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Chronic Lymphocytic Leukemia Clinical Trials in Canada
A listing of 13 Chronic Lymphocytic Leukemia clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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There are currently 13 active clinical trials seeking participants for Chronic Lymphocytic Leukemia research studies. The states with the highest number of trials for Chronic Lymphocytic Leukemia participants are .
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
Recruiting
This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help t... Read More
This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +618 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Anchorage Associates in Radiation Medicine, Anchorage, Alaska
Anchorage Radiation Therapy Center, Anchorage, Alaska
Alaska Breast Care and Surgery LLC, Anchorage, Alaska
Alaska Oncology and Hematology LLC, Anchorage, Alaska
Alaska Women's Cancer Care, Anchorage, Alaska
Anchorage Oncology Centre, Anchorage, Alaska
Katmai Oncology Group, Anchorage, Alaska
Providence Alaska Medical Center, Anchorage, Alaska
Fairbanks Memorial Hospital, Fairbanks, Alaska
Cancer Center at Saint Joseph's, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
Mercy Hospital Fort Smith, Fort Smith, Arkansas
CHI Saint Vincent Cancer Center Hot Springs, Hot Springs, Arkansas
Kaiser Permanente-Anaheim, Anaheim, California
Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande, California
Kaiser Permanente-Baldwin Park, Baldwin Park, California
Kaiser Permanente-Bellflower, Bellflower, California
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California
Marshall Cancer Center, Cameron Park, California
Mercy Cancer Center - Carmichael, Carmichael, California
Mercy San Juan Medical Center, Carmichael, California
UC Irvine Health Cancer Center-Newport, Costa Mesa, California
City of Hope Comprehensive Cancer Center, Duarte, California
Mercy Cancer Center - Elk Grove, Elk Grove, California
Kaiser Permanente-Fontana, Fontana, California
Kaiser Permanente South Bay, Harbor City, California
City of Hope Seacliff, Huntington Beach, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
City of Hope at Irvine Lennar, Irvine, California
Kaiser Permanente-Irvine, Irvine, California
UCI Health Laguna Hills, Laguna Hills, California
City of Hope Antelope Valley, Lancaster, California
City of Hope at Long Beach Elm, Long Beach, California
Tibor Rubin VA Medical Center, Long Beach, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Kaiser Permanente West Los Angeles, Los Angeles, California
Fremont - Rideout Cancer Center, Marysville, California
City of Hope Newport Beach, Newport Beach, California
Kaiser Permanente-Ontario, Ontario, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
Kaiser Permanente - Panorama City, Panorama City, California
Kaiser Permanente-Riverside, Riverside, California
Mercy Cancer Center - Rocklin, Rocklin, California
Mercy Cancer Center - Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Kaiser Permanente-San Diego Zion, San Diego, California
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo, California
Kaiser Permanente-San Marcos, San Marcos, California
Mission Hope Medical Oncology - Santa Maria, Santa Maria, California
City of Hope South Pasadena, South Pasadena, California
City of Hope South Bay, Torrance, California
City of Hope Upland, Upland, California
Kaiser Permanente-Woodland Hills, Woodland Hills, California
Woodland Memorial Hospital, Woodland, California
Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado
The Medical Center of Aurora, Aurora, Colorado
Boulder Community Foothills Hospital, Boulder, Colorado
Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado
Rocky Mountain Cancer Centers - Centennial, Centennial, Colorado
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado
Cancer Center of Colorado at Sloan's Lake, Denver, Colorado
National Jewish Health-Main Campus, Denver, Colorado
The Women's Imaging Center, Denver, Colorado
AdventHealth Porter, Denver, Colorado
Colorado Blood Cancer Institute, Denver, Colorado
Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado
Rocky Mountain Cancer Centers-Midtown, Denver, Colorado
Saint Joseph Hospital - Cancer Centers of Colorado, Denver, Colorado
Rocky Mountain Cancer Centers-Rose, Denver, Colorado
Rose Medical Center, Denver, Colorado
Western Surgical Care, Denver, Colorado
CommonSpirit Cancer Center Mercy, Durango, Colorado
Mercy Medical Center, Durango, Colorado
Mountain Blue Cancer Care Center - Swedish, Englewood, Colorado
Rocky Mountain Cancer Centers - Swedish, Englewood, Colorado
Swedish Medical Center, Englewood, Colorado
The Melanoma and Skin Cancer Institute, Englewood, Colorado
National Jewish Health-Western Hematology Oncology, Golden, Colorado
Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado
Grand Valley Oncology, Grand Junction, Colorado
Banner North Colorado Medical Center, Greeley, Colorado
Good Samaritan Hospital - Cancer Centers of Colorado, Lafayette, Colorado
Rocky Mountain Cancer Centers-Lakewood, Lakewood, Colorado
Saint Anthony Hospital, Lakewood, Colorado
Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado
AdventHealth Littleton, Littleton, Colorado
Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree, Colorado
Sky Ridge Medical Center, Lone Tree, Colorado
Longmont United Hospital, Longmont, Colorado
Rocky Mountain Cancer Centers-Longmont, Longmont, Colorado
Banner McKee Medical Center, Loveland, Colorado
AdventHealth Parker, Parker, Colorado
Saint Mary Corwin Medical Center, Pueblo, Colorado
National Jewish Health-Northern Hematology Oncology, Thornton, Colorado
Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado
Beebe Medical Center, Lewes, Delaware
Beebe South Coastal Health Campus, Millville, Delaware
Delaware Clinical and Laboratory Physicians PA, Newark, Delaware
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
Beebe Health Campus, Rehoboth Beach, Delaware
TidalHealth Nanticoke / Allen Cancer Center, Seaford, Delaware
Christiana Care Health System-Wilmington Hospital, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Sibley Memorial Hospital, Washington, District of Columbia
Holy Cross Hospital, Fort Lauderdale, Florida
Sacred Heart Hospital, Pensacola, Florida
Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho
Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho
Walter Knox Memorial Hospital, Emmett, Idaho
Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho
Idaho Urologic Institute-Meridian, Meridian, Idaho
Saint Luke's Cancer Institute - Meridian, Meridian, Idaho
Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Nampa, Nampa, Idaho
Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint, Idaho
Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho
OSF Saint Anthony's Health Center, Alton, Illinois
Rush-Copley Medical Center, Aurora, Illinois
Illinois CancerCare-Bloomington, Bloomington, Illinois
Loyola Center for Health at Burr Ridge, Burr Ridge, Illinois
Illinois CancerCare-Canton, Canton, Illinois
Memorial Hospital of Carbondale, Carbondale, Illinois
SIH Cancer Institute, Carterville, Illinois
Illinois CancerCare-Carthage, Carthage, Illinois
Centralia Oncology Clinic, Centralia, Illinois
Northwestern University, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Carle at The Riverfront, Danville, Illinois
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Illinois CancerCare-Dixon, Dixon, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Illinois CancerCare-Eureka, Eureka, Illinois
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois
Illinois CancerCare-Galesburg, Galesburg, Illinois
Western Illinois Cancer Treatment Center, Galesburg, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois
Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois
Ingalls Memorial Hospital, Harvey, Illinois
NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois
Loyola Medicine Homer Glen, Homer Glen, Illinois
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
Illinois CancerCare-Macomb, Macomb, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park, Illinois
SSM Health Good Samaritan, Mount Vernon, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois
Cancer Care Center of O'Fallon, O'Fallon, Illinois
University of Chicago Medicine-Orland Park, Orland Park, Illinois
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois
Illinois CancerCare-Pekin, Pekin, Illinois
Illinois CancerCare-Peoria, Peoria, Illinois
Methodist Medical Center of Illinois, Peoria, Illinois
Illinois CancerCare-Peru, Peru, Illinois
Valley Radiation Oncology, Peru, Illinois
Edward Hospital/Cancer Center?Plainfield, Plainfield, Illinois
Illinois CancerCare-Princeton, Princeton, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
The Carle Foundation Hospital, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Illinois CancerCare - Washington, Washington, Illinois
Rush-Copley Healthcare Center, Yorkville, Illinois
UChicago Medicine Northwest Indiana, Crown Point, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Reid Health, Richmond, Indiana
Mary Greeley Medical Center, Ames, Iowa
McFarland Clinic - Ames, Ames, Iowa
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
McFarland Clinic - Boone, Boone, Iowa
Saint Anthony Regional Hospital, Carroll, Iowa
Physicians' Clinic of Iowa PC, Cedar Rapids, Iowa
Mercy Cancer Center-West Lakes, Clive, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Alegent Health Mercy Hospital, Council Bluffs, Iowa
Greater Regional Medical Center, Creston, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
Broadlawns Medical Center, Des Moines, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
Iowa Lutheran Hospital, Des Moines, Iowa
McFarland Clinic - Trinity Cancer Center, Fort Dodge, Iowa
UI Healthcare Mission Cancer and Blood - Fort Dodge, Fort Dodge, Iowa
McFarland Clinic - Jefferson, Jefferson, Iowa
McFarland Clinic - Marshalltown, Marshalltown, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa
Methodist West Hospital, West Des Moines, Iowa
Mercy Medical Center-West Lakes, West Des Moines, Iowa
Central Care Cancer Center - Garden City, Garden City, Kansas
Central Care Cancer Center - Great Bend, Great Bend, Kansas
HaysMed, Hays, Kansas
University of Kansas Cancer Center, Kansas City, Kansas
Lawrence Memorial Hospital, Lawrence, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
Flaget Memorial Hospital, Bardstown, Kentucky
Commonwealth Cancer Center-Corbin, Corbin, Kentucky
Saint Joseph Radiation Oncology Resource Center, Lexington, Kentucky
Saint Joseph Hospital East, Lexington, Kentucky
Saint Joseph London, London, Kentucky
Jewish Hospital, Louisville, Kentucky
Saints Mary and Elizabeth Hospital, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
Jewish Hospital Medical Center South, Shepherdsville, Kentucky
Hematology/Oncology Clinic PLLC, Baton Rouge, Louisiana
Ochsner LSU Health Monroe Medical Center, Monroe, Louisiana
Tulane University School of Medicine, New Orleans, Louisiana
Ochsner LSU Health Saint Mary's Medical Center, Shreveport, Louisiana
LSU Health Sciences Center at Shreveport, Shreveport, Louisiana
Harold Alfond Center for Cancer Care, Augusta, Maine
Mid Coast Hospital, Brunswick, Maine
MaineHealth Maine Medical Center - Portland, Portland, Maine
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland, Maine
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Hickman Cancer Center, Adrian, Michigan
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
Bronson Battle Creek, Battle Creek, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan
Trinity Health Medical Center - Canton, Canton, Michigan
Caro Cancer Center, Caro, Michigan
Chelsea Hospital, Chelsea, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan
Hematology Oncology Consultants-Clarkston, Clarkston, Michigan
Newland Medical Associates-Clarkston, Clarkston, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Henry Ford Medical Center-Fairlane, Dearborn, Michigan
Henry Ford Hospital, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Henry Ford River District Hospital, East China Township, Michigan
Cancer Hematology Centers - Flint, Flint, Michigan
Genesee Hematology Oncology PC, Flint, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Henry Ford Saint John Hospital - Academic, Grosse Pointe Woods, Michigan
Henry Ford Saint John Hospital - Breast, Grosse Pointe Woods, Michigan
Henry Ford Saint John Hospital - Van Elslander, Grosse Pointe Woods, Michigan
Allegiance Health, Jackson, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Beacon Kalamazoo Cancer Center, Kalamazoo, Michigan
Beacon Kalamazoo, Kalamazoo, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
Hope Cancer Clinic, Livonia, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Henry Ford Saint John Hospital - Macomb Medical, Macomb, Michigan
Henry Ford Warren Hospital - Breast Macomb, Macomb, Michigan
Saint Mary's Oncology/Hematology Associates of Marlette, Marlette, Michigan
Toledo Clinic Cancer Centers-Monroe, Monroe, Michigan
Trinity Health Muskegon Hospital, Muskegon, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
Hope Cancer Center, Pontiac, Michigan
Michigan Healthcare Professionals Pontiac, Pontiac, Michigan
Newland Medical Associates-Pontiac, Pontiac, Michigan
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan
Corewell Health Reed City Hospital, Reed City, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Oncology Hematology Associates of Saginaw Valley PC, Saginaw, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
Henry Ford Macomb Health Center - Shelby Township, Shelby, Michigan
Henry Ford Health Providence Southfield Hospital, Southfield, Michigan
Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights, Michigan
MyMichigan Medical Center Tawas, Tawas City, Michigan
Munson Medical Center, Traverse City, Michigan
Advanced Breast Care Center PLLC, Warren, Michigan
Henry Ford Health Warren Hospital, Warren, Michigan
Henry Ford Madison Heights Hospital - Breast, Warren, Michigan
Henry Ford Warren Hospital - GLCMS, Warren, Michigan
Macomb Hematology Oncology PC, Warren, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
Saint Mary's Oncology/Hematology Associates of West Branch, West Branch, Michigan
University of Michigan Health - West, Wyoming, Michigan
Huron Gastroenterology PC, Ypsilanti, Michigan
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan
Fairview Ridges Hospital, Burnsville, Minnesota
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Cambridge Medical Center, Cambridge, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Essentia Health - Deer River Clinic, Deer River, Minnesota
Essentia Health Cancer Center, Duluth, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Unity Hospital, Fridley, Minnesota
Essentia Health Hibbing Clinic, Hibbing, Minnesota
Fairview Clinics and Surgery Center Maple Grove, Maple Grove, Minnesota
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota
Saint John's Hospital - Healtheast, Maplewood, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
Minneapolis VA Medical Center, Minneapolis, Minnesota
Health Partners Inc, Minneapolis, Minnesota
Monticello Cancer Center, Monticello, Minnesota
New Ulm Medical Center, New Ulm, Minnesota
Fairview Northland Medical Center, Princeton, Minnesota
North Memorial Medical Health Center, Robbinsdale, Minnesota
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
Essentia Health Sandstone, Sandstone, Minnesota
Saint Francis Regional Medical Center, Shakopee, Minnesota
Lakeview Hospital, Stillwater, Minnesota
Essentia Health Virginia Clinic, Virginia, Minnesota
Ridgeview Medical Center, Waconia, Minnesota
Rice Memorial Hospital, Willmar, Minnesota
Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota
Fairview Lakes Medical Center, Wyoming, Minnesota
Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus, Mississippi
Baptist Cancer Center-Grenada, Grenada, Mississippi
Baptist Memorial Hospital and Cancer Center-Union County, New Albany, Mississippi
Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven, Mississippi
Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin, Missouri
Central Care Cancer Center - Bolivar, Bolivar, Missouri
Mercy Cancer Center - Cape Girardeau, Cape Girardeau, Missouri
Saint Francis Medical Center, Cape Girardeau, Missouri
Saint Luke's Hospital, Chesterfield, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Parkland Health Center - Farmington, Farmington, Missouri
MU Health Care Goldschmidt Cancer Center, Jefferson City, Missouri
Freeman Health System, Joplin, Missouri
Mercy Hospital Joplin, Joplin, Missouri
University Health Truman Medical Center, Kansas City, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
Heartland Regional Medical Center, Saint Joseph, Missouri
Mercy Infusion Center - Chippewa, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital South, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
Missouri Baptist Sullivan Hospital, Sullivan, Missouri
BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri
Mercy Hospital Washington, Washington, Missouri
Community Hospital of Anaconda, Anaconda, Montana
Billings Clinic Cancer Center, Billings, Montana
Saint Vincent Healthcare, Billings, Montana
Saint Vincent Frontier Cancer Center, Billings, Montana
Bozeman Health Deaconess Hospital, Bozeman, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Great Falls Clinic, Great Falls, Montana
Logan Health Medical Center, Kalispell, Montana
Saint Patrick Hospital - Community Hospital, Missoula, Montana
Community Medical Center, Missoula, Montana
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island, Nebraska
CHI Health Good Samaritan, Kearney, Nebraska
Saint Elizabeth Regional Medical Center, Lincoln, Nebraska
Cancer Partners of Nebraska, Lincoln, Nebraska
Alegent Health Immanuel Medical Center, Omaha, Nebraska
Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska
Alegent Health Lakeside Hospital, Omaha, Nebraska
Creighton University Medical Center, Omaha, Nebraska
Midlands Community Hospital, Papillion, Nebraska
OptumCare Cancer Care at Seven Hills, Henderson, Nevada
OptumCare Cancer Care at Charleston, Las Vegas, Nevada
OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Cooper Hospital University Medical Center, Camden, New Jersey
Jersey City Medical Center, Jersey City, New Jersey
Monmouth Medical Center Southern Campus, Lakewood, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Community Medical Center, Toms River, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Presbyterian Kaseman Hospital, Albuquerque, New Mexico
Memorial Medical Center-Las Cruces, Las Cruces, New Mexico
Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho, New Mexico
Hematology Oncology Associates of Central New York-Auburn, Auburn, New York
Hematology Oncology Associates of CNY at Camillus, Camillus, New York
Memorial Sloan Kettering Commack, Commack, New York
Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York
Glens Falls Hospital, Glens Falls, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Upstate Cancer Center at Oswego, Oswego, New York
Rochester General Hospital, Rochester, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
SUNY Upstate Medical Center-Community Campus, Syracuse, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Upstate Cancer Center at Verona, Verona, New York
Wilmot Cancer Institute at Webster, Webster, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Southeastern Medical Oncology Center-Clinton, Clinton, North Carolina
Durham VA Medical Center, Durham, North Carolina
Duke University Medical Center, Durham, North Carolina
Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina
Margaret R Pardee Memorial Hospital, Hendersonville, North Carolina
University of North Carolina-Hillsborough Campus, Hillsborough, North Carolina
Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina
ECU Health Oncology Kenansville, Kenansville, North Carolina
ECU Health Oncology Kinston, Kinston, North Carolina
ECU Health Oncology Richlands, Richlands, North Carolina
Indu and Raj Soin Medical Center, Beavercreek, Ohio
Strecker Cancer Center-Belpre, Belpre, Ohio
Saint Elizabeth Boardman Hospital, Boardman, Ohio
Cleveland Clinic Mercy Hospital, Canton, Ohio
Dayton Physicians LLC-Miami Valley South, Centerville, Ohio
Miami Valley Hospital South, Centerville, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio
Oncology Hematology Care Inc-Kenwood, Cincinnati, Ohio
Bethesda North Hospital, Cincinnati, Ohio
TriHealth Cancer Institute-Westside, Cincinnati, Ohio
TriHealth Cancer Institute-Anderson, Cincinnati, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Mount Carmel East Hospital, Columbus, Ohio
Columbus Oncology and Hematology Associates Inc, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
Grant Medical Center, Columbus, Ohio
The Mark H Zangmeister Center, Columbus, Ohio
Mount Carmel Health Center West, Columbus, Ohio
Doctors Hospital, Columbus, Ohio
Miami Valley Hospital, Dayton, Ohio
Dayton Physician LLC - Englewood, Dayton, Ohio
Miami Valley Hospital North, Dayton, Ohio
Delaware Health Center-Grady Cancer Center, Delaware, Ohio
Grady Memorial Hospital, Delaware, Ohio
Dublin Methodist Hospital, Dublin, Ohio
Armes Family Cancer Center, Findlay, Ohio
Blanchard Valley Hospital, Findlay, Ohio
Orion Cancer Care, Findlay, Ohio
Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio
Dayton Physicians LLC-Atrium, Franklin, Ohio
Central Ohio Breast and Endocrine Surgery, Gahanna, Ohio
Dayton Physicians LLC-Wayne, Greenville, Ohio
Wayne Hospital, Greenville, Ohio
Mount Carmel Grove City Hospital, Grove City, Ohio
Greater Dayton Cancer Center, Kettering, Ohio
Kettering Medical Center, Kettering, Ohio
Fairfield Medical Center, Lancaster, Ohio
Saint Rita's Medical Center, Lima, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
Marietta Memorial Hospital, Marietta, Ohio
OhioHealth Marion General Hospital, Marion, Ohio
Memorial Hospital, Marysville, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
Knox Community Hospital, Mount Vernon, Ohio
Licking Memorial Hospital, Newark, Ohio
Newark Radiation Oncology, Newark, Ohio
Mercy Health - Perrysburg Hospital, Perrysburg, Ohio
Southern Ohio Medical Center, Portsmouth, Ohio
Springfield Regional Cancer Center, Springfield, Ohio
Springfield Regional Medical Center, Springfield, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
Mercy Health - Saint Vincent Hospital, Toledo, Ohio
Mercy Health - Saint Anne Hospital, Toledo, Ohio
Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio
Dayton Physicians LLC - Troy, Troy, Ohio
Upper Valley Medical Center, Troy, Ohio
Saint Joseph Warren Hospital, Warren, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
Saint Ann's Hospital, Westerville, Ohio
Wright-Patterson Medical Center, Wright-Patterson Air Force Base, Ohio
Saint Elizabeth Youngstown Hospital, Youngstown, Ohio
Genesis Healthcare System Cancer Care Center, Zanesville, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma
Saint Alphonsus Cancer Care Center-Baker City, Baker City, Oregon
Saint Charles Health System, Bend, Oregon
Clackamas Radiation Oncology Center, Clackamas, Oregon
Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon
Bay Area Hospital, Coos Bay, Oregon
Providence Newberg Medical Center, Newberg, Oregon
Saint Alphonsus Cancer Care Center-Ontario, Ontario, Oregon
Providence Willamette Falls Medical Center, Oregon City, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Saint Charles Health System-Redmond, Redmond, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Pocono Medical Center, East Stroudsburg, Pennsylvania
Lehigh Valley Hospital-Hazleton, Hazleton, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Jefferson Torresdale Hospital, Philadelphia, Pennsylvania
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina
Ralph H Johnson VA Medical Center, Charleston, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Cancer Institute - Easley, Easley, South Carolina
Prisma Health Cancer Institute - Butternut, Greenville, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Prisma Health Cancer Institute - Greer, Greer, South Carolina
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina
Bristol Regional Medical Center, Bristol, Tennessee
Ballad Health Cancer Care - Kingsport, Kingsport, Tennessee
Wellmont Holston Valley Hospital and Medical Center, Kingsport, Tennessee
Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Saint Joseph Regional Cancer Center, Bryan, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
STCC at DHR Health Institute for Research and Development, Edinburg, Texas
UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Ballad Health Cancer Care - Bristol, Bristol, Virginia
Ballad Health Cancer Care - Norton, Norton, Virginia
VCU Massey Cancer Center at Stony Point, Richmond, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Providence Regional Cancer System-Aberdeen, Aberdeen, Washington
FHCC Overlake, Bellevue, Washington
PeaceHealth Saint Joseph Medical Center, Bellingham, Washington
Highline Medical Center-Main Campus, Burien, Washington
Providence Regional Cancer System-Centralia, Centralia, Washington
Swedish Cancer Institute-Edmonds, Edmonds, Washington
Saint Elizabeth Hospital, Enumclaw, Washington
Providence Regional Cancer Partnership, Everett, Washington
Saint Francis Hospital, Federal Way, Washington
Swedish Cancer Institute-Issaquah, Issaquah, Washington
Kadlec Clinic Hematology and Oncology, Kennewick, Washington
FHCC at EvergreenHealth, Kirkland, Washington
Providence Regional Cancer System-Lacey, Lacey, Washington
Saint Clare Hospital, Lakewood, Washington
PeaceHealth Saint John Medical Center, Longview, Washington
Jefferson Healthcare, Port Townsend, Washington
Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington
Pacific Gynecology Specialists, Seattle, Washington
Swedish Medical Center-Ballard Campus, Seattle, Washington
Fred Hutchinson Cancer Center, Seattle, Washington
Swedish Medical Center-Cherry Hill, Seattle, Washington
Swedish Medical Center-First Hill, Seattle, Washington
FHCC at Northwest Hospital, Seattle, Washington
University of Washington Medical Center - Montlake, Seattle, Washington
PeaceHealth United General Medical Center, Sedro-Woolley, Washington
Providence Regional Cancer System-Shelton, Shelton, Washington
Saint Michael Cancer Center, Silverdale, Washington
Franciscan Research Center-Northwest Medical Plaza, Tacoma, Washington
Northwest Medical Specialties PLLC, Tacoma, Washington
PeaceHealth Southwest Medical Center, Vancouver, Washington
Providence Saint Mary Regional Cancer Center, Walla Walla, Washington
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington
Providence Regional Cancer System-Yelm, Yelm, Washington
Langlade Hospital and Cancer Center, Antigo, Wisconsin
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Duluth Clinic Ashland, Ashland, Wisconsin
HSHS Sacred Heart Hospital, Eau Claire, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Aspirus Medford Hospital, Medford, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
Cancer Center of Western Wisconsin, New Richmond, Wisconsin
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Cheyenne Regional Medical Center-West, Cheyenne, Wyoming
Billings Clinic-Cody, Cody, Wyoming
Welch Cancer Center, Sheridan, Wyoming
BCCA-Vancouver Cancer Centre, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John, New Brunswick
QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax, Nova Scotia
Lakeridge Health Oshawa, Oshawa, Ontario
Ottawa Hospital and Cancer Center-General Campus, Ottawa, Ontario
Jewish General Hospital, Montreal, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Recruiting
The purpose of Part 1 of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL; participants may or may not have already had treatment for their cancer. The purpose of Part 2 of this study evaluates pirtobrutinib monotherapy in treatment-naïve participants with CLL/SLL with 17p deletions. Participation could last up to six years for Part 1. Participation could last up to 2 years for Part 2.
The purpose of Part 1 of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL; participants may or may not have already had treatment for their cancer. The purpose of Part 2 of this study evaluates pirtobrutinib monotherapy in treatment-naïve participants with CLL/SLL with 17p deletions. Participation could last up to six years for Part 1. Participation could last up to 2 years for Part 2. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: Genesis Cancer Center, Hot Springs, Arkansas +176 locations
Genesis Cancer Center, Hot Springs, Arkansas
Pacific Cancer Medical Center, Inc, Anaheim, California
Alta Bates Summit Medical Center, Berkeley, California
TOI Clinical Research, Cerritos, California
Stanford School of Medicine-Cancer Clinical Trials Office, Palo Alto, California
Eisenhower Army Medical Center, Rancho Mirage, California
Sharp Memorial Hospital, San Diego, California
California Cancer Associates for Research and Excellence, San Marcos, California
Eastern Connecticut Hematology/Oncology Assoc., Norwich, Connecticut
Asclepes Research Centers Florida, Brooksville, Florida
Florida Cancer Specialists, Fort Myers, Florida
Cancer Specialists of North Florida -St Augustine, Jacksonville, Florida
Lakeland Regional Health Systems Inc, Lakeland, Florida
Florida Cancer Specialists, Saint Petersburg, Florida
Florida Cancer Specialists East, West Palm Beach, Florida
Summit Cancer Care, P.C., Savannah, Georgia
Baptist Healthcare System, Inc., Louisville, Kentucky
Hematology Oncology Clinic, Baton Rouge, Louisiana
Tulane Cancer Center Office of Clinical Research, New Orleans, Louisiana
American Oncology Partners of Maryland, PA, Bethesda, Maryland
TidalHealth Peninsula Regional, Inc., Salisbury, Maryland
St. Vincent Frontier Cancer Center, Billings, Montana
Westchester Medical Center, Hawthorne, New York
Novant Cancer Institute Charlotte, Charlotte, North Carolina
The James Cancer Hospital, Columbus, Ohio
Cancer Care Associates of York, York, Pennsylvania
Lifespan Cancer Institute, Providence, Rhode Island
Prisma Health Cancer Institute, Greenville, South Carolina
Sarah Cannon Research Institute SCRI, Chattanooga, Tennessee
Kelsey Research Foundation, Houston, Texas
Houston Methodist Hospital Cancer Center, Houston, Texas
Lumi Research, Kingwood, Texas
Baylor Scott & White Health, Round Rock, Texas
Virginia Cancer Institute, Richmond, Virginia
Summit Cancer Treatment Center, Spokane, Washington
MultiCare Health System Institute for Research and Innovation, Spokane, Washington
Hospital Privado De Comunidad, Mar Del Plata, Buenos Aires
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aire
Instituto Alexander Fleming, Ciudad Autonoma Buenos Aires, Not set
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares, Santa Fe, Not set
Sunshine Hospital, St Albans, Victoria
One Clinical Research, Nedlands, Western Australia
The Perth Blood Institute, West Perth, Not set
Ordensklinikum Linz, Linz, Oberösterreich
Hanusch Krankenhaus, Vienna, Not set
VITAZ, Sint-Niklaas, Oost-Vlaanderen
AZ Delta, Roeselare, West Flanders
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven, Not set
Centro Integrado de Oncologia de Curitiba, Curitiba, Paraná
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba, Paraná
Instituto do Câncer - Hospital São Vicente de Paulo, Passo Fundo, Rio Grande Do Sul
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital Mae de Deus, Porto Alegre, Rio Grande Do Sul
UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu, Botucatu, Sao Paulo
Centro de Hematologia e Hemoterapia - Hemocentro de Campinas - UNICAMP, Campinas, Sao Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto, Sao Jose Rio Preto, Sao Paulo
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, São Paulo
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) - HCFMRP, Ribeirão Preto, São Paulo
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André, São Paulo
Hospital Uopeccan - Centro de Pesquisa Clinica, Cascavel, Not set
Hospital Beneficência Portuguesa de São Paulo, Sao Paulo, Not set
Hospital Santa Marcelina, Sao Paulo, Not set
Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, Not set
Cancer Care Manitoba, Winnipeg, Manitoba
Royal Victoria Regional Health Centre, Barrie, Ontario
Hopital de L'Enfant Jesus, Québec, Not set
Sociedad de Investigaciones Médicas Limitada, Temuco, IX Región
CeCim Biocinetic, Santiago, Región Metropolitana
Centro de Estudios Clinicos SAGA, Providencia, Santiago
Centro de Investigaciones Clínicas Viña del Mar (CIC), Viña del Mar, Valparaíso
Anhui Provincial Hospital, Hefei, Anhui
The Second Hospital of Anhui Medical University, Hefei, Anhui
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong
Southern Medical University Nanfang Hospital, Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi
Wu Han Tongji Hospital, Wuhan City, Hubei
The 2nd Xiangya Hospital of Central South University, Changsha, Hunan
Hunan Cancer Hospital, Changsha, Hunan
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
Jiangxi Provincial Cancer Hospital, Nanchang, Jiangxi
Fudan University Shanghai Cancer Center, Shanghai, Shanghai
Blood Institute of the Chinese Academy of Medical science, Tianjin, Tianjin
Tianjin Medical University General Hospital, Tianjin, Tianjin
The Affiliated Cancer Hospital of Xinjiang Medical university, Urumqi, Xinjiang
The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang
Hainan General Hospital, Haikou, Not set
First Affiliated Hosp of College of Med, Zhejiang University, Hangzhou, Not set
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Not set
Fakultni nemocnice Brno, Brno, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni Nemocnice Ostrava, Ostrava-Poruba, Not set
Fakultni Nemocnice Plzen, Plzen - Lochotin, Not set
Fakultni nemocnice Kralovske Vinohrady, Praha 10, Not set
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Hopital de la Pitie Salpetriere, Paris, Cedex 13
CHU de Nantes - Hotel Dieu, Nantes, Cedex 1
Hôpital de Pontchaillou, Rennes, Cedex 9
Centre Hospitalier Lyon Sud, Pierre Benite, Cedex
Centre Antoine Lacassagne, Nice, Nice Cedex 2
CHRU De Tours, Tours, Tours Cedex 9
CHD Vendee, La Roche sur Yon, Not set
Centre Hospitalier du Mans, Le Mans, Not set
Centre Hospitalier Universitaire (Limoges) (CHU DUPUYTREN 1), Limoges, Not set
Centre Henri Becquerel, Rouen Cedex, Not set
Universitaetsklinikum Ulm, Ulm, Baden
Uniklinik Köln, Kerpener, Köln
GEFOS (Gesellschaft für onkologische Studien) Dortmund mbH, Dortmund, Nordrhein Westfalen
Gemeinschaftspraxis Haematologie und Onkologie, Dresden, Sachsen Anhalt
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden, Sachsen
Debreceni Egyetem, Debrecen, Not set
Markusovszky Egyetemi Oktatokorhaz, Szombathely, Not set
Hadassah Medical Center, Jerusalem, Not set
Rabin Medical Center-Beilinson Campus, Petach-Tikva, Not set
Chaim Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
IRCCS Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori "Dino Amadori" - IRST, Meldola, Forlì-Cesena
A.O.U. Citta' della Salute e della Scienza di Torino, Torino, Otago
Fondazione del Piemonte per l'Oncologia IRCCS Candiolo, Candiolo, Torino
Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Not set
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS, Bologna, Not set
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Milano, Not set
IRCCS Ospedale San Raffaele, Milano, Not set
IEO Istituto Europeo di Oncologia, Milano, Not set
Azienda Unita Sanitaria Locale di Reggio Emilia, Reggio Emilia, Not set
Centro Ricerche Cliniche di Verona s.r.l., Verona, Not set
Tokai University Hospital- Isehara Campus, Isehara, Kanagawa
Kumamoto University Hospital, Kumamoto, Not set
Yamagata University Hospital, Yamagata, Not set
Seoul National University Hospital, Seoul, Seoul, Korea
The Catholic University of Korea-Seoul St. Mary's Hospital, Seocho-Gu, Seoul
Inje Univ Busan Paik Hospital, Busan, Not set
Samsung Medical Center, Seoul, Not set
P3 Research, Newtown, Wellington
Dunedin Hospital, Dunedin, Not set
Waikato Hospital, Hamilton, Not set
Middlemore Hospital, Otahuhu, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Pomorskie
Centrum Medyczne Pratia Poznan, Skorzewo, Poznan
KO-MED Centra Kliniczne, Biała Podlaska, Not set
Szpital Uniwersytecki nr 2 im. dr Jana Biziela w BydgoszczyKlinika Hematologii, Bydgoszcz, Not set
Pratia Onkologia Katowice, Katowice, Not set
Pratia MCM Krakow, Krakow, Not set
Klinika Hematoonkologii i Transplantacji Szpiku, Lublin, Not set
Szpital Wojewodzki w Opolu, Opole, Not set
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu Klinika Hematologii, Wrocław, Not set
Institut Català d'Oncologia de Girona (ICO Girona), Girona, Cataluna
Hospital Germans Trias i Pujol, Badalona, Catalunya [Cataluña]
Hospital Universitari Vall d'Hebron, Barcelona, Cataluña
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Hospital Costa Del Sol, Marbella, Malaga
Hospital De Navarra, Pamplona, Navarra
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Duran i Reynals, L'Hospitalet de Llobregat, Not set
Hospital De Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Not set
Clinica Universitaria De Navarra, Madrid, Not set
Hospital Universitario Infanta Leonor, Madrid, Not set
Hospital Universitario Ramón y Cajal, Madrid, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Chang Gung Memorial Hospital - Chiayi, Putz, Chiayi Hsien
Chang Bing Show Chwan Memorial Hospital, Changhua, Not set
National Cheng Kung University Hospital, Tainan, Not set
Koo Foundation Sun Yan-Sen Cancer Center, Taipei, Not set
Ankara University Medicine Hospital, Mamak, Ankara
9 Eylul University Hospital, Balçova, İzmir
Ege University Medical Faculty, Bornova, Izmir
Gazi University Faculty of Medicine, Ankara, Yenimahalle
Koc University American Hospital, Istanbul, Not set
Acıbadem Maslak Hastanesi, Istanbul, Not set
Istanbul University Istanbul Medical Faculty, Istanbul, Not set
Bristol Haematology and Oncology Centre, Bristol, Bristol, City Of
Castle Hill Hospital, Hull, East Riding Of Yorkshire
Leicester Royal Infirmary, Leicester, Leicestershire
St Bartholomew's Hospital, London, London, City Of
Singleton Hospital, Swansea, Not set
Conditions: Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma
A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies
Recruiting
Study consists of two main parts to explore BGB-16673 recommended dosing, a Phase 1 monotherapy dose finding comprised of monotherapy dose escalation and monotherapy safety expansion of selected doses, and a Phase 2 (expansion cohorts)
Study consists of two main parts to explore BGB-16673 recommended dosing, a Phase 1 monotherapy dose finding comprised of monotherapy dose escalation and monotherapy safety expansion of selected doses, and a Phase 2 (expansion cohorts) Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: University of Alabama At Birmingham Hospital, Birmingham, Alabama +116 locations
University of Alabama At Birmingham Hospital, Birmingham, Alabama
Western Regional Medical Center, Llc, Goodyear, Arizona
Mayo Clinic Phoenix, Phoenix, Arizona
Honor Health Research Institute, Scottsdale, Arizona
University of Arizona Cancer Center, Tucson, Arizona
University of California San Diego (Ucsd) Moores Cancer Center, La Jolla, California
Stanford Medicine, Palo Alto, California
UCLA Santa Monica Cancer Care, Santa Monica, California
Uchealth North, Fort Collins, Colorado
Mayo Clinic Jacksonville, Jacksonville, Florida
Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida
Tampa General Hospital Cancer Institute, Tampa, Florida
Augusta University, Augusta, Georgia
Southeastern Regional Medical Center, Newnan, Georgia
Midwestern Regional Medical Center, Zion, Illinois
University of Iowa Hospitals and Clinics, Iowa City, Iowa
Norton Cancer Institute Pavilion, Louisville, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
American Oncology Partners of Maryland Pa, Bethesda, Maryland
Dana Farber Cancer Institute, Boston, Massachusetts
Karmanos Cancer Institute, Detroit, Michigan
Mayo Clinic Rochester, Rochester, Minnesota
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Roswell Park Comprehensive Cancer Center, Buffalo, New York
Columbia University Medical Center, New York, New York
Weill Cornell Medical College Newyork Presbyterian Hospital, New York, New York
Memorial Sloan Kettering Cancer Center Mskcc, New York, New York
Tennesse Oncology Chattanooga, Chattanooga, Tennessee
Tennessee Oncology, Pllc Nashville, Nashville, Tennessee
Md Anderson Cancer Center, Houston, Texas
Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia
Fred Hutchinson Cancer Research Center, Seattle, Washington
Concord Repatriation General Hospital, Concord, New South Wales
Calvary Mater Newcastle, Waratah, New South Wales
Princess Alexandra Hospital, Woolloongabba, Queensland
St Vincents Hospital Melbourne, Fitzroy, Victoria
Peninsula Private Hospital, Frankston, Victoria
Austin Health, Heidelberg, Victoria
Peter Maccallum Cancer Centre, Melbourne, Victoria
The Alfred Hospital, Melbourne, Victoria
Linear Clinical Research, Nedlands, Western Australia
Perth Blood Institute, West Perth, Western Australia
Hospital Sirio Libanes Brasilia, Brasilia, Not set
Instituto de Pesquisa Em Saude Da Universidade de Caxias Do Sul, Caxias do Sul, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre, Not set
Hospital Ernesto Dornelles, Porto Alegre, Not set
Real E Benemerita Associacao Portuguesa de Sao Paulo, Sao Paulo, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
Hospital Nove de Julho Dasa, Sao Paulo, Not set
Instituto Dor de Pesquisa E Ensino Sao Paulo, Sao Paulo, Not set
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, Sao Paulo, Not set
Hospital Santa Rita de Cassia Afecc, Vitoria, Not set
Cross Cancer Institute, Edmonton, Alberta
British Columbia Cancer Agency the Vancouver Centre, Vancouver, British Columbia
Princess Margaret Cancer Centre, Toronto, Ontario
Arthur Je Child Comprehensive Cancer Centre, Calgary, Not set
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic), Quebec, Not set
Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux, Not set
Hopital Estaing, Clermontferrand, Not set
Chu Henri Mondor, Creteil, Not set
Hopital Claude Huriez Chu Lille, Lille, Not set
Centre Leon Berard, Lyon Cedex, Not set
Institut Paoli Calmettes, Marseille, Not set
Chu Montpellier Hopital Saint Eloi, Montpellier, Not set
Hopital de La Pitie Salpetriere, Paris, Not set
Centre Henri Becquerel, Rouen Cedex, Not set
Arensia Exploratory Medicine Llc, Tbilisi, Not set
Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden, Dresden, Not set
Uniklinik Koeln (Aoer), Koln, Not set
Universitares Krebszentrum Leipzig, Leipzig, Not set
Universitaetsklinikum Schleswig Holstein Campus Luebeck, Luebeck, Not set
Klinikum Johannes Gutenberg Universitaet Mainz, Mainz, Not set
Klinikum Grosshadern Ludwig Maximilians Universitat Munchen, Munchen, Not set
Universitaetsklinikum Ulm, Ulm, Not set
Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna, Not set
Ospedale San Raffaele, Milano, Not set
Istituto Europeo Di Oncologia, Milano, Not set
Niguarda Cancer Center Division of Hematology, Milano, Not set
Fondazione Policlinico Universitario Agostino Gemelli, Roma, Not set
Centroricerche Cliniche Di Verona Srl, Verona, Not set
Aichi Cancer Center Hospital Clinical Oncology, Nagoya, Aichi
Chiba Cancer Center, Chibashi, Chiba
National Cancer Center Hospital East, Kashiwa, Chiba
Cancer Institute Hospital of Jfcr, Kotoku, Tokyo
Yokohama Municipal Citizens Hospital, YokohamaShi, Not set
Inje University Busan Paik Hospital, BusanjinGu, Busan Gwang'yeogsi
Pusan National University Hospital, SeoGu, Busan Gwang'yeogsi
Samsung Medical Center, GangnamGu, Seoul Teugbyeolsi
The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi
Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Asan Medical Center, SongpaGu, Seoul Teugbyeolsi
The Institute of Oncology, Arensia Exploratory Medicine, Chisinau, Not set
Hospital Universitario Vall Dhebron, Barcelona, Not set
Hospital de La Santa Creu I Sant Pau, Barcelona, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Md Anderson Cancer Center Madrid Spain, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Sahlgrenska University Hospital Hematology, Goteborg, Not set
Karolinska Universitetssjukhuset Solna, Stockholm, Not set
Uppsala Akademiska Sjukhus, Uppsala, Not set
Ankara University, Abidinpaa, Not set
Dr Abdurrahman Yurtaslan Research and Training Hospital, Ankara, Not set
Dokuz Eylul University, Balcova, Not set
Erciyes University, Kayseri, Not set
Sakarya Training and Research Hospital, Sakarya, Not set
Ondokuz Mayis University, Samsun, Not set
Edinburgh Cancer Centre, Edinburgh, Not set
Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set
St Jamess University Hospital, Leeds, Not set
Freeman Hospital, NewCastle Upon Tyne, Not set
Nottingham University Hospitals Nhs Trust, Nottingham, Not set
Derriford Hospital, Plymouth, Not set
Conditions: B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-hodgkin Lymphoma, Waldenström Macroglobulinemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Diffuse Large B Cell Lymphoma
A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
Recruiting
The purpose of this study is to investigate the efficacy and safety of BGB-16673 compared with investigator's choice (idelalisib plus rituximab \[for CLL only\] or bendamustine plus rituximab or venetoclax plus rituximab retreatment) in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) previously exposed to both BTK inhibitors (BTKi) and BCL2 inhibitors (BCL2i).
The purpose of this study is to investigate the efficacy and safety of BGB-16673 compared with investigator's choice (idelalisib plus rituximab \[for CLL only\] or bendamustine plus rituximab or venetoclax plus rituximab retreatment) in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) previously exposed to both BTK inhibitors (BTKi) and BCL2 inhibitors (BCL2i). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: St Bernards Medical Center, Jonesboro, Arkansas +121 locations
St Bernards Medical Center, Jonesboro, Arkansas
UCLA Department of Medicine Hematologyoncology, Los Angeles, California
Pih Health Whittier Hospital, Whittier, California
Rocky Mountain Cancer Centers (Williams) Usor, Aurora, Colorado
Florida Oncology and Hematology, Fort Myers, Florida
Cleveland Clinic Florida, Weston, Florida
Emory University Winship Cancer Institute, Atlanta, Georgia
Our Lady of the Lake Hospital, Baton Rouge, Louisiana
American Oncology Partners of Maryland Pa, Bethesda, Maryland
Corewell Health the Michigan Cancer Consortium, Grand Rapids, Michigan
Oncology Hematology Associates, Springfield, Missouri
Oncology Hematology West, Pc Dba Nebraska Cancer Specialists, Omaha, Nebraska
Memorial Sloan Kettering Cancer Center Mskcc, New York, New York
Clinical Research Alliance, Inc, Westbury, New York
University Hospitals, Cleveland, Ohio
Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene, Oregon
Cancer Care Associates of York, York, Pennsylvania
Texas Oncology Tyler, Tyler, Texas
Wvu Medicine, Wheeling Hospital, Wheeling, West Virginia
Hospital Aleman, Caba, Not set
FUNDALEU, Caba, Not set
Hospital Italiano de Buenos Aires, Ciudad Autonoma Buenos Aires, Not set
Instituto Alexander Fleming (Iaf), Ciudad Autonoma Buenos Aires, Not set
Concord Repatriation General Hospital, Concord, New South Wales
Gosford Hospital, Gosford, New South Wales
Port Macquarie Base Hospital, Port Macquarie, New South Wales
Toowoomba Hospital, Toowoomba, Queensland
Flinders Medical Centre, Bedford PK, South Australia
The Alfred Hospital, Melbourne, Victoria
Perth Blood Institute, West Perth, Western Australia
CETUS, Belo Horizonte, Not set
Hospital Sirio Libanes Brasilia, Brasilia, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen), Florianopolis, Not set
Instituto Joinvilense de Hematologia E Oncologia, Joinville, Not set
Complexo Hospitalar de Niteroi, Niteroi, Not set
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre, Not set
Hospital Sao Lucas Dasa Oncologia, Rio de Janeiro, Not set
Oncoclinicas Rio de Janeiro Sa, Rio de Janeiro, Not set
Instituto Brasileiro de Controle Do Cancer, Sao Paulo, Not set
Instituto Dor de Pesquisa E Ensino Sao Paulo, Sao Paulo, Not set
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, Sao Paulo, Not set
Hospital Santa Rita de Cassia Afecc, Vitoria, Not set
London Health Sciences Centre, London, Ontario
The Ottawa Hospital Cancer Centre, Ottawa, Ontario
Centre Integre de Sante Et de Services Sociaux de La Monteregie Centre, Greenfield Park, Quebec
Jewish General Hospital, Montreal, Quebec
Unite de Recherche Clinique Du Cisss Des Laurentides, SaintJerome, Quebec
Fakultni Nemocnice Brno, Brno, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni Nemocnice Ostrava, Ostrava, Not set
Vseobecna Fakultni Nemocnice V Praze, Praha, Not set
Universitatsklinikum Augsburg, Augsburg, Not set
Praxis Am Volkspark, Berlin, Not set
Klinikum Chemnitz Ggmbh, Chemnitz, Not set
Universitatsklinikum Essen (Aor), Essen, Not set
Centrum Fur Haematologie Und Onkologie Bethanien, Frankfurt am Main, Not set
Universitatsklinikum Freiburg I Br Klinik Fur Innere Medizin I, Freiburg im Breisgau, Not set
Universitatsklinikum Hamburg Eppendorf, Hamburg, Not set
Universitatsklinikum Heidelberg, Heidelberg, Not set
Saarland University Medical Center, Homburg, Not set
Invo Institut Fur Versorgungsforschung in Der Onkologie, Koblenz, Not set
Universitaetsklinikum Leipzig Aor, Leipzig, Not set
Universitatsklinikum Munster Medizinische Klinik A, Munster, Not set
Krankenhaus Der Barmherzigen Bruder, Regensburg, Not set
Irccs Istituto Tumori Giovanni Paolo Ii, Bari, Not set
Aou Careggi, Servizio Sanitario Toscana, Firenze, Not set
Fondazione Irccs Ca Granda Ospedale Maggiore Policlinico, Milano, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Ospedaliera Universitaria Federico Ii, Napoli, Not set
Aou Maggiore Della Carita, Novara, Not set
Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi, Pavia, Not set
Ospedale Santa Maria Della Misericordia, Perugia, Not set
Fondazione Policlinico Universitario Agostino Gemelli, Roma, Not set
Aichi Cancer Center Hospital Clinical Oncology, Nagoya, Aichi
Chiba Cancer Center, Chibashi, Chiba
National Cancer Center Hospital East, Kashiwa, Chiba
Nho Shikoku Cancer Center, MatsuyamaShi, Ehime
Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshimashi, Hiroshima
Aiiku Hospital, SapporoShi, Hokkaido
Hyogo Prefectural Amagasaki General Medical Center, AmagasakiCity, Hyogo
Kagoshima University Hospital, Kagoshimashi, Kagoshima
University Hospital, Kyoto Prefectural Univ of Medicine, KyotoShi, Kyoto
Tohoku University Hospital, Sendaishi, Miyagi
Niigata University Medical and Dental Hospital, Niigatashi, Niigata
Kurashiki Central Hospital, Kurashikishi, Okayama
Kansai Medical University Hospital, Hirakata, Osaka
Kindai University Hospital, Osakasayama, Osaka
Saitama Medical Center, Kawagoeshi, Saitama
Ntt Medical Center Tokyo, Shinagawaku, Tokyo
Kumamoto University Hospital, Kumamoto, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Dong A University Hospital, SeoGu, Busan Gwang'yeogsi
Kyungpook National University Hospital, JungGu, Daegu Gwang'yeogsi
National Cancer Center (Korea), IlsandongGu GoyangSi, Gyeonggi-do
Chonnam National University Hwasun Hospital, HwasunGun, Jeollanam-do
Samsung Medical Center, GangnamGu, Seoul Teugbyeolsi
The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Amsterdam Umc Vu Mc, Amsterdam, Not set
Radboud Universitair Medisch Centrum, Nijmegen, Not set
North Shore Hospital, Auckland, Not set
Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny, Brzozow, Not set
Pratia Onkologia Katowice, Katowice, Not set
Pratia McM Krakow, Krakow, Not set
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz, Not set
Uniwersytecki Szpital Kliniczny Nr W Lublinie, Lublin, Not set
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu, Wroclaw, Not set
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Not set
Gazi University, Ankara, Not set
Dokuz Eylul University, Balcova, Not set
Antalya Memorial Hospital, Dokuma, Not set
Sakarya Training and Research Hospital, Sakarya, Not set
Aberdeen Royal Infirmary, Aberdeen, Not set
Birmingham Heartlands Hospital, Birmingham, Not set
The Royal Bournemouth and Christchurch Hospitals Nhs Foundation, Bournemouth, Not set
Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set
University College Hospital, London, Not set
Royal Marsden Hospital, London, Not set
Nottingham University Hospitals Nhs Trust, Nottingham, Not set
Southampton General Hospital, Southampton, Not set
Conditions: CLL, Chronic Lymphocytic Leukemia
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Recruiting
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Chao Family Comprehensive Cancer Center, Orange, California +175 locations
Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute, Palo Alto, California
Scripps Prebys Cancer Center, San Diego, California
Rocky Mountain Cancer Centers (Williams) Usor, Aurora, Colorado
Yale University, Yale Cancer Center, New Haven, Connecticut
Eastern Connecticut Hematology and Oncology, Norwich, Connecticut
Cleveland Clinic Florida, Weston, Florida
Northwestern University, Chicago, Illinois
Illinois Cancer Specialists (Niles) Usor, Niles, Illinois
Mission Cancer and Blood, Waukee, Iowa
University of Louisville, Brown Cancer Center, Louisville, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Dana Farber Cancer Institute, Boston, Massachusetts
The Cancer and Hematology Centers, Grand Rapids, Michigan
Mayo Clinic Rochester, Rochester, Minnesota
Memorial Sloan Kettering Cancer Center Mskcc, New York, New York
Clinical Research Alliance, Inc, Westbury, New York
University of North Carolina At Chapel Hill, Chapel Hill, North Carolina
Levine Cancer Center, Charlotte, North Carolina
Oncology Hematology Care Clinical Trials, Llc, Cincinnati, Ohio
Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene, Oregon
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
Upmc Hillman Cancer Center(Univ of Pittsburgh), Pittsburgh, Pennsylvania
Tennessee Oncology, Nashville, Tennessee
Texas Oncology Baylorcharles A Sammons Cancer Center, Dallas, Texas
Ut Southwestern Medical Center, Dallas, Texas
Texas Oncology San Antonio Medical Center Usor, San Antonio, Texas
Texas Oncology Tyler, Tyler, Texas
Northwest Cancer Specialist, Pc(Us Oncology Research), Vancouver, Washington
Hospital Aleman, Caba, Not set
FUNDALEU, Caba, Not set
Instituto Alexander Fleming (Iaf), Ciudad Autonoma Buenos Aires, Not set
Blacktown Cancer and Haematology Centre, Blacktown, New South Wales
St George Hospital, Kogarah, New South Wales
Northern Nsw Health District, Lismore, New South Wales
Macquarie University, North Ryde, New South Wales
Genesiscare North Shore, St Leonards, New South Wales
Wollongong Private Hospital, Wollongong, New South Wales
Sunshine Coast Hospital and Health Service, Birtinya, Queensland
Princess Alexandra Hospital, Woolloongabba, Queensland
Monash Health, Clayton, Victoria
St Vincents Hospital Melbourne, Fitzroy, Victoria
Peter Maccallum Cancer Centre, Melbourne, Victoria
The Alfred Hospital, Melbourne, Victoria
Rockingham Hospital, Cooloongup, Western Australia
Perth Blood Institute, West Perth, Western Australia
Medizinische Universitatsklinik Innsbruck, Innsbruck, Not set
Medical University Vienna Oncology, Wien, Not set
Hanusch Krankenhaus, Wien, Not set
Cliniques Universitaires Saint Luc, Brussels, Not set
Uz Antwerpen, Edegem, Not set
University Hospitals Leuven, Leuven, Not set
CETUS, Belo Horizonte, Not set
Universidade de Campinas Centro de Hematologia E Hemoterapia, Campinas, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Complexo Hospitalar de Niteroi, Niteroi, Not set
Irmandade Da Santa Casa de Misericordia Hospital Porto Alegre, Porto Alegre, Not set
Hospital Sao Lucas, Rio de Janeiro, Not set
Instituto Dor de Pesquisa E Ensino Rio de Janeiro, Rio de Janeiro, Not set
Hospital Santa Izabel, Salvador, Not set
Hospital Samaritano Sao Paulo, Sao Paulo, Not set
Hospital Nove de Julho Dasa, Sao Paulo, Not set
Instituto Brasileiro de Controle Do Cancer, Sao Paulo, Not set
Instituto Dor de Pesquisa E Ensino Sao Paulo, Sao Paulo, Not set
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular, Sao Paulo, Not set
Hospital Santa Rita de Cassia Afecc, Vitoria, Not set
Cross Cancer Institute, Edmonton, Alberta
British Columbia Cancer Agency the Vancouver Centre, Vancouver, British Columbia
Cancercare Manitoba, Winnipeg, Manitoba
Newfoundland and Labrador Health Services, St Johns, Newfoundland and Labrador
The Ottawa Hospital, Ottawa, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Ciusss Nim Hscm, Montreal, Quebec
Arthur Je Child Comprehensive Cancer Centre, Calgary, Not set
China Japan Friendship Hospital, Beijing, Beijing
Fujian Provincial Hospital, Fuzhou, Fujian
Fujian Medical University Union Hospitalqishan Branch, Fuzhou, Fujian
The First Affiliated Hospital of Xiamen University, Xiamen, Fujian
Guangzhou First Peoples Hospital, Guangzhou, Guangdong
Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong
Guangxi Medical University Cancer Hospital Wuxiang Branch, Nanning, Guangxi
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia
Zhongda Hospital Southeast University, Nanjing, Jiangsu
Suzhou Municipal Hospitalbaita Branch, Suzhou, Jiangsu
Affiliated Hospital of Jiangnan University South Campus, Wuxi, Jiangsu
Northern Jiangsu Peoples Hospital, Yangzhou, Jiangsu
Jiangxi Cancer Hospital, Nanchang, Jiangxi
Liaoning Cancer Hospital and Institute, Shenyang, Liaoning
Shaanxi Provincial Peoples Hospital, Xian, Shaanxi
Shandong Provincial Hospital, Jinan, Shandong
Jining No Peoples Hospital West Branch, Jining, Shandong
The Affiliated Hospital of Qingdao University Branch West Coast, Qingdao, Shandong
Affiliated Zhongshan Hospital of Fudan University, Shanghai, Shanghai
West China Hospital, Sichuan University, Chengdu, Sichuan
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch, Tianjin, Tianjin
The Affiliated Peoples Hospital of Ningbo University, Ningbo, Zhejiang
Taizhou Hospital of Zhejiang Province (East), Taizhou, Zhejiang
Fakultni Nemocnice Brno, Brno, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Vseobecna Fakultni Nemocnice V Praze, Praha, Not set
Ustav Hematologie A Krevni Transfuze (Uhkt), Praha, Not set
University Hospital of Aalborg, Denmark, Aalborg, Not set
Rigshospitalet, Copenhagen, Not set
Odense University Hospital, Odense C, Not set
Zealand University Hospital, Roskilde, Roskilde, Not set
Chu Clermont Ferrand Therapie Cellulaire and Hematolo, Clermontferrand, Not set
Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes, Not set
Hopital de La Pitie Salpetriere, Paris, Not set
Chu Hopital Lyon Sud, PierreBenite, Not set
Hopital Robert Debre, Reims, Not set
Chu Rennes, Rennes Cedes, Not set
Centre Henri Becquerel, Rouen Cedex, Not set
Icans Institut de Cancerologie Strasbourg Europe, Strasbourg, Not set
Iuct Oncopole, Toulouse, Not set
Chu Nancy Hopital Brabois, VandoeuvrelesNancy, Not set
Osp Kurfuerstendamm, Berlin, Not set
Gokos Gmbh, Dresden, Not set
Universitatsklinikum Jena Klinik Fur Innere Medizin Ii, Jena, Not set
Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Not set
Uniklinik Koeln (Aoer), Koln, Not set
Klinikum Der Universitat Munchen Medizinische Klinik Und Poliklinik Iii, Munchen, Not set
Stauferklinikum Schwabisch Gmund Kliniken Ostalb, Mutlangen, Not set
Dietrich Bonhoeffer Klinikum Neubrandenburg, Neubrandenburg, Not set
Medizinische Universitaetsklinik, Tubingen, Not set
Universitaetsklinikum Ulm, Ulm, Not set
Haematologisch Onkologische Schwerpunktpraxis, Wurzburg, Not set
Mater Misericordiae University Hospital, Dublin, Not set
St Jamess Hospital, Dublin, Not set
University Hospital Galway, Galway, Not set
University Hospital Limerick, Limerick, Not set
Azienda Ospedaliera Policlinico Di Bari, Bari, Not set
Ao Brotzu Ospedale Oncologico Armando Businco, Cagliari, Not set
Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Catania, Not set
Azienda Ospedaliero Universitaria Di Ferrara, Ferrara, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set
Universita Degli Studi Di Modena Azienda Ospedaliere Policlinco, Modena, Not set
Asl Salerno Andrea Tortora, Pagani, Not set
Pusan National University Hospital, SeoGu, Busan Gwang'yeogsi
Seoul National University Bundang Hospital, BundangGu SeongnamSi, Gyeonggi-do
National Cancer Center (Korea), IlsandongGu GoyangSi, Gyeonggi-do
Samsung Medical Center, GangnamGu, Seoul Teugbyeolsi
The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi
Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Flevoziekenhuis, Almere, Not set
Rijnstate, Arnhem, Not set
Albert Schweitzer Ziekenhuis, Dordrecht, Not set
Tergooi Mc, Hilversum, Not set
North Shore Hospital, Auckland, Not set
Auckland City Hospital, Auckland, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz, Not set
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu, Torun, Not set
Centralny Szpital Kliniczny Uck Wum, Warszawa, Not set
Uniwersytecki Szpital Kliniczny Hematology, Wroclaw, Not set
Vall D Hebron Institute of Oncology Vhio, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Ico Lhospitalet Hospital Duran I Reynals, Lhospitalet de Llobregat, Not set
Hospital de La Princesa, Madrid, Not set
Hospital Universitario Infanta Leonor, Madrid, Not set
Costa Del Sol (Marbella, Malaga), Marbella, Not set
Hospital Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Hospital Virgen de Valme (Sevilla), Sevilla, Not set
Sahlgrenska University Hospital Hematology, Goteborg, Not set
Skanes Universitetssjukhus I Lund, Lund, Not set
Karolinska Universitetssjukhuset Solna, Stockholm, Not set
Uppsala Akademiska Sjukhus, Uppsala, Not set
University Hospitals Dorset Royal Bournemouth Hospital, Bournemouth, Not set
Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set
St Jamess University Hospital, Leeds, Not set
Kings College Hospital, London, Not set
Freeman Hospital, NewCastle Upon Tyne, Not set
Clatterbridge Cancer Centre, Wirral, Not set
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
A Long-term Extension Study of PCI-32765 (Ibrutinib)
Recruiting
The purpose of this study is to collect long-term safety and efficacy data for participants treated with ibrutinib and to provide ongoing access to ibrutinib for participants who are currently enrolled in ibrutinib studies that have been completed according to the parent protocol, are actively receiving treatment with ibrutinib, and who continue to benefit from ibrutinib treatment.
The purpose of this study is to collect long-term safety and efficacy data for participants treated with ibrutinib and to provide ongoing access to ibrutinib for participants who are currently enrolled in ibrutinib studies that have been completed according to the parent protocol, are actively receiving treatment with ibrutinib, and who continue to benefit from ibrutinib treatment. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2025
Locations: City of Hope Cancer Center, Duarte, California +173 locations
City of Hope Cancer Center, Duarte, California
University of California San Diego Medical Center, La Jolla, California
University of California Los Angeles, Los Angeles, California
St. Joseph Hospital Center for Cancer Prevention and Treatment, Orange, California
Stanford University Medical Center, Stanford, California
Stanford University, Stanford, California
Norwalk Medical Group, Norwalk, Connecticut
Northwest Georgia Oncology Centers PC, Marietta, Georgia
Northwestern University Hospital, Chicago, Illinois
Indiana University, Goshen, Indiana
Kansas University Medical Center, Westwood, Kansas
Louisville Oncology Suburban - Norton Cancer Institute, Louisville, Kentucky
Dana Farber Cancer Center, Boston, Massachusetts
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Battle Creek Health Systm, Battle Creek, Michigan
Karmanos Cancer Institute - Wayne State University, Detroit, Michigan
Washington University, Saint Louis, Missouri
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Weill Medical College of Cornell University, New York, New York
Memorial Sloan-Kettering Cancer Center, New York, New York
Southeastern Medical Oncology Center, Goldsboro, North Carolina
The Ohio State University- James Cancer Hospital, Columbus, Ohio
Willamette Valley Cancer Center, Eugene, Oregon
Kaiser Permanente, Portland, Oregon
University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Avera Medical Group, Sioux Falls, South Dakota
MD Anderson Cancer Center - University of Texas, Houston, Texas
University of Virginia, Charlottesville, Virginia
University of Washington, Seattle, Washington
West Virginia University, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center - Wisconsin Institute for Medical Research, Madison, Wisconsin
CEMIC Saavedra, Ciudad Autonoma Buenos Aires, Not set
Fundaleu, Ciudad de Buenos Aires, Not set
Royal Adelaide Hospital, Adelaide, Not set
John Fawkner Cancer Trial Centre, Coburg, Not set
Concord Hospital, Concord, Not set
Austin Health, Heidelberg, Not set
Peter MacCallum Cancer Institute, Melbourne, Not set
Royal Perth Hospital, Perth, Not set
Alfred Hospital, Prahran, Not set
Adventist Health Care Limited trading as San Clinical Trials Unit, Wahroonga, Not set
UZA, Antwerp, Not set
A.Z. Sint Jan, Brugge, Not set
UCL - Saint Luc, Brussels, Not set
UZ Gent - departement oncologie, Gent, Not set
UZ Leuven Gasthuisberg, Leuven, Not set
UCL Mont-Godinne, Yvoir, Not set
Ministerio da Saude Instituto Nacional do Cancer, Rio De Janeiro, Not set
Santa Casa da Misericórdia da Bahia - Hospital Santa Isabel, Salvador, Not set
Instituto de Ensino e Pesquisa São Lucas, Sao Paulo, Not set
Jewish General Hospital, Montreal, Quebec
Peking University People s Hospital, Beijing, Not set
Peking University Third Hospital, Beijing, Not set
Peking University First Hospital, Beijing, Not set
West China Hospital Sichuan University, Chengdu, Not set
Fujian Medical University, Fuzhou, Not set
Sun Yat-sen University Cancer Hospital, Guangzhou, Not set
Zhejiang University First Hospital, Hangzhou, Not set
Ruijin Hospital, Shanghai, Not set
Tangdu hospital the Fourth Military Medical, Shanxi, Not set
The First Affliated Hospital of Soochow University, Suzhou, Not set
The Institute of Hematological disease, Tianjin, Not set
Wuhan Union Hospital, Wuhan, Not set
Fundacion Santa Fe, Bogota, Not set
Fundacion Oftalmologica de Santander - FOSCAL, Floridablanca, Not set
Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika, Brno, Not set
Fakultni nemocnice Kralovske Vinohrady - Interni hematologicka klinika, Praha 10, Not set
Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie, Praha 2, Not set
Hopital Henri Mondor, Creteil, Not set
Hôpital E. Muller, Mulhouse, Not set
Hopital Necker Enfants Malades, Paris cedex 15, Not set
HOPITAL SAINT LOUIS - Hematology / Oncology, Paris, Not set
Hopital Haut Leveque Service Maladie Du Sang, Pessac, Not set
CH LYON SUD - Hematology, Pierre Benite, Not set
CHU de Tours, Tours, Not set
Vivantes Klinikum Spandau-Klinik f. Innere Medizin Hämatologie/Onkologie/Gastroenterologie - Germany, Berlin, Not set
Universitätsklinikum Carl Gustav Carus; Med. Klinik und Poliklinik I - Hämatologische Ambulanz, Haus, Dresden, Not set
Universitätsklinikum Essen; Klinik f. Hämatologie- Germany, Essen, Not set
Justus-Liebig-Universitaet - Medizinische Klinik IV, Haematologie, Gießen, Not set
Universitätsklinikum Heidelberg Med. Klinik IV, Heidelberg, Not set
Universitätsklinikum des Saarlandes, Homburg/Saar, Not set
Gemeinschaftspraxis Dres. Uhle/Müller/Kröning/Jentsch-Ullrich - Germany, Magdeburg, Not set
OnkoNet Marburg GmbH, Marburg, Not set
Universitätsklinikum für Innere Med. III_Hämatologie, Onkologie...- Germany, Ulm, Not set
Laiko General Hospital - 1st department of Internal Medicine, Athens, Not set
G Papanikolaou Hospital of Thessaloniki, Thessalonikis, Not set
Semmelweis Egyetem, I. Belgyogyaszati Klinika, Budapest N/a, Not set
Szegedi Tudomanyegyetem II. Belgyogyaszati Klinika, Szeged, Not set
St James's Hospital, Dublin, Not set
Haemek Medical Center, Afula, Not set
Hillel Yaffe Medical Center - Oncology, Hadera, Not set
Rambam Health Care Campus, Haifa, Not set
Rabin Medical Center Beilinson Campus, Petah Tikva, Not set
Sheba Medical Center, Ramat-Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
ASST Grande Ospedale Metropolitano Niguarda, Milano, Not set
DIPARTIMENTO DI BIOTECNOLOGIE CELLULARI ED EMATOLOGIA - UNIVERSITà ''LA SAPIENZA'', Roma, Not set
A.O.Citta della Salute e della Scienza di Torino, Torino, Not set
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo ku, Not set
Hiroshima University Hospital, Hiroshima shi, Not set
Hokkaido University Hospital, Sapporo-shi, Not set
National Cancer Center, Goyang-Si, Not set
The Catholic University of Korea Seoul St Mary s Hospital, Seoul, Not set
Oaxaca Site Management Organization S.C., Oaxaca, Not set
VU medisch centrum - Afd.Interne - INT, Amsterdam, Not set
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozow, Not set
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich, Chorzow, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Pratia MCM Krakow, Krakow, Not set
Oddzial Hematologii, Opole, Not set
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka, Slupsk, Not set
Katedra I Klinika Hematologii Nowotworow Krwi I Transplantacji Szpiku, Wroclaw, Not set
Instituto Portugues de Oncologia, Lisboa, Not set
Hospital De Santa Maria, Lisbon, Not set
Instituto Portugues de Oncologia, Porto, Not set
Auxilio Mutuo Cancer Center, San Juan, Not set
Arkhangelsk Regional Clinical Hospital, Arkhangelsk, Not set
Chelyabinsk Regiona Onc. Center, Chelyabinsk, Not set
Emergency Hospital of Dzerzhinsk, Dzerzhinsk, Not set
Cancer Research Center, Moscow N/a, Not set
S.P. Botkin Moscow City Clinical Hospital, Moscow, Not set
Regional Clinical Hospital n.a.Semashko, Nizhni Novgorod, Not set
Medical Scientific Radiology - Center, Obninsk, Not set
Perm Medical Sanitary Unit#1, Perm, Not set
Republican Hospital named by V.A.Baranova, Petrozavodsk, Not set
Rostov Research Institute of Oncology, Rostov-Na-Donu, Not set
Ryazan Regional Clinical Hospital, Ryazan, Not set
Leningrad region clinical hospital, Saint, Not set
Samara Region Clinical Hospital, Samara, Not set
Federal Center of Heart, Blood and Endocrinology, Sankt-Peterburg, Not set
Oncological dispensary #2, Sochi, Not set
City Clinical Oncology Dispensary, St. Petersburg, Not set
Clinical Research Institute of Hematology and Transfusiology, St.-Petersburg, Not set
Oncology Dispensary of Komi Republic, Syktyvkar, Not set
Hospital Vall d'Hebron, Barcelona N/a, Not set
Inst. Cat. Doncologia-H Duran I Reynals, L'hospitalet De Llobregat, Not set
Hosp. Univ. de La Princesa, Madrid, Not set
Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set
Hosp. Univ. Infanta Leonor, Madrid, Not set
Fundacion Jimenez Diaz, Madrid, Not set
Clinica Universitaria de Navarra, Pamplona N/a, Not set
Hospital Clinico Universitario Salamanca, Salamanca, Not set
Sahlgrenska University hospital, Hematology Dept, Göteborg, Not set
Skanes universitetssjukhus, Lund, Not set
Karolinska Universitetssjukhuset Solna, Centrum för Hematologi, Stockholm, Stockholm, Not set
Changhua Cristian Hospital, Changhua County, Not set
Ankara University, Ankara, Not set
American Hospital, Istanbul, Not set
Istanbul University, Istanbul, Not set
Dokuz Eylul Universitesi Tip Fakultesi, Izmir, Not set
Erciyes University, Kayseri, Not set
Communal Nonprofit Enterprise 'Cherkasy Regional Oncology Dispensary Of Cherkasy Regional Council', Cherkasy, Not set
Dnepropetrovsk City Clinical Hospital #4, Regional Hematology Center, Dnepropetrovsk, Not set
SI Grigoriev Institute for Medical Radiology National Academy of Medical Science of Ukraine, Kharkiv, Not set
Khmelnitskiy Regional Hospital, Hematology Department, Khmelnitskiy, Not set
State Institution Scientific Center for Radiation Medicine Academy of Medical Sciences of Ukraine, Kiev, Not set
Institute of Blood Pathology and Transfusion Medicine of AMS of Ukraine, Lviv, Not set
Vinnytsya Regional Clinical Hospital named after M.I.Pirogov, Vinnitsa, Not set
University Hospitals Birmingham NHS Trust,, Birmingham, Not set
Royal Bournemouth Hospital, Bournemouth, Not set
Colchester Hospital University NHS, Colchester, Not set
Beatson West Of Scotland Cancer Centre, Glasgow, Not set
St James's Institute of Oncology, Leeds, Not set
Leicester Royal Infirmary - Haematology, Leicester, Not set
St Bartholomew's Hospital - Dept of Haematology, London, Not set
University College London Hospitals NHSFT, London, Not set
Kings College Hospital, London, Not set
Christie Hospital, Manchester, Not set
Nottingham University Hospitals NHS Trust, Nottingham, Not set
Derriford Hospital, Plymouth, Not set
Royal Hallamshire Hospital, Sheffield, Not set
Southampton General Hospital, Southampton, Not set
Royal Marsden Hospital (Sutton), Sutton, Not set
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B-cell Lymphoma, Waldenstrom Macroglobulinemia, Chronic Graft Versus Host Disease
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
Recruiting
The purpose of this study is to assess the safety and tolerability of zilovertamab vedotin as monotherapy and in combination in participants with select B-cell lymphomas including mantle cell lymphoma (MCL), Richter's transformation lymphoma (RTL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). This study will also evaluate zilovertamab vedotin as monotherapy and in combination with respect to objective response rate.
* Cohort A: Participants with relapsed or refractory MCL r... Read More
The purpose of this study is to assess the safety and tolerability of zilovertamab vedotin as monotherapy and in combination in participants with select B-cell lymphomas including mantle cell lymphoma (MCL), Richter's transformation lymphoma (RTL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). This study will also evaluate zilovertamab vedotin as monotherapy and in combination with respect to objective response rate.
* Cohort A: Participants with relapsed or refractory MCL relapsed or refractory disease after at least 2 prior systemic therapies including a Bruton's tyrosine kinase inhibition/inhibitor (BTKi), and post therapy chimeric antigen receptor T (CAR-T) cell therapy or ineligible for CAR-T cell therapy
* Cohort B: Participants with relapsed or refractory RT disease after at least 1 prior systemic therapy
* Cohort C: Participants with relapsed or refractory MCL relapsed or refractory disease after at least 1 prior systemic therapy and no prior exposure to a non-covalent BTKi
* Cohort D: Participants with relapsed or refractory FL and CLL relapsed or refractory disease after at least 2 prior systemic therapies and have no other available therapy
* Cohort E: Participants with relapsed or refractory FL after at least 2 prior systemic therapies and have no other available therapy
The primary study hypothesis is that zilovertamab vedotin monotherapy has an increased Objective Response Rate (ORR) per Lugano Response Criteria as assessed by blinded independent central review (BICR).
As of Amendment 07, Cohort D is closed to enrollment of participants with CLL and enrollment of participants into Arm 2 (zilovertamab vedotin at Dose 2 on Days 1 \& 8 of each 3 Week Cycle (Q2/3W)). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Alaska Oncology and Hematology ( Site 0037), Anchorage, Alaska +108 locations
Alaska Oncology and Hematology ( Site 0037), Anchorage, Alaska
Banner MD Anderson Cancer Center ( Site 0040), Gilbert, Arizona
Banner MD Anderson Cancer Center - University Medical Center Phoenix-Medical Oncology ( Site 0036), Phoenix, Arizona
University of Colorado Anschutz Medical Campus-The Center for Cancer and Blood Disorders ( Site 0008), Aurora, Colorado
Cancer Care Specialists of Illinois ( Site 0031), Decatur, Illinois
University of Kansas Medical Center-Division of Hematologic Malignancies and Cellular Therapeutics ( Site 0038), Fairway, Kansas
Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0007), Saint Matthews, Kentucky
Greenebaum Comprehensive Cancer Center-Hematology & Multiple Myeloma ( Site 0010), Baltimore, Maryland
Tufts Medical Center ( Site 0024), Boston, Massachusetts
Massachusetts General Hospital ( Site 0018), Boston, Massachusetts
Dana-Farber Cancer Institute-Lymphoma ( Site 0026), Boston, Massachusetts
University of Michigan ( Site 0009), Ann Arbor, Michigan
Henry Ford Hospital ( Site 0035), Detroit, Michigan
Icahn School of Medicine at Mount Sinai ( Site 0023), New York, New York
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0014), Fargo, North Dakota
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0004), Columbus, Ohio
Avera Cancer Institute- Research ( Site 0011), Sioux Falls, South Dakota
Medical Oncology Associates, PS ( Site 0005), Spokane, Washington
University of Wisconsin Hospitals and Clinics-Carbone Cancer Center ( Site 0030), Madison, Wisconsin
MEDICAL COLLEGE OF WISCONSIN ( Site 0021), Milwaukee, Wisconsin
Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 1807), Natal, Rio Grande Do Norte
Instituto Nacional de Câncer - INCA-Divisão de Pesquisa Clínica e Desenvolvimento Tecnológico HC1 ( Site 1809), Rio de Janeiro, Not set
ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 1808), Sao Paulo, Not set
Hospital Paulistano-Americas Oncologia ( Site 1805), Sao Paulo, Not set
BC Cancer Vancouver-Clinical Trials Unit ( Site 0201), Vancouver, British Columbia
The Moncton Hospital-Oncology ( Site 0211), Moncton, New Brunswick
QEII Health Sciences Centre - Victoria General Site ( Site 0213), Halifax, Nova Scotia
Lawson Health Research Institute - London Health Sciences Ce-London Regional Cancer Program ( Site 0203), London, Ontario
Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0200), Toronto, Ontario
Jewish General Hospital ( Site 0202), Montreal, Quebec
Allan Blair Cancer Centre-Care Services ( Site 0208), Regina, Saskatchewan
IC La Serena Research ( Site 1909), La Serena., Coquimbo
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 1907), Santiago., Region M. De Santiago
Clínica Inmunocel ( Site 1910), Santiago, Region M. De Santiago
Clínica Alemana de Santiago ( Site 1903), Santiago, Region M. De Santiago
Beijing Cancer hospital ( Site 1200), Beijing, Beijing
Zhujiang Hospital ( Site 1207), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital ( Site 1202), Guangzhou, Guangdong
Sun Yat-sen University Cancer Center ( Site 1201), Guangzhou, Guangdong
Henan Cancer Hospital-hematology department ( Site 1212), Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1210), Wuhan, Hubei
Tongji Hospital Tongji Medical,Science & Technology ( Site 1221), Wuhan, Hubei
The First Affiliated Hospital of Soochow University-hematology department ( Site 1218), Suzhou, Jiangsu
The Affiliated Hospital of Xuzhou Medical College ( Site 1223), Xuzhou, Jiangsu
The First Affiliated Hospital of Nanchang University ( Site 1204), Nanchang, Jiangxi
Jiangxi Provincial Cancer Hospital ( Site 1213), Nanchang, Jiangxi
Jilin Province Tumor Hospital-oncology department ( Site 1220), Chuangchun, Jilin
Fudan University Shanghai Cancer Center ( Site 1208), Shanghai, Shanghai
West China Hospital of Sichuan University-Head and Neck Oncology ( Site 1206), Cheng Du, Sichuan
The First Affiliated Hospital, Zhejiang University ( Site 1211), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 1214), Hangzhou, Zhejiang
Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0300), Brno, Brno-mesto
Fakultni nemocnice Ostrava-Klinika Hematoonkologie ( Site 0301), Ostrava, Moravskoslezsky Kraj
Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302), Praha 2, Not set
North Estonia Medical Centre Foundation ( Site 0401), Tallinn, Harjumaa
Universitaetsklinikum Ulm. ( Site 0502), Ulm, Baden-Wurttemberg
Universitaetsklinikum Koeln ( Site 0506), Köln, Nordrhein-Westfalen
St. James's Hospital ( Site 0600), Dublin, Not set
Emek Medical Center-Hematology Unit ( Site 0705), Afula, Not set
Soroka Medical Center-Hematology Department ( Site 0707), Be'er Sheva, Not set
Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 0706), Haifa, Not set
Carmel Hospital ( Site 0709), Haifa, Not set
Hadassah Medical Center ( Site 0701), Jerusalem, Not set
Galilee Medical Center ( Site 0710), Nahariya, Not set
Sheba Medical Center-Hemato Oncology ( Site 0700), Ramat Gan, Not set
IRCCS - AOU di Bologna-SSD: Diagnosi e terapie dei linfomi e delle sindromi linfoproliferative cron ( Site 0800), Bologna, Emilia-Romagna
Humanitas-U.O di Oncologia medica ed Ematologia ( Site 0802), Rozzano, Milano
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare -Azienda Ospedaliera Nazionale SS. Ant ( Site 0803), Alessandria, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -ISTITUTO DI EMATOLOGIA ( Site 0804), Roma, Not set
National Hospital Organization Nagoya Medical Center ( Site 1108), Nagoya, Aichi
Hokkaido University Hospital ( Site 1104), Sapporo, Hokkaido
Tokai University Hospital ( Site 1100), Isehara, Kanagawa
Tohoku University Hospital ( Site 1106), Sendai-shi, Miyagi
Kindai University Hospital ( Site 1102), Sayama, Osaka
National Cancer Center Hospital ( Site 1103), Chuo-ku, Tokyo
Cancer Institute Hospital of JFCR ( Site 1101), Koto, Tokyo
Kyushu University Hospital ( Site 1105), Fukuoka, Not set
Okayama University Hospital ( Site 1107), Okayama, Not set
Seoul National University Hospital ( Site 1300), Seoul, Not set
Samsung Medical Center ( Site 1301), Seoul, Not set
Centro Medico Monte Carmelo ( Site 1702), Arequipa, Ariqipa
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 1700), Lima, Not set
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumat-Oddiał Hematologii Ogólnej ( Site 1008), Łódź, Lodzkie
Centrum Onkologii Ziemi Lubelskiej-Oddzial Hematologiczny ( Site 1006), Lublin, Lubelskie
Pratia MCM Krakow ( Site 1001), Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( Site 1002), Warszawa, Mazowieckie
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Hematologii i Transplantacji S ( Site 1010), Kielce, Swietokrzyskie
Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Site 1007), Olsztyn, Warminsko-mazurskie
Champalimaud Foundation ( Site 2002), Lisbon, Lisboa
Unidade Local de Saude de Braga - Hospital de Braga ( Site 2001), Braga, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2000), Porto, Not set
National Cancer Centre Singapore ( Site 1500), Singapore, Central Singapore
Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 4003), L'Hospitalet Del Llobregat, Barcelona
Hospital Universitari Vall d'Hebron ( Site 4004), Barcelona, Cataluna
MD Anderson Cancer Center ( Site 4006), Madrid, Madrid, Comunidad De
Clinica Universidad de Navarra ( Site 4005), Pamplona, Navarra
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca-Hematology ( Site 4001), Salamanca, Not set
Skånes Universitetssjukhus Lund ( Site 5000), Lund, Skane Lan
Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 5002), Uppsala, Uppsala Lan
Sahlgrenska Universitetssjukhuset ( Site 5003), Gothenburg, Vastra Gotalands Lan
Mega Medipol-Hematology ( Site 6009), Stanbul, Istanbul
Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 6001), Ankara, Not set
Trakya University ( Site 6005), Edirne, Not set
Ege Universitesi Hastanesi ( Site 6002), İzmir, Not set
Ondokuz Mayıs Universitesi-Oncology department ( Site 6004), Samsun, Not set
The Royal Cornwall Hospital-Haematology ( Site 7006), Truro, Cornwall
University College London Hospital ( Site 7001), London, London, City Of
The Churchill Hospital ( Site 7002), Oxford, Oxfordshire
The Christie NHS Foundation Trust ( Site 7007), Manchester, Not set
Conditions: Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma
CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies
Recruiting
The investigators propose an early phase study defined as a phase I/II trial assessing safety, feasibility and efficacy of CLIC-1901 autologous anti-CD19 Chimeric Antigen Receptor T cells (CAR-T) cells for participants with relapsed/refractory CD19 positive (CD19+) Acute Lymphoblastic Leukemia (ALL) and non-Hodgkin's Lymphoma (NHL). The Initial Stage of the study (n=20 participants) will focus on feasibility and safety while the Extended Stage will include all participants enrolled in the study... Read More
The investigators propose an early phase study defined as a phase I/II trial assessing safety, feasibility and efficacy of CLIC-1901 autologous anti-CD19 Chimeric Antigen Receptor T cells (CAR-T) cells for participants with relapsed/refractory CD19 positive (CD19+) Acute Lymphoblastic Leukemia (ALL) and non-Hodgkin's Lymphoma (NHL). The Initial Stage of the study (n=20 participants) will focus on feasibility and safety while the Extended Stage will include all participants enrolled in the study (n=additional 80 participants for a total of 100) and will focus on efficacy and safety outcomes. In the proposed trial, we will administer our CAR-T cell product to these participants as a single infusion. Participants will undergo (a) lymphodepletion with cyclophosphamide and fludarabine, followed by (b) infusion of autologous CLIC-1901 CAR-T cells. All treatments will be delivered intravenously. Read Less
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/13/2025
Locations: Vancouver General Hospital, Vancouver, British Columbia +2 locations
Vancouver General Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
The Ottawa Hospital - General Campus, Ottawa, Ontario
Conditions: Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia
A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-319 Moves Through the Bodies of Adult Participants With Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), or Chronic Lymphocytic Leukemia (CLL)
Recruiting
B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). Follicular Lymphoma is a slow-growing type of non-Hodgkin lymphoma. Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of ABBV-319 in adult participants in relapsed or refractory (R/R) diffuse large b-cell lymphoma (DLBCL)... Read More
B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). Follicular Lymphoma is a slow-growing type of non-Hodgkin lymphoma. Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of ABBV-319 in adult participants in relapsed or refractory (R/R) diffuse large b-cell lymphoma (DLBCL), R/R follicular lymphoma (FL), or R/R CLL. Adverse events will be assessed.
ABBV-319 is an investigational drug being developed for the treatment of R/R DLBCL, R/R FL, or R/R CLL. This study will include a dose escalation phase to determine the doses of ABBV-319 that will be used in the next phase and a dose expansion phase to determine the change in disease activity in participants with R/R DLBCL, R/R FL, and R/R CLL. Approximately 154 adult participants with R/R B cell lymphomas including R/R DLBCL, R/R FL, and R/R CLL will be enrolled in the study in sites world wide.
In the Dose Escalation phase of the study participants will receive escalating intravenously infused doses of ABBV-319 in 21-day cycles, until the Phase 2 dose is determined. In the dose expansion phase of the study participants receive intravenously infused ABBV-319 in 21-day cycles.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: University of Arizona Cancer Center - Tucson /ID# 247752, Tucson, Arizona +17 locations
University of Arizona Cancer Center - Tucson /ID# 247752, Tucson, Arizona
Sylvester Comprehensive Cancer Center - University of Miami /ID# 247232, Miami, Florida
Allina Health System /ID# 251782, Minneapolis, Minnesota
University of Nebraska Medical Center /ID# 246715, Omaha, Nebraska
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 249246, New York, New York
Novant Health Presbyterian Medical Center /ID# 246719, Charlotte, North Carolina
Baylor Sammons Cancer Center /ID# 247715, Dallas, Texas
University of Texas Health San Antonio MD Anderson Cancer Center /ID# 256234, San Antonio, Texas
Concord Repatriation General Hospital /ID# 249240, Concord, New South Wales
St Vincent's Hospital Melbourne /ID# 247624, Fitzroy Melbourne, Victoria
One Clinical Research Pty Ltd /ID# 248392, Nedlands, Western Australia
Cross Cancer Institute /ID# 246717, Edmonton, Alberta
University Health Network_Princess Margaret Cancer Centre /ID# 243936, Toronto, Ontario
The Chaim Sheba Medical Center /ID# 254884, Ramat Gan, Tel-Aviv
Hadassah Medical Center-Hebrew University /ID# 254885, Jerusalem, Not set
Seoul National University Hospital /ID# 263945, Seoul, Seoul Teugbyeolsi
Asan Medical Center /ID# 263220, Seoul, Seoul Teugbyeolsi
Samsung Medical Center /ID# 263294, Seoul, Seoul Teugbyeolsi
Conditions: Diffuse Large B-Cell Lymphoma, Chronic Lymphocytic Leukemia, Follicular Lymphoma
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Recruiting
The goal of this study is to evaluate nemtabrutinib compared with investigator's choice of ibrutinib or acalabrutinib in participants with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who have not received any prior therapy. The primary hypotheses are that (1) nemtabrutinib is non-inferior to ibrutinib or acalabrutinib with respect to objective response rate (ORR) per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Criteria 2018 by blinded independent centra... Read More
The goal of this study is to evaluate nemtabrutinib compared with investigator's choice of ibrutinib or acalabrutinib in participants with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who have not received any prior therapy. The primary hypotheses are that (1) nemtabrutinib is non-inferior to ibrutinib or acalabrutinib with respect to objective response rate (ORR) per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Criteria 2018 by blinded independent central review (BICR) and (2) nemtabrutinib is superior to ibrutinib or acalabrutinib with respect to progression free survival (PFS) per iwCLL Criteria 2018 by BICR. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: USA Mitchell Cancer Institute ( Site 0014), Mobile, Alabama +182 locations
USA Mitchell Cancer Institute ( Site 0014), Mobile, Alabama
Arizona Oncology Associates - NAHOA ( Site 8007), Prescott, Arizona
Alta Bates Summit Medical Center ( Site 0004), Berkeley, California
Moores Cancer Center ( Site 0003), La Jolla, California
Saint Joseph Hospital ( Site 0026), Denver, Colorado
Lutheran Medical Center ( Site 0027), Golden, Colorado
Intermountain Health St. Mary's Regional Hospital ( Site 0025), Grand Junction, Colorado
Eastern CT Hematology & Oncology Associates ( Site 0033), Norwich, Connecticut
Clermont Oncology Center ( Site 0046), Clermont, Florida
Florida Cancer Specialists - South ( Site 7001), Fort Myers, Florida
Florida Cancer Specialists - East ( Site 7002), West Palm Beach, Florida
Parkview Research Center at Parkview Regional Medical Center ( Site 0002), Fort Wayne, Indiana
University of Iowa-Holden Comprehensive Cancer Center ( Site 0017), Iowa City, Iowa
Saint Elizabeth Healthcare ( Site 0041), Edgewood, Kentucky
Corewell Health-Lemmon Holton Cancer Pavilion ( Site 0011), Grand Rapids, Michigan
Regions Hospital ( Site 0042), Saint Louis Park, Minnesota
MidAmerica Cancer Care, LLC ( Site 0043), Kansas City, Missouri
Summit Medical Group Cancer Center ( Site 0007), Florham Park, New Jersey
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0016), Hackensack, New Jersey
Roswell Park Cancer Institute ( Site 0023), Buffalo, New York
Consultants in Medical Oncology and Hematology (CMOH) ( Site 8002), Broomall, Pennsylvania
Cancer Care Associates Of York ( Site 0005), York, Pennsylvania
Tennessee Oncology-Chattanooga ( Site 0045), Chattanooga, Tennessee
TENNESSEE ONCOLOGY ( Site 0031), Nashville, Tennessee
Texas Oncology - Central/South Texas ( Site 8008), Austin, Texas
The Center for Cancer and Blood Disorders ( Site 0032), Fort Worth, Texas
Texas Oncology - San Antonio ( Site 8006), San Antonio, Texas
Texas Oncology - Northeast Texas ( Site 8012), Tyler, Texas
University of Virginia Cancer Center ( Site 0040), Charlottesville, Virginia
Inova Schar Cancer Institute ( Site 0015), Fairfax, Virginia
Virginia Commonwealth University (VCU) Medical Center ( Site 0030), Richmond, Virginia
Medical Oncology Associates, PS (dba Summit Cancer Centers) ( Site 0010), Spokane, Washington
University Hospital and UW Health Clinics ( Site 0006), Madison, Wisconsin
Royal North Shore Hospital ( Site 2806), St Leonards, New South Wales
AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0205), Mechelen, Antwerpen
UZ Leuven-Hematology ( Site 0200), Leuven, Vlaams-Brabant
Hospital 9 De Julho ( Site 2206), São Paulo, Sao Paulo
Instituto Nacional de Câncer - INCA ( Site 2201), Rio de Janeiro, Not set
Hospital Paulistano-Americas Oncologia ( Site 2202), Sao Paulo, Not set
BC Cancer Kelowna ( Site 0112), Kelowna, British Columbia
BC Cancer Victoria ( Site 0109), Victoria, British Columbia
William Osler Health System ( Site 0103), Brampton, Ontario
The Ottawa Hospital - General Campus ( Site 0102), Ottawa, Ontario
McGill University Health Centre ( Site 0106), Montréal, Quebec
Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski ( Site 0100), Rimouski, Quebec
Bradfordhill-Clinical Area ( Site 2310), Santiago., Region M. De Santiago
FALP-UIDO ( Site 2300), Santiago, Region M. De Santiago
Clínica Alemana de Santiago-Unidad de Investigaciones ( Site 2306), Santiago, Region M. De Santiago
Anhui Provincial Cancer Hospital ( Site 2001), Hefei, Anhui
Peking University First Hospital ( Site 2022), Beijing, Beijing
Peking University Third Hospital-Hematology ( Site 2011), Beijing, Beijing
Chongqing University Cancer Hospital ( Site 2041), Chongqing, Chongqing
Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 2006), Guangzhou, Guangdong
Sun Yat-sen University Cancer Center ( Site 2028), Guangzhou, Guangdong
Liuzhou People's Hospital ( Site 2029), Liuzhou, Guangxi
Guangxi Medical University Affiliated Tumor Hospital ( Site 2004), Nanning, Guangxi
The Affiliated Hospital of Guizhou Medical University ( Site 2024), Guiyang, Guizhou
Hainan General Hospital ( Site 2018), Haikou, Hainan
Wuhan Union Hospital ( Site 2015), Wuhan, Hebei
Henan Cancer Hospital-hematology department ( Site 2025), Zhengzhou, Henan
Tongji Hospital Affiliated to Tongji Medical College of HUST ( Site 2016), Wuhan, Hubei
Hunan Cancer Hospital ( Site 2020), Changsha, Hunan
The Second Xiangya Hospital of Central South University ( Site 2010), Changsha, Hunan
Jiangsu Province Hospital ( Site 2000), Nanjing, Jiangsu
The First Affliated Hospital of Suzhou University ( Site 2027), Suzhou, Jiangsu
The Affiliated Hospital of Xuzhou Medical College ( Site 2013), Xuzhou, Jiangsu
The First Affiliated Hospital of Nanchang University ( Site 2023), Nanchang, Jiangxi
Jiangxi Provincial Cancer Hospital ( Site 2009), Nanchang, Jiangxi
The First Hospital of Jilin University-Hematology ( Site 2030), Changchun, Jilin
Shaanxi provincial people's hospital ( Site 2012), Xian, Shaanxi
Shandong Cancer Hospital ( Site 2003), Jinan, Shandong
Shanxi Cancer Hospital ( Site 2033), Taiyuan, Shanxi
West China Hospital, Sichuan University-Head and Neck Oncology ( Site 2026), Cheng Du, Sichuan
Tianjin Medical University Cancer Institute & Hospital-lymphoma ( Site 2019), Tianjin, Tianjin
Institute of hematology&blood disease hospital-Lymphoma ( Site 2005), Tianjin, Tianjin
Xinjiang Medical University Cancer Hospital - Urumqi ( Site 2014), Urumqi, Xinjiang
The first Affiliated Hospital, Zhejiang University School of Medicine-Hematology ( Site 2002), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 2017), Hangzhou, Zhejiang
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 2405), Valledupar, Cesar
IMAT S.A.S ( Site 2401), Monteria, Cordoba
Fundacion Valle del Lili- CIC-Oncology CIC ( Site 2402), Cali, Valle Del Cauca
Fakultni nemocnice Hradec Kralove-IV. interni hematologicka klinika ( Site 0301), Hradec Kralove, Not set
Fakultni nemocnice Olomouc ( Site 0303), Olomouc, Not set
Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302), Praha 2, Not set
Aalborg Universitetshospital, Syd ( Site 0403), Aalborg, Nordjylland
Roskilde Sygehus-Department of Hematology ( Site 0402), Roskilde, Sjaelland
Odense Universitetshospital-Department of Hematology ( Site 0401), Odense C, Syddanmark
Universitaetsklinikum Ulm. ( Site 0601), Ulm, Baden-Wurttemberg
VK&K Studien GbR ( Site 0607), Landshut, Bayern
Kliniken Maria Hilf ( Site 0603), Mönchengladbach, Nordrhein-Westfalen
InVO Institut für Versorgungsforschung in der Onkologie ( Site 0606), Koblenz, Rheinland-Pfalz
Universitätsklinikum Halle ( Site 0604), Halle, Sachsen-Anhalt
Onkologische Schwerpunktpraxis Kurfuerstendamm ( Site 0600), Berlin, Not set
University Hospital of Alexandroupolis ( Site 0701), Alexandroupolis, Anatoliki Makedonia Kai Thraki
Evangelismos General Hospital of Athens ( Site 0700), Athens, Attiki
General Hospital of Athens "Laiko" ( Site 0704), Athens, Attiki
University Hospital of Ioannina ( Site 0702), Ioannina, Not set
Queen Mary Hospital ( Site 3300), Hong Kong, Not set
Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 1503), Haifa, Not set
Bnai Zion Medical Center ( Site 1505), Haifa, Not set
Hadassah Medical Center-Hemato-Oncology ( Site 1500), Jerusalem, Not set
Rabin Medical Center ( Site 1504), Petah Tikva, Not set
Sheba Medical Center-Hemato Oncology ( Site 1501), Ramat Gan, Not set
Yitzhak Shamir Medical Center. ( Site 1506), Zerifin, Not set
Nagoya University Hospital ( Site 1907), Nagoya, Aichi
Gunma University Hospital ( Site 1903), Maebashi, Gunma
Hokkaido University Hospital ( Site 1900), Sapporo, Hokkaido
Kobe City Medical Center General Hospital ( Site 1910), Kobe, Hyogo
Tohoku University Hospital ( Site 1901), Sendai, Miyagi
Kindai University Hospital ( Site 1909), Sayama, Osaka
Shimane University Hospital ( Site 1911), Izumo, Shimane
Cancer Institute Hospital of JFCR ( Site 1906), Koto, Tokyo
Chiba Cancer Center ( Site 1905), Chiba, Not set
Kyushu University Hospital ( Site 1914), Fukuoka, Not set
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 1913), Hiroshima, Not set
Okayama University Hospital ( Site 1912), Okayama, Not set
Japanese Red Cross Osaka Hospital ( Site 1908), Osaka, Not set
Yamagata University Hospital ( Site 1902), Yamagata, Not set
University Malaya Medical Centre ( Site 1604), Lembah Pantai, Kuala Lumpur
Hospital Pulau Pinang ( Site 1602), George Town, Pulau Pinang
Queen Elizabeth Hospital ( Site 1603), Kota Kinabalu, Sabah
Centro de Infusion Superare ( Site 2602), Ciudad de México, Distrito Federal
Health Pharma Professional Research S.A. de C.V: ( Site 2608), Ciudad de México, Distrito Federal
Waikato Hospital-Haematology ( Site 3202), Hamilton, Waikato
North Shore Hospital-Department of Haematology ( Site 3200), Auckland, Not set
Aotearoa Clinical Trials ( Site 3201), Auckland, Not set
Akershus Universitetssykehus ( Site 0902), Lørenskog, Akershus
Sykehuset i Vestfold ( Site 0903), Toensberg, Vestfold
Oslo Universitetssykehus Rikshospitalet-Avdeling for blodsykdommer ( Site 0901), Oslo, Not set
Centro Medico Monte Carmelo-Oncology ( Site 2706), Arequipa, Ariqipa
Clínica Anglo Americana ( Site 2701), Lima, Not set
Uniwersytecki Szpital Kliniczny nr 1 w Lublinie-Oddział Hematoonkologii-Transplantacji Szpiku i Chem ( Site 1006), Lublin, Lubelskie
Pratia MCM Krakow ( Site 1007), Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site 1004), Warszawa, Mazowieckie
Uniwersyteckie Centrum Kliniczne-Klinika Hematologii i Transplantologii ( Site 1011), Gdansk, Pomorskie
Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku-Oddział Hematologii i Transplantacji ( Site 1013), Słupsk, Pomorskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1000), Gliwice, Slaskie
Pratia Onkologia Katowice ( Site 1009), Katowice, Slaskie
Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Site 1005), Olsztyn, Warminsko-mazurskie
Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 3103), Lisbon, Lisboa
Champalimaud Foundation ( Site 3102), Lisbon, Lisboa
Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 3107), Vila Nova de Gaia, Porto
Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 3104), Lisboa, Not set
Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 3106), Lisboa, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 3100), Porto, Not set
Netcare Pretoria East Hospital-Alberts Cellular Therapy ( Site 1101), Centurion, Gauteng
Wits Clinical Research ( Site 1102), Johannesburg, Gauteng
Groote Schuur Hospital-Clinical Haematology ( Site 1100), Cape Town, Western Cape
Haemalife ( Site 1105), Kuilsriver, Western Cape
Constantiaberg Haematology ( Site 1106), Plumstead, Western Cape
Institut Català d'Oncologia - L'Hospitalet-Haematology Department ( Site 1207), L'Hospitalet Del Llobregat, Barcelona
HOSPITAL CLÍNIC DE BARCELONA ( Site 1202), Barcelona, Cataluna
HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 1208), Majadahonda, Madrid, Comunidad De
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1209), Pozuelo de Alarcon, Madrid
hospital universitario de canarias ( Site 1205), La Laguna, Santa Cruz De Tenerife
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1206), Barcelona, Not set
Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 1201), Salamanca, Not set
Karolinska Universitetssjukhuset Solna ( Site 1302), Stockholm, Stockholms Lan
Chang Gung Memorial Hospital at Kaohsiung-Division of Hematology and Oncology ( Site 1702), Kaohsiung, Not set
National Cheng Kung University Hospital ( Site 1700), Tainan, Not set
National Taiwan University Hospital ( Site 1701), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch ( Site 1703), Taoyuan, Not set
Maharaj Nakorn Chiang Mai Hospital ( Site 1800), Muang, Chiang Mai
Chulalongkorn University ( Site 1802), Bangkok, Krung Thep Maha Nakhon
Faculty of Medicine Siriraj Hospital-Division of Hematology, Department of Medicine ( Site 1801), Bangkok, Krung Thep Maha Nakhon
Naresuan University Hospital ( Site 1804), Muang, Phitsanulok
Songklanagarind hospital ( Site 1803), HatYai, Songkhla
Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 1401), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1407), Ankara, Not set
Antalya Egitim ve Arastırma Hastanesi ( Site 1409), Antalya, Not set
Trakya University-Balkan Onkoloji Hastanesi ( Site 1403), Edirne, Not set
Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 1408), Istanbul, Not set
Ege Universitesi Hastanesi ( Site 1404), İzmir, Not set
Ondokuz Mays Üniversitesi ( Site 1410), Samsun, Not set
Southmead Hospital ( Site 3010), Bristol, Bristol, City Of
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3006), London, London, City Of
The Churchill Hospital ( Site 3007), Oxford, Oxfordshire
GenesisCare - Bristol ( Site 3011), Bristol, South Gloucestershire
GenesisCare - Cambridge ( Site 3001), Newmarket, Suffolk
GenesisCare - Windsor ( Site 3002), Windsor, Windsor And Maidenhead
Barnet Hospital ( Site 3005), Barnet, Not set
St James's University Hospital ( Site 3004), Leeds, Not set
City Hospital, Nottingham University Hospitals NHS Trust ( Site 3003), Nottingham, Not set
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Recruiting
The main purpose of Part 1 of this study is to assess the efficacy and safety of 3 dose levels of Pirtobrutinib in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), who have received 1-3 lines of treatment including a covalent Bruton tyrosine kinase (BTK) inhibitor. The purpose of Part 2 of this study is to evaluate pirtobrutinib monotherapy in participants with treatment-naïve CLL/SLL with 17p deletions. Participation in Part 1 is expected to last approxi... Read More
The main purpose of Part 1 of this study is to assess the efficacy and safety of 3 dose levels of Pirtobrutinib in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), who have received 1-3 lines of treatment including a covalent Bruton tyrosine kinase (BTK) inhibitor. The purpose of Part 2 of this study is to evaluate pirtobrutinib monotherapy in participants with treatment-naïve CLL/SLL with 17p deletions. Participation in Part 1 is expected to last approximately 3 years. Participation in Part 2 is expected to last up to 2 years. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2025
Locations: Ironwood Cancer & Research Centers, Chandler, Arizona +135 locations
Ironwood Cancer & Research Centers, Chandler, Arizona
City of Hope National Medical Center, Duarte, California
City of Hope National Medical Center, Irvine, California
Palo Alto Medical Foundation Research Institute (PAMFRI), Palo Alto, California
Stanford Cancer Center, Palo Alto, California
Rocky Mountain Cancer Center, Aurora, Colorado
University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami, Florida
City of Hope National Medical Center, Atlanta Cancer Center, Newnan, Georgia
Mission Cancer + Blood, Waukee, Iowa
Saint Elizabeth Medical Center Edgewood, Edgewood, Kentucky
American Oncology Partners of Maryland, PA, Bethesda, Maryland
Boston Medical Center, Boston, Massachusetts
Gulfport Memorial Hospital, Gulfport, Mississippi
Comprehensive Cancer Centers of Nevada, Henderson, Nevada
Clinical Research Alliance, Westbury, New York
East Carolina University, Greenville, North Carolina
Williamette Valley Cancer Institute & Research Center, Eugene, Oregon
Cancer Care Associates Of York, York, Pennsylvania
The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee
USO-Texas Oncology-Central/South Texas, Austin, Texas
Sarah Cannon Research Institute/SCRI, The Woodlands, Texas
USO-Virginia Oncology Associates, Hampton, Virginia
USO-Northwest Cancer Specialists, PC, Vancouver, Washington
Bankstown-Lidcombe Hospital, Bankstown, New South Wales
Coffs Harbour Health Campus, Coffs Harbour, New South Wales
Calvary Mater Newcastle, Waratah, New South Wales
Princess Alexandra Hospital, Woolloongabba, Queensland
Flinders Medical Centre, Adelaide, South Australia
ICON Cancer Centre - Kurralta Park, Kurralta Park, South Australia
Royal Hobart Hospital, Hobart, Tasmania
Box Hill Hospital, Box Hill, Victoria
Latrobe Regional Health, Traralgon, Victoria
The Perth Blood Institute - West Perth, West Perth, Western Australia
Clinique Saint Pierre, Ottignies, Brabant Wallon
Institut Jules Bordet, Anderlecht, Bruxelles-Capitale, Région De
Groupe Jolimont, La Louvière, Hainaut
CHR Verviers - La Tourelle, Verviers, Liège
UZ Gent, Gent, Oost-Vlaanderen
AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen
UZ Leuven, Leuven, Vlaams-Brabant
AZ Sint-Jan Brugge-Oostende AV, Brugge, West-Vlaanderen
AZ Delta vzw, Roeselare, West-Vlaanderen
Royal Victoria Regional Health Centre, Barrie, Ontario
CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Fakultní nemocnice Brno Bohunice, Brno, Brno-město
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové
Fakultni nemocnice Kralovske Vinohrady, PRague, Praha 10
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland
Odense Universitetshospital, Odense, Syddanmark
Centre Antoine-Lacassagne, Nice, Alpes-Maritimes
Groupe Hospitalier de la Région de Mulhouse et Sud Alsace - Hôpital Emile Muller, Mulhouse, Alsace
Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre, Caen, Calvados
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours, Indre-et-Loire
Centre Hospitalier du Mans, Le Mans, Sarthe
Centre Hospitalier d'Argenteuil Victor Dupouy, Argenteuil, Val-d'Oise
Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Bayern
Centrum für Hämatologie und Onkologie Bethanien, Frankfurt, Hessen
OSP Göttingen, Goettingen, Niedersachsen
Onkologisches Ambulanzzentrum Hannover, Hannover, Niedersachsen
MV-Zentrum für Onkologie und Hämatologie, Cologne, Nordrhein-Westfalen
InVO Institut für Versorgungsforschung in der Onkologie, Koblenz, Rheinland-Pfalz
Evangelismos General Hospital of Athens, Athens, Attikí
Attikon General University Hospital, Chaidari, Attikí
General Hospital of Athens "Laiko", Αthens, Attikí
G. Papanikolaou General Hospital, Thessaloniki, Thessaloníki
Pécsi Tudományegyetem Klinikai Központ, Pécs, Baranya
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged, Csongrád
Semmelweis Egyetem, Budapest, Not set
Dél-Pesti Centrumkórház, Budapest, Not set
Azienda Ospedaliero Universitaria S.Anna, Cona, Emilia-Romagna
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma, Lazio
ASST Grande Ospedale Metropolitano Niguarda, Milan, Lombardia
A.O.U.C. Policlinico di Bari, Bari, Puglia
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO, Palermo, Sicilia
Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana
AO Santa Maria della Misericordia, Perugia, Umbria
Azienda Ospedale - Università Padova, Padova, Veneto
Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Not set
AOU Policlinico Umberto I, Roma, Not set
Chonnam National University Hwasun Hospital, Hwasun-gun, Jeonranamdo
Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi
Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wrocław, Dolnośląskie
IN VIVO, Bydgoszcz, Kujawsko-pomorskie
Pratia MCM Krakow, Kraków, Małopolskie
AIDPORT Sp. z o.o., Skórzewo, Wielkopolskie
Pratia Onkologia Katowice, Katowice, Śląskie
Fundeni Clinical Institute, Bucuresti, București
Ovidius Clinical Hospital OCH, Ovidiu, Constanța
Spitalul Clinic Municipal Filantropia Craiova, Craiova, Dolj
Spitalul Clinic Colțea, București, Not set
Institutul Oncologic Cluj, Cluj, Not set
Institutul Regional de Oncologie, Iași, Not set
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banska Bystrica, Banskobystrický Kraj
Narodny onkologicky ustav, Bratislava, Bratislavský Kraj
Univerzitna Nemocnica L. Pasteura Kosice, Kosice, Košický Kraj
Univerzitna nemocnica Martin, Martin, Žilinský Kraj
Hospital Universitario Virgen Macarena, Sevilla, Andalucía
Hospital Universitario Central de Asturias, Oviedo, Asturias
Institut Català d'Oncologia (ICO) - Badalona, Badalona, Barcelona [Barcelona]
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]
Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet Del Llobregat, Barcelona [Barcelona]
Hospital Universitario Marqués de Valdecilla, Santander, Cantabria
Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña]
Clinica Universidad de Navarra, Madrid, Madrid, Comunidad De
Hospital Universitario Infanta Leonor, Madrid, Madrid, Comunidad De
MD Anderson Cancer Center, Madrid, Madrid, Comunidad De
Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Hospital Costa del Sol, Marbella, Málaga
Hospital Universitario Quironsalud Madrid, Madrid, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Kocaeli Üniversitesi, Izmit, Kocaeli
Sakarya University School of Medicine, Adapazarı, Sakarya
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi, Ankara, Not set
Ankara University Health Practice and Research Hospitals, Ankara, Not set
Memorial Antalya Hospital, Antalya, Not set
Yeditepe Üniversitesi Koşuyolu Hastanesi, Istanbul, Not set
Ege Universitesi Hastanesi, Izmir, Not set
VM Medical Park Mersin Hastanesi, Mersin, Not set
Ondokuz Mayıs Universitesi, Samsun, Not set
Maidstone Hospital, Maidstone, Kent
Lincoln County Hospital, Lincoln, Lincolnshire
Northwick Park Hospital, Harrow, London, City Of
Hammersmith Hospital, London, London, City Of
Heartlands Hospital, Birmingham, Not set
The Beatson West of Scotland Cancer Centre, Glasgow, Not set
St James's University Hospital, Leeds, Not set
Clatterbridge Cancer Centre - Liverpool, Liverpool, Not set
Singleton Hospital, Swansea, Not set
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma:
Recruiting
Utilization data will be collected from all patients entered on the trial at Canadian centres from the time of registration until death, removal from study, or completion of 10 years of follow-up.
Protocol-specified health care utilization will be collected within trial case report forms, and will include study visits, radiographic assessments, laboratory investigations, and treatment administration.
Resource utilization data collection will be supplemented by a self-administered resource util... Read More
Utilization data will be collected from all patients entered on the trial at Canadian centres from the time of registration until death, removal from study, or completion of 10 years of follow-up.
Protocol-specified health care utilization will be collected within trial case report forms, and will include study visits, radiographic assessments, laboratory investigations, and treatment administration.
Resource utilization data collection will be supplemented by a self-administered resource utilization form (Stanford SMRC) to document non-protocol specified utilization. This will include hospitalizations (including days in hospital), emergency room visits, and non-protocol specified ambulatory visits. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2025
Locations: BCCA - Vancouver, Vancouver, British Columbia +7 locations
BCCA - Vancouver, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Regional Health Authority B, Zone 2, Saint John, New Brunswick
QEII Health Sciences Centre, Halifax, Nova Scotia
Lakeridge Health Oshawa, Oshawa, Ontario
Ottawa Hospital Research Institute, Ottawa, Ontario
The Jewish General Hospital, Montreal, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
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