What is Sleep?
Although everyone needs to sleep to maintain their health, the question “what is sleep?” has proven surprisingly difficult. During the state of sleep, the brain exhibits profound changes.
It is now believed the function of sleep is to clear metabolic waste products from the pathways of the brain. This helps explain why healthy sleep must be sufficient in both duration and depth.

What Conditions Are Associated With Sleep?
The most common health condition associated with sleep is insomnia. Insomnia is difficulty falling asleep, staying asleep, or both. Sleep disturbances can be physiological in nature (for example, Restless Legs Syndrome) or psychological (for example, nightmares.)
Experts have estimated that about 25% of Americans develop some degree of insomnia in any given year. In 75% of cases, it passes without long-term damage to sleep habits.
Other common sleep disorders include:
- Snoring
- Sleep apnea, “pauses” in breathing often caused by soft tissue blockage in the airway
- Sleep hypoventilation, trouble breathing in sleep caused by respiratory muscle weakness
- Restless Legs Syndrome, which causes discomfort only alleviated by moving the legs
- Bruxism, the grinding of the teeth during sleep, which can damage the teeth and jaw
Sleep medicine experts also recognize several less common sleep disorders. These include things like narcolepsy, nightmares and night terrors, and Rapid Eye Movement Behavior Disorder.
Maintaining Sleep Health
Many chronic sleep conditions arise with no known cause. However, maintaining good sleep hygiene can help. Sleep hygiene refers to the whole collection of habits that affect sleep health.
In general, it is a good idea to develop a consistent bedtime and routine for “going to bed.” Discontinue the use of phones and other “screens” an hour before bed, since the blue light of these devices inhibits the brain’s natural response to reduced lighting at night.
Remember, many factors can contribute to sleep health issues:
- Certain medications, such as those used for high blood pressure and asthma
- Chronic pain disorders and other conditions that cause persistent discomfort
- Stress in your personal or work life and conditions like anxiety or depression
Each individual has a slight variance in sleep need. Likewise, the duration of sleep needed does change depending on life stage. However, it is important to know everyone needs about eight hours of nightly sleep to maintain mental and physical health.
Medical Research on Sleep
With the answers to key questions on “why do we sleep?” coming into view, sleep researchers are continuing to pursue clinical sleep studies looking for new sleep disorder treatments.
Sleep clinical care has undergone revolutionary changes in recent years thanks to imaging technology that precisely pinpoints sleep-related changes in the human brain at any age.
Current Clinical Trials on Sleep
This list includes all clinical trials on sleep recognized by ClinicalTrials.gov. To add sleep clinical trials to our list, contact us.
- The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Studyon June 22, 2025 at 4:00 am
Conditions: Obstructive Sleep Apnea; Cognitive Decline Interventions: Device: Positive airway pressure; Device: Oral appliance therapy; Device: Positional therapy Sponsors: California Pacific Medical Center Research Institute; Icahn School of Medicine at Mount Sinai; New York University; University of Arizona; University of Pittsburgh; National Institute on Aging (NIA) Recruiting
- MARPE-Associated Changes in Sleep and Airwayon June 22, 2025 at 4:00 am
Conditions: MARPE Interventions: Device: MARPE Sponsors: Konya Necmettin Erbakan Üniversitesi Recruiting
- Cascading A Healthy Sleep Intervention In Vocational Educationon June 22, 2025 at 4:00 am
Conditions: Sleep Quality; Implementation Interventions: Other: Healthy Sleep Intervention; Other: Co-creation process; Other: Training for teachers Sponsors: University Ghent Recruiting
- UrbanHEAT: Health Behaviors, Outcomes, and Disparities in Individually Experienced Temperature Across an Urban Communityon June 22, 2025 at 4:00 am
Conditions: Temperature Sponsors: National Institute on Minority Health and Health Disparities (NIMHD); National Institute of Nursing Research (NINR) Recruiting
- Investigation of the Effects of Pilates Training in Patients With Drug-Resistant Epilepsyon June 22, 2025 at 4:00 am
Conditions: Epilepsy; Cognitive Dysfunction; Seizures; Quality of Life; Sleep; Depression Interventions: Other: Pilates Group; Other: Control Group Sponsors: Recep Tayyip Erdogan University Training and Research Hospital Recruiting
- Pilot Study of App-delivered Sleep Coaching Among Cancer Survivors and Their Partnerson June 19, 2025 at 4:00 am
Conditions: Cancer Interventions: Behavioral: Sleep coaching; Behavioral: Sleep education Sponsors: University of Arizona Recruiting
- Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apneaon June 19, 2025 at 4:00 am
Conditions: Sleep Apnea Interventions: Drug: Sivopixant; Drug: Placebo; Drug: Acetazolamide; Drug: SASS-001 Sponsors: Shionogi Apnimed Sleep Science Recruiting
- OPTImizing CArdiac REhabilitation by REfining Sleep and STresson June 19, 2025 at 4:00 am
Conditions: Cardiovascular Diseases; Cardiac Rehabilitation Interventions: Behavioral: RESST Sponsors: Erasmus Medical Center; Capri Hartrevalidatie; Maxima Medical Center; ZonMw: The Netherlands Organisation for Health Research and Development Recruiting
- NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorderon June 19, 2025 at 4:00 am
Conditions: Bipolar Disorder; Major Depression; Migraine Sponsors: National Institute of Mental Health (NIMH) Recruiting
- Sleep for Stroke Management and Recovery Trialon June 19, 2025 at 4:00 am
Conditions: Ischemic Stroke; Sleep Apnea; Sleep Apnea, Obstructive; Stroke; CPAP; Telemedicine; Home Sleep Apnea Test; Randomized Clinical Trial; Multicenter Trial Interventions: Device: CPAP Sponsors: University of Michigan; National Institute of Neurological Disorders and Stroke (NINDS); FusionHealth LLC; Medical University of South Carolina; University of Cincinnati Recruiting
- A Study to Evaluate the Efficacy and Safety of Daridorexant in Participants With Insomnia Disorderon June 19, 2025 at 4:00 am
Conditions: Insomnia Disorder Interventions: Drug: Daridorexant; Drug: Placebo Sponsors: Nxera Pharma Korea Co., Ltd. Recruiting
- Effects of Foot Reflexology Massage in Migraineon June 19, 2025 at 4:00 am
Conditions: Migraine Disease Interventions: Other: Reflexology Massage Sponsors: Karabuk University Recruiting
Why Are More Clinical Trials on Sleep Necessary?
There may be no single “cure for insomnia”, but clinical trials on sleep help doctors develop effective sleep disorder treatment protocols for the various situations where sleep is disturbed.
Ongoing sleep research continues to redefine what we know about each of these conditions. Insomnia treatments are just one of the new sleep clinical resources coming from this effort.
Conclusion
The majority of American adults experience sleep disturbances at some point in life. With that in mind, clinical trials on sleep truly affect everyone. Unfortunately, sleep disorders are under-diagnosed – and those who suffer often do not pursue treatment. Participating in clinical studies on sleep is one way to help ensure you, and others, will rest better.
Content Box
- https://www.sciencedaily.com/releases/2018/06/180605154114.htm
- https://www.sleephealthfoundation.org.au/pdfs/Insomnia.pdf
- https://www.hopkinsmedicine.org/health/wellness-and-prevention/the-future-of-sleep-studies
- https://www.sleepfoundation.org/insomnia/what-insomnia
- https://medlineplus.gov/sleepdisorders.html
- https://www.sleepfoundation.org/articles/sleep-hygiene