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ost-traumatic stress disorder (PTSD) is a mental health condition that can happen after experiencing a traumatic or terrifying event. Anybody, regardless of their age or gender can develop PTSD; however, experiencing a traumatic event doesn’t necessarily mean that a person will develop this disorder.

PTSD is different from the sense of discomfort or sadness that people feel when recalling negative experiences; individuals who suffer from PTSD tend to experience disturbing thoughts, trouble sleeping, and both mental and physical distress on a regular basis, particularly when triggered by internal or stimulus including sounds, smells, places or feelings.

A doctor or a mental health professional will diagnose a person with PTSD after he or she has experienced symptoms for at least a month after the traumatic event occurred. Because PTSD can affect anybody at any point in time, there are treatments available to help you deal with your symptoms and overcome trauma. Currently, the most effective treatments include a mix of psychotherapy and medication to help the person deal with the depression or anxiety that can happen alongside PTSD.

What Are Clinical Trials?

A clinical trial is a study conducted by medical professionals aiming to improve an existing treatment or find new alternatives for treating, preventing or diagnosing medical conditions. Many clinical trials begin at laboratories where research teams experiment with new drug ideas that could later become a treatment for a particular condition, then these medications are tested on volunteer human subjects to determine important factors such as it’s toxicity, side effects, and effectiveness.

Not all clinical trials involve testing new drugs or medications for treating a disease; some clinical trials rely merely on observation to determine how individuals respond or react to certain therapies or interventions. Other research studies might only want to collect blood or tissue samples to be later analyzed.

Regardless of the type of clinical trial, these studies are very rigorous and follow a predetermined set of rules and guidelines mandated by internal and external regulatory agencies. This means that clinical trials tend to be safe, and all participants are always closely monitored to ensure the trial runs smoothly and without any major inconveniences.

What Happens During A PTSD Clinical Trial?

Before you start participating in any type of clinical trial, a member of the research staff will make sure the entirety of the study has been explained to you, and they will ask you to sign an informed consent document.

An informed consent document is an official study document that explains the purpose of the study, any potential benefits and risks, and any other important information that you should know about before consenting to participate. It is important to note that even if you sign an informed consent document you are free to withdraw your participation from the trial at any point in time without consequence.

Because all clinical trials are different, what happens after giving consent will vary greatly depending on the type of study you enrolled into. Some mental health clinical trials involve medications; in these studies it is likely that the participant will be randomly assigned to a group to either receive a medication or a placebo. Researchers do this do determine the effectiveness of the medication whilst eliminating potential biases and confounders.

Will I Benefit From Participating In A Clinical Trial?

It is not possible to know whether a drug or a treatment being study in a clinical trial will be effective until it has gone through all phases and has been tested in many individuals. However, clinical trials are extremely important because they allow the medical field to move forward with the knowledge necessary to continue searching for cures, treatments, and preventive strategies for all kinds of conditions.

People participate in clinical trials for different reasons; some individuals with illnesses decide to participate in clinical trials for the opportunity of a potential new and effective treatment. Others choose to enroll in clinical trials to help science and medicine advance and helping others that might benefit from new drugs and treatments down the line.

Who Can Participate In A Clinical Trial?

Most clinical trials have an inclusion and exclusion criteria that outline who can and cannot participate based on the purpose of the study. While some trials want to have a very diverse sample and accept all kinds of volunteers, others might only look for individuals with a certain condition like PTSD or anxiety to test the medication or intervention on the specific population it is intended for.

Where Can I Find A PTSD Clinical Trial?

Clinical trials are often conducted by hospitals, universities or contract research organizations hired by pharmaceutical companies. If are thinking about enrolling in a PTSD clinical trial and would like to know what is available in your area, contact your doctor or mental health professional.

ClinicalTrials.gov: Recruiting Studies | Ptsd | Last update posted in the last 300 days Studies found on ClinicalTrials.gov by a search of: Recruiting Studies | Ptsd | Last update posted in the last 300 days

  • Neuroimmune System in PTSD
    on January 22, 2020 at 5:00 pm

    Condition:   Post Traumatic Stress DisorderIntervention:   Drug: LipopolysaccharideSponsor:   Yale UniversityRecruiting

  • Photobiomodulation to Improve Cognition in TBI, With fMRI
    on January 18, 2020 at 5:00 pm

    Conditions:   Traumatic Brain Injury;   Closed Head Injury;   Cognitive DysfunctionInterventions:   Device: Real LED Intervention;   Device: Sham LED InterventionSponsors:   Boston VA Research Institute, Inc.;   VA Boston Healthcare System;   Vielight Inc.Recruiting

  • Home-Delivered Attention Control Treatment for Post Traumatic Stress Disorder (PTSD)
    on January 14, 2020 at 5:00 pm

    Condition:   PTSDInterventions:   Behavioral: Attention Control Training (ACT);   Behavioral: Attention Bias Modification (ABM)Sponsor:   Tel Aviv UniversityRecruiting

  • Decreasing Suicide Risk Among Service Members With Posttraumatic Stress
    on January 13, 2020 at 5:00 pm

    Conditions:   Suicide;   Posttraumatic Stress DisorderInterventions:   Behavioral: Written Exposure Therapy -for Suicide;   Behavioral: Treatment as UsualSponsors:   Boston VA Research Institute, Inc.;   The University of Texas Health Science Center at San AntonioRecruiting

  • Post-traumatic Stress Injuries Among Paramedics and Emergency Dispatchers
    on December 17, 2019 at 5:00 pm

    Conditions:   Stress Disorders, Post-Traumatic;   Acute Stress Disorder;   Anxiety Disorders;   Depressive Disorder;   Substance Abuse;   AbsenteeismInterventions:   Other: Psychological first aid;   Other: Usual organisational interventionSponsor:   Centre de Recherche de l'Institut Universitaire en santé Mentale de MontréalRecruiting

  • Use of CBD Oil in the Treatment of Posttraumatic Stress Disorder
    on December 12, 2019 at 5:00 pm

    Condition:   Post Traumatic Stress DisorderInterventions:   Drug: Cannabidiol (CBD) oil;   Behavioral: Trauma focused group cognitive-behavioral therapy (CBT);   Other: Placebo oilSponsor:   University of Texas at AustinRecruiting

  • Tetris to Reduce Intrusive Memories in Parents After PICU
    on December 5, 2019 at 5:00 pm

    Condition:   Post-traumatic Stress DisordersIntervention:   Other: Behavioral: Simple cognitive taskSponsors:   King's College London;   Guy's and St Thomas' NHS Foundation TrustRecruiting

  • Perinatal Mental Health Care in Switzerland
    on December 4, 2019 at 5:00 pm

    Conditions:   Mental Disorder;   Perinatal;   Depression;   Anxiety Disorders;   Panic Disorder;   Post Traumatic Stress Disorder;   Adaptation Reaction;   Behavior Disorders;   Substance Abuse;   Psychosis;   Health Care Seeking Behavior;   Health Care Utilization;   Health Care AcceptabilityIntervention:   Sponsors:   Bern University of Applied Sciences;   University of BernRecruiting

  • Simple Cognitive Task After Trauma EKUT RCT
    on December 4, 2019 at 5:00 pm

    Condition:   Post Traumatic Stress DisorderInterventions:   Behavioral: Simple cognitive task;   Behavioral: Attention placeboSponsor:   Karolinska InstitutetRecruiting

  • Predicting SSRI Efficacy in Veterans With PTSD
    on December 3, 2019 at 5:00 pm

    Condition:   Posttraumatic Stress DisorderInterventions:   Diagnostic Test: LDAEP;   Drug: Placebo;   Drug: sertralineSponsors:   VA Office of Research and Development;   Middlebury College;   Suffolk University;   Massachusetts General HospitalRecruiting

  • An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample
    on November 29, 2019 at 5:00 pm

    Condition:   Stress Disorders, Post-TraumaticInterventions:   Diagnostic Test: CAPS-5;   Diagnostic Test: PSSI-5;   Diagnostic Test: CAPS-IVSponsor:   U.S. Army Medical Research and Development CommandRecruiting

  • Brexpiprazole as Combination Therapy With Sertraline in the Treatment of Adults With Post-traumatic Stress Disorder
    on November 22, 2019 at 5:00 pm

    Condition:   Post Traumatic Stress DisorderInterventions:   Drug: Brexpiprazole;   Drug: Sertraline;   Other: PlaceboSponsor:   Otsuka Pharmaceutical Development & Commercialization, Inc.Recruiting

  • ICU Diaries and Its Effects After the Unit Discharge
    on November 14, 2019 at 5:00 pm

    Conditions:   Post Intensive Care Unit Syndrome;   Intensive Care Unit Syndrome;   PTSD;   Anxiety Symptoms;   Depressive SymptomsIntervention:   Device: ICU DiariesSponsor:   Hospital Ernesto DornellesRecruiting

  • Effect of tDCS Timing on Safety Memory in PTSD
    on November 5, 2019 at 5:00 pm

    Condition:   PTSDIntervention:   Device: transcranial direct current stimulationSponsors:   Butler Hospital;   National Institute of General Medical Sciences (NIGMS)Recruiting

  • A Phase 3 Trial of Brexpiprazole as Combination Therapy With Sertraline in Treatment of Adults With PTSD
    on October 11, 2019 at 4:00 pm

    Condition:   Post Traumatic Stress DisorderInterventions:   Drug: Brexpiprazole;   Drug: Sertraline;   Other: PlaceboSponsor:   Otsuka Pharmaceutical Development & Commercialization, Inc.Recruiting

  • Wildlife and Wellbeing: An Animal-Assisted Intervention for Veterans With PTSD
    on October 4, 2019 at 4:00 pm

    Condition:   Stress Disorders, Post-TraumaticInterventions:   Other: Forest walk;   Other: Wildlife rehabilitation;   Other: Wildlife sanctuary observation;   Other: Bird feeding and watchingSponsors:   University of Massachusetts, Worcester;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Recruiting

  • Exercise and Therapeutic Learning Among Women With PTSD
    on October 3, 2019 at 4:00 pm

    Condition:   PTSDInterventions:   Other: Day 1 Assessments;   Other: Day 2 Fear Learning;   Other: Day 3 Fear Extinction;   Behavioral: Moderate Intensity Exercise;   Behavioral: Low Intensity Exercise;   Other: Day 4 Recall of Fear ExtinctionSponsor:   University of Wisconsin, MadisonRecruiting

  • An Internet-delivered Cognitive-behavioral Intervention Provided Soon After Trauma: a RCT
    on September 24, 2019 at 4:00 pm

    Condition:   Post Traumatic Stress DisorderIntervention:   Behavioral: Internet-based CBTSponsor:   Karolinska InstitutetRecruiting

  • PTSD Coach Sweden: Evaluating a Self-help Mobile App for Posttraumatic Stress in a Community Sample
    on September 19, 2019 at 4:00 pm

    Condition:   Posttraumatic StressIntervention:   Behavioral: Swedish PTSD Coach smartphone appSponsor:   Uppsala UniversityRecruiting

  • Ketone Supplementation in Individuals With PTSD
    on September 10, 2019 at 4:00 pm

    Conditions:   PTSD;   KetosisInterventions:   Dietary Supplement: Pruvit Ketomax Ketone Salt;   Dietary Supplement: PlaceboSponsor:   Augusta UniversityRecruiting

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