There are currently 32 active clinical trials seeking participants for Cardiovascular Diseases research studies. The states with the highest number of trials for Cardiovascular Diseases participants are .
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
NCT03142152
Recruiting
The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating heart failure with functional regurgitation (FMR).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Dignity Health Research Institute at Mercy Gilbert and Chandler Regional Medical Centers, Gilbert, Arizona +70 locations
Conditions: Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
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A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
NCT07064473
Recruiting
This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empagliflozin, helps reduce cardiovascular risk in people with these conditions. The study will compare this combination to a placebo version of vicadrostat with empagliflozin. Participants are put into 2 gro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +1056 locations
Conditions: Diabetes Mellitus, Type 2, Hypertension, Cardiovascular Diseases
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Extended-Release Tacrolimus Following Liver Transplantation
NCT05242315
Recruiting
Medications used after transplant to prevent rejection are associated with many side effects. Tacrolimus side effects include kidney dysfunction; tremor, headaches, difficulty sleeping, change in sensation (legs), seizure, or confusion; high blood pressure; anemia, or low blood cell counts; diabetes; abnormal cholesterol and weight gain. The investigators want to use a new, approved, formulation of the standard medication (Envarsus) as they believe it may be associated with reduced side effects.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Univerity of Alberta, Edmonton, Alberta
Conditions: Liver Transplant; Complications, Renal Insufficiency, Immunosuppressant Adverse Reaction, Metabolic Syndrome, Cardiovascular Diseases
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Higher vs. Lower Dose Heparin for PCI
NCT04049591
Recruiting
HD PCI is a multicenter, randomized, registry-based, cluster crossover design trial of higher dose versus lower dose heparin in patients undergoing elective percutaneous coronary intervention (PCI).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Hamilton Health Sciences, General Hospital, Hamilton, Ontario
Conditions: Cardiovascular Diseases, Percutaneous Coronary Intervention
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COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes
NCT05633810
Recruiting
To evaluate the efficacy and safety of colchicine and non-enteric coated aspirin, combined or alone, to improve cardiovascular outcomes in high-risk patients with type 2 diabetes.
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
06/11/2025
Locations: Montreal Heart Institute, Montréal, Quebec
Conditions: Diabete Type 2, Cardiovascular Diseases
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Studying the Effects of Cannabis on Vasculature
NCT05581368
Recruiting
Cannabis is commonly used globally. It is associated with psychiatric problems, but the effects on the cardiovascular system are unclear. In this project, the investigators plan to study the effects of cannabis on the cardiovascular system. This will be done by using a non-invasive test to measure blood vessel function and by using blood samples to measure inflammation. As a control for this project, the investigators would like to test the blood vessel function and inflammation levels of partic... Read More
Gender:
ALL
Ages:
Between 19 years and 80 years
Trial Updated:
06/11/2025
Locations: London Regional Health Science Centre, London, Ontario
Conditions: Cardiovascular Diseases, Inflammation, Atherosclerosis
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Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism
NCT04263038
Recruiting
The clinical significance of pulmonary embolism (PE) limited to the subsegmental pulmonary arteries, so called isolated subsegmental pulmonary embolism (SSPE), remains controversial. Whether isolated SSPE represents "true" PE, a clinically more benign form of PE, a physiologic lung clearing process, or a false positive result (artifact) is currently unclear and hence, whether patients with isolated SSPE benefit from anticoagulant treatment is uncertain. Despite growing evidence from observationa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Centre hospitalier universitaire de Liege, Liège, Not set +38 locations
Conditions: Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases, Cardiovascular Diseases, Respiratory Tract Diseases, Venous Thromboembolism, Anticoagulant-induced Bleeding, Bleeding
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Aggressive Smoking Cessation Trial (ASAP)
NCT05257629
Recruiting
The ASAP Trial is a 5-year, multi-centre, randomized controlled trial that will assess the efficacy, safety, and tolerability of aggressive smoking cessation therapy among people at elevated cardiovascular risk. It will recruit 798 adult patients smoking on average at least 10 conventional (tobacco) cigarettes per day who are motivated to quit smoking and have either been diagnosed with ACS requiring hospitalization or are outpatients at elevated cardiovascular risk. Patients will be randomized... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: Fraser Clinical Trials, New Westminster, British Columbia +12 locations
Conditions: Acute Coronary Syndrome, Cardiovascular Diseases
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Passive Heat Therapy for People With COPD
NCT05962164
Recruiting
People with Chronic Obstructive Pulmonary Disease (COPD) often develop high blood pressure and heart disease due to their sedentary lifestyle and difficulty exercising. The investigators will test if heating can mimic the health benefits of exercise by monitoring the increase in leg blood-flow using ultrasound during a 45-minute hot-water footbath. The patients will then undergo 6-weeks of hot-water footbaths to examine whether the changes to blood-flow lead to improvements in blood pressure and... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
04/02/2025
Locations: University of British Columbia, Kelowna, British Columbia
Conditions: COPD, Cardiovascular Diseases
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Micro-doses of Physical Activity for COPD
NCT05553223
Recruiting
Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than healthy individuals. Those who are the most sedentary have a greater risk of heart and blood vessel disease, which may lead to an early death. This project will investigate the effect of sitting still for 3 hours on blood vessel health in individuals with COPD. It will also in... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/02/2025
Locations: University of British Columbia, Kelowna, British Columbia
Conditions: Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction, Vascular Stiffness, Hypertension, Cardiovascular Diseases
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Testing VIRTUES Patient Care Sets in Cardiac Patients (VIRTUES Cardiac Care)
NCT05452356
Recruiting
Patients with various cardiac conditions (such as those who experience a heart attack) are increasing in Canada and are in need of appropriate cardiac rehabilitation and care. Many patients do not have access to local in-person cardiac clinics, particularly in rural regions of Canada. A user-friendly digital application with accessible educational resources and recommendations based on the most up to date clinical practice guidelines can help mitigate these issues. VIRTUES is a digital healthcar... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: London Health Sciences Centre, London, Ontario
Conditions: Heart Diseases, Arrhythmias, Cardiac, Atrial Fibrillation, Cardiovascular Diseases, Pathologic Processes
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Carotid Intraplaque Neovascularization Combined with Stress Echo
NCT05416385
Recruiting
The root cause of heart attacks and strokes is atherosclerosis, the hardening and thickening of blood vessels due to the presence of "plaque" which is a build-up of fat and cholesterol in the walls of vessels. To diagnose heart disease, patients receive a stress test to find out if they require surgery. Up to 52% of patients receiving an angiogram (surgery) to look at plaque blockages in the heart are found to be normal (no blockage). Patients who are suspected of having heart disease often unde... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: University of Calgary, Calgary, Alberta +5 locations
Conditions: Atherosclerosis, Cardiovascular Diseases, Acute Coronary Syndrome, Ischemic Heart Disease, Myocardial Infarction, Carotid Artery Diseases
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