Coronary Artery Disease Clinical Trials in Canada

A listing of 19 Coronary Artery Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 19 active clinical trials seeking participants for Coronary Artery Disease research studies. The states with the highest number of trials for Coronary Artery Disease participants are .

Product Surveillance Registry

NCT01524276

Recruiting

The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products. The Registry data is intended to benefit and support interests of patients, hospitals, clinicians, regulatory bodies, payers, and industry by streamlining the clinical surveillance process and facilitating leading edge performance assessment via the least burdensome approach.

Gender:

ALL

Ages:

All

Trial Updated:

07/24/2025

Locations: Not set, Birmingham, Alabama +381 locations

Not set, Birmingham, Alabama

Not set, Huntsville, Alabama

Not set, Chandler, Arizona

Not set, Phoenix, Arizona

Not set, Little Rock, Arkansas

Not set, Aliso Viejo, California

Not set, Chula Vista, California

Not set, Colton, California

Not set, La Jolla, California

Not set, Los Angeles, California

Not set, Napa, California

Not set, Redwood City, California

Not set, Salinas, California

Not set, San Diego, California

Not set, Stanford, California

Not set, Torrance, California

Not set, Ventura, California

Not set, Aurora, Colorado

Not set, Colorado Springs, Colorado

Not set, Lakewood, Colorado

Not set, Darien, Connecticut

Not set, Hartford, Connecticut

Not set, New Haven, Connecticut

Not set, Washington, District of Columbia

Not set, Bradenton, Florida

Not set, Clearwater, Florida

Not set, Davie, Florida

Not set, Jacksonville, Florida

Not set, Naples, Florida

Not set, Panama City, Florida

Not set, Safety Harbor, Florida

Not set, Sarasota, Florida

Not set, Weston, Florida

Not set, Gainesville, Georgia

Not set, Chicago, Illinois

Not set, Evansville, Indiana

Not set, Indianapolis, Indiana

Not set, Iowa City, Iowa

Not set, West Des Moines, Iowa

Not set, Kansas City, Kansas

Not set, Edgewood, Kentucky

Not set, Louisville, Kentucky

Not set, New Orleans, Louisiana

Not set, Hyattsville, Maryland

Not set, Salisbury, Maryland

Not set, Silver Spring, Maryland

Not set, Boston, Massachusetts

Not set, Holyoke, Massachusetts

Not set, Ann Arbor, Michigan

Not set, Bay City, Michigan

Not set, Lansing, Michigan

Not set, Rochester Hills, Michigan

Not set, Ypsilanti, Michigan

Not set, Coon Rapids, Minnesota

Not set, Minneapolis, Minnesota

Not set, Robbinsdale, Minnesota

Not set, Rochester, Minnesota

Not set, Saint Cloud, Minnesota

Not set, Jackson, Mississippi

Not set, Columbia, Missouri

Not set, Kansas City, Missouri

Not set, St. Louis, Missouri

Not set, Omaha, Nebraska

Not set, Lebanon, New Hampshire

Not set, Camden, New Jersey

Not set, Marlton, New Jersey

Not set, Morristown, New Jersey

Not set, Ocean Township, New Jersey

Not set, Teaneck, New Jersey

Not set, Albuquerque, New Mexico

Not set, Albany, New York

Not set, Bay Shore, New York

Not set, Huntington, New York

Not set, Manhasset, New York

Not set, Mount Kisco, New York

Not set, New Hyde Park, New York

Not set, New York, New York

Not set, Poughkeepsie, New York

Not set, Riverhead, New York

Not set, Roslyn, New York

Not set, Staten Island, New York

Not set, Stony Brook, New York

Not set, Utica, New York

Not set, Chapel Hill, North Carolina

Not set, Charleston, North Carolina

Not set, Durham, North Carolina

Not set, Pinehurst, North Carolina

Not set, Raleigh, North Carolina

Not set, Winston Salem, North Carolina

Not set, Cleveland, Ohio

Not set, Columbus, Ohio

Not set, Dayton, Ohio

Not set, Mount Orab, Ohio

Not set, Portland, Oregon

Not set, Allentown, Pennsylvania

Not set, Bethlehem, Pennsylvania

Not set, Danville, Pennsylvania

Not set, Erie, Pennsylvania

Not set, Lancaster, Pennsylvania

Not set, Mechanicsburg, Pennsylvania

Not set, Pittsburgh, Pennsylvania

Not set, Wilkes-Barre, Pennsylvania

Not set, Charleston, South Carolina

Not set, Columbia, South Carolina

Not set, Orangeburg, South Carolina

Not set, Spartanburg, South Carolina

Not set, Sioux Falls, South Dakota

Not set, Germantown, Tennessee

Not set, Memphis, Tennessee

Not set, Nashville, Tennessee

Not set, Austin, Texas

Not set, Dallas, Texas

Not set, Ft. Worth, Texas

Not set, Houston, Texas

Not set, Kyle, Texas

Not set, Plano, Texas

Not set, San Antonio, Texas

Not set, Tyler, Texas

Not set, Salt Lake City, Utah

Not set, Burlington, Vermont

Not set, Charlottesville, Virginia

Not set, Fairfax, Virginia

Not set, Fredericksburg, Virginia

Not set, Bremerton, Washington

Not set, Seattle, Washington

Not set, Spokane, Washington

Not set, Morgantown, West Virginia

Not set, Madison, Wisconsin

Not set, Milwaukee, Wisconsin

Not set, Buenos Aires, Not set

Not set, Westmead, New South Wales

Not set, Chermside, Not set

Not set, Murdoch, Not set

Not set, Southport, Not set

Not set, Innsbruck, Not set

Not set, Linz, Not set

Not set, Aalst, Not set

Not set, Brugge, Not set

Not set, Brussel, Not set

Not set, Edegem, Not set

Not set, Genk, Not set

Not set, Gent, Not set

Not set, Leuven, Not set

Not set, Liege, Not set

Not set, Roeselare, Not set

Not set, Sint-Niklaas, Not set

Not set, São Paulo, Not set

Not set, Calgary, Alberta

Not set, Kingston, Ontario

Not set, Montreal, Quebec

Not set, Quebec City, Not set

Not set, Quebec, Not set

Not set, Toronto, Not set

Not set, Chengdu, Sichuan

Not set, Beijing, Not set

Not set, Chengdu, Not set

Not set, Dalian, Not set

Not set, Guangzhou, Not set

Not set, Hangzhou, Not set

Not set, Harbin, Not set

Not set, Kunming, Not set

Not set, Nanchang, Not set

Not set, Shanghai, Not set

Not set, Suzhou, Not set

Not set, Medellin, Not set

Not set, Pereira, Not set

Not set, Rionegro, Not set

Not set, Praha, Not set

Not set, Hellerup, Not set

Not set, Hillerød, Not set

Not set, Kobenhavn, Not set

Not set, Odense, Not set

Not set, Helsinki, Not set

Not set, Tampere, Not set

Not set, Avignon, Not set

Not set, Bordeaux, Not set

Not set, Boulogne-Billancourt, Not set

Not set, Brest Cedex, Not set

Not set, Caen, Not set

Not set, Chambray, Not set

Not set, Clermont Ferrand, Not set

Not set, Créteil, Not set

Not set, Dijon, Not set

Not set, La Rochelle, Not set

Not set, La Tronche, Not set

Not set, Lille Cedex, Not set

Not set, Marseille Cedex 5, Not set

Not set, Montpellier Cedex 5, Not set

Not set, Nantes, Not set

Not set, Ollioules, Not set

Not set, Paris, Not set

Not set, Pessac, Not set

Not set, Pringy, Not set

Not set, Rennes, Not set

Not set, Saint-Priest-en-Jarez, Not set

Not set, Strasbourg, Not set

Not set, Toulouse Cedex 9, Not set

Not set, Villeurbanne, Not set

Not set, Aachen, Not set

Not set, Arnsberg, Not set

Not set, Bad Oeynhausen, Not set

Not set, Berlin, Not set

Not set, Bochum, Not set

Not set, Bremen, Not set

Not set, Düsseldorf, Not set

Not set, Freiburg, Not set

Not set, Hagen, Not set

Not set, Halle (Saale), Not set

Not set, Hamburg, Not set

Not set, Hannover, Not set

Not set, Heidelberg, Not set

Not set, Jena, Not set

Not set, Karlsruhe, Not set

Not set, Köln, Not set

Not set, Leipzig, Not set

Not set, Lübeck, Not set

Not set, Munster, Not set

Not set, München, Not set

Not set, Stuttgart, Not set

Not set, Tubingen, Not set

Not set, Ulm, Not set

Not set, Wiesbaden, Not set

Not set, Athens, Not set

Not set, Maroúsi, Not set

Not set, Thessaloníki, Not set

Not set, Hong Kong, Not set

Not set, Budapest, Not set

Not set, Hyderabad, Telangana

Not set, Bangalore, Not set

Not set, Bengaluru, Not set

Not set, Chennai, Not set

Not set, Gurugram, Not set

Not set, New Delhi, Not set

Not set, Galway, Not set

Not set, Ashkelon, Not set

Not set, Be'er Sheva, Not set

Not set, Jerusalem, Not set

Not set, Ramat Gan, Not set

Not set, Acquaviva Delle Fonti, Not set

Not set, Ancona, Not set

Not set, Bari, Not set

Not set, Bologna, Not set

Not set, Brescia, Not set

Not set, Caserta, Not set

Not set, Castrovillari, Not set

Not set, Cotignola, Not set

Not set, Lecce, Not set

Not set, Milano, Not set

Not set, Modena, Not set

Not set, Monza, Not set

Not set, Palermo, Not set

Not set, Pisa, Not set

Not set, Roma, Not set

Not set, Rome, Not set

Not set, Taranto, Not set

Not set, Udine, Not set

Not set, Sakai, Osaka

Not set, Ageo, Saitama

Not set, Hidaka, Saitama

Not set, Koshigaya, Saitama

Not set, Tokyo, Tachikawa

Not set, Bunkyō-Ku, Tokyo

Not set, Minato-Ku, Tokyo

Not set, Yonago, Tottori

Not set, Chiba, Not set

Not set, Fukui, Not set

Not set, Fukuoka, Not set

Not set, Gifu, Not set

Not set, Hirosaki, Not set

Not set, Hiroshima City, Not set

Not set, Hiroshima, Not set

Not set, Kagoshima, Not set

Not set, Kamakura, Not set

Not set, Kawasaki, Not set

Not set, Kitakyushu, Not set

Not set, Kofu, Not set

Not set, Kumamoto, Not set

Not set, Kyoto, Not set

Not set, Mitaka, Not set

Not set, Nagoya, Not set

Not set, Niigata, Not set

Not set, Okayama, Not set

Not set, Sapporo, Not set

Not set, Shinagawa-Ku, Not set

Not set, Shizuoka, Not set

Not set, Suita, Not set

Not set, Tokyo, Not set

Not set, Toyoake, Not set

Not set, Urasoe, Not set

Not set, Yokohama, Not set

Not set, Ōsaka-sayama, Not set

Not set, Yangsan, Gyeongsangnam-do

Not set, Busan, Not set

Not set, Changwon, Not set

Not set, Cheongju-si, Not set

Not set, Daegu, Not set

Not set, Daejeon, Not set

Not set, Gangneung, Not set

Not set, Gwangju, Not set

Not set, Gyeonggi-do, Not set

Not set, Incheon, Not set

Not set, Jeonju, Not set

Not set, Seongnam-si, Not set

Not set, Seoul, Not set

Not set, Suwon-si, Not set

Not set, Kuwait, Not set

Not set, Kuala Lumpur, Not set

Not set, Ciudad de mexico, Not set

Not set, Den Haag, Not set

Not set, Doetinchem, Not set

Not set, Eindhoven, Not set

Not set, Enschede, Not set

Not set, Groningen, Not set

Not set, Heerlen, Not set

Not set, Hengelo, Not set

Not set, Leiden, Not set

Not set, Maastricht, Not set

Not set, Nieuwegein, Not set

Not set, Rotterdam, Not set

Not set, Christchurch, Not set

Not set, Bergen, Not set

Not set, Lorenskog, Not set

Not set, Trondheim, Not set

Not set, Panama, Not set

Not set, Poznań, Not set

Not set, Warszawa, Not set

Not set, Zabrze, Not set

Not set, Carnaxide, Not set

Not set, Creixomil, Not set

Not set, Lisboa, Not set

Not set, Porto, Not set

Not set, Santarém, Not set

Not set, Aibonito, Not set

Not set, Rio Piedras, Not set

Not set, Jeddah, Not set

Not set, Riyadh, Not set

Not set, Belgrade, Not set

Not set, Bratislava, Not set

Not set, A Coruña, Not set

Not set, Barcelona, Not set

Not set, Córdoba, Not set

Not set, Elche, Not set

Not set, Girona, Not set

Not set, Granada, Not set

Not set, L'Hospitalet De Llobregat, Not set

Not set, Madrid, Not set

Not set, Málaga, Not set

Not set, Palma De Mallorca, Not set

Not set, Salamanca, Not set

Not set, Santa Cruz De Tenerife, Not set

Not set, Santiago De Compostela, Not set

Not set, Toledo, Not set

Not set, Valencia, Not set

Not set, Valladolid, Not set

Not set, Vitoria-Gasteiz, Not set

Not set, Skövde, Not set

Not set, Basel, Not set

Not set, Bern, Not set

Not set, Fribourg, Not set

Not set, Geneve, Not set

Not set, Lausanne, Not set

Not set, Lugano, Not set

Not set, Morges, Not set

Not set, Zürich, Not set

Not set, Taichung, Not set

Not set, Barnstaple, Not set

Not set, Birmingham, Not set

Not set, Blackpool, Not set

Not set, Bristol, Not set

Not set, Chelmsford, Not set

Not set, Glasgow, Not set

Not set, Harrow, Not set

Not set, Leeds, Not set

Not set, Leicester, Not set

Not set, Liverpool, Not set

Not set, London, Not set

Not set, Manchester, Not set

Not set, Middlesbrough, Not set

Not set, Newcastle Upon Tyne, Not set

Not set, Northampton, Not set

Not set, Sheffield, Not set

Not set, Southampton, Not set

Conditions: Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders, Digestive Disorders, Intracranial Aneurysm, Mechanical Circulatory Support, Respiratory Therapy, Aortic, Peripheral Vascular and Venous Disorders, Minimally Invasive Surgical Procedures, Diagnostic Techniques and Procedures, Surgical Procedures, Operative, Renal Insufficiency, Neurovascular, Coronary Artery Disease, Ear, Nose and Throat Disorder

Learn More ›

Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

NCT04634240

Recruiting

Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis. There is uncertainty about the benefits and the optimal timing of revascularization for such patients. There is currently clinical equipoise regarding the management of concomitant CAD in patients undergoing TAVR. Some centers perform routine revascularization with percutaneous coronary intervention (PCI) (either before or after TAVR), while others follow an alternative strategy of medical management. The potential benefits and optimal timing of PCI in these patients are unknown. As TAVR expands to lower risk patients, and potentially becomes the preferred therapy for the majority of patients with severe aortic stenosis, the optimal management of concomitant coronary artery disease will be of increasing importance. The COMPLETE TAVR study will determine whether, on a background of guideline-directed medical therapy, a strategy of complete revascularization involving staged PCI using drug eluting stents to treat all suitable coronary artery lesions is superior to a strategy of medical therapy alone in reducing the composite outcome of Cardiovascular Death, new Myocardial Infarction, Ischemia-driven Revascularization or Hospitalization for Unstable Angina or Heart Failure. The study will be a randomized, multicenter, open-label trial with blinded adjudication of outcomes. Patients will be screened and consented for elective transfemoral TAVR and randomized within 96 hours of successful balloon expandable TAVR. Complete Revascularization: Staged PCI using third generation drug eluting stents to treat all suitable coronary artery lesions in vessels that are at least 2.5 mm in diameter and that are amenable to treatment with PCI and have a ≥70% visual angiographic diameter stenosis. Staged PCI can occur any time from 1 to 45 days post successful transfemoral TAVR. Vs. Medical Therapy Alone: No further revascularization of coronary artery lesions. All patients, regardless of randomized treatment allocation, will receive guideline-directed medical therapy consisting of risk factor modification and use of evidence-based therapies. The COMPLETE TAVR study will help address the current lack of evidence in this area. It will likely impact both the global delivery of health care and the management and clinical outcomes of all patients undergoing TAVR with concomitant CAD. Read Less

Gender:

ALL

Ages:

All

Trial Updated:

07/22/2025

Locations: Huntsville Heart Center, Huntsville, Alabama +71 locations

Huntsville Heart Center, Huntsville, Alabama

Arizona Cardiovascular Research, Phoenix, Arizona

Veteran Affairs Palo Alto Health Care System, Palo Alto, California

Loma Linda University, Redlands, California

Santa Barbara Cottage Hospital, Santa Barbara, California

Torrance Memorial Medical Center, Torrance, California

JFK Medical Center, Atlantis, Florida

Baptist Health Jacksonville, Jacksonville, Florida

Miami Cardiac and Vascular/Baptist Hospital, Miami, Florida

Piedmont, Atlanta, Georgia

Northeast Georgia Health System, Gainesville, Georgia

St. Alphonsus Regional Medical Center, Boise, Idaho

Ascension Alexian Brothers, Chicago, Illinois

Midwest Cardiovascular Research and Education Foundation, Elkhart, Indiana

Parkview Research Center, Fort Wayne, Indiana

University of Kansas Medical Center, Kansas City, Kansas

Midwest Heart and Vascular, Overland Park, Kansas

Cardiovascular Research Institute of Kansas, Wichita, Kansas

Tufts Medical, Boston, Massachusetts

Massachusetts General Hospital, Boston, Massachusetts

Sparrow Clinical Research Institute, Lansing, Michigan

William Beaumont Hospital, Royal Oak, Michigan

Ascension St. Mary's, Saginaw, Michigan

St. Joseph Mercy Health System, Ypsilanti, Michigan

University of Minnesota Medical Center, Minneapolis, Minnesota

CentraCare Heart and Vascular Center, Saint Cloud, Minnesota

Boone Hospital, Columbia, Missouri

St. Louis University, Saint Louis, Missouri

Missouri Baptist, Saint Louis, Missouri

Bryan Heart, Lincoln, Nebraska

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Our Lady of Lourdes, Camden, New Jersey

Valley Hospital, Ridgewood, New Jersey

Montefiore Medical Center, Bronx, New York

University at Buffalo, Buffalo, New York

NYU Langone Hospital - Long Island, Mineola, New York

Mount Sinai, New York, New York

Columbia University Medical Center, New York, New York

St. Joseph's Hospital, Syracuse, New York

Novant Health Heart and Vascular Institute, Charlotte, North Carolina

Summa Health System, Akron, Ohio

Mount Carmel, Columbus, Ohio

Oklahoma Heart, Oklahoma City, Oklahoma

Kaiser Permanente Northwest, Clackamas, Oregon

Rhode Island Hospital, Providence, Rhode Island

Methodist Le Bonheur Healthcare, Germantown, Tennessee

Ballad Health CVA Heart Institute, Kingsport, Tennessee

Parkwest Medical Center, Knoxville, Tennessee

Cardiovascular Surgery Clinic/Baptist Memorial, Memphis, Tennessee

HCA Houston Healthcare Medical Center, Houston, Texas

Baylor Scott & White Plano, Plano, Texas

Baylor Scott & White Round Rock, Round Rock, Texas

University of Vermont Medical Center, Burlington, Vermont

Bellin Health System, Green Bay, Wisconsin

Ascension Columbia St. Mary's, Milwaukee, Wisconsin

University of Alberta, Mazankowski Heart Institute, Edmonton, Alberta

Royal Columbian Hospital, New Westminster, British Columbia

Vancouver General Hospital, Vancouver, British Columbia

Centre for Cardiovascular Innovation-Centre d'Innovation Cardiovasculaire (CCI-CIC), Vancouver, British Columbia

St. Paul's Hospital, Vancouver, British Columbia

Saint Boniface, Winnipeg, Manitoba

New Brunswick Heart, Saint John, New Brunswick

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia

Hamilton Health Sciences, Hamilton, Ontario

Ottawa Heart, Ottawa, Ontario

Sunnybrook Hospital, Toronto, Ontario

St. Michael's Hospital, Toronto, Ontario

Montréal Heart, Montréal, Quebec

Centre Hospitalier de l'Université de Montréal, Montréal, Quebec

Sacré-Coeur, Montréal, Quebec

CIUSSS de l'Estrie-CHUS, Sherbrooke, Quebec

Prairie Vascular, Regina, Saskatchewan

Conditions: Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis

Learn More ›

CTSN Embolic Protection Trial

NCT06027788

Recruiting

This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.

Gender:

ALL

Ages:

60 years and above

Trial Updated:

07/15/2025

Locations: CHI St. Vincent Heart Institute, North Little Rock, Arkansas +27 locations

CHI St. Vincent Heart Institute, North Little Rock, Arkansas

Keck Hospital of the University of Southern California, Los Angeles, California

Emory University, Atlanta, Georgia

Indiana University, Bloomington, Indiana

Indiana Ohio Heart, Fort Wayne, Indiana

Ochsner Clinic, New Orleans, Louisiana

Maine Medical Center, Portland, Maine

Johns Hopkins Medicine, Baltimore, Maryland

University of Maryland, College Park, Maryland

Massachusetts General Hospital, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Mayo Clinic, Rochester, Minnesota

Saint Luke's Hospital of Kansas City, Kansas City, Missouri

Montefiore Medical Center, Bronx, New York

Columbia University Medical Center, New York, New York

New York Presbyterian-Cornell Medical Center, New York, New York

NYU Langone Hospital Brooklyn, New York, New York

Northwell Health, New York, New York

Duke University, Durham, North Carolina

University Hospitals, Cleveland, Ohio

Cleveland Clinic, Cleveland, Ohio

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

University of Virginia, Charlottesville, Virginia

West Virginia University, Morgantown, West Virginia

London Health Sciences Centre, London, Ontario

University of Ottawa Heart Institute, Ottawa, Ontario

Montreal Heart Institute, Montréal, Quebec

Hôpital Laval, Quebec City, Quebec

Conditions: Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease, Coronary Artery Disease

Learn More ›

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

NCT05427370

Recruiting

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether C... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/17/2025

Locations: Cedars-Sinai, Los Angeles, California +34 locations

Cedars-Sinai, Los Angeles, California

UofL Health, Inc, Louisville, Kentucky

Mayo Clinic, Rochester, Minnesota

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Medical University of Vienna, Vienna, Not set

Heart Institute, Medical School of the University of Sao Paulo_INCOR, São Paulo, Not set

University of Calgary; Libin Cardiovascular Institute, Calgary, Alberta

Mackenzie Health Sciences Center, Edmonton, Alberta

Fraser Health; Royal Columbian Hospital, New Westminster, British Columbia

Providence Health, Vancouver, British Columbia

Queen Elizabeth II Hospital, Halifax, Nova Scotia

Hamilton General Hospital, Hamilton, Ontario

London Health Sciences Center, University Hospital, London, Ontario

Southlake Regional HC, Newmarket, Ontario

Ottawa Heart Institute, Ottawa, Ontario

Sunnybrook Health Sciences Center, Toronto, Ontario

St. Michael's, Toronto, Ontario

Toronto General Hospital, Toronto, Ontario

Center Hospitalier Universitaire de Montreal, Montréal, Quebec

Montreal Heart Institute, Montréal, Quebec

Hospital Sacre-Coeur, Montréal, Quebec

Institut de Cardiologie Quebec (QC) - Laval, Québec, Quebec

Jilin Heart Hospital, Jilin, Changchun

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Not set

Clinical Hospital Dubrava, Sušak, Zagreb

University Hospital Dusseldorf, Düsseldorf, Not set

G Kuppuswamy Naidu Memorial Hospital (GKNM), Palayam, Tamil Nadu

European Hospital, Via Portuense, Roma, RM

Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, Not set

Medical University of Silesia, Katowice, Not set

Unidade Local de Saude Lisboa Ocidental (ULSLO), Lisboa, Not set

Dedinje Cardiovascular Institute, Belgrade, Not set

Hospital Clinic de Barcelona (ICCV), Barcelona, L'Eixample

Hospital del Vinalopó, Alicante, Not set

Hospital Universitario de Navarra, Pamplona, Not set

Conditions: Coronary Artery Disease, Heart Failure Systolic

Learn More ›

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

NCT05701358

Recruiting

COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/16/2025

Locations: UCLA, Los Angeles, California +112 locations

UCLA, Los Angeles, California

University of California, San Francisco, San Francisco, California

Cardiovascular Research Institute of Kansas, Wichita, Kansas

The Johns Hopkins University School of Medicine, Baltimore, Maryland

University of Michigan, Ann Arbor, Michigan

Metropolitan Cardiology Consultants / Metropolitan Heart and Vascular Institute (MCC/MHVI), Coon Rapids, Minnesota

RWJ Barnabas Health, Jersey City, New Jersey

Montefiore Medical Center, Bronx, New York

Bassett Medical Center, Cooperstown, New York

VA New York Harbor HealthCare System, New York, New York

NYU Grossman School of Medicine, New York, New York

Cleveland Clinic, Cleveland, Ohio

University of Virginia Medical Center, Charlottesville, Virginia

Westmead Hospital, Westmead, New South Wales

Klinik Floridsdorf, Vienna, Not set

McGill University Health Centre (MUHC), Montréal, Quebec

William Osler Health System, Brampton, Not set

University of Alberta Hospital, Mazankowski Heart, Edmonton, Not set

Hamilton Health Sciences, Hamilton, Not set

Kingston Health Sciences Centre, Kingston, Not set

St. Mary's General Hospital, Kitchener, Not set

London Health Sciences Centre, London, Not set

Centre Hospitalier de l'Universite de Montreal, Montréal, Not set

Hopital du Sacre-Coeur de Montreal, Montréal, Not set

Southlake Regional Health Centre, Newmarket, Not set

Nova Scotia Health, Nova Scotia, Not set

University of Ottawa Heart Institute, Ottawa, Not set

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Not set

Regina General Hospital, Regina, Not set

Royal University Hospital, Saskatoon, Not set

Niagara Health, St. Catharines, Not set

Newfoundland and Labrador Health Services, St. John's, Not set

Thunder Bay Regional Health Sciences Centre, Thunder Bay, Not set

St. Michael's Hospital (Unity Health Toronto), Toronto, Not set

Sunnybrook Health Sciences Centre, Toronto, Not set

Ciusss McQ - Chaur, Trois-Rivières, Not set

St Paul's Hospital, Vancouver, Not set

Vancouver General Hospital, Vancouver, Not set

St. Boniface Hospital, Winnipeg, Not set

St. Anne's University Hospital, Brno, Not set

Aalborg University Hospital, Aalborg, Not set

Aarhus University Hospital, Aarhus, Not set

Rigshospitalet - Copenhagen University Hospital, Copenhagen, Not set

Helsinki University Hospital, Helsinki, Not set

TAYS Sydankeskus Oy, Tampere, Not set

Turku University Hospital, Turku, Not set

St. Vinzenz-Hospital, Cologne, Not set

Helios Amper-Klinikum, Dachau, Not set

Universitatsklinikum Frankfurt, Frankfurt, Not set

Marienkrankenhaus, Hamburg, Not set

Schoen Klink Hamburg, Hamburg, Not set

University Heart & Vascular Center Hamburg, Hamburg, Not set

WKK Heide, Heide, Not set

Gottsegen National Cardiovascular Center, Budapest, Not set

University of Szeged, Szeged, Not set

Lisie Hospital, Ernakulam, Kerala

Meditrina Hospital, Kollam, Kerala

Caritas Hospital Trust, Kottayam, Kerala

Apollo Rajshree Hospitals, Indore, Madhya Pradesh

Rukmani Birla Hospital, Jaipur, Rajasthan

Apollo Hospital, Chennai, Tamil Nadu

The Madras Medical Mission, Chennai, Tamil Nadu

Meenakshi Mission Hospital and Research Center, Madurai, Tamil Nadu

Medicover Hospitals, Hyderabad, Not set

Krishna Institute of Medical Sciences, Secunderabad, Not set

Azienda USL Toscana Sud Est, Arezzo, Not set

UOC Cardiologia - Ospedale Maggiore, Bologna, Not set

Azienda Ospedaliero - Universitaria di Ferrara, Ferrara, Not set

Misericordia Hospital, Grosseto, Not set

Azienda USL-IRCCS di Reggio Emilia, Reggio, Reggio Emilia, Not set

Sant Andrea Hospital - Sapienza University, Rome, Not set

Sorlandet Hospital Arendal, Kristiansand, Arendal

Oslo University Hospital Ulleval, Oslo, Not set

Stavanger University Hospital, Stavanger, Not set

University Hospital Tromso, Tromso, Not set

Provincial Specialized Hospital, Legnica, Dolnoslaskie

Miedziowym Centrum Zdrowia S.A. w Lubinie, Lubin, Dolnoslaskie

Medical University of Warsaw, Warsaw, Mazowieckie

Institute for Cardiovascular Diseases Dedinje, Belgrade, Not set

University Clinical Center of Serbia, Belgrade, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital Ramon y Cajal, Madrid, Not set

Hospital Universitario de La Princesa, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Virgen del Rocio, Seville, Not set

Hospital Universitari i Politecnic La Fe, Valencia, Not set

Hospital Clinico Universitario de Valladolid, Valladolid, Not set

Karolinska University Hospital, Huddinge, Not set

Lanssjukhuset RYHOV, Jonkoping,, Not set

Karlstad Central Hospital, Karlstad, Not set

Skane University Hospital, Lund, Not set

Danderyd Hospital, Stockholm, Not set

Umeå University Hospital, Umeå, Not set

Uppsala University Hospital, Uppsala, Not set

East Kent Hospitals University NHS Foundation Trust, Ashford, Not set

Blackpool Teaching Hospitals, Blackpool, Not set

Ninewells Hospital, Dundee, Not set

Harefield Hospital, Harefield, Not set

Kettering General Hospital, Kettering, Not set

University Hospitals of Leicester, Leicester, Not set

Liverpool Heart and Chest Hospital, Liverpool, Not set

Barts Health NHS Trust, London, Not set

Imperial College Healthcare NHS Trust, London, Not set

Royal Free London NHS Foundation Trust, London, Not set

Manchester University NHS Foundation Trust, Manchester, Not set

The James Cook University Hospital, Middlesbrough, Not set

Freeman Hospital, Newcastle upon Tyne, Not set

Royal Berkshire Foundation NHS Trust, Reading, Not set

Sheffield Teaching Hospitals, Sheffield, Not set

East and North Hertfordshire NHS Trust, Stevenage, Not set

Royal Cornwall Hospitals NHS Trust, Truro, Not set

The Royal Wolverhampton NHS Trust, Wolverhampton, Not set

Worcestershire Acute Hospitals NHS Trust, Worcester, Not set

Conditions: Acute Myocardial Infarction, Coronary Artery Disease

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RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)

NCT05134012

Recruiting

This a Phase 3, prospective, open-label, multicenter study of \[15-O\]-H2O injection for PET imaging of subjects with suspected CAD. Approximately 182 evaluable participants with suspected CAD referred for testing will be included in the study at approximately 10 study sites in the United States and Europe. Approximately 215 participants will be enrolled to account for an estimated 15% drop-out rate. Screening assessments will occur prior to enrollment to confirm eligibility. All participants wi... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/23/2025

Locations: University of Iowa, Iowa City, Iowa +10 locations

Conditions: Coronary Artery Disease

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

NCT04124120

Recruiting

The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grfating (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grfating (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocardial infarction, repeat revascularization, and hospital readmission for acute coronary syndrome or heart failure) in a cohort of 2,000 women randomized 1:1 to MAG or SAG (690 from the parent ROMA trial + 1,310 from ROMA:Women). Differences by important clinical and surgical subgroups (patients younger or older than 70 years, diabetics, racial and ethnic minorities, on vs off pump CABG, type of arterial grafts used) will also be evaluated. The women enrolled in the ongoing ROMA trial (anticipated to be approximately 690) will be included in ROMA:Women, increasing efficiency and reducing enrollment time. Hypothesis 1.0. MAG will reduce the incidence of major adverse cardiac and cerebrovascular events. Hypothesis 1.1. The improvement with MAG will be consistent across key subgroups. Aim 2: Determine the impact of MAG vs SAG on generic and disease-specific QOL, physical and mental health symptoms in women undergoing CABG. The investigators will compare generic (SF-12, EQ-5D) and disease-specific (Seattle Angina Questionnaire) QOL and physical and mental health symptoms (PROMIS-29) in a sub-cohort of 500 women randomized 1:1 to MAG or SAG (including those enrolled in ROMA:QOL). Differences by important subgroups (as defined above) will also be evaluated. Hypothesis 2.0. MAG will improve generic and disease-specific QOL compared to SAG. Hypothesis 2.1. MAG will improve physical and mental health symptoms compared to SAG. Hypothesis 2.2. The improvement with MAG will be consistent across key subgroups. Read Less

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

04/04/2025

Locations: Cedars-Sinai Medical Center, Los Angeles, California +140 locations

Cedars-Sinai Medical Center, Los Angeles, California

Pomona Valley Hospital Medical Center, Pomona, California

University of California, San Francisco, San Francisco, California

University of Colorado, Aurora, Colorado

Hartford Hospital, Hartford, Connecticut

Yale University Hospital, New Haven, Connecticut

Emory University, Atlanta, Georgia

University of Chicago, Chicago, Illinois

University of Iowa, Iowa City, Iowa

Johns Hopkins University, Baltimore, Maryland

Baystate Health, Springfield, Massachusetts

University of Massachusetts Chan Medical School, Worcester, Massachusetts

University of Michigan, Ann Arbor, Michigan

Corewell Health William Beaumont University Hospital, Royal Oak, Michigan

Washington University in St. Louis, Saint Louis, Missouri

Nebraska Heart Hospital, Lincoln, Nebraska

Methodist Physicians Health, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Englewood Health, Englewood, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

The Valley Hospital, Ridgewood, New Jersey

NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York

Weill Cornell Medicine, New York, New York

Columbia University Medical Center, New York, New York

Lenox Hill Hospital, New York, New York

New York Presbyterian Queens, Queens, New York

Duke University, Durham, North Carolina

East Carolina University, Greenville, North Carolina

Wake Forest University, Winston-Salem, North Carolina

Cleveland Clinic Foundation, Cleveland, Ohio

Ohio State University, Columbus, Ohio

Genesis Healthcare System, Zanesville, Ohio

University of Pennsylvania, Philadelphia, Pennsylvania

Allegheny General Hospital, Pittsburgh, Pennsylvania

Lankenau Medical Center, Wynnewood, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Baylor Scott & White Research Institute, Dallas, Texas

The University of Texas Medical Health Branch at Galveston, Galveston, Texas

Baylor College of Medicine, Houston, Texas

UT Health San Antonio, San Antonio, Texas

University of Utah, Salt Lake City, Utah

Victorian Heart Hospital, Clayton, Not set

The University of Melbourne, Melbourne, Not set

Medical University of Graz, Graz, Not set

Innsbruck Medical University, Innsbruck, Not set

Kepler University Hospital, Linz, Not set

Medical University of Vienna, Vienna, Not set

Krankenhaus Nord Vienna North Hospital, Vienna, Not set

Institute of Cardiology Porto Alegre, Porto Alegre, Not set

Heart Institute University of São Paulo, São Paulo, Not set

Instituto Dante Pazzanese de Cardiologia, Vila Mariana, Not set

St. Boniface General Hospital, Winnipeg, Manitoba

Horizon Health Network - Saint John Regional Hospital, Saint John, New Brunswick

NL Health Services, St. John's, Newfoundland and Labrador

Hamilton General Hospital, Hamilton, Ontario

London Health Sciences, London, Ontario

University of Ottawa Heart Institute, Ottawa, Ontario

Health Sciences North, Sudbury, Ontario

Sunnybrook Health Sciences, Toronto, Ontario

Toronto General Hospital, Toronto, Ontario

Montreal Heart Institute, Montréal, Quebec

University Hospital of Montreal, Montréal, Quebec

Royal Victoria Hospital, Montréal, Quebec

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Ste Foy, Quebec

Hopital Sacre-Coeur, Montréal, Not set

Fraser Clinical Trials, New Westminster, Not set

Fuwai Hospital China, Beijing, Beijing

Jilin Heart Hospital China, Changchun, Jilin

Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai

Teda Hospital Tianjin China, Tianjin, Tianjin

University Hospital Dubrava, Zagreb, Not set

University Hradec Králové, Hradec Králové, Not set

General University Hospital, Prague, Nové Město, Not set

Aalborg University Hospital, Aalborg, Not set

Rigshospitalet, Copenhagen, Not set

Universitäts-Herzzentrum Bad Krozingen Freiburg, Bad Krozingen, Baden-Wuerttemberg

HDZ NRW Bad Oeynhausen Germany, Bad Oeynhausen, Not set

Deutsches Herzzentrum der Charite, Berlin, Not set

Duisburg Heart Center, Duisburg, Not set

Dusseldorf University, Düsseldorf, Not set

University Hospital Erlangen, Erlangen, Not set

Essen University, Essen, Not set

Frankfurt University, Frankfurt, Not set

University Hospital of Giessen and Marburg, Gießen, Not set

University Medical Center of Göttingen, Göttingen, Not set

Jena University Hospital, Jena, Not set

Heart Center Herzzentrum, Leipzig, Leipzig, Not set

Robert-Bosch-Hospital Stuttgart Germany, Stuttgart, Not set

Krankenhaus der Barmherzigen Brüder Trier, Trier, Not set

G Kuppuswamy Naidu Memorial Hospital (GKNM), Coimbatore, Tamil Nadu

Star Hospitals - Hyderabad, India, Hyderabad, Telangana

Rambam Health Care Campus, Haifa, Not set

Anthea Hospital, Bari, Not set

Humanitas Gavazzeni of Bergamo, Bergamo, Not set

Fondazione Poliambulanza, Brescia, Not set

Maria Cecilia Hospital GVM, Cotignola, Not set

Careggi University Hospital, Florence, Not set

European Hospital, Roma, Not set

Universita' Cattolica del Sacro Cuore, Roma, Not set

Ospedale Le Molinette, Torino, Torino, Not set

Tokyo Medical and Dental University, Bunkyō-Ku, Tokyo

Saitama Medical University Japan, Saitama, Not set

Seoul National University Hospital, Seoul, Not set

Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seúl, Not set

Leiden University Medical Center, Leiden, South Holland

Erasmus Medical Center, Rotterdam, South Holland

Maastricht University Medical Centre, Maastricht, Not set

Acibadem-Sistina Hospital, Skopje, Not set

Medical University Gdansk, Gdańsk, Not set

Medical University of Silesia, Katowice, Not set

Zbigniew Religa Lower Silesian Heart Disease Centre, Zabrze, Not set

University Hospital Coimbra, Coimbra, Not set

Centro Hospitalar Lisboa Ocidental, Lisboa, Not set

Centro Hospitalar e Universitário Sao Joao, Porto, Not set

Centro Hospitalar e Universitário Sao João, Porto, Not set

National Research Medical Center of the Russian Academy of Sciences - Tomsk, Russia, Tomsk, Not set

Dedinje Cardiovascular Institute, Belgrade, Not set

National University of Singapore, Singapore, Not set

Hospital Universitario del Vinalopo, Elx, Alicante

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital Clinico de San Carlos, Madrid, Not set

NavarraBiomed, Pamplona, Not set

Sahlgrenska University Hospital, Gothenburg, Not set

Karonlinska University Hospital, Stockholm, Not set

National Taiwan University Hospital, Zhongzheng, Taipei

Blackpool Teaching Hospitals NHS Trust, Blackpool, Lancashire

Oxford University Hospitals NHS Trust, Multiple Locations, Oxford

University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, Staffordshire

Royal Papworth NHS Foundation Trust, Cambridge, Not set

NHS Golden Jubilee, Clydebank, Not set

The Royal Infirmary of Edinburgh, Edinburgh, Not set

Hull University Hospitals, Hull, Not set

University Hospitals of Leicester, Leicester, Not set

Liverpool Heart and Chest Hospital Foundation Trust, Liverpool, Not set

Guy's and St Thomas' NHS Foundation Trust, London, Not set

Imperial College Healthcare NHS Trust, London, Not set

St George's University Hospitals, London, Not set

Manchester University NHS Trust, Manchester, Not set

South Tees Hospitals NHS Trust, Middlesbrough, Not set

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, Not set

Royal Wolverhampton NHS Trust, Wolverhampton, Not set

Conditions: Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting

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De-Adoption of Beta-Blockers in Patients With Stable Ischemic Heart Disease

NCT05081999

Recruiting

Patients with heart disease are often prescribed many medications and these patients may experience drug interactions or negative drug related side effects. With newer medications and treatments available, it is not well known whether older drugs, such as beta-blockers, are still an effective and safe option for treating heart disease. Some evidence suggests beta-blockers should be continued, whereas other evidence suggests beta-blockers might cause unnecessary harm. The study hopes to determine... Read More

Gender:

ALL

Ages:

21 years and above

Trial Updated:

02/03/2025

Locations: University of Alberta Hospital, Edmonton, Alberta

Conditions: Stable Ischemic Heart Disease, Coronary Artery Disease, Beta-blocker Therapy

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CCTA to Optimize Diagnostic Yield of Invasive Angiography With AI

NCT06648239

Recruiting

Coronary artery disease (CAD) is a leading cause of death. The gold-standard test used to diagnose CAD is invasive coronary angiography (ICA). However, nearly half the patients who receive ICA are found to have no disease or non-significant disease. This means that while they receive a diagnosis, they do not receive any therapeutic benefit. This is concerning because ICA is expensive and it carries a risk to patients. A non-invasive diagnostic test, cardiac computed tomographic angiography (CCTA... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/28/2025

Locations: Hamilton General Hospital, Hamilton, Ontario +2 locations

Conditions: Coronary Artery Disease

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Canagliflozin Targeting Vascular Inflammation

NCT05427084

Recruiting

CANTOR SING is a pilot single center double blinded randomized study. The investigators will compare the effect of canagliflozin (300 mg daily - intervention arm) vs. placebo (control group) on the FDG aortic uptake in patients with stable CAD (over 60 days post-myocardial infarction) after a 6-month period of treatment. The investigators plan to enroll 8 patients in each arm (total sample size: 16 patients). Primary endpoint is the change in FDG aortic uptake between baseline and 6 months in ea... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

12/05/2024

Locations: University of Ottawa Heart Institute, Ottawa, Ontario

Conditions: Diabetes Type 2, Coronary Artery Disease

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A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease

NCT04464655

Recruiting

This study aims to identify and assess new CMR techniques that can improve current CMR protocols.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/22/2024

Locations: McGill University Health Center, Montreal, Quebec

Conditions: Coronary Artery Disease, Myocarditis, Infiltrative Cardiomyopathy, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Aortic Valve Stenosis, Aortic Valve Regurgitation, Pericardial Effusion, Congenital Heart Disease, Vascular Anomaly

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MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)

NCT05487612

Recruiting

MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS). It is designed to ultimately address the emerging effectiveness of MiECC systems in the light of modern perfusion practice worldwide. The primary hypothesis is that MiECC, as compared to conventional CPB (cCPB), reduces the proportion of patients experiencing serious perfusion-related posto... Read More

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

08/06/2024

Locations: Perfusion Services University Health Network, Toronto General Hospital, Toronto, Not set +11 locations

Conditions: Coronary Artery Disease, Aortic Valve Stenosis, Extracorporeal Circulation; Complications

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