What is Alcohol?
The alcohol in an alcoholic drink is ethanol, produced by fermenting grains, fruits, or other foods that contain sugar. Alcohol has been used as a beverage since prehistoric times. It is mentioned in ancient Egypt, Babylon, and many other societies.
Alcohol produces intoxication due to its chemical composition. Because alcohol molecules are so small, they easily disrupt the brain’s neurotransmitters. The body cannot store alcohol, so it is broken down by the liver and excreted in urine.

What Conditions is Alcohol Associated With?
Many people consume alcohol during recreational activities. Consumed infrequently, it may have few or no health effects. However, it is also associated with an extremely wide variety of dire health conditions, many of which are chronic and/or can be fatal.
About 15 million Americans suffer from an alcohol abuse disorder.
What’s more, only about 6.7% of people who have a drinking problem seek professional help. About 88,000 people die of alcohol-related causes every year. Problem drinking can result in physical dependence on alcohol.
Since alcohol consumption leads to reductions in reaction time, judgment, and decision-making, any episode of drinking can lead to harmful accidents or injury. However, most health risks of alcohol come from problem drinking, including binge drinking.
Conditions associated with long-term alcohol misuse include:
- High blood pressure, stroke, heart attack, and other cardiovascular events
- Cirrhosis (permanent scarring) of the liver caused by alcohol exposure
- A higher risk of certain cancers, including breast, mouth, throat, and liver
- Decline in cognitive performance, especially in learning and memory
- Greater likelihood of mental health complications like anxiety and depression
What Research Currently Exists on the Effects of Alcohol?
For many years, research around alcohol focused on the idea that it had health benefits if used in moderation. However, recent research is casting doubt on these long-held assumptions.
Over the last five years, scientific studies have confirmed the connection between even moderate alcohol use and premature death, cancer, stroke, and high blood pressure. Some studies also suggest that abstaining from alcohol can improve mental health.
In general, a scientific consensus is forming around the idea that zero alcohol consumption is the best approach for individuals who want to safeguard their overall health.
Why Are Further Clinical Trials on the Effects of Alcohol Important?
Alcohol and its risks have been researched extensively. However, there are still many areas where more findings are needed. 40%-60% of people treated for alcoholism eventually relapse. The precise brain chemistry involved in alcoholism and successfully abstaining from problem drinking are not understood. Quality of support for sufferers can be spotty.
A limited number of medications are available to help people with alcoholism. However, these are effective in only a fraction of cases.

Likewise, further research is necessary to support the anecdotal conclusions of treatment organizations, especially faith-based organizations, about the best way to provide social support during long-term treatment.
Current Clinical Trials on the Effects of Alcohol
This is the most recent list of clinical trials on the effects of alcohol submitted to ClinicalTrials.gov.
Alcohol clinical resources are developed by organizations worldwide. Watch this space for further information about alcohol studies that may lead to groundbreaking treatment. If you have a study to include on our site, contact our team.
- Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)on August 21, 2025 at 4:00 am
Conditions: Alcohol Use Disorder Interventions: Drug: Intravenous Ethanol; Drug: 18F-PF-06445974 Sponsors: National Institute of Mental Health (NIMH) Recruiting
- Environment and Alcohol: A Pilot Studyon August 21, 2025 at 4:00 am
Conditions: Alcohol Use Disorder Interventions: Behavioral: Evaluate the effects of Environmental Enrichment (EE) on alcohol consumption Sponsors: National Institute on Drug Abuse (NIDA) Recruiting
- Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorderon August 21, 2025 at 4:00 am
Conditions: Alcohol Use Disorder Interventions: Drug: Acamprosate calcium; Other: Placebo Sponsors: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- SMART-r: Substance Monitoring and Active Relapse Tracking Repositoryon August 21, 2025 at 4:00 am
Conditions: Alcoholism; Substance-Related Disorders Sponsors: National Institute on Drug Abuse (NIDA) Recruiting
- Comparison of the Effectiveness of Two Psycho-physical Interventions: Mindfulness Based Relapse Prevention (MBRP) and Unguided Meditative Relaxation in Patients With Alcohol Use Disorderon August 21, 2025 at 4:00 am
Conditions: Alcohol Use Disorder (AUD) Interventions: Behavioral: Mindfulness Based Relapse Prevention; Behavioral: Relaxation/ meditation Sponsors: Centre Hospitalier Universitaire de Nīmes Recruiting
- Adaptive Actions and Alcohol Use Outcomes During Internet-delivered Cognitive Behaviour Therapyon August 21, 2025 at 4:00 am
Conditions: Alcohol Misuse Interventions: Behavioral: Alcohol Change Course Enhanced Sponsors: University of Regina; Karolinska Institutet; Macquarie University, Australia; York University Recruiting
- Optimizing a Digital AEP Risk Intervention With Native Women and Communitieson August 19, 2025 at 4:00 am
Conditions: Alcohol Exposed Pregnancy; Unplanned Pregnancy; Alcohol Use, Unspecified; Contraception Use; Sexual Behavior Interventions: Behavioral: CARRII Native Rapid Pilot Testing Sponsors: University of Virginia; University of Minnesota; Missouri Breaks Industries Research, Inc.; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- Alpha-1 Blockade for Alcohol Use Disorder (AUD)on August 18, 2025 at 4:00 am
Conditions: Alcohol Use Disorder (AUD) Interventions: Drug: Doxazosin; Drug: Placebo Sponsors: Brown University Recruiting
- Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxson August 17, 2025 at 4:00 am
Conditions: Alcohol Use Disorder Interventions: Behavioral: Brief Motivational Interviewing; Behavioral: Culturally adaptation brief motivational interviewing Sponsors: University of Texas, El Paso; University of Texas at Austin; National Institute on Alcohol Abuse and Alcoholism (NIAAA); El Paso County General Hospital dba University Medical Center Recruiting
- Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisonson August 15, 2025 at 4:00 am
Conditions: PTSD - Post Traumatic Stress Disorder; PTSD and Alcohol Use Disorder; PTSD and Trauma-related Symptoms; Substance Use Disorder (SUD); Depression; Mental Health; Trauma; Trauma Exposure; Traumatic Stress Disorder; Traumatic Stress; Post Traumatic Stress Symptoms Interventions: Behavioral: Group Cognitive Processing Therapy (CPT); Behavioral: Control Group Individual trauma focused self-help via workbook Sponsors: University of Arkansas; National Institute on Drug Abuse (NIDA) Recruiting
- Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Designon August 15, 2025 at 4:00 am
Conditions: Alcohol Drinking; Alcohol Use Disorder (AUD); Alcohol Intoxication; Alcohol; Harmful Use; Alcoholism; Binge Drinking Interventions: Drug: Alcohol beverage; Other: Control - non alcoholic beverage Sponsors: University of Illinois at Urbana-Champaign Recruiting
- Characterization Imaging Instruments in Alcoholics and Non-Alcoholicson August 14, 2025 at 4:00 am
Conditions: Alcohol Dependence; Alcohol Drinking; Alcohol-Related Disorders; Alcoholism; Brain Mapping Sponsors: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
Conclusion
Alcohol has been part of human history for thousands of years. However, modern medicine still has a long way to go in managing the serious health risks associated with it. More alcohol clinical studies are crucial for discovering the alcohol clinical resources millions of people need to stop drinking.
Content Box
- https://www.drugfreeworld.org/drugfacts/alcohol.html
- https://www.alcoholproblemsandsolutions.org/history-of-alcohol-and-drinking-around-world/
- http://www.drinkingandyou.com/site/us/xdrunk.htm
- http://www.bbc.co.uk/newsbeat/article/30350860/the-science-of-alcohol-how-booze-affects-your-body
- https://www.verywellmind.com/prevalence-of-alcoholism-in-the-united-states-67876
- https://www.cdc.gov/alcohol/fact-sheets/alcohol-use.htm