Transcranial Magnetic Stimulation for MCI
NCT05992831
Recruiting
The goal of this phase II study is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (accelerated Transcranial Magnetic Stimulation (TMS)) to improve both depression and cognitive function in Mild Cognitive Impairment (MCI) patients with comorbid depression. It is known that TMS can effectively treat depression. Identifying the right dose of accelerated TMS in MCI patients is necessary prior to designing subsequent trials to determin... Read More
Gender:
ALL
Ages:
Between 60 years and 85 years
Trial Updated:
04/14/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Mild Cognitive Impairment, Depression
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Descartes-08 for Patients With Systemic Lupus Erythematosus
NCT06038474
Recruiting
This is a Phase II study to evaluate the safety, tolerability and manufacturing feasibility of Descartes-08 CAR T-cells in patients with Systematic Lupus erythematosus (SLE).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Profound Research LLC, Oceanside, California
Conditions: Systemic Lupus Erythematosus (SLE)
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A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
NCT06056297
Recruiting
The purpose of this study is to demonstrate the efficacy and evaluate the safety and tolerability of mavorixafor in participants with congenital or acquired primary autoimmune and idiopathic chronic neutropenic disorders who are experiencing recurrent and/or serious infections as assessed by demonstrating its clinical benefit and increasing levels of circulating neutrophils.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
04/14/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +79 locations
Conditions: Neutropenia
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Improving the Mental Health of Home Health Aides
NCT06071221
Recruiting
The goal of this study is to improve the mental health of home health aides, a workforce that provides care for adults at home but whose own health has been historically poor. The main questions the study aims to answer are: * Will a health program called Living Healthy, which provides health education and support with positive thinking, be used by home health aides and do they like it? * Does Living Healthy actually improve home health aides' mood compared to what they usually do to take care... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: 1199 SEIU Home Care Industry Education Fund, New York, New York +1 locations
Conditions: Mental Health Issue
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Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers
NCT06085716
Recruiting
To find out if combining psychoeducational interventions (such as education, counseling, and self-managed therapies) with an open-label placebo can help to improve your quality of life better than either the psychoeducational interventions or the placebo alone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: MD Anderson Cancer Centerr, Houston, Texas
Conditions: Metastatic Cancers, Fatigue
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Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease
NCT06158620
Recruiting
Objective: To improve quality-of-life and health care delivery to patients receiving ureteral stents. Specific Aims: Evaluate the feasibility, practicality, and qualitative outcomes of utilizing intra-nasal ketorolac in patients with indwelling ureteral stents (Phase I), followed by a randomized trial comparing two non-steroidal anti-inflammatory drugs, intra-nasal Ketorolac versus oral Diclofenac. Hypotheses: Due to its favorable pharmacokinetics in relieving acute pain, investigators expect... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Post Operative Pain, Urolithiasis, Ureter Calculi, Stent Complication
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PRESERVE & CONNECT: Impact Study of the BPC
NCT06160050
Recruiting
The PRESERVE \& CONNECT project is a multi-site randomized control trial of the Breakthrough Parenting Curriculum: Navigating Trauma Across Generations (BPC) in rural and racially and ethnically diverse communities in Vermont and Connecticut.
Gender:
ALL
Ages:
All
Trial Updated:
04/14/2025
Locations: University of Connecticut, Hartford, Connecticut +1 locations
Conditions: Child Maltreatment, Trauma
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Menthol, Inflammation, and Nicotine Transition Study
NCT06232447
Recruiting
This study will focus on examining the potential impact of menthol flavoring in cigarettes on biomarkers of systemic inflammation as a subclinical indicator of cardiovascular disease risk.
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
04/14/2025
Locations: Rosalind Franklin University of Medicine and Science, North Chicago, Illinois
Conditions: Cigarette Smoking, Inflammatory Response
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A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors
NCT06253130
Recruiting
This study will evaluate the preliminary efficacy of IMP1734 in patients with recurrent advanced/metastatic breast cancer, ovarian cancer and metastatic castrate resistant prostate cancer (mCRPC) with deleterious/suspected deleterious mutations of select homologous recombination repair (HRR) genes.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
04/14/2025
Locations: University California Irvine, Irvine, California +23 locations
Conditions: Advanced Solid Tumor
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Understanding Patient Experience Among Asians at MD Anderson
NCT06259253
Recruiting
The purpose of this research study is to understand barriers to and facilitators of a positive patient experience for Asian patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Cancer
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Pramipexole to Enhance Social Connections
NCT06269146
Recruiting
This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression. The study plans to enroll 108 participants total across two sites (University of California San Diego and New York State Psychiatric Institute). Pramipexole will be given in a 6-week randomized, double-blind, placebo-controlled trial. Social reward processing will be assessed using measures of brain function (fMRI), behavior, and... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/14/2025
Locations: University of California, San Diego, San Diego, California +1 locations
Conditions: Anxiety Disorders, Anxiety, Depression, Social Disconnection
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High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial
NCT06298734
Recruiting
The purpose of this study is to determine whether high-intensity exercise and high-fiber diet are feasible and improve various health outcomes among participants with advanced melanoma receiving immunotherapy. The names of the groups in this research study are: * High-Intensity Exercise (EX) * High-fiber Diet (DT) * Combined High-Intensity Exercise and High-Fiber Diet (COMB) * Attention Control (AC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Melanoma (Skin), Skin Cancer, Advanced Melanoma
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