DSLT Performance in Treatment-naïve Patients With Newly Diagnosed Open Angle Glaucoma
NCT06933836
Recruiting
DSLT demonstrates a ≥ 20% reduction of IOP from pre-treatment baseline in POAG patients naïve of previous glaucoma treatment at 12 months.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
04/16/2025
Locations: Barnet Dulaney Perkins Eye Centers, Mesa, Arizona
Conditions: Open Angle Glaucoma (OAG)
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Changing Youth Narratives on Firearm Violence ("Run It Up") Intervention
NCT06940362
Recruiting
The Run It Up project is an experimental, theory-driven effort to address a specific connection between structural factors, youth identity development, and violence, where structural factors in some communities may limit adolescent beliefs about potential life-trajectories ("possible selves"), and foreground potential trajectories that include violence as integral. The intervention seeks to counter that dynamic by: 1) identifying alternative, non-violent identity trajectories that have attribute... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
04/16/2025
Locations: George Washington University Milken Institute School of Public Health, Washington, District of Columbia
Conditions: Injury Prevention
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Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds
NCT06941467
Recruiting
Topical timolol, a β2-Adrenergic receptor (B2AR) antagonist, has demonstrated promise in wound healing over the past several years. The majority of the literature has evaluated the use of topical timolol to shorten wound healing time in chronic wounds of non-surgical etiologies. To date, there are no prospective randomized clinical trials evaluating the role of topical timolol for shortening wound healing time in acute open surgical wounds. Therefore, the purpose of this study is to determine w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2025
Locations: Mount Sinai, New York, New York
Conditions: Wound Healing, Mohs Micrographic Surgery
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Phase 2 Trial of RGX-314 in Adults With Center Involved - Diabetic Macular Edema (CI - DME)
NCT06942520
Recruiting
Phase 2 open label, randomized, active controlled, dose-ranging trial in adults with Center Involved - Diabetic Macular Edema (CI - DME)
Gender:
ALL
Ages:
Between 25 years and 89 years
Trial Updated:
04/16/2025
Locations: Sierra Eye Associates, Reno, Nevada
Conditions: Diabetic Macular Edema
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A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)
NCT06942572
Recruiting
This Phase 1/2 study will evaluate the safety, tolerability, and preliminary efficacy of subretinal SB-007 administration to determine dose selection in subjects with Stargardt's Type 1 (STGD1). This is a multicenter study which will enroll approximately 57 subjects, followed up over a 96 week period post treatment after a single administration of SB-007.
Gender:
ALL
Ages:
Between 12 years and 65 years
Trial Updated:
04/16/2025
Locations: UCHealth Sue Anschutz-Rodgers Eye Center,, Aurora, Colorado +4 locations
Conditions: Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy
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Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life
NCT00639301
Recruiting
The purpose of this study is to find out about the quality of life and health in a group of adults who had retinoblastoma when they were children. By quality of life, we mean how you are feeling about being satisfied with things in your life, including your physical health, your emotional health, and your ability to carry out daily activities. We hope that this information will help us provide better care to future children with retinoblastoma and better follow-up care for survivors of retinobla... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: Memorial Sloan Kettering Cancer Center, New York, New York
Conditions: Retinoblastoma
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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
NCT01351545
Recruiting
This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.
Gender:
ALL
Ages:
All
Trial Updated:
04/15/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +140 locations
Conditions: Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Severe Aplastic Anemia, Autoimmune Diseases
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Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease
NCT01665326
Recruiting
This is a longitudinal natural history study of Infantile Pompe disease. The investigators will regularly collect and review medical information regarding the diagnosis of Pompe disease, response to enzyme replacement (ERT) using alglucosidase alfa (Lumizyme/Myozyme) and response to immunosuppressive therapy in cases at risk for developing or those who have developed high and sustained antibodies to ERT. To follow the long-term outcomes, we will collect medical records including but not limited... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/15/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Pompe Disease
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Phase II Randomized Trial of Carboplatin+Pemetrexed+Bevacizumab+/- Atezolizumab in Stage IV NSCLC
NCT03786692
Recruiting
While cigarette smoking remains the primary cause of most lung cancer cases, lung carcinoma in never smokers account for nearly 20 percent of cases. Never smokers with lung cancer typically present with different molecular profiles from that of smokers, which results in prognostic and therapeutic implications. Molecular changes in NSCLC that have therapeutic significance include mutations in the epidermal growth factor receptor (EGFR) and rearrangements in the anaplastic lymphoma kinase (ALK) ge... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Non-Small Cell Carcinoma of Lung, TNM Stage 4
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Detection and Amelioration of Gamma Oscillation Abnormalities in Blast-Related Brain Injury
NCT03836976
Recruiting
Combat Veterans of post-9/11 conflicts have experienced serious cognitive and emotional problems resulting from exposure to blasts. Recent work suggests that a critical factor influencing the consequences of blast exposure is distance from the blast, rather than the presence or absence of concussion symptoms. Exposure to blasts from a distance of \<10 m has been associated with significantly greater cognitive and neural problems than exposure to blasts from \>10 m. So far, the effects of blast-r... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/15/2025
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: mTBI
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Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
NCT03919292
Recruiting
To determine the recommended phase 2 dose (RP2D) of the combination of neratinib and sodium valproate when given to patients with advanced solid tumors. Then to explore the antitumor effects of the neratinib and sodium valproate combination in advanced solid tumors with attention to RAS-mutated tumors, EGFR-altered GBM, and ocular melanoma, as part of the phase 2 expansion cohort.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia
Conditions: Solid Tumor, Adult
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Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation
NCT03995238
Recruiting
The population of older Veterans with non-traumatic lower limb amputation is growing. Following lower limb amputation, asymmetrical movements persist during walking and likely contribute to disabling sequelae including secondary pain conditions, poor gait efficiency, impaired physical function, and compromised skin integrity of the residual limb. This study seeks to address chronic gait asymmetry by evaluating the efficacy of two error-manipulation gait training programs to improve gait symmetry... Read More
Gender:
ALL
Ages:
Between 40 years and 89 years
Trial Updated:
04/15/2025
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado +1 locations
Conditions: Transtibial Amputation, Peripheral Artery Disease, Diabetes Mellitus
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