Hyperinflation Respiratory Therapies in Cardiac Surgery Patients
NCT04164173
Recruiting
The purpose of this prospective randomized clinical trial is to evaluate three different types of hyperinflation respiratory therapies, Intermittent Positive Pressure Breathing (IPPB), Intermittent positive end expiratory pressure (EzPAP), Metaneb. Investigators will examine which hyperinflation therapy provides better lung expansion and may improve lung recovery after surgery.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/28/2024
Locations: UT Southwestern Clements University Hospital, Dallas, Texas
Conditions: Pulmonary Disease, Postoperative Complications
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Oral Nutritional Optimization in Total Joint Arthroplasty
NCT04210284
Recruiting
The purpose of this study is to determine the effect on hematological markers of nutritional intervention on nutritionally deficient patients following total joint replacement surgery.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
10/28/2024
Locations: NYU Langone Health, New York, New York +1 locations
Conditions: Osteoarthritis
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Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure
NCT04502225
Recruiting
Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/28/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Supine Hypertension, Autonomic Failure
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Improving Access and Affordability of Adult Hearing Healthcare
NCT04671381
Recruiting
This project will address quality of care issues associated with hearing loss in adults who have mild-to-moderate hearing loss and who have no access to hearing healthcare. Through the use of three different interventions involving over-the-counter hearing aids, it will lead to options that will increase access and affordability of hearing healthcare for adults with mild-to-moderate hearing loss.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
10/28/2024
Locations: The University of Alabama, Tuscaloosa, Alabama
Conditions: Hearing Loss
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Early Life Stress and Depression: Molecular and Functional Imaging
NCT04713722
Recruiting
Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experiences (they are resilient). In spite of this, little is known about the neurobiological mechanisms related to childhood adversity, especially oxidative stress abnormalities in the brain. To fill this gap,... Read More
Gender:
FEMALE
Ages:
Between 20 years and 32 years
Trial Updated:
10/28/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Depression, Trauma, Psychological
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Twin Block, Pain Medications and Third Molar Extractions
NCT04880707
Recruiting
Each year, over 3.5 million, mostly, healthy young adults, have their third molar teeth ('wisdom teeth') removed under sedation and are often given opioid prescriptions for managing their pain. Wisdom molar removal is one of the most common reasons for opioid prescriptions to be given to adolescents. There is a national thrust to reduce both the dose and the duration of such opioid prescriptions because even short-term opioid exposures increase risk for narcotic addiction and misuse. Non-opioid... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/28/2024
Locations: Rutgers School of Dental Medicine, Newark, New Jersey
Conditions: Acute Pain
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SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)
NCT04885179
Recruiting
This protocol aims to gather information about sphingosine phosphate lyase insufficiency syndrome (SPLIS), also known as NPHS14, and to create a SPLIS patient registry. Medical records, radiological and pathology results, blood test results, and genetic information will be collected. Samples of blood, cheek cells, urine and stool may be collected for analysis. If a skin biopsy has been performed for medical care, cells from the biopsy may be analyzed. No treatment or other intervention is involv... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/28/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Sphingolipidoses, Enzyme Deficiency
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CEDARS Intervention: A Coping, Emotional Development, & Stress Reduction Intervention
NCT04958694
Recruiting
Using an adapted stress-reduction intervention called the CEDARS, the investigators will pilot the intervention in adolescents (N=40) to determine the feasibility and acceptability of CEDARS implementation and to investigate adolescent stress reduction. As an exploratory aim, the investigators will explore the influence of the CEDARS on CMH-related behaviors and CMH. The investigators expect that those adolescents who undergo the intervention will have the greatest improvement in mental health s... Read More
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
10/28/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Adolescent Behavior, Stress Reduction, Adverse Childhood Experiences, Positive Attitude
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Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
NCT05184569
Recruiting
The purpose of the study is to test the safety and tolerability of twice daily Verdiperstat in patients with semantic variant primary progressive aphasia (svPPA) due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Three-fourths of the participants will receive Verdiperstat and one-fourth will receive Placebo during the 24-week treatment duration.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/28/2024
Locations: UCSF Memory and Aging Center, San Francisco, California +4 locations
Conditions: Semantic Dementia
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Topical Insulin for Glaucoma
NCT05206877
Recruiting
The purpose of this Phase 1 trial is to determine the safety over 1-2 months of topic sterile human recombinant insulin on subjects with optic neuropathies (glaucoma, ischecmic optic neuropathy, and optic disc drusen).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/28/2024
Locations: Byers Eye Institute at Stanford University, Palo Alto, California
Conditions: Glaucoma
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Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma
NCT05352672
Recruiting
This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called REGN2810, also known as cemiplimab (each individually called a "study drug" or called "study drugs" when combined). The study is focused on patients with a type of skin cancer known as melanoma. The aims of the study are to see how effective the combination of fianlimab and cemiplimab are in treating the melanoma skin cancer, in comparison with a medicati... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
10/28/2024
Locations: University of California San Diego, La Jolla, California +218 locations
Conditions: Melanoma
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HSAT for OSA Management in Children
NCT05516524
Recruiting
This clinical trial will compare the diagnostic accuracy of type II HSAT with PSG for determining OSA status following treatment with adenotonsillectomy in children
Gender:
ALL
Ages:
Between 5 years and 12 years
Trial Updated:
10/28/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sleep Apnea, Obstructive, Sleep Disorder, Sleep Apnea Syndromes, Sleep Disturbance
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