Delaware is currently home to 281 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Newark, Wilmington, Lewes and Rehoboth Beach. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Central Sodium Sensing: Implications for Blood Pressure Regulation
NCT05480722
Recruiting
The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the human brain in older adults and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pre... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
12/07/2023
Locations: William B Farquhar, Newark, Delaware
Conditions: Salt Sensitivity of Blood Pressure
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Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics
NCT04233957
Recruiting
High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.
Gender:
ALL
Ages:
Between 21 years and 45 years
Trial Updated:
11/28/2023
Locations: Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware
Conditions: Sodium Excess
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Determinants of Changes in Arterial Load Following Exercise
NCT05820243
Recruiting
The goal of this study is to learn about how blood vessel dilation after exercise effects pulse wave reflection and influences the function of the heart in healthy young adults. The main question it aims to answer is: Are post-exercise decreases in reflected pulse waves due to a decrease in the stiffness of large arteries in the leg or an increase in leg blood flow? Participants will exercise on a stationary bicycle at a moderate intensity for 1 hour during two laboratory visits. Participants wi... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
11/27/2023
Locations: Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware
Conditions: Post-Exercise Hypotension
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Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy
NCT00680264
Recruiting
The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
11/20/2023
Locations: A.I. Dupont Hospital for Children, Wilmington, Delaware
Conditions: Cerebral Palsy, Scoliosis
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The Pediatric Anesthesia Quality Improvement Project
NCT00674388
Recruiting
The Study is designed to collect information about adverse events that occur in children undergoing anesthesia in participating hospitals. Demographic information will be collected on all anesthetics. An analysis of each adverse event will be performed and entered into the database. From this information we will devise strategies to prevent these adverse events.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
11/20/2023
Locations: Nemours/Alfred I duPont Hospital for Children, Wilmington, Delaware
Conditions: Surgery, Anesthesia, Children
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Development and Validation of a Novel Eye-Tracking Software-based Platform to Extract Oculometric Measures
NCT05476523
Recruiting
This is an observational prospective study in a cohort of healthy subjects who are enrolled using convenience and snowballing sampling. The aims of the study is to demonstrate the efficacy of using NeuraLight system to capture oculometric data from healthy participants and to validate the data capture of NeuraLight oculometric measurements as compared with a validated eye-tracker system in subjects who meet the inclusion criteria and who provide a signed Informed Consent.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/07/2023
Locations: NeuraLight, Wilmington, Delaware
Conditions: Eye Movement
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EASE: The Materna Prep Pivotal Study
NCT03973281
Recruiting
This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery. Subjects are randomized to Materna Prep Device or Standard of Care without use of the Materna Prep Device Intervention with the Materna Prep Device is expected to be a one-time use of approximately 30-90 minutes during the 1st stage of labor. Subject participation in the study is targeted to be 12 months from the time of the use of the device d... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: Christiana Care - Center for Women's & Children's Health, Newark, Delaware
Conditions: Vaginal Delivery, Pelvic Organ Prolapse
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Model-informed Patient-specific Rehabilitation Using Robotics and Neuromuscular Modeling
NCT06008743
Recruiting
Stroke is the third leading cause of death and the primary cause of long-term disability in the United States, affecting approximately 795,000 people each year. Hemiparesis, or unilateral weakness, is common after stroke and responsible for changes in muscle activation and movement patterns as well as declines in walking speed. It has been shown that increased walking speed directly corresponds to a higher quality of life in older adults and therefore, is often the goal of motor rehabilitation a... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/20/2023
Locations: University of Delaware, Newark, Delaware
Conditions: Stroke
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Recasting or Book Reading by Parents or Clinicians
NCT05099328
Recruiting
Developmental Language Disorder (DLD) affects approximately seven percent of the population and is characterized by grammatical deficits that cascade into lifelong academic challenges and under-employment. Current treatments for DLD produce good outcomes under ideal, high intensity conditions or when parents have been trained to deliver therapy using intense coaching methods; however, current publicly funded service delivery systems and private-pay reimbursement models do not support treatment b... Read More
Gender:
ALL
Ages:
Between 4 years and 9 years
Trial Updated:
08/16/2023
Locations: University of Delaware, Newark, Delaware
Conditions: Developmental Language Disorder and Language Impairment
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The Effect of Guided Care With Vectra Compared to Treatment as Usual in Patients With Rheumatoid Arthritis
NCT03631225
Recruiting
The goal of treating patients diagnosed with rheumatoid arthritis (RA) is to achieve remission or low disease activity and thereby prevent joint damage, loss of physical function, and disability. Optimal management requires regular assessment of disease activity, with treatment changes made as needed for optimal efficacy. Vectra is a blood serum test that looks at 12 biomarkers and produces a score on a scale of 1 to 100. The Vectra score has been shown to be the strongest predictor of risk for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Delaware Arthritis, Lewes, Delaware
Conditions: Rheumatoid Arthritis (RA)
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Vaginal Care System for Menopausal Women With Urinary Tract Infections
NCT05573334
Recruiting
Menopausal women have an increased risk of recurrent urinary tract infections. This is likely due in part to hormonal changes occurring during menopause. As estrogen falls, the vaginal microbiome shifts from a healthy one to a less healthy one. Because the vagina is close to the urethra, this vaginal microbiome shift contributes to a loss of protection against urinary tract infections (UTIs). The investigators are asking whether improving the vaginal microbiome using an over-the-counter vaginal... Read More
Gender:
FEMALE
Ages:
89 years and below
Trial Updated:
07/17/2023
Locations: Center for Urogynecology & Pelvic Reconstructive Surgery, Newark, Delaware
Conditions: Urinary Tract Infections, Vaginal Flora Imbalance
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Simple Bone Cysts in Kids
NCT02193841
Recruiting
Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one is better than another. The purpose of this research trial is to compare the effectiveness of two common treatments that are used by surgeons today.
Gender:
ALL
Ages:
Between 2 years and 21 years
Trial Updated:
07/10/2023
Locations: Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware
Conditions: Bone Cyst
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