What is Alcohol?
The alcohol in an alcoholic drink is ethanol, produced by fermenting grains, fruits, or other foods that contain sugar. Alcohol has been used as a beverage since prehistoric times. It is mentioned in ancient Egypt, Babylon, and many other societies.
Alcohol produces intoxication due to its chemical composition. Because alcohol molecules are so small, they easily disrupt the brain’s neurotransmitters. The body cannot store alcohol, so it is broken down by the liver and excreted in urine.

What Conditions is Alcohol Associated With?
Many people consume alcohol during recreational activities. Consumed infrequently, it may have few or no health effects. However, it is also associated with an extremely wide variety of dire health conditions, many of which are chronic and/or can be fatal.
About 15 million Americans suffer from an alcohol abuse disorder.
What’s more, only about 6.7% of people who have a drinking problem seek professional help. About 88,000 people die of alcohol-related causes every year. Problem drinking can result in physical dependence on alcohol.
Since alcohol consumption leads to reductions in reaction time, judgment, and decision-making, any episode of drinking can lead to harmful accidents or injury. However, most health risks of alcohol come from problem drinking, including binge drinking.
Conditions associated with long-term alcohol misuse include:
- High blood pressure, stroke, heart attack, and other cardiovascular events
- Cirrhosis (permanent scarring) of the liver caused by alcohol exposure
- A higher risk of certain cancers, including breast, mouth, throat, and liver
- Decline in cognitive performance, especially in learning and memory
- Greater likelihood of mental health complications like anxiety and depression
What Research Currently Exists on the Effects of Alcohol?
For many years, research around alcohol focused on the idea that it had health benefits if used in moderation. However, recent research is casting doubt on these long-held assumptions.
Over the last five years, scientific studies have confirmed the connection between even moderate alcohol use and premature death, cancer, stroke, and high blood pressure. Some studies also suggest that abstaining from alcohol can improve mental health.
In general, a scientific consensus is forming around the idea that zero alcohol consumption is the best approach for individuals who want to safeguard their overall health.
Why Are Further Clinical Trials on the Effects of Alcohol Important?
Alcohol and its risks have been researched extensively. However, there are still many areas where more findings are needed. 40%-60% of people treated for alcoholism eventually relapse. The precise brain chemistry involved in alcoholism and successfully abstaining from problem drinking are not understood. Quality of support for sufferers can be spotty.
A limited number of medications are available to help people with alcoholism. However, these are effective in only a fraction of cases.

Likewise, further research is necessary to support the anecdotal conclusions of treatment organizations, especially faith-based organizations, about the best way to provide social support during long-term treatment.
Current Clinical Trials on the Effects of Alcohol
This is the most recent list of clinical trials on the effects of alcohol submitted to ClinicalTrials.gov.
Alcohol clinical resources are developed by organizations worldwide. Watch this space for further information about alcohol studies that may lead to groundbreaking treatment. If you have a study to include on our site, contact our team.
- SMART-r: Substance Monitoring and Active Relapse Tracking Repositoryon April 2, 2025 at 4:00 am
Conditions: Alcoholism; Substance-Related Disorders Sponsors: National Institute on Drug Abuse (NIDA) Recruiting
- Alcohol Feedback, Reflection and Morning Evaluationon April 2, 2025 at 4:00 am
Conditions: Youth Drinking; Alcohol Drinking Interventions: Behavioral: Mobile-delivered personalized feedback Sponsors: Brown University; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- Approach-Avoidance and Alcohol Challenge Study in PTSDon April 2, 2025 at 4:00 am
Conditions: Post-Traumatic Stress Disorder; Alcohol Drinking Interventions: Other: Alcohol; Other: Placebo Sponsors: University of Texas at Austin Recruiting
- Text Messaging to Reduce High-risk Alcohol Use Among Older Adultson April 2, 2025 at 4:00 am
Conditions: Hazardous Alcohol Use Interventions: Behavioral: Text messaging Sponsors: University of Southern Denmark; Anette Søgaard Nielsen, PhD; Kjeld Andersen, PhD; Angelina Mellentin, PhD; Alexis Kuerbis Recruiting
- Environment and Alcohol: A Pilot Studyon April 2, 2025 at 4:00 am
Conditions: Alcohol Use Disorder Interventions: Behavioral: Evaluate the effects of Environmental Enrichment (EE) on alcohol consumption Sponsors: National Institute on Drug Abuse (NIDA) Recruiting
- Optimizing a Digital AEP Risk Intervention With Native Women and Communitieson April 2, 2025 at 4:00 am
Conditions: Alcohol Exposed Pregnancy; Unplanned Pregnancy; Alcohol Use, Unspecified; Contraception Use; Sexual Behavior Interventions: Behavioral: Survey Sponsors: University of Virginia; University of Minnesota; Missouri Breaks Industries Research, Inc.; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSDon April 1, 2025 at 4:00 am
Conditions: Post Traumatic Stress Disorder; Alcohol Use Disorder Interventions: Drug: Topiramate; Other: Placebo Sponsors: NYU Langone Health; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposureon April 1, 2025 at 4:00 am
Conditions: Fetal Alcohol Spectrum Disorders; Fetal Alcohol Syndrome Interventions: Dietary Supplement: Choline bitartrate; Dietary Supplement: Placebo Sponsors: Wayne State University; University of Cape Town; Columbia University Recruiting
- Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorderon April 1, 2025 at 4:00 am
Conditions: Alcohol Use Disorder Interventions: Other: Detoxification Program; Radiation: PKAB; Radiation: CFN Sponsors: Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- RTMS in Older Adults with MCI and AUDon March 30, 2025 at 4:00 am
Conditions: Alcohol Use Disorder; Mild Cognitive Impairment; Transcranial Magnetic Stimulation Interventions: Device: Active, Open Label iTBS-rTMS Sponsors: Medical University of South Carolina; National Institutes of Health (NIH); National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviorson March 30, 2025 at 4:00 am
Conditions: Alcohol Use Disorder Interventions: Other: Alcohol beverage; Other: Placebo beverage Sponsors: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- Behavioral Economic and Wellness-based Approaches for Reducing Alcohol Use and Consequences Among Emerging Adultson March 30, 2025 at 4:00 am
Conditions: Alcohol Abuse Interventions: Behavioral: Brief Alcohol Intervention (BAI); Behavioral: Substance-free Activity Session (SFAS); Behavioral: Relaxation Training (RT); Other: Education Control Sponsors: University of Memphis Recruiting
Conclusion
Alcohol has been part of human history for thousands of years. However, modern medicine still has a long way to go in managing the serious health risks associated with it. More alcohol clinical studies are crucial for discovering the alcohol clinical resources millions of people need to stop drinking.
Content Box
- https://www.drugfreeworld.org/drugfacts/alcohol.html
- https://www.alcoholproblemsandsolutions.org/history-of-alcohol-and-drinking-around-world/
- http://www.drinkingandyou.com/site/us/xdrunk.htm
- http://www.bbc.co.uk/newsbeat/article/30350860/the-science-of-alcohol-how-booze-affects-your-body
- https://www.verywellmind.com/prevalence-of-alcoholism-in-the-united-states-67876
- https://www.cdc.gov/alcohol/fact-sheets/alcohol-use.htm