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Cisplatin Treatment Options in Canada
A collection of 326 research studies where Cisplatin is the interventional treatment. These studies are located in the Canada . Cisplatin is used for conditions such as Head and Neck Cancer, Lung Cancer and Non-small Cell Lung Cancer.
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Dose Escalation and Expansion Study of GSK3359609 in Participants With Selected Advanced Solid Tumors (INDUCE-1)
Completed
GSK3359609 is an anti-Inducible T cell Co-Stimulator (ICOS) receptor agonist antibody intended for the treatment of cancers of different histology. This is a first-time-in-human (FTIH), open-label, multicenter study designed to investigate the safety, pharmacology, and preliminary antitumor activity in participants with selected, advanced or recurrent solid tumors with the aim to establish recommended dose(s) of GSK3359609 for further exploration as monotherapy and in combination with pembrolizu... Read More
GSK3359609 is an anti-Inducible T cell Co-Stimulator (ICOS) receptor agonist antibody intended for the treatment of cancers of different histology. This is a first-time-in-human (FTIH), open-label, multicenter study designed to investigate the safety, pharmacology, and preliminary antitumor activity in participants with selected, advanced or recurrent solid tumors with the aim to establish recommended dose(s) of GSK3359609 for further exploration as monotherapy and in combination with pembrolizumab or chemotherapy regimens. The study is comprised of two primary parts, each composed of two phases: Part 1: GSK3359609 monotherapy with Part 1A as dose escalation phase and Part 1B as cohort expansion phase; Part 2: GSK3359609 combination therapy with Part 2A pembrolizumab or GSK3174998 or chemotherapy or pembrolizumab plus chemotherapy or dostarlimab plus cobolimab or Bintrafusp alfa combination dose escalation phase and Part 2B expansion phase with pembrolizumab. The primary objective of the study is to determine the safety, tolerability, maximum tolerated dose or the maximum administered dose of GSK3359609 alone or in combination. Read Less
Gender:
ALL
Ages:
Between 18 years and 93 years
Trial Updated:
11/08/2024
Locations: GSK Investigational Site, Duarte, California +27 locations
GSK Investigational Site, Duarte, California
GSK Investigational Site, Los Angeles, California
GSK Investigational Site, Sarasota, Florida
GSK Investigational Site, New York, New York
GSK Investigational Site, New York, New York
GSK Investigational Site, Oklahoma City, Oklahoma
GSK Investigational Site, Philadelphia, Pennsylvania
GSK Investigational Site, Nashville, Tennessee
GSK Investigational Site, Nashville, Tennessee
GSK Investigational Site, Heidelberg, Victoria
GSK Investigational Site, Melbourne, Victoria
GSK Investigational Site, Nedlands, Western Australia
GSK Investigational Site, Toronto, Ontario
GSK Investigational Site, Shnghai, Not set
GSK Investigational Site, Bordeaux Cedex, Not set
GSK Investigational Site, Lyon cedex 08, Not set
GSK Investigational Site, Paris, Not set
GSK Investigational Site, Villejuif cedex, Not set
GSK Investigational Site, Siena, Toscana
GSK Investigational Site, Chiba, Not set
GSK Investigational Site, Osaka, Not set
GSK Investigational Site, Tokyo, Not set
GSK Investigational Site, Amsterdam, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Mága, Not set
GSK Investigational Site, Sevilla, Not set
Conditions: Neoplasms
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
Active Not Recruiting
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional chemotherapy in treating cervical cancer.
PURPOSE: This randomized phase III trial is studying chemotherapy... Read More
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional chemotherapy in treating cervical cancer.
PURPOSE: This randomized phase III trial is studying chemotherapy and pelvic radiation therapy to see how well they work when given with or without additional chemotherapy in treating patients with high-risk early-stage cervical cancer after radical hysterectomy. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +124 locations
University of Alabama at Birmingham, Birmingham, Alabama
Providence Hospital, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Arizona Center for Cancer Care-Peoria, Peoria, Arizona
Saint Joseph's Hospital and Medical Center, Phoenix, Arizona
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California
Mercy San Juan Medical Center, Carmichael, California
City of Hope Medical Center, Duarte, California
Saint Joseph Hospital - Orange, Orange, California
Pomona Valley Hospital Medical Center, Pomona, California
Mercy Cancer Center, Sacramento, California
Mercy General Hospital Radiation Oncology Center, Sacramento, California
Saint Helena Hospital, Saint Helena, California
University of California At San Diego, San Diego, California
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
Hartford Hospital, Hartford, Connecticut
The Hospital of Central Connecticut, New Britain, Connecticut
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
Memorial Healthcare System - Joe DiMaggio Children's Hospital, Hollywood, Florida
Jackson Memorial Hospital-Holtz Children's Hospital, Miami, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Baptist Hospital of Miami, Miami, Florida
Florida Hospital, Orlando, Florida
Grady Health System, Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
Northeast Georgia Medical Center, Gainesville, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Saint Joseph's-Candler Health System, Savannah, Georgia
Queen's Medical Center, Honolulu, Hawaii
University of Hawaii, Honolulu, Hawaii
Saint Alphonsus Regional Medical Center, Boise, Idaho
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
Saint Vincent Anderson Regional Hospital/Cancer Center, Anderson, Indiana
Saint Francis Hospital and Health Centers, Beech Grove, Indiana
Franciscan Saint Margaret Health-Hammond Campus, Hammond, Indiana
Franciscan Saint Francis Health-Indianapolis, Indianapolis, Indiana
Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana
University of Iowa Hospitals and Clinics, Iowa City, Iowa
Mercy Medical Center - North Iowa, Mason City, Iowa
University of Kansas Medical Center, Kansas City, Kansas
Kansas City Cancer Centers-Southwest, Overland Park, Kansas
Via Christi Regional Medical Center, Wichita, Kansas
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Greater Baltimore Medical Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Central Maryland Radiation Oncology in Howard County, Columbia, Maryland
Holy Cross Hospital, Silver Spring, Maryland
Hickman Cancer Center, Adrian, Michigan
Saint John Hospital and Medical Center, Detroit, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Saint Joseph Mercy Port Huron, Port Huron, Michigan
Saint John Macomb-Oakland Hospital, Warren, Michigan
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Mayo Clinic, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Kansas City Cancer Center - South, Kansas City, Missouri
Kansas City Cancer Centers - North, Kansas City, Missouri
Kansas City Cancer Center-Lee's Summit, Lee's Summit, Missouri
Phelps County Regional Medical Center, Rolla, Missouri
Saint John's Mercy Medical Center, Saint Louis, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
Nebraska Methodist Hospital, Omaha, Nebraska
The Nebraska Medical Center, Omaha, Nebraska
Elliot Hospital, Manchester, New Hampshire
Cooper Hospital University Medical Center, Camden, New Jersey
Morristown Memorial Hospital, Morristown, New Jersey
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County, Mount Holly, New Jersey
UMDNJ - New Jersey Medical School, Newark, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
Montefiore Medical Center-Weiler Division, Bronx, New York
Montefiore Medical Center, Bronx, New York
State University of New York Downstate Medical Center, Brooklyn, New York
Memorial Sloan-Kettering Cancer Center, New York, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Carolinas Medical Center, Charlotte, North Carolina
Summa Akron City Hospital/Cooper Cancer Center, Akron, Ohio
Akron General Medical Center, Akron, Ohio
Summa Barberton Hospital, Barberton, Ohio
University of Cincinnati, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus, Ohio
Summa Health Center at Lake Medina, Medina, Ohio
UHHS-Chagrin Highlands Medical Center, Orange Village, Ohio
Southern Ohio Medical Center, Portsmouth, Ohio
Robinson Radiation Oncology, Ravenna, Ohio
Cancer Care Center, Incorporated, Salem, Ohio
Ireland Cancer Center at Firelands Regional Medical Center, Sandusky, Ohio
Flower Hospital, Sylvania, Ohio
University of Toledo, Toledo, Ohio
UHHS-Westlake Medical Center, Westlake, Ohio
Cancer Treatment Center, Wooster, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Lankenau Hospital, Wynnewood, Pennsylvania
Women and Infants Hospital, Providence, Rhode Island
Rapid City Regional Hospital, Rapid City, South Dakota
Sanford Cancer Center-Oncology Clinic, Sioux Falls, South Dakota
University of Tennessee - Knoxville, Knoxville, Tennessee
University of Texas Southwestern Medical Center, Dallas, Texas
M D Anderson Cancer Center, Houston, Texas
Methodist Hospital, Houston, Texas
Intermountain Medical Center, Murray, Utah
McKay-Dee Hospital Center, Ogden, Utah
Dixie Medical Center Regional Cancer Center, Saint George, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Seattle Cancer Care Alliance, Seattle, Washington
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington
Wheeling Hospital, Wheeling, West Virginia
Saint Vincent Hospital, Green Bay, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
McGill University Department of Oncology, Montreal, Quebec
Pamela Youde Nethersole Eastern Hospital, Chai Wan, Not set
Seoul National University Bundang Hospital, Seongnam City, Kyeonggi-do
Seoul National University Hospital, Seoul, Not set
Gangnam Severance Hospital, Seoul, Not set
Korea Cancer Center Hospital, Seoul, Not set
Conditions: Cervical Cancer
Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
Active Not Recruiting
There are two study questions we are asking in this randomized phase II/III trial based on a blood biomarker, Epstein Barr virus (EBV) deoxyribonucleic acid (DNA) for locoregionally advanced non-metastatic nasopharyngeal cancer. All patients will first undergo standard concurrent chemotherapy and radiation therapy. When this standard treatment is completed, if there is no detectable EBV DNA in their plasma, then patients are randomized to either standard adjuvant cisplatin and fluorouracil chemo... Read More
There are two study questions we are asking in this randomized phase II/III trial based on a blood biomarker, Epstein Barr virus (EBV) deoxyribonucleic acid (DNA) for locoregionally advanced non-metastatic nasopharyngeal cancer. All patients will first undergo standard concurrent chemotherapy and radiation therapy. When this standard treatment is completed, if there is no detectable EBV DNA in their plasma, then patients are randomized to either standard adjuvant cisplatin and fluorouracil chemotherapy or observation. If there is still detectable levels of plasma EBV DNA, patients will be randomized to standard cisplatin and fluorouracil chemotherapy versus gemcitabine and paclitaxel. Radiation therapy uses high energy x rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, fluorouracil, gemcitabine hydrochloride, and paclitaxel work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving cisplatin and fluorouracil is more effective than gemcitabine hydrochloride and paclitaxel after radiation therapy in treating patients with nasopharyngeal cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +214 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
The Kirklin Clinic at Acton Road, Birmingham, Alabama
Banner University Medical Center - Tucson, Tucson, Arizona
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California
Mills-Peninsula Medical Center, Burlingame, California
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California
City of Hope Comprehensive Cancer Center, Duarte, California
Kaiser Permanente Dublin, Dublin, California
Fresno Cancer Center, Fresno, California
UC San Diego Moores Cancer Center, La Jolla, California
Memorial Medical Center, Modesto, California
Kaiser Permanente Oakland-Broadway, Oakland, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Palo Alto Medical Foundation Health Care, Palo Alto, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova, California
Rohnert Park Cancer Center, Rohnert Park, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
The Permanente Medical Group-Roseville Radiation Oncology, Roseville, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
South Sacramento Cancer Center, Sacramento, California
California Pacific Medical Center-Pacific Campus, San Francisco, California
UCSF Medical Center-Mount Zion, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
City of Hope South Pasadena, South Pasadena, California
Kaiser Permanente Cancer Treatment Center, South San Francisco, California
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California
Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville, California
SCL Health Cancer Centers of Colorado - Lutheran Medical Center, Golden, Colorado
North Colorado Medical Center, Greeley, Colorado
McKee Medical Center, Loveland, Colorado
Parker Adventist Hospital, Parker, Colorado
SCL Health Lutheran Medical Center, Wheat Ridge, Colorado
Yale University, New Haven, Connecticut
Helen F Graham Cancer Center, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
Baptist MD Anderson Cancer Center, Jacksonville, Florida
Moffitt Cancer Center, Tampa, Florida
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
The Cancer Center of Hawaii-Pali Momi, 'Aiea, Hawaii
Queen's Medical Center, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho
Rush - Copley Medical Center, Aurora, Illinois
Northwestern University, Chicago, Illinois
John H Stroger Jr Hospital of Cook County, Chicago, Illinois
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Crossroads Cancer Center, Effingham, Illinois
Memorial Medical Center, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Memorial Hospital of South Bend, South Bend, Indiana
Iowa Methodist Medical Center, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Ascension Via Christi Hospitals Wichita, Wichita, Kansas
Wesley Medical Center, Wichita, Kansas
Greater Baltimore Medical Center, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Tufts Medical Center, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
Saint Joseph Mercy Hospital, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
McLaren Cancer Institute-Bay City, Bay City, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Saint Joseph Mercy Canton, Canton, Michigan
McLaren Cancer Institute-Clarkston, Clarkston, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
McLaren Cancer Institute-Flint, Flint, Michigan
Singh and Arora Hematology Oncology PC, Flint, Michigan
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan
Mid-Michigan Physicians-Lansing, Lansing, Michigan
Sparrow Hospital, Lansing, Michigan
McLaren Cancer Institute-Lapeer Region, Lapeer, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
McLaren Cancer Institute-Macomb, Mount Clemens, Michigan
McLaren Cancer Institute-Central Michigan, Mount Pleasant, Michigan
McLaren Cancer Institute-Northern Michigan, Petoskey, Michigan
Saint Joseph Mercy Oakland, Pontiac, Michigan
McLaren-Port Huron, Port Huron, Michigan
Ascension Saint Mary's Hospital, Saginaw, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
Fairview Ridges Hospital, Burnsville, Minnesota
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Unity Hospital, Fridley, Minnesota
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
North Memorial Medical Health Center, Robbinsdale, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Regions Hospital, Saint Paul, Minnesota
Rice Memorial Hospital, Willmar, Minnesota
Saint Francis Medical Center, Cape Girardeau, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Delbert Day Cancer Institute at PCRMC, Rolla, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
Saint James Community Hospital and Cancer Treatment Center, Butte, Montana
Nebraska Methodist Hospital, Omaha, Nebraska
Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada
Radiation Oncology Centers of Nevada Southeast, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Saint Mary's Regional Medical Center, Reno, Nevada
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
Maimonides Medical Center, Brooklyn, New York
Memorial Sloan Kettering Commack, Commack, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
New York Proton Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Cleveland Clinic Akron General, Akron, Ohio
Geauga Hospital, Chardon, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Mercy Cancer Center-Elyria, Elyria, Ohio
Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio
North Coast Cancer Care, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
UHHS-Westlake Medical Center, Westlake, Ohio
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma
Legacy Mount Hood Medical Center, Gresham, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania
Lewistown Hospital, Lewistown, Pennsylvania
Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Prisma Health Cancer Institute - Greer, Greer, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
M D Anderson Cancer Center, Houston, Texas
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah
Sandra L Maxwell Cancer Center, Cedar City, Utah
Logan Regional Hospital, Logan, Utah
Intermountain Medical Center, Murray, Utah
McKay-Dee Hospital Center, Ogden, Utah
Utah Valley Regional Medical Center, Provo, Utah
Riverton Hospital, Riverton, Utah
Saint George Regional Medical Center, Saint George, Utah
Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah
Inova Schar Cancer Institute, Fairfax, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Legacy Salmon Creek Hospital, Vancouver, Washington
Langlade Hospital and Cancer Center, Antigo, Wisconsin
HSHS Sacred Heart Hospital, Eau Claire, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Marshfield Medical Center, Marshfield, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Ascension Saint Michael's Hospital, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Diagnostic and Treatment Center, Weston, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Peter MacCallum Cancer Centre, Melbourne, Victoria
Tom Baker Cancer Centre, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
London Regional Cancer Program, London, Ontario
University Health Network-Princess Margaret Hospital, Toronto, Ontario
McGill University Department of Oncology, Montreal, Quebec
The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec
Jewish General Hospital, Montreal, Quebec
Chinese University of Hong Kong-Prince of Wales Hospital, Shatin, Hong Kong
Zhongshan Hospital Fudan University, Guangdong Province, Shanghai
Sun Yat-sen University Cancer Center, Guangzhou, Not set
Pamela Youde Nethersole Eastern Hospital, Chai Wan, Not set
Centro Comprensivo de Cancer de UPR, San Juan, Not set
National Cancer Centre Singapore, Singapore, Not set
National Taiwan University Hospital, Taipei, Not set
Chang Gung Hospital-Lin Kou Medical Center, Taoyuan, Not set
Conditions: Epstein-Barr Virus Infection, Stage II Nasopharyngeal Carcinoma, Stage III Nasopharyngeal Carcinoma, Stage IVA Nasopharyngeal Carcinoma, Stage IVB Nasopharyngeal Carcinoma
Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-789/KEYNOTE-789)
Completed
The purpose of this study is to evaluate the efficacy and safety of pemetrexed plus platinum chemotherapy (carboplatin or cisplatin) with or without pembrolizumab (MK-3475; KEYTRUDA®) in the treatment of adults with the following types of tyrosine kinase inhibitor (TKI)-resistant, epidermal growth factor receptor (EGFR)-mutated, metastatic non-squamous non-small cell lung cancer (NSCLC) tumors: 1) TKI-failures (including osimertinib \[TAGRISSO®\] failure) with T790M-negative mutation tumors, 2)... Read More
The purpose of this study is to evaluate the efficacy and safety of pemetrexed plus platinum chemotherapy (carboplatin or cisplatin) with or without pembrolizumab (MK-3475; KEYTRUDA®) in the treatment of adults with the following types of tyrosine kinase inhibitor (TKI)-resistant, epidermal growth factor receptor (EGFR)-mutated, metastatic non-squamous non-small cell lung cancer (NSCLC) tumors: 1) TKI-failures (including osimertinib \[TAGRISSO®\] failure) with T790M-negative mutation tumors, 2) T790M-positive mutation tumors with prior exposure to osimertinib, and 3) first-line osimertinib failure regardless of T790M mutation status.
The primary study hypotheses are that the combination of pembrolizumab plus chemotherapy has superior efficacy compared to saline placebo plus chemotherapy in terms of: 1) Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) based on blinded independent central review, and 2) Overall Survival (OS). This study will be considered to have met its success criteria if the combination of pembrolizumab plus chemotherapy is superior to saline placebo plus chemotherapy in terms of PFS or OS.
Upon study completion, participants are discontinued and may be enrolled in a pembrolizumab extension study, if available. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Cedars-Sinai Medical Center ( Site 0070), Los Angeles, California +157 locations
Cedars-Sinai Medical Center ( Site 0070), Los Angeles, California
Pacific Cancer Care ( Site 0058), Monterey, California
UC Irvine Medical Center/Chao Family Comprehensive Cancer Center ( Site 0092), Orange, California
St. Joseph Heritage Healthcare ( Site 0003), Santa Rosa, California
North Shore University Health System ( Site 0030), Evanston, Illinois
Siouxland Regioinal Cancer Center dba June E. Nylen Cancer Center ( Site 0065), Sioux City, Iowa
Southdale Cancer Care, University of Minnesota Medical Center- Edina ( Site 0048), Edina, Minnesota
Saint Lukes Hospital of Kansas City ( Site 0060), Kansas City, Missouri
New York Oncology Hematology P.C ( Site 8000), Albany, New York
Monter Cancer Center ( Site 0054), Lake Success, New York
Memorial Sloan Kettering Cancer Center-Rockerfeller Patient Pavilion ( Site 0049), New York, New York
White Plains Hospital Center for Cancer Care ( Site 0014), White Plains, New York
Providence Portland Medical Center ( Site 0097), Portland, Oregon
Kaiser Permanente Northwest ( Site 0037), Portland, Oregon
Parkland Health & Hospital System ( Site 2102), Dallas, Texas
University of Texas Southwestern Medical Center at Dallas ( Site 0035), Dallas, Texas
Utah Cancer Specialists ( Site 0001), Salt Lake City, Utah
Emily Couric Clinical Cancer Center ( Site 0020), Charlottesville, Virginia
Froedtert Hospital & the Medical College of Wisconsin ( Site 0041), Milwaukee, Wisconsin
Chris OBrien Lifehouse ( Site 0200), Camperdown, New South Wales
Westmead Hospital ( Site 0201), Westmead, New South Wales
Eastern Health ( Site 0202), Box Hill, Victoria
Austin Health ( Site 0203), Heidelberg, Victoria
Liga Norte Riograndense Contra o Cancer ( Site 1909), Natal, Rio Grande Do Norte
Hospital de Caridade de Ijui ( Site 1907), Ijui, Rio Grande Do Sul
Hospital Bruno Born ( Site 1913), Lajeado, Rio Grande Do Sul
Hospital de Clinicas de Porto Alegre ( Site 1905), Porto Alegre, Rio Grande Do Sul
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1904), Porto Alegre, Rio Grande Do Sul
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 1911), Barretos, Sao Paulo
Hosp. Clinicas da Fac. de Medicina de Ribeirao Preto - USP ( Site 1912), Ribeirao Preto, Sao Paulo
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1903), Sao Paulo, Not set
William Osler Health System ( Site 0100), Brampton, Ontario
Sunnybrook Health Sciences, Odette Cancer Centre ( Site 0102), Toronto, Ontario
Princess Margaret Cancer Centre ( Site 0104), Toronto, Ontario
Jewish General Hospital ( Site 0105), Montreal, Quebec
The First Affiliated Hospital of Anhui Medical University ( Site 0721), Hefei, Anhui
Cancer Hospital Chinese Academy of Medical Sciences ( Site 0717), Beijing, Beijing
Peking Union Medical College Hospital ( Site 0703), Beijing, Beijing
Beijing Cancer Hospital ( Site 0718), Beijing, Beijing
Southwest Hospital, The Third Military Medical University ( Site 0725), Chongqing, Chongqing
Fujian Cancer Hospital ( Site 0723), Fuzhou, Fujian
The Affiliated Tumour Hospital of Harbin Medical University ( Site 0706), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 0711), Zhengzhou, Henan
Xiangya Hospital of Central South University ( Site 0710), Changsha, Hunan
Hunan Cancer Hospital ( Site 0722), Changsha, Hunan
Jiangsu Cancer Hospital ( Site 0719), Nanjing, Jiangsu
The First Hospital of Jilin University ( Site 0702), Chang chun, Jilin
Jilin Cancer Hospital ( Site 0705), Changchun, Jilin
Shanghai Chest Hospital ( Site 0700), Shanghai, Shanghai
Zhongshan Hospital Fudan University ( Site 0712), Shanghai, Shanghai
Tangdu Hospital ( Site 0708), XI An, Shanxi
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0709), XI An, Shanxi
Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0701), Urumqi, Xinjiang
The First Affiliated Hospital.Zhejiang University ( Site 0713), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital School of Medicine, Zhejiang University ( Site 0715), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 0716), Hangzhou, Zhejiang
Centre Leon Berard ( Site 0801), Lyon, Auvergne
CHU Caen Service de Pneumologie ( Site 0804), Caen, Calvados
Centre Georges Francois Leclerc ( Site 0809), Dijon, Cote-d'Or
Hopital Jean Minjoz Besancon ( Site 0805), Besancon, Doubs
Hopital Prive d'Antony ( Site 0811), Antony, Hauts-de-Seine
C.H.U. de Tours - Hopital Bretonneau ( Site 0806), Tours, Indre-et-Loire
Centre D Oncologie de Gentilly ( Site 0810), Nancy, Meurthe-et-Moselle
Clinique Victor Hugo ( Site 0802), Le Mans, Sarthe
CHU Poitiers ( Site 0803), Poitiers, Vienne
Robert Bosch Krankenhaus Klinik Schillerhoehe ( Site 0904), Gerlingen, Baden-Wurttemberg
Universitaetsklinikum Mannheim ( Site 0911), Mannheim, Baden-Wurttemberg
Klinikum Wuerzburg Mitte gGmbH ( Site 0901), Wuerzburg, Bayern
Pius Hospital Oldenburg ( Site 0905), Oldenburg, Niedersachsen
Florence Nightingale Krankenhaus ( Site 0912), Duesseldorf, Nordrhein-Westfalen
Kliniken Essen-Mitte ( Site 0900), Essen, Nordrhein-Westfalen
Universitaetsklinikum Muenster ( Site 0906), Muenster, Nordrhein-Westfalen
Medizinische Fakultaet Carl Gustav Carus der TU Dresden ( Site 0907), Dresden, Sachsen
Asklepios Klinikum Hamburg ( Site 0908), Hamburg, Not set
Hong Kong Integrated Oncology Centre ( Site 0304), Hong Kong, Not set
Queen Mary Hospital ( Site 0301), Hong Kong, Not set
Queen Mary Hospital ( Site 0303), Hong Kong, Not set
Hong Kong United Oncology Centre ( Site 0306), Kowloon, Not set
Tuen Mun Hospital ( Site 0305), Tuen Mun, Not set
Barzilai Medical Center ( Site 1706), Ashkelon, HaDarom
Soroka Medical Center ( Site 1702), Beer-Sheva, HaDarom
Meir Medical Center ( Site 1701), Kfar-Saba, HaMerkaz
Rabin Medical Center ( Site 1704), Petah Tikva, HaMerkaz
Ha Emek Medical Center ( Site 1707), Afula, HaTsafon
Rambam Medical Center ( Site 1703), Haifa, Heifa
Chaim Sheba Medical Center. ( Site 1700), Ramat Gan, Tell Abib
Sourasky Medical Center ( Site 1705), Tel Aviv, Tell Abib
Istituto Europeo di Oncologia ( Site 1303), Milano, Lombardia
Ospedale San Vincenzo di Taormina ( Site 1302), Taormina, Messina
AOU San Luigi Gonzaga di Orbassano ( Site 1300), Orbassano, Torino
IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1305), Bari, Not set
Azienda Ospedaliero Universitaria Careggi ( Site 1301), Firenze, Not set
Azienda Ospedaliera dei Colli V. Monaldi ( Site 1306), Napoli, Not set
Universita Campus Bio-Medico di Roma ( Site 1304), Roma, Not set
National Hospital Organization Nagoya Medical Center ( Site 0608), Nagoya, Aichi
Aichi Cancer Center Hospital ( Site 0612), Nagoya, Aichi
Fujita Health University Hospital ( Site 0619), Toyoake, Aichi
National Cancer Center Hospital East ( Site 0601), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 0616), Matsuyama, Ehime
Hyogo Cancer Center ( Site 0604), Akashi, Hyogo
Kanazawa University Hospital ( Site 0617), Kanazawa, Ishikawa
Kanagawa Cancer Center ( Site 0609), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 0606), Hirakata, Osaka
Shizuoka Cancer Center Hospital and Research Institute ( Site 0602), Sunto-gun, Shizuoka
National Hospital Organization Kyushu Medical Center ( Site 0621), Fukuoka, Not set
Kyushu University Hospital ( Site 0605), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 0610), Niigata, Not set
Okayama University Hospital ( Site 0614), Okayama, Not set
Osaka International Cancer Institute ( Site 0611), Osaka, Not set
National Cancer Center Hospital ( Site 0603), Tokyo, Not set
Toranomon Hospital ( Site 0615), Tokyo, Not set
Tokyo Metropolitan Komagome Hospital ( Site 0618), Tokyo, Not set
Wakayama Medical University Hospital ( Site 0613), Wakayama, Not set
Chungbuk National University Hospital ( Site 0404), Cheongju si, Chungcheongbuk-do [Chungbuk]
Gachon University Gil Medical Center ( Site 0408), Incheon, Incheon-gwangyeoksi [Incheon]
National Cancer Center ( Site 0400), Gyeonggi-do, Kyonggi-do
Seoul National University Bundang Hospital ( Site 0405), Seongnam-si, Kyonggi-do
Seoul National University Hospital ( Site 0402), Seoul, Seoul-teukbyeolsi [Seoul]
Asan Medical Center ( Site 0407), Seoul, Seoul-teukbyeolsi [Seoul]
Samsung Medical Center ( Site 0403), Seoul, Seoul-teukbyeolsi [Seoul]
The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 0406), Seoul, Seoul-teukbyeolsi [Seoul]
Ulsan University Hospital ( Site 0401), Ulsan, Ulsan-Kwangyokshi
Instituto Jaliscience de Cancerologia ( Site 2000), Guadalajara, Jalisco
Medica Sur S.A.B de C.V. ( Site 2003), Mexico City, Not set
Oaxaca Site Management Organization SC ( Site 2001), Oaxaca, Not set
Instituto Nacional de Cancerologia. ( Site 2007), Tlalpan, Not set
Hospitalo Univ. Germans Trias i Pujol ( Site 1100), Badalona, Barcelona [Barcelona]
Hospital de la Santa Creu i Sant Pau ( Site 1102), Barcelona, Barcelona [Barcelona]
Hospital Universitari Vall d Hebron ( Site 1106), Barcelona, Barcelona [Barcelona]
Hospital Ramon y Cajal ( Site 1101), Madrid, Not set
Hospital Universitario 12 de Octubre ( Site 1103), Madrid, Not set
Complejo Hospitalario Carlos Haya de Malaga ( Site 1107), Malaga, Not set
Hospital Universitario Virgen Macarena ( Site 1104), Sevilla, Not set
Linkopings Universitetssjukhus ( Site 1504), Linkoping, Ostergotlands Lan [se-05]
Skanes Universitetssjukhus Lund ( Site 1503), Lund, Skane Lan [se-12]
Karolinska Universitetssjukhuset Solna ( Site 1500), Solna, Stockholms Lan [se-01]
Sahlgrenska Universitetssjukhuset ( Site 1502), Goteborg, Vastra Gotalands Lan [se-14]
Taipei Tzu Chi Hospital ( Site 0512), New Taipei City, New Taipei
Changhua Christian Hospital ( Site 0509), Changhua, Not set
National Taiwan University Hospital Hsin-Chu Branch ( Site 0511), Hsinchu, Not set
Hualien Tzu Chi Medical Center-Hospital ( Site 0510), Hualien, Not set
Kaohsiung Chang Gung Memorial Hospital ( Site 0507), Kaohsiung, Not set
Taipei Medical University Shuang Ho Hospital ( Site 0508), New Taipei, Not set
China Medical University Hospital ( Site 0505), Taichung, Not set
Taichung Veterans General Hospital ( Site 0504), Taichung, Not set
National Cheng Kung University Hospital ( Site 0506), Tainan, Not set
National Taiwan University Hospital ( Site 0500), Taipei, Not set
Mackay Memorial Hospital ( Site 0503), Taipei, Not set
Taipei Veterans General Hospital ( Site 0501), Taipei, Not set
Chang Gung Medical Foundation. Linkou ( Site 0502), Taoyuan, Not set
Sussex University Hospitals ( Site 1003), Brighton, Brighton And Hove
Western General Hospital ( Site 1009), Edinburgh, Edinburgh, City Of
Leicester Royal Infirmary ( Site 1000), Leicester, Leicestershire
University College London Hospitals NHS Foundation Trust ( Site 1006), London, London, City Of
Chelsea & Westminster Hospital ( Site 1001), London, London, City Of
Birmingham Heartlands Hospital ( Site 1002), Birmingham, Not set
St James s University Hospital ( Site 1008), Leeds, Not set
Barking Havering and Redbridge University Hospitals NHS Trust Queen s Hospital ( Site 1004), Romford, Not set
Conditions: Non-small Cell Lung Cancer
Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Participants With Untreated Inoperable or Metastatic Urothelial Cancer
Active Not Recruiting
The purpose of this study is to determine whether an investigational immunotherapy nivolumab in combination with ipilimumab or in combination with standard of care chemotherapy is more effective than standard of care chemotherapy alone in treating participants with previously untreated inoperable or metastatic urothelial cancer.
The purpose of this study is to determine whether an investigational immunotherapy nivolumab in combination with ipilimumab or in combination with standard of care chemotherapy is more effective than standard of care chemotherapy alone in treating participants with previously untreated inoperable or metastatic urothelial cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2024
Locations: Local Institution - 0001, Anchorage, Alaska +173 locations
Local Institution - 0001, Anchorage, Alaska
Local Institution - 0115, Fresno, California
St Joseph Heritage Healthcare, Santa Rosa, California
Local Institution - 0051, Boca Raton, Florida
Local Institution - 0087, Fort Lauderdale, Florida
Local Institution - 0062, Jacksonville, Florida
Local Institution - 0004, Athens, Georgia
Local Institution - 0033, Thomasville, Georgia
Local Institution - 0046, Chicago, Illinois
Local Institution - 0117, New Orleans, Louisiana
Local Institution - 0056, Boston, Massachusetts
Local Institution - 0073, Boston, Massachusetts
Local Institution - 0208, Boston, Massachusetts
Local Institution - 0207, Milford, Massachusetts
Local Institution - 0063, Ann Arbor, Michigan
Local Institution - 0002, Burnsville, Minnesota
Hattiesburg Clinic, Hattiesburg, Mississippi
Local Institution - 0032, Kansas City, Missouri
Local Institution - 0095, Saint Louis, Missouri
Local Institution - 0057, Manchester, New Hampshire
Local Institution - 0084, Albuquerque, New Mexico
Local Institution - 0083, Buffalo, New York
Local Institution - 0014, Mineola, New York
Local Institution - 0072, New York, New York
Local Institution - 0116, Durham, North Carolina
Local Institution - 0082, Columbus, Ohio
Local Institution - 0104, Portland, Oregon
Local Institution - 0013, Pittsburgh, Pennsylvania
Local Institution - 0086, Kirkland, Washington
Local Institution - 0005, Capital Federal, Buenos Aires
Local Institution - 0007, Mar Del Plata, Buenos Aires
Local Institution - 0008, Viedma, RIO Negro
Local Institution - 0009, Buenos Aires, Not set
Local Institution - 0134, Cordoba, Not set
Local Institution - 0006, Cordoba, Not set
Local Institution - 0096, Waratah, New South Wales
Local Institution - 0099, Westmead, New South Wales
Local Institution - 0188, South Brisbane, Queensland
Local Institution - 0120, Tugun, Queensland
Local Institution - 0101, Heidelberg, Victoria
Local Institution - 0100, Doubleview, Western Australia
Local Institution - 0017, Brasilia, Distrito Federal
Local Institution - 0021, Ijui, RIO Grande DO SUL
Local Institution - 0119, Passo Fundo, RIO Grande DO SUL
Local Institution - 0020, Porto Alegre, RIO Grande DO SUL
Local Institution - 0016, Florianopolis, Santa Catarina
Local Institution - 0018, Barretos, Sao Paulo
Local Institution - 0019, Sao Jose Do Rio Preto, Sao Paulo
Local Institution - 0053, Halifax, Nova Scotia
Local Institution - 0064, London, Ontario
Local Institution - 0054, Quebec City, Quebec
Local Institution - 0052, Sherbrooke, Quebec
Local Institution - 0010, Santiago, Metropolitana
Local Institution - 0012, Vina del Mar, Valparaiso
Local Institution - 0106, Vitacura, Not set
Local Institution - 0171, Beijing, Beijing
Local Institution - 0169, Beijing, Beijing
Local Institution - 0182, Chongqing, Chongqing
Local Institution - 0217, Guiyang, Guizhou
Local Institution - 0219, Harbin, Heilongjiang
Local Institution - 0180, Wuhan, Hubei
Local Institution - 0177, Nanjing, Jiangsu
Local Institution - 0176, Nanjing, Jiangsu
Local Institution - 0175, Nanjng, Jiangsu
Local Institution - 0186, Changchun, Jilin
Local Institution - 0220, Taiyuan, Shan1xi
Local Institution - 0216, Yantai, Shandong
Local Institution - 0167, Shanghai, Shanghai
Local Institution - 0162, Shanghai, Shanghai
Local Institution - 0163, Shanghai, Shanghai
Local Institution - 0184, Chengdu, Sichuan
Local Institution - 0173, Hangzhou, Zhejiang
Local Institution - 0174, Hangzhou, Zhejiang
Local Institution - 0172, Hangzhou, Zhejiang
Local Institution - 0170, Beijing, Not set
Local Institution - 0164, Shanghai, Not set
Local Institution - 0160, Brno, Not set
Local Institution - 0152, Hradec Kralove, Not set
Local Institution - 0190, Aalborg, Not set
Local Institution - 0196, Herlev, Not set
Local Institution - 0060, Helsinki, Not set
Local Institution - 0091, Nîmes, Gard
Local Institution - 0089, Lille, Not set
Local Institution - 0088, Marseille Cedex 9, Not set
Local Institution - 0090, St Priest En Jarez, Not set
Local Institution - 0092, Suresnes, Not set
Local Institution - 0093, Tours Cedex, Not set
Local Institution - 0094, Villejuif, Not set
Local Institution - 0036, Dresden, Not set
Local Institution - 0048, Essen, Not set
Local Institution - 0047, Freiburg, Not set
Local Institution - 0049, Hamburg, Not set
Local Institution - 0037, Hannover, Not set
Local Institution - 0041, Jena, Not set
Local Institution - 0213, Mannheim, Not set
Local Institution - 0038, Nuernberg, Not set
Local Institution - 0040, Tuebingen, Not set
Local Institution - 0114, Weiden, Not set
Local Institution - 0039, Wuerzburg, Not set
Local Institution - 0102, Athens, Not set
Local Institution - 0103, Ioannina, Ípeiros
Local Institution - 0199, Kfar Saba, Not set
Local Institution - 0198, Ramat Gan, Not set
Local Institution - 0108, Arezzo, Not set
Local Institution - 0197, Faenza, Not set
Local Institution - 0111, Forlì, Not set
Local Institution - 0109, Grosseto, Not set
Local Institution - 0107, Milano, Not set
Local Institution - 0110, Napoli, Not set
Local Institution - 0136, Hirosaki, Aomori
Local Institution - 0135, Chiba-shi, Chiba
Local Institution - 0147, Matsuyama-shi, Ehime
Local Institution - 0140, Fukuoka-shi, Fukuoka
Local Institution - 0146, Sapporo-city, Hokkaido
Local Institution - 0150, Tsukuba-shi, Ibaraki
Local Institution - 0214, Morioka-shi, Iwate
Local Institution - 0137, Kita-Gun, Kagawa
Local Institution - 0141, Niigata-shi, Niigata
Local Institution - 0143, Okayama-shi, Okayama
Local Institution - 0144, Osaka-shi, Osaka
Local Institution - 0139, Osakasayama, Osaka
Local Institution - 0145, Takatsuki-shi, Osaka
Local Institution - 0201, Hamamatasu, Shizuoka
Local Institution - 0149, Adachi-ku, Tokyo
Local Institution - 0148, Bunkyo-ku, Tokyo
Local Institution - 0142, Bunkyo-ku, Tokyo
Local Institution - 0138, Shinjuku-Ku, Tokyo
Local Institution - 0215, Wakayama-shi, Wakayama
Local Institution - 0200, Ube City, Yamaguchi
Local Institution - 0125, Goyang-si, Gyeonggido
Local Institution - 0126, Seongnam-si, Not set
Local Institution - 0124, Seoul, Not set
Local Institution - 0151, Seoul, Not set
Local Institution - 0128, Seoul, Not set
Local Institution - 0127, Seoul, Not set
Local Institution - 0129, Ciudad de Mexico, Distrito Federal
Local Institution - 0154, Mexico City, Distrito Federal
Local Institution - 0130, Tlalpan, Distrito Federal
Local Institution - 0131, Monterrey, Nuevo Leon
Local Institution - 0022, Amsterdam, Noord-Holland
Local Institution - 0055, Enschede, Not set
Local Institution - 0024, Groningen, Not set
Local Institution - 0026, Leeuwarden, Not set
Local Institution - 0074, Bergen, Not set
Local Institution - 0081, Lorenskog, Not set
Local Institution - 0030, Lima, Not set
Local Institution - 0031, Lima, Not set
Local Institution - 0189, Bydgoszcz, Not set
Local Institution - 0205, Koszalin, Not set
Local Institution - 0202, Warszawa, Not set
Local Institution - 0191, Cluj-Napoca, Cluj
Local Institution - 0187, Craiova, Dolj
Local Institution, Moscow, Not set
Local Institution - 0192, Singapore, Central Singapore
Local Institution - 0070, A Coruna, Not set
Local Institution - 0068, Barcelona, Not set
Local Institution - 0065, Madrid, Not set
Local Institution - 0066, Madrid, Not set
Local Institution - 0209, Santander, Not set
Local Institution - 0067, Sevilla, Not set
Local Institution - 0069, Valencia, Not set
Local Institution - 0075, Jonkoping, Not set
Local Institution - 0059, Linkoping, Not set
Local Institution - 0058, Lund, Not set
Local Institution - 0061, Baden, Aargau
Local Institution - 0042, Chur, Not set
Local Institution - 0156, Kaohsiung, Not set
Local Institution - 0159, Taichung, Not set
Local Institution - 0158, Taipei, Not set
Local Institution - 0155, Taipei, Not set
Local Institution - 0157, Taoyuan, Not set
Local Institution - 0194, Ankara, Not set
Local Institution - 0204, Istanbul, Not set
Local Institution - 0193, Izmir, Not set
Conditions: Urothelial Cancer
Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)
Active Not Recruiting
The goal of this clinical study is to learn more about the study drug, sacituzumab govitecan-hziy (SG), and its dosing in combination with pembrolizumab or pembrolizumab and a platinum agent (carboplatin or cisplatin), in participants with advanced or metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC).
The goal of this clinical study is to learn more about the study drug, sacituzumab govitecan-hziy (SG), and its dosing in combination with pembrolizumab or pembrolizumab and a platinum agent (carboplatin or cisplatin), in participants with advanced or metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: Alaska Oncology and Hematology, LLC., Anchorage, Alaska +100 locations
Alaska Oncology and Hematology, LLC., Anchorage, Alaska
Beverly Hills Cancer Center, Beverly Hills, California
USC/Norris Comprehensive Cancer Center, Los Angeles, California
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California
UC Irvine Health, Orange, California
Stanford Cancer Institute, Stanford, California
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora, Colorado
Georgetown University Medical Center, Washington, District of Columbia
Moffitt Cancer Center, Tampa, Florida
Northside Hospital Central Research Department, Atlanta, Georgia
Northwestern Memorial Hospital, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
Orchard Healthcare Research Inc., Skokie, Illinois
Kansas City Veterans Affairs Medical Center, Westwood, Kansas
Kansas City VA Medical Center, Kansas City, Missouri
Weill Cornell Medical/New York-Presbyterian Hospital, New York, New York
Great Lakes Cancer Care, Williamsville, New York
Wake Forest Baptist Health - High Point Medical Center, High Point, North Carolina
FirstHealth Outpatient Cancer Center, Pinehurst, North Carolina
University Hospital Cleveland Medical Center, Cleveland, Ohio
OSU Brain & Spine Hospital, Columbus, Ohio
Siouxland Regional Cancer Center dba June E. Nylen Cancer Center, North Sioux City, South Dakota
Southern Highlands Cancer Centre, Bowral, New South Wales
Saint Vincents Hospital Sydney, Darlinghurst, New South Wales
St George Private Hospital, Kogarah, New South Wales
Pindara Private Hospital, Benowa, Queensland
Sunshine Coast University Private Hospital, Birtinya, Queensland
Flinders Medical Centre, Bedford Park, South Australia
Ashford Cancer Centre Research, Windsor Gardens, South Australia
Peninsula Health - Frankston Hospital, Frankston, Victoria
Western Health - Sunshine Hospital, Melbourne, Victoria
Joondalup Health Campus, Joondalup, Western Australia
CIUSSS Saguenay Lac St-Jean, Quebec, Not set
McGill University Health Centre, Quebec, Not set
APHP - Hôpital Ambroise Paré, Boulogne-Billancourt, Not set
CHRU de Brest - Hopital Morvan, Brest, Not set
Centre Francois Baclesse, Caen, Not set
CHU de CAEN, Caen, Not set
Centre Jean Perrin - 58 rue Montalembert, Clermont-Ferrand, Not set
Centre Georges-François Leclerc, Dijon, Not set
Clinique Victor Hugo, Le Mans, Not set
Institut Curie, Paris, Not set
CHU de Bordeaux Hopital Haut leveque, Pessac, Not set
Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre Benite, Not set
Institut de Cancérologie de l'Ouest, Saint Herblain, Not set
Evangelische Lungenklinik Berlin Krakenhausbetriebs GmBH, Berlin, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
Universitatsklinikum Koln, Klinik I fur Innere Medizin, Cologne, Not set
Klinikum Esslingen GmbH, Klinik fur Kardiologie, Angiologie und Pneumologie, Esslingen, Not set
Universitatsklinikum Frankfurt, Frankfurt, Not set
Asklepios Fachkliniken Munchen-Gauting, Zentrum fur Pneumologie und Thoraxchirugie, Gauting, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Martha-Maria Krankenhaus Halle Dölau gGmbH, Halle, Not set
LKI Lungenfachklinik Immenhausen, Immenhausen, Not set
Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Not set
Queen Elizabeth Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Hong Kong United Oncology Center, Kowloon, Not set
ASST Spedali Civili di Brescia, Brescia, Not set
AOU Policlinico Vittorio Emanuele - POG Rodolico, Catania, Not set
Azienda Ospedaliero-Universitaria di Parma, Parma, Not set
IRCCS Istituti Fisioterapicic Ospitalieri - Istituto Nazionale Tumori Regina Elena, Rome, Not set
IRCCS Instituto Clinico Humanitas, Rozzano, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Gachon University Gil Medical Center, Inchon, Not set
Asan Medical Center, Seoul, Not set
Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
The Catholic University of Korea St. Vincent's Hospital, Suwon, Not set
Sultan Ismail Hospital, Johor Bahru, Not set
Hospital Raja Perempuan Zainab II, Kota Bharu, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Hospital Tengku Ampuan Afzan, Kuantan, Not set
Sarawak General Hospital, Kuching, Not set
Institut Kanser Negara, Putrajaya, Not set
Complejo Hospitalario Universitario A Coruna. Hospital Teresa Herrera, A coruna, Not set
Hospital Universitari Germans Trias i Pujol, Badalona, Not set
Hospital Universitari Vall d'Hebrón, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital Duran i Reynals, Barcelona, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Not set
Clinica Universidad de Navarra - Pamplona, Pamplona, Not set
Hospital Regional Universitario de Malaga-Hospital Civil, Rincon de la Victoria, Not set
Complejo Hospitalario Universitario de Santiago de Compostela CHUS_Hospital Clinico Universitario, Santiago de Compostela, Not set
Hospital Universitario Virgen de Valme, Sevilla, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitari i Politecnic La Fe, Valencia, Not set
Changhua Christian Hospital, Changhua City, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Not set
E-DA Hospital, Kaohsiung City, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Chi Mei Hospital - Liouying, Liouying Dist., Not set
National Cheng Kung University Hospital, Tainan City, Not set
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei City, Not set
National Taiwan University Hospital, Taipei City, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital (CGMH), Taoyuan City, Not set
University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set
Guy's and St Thomas' NHS Foundation Trust, London, Not set
Conditions: Non-small Cell Lung Cancer
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma
Active Not Recruiting
The primary aim of this randomized phase III trial was to study whether the addition of maintenance chemotherapy delivered after surgical resection and focal radiation would be better than surgery and focal radiation alone. The trial also studied if patients who received induction chemotherapy and then either achieved a complete response or went on to have a complete resection would also benefit from maintenance chemotherapy. Children ages 1-21 years with newly diagnosed intracranial ependymoma... Read More
The primary aim of this randomized phase III trial was to study whether the addition of maintenance chemotherapy delivered after surgical resection and focal radiation would be better than surgery and focal radiation alone. The trial also studied if patients who received induction chemotherapy and then either achieved a complete response or went on to have a complete resection would also benefit from maintenance chemotherapy. Children ages 1-21 years with newly diagnosed intracranial ependymoma were included. There were 2 arms that were not randomized. One arm studied patients with Grade II tumors located in the supratentorial compartment that were completely resected. One arm studied patients with residual tumor and those patients all received maintenance chemotherapy after focal radiation. Chemotherapy drugs, such as vincristine sulfate, carboplatin, cyclophosphamide, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Giving chemotherapy in combination with radiation therapy may kill more tumor cells and allow doctors to save the part of the body where the cancer started. Read Less
Gender:
ALL
Ages:
Between 12 months and 21 years
Trial Updated:
10/16/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama +208 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Lee Memorial Health System, Fort Myers, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Hospital, West Palm Beach, Florida
Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Tulane University Health Sciences Center, New Orleans, Louisiana
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Ascension Saint John Hospital, Detroit, Michigan
Michigan State University Clinical Center, East Lansing, Michigan
Hurley Medical Center, Flint, Michigan
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Columbia Regional, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Overlook Hospital, Summit, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Winthrop Hospital, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
Mercy Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Greenville Cancer Treatment Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Royal Brisbane and Women's Hospital, Herston, Queensland
Royal Children's Hospital-Brisbane, Herston, Queensland
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Monash Medical Center-Clayton Campus, Clayton, Victoria
Royal Children's Hospital, Parkville, Victoria
Princess Margaret Hospital for Children, Perth, Western Australia
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
Conditions: Anaplastic Ependymoma, Brain Ependymoma, Cellular Ependymoma, Clear Cell Ependymoma, Ependymoma, Papillary Ependymoma
First-line Esophageal Carcinoma Study With Pembrolizumab Plus Chemo vs. Chemo (MK-3475-590/KEYNOTE-590)
Completed
The purpose of this trial is to evaluate efficacy and safety of pembrolizumab plus standard of care (SOC) chemotherapy with cisplatin and 5-fluorouracil (5-FU) versus placebo plus SOC chemotherapy with cisplatin and 5-FU as first-line treatment in participants with locally advanced or metastatic esophageal carcinoma.
The overall primary efficacy hypotheses are as follows:
1. In participants with esophageal squamous cell carcinoma (ESCC), participants whose tumors are programmed cell death-liga... Read More
The purpose of this trial is to evaluate efficacy and safety of pembrolizumab plus standard of care (SOC) chemotherapy with cisplatin and 5-fluorouracil (5-FU) versus placebo plus SOC chemotherapy with cisplatin and 5-FU as first-line treatment in participants with locally advanced or metastatic esophageal carcinoma.
The overall primary efficacy hypotheses are as follows:
1. In participants with esophageal squamous cell carcinoma (ESCC), participants whose tumors are programmed cell death-ligand 1 (PD-L1)-positive (defined as combined positive score \[CPS\] ≥10), ESCC participants whose tumors are PD-L1 positive (CPS ≥10), and in all participants, overall survival (OS) is superior with pembrolizumab plus SOC chemotherapy compared with placebo plus SOC chemotherapy.
2. In participants with ESCC, participants whose tumors are PD-L1 positive (CPS ≥10), and in all participants, progression-free survival (PFS) according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by investigator is superior with pembrolizumab plus SOC chemotherapy compared with placebo plus SOC chemotherapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: Kaiser Permanente Southern California ( Site 0003), West Los Angeles, California +188 locations
Kaiser Permanente Southern California ( Site 0003), West Los Angeles, California
The University of Chicago Medical Center ( Site 0001), Chicago, Illinois
University of Kansas ( Site 0029), Westwood, Kansas
University of Maryland Medical Center ( Site 0013), Baltimore, Maryland
Dana Farber Cancer Center ( Site 0009), Boston, Massachusetts
Henry Ford Cancer Center ( Site 0018), Detroit, Michigan
Washington University School of Medicine ( Site 0031), Saint Louis, Missouri
Roswell Park Cancer Institute ( Site 0004), Buffalo, New York
Weill Cornell Medical College ( Site 0024), New York, New York
University Hospitals Cleveland Medical Center ( Site 0002), Cleveland, Ohio
UPMC Cancer Center/Hillman Cancer Center ( Site 0015), Pittsburgh, Pennsylvania
University of Tennessee Medical Center Knoxville ( Site 0017), Knoxville, Tennessee
Centro de Investigaciones Clinicas - Clinica Viedma ( Site 0603), Viedma, Rio Negro
Hospital Aleman ( Site 0605), Buenos Aires, Not set
Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0602), Buenos Aires, Not set
Sanatorio Allende - Cordoba ( Site 0604), Cordoba, Not set
Hospital Privado Centro Medico Cordoba ( Site 0601), Cordoba, Not set
Blacktown Hospital ( Site 2000), Blacktown, New South Wales
Liverpool Hospital. ( Site 2001), Liverpool, New South Wales
Princess Alexandra Hospital ( Site 2005), Woolloongabba, Queensland
Eastern Health ( Site 2002), Box Hill, Victoria
Peter MacCallum Cancer Centre ( Site 2003), Melbourne, Victoria
CETUS Hospital Dia Oncologia ( Site 0208), Belo Horizonte, Minas Gerais
Inst de Medicina Integral Professor Fernando Figueira- IMIP ( Site 0210), Recife, Pernambuco
Clinica de Hematologia e Oncologia Viver Ltda ( Site 0211), Santa Maria, Rio Grande Do Sul
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0209), Rio de Janeiro, RJ
Hospital Sao Vicente de Paulo ( Site 0204), Passo Fundo, RS
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0201), Porto Alegre, RS
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto. ( Site 0203), Sao Jose do Rio Preto, Sao Paulo
Hospital Alemao Oswaldo Cruz ( Site 0207), Sao Paulo, SP
Hospital de Clinicas de Porto Alegre ( Site 0200), Porto Alegre, Not set
Instituto do Cancer de Sao Paulo - ICESP ( Site 0206), Sao Paulo, Not set
Tom Baker Cancer Centre ( Site 0503), Calgary, Alberta
Cross Cancer Institute ( Site 0502), Edmonton, Alberta
CancerCare Manitoba ( Site 0500), Winnipeg, Manitoba
Juravinski Cancer Center ( Site 0508), Hamilton, Ontario
The Ottawa Hospital - Cancer Care ( Site 0501), Ottawa, Ontario
Princess Margaret Cancer Centre ( Site 0505), Toronto, Ontario
CISSS de la Monteregie-Centre ( Site 0504), Greenfield Park, Quebec
Jewish General Hospital ( Site 0507), Montreal, Quebec
Hospital Regional de Concepcion Dr. Guillermo Grant Benavente ( Site 1003), Concepcion, Not set
Pontificia Universidad Catolica de Chile ( Site 1001), Santiago, Not set
Hospital Clinico Universidad de Chile ( Site 1002), Santiago, Not set
Clinica Alemana de Temuco ( Site 1006), Temuco, Not set
Anhui Provincial Hospital ( Site 0106), Hefei, Anhui
The First Affiliated Hospital of Anhui Medical University ( Site 0112), Hefei, Anhui
Peking Union Medical College Hospital ( Site 0123), Beijing, Beijing
The First Affiliated Hospital of Xiamen University ( Site 0119), Xiamen, Fujian
Guangdong General Hospital ( Site 0103), Guangzhou, Guangdong
The Affiliated Tumour Hospital of Harbin Medical University ( Site 0102), Harbin, Heilongjiang
Tongji Medical College Huazhong University of Science and Technology ( Site 0109), Wuhan, Hubei
Hunan Cancer Hospital ( Site 0105), Changsha, Hunan
PLA Cancer Centre of Nanjing Bayi Hospital ( Site 0110), Nanjing, Jiangsu
Zhongda Hospital Southeast University ( Site 0125), Nanjing, Jiangsu
Jilin Cancer Hospital ( Site 0101), Changchun, Jilin
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0120), Xi'an, Shannxi
Zhejiang Cancer Hospital ( Site 0116), Hangzhou, Zhejiang
Beijing Cancer Hospital ( Site 0100), Beijing, Not set
Fujian Provincial Cancer Hospital ( Site 0104), Fuzhou, Not set
Shanghai Chest Hospital ( Site 0111), Shanghai, Not set
Fudan University Shanghai Cancer Center ( Site 0108), Shanghai, Not set
Renji Hospital Shanghai Jiaotong University School of Medicine ( Site 0114), Shanghai, Not set
Henan Cancer Hospital ( Site 0107), Zhengzhou, Not set
Rodrigo Botero SAS ( Site 2703), Medellin, Antioquia
Oncomedica S.A. ( Site 2701), Monteria, Cordoba
CIMCA Centro de Investigacion y Manejo del Cancer ( Site 2600), San Jose, Not set
Policlinico San Bosco ( Site 2602), San Jose, Not set
ICIMED - Instituto de Investigacion en Ciencias Medicas ( Site 2601), San Jose, Not set
Rigshospitalet ( Site 2301), Copenhagen, Not set
Odense Universitetshospital ( Site 2300), Odense, Not set
Centre Leon Berard ( Site 0307), Lyon, Cedex 8
CHU Brest - Institut de Cancerologie et d Hematologie ( Site 0305), Brest, Not set
Centre Francois Baclesse ( Site 0310), Caen, Not set
Centre Oscar Lambret ( Site 0304), Lille, Not set
Institut du Cancer de Montpellier ( Site 0306), Montpellier, Not set
CHU de Nantes - Hotel Dieu ( Site 0303), Nantes Cedex 1, Not set
Institut Mutualiste Montsouris ( Site 0300), Paris, Not set
CHU de Saint Etienne Hopital Nord ( Site 0309), Saint Etienne, Not set
Staedtisches Klinikum Dresden ( Site 1507), Dresden, Not set
Haematologisch-Onkologische Praxis Eppendorf Facharztzentrum Eppendorf - Hope ( Site 1502), Hamburg, Not set
Universitaetsklinikum Leipzig ( Site 1501), Leipzig, Not set
Klinikum Ludwigsburg ( Site 1509), Ludwigsburg, Not set
Universitatsklinikum Mannheim GmbH ( Site 1504), Mannheim, Not set
Klinik fuer Haematologie. Onkologie und Gastroenterologie ( Site 1508), Moenchengladbach, Not set
III. Medizinische Klinik Klinikum rechts der Isar ( Site 1506), Munchen, Not set
Centro de Investigacion Oncologica ( Site 1402), Guatemala, Not set
Oncomedica ( Site 1400), Guatemala, Not set
Grupo Medico Angeles ( Site 1401), Guatemala, Not set
Medi-K Cayala ( Site 1404), Guatemala, Not set
Centro Regional de Sub Especialidades Medicas SA ( Site 1403), Quetzaltenango, Not set
Humanity Health Research Centre ( Site 1603), Hong Kong, Not set
Pamela Youde Nethersole Eastern Hospital ( Site 1601), Hong Kong, Not set
Princess Margaret Hospital. ( Site 1602), Hong Kong, Not set
Queen Mary Hospital ( Site 1600), Hong Kong, Not set
Aichi Cancer Center Hospital ( Site 0902), Nagoya, Aichi
National Cancer Center Hospital East ( Site 0908), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 0901), Matsuyama, Ehime
Hokkaido University Hospital ( Site 0916), Sapporo, Hokkaido
Hyogo Cancer Center ( Site 0913), Akashi, Hyogo
Kobe City Medical Center General Hospital ( Site 0929), Kobe, Hyogo
Ibaraki Prefectural Central Hospital ( Site 0918), Kasama, Ibaraki
University of Tsukuba Hospital ( Site 0910), Tsukuba, Ibaraki
Kagawa University Hospital ( Site 0915), Kita-gun, Kagawa
St. Marianna University School of Medicine Hospital ( Site 0903), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 0921), Yokohama, Kanagawa
Oita University Hospital ( Site 0930), Yufu, Oita
Kansai Medical University Hospital ( Site 0931), Hirakata, Osaka
Kindai University Hospital ( Site 0917), Osakasayama, Osaka
Osaka University Hospital ( Site 0911), Suita, Osaka
Osaka Medical College Hospital ( Site 0925), Takatsuki, Osaka
Saitama Cancer Center ( Site 0926), Kitaadachi-gun, Saitama
Shizuoka Cancer Center Hospital and Research Institute ( Site 0914), Sunto-gun, Shizuoka
Kyorin University Hospital ( Site 0905), Mitaka, Tokyo
Chiba University Hospital ( Site 0909), Chiba, Not set
Chiba Cancer Center ( Site 0900), Chiba, Not set
National Hospital Organization Kyushu Cancer Center ( Site 0906), Fukuoka, Not set
Kyushu University Hospital ( Site 0922), Fukuoka, Not set
Gifu University Hospital ( Site 0920), Gifu, Not set
Kumamoto University Hospital ( Site 0919), Kumamoto, Not set
Niigata Cancer Center Hospital ( Site 0924), Niigata, Not set
Osaka International Cancer Institute ( Site 0923), Osaka, Not set
Osaka General Medical Center ( Site 0912), Osaka, Not set
National Cancer Center Hospital ( Site 0907), Tokyo, Not set
The Cancer Institute Hospital of JFCR ( Site 0904), Tokyo, Not set
Keio University Hospital ( Site 0927), Tokyo, Not set
National Cancer Center ( Site 1304), Goyang-si, Gyeonggi-do
Chonnam National University Hwasun Hospital ( Site 1305), Hwasun Gun, Jeollanam Do
Seoul National University Cancer Hospital ( Site 1301), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 1302), Seoul, Not set
Asan Medical Center ( Site 1303), Seoul, Not set
Samsung Medical Center ( Site 1300), Seoul, Not set
Beacon International Specialist Centre ( Site 1803), Petaling Jaya, Selangor
Hospital Kuala Lumpur ( Site 1805), Kuala Lumpur, Not set
University Malaya Medical Centre ( Site 1802), Kuala Lumpur, Not set
Instituto Regional de Enfermedades Neoplasicas del Sur IRENSUR ( Site 1702), Arequipa, Not set
Hospital Nacional Guillermo Almenara Irigoyen ( Site 1701), Lima, Not set
Instituto Nacional de Enfermedades Neoplasicas ( Site 1705), Lima, Not set
S C Pelican Impex SRL ( Site 2403), Oradea, Bihor
S.C. Radiotherapy Center Cluj S.R.L ( Site 2407), Comuna Floresti, Cluj
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2404), Craiova, Dolj
S.C.Focus Lab Plus S.R.L ( Site 2401), Bucuresti, Sector 2
S C Oncocenter Oncologie Medicala S R L ( Site 2405), Timisoara, Timis
S.C.Gral Medical S.R.L ( Site 2406), Bucuresti, Not set
Spitalul Clinic Judetean De Urgenta Constanta ( Site 2402), Constanta, Not set
SBHCI RCOD of MHC RB ( Site 0407), Ufa, Republic Of Bashkortostan
Leningrad Regional Oncology Center ( Site 0405), Saint-Petersburg, Vsevolzhsk District
National Medical and Surgical Center n.a. N.I.Pirogov ( Site 0402), Moscow, Not set
N.N. Blokhin NMRCO ( Site 0401), Moscow, Not set
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0406), Saint-Petersburg, Not set
St Petersburg City Clinical Oncology Dispensary ( Site 0409), St. Petersburg, Not set
Tomsk Scientific Research Institute of Oncology ( Site 0403), Tomsk, Not set
Cancer Care Langenhoven Drive Oncology Centre ( Site 2501), Port Elizabeth, Eastern Cape
The Medical Oncology Centre of Rosebank ( Site 2506), Johannesburg, Gauteng
WITS Clinical Research CMJAH Clinical Trial Site ( Site 2500), Parktown, Gauteng
The Oncology Centre ( Site 2502), Durban, Kwa-Zulu Natal
Cape Town Oncology Trials Pty Ltd ( Site 2508), Cape Town, Western Cape
Outeniqua Cancercare Oncology Unit ( Site 2504), George, Western Cape
Clinton Oncology Centre ( Site 2505), Alberton, Not set
Hospital Universitario Central de Asturias ( Site 0708), Oviedo, Asturias
Hosp. Gral. Universitari Germans Trias i Pujol ( Site 0701), Badalona, Barcelona
Hospital Universitari Vall d Hebron ( Site 0702), Barcelona, Not set
Hospital Universitario Reina Sofia ( Site 0706), Cordoba, Not set
Hospital Ramon y Cajal ( Site 0703), Madrid, Not set
Hospital Universitario La Paz ( Site 0700), Madrid, Not set
Complejo Hospitalario Virgen De La Victoria ( Site 0705), Malaga, Not set
Chang Gung Med Foundation. Kaohsiung Branch ( Site 1906), Kaohsiung, Not set
Taipei Medical University Shuang Ho Hospital ( Site 1908), New Taipei, Not set
China Medical University Hospital ( Site 1904), Taichung, Not set
Kuang Tien General Hospital ( Site 1909), Taichung, Not set
National Cheng Kung University Hospital ( Site 1905), Tainan, Not set
Chi Mei Medical Center Liuying ( Site 1907), Tainan, Not set
National Taiwan University Hospital ( Site 1900), Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center ( Site 1902), Taipei, Not set
Chang Gung Medical Foundation. Linkou ( Site 1903), Taoyuan, Not set
Bumrungrad International Hospital ( Site 2203), Bangkok, Not set
Chulalongkorn Hospital ( Site 2201), Bangkok, Not set
Ramathibodi Hospital. ( Site 2202), Bangkok, Not set
Phramongkutklao Hospital ( Site 2205), Bangkok, Not set
Songklanagarind Hospital ( Site 2204), Songkla, Not set
Adana Sehir Hastanesi ( Site 0802), Adana, Not set
Ankara Sehir Hastanesi ( Site 0808), Ankara, Not set
Istanbul Medeniyet Universitesi Goztepe EAH ( Site 0807), Istanbul, Not set
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0804), Istanbul, Not set
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0801), Istanbul, Not set
Medical Park Izmir Hastanesi ( Site 0800), Izmir, Not set
Inonu Universitesi Turgut Ozal Tip Merkezi ( Site 0803), Malatya, Not set
Lothian University Hospitals NHS Trust ( Site 1101), Edinburgh, Mid Lothian
St Luke's Cancer Centre ( Site 1102), Guildford, Not set
The Christie NHS Foundation Trust ( Site 1100), Manchester, Not set
Conditions: Esophageal Neoplasms
A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)
Terminated
The primary objective of the study is to demonstrate superior efficacy of Xevinapant (Debio 1143) vs placebo when added to chemoradiotherapy (CRT) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN).
The primary objective of the study is to demonstrate superior efficacy of Xevinapant (Debio 1143) vs placebo when added to chemoradiotherapy (CRT) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/29/2024
Locations: The University of Alabama at Birmingham - Hazelrig-Salter Radiation Oncology Center (HSROC), Birmingham, Alabama +287 locations
The University of Alabama at Birmingham - Hazelrig-Salter Radiation Oncology Center (HSROC), Birmingham, Alabama
Banner MD Anderson Cancer Center, Gilbert, Arizona
University of Arizona Cancer Center, Tucson, Arizona
UC San Diego Moores Cancer Center, La Jolla, California
Regents of the University of California, San Francisco, California
UCSF, San Francisco, California
The Oncology Institute of Hope & Innovation, Whittier, California
University of Colorado at Denver and Health Sciences Center, Aurora, Colorado
Yale Cancer Center, New Haven, Connecticut
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia
Moffitt Cancer Center, Tampa, Florida
ASCLEPES Research Centers, Weeki Wachee, Florida
Columbus Regional Research Institute, Columbus, Georgia
IACT Health, John B. Amos Cancer Center, Columbus, Georgia
Inventa Center for Cancer Research At Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana
Ashland-Bellefonte Cancer Center, Ashland, Kentucky
Norton Cancer Institute, Louisville, Kentucky, Brownsboro Hospital Campus, Louisville, Kentucky
Massachusetts General Hospital, Boston, Massachusetts
Beth Israel Deaconess (BI Lahey)/Harvard Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
University South Hospital, Ann Arbor, Michigan
Henry Ford Health System, Detroit, Michigan
Karmanos Cancer institute, Detroit, Michigan
University of Missouri - Ellis Fischel Cancer Center, Columbia, Missouri
MidAmerica Cancer Care, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Comprehensive Cancer Center of Nevada (Southern Hills) (USA), Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
NYU Langone Hospital-Long Island Oncology, Mineola, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York
NYU Grossman School of Medicine, New York, New York
Wake Forest University School of Medicine, Winston-Salem, North Carolina
University of Cincinnati Medical Center, Cincinnati, Ohio
University Hospital Cleveland Medical Center, Cleveland, Ohio
Cleveland Clinic, Cleveland, Ohio
Ohio State University, Columbus, Ohio
University of Oklahoma Health Sciences Center- Stephenson Cancer Center, Oklahoma City, Oklahoma
Providence Portland Medical Center, Portland, Oregon
Gettysburg Cancer Center, Gettysburg, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Medical University of South Carolina- Hollings Cancer Center, Charleston, South Carolina
MD Anderson, Houston, Texas
IHO Corporation/Utah Cancer Specialists, Salt Lake City, Utah
University of Virginia Medical Center, Charlottesville, Virginia
Hospital Aleman, Buenos Aires, Not set
Instituto Medico Especialazado Alexander Fleming, Buenos Aires, Not set
Clinica Universitaria Reina Fabiola, Cordoba, Not set
Instituto de Oncologia de Rosario, Santa Fe, Not set
Clinica Viedma, Viedma, Not set
Ashford Cancer Centre Research, Tennyson Centre, Adelaide, Not set
St Vincents Hospital, Darlinghurst, Not set
St Vincents Hospital Melbourne, Fitzroy, Not set
Peter MacCallum Cancer Centre, Melbourne, Not set
Wollongong Hospital, Wollongong, Not set
Princess Alexandra Hospital, Cancer Trials Unit, Woolloongabba, Not set
Klinische Abteilung fur Allgemeine HNO Universitatsklinik fur Hals-, Nasen- und Ohrenheilkunde, Graz, Not set
Landeskrankenhaus Salzburg, Salzburg, Not set
Universitätsklinik für Innere Medizin III der PMU, Salzburg, Not set
Medical University of Vienna, Department of Medicine I, Division of Oncology, Vienna, Not set
Cliniques universitaires Saint-Luc, Bruxelles, Not set
Grand Hopital de Charleroi, Charleroi, Not set
Universitair Ziekenhuis Antwerpen, Edegem, Not set
Universitair Ziekenhuis Gent UZ Gent, Gent, Not set
Hopital de Jolimont, Rue Ferrer, La Louvière, Not set
UZ Leuven, Radiotherapy & Oncology, Leuven, Not set
Centre Hospitalier de l'Ardenne (CHA), Libramont, Not set
CHU UCL Namur Site Sainte Elisabeth, Namur, Not set
A.Z. Nikolaas, Sint-Niklaas, Not set
GZA Sint-Augustinus, Wilrijk, Not set
Fundação Pio XII- Hospital de Cancer de Barretos, Rua Antenor Duarte Vilela, Barretos, Not set
Hospital de Caridade de Ijui, Avenida David Jose Martins, Ijuí, Not set
Liga Norte Riograndense Contra o Câncer, Avenida Miguel Castro, Natal, Not set
Centro Gaúcho Integrado, Rua Costa, Porto Alegre, Not set
Hospital Santa Rita Centro de Pesquisa Clínica Novos Tratamentos Em Câncer, Porto Alegre, Not set
Hospital Santa Rita, Centro de Pesquisa Clínica Novos Tratamentos Em Câncer, Porto Alegre, Not set
National Cancer Institute, Rio De Janeiro, Not set
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - FMABC - Faculdade de Medicina do ABC, Santo André, Not set
Hospital de Base de Sao Jose do Rio Preto, Av. Brigadeiro Faria Lima, São José Do Rio Preto, Not set
Instituto do Cancer do Estado de Sao Paulo (ICESP), São Paulo, Not set
Oswaldo Cruz German Hospital, São Paulo, Not set
London Regional Cancer Program, London Health Sciences Centre, London, Not set
CHU Montréal, Montreal, Not set
CIUSSS de l'Est de l'Ile de Montreal - Hopital Maisonneuve-Rosemont, Montreal, Not set
Hopital Maisonneuve-Rosemont, Montreal, Not set
CHU de Quebec-Université Laval, Québec, Not set
Sunnybrook Research Institute, Toronto, Not set
Beijing Cancer Hospital, Beijing, Not set
Peking Union Medical College Hospital, Beijing, Not set
Jilin Cancer Hospital, Changchun, Not set
Hunan Cancer Hospital, Changsha, Not set
Xiangya Hospital Central South University, Changsha, Not set
West China Hospital of Sichuan University, Chengdu, Not set
Fujian Cancer Hospital, Fuzhou, Not set
The 5th Affiliated Hospital of Sun yet-sen university, Guangdong, Not set
The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Not set
Zhejiang Province Cancer Hospital, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Not set
Lin Yi Cancer Hospital, Shandong, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Shanghai Ninth People's Hospital, Shanghai, Not set
Shantou University Cancer Hospital, Shantou, Not set
Liaoning Cancer Hospital & institute, Shenyang, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Tongji Hospital/Tongji Medical College, Huazhong University of Science, Wuhan, Not set
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Not set
Henan Cancer Hospital, Zhengzhou, Not set
University Hospital hradec Kralové, Hradec Králové, Not set
Fakultni Nemocnice Ostrava, Ostrava-Poruba, Not set
Hospital Na Bulovce, Prague, Not set
KOC KNTB a.s. Zlín, Zlín, Not set
CHU Amiens Picardie - Hopital Sud, Amiens, Not set
Institut de Cancérologie de l Ouest (ICO), Angers, Not set
Institut Sainte Catherine, Avignon Cedex 9, Not set
Centre hospitalier Universitaire de Bordeaux, Bordeaux, Not set
CHRU de Brest Hopital Morvan, Brest, Not set
Centre Jean Perrin CLCC, Clermont Ferrand, Not set
CHU de Grenoble, Grenoble Cedex 9, Not set
Centre Guillaume Le Conquerant, le Havre, Not set
Clinique Victor Hugo, Le Mans, Not set
Centre hospitalier Libourne, Libourne, Not set
Centre Oscar Lambret, Lille, Not set
Hôpital du Scorff, Lorient, Not set
Centre Leon Berard, Lyon, Not set
Service d'Oncologie Médicale, CHU Timone, Marseille, Not set
Hôpital Nord Franche Comté, Montbeliard, Not set
Institut Regional du Cancer de Montpellier, Montpellier, Not set
LHopital prive du Confluent Nantes, Nantes Cedex 2, Not set
CCConcorde (GCS), Neuilly sur Seine, Not set
Centre Antoine Lacassagne, Nice, Not set
CHU Nimes, Nimes, Not set
Institut Curie, Paris, Not set
Centre Eugène Marquis, Rennes Cedex, Not set
Centre Henri Becquerel CLCC, Rouen Cedex, Not set
CHP Saint Gregoire FINESS, Saint Gregoire, Not set
Institut de Cancérologie de l'Ouest - Site Saint Herblain, Saint Herblain, Not set
ICANS, Strasbourg, Not set
Institut Claudius Regaud - IUCT-O, Toulouse, Not set
CHU de Tours, Tours, Not set
The Public Hospital L'Institut de Cancerologie de Lorraine, Vandoeuvre les Nancy, Not set
Institut Gustave Roussy - Service de radiotherapie, Villejuif, Not set
Evex Hospitals Oncology Center, Kutaisi, Not set
Academician Fridon Todua Medical Center-Ltd Research Institute of Clinical Medicine, Tbilisi, Not set
Cancer Research Cent 4, Tbilisi, Not set
Institute of Clinical Oncology, Tbilisi, Not set
JSC "Evex Hospitals", Tbilisi, Not set
LEPL First University Clinic of Tbilisi State Medical University, Tbilisi, Not set
New Hospitals, Tbilisi, Not set
Simon Khechinashvili University Clinic, Tbilisi, Not set
CAMPUS CHARITÉ MITTE, Klinik f.Strahlentherapie, Berlin, Not set
Charité - Universitätsmedizin Berlin Campus Virchow, Berlin, Not set
Strahlenklinik des Uni-Klinikums, Erlangen, Not set
Department of radiation oncology, University Hospital Essen, Essen, Not set
Univesitätsklinikum Essen (AöR) Klinikum und Poliklinik für Strahlentherapie, Essen, Not set
Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set
Universitaetsklinikum Jena - Klinik fuer Hals - Nasen und Ohrenheilkunde HNO, Jena, Not set
University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Not set
Universitatsklinikum Leipzig AoR, Klinik für Strahlentherapie, Leipzig, Not set
Universitaetsmedizin Mannheim UMM, Klinik fuer Hals-Nasen-Ohrenheilkunde Kopf- und Halschirurgie, Mannheim, Not set
Universitaetsklinikum Regensburg, Regensburg, Not set
Universitaetsmedizin Rostock, Rostock, Not set
Agioi Anargiroi General Oncology Hospital of Kifissia, Athens, Not set
Attikon University Hospital, Athens, Not set
Theagenio Anticancer Hospital, Thessaloníki, Not set
Orszagos Onkologiai Intezet Sugarterapias Osztaly, Budapest, Not set
Uzsoki Utcai Korhaz Onkologiai Osztaly, Budapest, Not set
Petz Aladár Megyei Kórház Onkoradiológiai Osztály, Győr, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intazet, Pécs, Not set
Szegedi Tudományegyetem ÁOK Onkoterápiás Klinika, Szeged, Not set
Rambam Healthcare Campus, Haifa, Not set
Research Fund of the Hadassah Medical Organization, Jerusalem, Not set
Rabin Medical Center, Petach Tiqva, Not set
Sheba Medical Center, Ramat Gan, Not set
Centro di Riferimento Oncologico, Aviano, Not set
Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia, Brescia, Not set
Istituto di Candiolo IRCCS, Candiolo, Not set
Azienda Sanitaria Ospedaliera Santa Croce e Carle - Oncologia Medica -Ospedale Carle, Cuneo, Not set
Azienda Ospedaliero-Universitaria Careggi, Firenze, Not set
IRCCS AOU San Martino, Genova, Not set
Ospedale "Vito Fazzi" Lecce, Lecce, Not set
Az. USL 6 Ospedali Riuniti-Ospedale di Livorno, Livorno, Not set
IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Not set
IRCCS-Istituto Europeodi Oncologia The European Institute of Oncology IEO, Milan, Not set
Istituto Nazionale dei Tumori, Milan, Not set
Policlinico di Modena, Modena, Not set
AORN Ospedale dei Monaldi, Napoli, Not set
AOU "Luigi Vanvitelli", Napoli, Not set
Istituto Nazionale Tumori (INT) IRCCS Fondazione "G. Pascale", Napoli, Not set
Istituto Oncologico Veneto Irccs, Padova, Not set
Azienda Ospedaliero Universitaria di Parma, Parma, Not set
Fondazione Policlinico Universitario Agostino Gemelli, Rome, Not set
ASL2_Presidio Ospedaliero San Paolo, Savona, Not set
National Cancer Center Hospital East, Chiba, Not set
National Cancer Center Hospital, Chuo-ku Tokyo, Not set
Saitama Medical University International Medical Center, Hidaka, Not set
Hyogo Cancer Center, Hyogo, Not set
University Hospital Kyoto Prefectural University of Medicine, Kamigyo-ku, Not set
Tokai University Hospital, Kanagawa, Not set
Hokkaido University Hospital, Kita-Ku, Not set
Okayama University Hospital, Kita-ku, Not set
Kobe University Hospital, Kobe, Not set
Cancer Institute Hospital of JFCR, Koto-ku, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Not set
Shizuoka Cancer Center, Nagaizumi-cho, Not set
Osaka International Cancer Institute, Osaka, Not set
Tokyo Medical University Hospital, Tokyo, Not set
Pusan National University Hospital, Busan, Not set
National Cancer Center Hematologic Oncology, Goyang-si, Not set
National Cancer Center, Goyang-si, Not set
Asan Medical Center, Asian Cacer Center, Seoul, Not set
Asan Medical Center, Seoul, Not set
KonKuk University Medical Center, Seoul, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Boramae Medical Center, Seoul, Not set
Pusan National University Yangsan Hospital, Oncol & Hematology, Yangsan, Not set
Uniwersyteckie Centrum Kliniczne - Klinika Onkologii i Radioterapii, Gdańsk, Not set
Szpitale Pomorskie Sp. z o.o., Gdynia, Not set
Centrum Onkologii- Instytut im. Marii Sklodowskiej-Curie Oddzial w Gliwicach, Gliwice, Not set
SP ZOZ MSWiA z W-M CO w Olsztynie, Olsztyn, Not set
NZOZ Provita Prolife Centrum Medyczne, Łódź, Not set
Centro Clinico Academico, Braga, Not set
Hospital de Braga, Braga, Not set
Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Not set
Centro Hospitalar Universitário do Algarve - Hospital de Faro (PRT), Faro, Not set
Centro Hospitalar Universitário Lisboa Norte, Lissabon, Not set
Centro Hospitalar de Vila Nova de Gaia/Espinho, Porto, Not set
Centro Hospitalar Universitario São João, Porto, Not set
Hospital Pedro Hispano, Porto, Not set
Instituto Portugues de Oncologia Porto Francisco Gentil, E.P.E, Porto, Not set
State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary of the Ministry of Healthcare of the Republic of Tatarstan", Kazan, Not set
Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I.Kryzhanovsky, Krasnoyarsk, Not set
Kursk Regional Clinical Oncology Dispensary, Kursk, Not set
FGBU N.N.Blokhin Russian Cancer Research Center, Moscow, Not set
EuroCityClinic, Saint Petersburg, Not set
Saint- Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology), Saint Petersburg, Not set
FSBI National Med Research Cancer Center N.N. Petrov, Saint-Petersburg, Not set
Republican Clinical Oncological Dispensary of Bashkortostan, Ufa, Not set
State Budgetary Healthcare Institution Republican Clinical Oncology Dispensary (RUS), Ufa, Not set
State Budgetary Institution of Healthcare of Yaroslavl region Clinical oncology hospital, Yaroslavl, Not set
Fundacion Centro Oncologico de Galicia (COG) "Jose Antonio Quiroga y Pineyro", A Coruña, Galicia
Fundacin Oncolgico de Galicia Jos Antonio Quiroga y Pieyro, A Coruna, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Hospital del Mar, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Institut Català d'Oncologia Badalona, Barcelona, Not set
Institut Català d'Oncologia, Hospital Duran, Barcelona, Not set
Institut Universitari Dexeus-Quiron (ESP), Barcelona, Not set
Hospital Reina Sofía, Cordoba, Not set
Institut Català d'Oncologia, Girona, Not set
Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Not set
Clinica Universidad de Navarra, Madrid, Not set
Hospital 12 de Octubre, Madrid, Not set
Hospital Clinico San Carlos, Madrid, Not set
Hospital Ramon y Cajal, Madrid, Not set
Hospital Universitario HM Sanchinarro, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Althaia, Xarxa Assistencial, Manresa, Not set
Fundacio Althaia, Manresa, Not set
Hospital Civil (Hospital Regional Universitario), Málaga, Not set
Clinica Universidad de Navarra, Pamplona, Not set
Hospital Universitario Marqués de Valdecilla. Santander, Santander, Not set
Fundacion Investigacion Hospital General Universitario de Valencia FiHgU (ESP), Valencia, Not set
Hospital Universitario La Fe, Valencia, Not set
IVO, Valencia, Not set
Inselspital, Bern University Hospital, Universitätsklinik für Radio-Onkologie, Bern, Not set
Hopitaux Universitaires de Geneve, Geneve, Not set
Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Not set
Chang-Gung Memorial Hospital-Kaohsiung, Kaohsiung City, Not set
Kaohsiung Medical University Memorial Hospital, Kaohsiung, Not set
Taichung Veterans General Hospital, Taichung City, Not set
China Medical University Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital (VGHTP), Taipei, Not set
Chang Gung Medical Foundatoin Linkou Chang Gung Memorial Hospital, Taoyuan City, Not set
Medical center ASKLEPION LLC, Khodosivka, Not set
Kiev City Clinical Oncology Centre, Kiev, Not set
Medical center of Yuriy Spizhenko, Soborna Vulytsia, Kyiv, Not set
Aberdeen Royal infirmary, Dept. of Oncology, Aberdeen, Not set
Royal Marsden NHS Foundation Trust, Chelsea, Not set
NHS Greater Glasgow and Clyde, Glasgow, Not set
Royal Surrey County Hospital, Guildford, Not set
Charing Cross Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Mount Vernon Cancer Centre, Northwood, Not set
Nottingham University Hospitals NHS Trust, Nottingham, Not set
University Hospital Southampton NHS Foundation Trust, Southampton, Not set
The Royal Marsden NHS Foundation Trust - Sutton, Sutton, Not set
Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, Not set
Conditions: Squamous Cell Carcinoma of the Head and Neck
Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma
Active Not Recruiting
This randomized phase III trial is studying two different combination chemotherapy regimens to compare how well they work in treating young patients with newly diagnosed supratentorial primitive neuroectodermal tumors or high-risk medulloblastoma when given before additional intense chemotherapy followed by peripheral blood stem cell rescue. It is not yet known which combination chemotherapy regimen is more effective when given before a peripheral stem cell transplant in treating supratentorial... Read More
This randomized phase III trial is studying two different combination chemotherapy regimens to compare how well they work in treating young patients with newly diagnosed supratentorial primitive neuroectodermal tumors or high-risk medulloblastoma when given before additional intense chemotherapy followed by peripheral blood stem cell rescue. It is not yet known which combination chemotherapy regimen is more effective when given before a peripheral stem cell transplant in treating supratentorial primitive neuroectodermal tumors or medulloblastoma. Read Less
Gender:
ALL
Ages:
2 years and below
Trial Updated:
09/16/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama +144 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
Children's Hospital of Orange County, Orange, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Lee Memorial Health System, Fort Myers, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Hospital, West Palm Beach, Florida
Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
University of Hawaii Cancer Center, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Tulane University School of Medicine, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Michigan State University Clinical Center, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Kalamazoo Center for Medical Studies, Kalamazoo, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Overlook Hospital, Summit, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
New York Medical College, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
Mercy Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Legacy Emanuel Hospital and Health Center, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Greenville Cancer Treatment Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
East Tennessee Childrens Hospital, Knoxville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Royal Children's Hospital, Parkville, Victoria
Princess Margaret Hospital for Children, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
San Jorge Children's Hospital, San Juan, Not set
Conditions: Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor, Anaplastic Medulloblastoma, Medulloblastoma, Supratentorial Embryonal Tumor, Not Otherwise Specified
A Safety and Efficacy Study in Patients With Gastric Cancer
Completed
This is an open-label, international, two-arm, parallel, randomized, Phase 3 study evaluating the efficacy and safety of S-1/cisplatin versus 5-FU/cisplatin in patients with advanced gastric cancer previously untreated with chemotherapy for advanced disease. Patients will be randomly assigned (1:1) to S-1/cisplatin (experimental arm) or 5-FU/cisplatin (control arm). Patients will be stratified by number of metastatic sites (one vs. more than one), locally advanced or metastatic disease, prior ad... Read More
This is an open-label, international, two-arm, parallel, randomized, Phase 3 study evaluating the efficacy and safety of S-1/cisplatin versus 5-FU/cisplatin in patients with advanced gastric cancer previously untreated with chemotherapy for advanced disease. Patients will be randomly assigned (1:1) to S-1/cisplatin (experimental arm) or 5-FU/cisplatin (control arm). Patients will be stratified by number of metastatic sites (one vs. more than one), locally advanced or metastatic disease, prior adjuvant therapy (yes or no), measurable or non-measurable disease, and center. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2024
Locations: Clearview Cancer Center, Huntsville, Alabama +32 locations
Clearview Cancer Center, Huntsville, Alabama
Saint Joseph Medical Center, Burbank, California
Dr. Ronald Yanagihara, Gilroy, California
Norris Cancer Center, Los Angeles, California
Comprehensive Cancer Center, Palm Springs, California
Saint Francis Memorial Hospital, San Francisco, California
Premiere Oncology, Santa Monica, California
Western Hematology/Oncology, Lakewood, Colorado
Broward Oncology Associates, Fort Lauderdale, Florida
Alexandar Rosemurgy, Tampa, Florida
Palm Beach Cancer Institute, West Palm Beach, Florida
Straub Clinic and Hospital, Honolulu, Hawaii
Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois
University of Chicago Medical Center, Chicago, Illinois
Oncology and Hematology, Metairie, Louisiana
St. Lukes Cancer Care Center, Duluth, Minnesota
Neuroscience Center, Saint Louis, Missouri
St. Louis University Cancer Center, Saint Louis, Missouri
Southern Nevada Cancer Research Foundation, Las Vegas, Nevada
AHS Lovelace Medical Group,LLC, Albuquerque, New Mexico
New Mexico Cancer Center Associates, Albuquerque, New Mexico
University of New Mexico, Albuquerque, New Mexico
Hoo Chun, MD, Hawthorne, New York
Hematology/Oncology Associates of Rockland, New City, New York
New Bern Cancer Care, New Bern, North Carolina
Abramson Cancer Center, Philadelphia, Pennsylvania
Thomas Jefferson University, Philadelphia, Pennsylvania
Charleston Cancer Center, Charleston, South Carolina
Associates in Oncology and Hematology, Chattanooga, Tennessee
Lexington Oncology Associates, Chattanooga, Tennessee
MD Anderson Cancer Center, Houston, Texas
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin
CHUM Hopital Saint-Luc, Montreal, Quebec
Conditions: Gastric Cancer
Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412)
Completed
The purpose of this study is to determine the efficacy and safety of pembrolizumab given concomitantly with chemoradiation (CRT) and as maintenance therapy versus placebo plus CRT in participants with locally advanced head and neck squamous cell carcinoma (LA HNSCC). The primary hypothesis is that pembrolizumab in combination with CRT is superior to placebo in combination with CRT with respect to event-free survival (EFS).
The purpose of this study is to determine the efficacy and safety of pembrolizumab given concomitantly with chemoradiation (CRT) and as maintenance therapy versus placebo plus CRT in participants with locally advanced head and neck squamous cell carcinoma (LA HNSCC). The primary hypothesis is that pembrolizumab in combination with CRT is superior to placebo in combination with CRT with respect to event-free survival (EFS). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: UCLA Medical Center ( Site 0273), Los Angeles, California +150 locations
UCLA Medical Center ( Site 0273), Los Angeles, California
University of California San Francisco ( Site 0274), San Francisco, California
St. Joseph Heritage Healthcare ( Site 0254), Santa Rosa, California
Smilow Cancer Hospital at Yale New Haven ( Site 0256), New Haven, Connecticut
Rush University Medical Center ( Site 0260), Chicago, Illinois
Indiana University ( Site 0264), Indianapolis, Indiana
Mary Bird Perkins Cancer Center at St. Tammany Parish Hospital ( Site 0281), Baton Rouge, Louisiana
University of Massachusetts Memorial Medical Center ( Site 0285), Worcester, Massachusetts
University of Michigan Hospital and Health Systems ( Site 0267), Ann Arbor, Michigan
Barbara Ann Karmanos Cancer Institute ( Site 0272), Detroit, Michigan
Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center ( Site 0290), Springfield, Missouri
St. Vincent Healthcare Frontier Cancer Center ( Site 0286), Billings, Montana
Comprehensive Cancer Centers of Nevada ( Site 8004), Las Vegas, Nevada
University of Rochester - James P. Wilmot Cancer Center ( Site 0255), Rochester, New York
Oncology Hematology Care, Inc. ( Site 8003), Cincinnati, Ohio
Willamette Valley Cancer Institute and Research Center ( Site 8000), Eugene, Oregon
St. Luke's Cancer Center - Anderson ( Site 0251), Easton, Pennsylvania
St. Francis Hospital Cancer Center ( Site 1461), Greenville, South Carolina
Texas Oncology-Arlington North ( Site 8005), Arlington, Texas
Texas Oncology-Austin Central ( Site 8002), Austin, Texas
Texas Oncology PA ( Site 8001), Longview, Texas
University of Virginia Health System ( Site 0261), Charlottesville, Virginia
Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 0269), Seattle, Washington
Medical Oncology Associates (Summit Cancer Centers) ( Site 0257), Spokane, Washington
Liverpool Hospital ( Site 0301), Liverpool, New South Wales (Australia)
Blacktown Hospital Western Sydney Local Health District ( Site 0304), Blacktown, New South Wales
Princess Alexandra Hospital ( Site 0305), Brisbane, Queensland
Royal Brisbane and Women s Hospital ( Site 0302), Herston, Queensland
Royal Adelaide Hospital ( Site 0303), Adelaide, South Australia
Peter MacCallum Cancer Centre ( Site 0300), Melbourne, Victoria
Landeskrankenhaus - Universitatsklinikum Graz ( Site 0601), Graz, Not set
Krankenhaus der Barmherzigen Schwestern Linz ( Site 0603), Linz, Not set
Landeskrankenhaus Salzburg ( Site 0600), Salzburg, Not set
Allgemeines Krankenhaus der Stadt Wien ( Site 0602), Vienna/Wien, Not set
Cliniques Universitaires Saint Luc - Bruxelles ( Site 0651), Brussels, Not set
UZ Gent ( Site 0650), Gent, Not set
UZ Leuven Campus Gasthuisberg ( Site 0652), Leuven, Not set
C.H.U. Sart Tilman-Service d'Oncologie Medicale ( Site 0654), Liege, Not set
Clinique et Maternite Sainte-Elisabeth ( Site 0653), Namur, Not set
Hospital Santa Izabel - Santa Casa de Misericordia da Bahia ( Site 0006), Salvador, Bahia
Centro Regional Integrado de Oncologia ( Site 0002), Fortaleza, Ceara
Liga Norte Riograndense Contra o Cancer ( Site 0005), Natal, Rio Grande Do Norte
Hospital Nossa Senhora da Conceicao ( Site 0001), Porto Alegre, Rio Grande Do Sul
Hospital de Clinicas de Porto Alegre ( Site 0011), Porto Alegre, RS
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0003), Barretos, Sao Paulo
Instituto do Cancer de Sao Paulo - ICESP ( Site 0004), Sao Paulo, SP
Hospital das Clinicas da FMUSP de Ribeirao Preto ( Site 0008), Ribeirao Preto, Not set
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0010), Rio de Janeiro, Not set
Tom Baker Cancer Centre ( Site 0063), Calgary, Alberta
Cross Cancer Institute ( Site 0064), Edmonton, Alberta
Juravinski Cancer Centre ( Site 0062), Hamilton, Ontario
London Health Sciences Centre ( Site 0055), London, Ontario
The Ottawa Hospital - Cancer Care ( Site 0052), Ottawa, Ontario
Princess Margaret Cancer Centre ( Site 0051), Toronto, Ontario
McGill University Health Centre ( Site 0061), Montreal, Quebec
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0057), Sherbrooke, Quebec
Hospital Pablo Tobon Uribe ( Site 0151), Medellin, Antioquia
Fundacion Valle del Lili ( Site 0150), Cali, Valle Del Cauca
Centro Medico Imbanaco de Cali S.A ( Site 0156), Cali, Valle Del Cauca
Centro de Investigacion Clinica del Country ( Site 0155), Bogota, Not set
FN Brno. ( Site 0703), Brno, Not set
Fakultni Nemocnice Hradec Kralove ( Site 0705), Hradec Kralove, Not set
Fakultni nemocnice Olomouc ( Site 0701), Olomouc, Not set
Fakultni nemocnice Ostrava ( Site 0702), Ostrava, Not set
Nemocnice Na Bulovce ( Site 0700), Praha 8, Not set
2. LF UK a FN Motol ( Site 0704), Praha, Not set
Centre Jean Bernard Laboratoire Mahe Meziani ( Site 0760), Le Mans, Not set
Clinique Francois Chenieux ( Site 0757), Limoges, Not set
Institut Claudius Regaud ( Site 0754), Toulouse Cedex 09, Not set
Institut De Cancerologie De Lorraine ( Site 0758), Vandoeuvre les Nancy, Not set
Institut Gustave Roussy ( Site 0759), Villejuif, Not set
Universitätsklinikum Erlangen ( Site 0801), Erlangen, Not set
SRH Waldklinikum Gera GmbH ( Site 0802), Gera, Not set
Universitares Cancer Center Hamburg - UCCH ( Site 0811), Hamburg, Not set
Medizinische Hochschule Hannover ( Site 0807), Hannover, Not set
Universitaetsklinikum Schleswig-Holstein-Campus Luebeck ( Site 0803), Luebeck, Not set
Klinikum der Universitaet Munchen ( Site 0810), Munchen, Not set
Universitaetsklinik Ulm ( Site 0804), Ulm, Not set
Rambam MC ( Site 0903), Haifa, Not set
Hadassah Ein Karem Jerusalem ( Site 0902), Jerusalem, Not set
Rabin Medical Center ( Site 0904), Petah Tikva, Not set
Sheba MC ( Site 0901), Ramat Gan, Not set
Tel Aviv Sourasky Medical Center ( Site 0900), Tel Aviv, Not set
Azienda Ospedaliero Universitaria di Modena Policlinico ( Site 0954), Modena, MO
Azienda Ospedaliero Universitaria Careggi ( Site 0955), Firenze, Not set
Istituto Nazionale Tumori ( Site 0950), Milano, Not set
Istituto Europeo di Oncologia ( Site 0953), Milano, Not set
Azienda Ospedaliera San Paolo ( Site 0952), Milano, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0951), Napoli, Not set
Istituto Oncologico Veneto ( Site 0957), Padova, Not set
Fondazione IRCCS - Policlinico San Matteo ( Site 0960), Pavia, Not set
National Cancer Center Hospital East ( Site 0350), Kashiwa, Chiba
Hokkaido University Hospital ( Site 0351), Sapporo, Hokkaido
Hyogo Cancer Center ( Site 0354), Akashi, Hyogo
Kagawa University Hospital ( Site 0359), Kita-gun, Kagawa
Miyagi Cancer Center ( Site 0353), Natori, Miyagi
Chiba Cancer Center ( Site 0358), Chiba, Not set
Hiroshima University Hospital ( Site 0352), Hiroshima, Not set
Osaka International Cancer Institute ( Site 0355), Osaka, Not set
Medical Hospital, Tokyo Medical And Dental University ( Site 0356), Tokyo, Not set
The Cancer Institute Hospital of JFCR ( Site 0357), Tokyo, Not set
Chungbuk National University Hospital ( Site 0454), Cheongju si, Chungcheongbuk Do
Seoul National University Bundang Hospital ( Site 0453), Seongnam-si, Gyeonggi-do
Chungnam National University Hospital ( Site 0455), Daejeon, Not set
Severance Hospital Yonsei University Health System ( Site 0452), Seoul, Not set
Samsung Medical Center ( Site 0450), Seoul, Not set
Noordwest Ziekenhuisgroep NWZ ( Site 1350), Alkmaar, Not set
VU Medisch Centrum ( Site 1352), Amsterdam, Not set
UMCG ( Site 1351), Groningen, Not set
UMC St. Radboud ( Site 1356), Nijmegen, Not set
Erasmus University Medical Center ( Site 1354), Rotterdam, Not set
Capital & Coast District Health Board - Wellington Hospital ( Site 0400), Wellington, Newtown
Dolnoslaskie Centrum Onkologii. ( Site 1001), Wroclaw, Dolnoslaskie
Mazowiecki Szpital Onkologiczny ( Site 1015), Wieliszew, Mazowieckie
Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1005), Bielsko-Biala, Not set
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1007), Gdynia, Not set
Centrum Onkologii. Instytut im. Marii Sklodowskiej-Curie ( Site 1010), Gliwice, Not set
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1008), Krakow, Not set
Zachodniopomorskie Centrum Onkologii ( Site 1013), Szczecin, Not set
Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie ( Site 1000), Warszawa, Not set
H.U. Vall de Hebron ( Site 1052), Barcelona, Not set
Hospital Duran i Reynals ( Site 1053), Hospitalet de Llobregat, Not set
Hospital Doce de Octubre ( Site 1054), Madrid, Not set
Hospital Universitario Ramon y Cajal ( Site 1055), Madrid, Not set
Hospital Clinico San Carlos ( Site 1051), Madrid, Not set
Hospital Universitario Virgen de la Victoria ( Site 1056), Malaga, Not set
Hospital Gral Universitario de Valencia ( Site 1050), Valencia, Not set
Chang Gung Medical Foundation - Kaohsiung ( Site 0501), Kaohsiung, Not set
Taichung Veterans General Hospital ( Site 0506), Taichung, Not set
National Cheng Kung University Hospital ( Site 0503), Tainan, Not set
National Taiwan University Hospital ( Site 0500), Taipei, Not set
MacKay Memorial Hospital ( Site 0505), Taipei, Not set
Taipei Veterans General Hospital ( Site 0504), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 0502), Taoyuan, Not set
Basken Adana Dr.Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 1103), Adana, Not set
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1102), Ankara, Not set
Ankara Sehir Hastanesi ( Site 1108), Ankara, Not set
Istanbul Universitesi Istanbul Tip Fakultesi ( Site 1100), Istanbul, Not set
Medipol Universite Hastanesi ( Site 1104), Istanbul, Not set
Medical Park Izmir Hastanesi ( Site 1109), Izmir, Not set
Kocaeli Universitesi Tip Fakultesi ( Site 1106), Kocaeli, Not set
Inonu Universitesi Tip Fakultesi ( Site 1101), Malatya, Not set
Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 1206), Norwich, Norfolk
University Hospital of North Staffordshire ( Site 1202), Stoke-On-Trent, Staffordshire
Ipswich Hospital ( Site 1207), Ipswich, Suffolk
St Bartholomew s Hospital ( Site 1205), London, Not set
The Royal Marsden Foundation Trust ( Site 1200), London, Not set
Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 1204), London, Not set
Lancashire Teaching Hospitals NHS Foundation Trust ( Site 1208), Preston, Not set
University Hospital Southampton NHS Foundation Trust ( Site 1203), Southampton, Not set
Royal Marsden NHS Foundation Trust ( Site 1201), Sutton, Not set
Conditions: Head and Neck Neoplasms
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