Healthy Clinical Trials in Tempe, AZ

The main aim of this study is to find out how several doses of TAK-279 affects the body of healthy adults and processes midazolam and repaglinide (pharmacokinetics or PK). Another aim is to learn about the side effects of TAK-279 and how well it is tolerated when given to healthy adults either alone or together with midazolam or repaglinide. During the study, participants will need to stay at the clinic for 19 days. Blood samples will be taken at several timepoints during the study. The study drug will be given by mouth (orally). Read Less

The purposes of this Phase 1 study of EDG-7500 are to: Learn about the safety of EDG-7500 after a single and multiple doses in healthy adults Learn about how EDG-7500 is tolerated after a single and multiples doses in healthy adults Evaluate the amount of EDG-7500 is in the blood and urine after single and multiple doses in healthy adults Evaluate the effect of a meal on the amount of EDG-7500 that is in the blood in healthy adults Evaluate whether the amount of EDG-7500 in the blood is similar for the suspension and tablet forms of EDG-7500 in healthy adults Participants will receive a single or multiple doses of EDG-7500 or a placebo by mouth. Read Less

The purpose of VAN00010 study is to assess the safety and immunogenicity of the investigational pentavalent meningococcal ABCYW vaccine in adults and adolescents. The study duration will be up to 12 months for all participants. Read Less

Stuttering negatively impacts communication and reduces the overall quality of life and well-being of individuals who stutter. This study will provide a strong foundation for developing neural and behavioral interventions for stuttering. Participants will be asked to name pictures, read words/sentences silently or aloud, and listen to speech and nonspeech sounds while their speech, muscle, and brain signals are collected. Some participants may also receive brain stimulation while reading and speaking. Read Less

This study in healthy volunteers will provide a basis for evaluation of TRL345 as a first in human study, specifically, important safety, tolerability, and pharmacokinetic data, and provide serum samples for ex vivo studies of concentration-dependent antiviral activity to support the dose selection for as well as design and conduct of a clinical study in transplant patients. Read Less

The aim of this research is to develop protocols that selectively target and improve speech-motor learning processes. Participants will be asked to name pictures, read words/sentences, and listen to sounds while their speech signals will be collected during the study. Read Less

The purposes of this study are to: Learn about the safety and tolerability of CK 4021586 after a single dose and multiple doses in healthy subjects. Find out how much CK-4021586 is in the blood after a single dose and multiple doses. Determine the effect different doses of CK-4021586 on the pumping function of the heart. Determine the effect of food in the stomach on how much CK-4021586 is in the blood after a single dose. Read Less