What is Alcohol?
The alcohol in an alcoholic drink is ethanol, produced by fermenting grains, fruits, or other foods that contain sugar. Alcohol has been used as a beverage since prehistoric times. It is mentioned in ancient Egypt, Babylon, and many other societies.
Alcohol produces intoxication due to its chemical composition. Because alcohol molecules are so small, they easily disrupt the brain’s neurotransmitters. The body cannot store alcohol, so it is broken down by the liver and excreted in urine.

What Conditions is Alcohol Associated With?
Many people consume alcohol during recreational activities. Consumed infrequently, it may have few or no health effects. However, it is also associated with an extremely wide variety of dire health conditions, many of which are chronic and/or can be fatal.
About 15 million Americans suffer from an alcohol abuse disorder.
What’s more, only about 6.7% of people who have a drinking problem seek professional help. About 88,000 people die of alcohol-related causes every year. Problem drinking can result in physical dependence on alcohol.
Since alcohol consumption leads to reductions in reaction time, judgment, and decision-making, any episode of drinking can lead to harmful accidents or injury. However, most health risks of alcohol come from problem drinking, including binge drinking.
Conditions associated with long-term alcohol misuse include:
- High blood pressure, stroke, heart attack, and other cardiovascular events
- Cirrhosis (permanent scarring) of the liver caused by alcohol exposure
- A higher risk of certain cancers, including breast, mouth, throat, and liver
- Decline in cognitive performance, especially in learning and memory
- Greater likelihood of mental health complications like anxiety and depression
What Research Currently Exists on the Effects of Alcohol?
For many years, research around alcohol focused on the idea that it had health benefits if used in moderation. However, recent research is casting doubt on these long-held assumptions.
Over the last five years, scientific studies have confirmed the connection between even moderate alcohol use and premature death, cancer, stroke, and high blood pressure. Some studies also suggest that abstaining from alcohol can improve mental health.
In general, a scientific consensus is forming around the idea that zero alcohol consumption is the best approach for individuals who want to safeguard their overall health.
Why Are Further Clinical Trials on the Effects of Alcohol Important?
Alcohol and its risks have been researched extensively. However, there are still many areas where more findings are needed. 40%-60% of people treated for alcoholism eventually relapse. The precise brain chemistry involved in alcoholism and successfully abstaining from problem drinking are not understood. Quality of support for sufferers can be spotty.
A limited number of medications are available to help people with alcoholism. However, these are effective in only a fraction of cases.

Likewise, further research is necessary to support the anecdotal conclusions of treatment organizations, especially faith-based organizations, about the best way to provide social support during long-term treatment.
Current Clinical Trials on the Effects of Alcohol
This is the most recent list of clinical trials on the effects of alcohol submitted to ClinicalTrials.gov.
Alcohol clinical resources are developed by organizations worldwide. Watch this space for further information about alcohol studies that may lead to groundbreaking treatment. If you have a study to include on our site, contact our team.
- Mobile Platform for Optimizing Wellness and Engagement in Recoveryon December 12, 2025 at 5:00 am
Conditions: Opioid Agonist Treatment; Alcohol Use Disorder; Opioid Use Disorder Interventions: Behavioral: Digital Contingency Management Intervention Arm; Behavioral: Digital Wellness Arm Sponsors: University of Michigan; National Institute on Alcohol Abuse and Alcoholism (NIAAA); DynamiCare Health Recruiting
- Suvorexant and Alcoholon December 11, 2025 at 5:00 am
Conditions: Alcohol Use Disorder Interventions: Drug: Alcohol; Drug: Placebo; Drug: Suvorexant; Drug: Suvorexant Sponsors: University of Kentucky; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- Optimizing HIV Pre-exposure Prophylaxis (PrEP) Among Women Who Use Drugs in Tanzaniaon December 11, 2025 at 5:00 am
Conditions: HIV; Mental Health; Substance Use (Drugs, Alcohol) Interventions: Behavioral: Motivational Interviewing for PreP; Behavioral: Common Elements Treatment Approach (CETA) + MI-PrEP Sponsors: Johns Hopkins Bloomberg School of Public Health; Muhimbili University of Health and Allied Sciences; National Institute on Drug Abuse (NIDA) Recruiting
- Environment and Alcohol: A Pilot Studyon December 11, 2025 at 5:00 am
Conditions: Alcohol Use Disorder Interventions: Behavioral: Evaluate the effects of Environmental Enrichment (EE) on alcohol consumption Sponsors: National Institute on Drug Abuse (NIDA) Recruiting
- Prazosin for Alcohol Use Disorder With Withdrawal Symptomson December 11, 2025 at 5:00 am
Conditions: Alcohol Withdrawal Interventions: Drug: Prazosin; Behavioral: 12-Step Facilitation with Relapse Prevention and Contingency Management Sponsors: Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)on December 11, 2025 at 5:00 am
Conditions: Alcohol Use Disorder Interventions: Drug: Intravenous Ethanol; Drug: 18F-PF-06445974 Sponsors: National Institute of Mental Health (NIMH) Recruiting
- Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinkingon December 11, 2025 at 5:00 am
Conditions: Alcohol Use Disorder Interventions: Drug: Suvorexant 10 mg; Other: Placebo Sponsors: Ohio State University; National Institute on Alcohol Abuse and Alcoholism (NIAAA) Recruiting
- SMART-r: Substance Monitoring and Active Relapse Tracking Repositoryon December 11, 2025 at 5:00 am
Conditions: Alcoholism; Substance-Related Disorders Sponsors: National Institute on Drug Abuse (NIDA) Recruiting
- Alcohol Use Disorder Before and After Bariatric Surgery and the Impact of Considering This Surgery During Addiction Follow-upon December 10, 2025 at 5:00 am
Conditions: Alcohol Use Disorder Sponsors: University Hospital, Strasbourg, France Recruiting
- Adaptation of the Family Check-Up Onlineon December 10, 2025 at 5:00 am
Conditions: Substance Use (Drugs, Alcohol) Interventions: Behavioral: Adapted Family Check-Up Online; Behavioral: Original Family Check-Up Online Sponsors: University of Oregon; National Institute on Drug Abuse (NIDA) Recruiting
- Understanding Gene ENvironment Interaction in ALcohol-related Hepatocellular Carcinomaon December 9, 2025 at 5:00 am
Conditions: HCC; Genetic Predisposition Interventions: Other: quantify of risk factors Sponsors: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Recruiting
- Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Buildingon December 9, 2025 at 5:00 am
Conditions: Alcohol Use Disorder (AUD); PTSD Interventions: Behavioral: CBT + expressive writing; Behavioral: Wait-List Control Sponsors: University of Rhode Island; Rhode Island Foundation Recruiting
Conclusion
Alcohol has been part of human history for thousands of years. However, modern medicine still has a long way to go in managing the serious health risks associated with it. More alcohol clinical studies are crucial for discovering the alcohol clinical resources millions of people need to stop drinking.
Content Box
- https://www.drugfreeworld.org/drugfacts/alcohol.html
- https://www.alcoholproblemsandsolutions.org/history-of-alcohol-and-drinking-around-world/
- http://www.drinkingandyou.com/site/us/xdrunk.htm
- http://www.bbc.co.uk/newsbeat/article/30350860/the-science-of-alcohol-how-booze-affects-your-body
- https://www.verywellmind.com/prevalence-of-alcoholism-in-the-united-states-67876
- https://www.cdc.gov/alcohol/fact-sheets/alcohol-use.htm