2024 Alcohol Guide to Clinical Trials, Research & Treatment

What is it? Conditions Research Further Clinical Trials Conclusion

What is Alcohol?

The alcohol in an alcoholic drink is ethanol, produced by fermenting grains, fruits, or other foods that contain sugar. Alcohol has been used as a beverage since prehistoric times. It is mentioned in ancient Egypt, Babylon, and many other societies.

Alcohol produces intoxication due to its chemical composition. Because alcohol molecules are so small, they easily disrupt the brain’s neurotransmitters. The body cannot store alcohol, so it is broken down by the liver and excreted in urine.

What Conditions is Alcohol Associated With?

Many people consume alcohol during recreational activities. Consumed infrequently, it may have few or no health effects. However, it is also associated with an extremely wide variety of dire health conditions, many of which are chronic and/or can be fatal.

About 15 million Americans suffer from an alcohol abuse disorder.

What’s more, only about 6.7% of people who have a drinking problem seek professional help. About 88,000 people die of alcohol-related causes every year. Problem drinking can result in physical dependence on alcohol.

Since alcohol consumption leads to reductions in reaction time, judgment, and decision-making, any episode of drinking can lead to harmful accidents or injury. However, most health risks of alcohol come from problem drinking, including binge drinking.

Conditions associated with long-term alcohol misuse include:

High blood pressure, stroke, heart attack, and other cardiovascular events
Cirrhosis (permanent scarring) of the liver caused by alcohol exposure
A higher risk of certain cancers, including breast, mouth, throat, and liver
Decline in cognitive performance, especially in learning and memory
Greater likelihood of mental health complications like anxiety and depression

What Research Currently Exists on the Effects of Alcohol?

For many years, research around alcohol focused on the idea that it had health benefits if used in moderation. However, recent research is casting doubt on these long-held assumptions.

Over the last five years, scientific studies have confirmed the connection between even moderate alcohol use and premature death, cancer, stroke, and high blood pressure. Some studies also suggest that abstaining from alcohol can improve mental health.

In general, a scientific consensus is forming around the idea that zero alcohol consumption is the best approach for individuals who want to safeguard their overall health.

Why Are Further Clinical Trials on the Effects of Alcohol Important?

Alcohol and its risks have been researched extensively. However, there are still many areas where more findings are needed. 40%-60% of people treated for alcoholism eventually relapse. The precise brain chemistry involved in alcoholism and successfully abstaining from problem drinking are not understood. Quality of support for sufferers can be spotty.

A limited number of medications are available to help people with alcoholism. However, these are effective in only a fraction of cases.

Likewise, further research is necessary to support the anecdotal conclusions of treatment organizations, especially faith-based organizations, about the best way to provide social support during long-term treatment.

Current Clinical Trials on the Effects of Alcohol

This is the most recent list of clinical trials on the effects of alcohol submitted to ClinicalTrials.gov.

Alcohol clinical resources are developed by organizations worldwide. Watch this space for further information about alcohol studies that may lead to groundbreaking treatment. If you have a study to include on our site, contact our team.

Role of Pavlovian Mechanisms for Control Over Substance Use
on November 22, 2024 at 5:00 am
Conditions: Alcohol Use Disorder (AUD); Alcoholism; Substance Use Disorders; Cannabis Use Disorder; Methamphetamine-dependence; Amphetamine Use Disorder; Cocaine Use Disorder Interventions: Biological: fMRI imaging (BOLD); Biological: sMRI (structure); Behavioral: Pavlovian-to-instrumental transfer (PIT) paradigm; Diagnostic Test: Basic psychological assessment (interview); Diagnostic Test: Basic psychological assessment (questionnaires); Behavioral: Neuropsychological tests Sponsors: Technische Universität Dresden; Charite University, Berlin, Germany; Central Institute of Mental Health, Mannheim Recruiting
Assessing Habitual, Goal-Directed, and Pavlovian Influences in Alcohol Use Disorder
on November 22, 2024 at 5:00 am
Conditions: Alcohol Use Disorder (AUD); Alcoholism; Substance Use Disorders Interventions: Behavioral: Pavlovian-to-instrumental transfer (PIT) paradigm; Behavioral: Action Sequence Task (AST); Diagnostic Test: Basic psychological assessment (interview); Diagnostic Test: Basic psychological assessment (questionnaires); Behavioral: Neuropsychology tests Sponsors: Technische Universität Dresden; Charite University, Berlin, Germany; Central Institute of Mental Health, Mannheim Recruiting
Semaglutide Therapy for Alcohol Reduction (STAR)
on November 21, 2024 at 5:00 am
Conditions: Addiction; Alcohol Use Disorder Interventions: Behavioral: Take Control; Drug: Semaglutide Sponsors: National Institute on Drug Abuse (NIDA) Recruiting
CBT Vs. Supportive Texts for PTSD & Hazardous Drinking (Project Better Study 2)
on November 21, 2024 at 5:00 am
Conditions: Alcohol Use; Posttraumatic Stress Disorder Interventions: Behavioral: CBT Text Messages; Behavioral: Supportive Messages Sponsors: University of Washington; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
Effectiveness of Brief Intervention in Primary Care for Diverse Young People (Chat)
on November 21, 2024 at 5:00 am
Conditions: Adolescent Drinking; Cannabis Use Interventions: Behavioral: Chat; Behavioral: Enhanced Usual Care Sponsors: RAND; AltaMed Health Services Corporation; University of Pittsburgh Medical Center; Patient-Centered Outcomes Research Institute Recruiting
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
on November 21, 2024 at 5:00 am
Conditions: Alcohol Use Disorder (AUD); Healthy Volunteers Interventions: Drug: Suvorexant; Drug: Placebo Sponsors: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
Mindfulness for Alcohol Abusing Offenders
on November 20, 2024 at 5:00 am
Conditions: Alcohol Abuse; Criminal Behavior Interventions: Behavioral: Mindfulness; Behavioral: Relapse Prevention Sponsors: The Mind Research Network; University of Wisconsin, Madison Recruiting
Reducing Alcohol Involved Sexual Violence in Higher Education
on November 20, 2024 at 5:00 am
Conditions: Sexual Violence; Drinking Heavy Interventions: Behavioral: GIFTSS Training; Behavioral: Learning Collaborative; Behavioral: Provider Scripts Sponsors: University of Pittsburgh; Johns Hopkins University; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors
on November 19, 2024 at 5:00 am
Conditions: Alcohol Use Disorder Interventions: Other: Alcohol beverage; Other: Placebo beverage Sponsors: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
Combining a Smartphone App With Medications to Manage Heavy Drinking
on November 19, 2024 at 5:00 am
Conditions: Alcohol Use Disorder (AUD) Interventions: Other: Stand Down mobile app; Other: Standard Care Sponsors: VA Office of Research and Development Recruiting
Choline Supplementation As a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Study
on November 19, 2024 at 5:00 am
Conditions: Fetal Alcohol Spectrum Disorders Interventions: Drug: Choline Bitartrate Sponsors: Jeff Wozniak; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
Couples Health CoOp Plus
on November 19, 2024 at 5:00 am
Conditions: HIV; Substance Use; Stigma, Social Interventions: Behavioral: Community Stigma Awareness and Education Workshop; Behavioral: Couples Health CoOp Plus (CHC+) Sponsors: RTI International; Medical Research Council, South Africa Recruiting

Conclusion

Alcohol has been part of human history for thousands of years. However, modern medicine still has a long way to go in managing the serious health risks associated with it. More alcohol clinical studies are crucial for discovering the alcohol clinical resources millions of people need to stop drinking.