: Cancer, Breast, Cancer, Uterus, Cancer, Ovary, Obesity, Activity, Motor, Diet, Healthy
Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED
Recruiting
The primary objective of the study is to investigate the safety and efficacy of KPI-012 compared to vehicle in participants who have a documented clinical diagnosis of PCED.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2025
Locations: Principal Investigator, Dothan, Alabama +46 locations
Conditions: Persistent Corneal Epithelial Defect