What is Sleep?
Although everyone needs to sleep to maintain their health, the question “what is sleep?” has proven surprisingly difficult. During the state of sleep, the brain exhibits profound changes.
It is now believed the function of sleep is to clear metabolic waste products from the pathways of the brain. This helps explain why healthy sleep must be sufficient in both duration and depth.

What Conditions Are Associated With Sleep?
The most common health condition associated with sleep is insomnia. Insomnia is difficulty falling asleep, staying asleep, or both. Sleep disturbances can be physiological in nature (for example, Restless Legs Syndrome) or psychological (for example, nightmares.)
Experts have estimated that about 25% of Americans develop some degree of insomnia in any given year. In 75% of cases, it passes without long-term damage to sleep habits.
Other common sleep disorders include:
- Snoring
- Sleep apnea, “pauses” in breathing often caused by soft tissue blockage in the airway
- Sleep hypoventilation, trouble breathing in sleep caused by respiratory muscle weakness
- Restless Legs Syndrome, which causes discomfort only alleviated by moving the legs
- Bruxism, the grinding of the teeth during sleep, which can damage the teeth and jaw
Sleep medicine experts also recognize several less common sleep disorders. These include things like narcolepsy, nightmares and night terrors, and Rapid Eye Movement Behavior Disorder.
Maintaining Sleep Health
Many chronic sleep conditions arise with no known cause. However, maintaining good sleep hygiene can help. Sleep hygiene refers to the whole collection of habits that affect sleep health.
In general, it is a good idea to develop a consistent bedtime and routine for “going to bed.” Discontinue the use of phones and other “screens” an hour before bed, since the blue light of these devices inhibits the brain’s natural response to reduced lighting at night.
Remember, many factors can contribute to sleep health issues:
- Certain medications, such as those used for high blood pressure and asthma
- Chronic pain disorders and other conditions that cause persistent discomfort
- Stress in your personal or work life and conditions like anxiety or depression
Each individual has a slight variance in sleep need. Likewise, the duration of sleep needed does change depending on life stage. However, it is important to know everyone needs about eight hours of nightly sleep to maintain mental and physical health.
Medical Research on Sleep
With the answers to key questions on “why do we sleep?” coming into view, sleep researchers are continuing to pursue clinical sleep studies looking for new sleep disorder treatments.
Sleep clinical care has undergone revolutionary changes in recent years thanks to imaging technology that precisely pinpoints sleep-related changes in the human brain at any age.
Current Clinical Trials on Sleep
This list includes all clinical trials on sleep recognized by ClinicalTrials.gov. To add sleep clinical trials to our list, contact us.
- Implementation & Dissemination of a Digital Health Intervention for Adolescent Sleepon June 3, 2025 at 4:00 am
Conditions: Insomnia; Adolescent; Digital Health Interventions: Behavioral: Firefly Mobile App: A Digital Health Solution for Healthy Sleep in Teens Sponsors: University of Kansas Medical Center Recruiting
- NE3107 in Adults With Neurological Symptoms of Long COVIDon June 3, 2025 at 4:00 am
Conditions: Long COVID Interventions: Drug: NE3107; Drug: Placebo Sponsors: BioVie Inc. Recruiting
- Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlandson June 3, 2025 at 4:00 am
Conditions: Parkinson Disease; Prodromal Stage; Neurodegenerative Diseases; Parkinsonian Disorders; REM Sleep Behavior Disorder; Basal Ganglia Diseases; Central Nervous System Diseases; Synucleinopathies; Nervous System Diseases; Cerebral Disorder; Brain Diseases Interventions: Behavioral: Increase of physical activity volume and intensity with the use of a motivational smartphone application Sponsors: Radboud University Medical Center; Stichting ParkinsonNL; ZonMw: The Netherlands Organisation for Health Research and Development; Michael J. Fox Foundation for Parkinson's Research; Parkinson's UK; Cure Parkinson's; Edmond J. Safra Foundation; Davis Phinney Foundation; Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen; Anne Wojcicki Foundation; Sleep Medicine Centre Kempenhaeghe; Sleep Medicine Centre SEIN; Queen Mary University of London; 23andMe, Inc.; Parkinsons Progression Markers Initiative (PPMI); Massachusetts General Hospital; Harvard School of Public Health (HSPH); IJsfontein B.V., Netherlands; Hoffmann-La Roche; Erasmus Medical Center; University of Illinois at Chicago; University of Rochester; University of Bristol; University of Plymouth; University of Luebeck; McGill University; University of Pittsburgh Recruiting
- UrbanHEAT: Health Behaviors, Outcomes, and Disparities in Individually Experienced Temperature Across an Urban Communityon June 3, 2025 at 4:00 am
Conditions: Temperature Sponsors: National Institute on Minority Health and Health Disparities (NIMHD); National Institute of Nursing Research (NINR) Recruiting
- Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorderson June 3, 2025 at 4:00 am
Conditions: Neurological Disorder; Autism; Sleep Sponsors: National Institute of Mental Health (NIMH) Recruiting
- Improving Night Shift Nurses' Health and Reducing Burnouton June 2, 2025 at 4:00 am
Conditions: Healthy Interventions: Behavioral: Access to napping/relaxation room; Other: Blue and green light blocking glasses Sponsors: University of Pittsburgh; Shadyside Hospital Foundation Recruiting
- Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apneaon May 31, 2025 at 4:00 am
Conditions: Sleep Apnea Interventions: Drug: Sivopixant; Drug: Placebo; Drug: Acetazolamide; Drug: SASS-001 Sponsors: Shionogi Apnimed Sleep Science Recruiting
- A Causal Role for Voltage-gated Cav1.2 Calcium Channels in Mediating 5G FR1 Effects on Sleep-associated Brain Health in Humanson May 31, 2025 at 4:00 am
Conditions: Mediation of 5G Effects on Sleep Interventions: Drug: Nimodipine Capsules; Radiation: 5G RF-EMF Sponsors: Hans-Peter Landolt; Federal Office for the Environment, Switzerland Recruiting
- Preoperative Sleep Intervention on Postoperative Delirium in School-aged Children Undergoing Congenital Heart Surgeryon May 31, 2025 at 4:00 am
Conditions: Delirium - Postoperative; Sleep Problems; Congenital Heart Disease (CHD) Interventions: Behavioral: cognitive-behavioral intervention Sponsors: Yan Fuxia Recruiting
- A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1on May 31, 2025 at 4:00 am
Conditions: Narcolepsy Interventions: Drug: JZP441; Drug: Matching Placebo Sponsors: Jazz Pharmaceuticals; Jazz Pharmaceuticals Ireland Limited Recruiting
- A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomniaon May 31, 2025 at 4:00 am
Conditions: Idiopathic Hypersomnia Interventions: Drug: ALKS 2680; Drug: Placebo Sponsors: Alkermes, Inc. Recruiting
- Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimulion May 31, 2025 at 4:00 am
Conditions: Normal Physiology Sponsors: National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
Why Are More Clinical Trials on Sleep Necessary?
There may be no single “cure for insomnia”, but clinical trials on sleep help doctors develop effective sleep disorder treatment protocols for the various situations where sleep is disturbed.
Ongoing sleep research continues to redefine what we know about each of these conditions. Insomnia treatments are just one of the new sleep clinical resources coming from this effort.
Conclusion
The majority of American adults experience sleep disturbances at some point in life. With that in mind, clinical trials on sleep truly affect everyone. Unfortunately, sleep disorders are under-diagnosed – and those who suffer often do not pursue treatment. Participating in clinical studies on sleep is one way to help ensure you, and others, will rest better.
Content Box
- https://www.sciencedaily.com/releases/2018/06/180605154114.htm
- https://www.sleephealthfoundation.org.au/pdfs/Insomnia.pdf
- https://www.hopkinsmedicine.org/health/wellness-and-prevention/the-future-of-sleep-studies
- https://www.sleepfoundation.org/insomnia/what-insomnia
- https://medlineplus.gov/sleepdisorders.html
- https://www.sleepfoundation.org/articles/sleep-hygiene