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Cisplatin Treatment Options in Canada
A collection of 326 research studies where Cisplatin is the interventional treatment. These studies are located in the Canada . Cisplatin is used for conditions such as Head and Neck Cancer, Lung Cancer and Non-small Cell Lung Cancer.
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Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Recruiting
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab bi... Read More
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma. Read Less
Gender:
ALL
Ages:
30 years and below
Trial Updated:
07/31/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +158 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
University of Rochester, Rochester, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer
Recruiting
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, wor... Read More
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The purpose of this study is to compare the usual treatment (radiation therapy with cisplatin chemotherapy) to using radiation therapy with docetaxel and cetuximab chemotherapy, and using the usual treatment plus an immunotherapy drug, atezolizumab. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +325 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
The Kirklin Clinic at Acton Road, Birmingham, Alabama
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California
Mercy San Juan Medical Center, Carmichael, California
UC San Diego Health System - Encinitas, Encinitas, California
UC San Diego Moores Cancer Center, La Jolla, California
Cedars Sinai Medical Center, Los Angeles, California
Memorial Medical Center, Modesto, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Saint Helena Hospital, Saint Helena, California
UCSF Medical Center-Mount Zion, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Mills Health Center, San Mateo, California
UCHealth University of Colorado Hospital, Aurora, Colorado
Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
AdventHealth Porter, Denver, Colorado
Shaw Cancer Center, Edwards, Colorado
Banner North Colorado Medical Center, Greeley, Colorado
Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado
Longmont United Hospital, Longmont, Colorado
Banner McKee Medical Center, Loveland, Colorado
AdventHealth Parker, Parker, Colorado
University of Connecticut, Farmington, Connecticut
Yale University, New Haven, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Helen F Graham Cancer Center, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
George Washington University Medical Center, Washington, District of Columbia
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
Holy Cross Hospital, Fort Lauderdale, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Moffitt Cancer Center, Tampa, Florida
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
Queen's Medical Center, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho
Northwestern University, Chicago, Illinois
John H Stroger Jr Hospital of Cook County, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Crossroads Cancer Center, Effingham, Illinois
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois
NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois
NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Ascension Saint Vincent Anderson, Anderson, Indiana
Elkhart General Hospital, Elkhart, Indiana
Radiation Oncology Associates PC, Fort Wayne, Indiana
Parkview Hospital Randallia, Fort Wayne, Indiana
Parkview Regional Medical Center, Fort Wayne, Indiana
Goshen Center for Cancer Care, Goshen, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
IU Health Methodist Hospital, Indianapolis, Indiana
IU Health Central Indiana Cancer Centers-East, Indianapolis, Indiana
Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana
Memorial Hospital of South Bend, South Bend, Indiana
McFarland Clinic - Ames, Ames, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
Tulane University School of Medicine, New Orleans, Louisiana
University Medical Center New Orleans, New Orleans, Louisiana
Touro Infirmary, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Greater Baltimore Medical Center, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
UM Upper Chesapeake Medical Center, Bel Air, Maryland
Central Maryland Radiation Oncology in Howard County, Columbia, Maryland
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland
Holy Cross Hospital, Silver Spring, Maryland
Boston Medical Center, Boston, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
University of Michigan - Brighton Center for Specialty Care, Brighton, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Henry Ford Hospital, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Allegiance Health, Jackson, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
University of Michigan Health - West, Wyoming, Michigan
Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Miller-Dwan Hospital, Duluth, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Saint Francis Medical Center, Cape Girardeau, Missouri
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
North Kansas City Hospital, Kansas City, Missouri
The University of Kansas Cancer Center-South, Kansas City, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
CHI Health Good Samaritan, Kearney, Nebraska
Nebraska Methodist Hospital, Omaha, Nebraska
Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
The Cancer Institute of New Jersey Hamilton, Hamilton, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Virtua Memorial, Mount Holly, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
Sparta Cancer Treatment Center, Sparta, New Jersey
Community Medical Center, Toms River, New Jersey
Virtua Voorhees, Voorhees, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
New Mexico Oncology Hematology Consultants, Albuquerque, New Mexico
South Shore University Hospital, Bay Shore, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
NYU Langone Hospital - Brooklyn, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
Sands Cancer Center, Canandaigua, New York
Memorial Sloan Kettering Commack, Commack, New York
Arnot Ogden Medical Center/Falck Cancer Center, Elmira, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Northwell Health/Center for Advanced Medicine, Lake Success, New York
NYU Langone Hospital - Long Island, Mineola, New York
Mount Sinai Union Square, New York, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Wilmot Cancer Institute Radiation Oncology at Greece, Rochester, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow, New York
State University of New York Upstate Medical University, Syracuse, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Atrium Health Stanly/LCI-Albemarle, Albemarle, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Atrium Health Pineville/LCI-Pineville, Charlotte, North Carolina
Atrium Health University City/LCI-University, Charlotte, North Carolina
Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina
East Carolina University, Greenville, North Carolina
ECU Health Oncology Kinston, Kinston, North Carolina
Atrium Health Union/LCI-Union, Monroe, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Bismarck Medical Center, Bismarck, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
Cleveland Clinic Akron General, Akron, Ohio
UH Seidman Cancer Center at UH Avon Health Center, Avon, Ohio
Summa Health System - Barberton Campus, Barberton, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Geauga Hospital, Chardon, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Mercy Cancer Center-Elyria, Elyria, Ohio
Cleveland Clinic Cancer Center Independence, Independence, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
Summa Health Medina Medical Center, Medina, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights, Ohio
University Hospitals Parma Medical Center, Parma, Ohio
Southern Ohio Medical Center, Portsmouth, Ohio
University Hospitals Portage Medical Center, Ravenna, Ohio
North Coast Cancer Care, Sandusky, Ohio
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
UHHS-Westlake Medical Center, Westlake, Ohio
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Clackamas Radiation Oncology Center, Clackamas, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
UPMC Altoona, Altoona, Pennsylvania
UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania
Carlisle Regional Cancer Center, Carlisle, Pennsylvania
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
IRMC Cancer Center, Indiana, Pennsylvania
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania
UPMC Cancer Center at UPMC McKeesport, McKeesport, Pennsylvania
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania
UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center in Coraopolis, Moon, Pennsylvania
UPMC Cancer Center-Natrona Heights, Natrona Heights, Pennsylvania
UPMC Jameson, New Castle, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Temple University Hospital, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Margaret, Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
UPMC Jefferson Regional Radiation Oncology, Pittsburgh, Pennsylvania
UPMC-Passavant Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania
UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania
UPMC Uniontown Hospital Radiation Oncology, Uniontown, Pennsylvania
UPMC Washington Hospital Radiation Oncology, Washington, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Wexford Health and Wellness Pavilion, Wexford, Pennsylvania
AnMed Health Cancer Center, Anderson, South Carolina
Saint Joseph's/Candler - Bluffton Campus, Bluffton, South Carolina
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Prisma Health Cancer Institute - Greer, Greer, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
Rock Hill Radiation Therapy Center, Rock Hill, South Carolina
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
Rapid City Regional Hospital, Rapid City, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
MD Anderson in The Woodlands, Conroe, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
University of Texas Medical Branch, Galveston, Texas
M D Anderson Cancer Center, Houston, Texas
MD Anderson West Houston, Houston, Texas
MD Anderson League City, League City, Texas
UTMB Cancer Center at Victory Lakes, League City, Texas
Covenant Medical Center-Lakeside, Lubbock, Texas
MD Anderson in Sugar Land, Sugar Land, Texas
Intermountain Medical Center, Murray, Utah
Saint George Regional Medical Center, Saint George, Utah
Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Sentara Cancer Institute at Sentara CarePlex Hospital, Hampton, Virginia
Sentara Norfolk General Hospital, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Sentara Virginia Beach General Hospital, Virginia Beach, Virginia
Saint Francis Hospital, Federal Way, Washington
Tri-Cities Cancer Center, Kennewick, Washington
PeaceHealth Saint John Medical Center, Longview, Washington
Skagit Regional Health Cancer Care Center, Mount Vernon, Washington
University of Washington Medical Center - Montlake, Seattle, Washington
Spokane Valley Cancer Center-Mayfair, Spokane, Washington
Spokane Valley Cancer Center-Mission, Spokane, Washington
Wenatchee Valley Hospital and Clinics, Wenatchee, Washington
West Virginia University Healthcare, Morgantown, West Virginia
Camden Clark Medical Center, Parkersburg, West Virginia
Wheeling Hospital/Schiffler Cancer Center, Wheeling, West Virginia
Langlade Hospital and Cancer Center, Antigo, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Bay Area Medical Center, Marinette, Wisconsin
Marshfield Medical Center, Marshfield, Wisconsin
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
Cancer Center of Western Wisconsin, New Richmond, Wisconsin
Drexel Town Square Health Center, Oak Creek, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Cross Cancer Institute, Edmonton, Alberta
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Chinese University of Hong Kong-Prince of Wales Hospital, Shatin, Not set
Conditions: Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7, Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7, Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma
Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Nonsquamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006)
Active Not Recruiting
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, versus (vs) pembrolizumab plus maintenance pemetrexed for the treatment of non-squamous NSCLC. The study's 2 primary hypotheses are: 1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance pemetrexed with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by blinded independent clinical review (BICR) and 2. Pembrolizu... Read More
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, versus (vs) pembrolizumab plus maintenance pemetrexed for the treatment of non-squamous NSCLC. The study's 2 primary hypotheses are: 1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance pemetrexed with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by blinded independent clinical review (BICR) and 2. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance pemetrexed with respect to overall survival (OS). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham, Alabama +177 locations
Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham, Alabama
Northwest Alabama Cancer Center, PC ( Site 0002), Muscle Shoals, Alabama
Disney Family Cancer Center ( Site 0005), Burbank, California
Boca Raton Regional Hospital ( Site 0018), Boca Raton, Florida
Mid-Florida Cancer Centers ( Site 0022), Orange City, Florida
Moffitt Cancer Center ( Site 0024), Tampa, Florida
Columbus Regional Research Institute ( Site 0098), Columbus, Georgia
Mount Sinai Hospital Medical Center ( Site 0032), Chicago, Illinois
Oncology of Northshore ( Site 0033), Rolling Meadows, Illinois
Methodists Hospitals/Premier Oncology Hematology Associates ( Site 0036), Merrillville, Indiana
Medstar Good Samaritan Hospital ( Site 0040), Baltimore, Maryland
Barbara Ann Karmanos Cancer Institute ( Site 0041), Detroit, Michigan
Hattiesburg Clinic ( Site 0045), Hattiesburg, Mississippi
Frontier Oncology ( Site 0080), Billings, Montana
Bozeman Health Deaconness Cancer Center ( Site 0046), Bozeman, Montana
Waverly Hematology Oncology ( Site 0081), Cary, North Carolina
Thompson Cancer Survival Center ( Site 2812), Knoxville, Tennessee
University of Tennessee Medical Center Knoxville ( Site 0060), Knoxville, Tennessee
Renovatio Clinical ( Site 0062), The Woodlands, Texas
Cancer Care Northwest ( Site 0071), Spokane Valley, Washington
Hospital Italiano Regional del Sur ( Site 0509), Bahia Blanca, Buenos Aires
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0511), Ciudad Autonoma de Buenos Aires, Buenos Aires
Hospital Britanico de Buenos Aires ( Site 0500), Ciudad autónoma de Buenos Aires, Buenos Aires
Instituto Medico Rio Cuarto ( Site 0501), Rio Cuarto., Cordoba
Centro Oncológico de Rosario ( Site 0507), Rosario, Santa Fe
Centro Medico San Roque ( Site 0506), San Miguel de Tucuman, Tucuman
Clínica Universitaria Reina Fabiola ( Site 0505), Cordoba, Not set
Sanatorio Privado San Geronimo S.R.L ( Site 0510), Santa Fe, Not set
Liverpool Hospital ( Site 1201), Liverpool, New South Wales
Southern Medical Day Care Centre ( Site 1200), Wollongong, New South Wales
Townsville General Hospital ( Site 1202), Townsville, Queensland
Monash Cancer Centre ( Site 1205), Clayton, Victoria
Ordensklinikum Linz GmbH Elisabethinen ( Site 1307), Linz, Oberosterreich
Klinikum Wels-Grieskirchen ( Site 1304), Wels, Oberosterreich
Innsbruck LKH ( Site 1302), Innsbruck, Tirol
Social Medical Center - Otto Wagner Hospital ( Site 1301), Vienna, Wien
Krankenhaus Nord - Klinik Floridsdorf ( Site 1300), Wien, Not set
Hospital Sao Rafael ( Site 0212), Salvador, Bahia
Instituto do Cancer do Ceara ( Site 0201), Fortaleza, Ceara
Oncologica do Brasil ( Site 0210), Belem, Para
Hospital Tacchini ( Site 0208), Bento Goncalves, Rio Grande Do Sul
Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0209), Porto Alegre, Rio Grande Do Sul
Saint Gallen Instituto de Oncologia ( Site 0206), Santa Cruz do Sul, Rio Grande Do Sul
YNOVA Pesquisa Clinica ( Site 0215), Florianopolis, Santa Catarina
Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0202), Itajai, Santa Catarina
Centro de Hematologia e Oncologia ( Site 0205), Joinville, Santa Catarina
Hospital de Base de Sao Jose de Rio Preto ( Site 0204), Sao Jose Rio Preto, Sao Paulo
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0203), Rio de Janeiro, Not set
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0200), Sao Paulo, Not set
BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0214), Sao Paulo, Not set
Hospital Paulistano - Amil Clinical Research ( Site 0207), Sao Paulo, Not set
Lions Gate Hospital ( Site 0106), North Vancouver, British Columbia
BC Cancer - Victoria ( Site 0109), Victoria, British Columbia
Queen Elizabeth II Health Sciences Centre ( Site 0107), Halifax, Nova Scotia
Waterloo Regional Health Network (WRHN) ( Site 0117), Kitchener, Ontario
Stronach Regional Cancer Centre ( Site 0101), Newmarket, Ontario
Health Sciences North Research Institute ( Site 0115), Sudbury, Ontario
CISSS de la Monteregie-Centre ( Site 0114), Greenfield Park, Quebec
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0105), Montreal, Quebec
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0110), Montreal, Quebec
Centre de Sante et des Services Sociaux de Rimouski-Neigette ( Site 0104), Rimouski, Quebec
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0103), Sherbrooke, Quebec
Fundacion Colombiana de Cancerologia Clinica Vida ( Site 0604), Medellin, Antioquia
Clinica de la Costa S.A.S. ( Site 0608), Barranquilla, Atlantico
Administradora Country S.A. ( Site 0603), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 0601), Bogotá, Distrito Capital De Bogota
Institut De Cancerologie De Lorraine ( Site 1409), Vandoeuvre les Nancy, Ain
Centre Hospitalier De Chauny ( Site 1411), Chauny, Aisne
CHU Caen ( Site 1406), Caen, Calvados
CHU Angers ( Site 1405), Angers, Maine-et-Loire
Hopital Robert Schuman ( Site 1402), Vantoux, Moselle
Centre Jean Perrin ( Site 1407), Clermont Ferrand, Puy-de-Dome
Centre Hospitalier de Pau ( Site 1412), Pau, Pyrenees-Atlantiques
CHU de Rouen ( Site 1403), Rouen, Seine-Maritime
Hopital d'Instruction des Armees Begin ( Site 1413), Saint-Mande, Val-de-Marne
Studienzentrum Aschaffenburg ( Site 1525), Aschaffenburg, Bayern
Klinikum Bogenhausen Staedt. Klinikum Muenchen GmbH ( Site 1523), Muenchen, Bayern
Klinikum der LMU ( Site 1500), Munich, Bayern
Universitaetsklinikum Regensburg ( Site 1512), Regensburg, Bayern
Klinikum Wuerzburg Mitte gGmbH ( Site 1509), Wuerzburg, Bayern
Universitaetsklinikum Frankfurt ( Site 1513), Frankfurt, Hessen
Pneumologische Lehrklinik Universitaet Goettingen ( Site 1501), Immenhausen, Hessen
Universitaetsmedizin Goettingen ( Site 1507), Goettingen, Niedersachsen
Universitaetsklinikum Bonn ( Site 1524), Bonn, Nordrhein-Westfalen
Kliniken Essen Mitte ( Site 1517), Essen, Nordrhein-Westfalen
InVo-Institut fuer Versorgungsforschung in der Onkologie ( Site 1514), Koblenz, Rheinland-Pfalz
Helios Klinikum Erfurt GmbH ( Site 1502), Erfurt, Thuringen
Katholisches Marienkrankenhaus gGmbH ( Site 1522), Hamburg, Not set
National Hospital Organization Nagoya Medical Center ( Site 0806), Nagoya, Aichi
Aichi Cancer Center ( Site 0803), Nagoya, Aichi
National Cancer Center Hospital East ( Site 0801), Kashiwa, Chiba
Kanazawa University Hospital ( Site 0811), Kanazawa, Ishikawa
Kanagawa Cancer Center ( Site 0807), Yokohama, Kanagawa
Sendai Kousei Hospital ( Site 0812), Sendai, Miyagi
Kansai Medical University Hospital ( Site 0804), Hirakata, Osaka
National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0813), Sakai, Osaka
Shizuoka Cancer Center ( Site 0802), Suntogun, Shizuoka
National Hospital Organization Kyushu Medical Center ( Site 0805), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 0808), Niigata, Not set
Okayama University Hospital ( Site 0810), Okayama, Not set
Osaka International Cancer Institute ( Site 0809), Osaka, Not set
Cancer Institute Hospital of JFCR ( Site 0800), Tokyo, Not set
Chungbuk National University Hospital ( Site 1002), Cheongju si, Chungbuk
National Cancer Center ( Site 1006), Goyang-si, Kyonggi-do
The Catholic University of Korea St. Vincent s Hospital ( Site 1003), Suwon, Kyonggi-do
Ajou University Hospital ( Site 1004), Suwon, Kyonggi-do
Gyeongsang National University Hospital ( Site 1005), Jinju, Kyongsangnam-do
Asan Medical Center ( Site 1007), Songpa-gu, Seoul
Seoul National University Hospital ( Site 1000), Seoul, Not set
Korea University Guro Hospital ( Site 1008), Seoul, Not set
MidCentral DHB Palmerston North Hospital ( Site 1102), Palmerston North, Manawatu-Wanganui
Capital & Coast District Health Board - Wellington Hospital ( Site 1101), Wellington, Not set
Wielospecjalistyczny Szpital SPZOZ w Zgorzelcu ( Site 2404), Zgorzelec, Dolnoslaskie
Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 2420), Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2418), Warszawa, Mazowieckie
Szpital Rejonowy im. dr Jozefa Rostka ( Site 2402), Raciborz, Slaskie
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 2417), Olsztyn, Warminsko-mazurskie
Przychodnia Lekarska Komed ( Site 2416), Konin, Wielkopolskie
MED-POLONIA Sp. z o.o. ( Site 2419), Poznan, Wielkopolskie
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2502), Bucharest, Bucuresti
Cardiomed SRL Cluj-Napoca ( Site 2504), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 2507), Cluj-Napoca, Cluj
Ovidius Clinical Hospital OCH ( Site 2501), Ovidiu, Constanta
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2508), Craiova, Dolj
Policlinica Oncomed SRL ( Site 2505), Timisoara, Timis
Spitalul PDR Medlife ( Site 2509), Brasov, Not set
Moscow Regional Oncological Dispensary ( Site 2028), Balashikha, Moskovskaya Oblast
Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 2000), Moscow, Moskva
First Moscow State Medical University n.a. I.M.Sechenov ( Site 2024), Moscow, Moskva
Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2009), Moscow, Moskva
FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 2006), Moscow, Moskva
Nizhniy Novgorod Region Oncology Dispensary ( Site 2026), Nizhniy Novgorod, Nizhegorodskaya Oblast
Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site 2010), Omsk, Omskaya Oblast
SBHI Samara Regional Clinical Oncology Dispensary ( Site 2016), Samara, Samarskaya Oblast
SBHI Leningrad Regional Clinical Hospital ( Site 2002), Saint Petersburg, Sankt-Peterburg
SPb Central Clinical Railway Hospital ( Site 2003), Saint Petersburg, Sankt-Peterburg
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 2004), Saint Petersburg, Sankt-Peterburg
SPb SBHI City Clinical Oncological Dispensary ( Site 2001), Saint Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 2021), Kazan, Tatarstan, Respublika
Hospital Universitario Quiron Madrid ( Site 1701), Pozuelo de Alarcon, Madrid
Hospital Clinico Universitario de Valencia ( Site 1706), Valencia, Valenciana, Comunitat
Hospital del Mar ( Site 1702), Barcelona, Not set
Hospital Universitario Nuestra Senora de Valme ( Site 1703), Sevilla, Not set
Hospital Clinico Lozano Blesa ( Site 1700), Zaragoza, Not set
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0907), Kaohsiung, Not set
China Medical University Hospital ( Site 0904), Taichung, Not set
National Cheng Kung University Hospital ( Site 0905), Tainan, Not set
National Taiwan University Hospital ( Site 0900), Taipei, Not set
Mackay Memorial Hospital ( Site 0902), Taipei, Not set
Chang Gung Medical Foundation.Linkou Branch ( Site 0903), Taoyuan, Not set
Namik Kemal Universitesi Tip Fakultesi ( Site 2100), Tekirdag, Tekirdas
Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 2101), Adana, Not set
Gazi Universitesi Tip Fakultesi ( Site 2104), Ankara, Not set
Ankara Bilkent Sehir Hastanesi ( Site 2105), Ankara, Not set
Bezmialem Vakif Univ. Tıp Fakultesi Hastanesi Tibbi Onkoloji Bolumu ( Site 2107), Istanbul, Not set
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2103), Istanbul, Not set
Ege Universitesi Tip Fakultesi ( Site 2109), Izmir, Not set
Erciyes Universitesi Tip Fakultesi ( Site 2108), Kayseri, Not set
Ondokuz Mayıs Universitesi-Oncology department ( Site 2106), Samsun, Not set
Cherkasy Regional Oncology Dispensary ( Site 2211), Cherkasy, Cherkaska Oblast
Municipal Non-Profit Enterprise City Clinical Hospital 4 of Dnipro City Council ( Site 2201), Dnipro, Dnipropetrovska Oblast
MI Precarpathian Clinical Oncology Center ( Site 2204), Ivano-Frankivsk, Ivano-Frankivska Oblast
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2212), Kharkiv, Kharkivska Oblast
CNPE "Regional Center of Oncology"-Thoracic organs ( Site 2205), Kharkiv, Kharkivska Oblast
PP PPC Acinus Medical and Diagnostic Centre ( Site 2209), Kropyvnitskiy, Kirovohradska Oblast
Medical Center Asklepion LLC ( Site 2234), Khodosivka, Kyivska Oblast
Medical Center Verum ( Site 2230), Kyiv, Kyivska Oblast
Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2213), Kyiv, Kyivska Oblast
MI Odessa Regional Oncological Centre ( Site 2208), Odesa, Odeska Oblast
Central City Clinical Hospital ( Site 2207), Uzhgorod, Zakarpatska Oblast
Kyiv City Clinical Oncology Centre ( Site 2210), Kyiv, Not set
Barts Health NHS Trust - St Bartholomew s Hospital ( Site 1923), London, London, City Of
Chelsea and Westminster Hospital ( Site 1901), London, London, City Of
West Suffolk Hospitals NHS Trust ( Site 1919), Bury Saint Edmunds, Suffolk
Singleton Hospital ( Site 1909), Swansea, Wales
Colchester General Hospital ( Site 1911), Colchester, Worcestershire
Birmingham Heartlands Hospital ( Site 1910), Birmingham, Not set
Western General Hospital, Edinburgh ( Site 1924), Edinburg, Not set
Conditions: Carcinoma, Nonsquamous Non-small-cell Lung
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Recruiting
The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).
The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Banner MD Anderson Cancer Center ( Site 0181), Gilbert, Arizona +151 locations
Banner MD Anderson Cancer Center ( Site 0181), Gilbert, Arizona
Providence St. Jude Medical Center ( Site 0106), Fullerton, California
UCSF Medical Center at Mission Bay ( Site 0178), San Francisco, California
UCHealth Memorial Hospital Central ( Site 0125), Colorado Springs, Colorado
Banner MD Anderson Cancer Center at North Colorado Medical Center ( Site 0207), Greeley, Colorado
Beacon Cancer Care ( Site 0127), Post Falls, Idaho
The University of Chicago Medical Center ( Site 0118), Chicago, Illinois
Massachusetts General Hospital ( Site 0136), Boston, Massachusetts
Dana Farber Cancer Hospital ( Site 0155), Boston, Massachusetts
Ellis Fischel Cancer Center ( Site 0133), Columbia, Missouri
Lake Regional Hospital-Cancer Center ( Site 0123), Osage Beach, Missouri
Montefiore Medical Center ( Site 0160), Bronx, New York
Roswell Park Cancer Institute ( Site 0184), Buffalo, New York
Hematology-Oncology Associates of CNY ( Site 0164), East Syracuse, New York
Icahn School of Medicine at Mount Sinai ( Site 0116), New York, New York
Memorial Sloan Kettering Cancer Center ( Site 0137), New York, New York
SUNY Upstate Cancer Center ( Site 0140), Syracuse, New York
Westchester Medical Center ( Site 0196), Valhalla, New York
University of Cincinnati Medical Center ( Site 0119), Cincinnati, Ohio
St. Lukes Hospital and Health Network ( Site 0186), Bethlehem, Pennsylvania
Thompson Cancer Survival Center ( Site 0168), Knoxville, Tennessee
MD Anderson Cancer Center ( Site 0150), Houston, Texas
Memorial Hermann Cancer Center ( Site 0172), Houston, Texas
O'Quinn Medical Tower at McNair Campus ( Site 0131), Houston, Texas
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0148), Tyler, Texas
Swedish Cancer Institute ( Site 0143), Seattle, Washington
Virginia Mason Franciscan Health - St. Michael Cancer Center ( Site 0192), Silverdale, Washington
CEMIC ( Site 2454), Caba., Buenos Aires
Fundacion Intecnus ( Site 2456), San Carlos de Bariloche, Rio Negro
Centro Médico IPAM ( Site 2452), Rosario, Santa Fe
Instituto Medico Especializado Alexander Fleming ( Site 2457), Buenos Aires, Not set
Instituto Oncologico de Cordoba -IONC ( Site 2455), Cordoba, Not set
Calvary Mater Newcastle ( Site 2106), Waratah, New South Wales
Tasman Oncology Research ( Site 2104), Southport, Queensland
Princess Alexandra Hospital ( Site 2102), Wooloongabba, Queensland
Grampians Health ( Site 2101), Ballarat, Victoria
One Clinical Research ( Site 2103), Nedlands, Western Australia
Cliniques Universitaires Saint-Luc ( Site 1203), Bruxelles, Bruxelles-Capitale, Region De
Jessa Ziekenhuis ( Site 1204), Hasselt, Limburg
UZ Gent ( Site 1201), Gent, Oost-Vlaanderen
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 2502), Fortaleza, Ceara
Liga Norte Riograndense Contra o Cancer ( Site 2513), Natal, Rio Grande Do Norte
Hospital Tacchini ( Site 2506), Bento Goncalves, Rio Grande Do Sul
Hospital de Clínicas de Passo Fundo ( Site 2504), Passo Fundo, Rio Grande Do Sul
Hospital Moinhos de Vento ( Site 2510), Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora Da Conceicao ( Site 2512), Porto Alegre, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 2507), Santa Cruz do Sul, Rio Grande Do Sul
Hospital de Amor - Barretos ( Site 2511), Barretos, Sao Paulo
Instituto Nacional de Câncer - INCA ( Site 2501), Rio de Janeiro, Not set
MBAL Uni Hospital ( Site 1253), Panagyurishte, Pazardzhik
MHAT - Heart and Brain ( Site 1252), Pleven, Not set
Queen Elizabeth II Health Sciences Centre ( Site 1101), Halifax, Nova Scotia
Hamilton Health Sciences - Juravinski Site ( Site 1104), Hamilton, Ontario
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 1105), Kingston, Ontario
Lakeridge Health ( Site 1107), Oshawa, Ontario
McGill University Health Centre ( Site 1103), Montréal, Quebec
IUCPQ ( Site 1112), Québec, Quebec
FALP ( Site 2551), Santiago., Region M. De Santiago
Orlandi Oncologia ( Site 2555), Santiago, Region M. De Santiago
Clínica RedSalud Vitacura ( Site 2556), Santiago, Region M. De Santiago
Bradfordhill ( Site 2552), Santiago, Region M. De Santiago
ONCOCENTRO APYS ( Site 2554), Viña del Mar, Valparaiso
IMAT S.A.S ( Site 2602), Monteria, Cordoba
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2603), Bogota, Distrito Capital De Bogota
Hospital Universitario San Ignacio ( Site 2610), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 2604), Bogota, Distrito Capital De Bogota
Oncologos del Occidente ( Site 2608), Pereira, Risaralda
Fundacion Valle del Lili- CIC ( Site 2601), Cali, Valle Del Cauca
Oulun yliopistollinen sairaala ( Site 1301), Oulu, Pohjois-Pohjanmaa
Turku University Hospital ( Site 1303), Turku, Varsinais-Suomi
CHU Besançon ( Site 1358), Besancon, Franche-Comte
Institut De Cancerologie De L Ouest ( Site 1357), Saint Herblain, Loire-Atlantique
CENTRE LEON BERARD ( Site 1351), Lyon CEDEX 08, Rhone
Marienhaus Klinikum Mainz ( Site 1403), Mainz, Rheinland-Pfalz
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1452), Patras, Achaia
Errikos Dunant Hospital Center ( Site 1457), Athens, Attiki
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1451), Athens, Attiki
Metropolitan Hospital ( Site 1459), Athens, Attiki
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1460), Chaidari, Attiki
University General Hospital of Herakleion ( Site 1458), Herakleion., Irakleio
University General Hospital of Larissa-Oncology Clinic ( Site 1453), Larissa, Thessalia
Papageorgiou General Hospital of Thessaloniki ( Site 1454), Thessaloniki, Not set
Petz Aladár Megyei Oktató Kórház ( Site 1502), Gyor, Gyor-Moson-Sopron
Debreceni Egyetem Altalanos Orvostudomanyi Kar Tudogyogyaszati Tanszek ( Site 1508), Debrecen, Hajdu-Bihar
Mátrai Gyógyintézet ( Site 1504), Mátraháza, Heves
Reformatus Pulmonologiai Centrum-Onkopulmonologiai Jarobeteg Centrum ( Site 1505), Törökbálint, Pest
Somogy Vármegyei Kaposi Mór Oktató Kórház-Oncology center ( Site 1507), Kaposvár, Somogy
Orszagos Koranyi Pulmonologiai Intezet ( Site 1501), Budapest, Not set
Rambam Health Care Campus ( Site 1603), Haifa, Not set
Shaare Zedek Medical Center ( Site 1601), Jerusalem, Not set
Hadassah Medical Center ( Site 1605), Jerusalem, Not set
Sheba Medical Center ( Site 1602), Ramat Gan, Not set
Hospital of the University of Occupational and Environmental Health, Japan ( Site 1166), Kitakyushu, Fukuoka
St. Marianna University Hospital ( Site 1159), Kawasaki, Kanagawa
Kindai University Hospital ( Site 1162), Osakasayama, Osaka
National Cancer Center Hospital ( Site 1156), Chuo, Tokyo
Tokyo Medical University Hospital ( Site 1157), Shinjuku, Tokyo
Chiba University Hospital ( Site 1154), Chiba, Not set
National Hospital Organization Kyushu Cancer Center ( Site 1167), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 1151), Fukushima, Not set
Hiroshima University Hospital ( Site 1165), Hiroshima, Not set
Wakayama Medical University Hospital ( Site 1163), Wakayama, Not set
National Cancer Center ( Site 2305), Goyang-si, Kyonggi-do
The Catholic University of Korea St. Vincent s Hospital ( Site 2301), Suwonsi, Kyonggi-do
Ajou University Hospital ( Site 2306), Suwon, Kyonggi-do
Seoul National University Hospital ( Site 2303), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2302), Seoul, Not set
Samsung Medical Center ( Site 2304), Seoul, Not set
Seoul St. Mary's Hospital ( Site 2307), Seoul, Not set
Medisch Centrum Leeuwarden ( Site 1702), Leeuwarden, Fryslan
Radboudumc ( Site 1706), Nijmegen, Gelderland
Dunedin Hospital ( Site 2202), Dunedin, Otago
Aliada ( Site 2753), Lima, Not set
Detecta Clínica ( Site 2751), Lima, Not set
Krakowski Szpital Specjalistyczny im. Jana Pawla II ( Site 1756), Krakow, Malopolskie
Instytut Gruźlicy i Chorób Płuc w Warszawie ( Site 1764), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1759), Przemysl, Podkarpackie
Uniwersyteckie Centrum Kliniczne ( Site 1758), Gdansk, Pomorskie
Swietokrzyskie Centrum Onkologii. ( Site 1754), Kielce, Swietokrzyskie
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie ( Site 1760), Olsztyn, Warminsko-mazurskie
Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 1763), Poznan, Wielkopolskie
Centrul Medical Medicover Victoria ( Site 1802), Bucharest, Bucuresti
Institutul Regional de Oncologie ( Site 1804), Iasi, Not set
National Cancer Centre Singapore ( Site 2251), Singapore, Central Singapore
Tan Tock Seng Hospital ( Site 2252), Singapore, Central Singapore
Hospital Clinic de Barcelona ( Site 1919), Barcelona, Cataluna
Complejo Hospitalario Universitario A Coruna ( Site 1916), A Coruña, La Coruna
Hospital Universitario Quiron Madrid ( Site 1913), Pozuelo de Alarcon, Madrid
Hospital Insular de Gran Canaria ( Site 1911), Canarias, Not set
Hospital General Universitario Gregorio Maranon ( Site 1912), Madrid, Not set
Hospital Quiron Malaga ( Site 1914), Malaga, Not set
Karolinska Universitetssjukhuset Solna ( Site 1951), Stockholm, Stockholms Lan
Chung Shan Medical University Hospital ( Site 2351), Taichung, Not set
China Medical University Hospital ( Site 2358), Taichung, Not set
National Cheng Kung University Hospital ( Site 2354), Tainan, Not set
National Taiwan University Cancer Center (NTUCC) ( Site 2360), Taipei, Not set
Mackay Memorial Hospital ( Site 2355), Taipei, Not set
Taipei Medical University Hospital ( Site 2352), Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center ( Site 2359), Taipei, Not set
Taipei Veterans General Hospital ( Site 2357), Taipei, Not set
Chang Gung Memorial Hospital ( Site 2361), Taoyuan, Not set
Hacettepe Universite Hastaneleri ( Site 2001), Sıhhiye, Ankara
Namık Kemal University Medical Faculty ( Site 2007), Tekirdag, Tekirdas
Ankara Bilkent Sehir Hastanesi ( Site 2002), Ankara, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 2003), Istanbul, Not set
Bristol Haematology and Oncology Centre ( Site 2072), Bristol, Bristol, City Of
St Bartholomews Hospital ( Site 2052), London, London, City Of
Royal Free Hospital ( Site 2074), London, London, City Of
Guys Hospital ( Site 2057), London, London, City Of
Nottingham City Hospital ( Site 2058), Nottingham, Nottinghamshire
St James University Hospital ( Site 2055), Leeds, Not set
The Clatterbridge Cancer Centre ( Site 2069), Wirral, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
Active Not Recruiting
This study is being done to find out if zanidatamab, when given with chemotherapy plus or minus tislelizumab, is safe and works better than trastuzumab given with chemotherapy.
The patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esophageal cancers that are no longer treatable with surgery (unresectable) or chemoradiation, and/or have grown or spread to other parts of the body (metastatic).
This study is being done to find out if zanidatamab, when given with chemotherapy plus or minus tislelizumab, is safe and works better than trastuzumab given with chemotherapy.
The patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esophageal cancers that are no longer treatable with surgery (unresectable) or chemoradiation, and/or have grown or spread to other parts of the body (metastatic). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Hospital de Gastroenterología Dr Bonorino Udaondo, Buenos Aires, Not set +225 locations
Hospital de Gastroenterología Dr Bonorino Udaondo, Buenos Aires, Not set
Hospital Italiano de Buenos Aires, Buenos Aires, Not set
Instituto de Investigaciones Metabólicas - IDIM, Ciudad Autónoma de Buenos Aires, Not set
Fundación Centro de Medicina Nuclear y Molecular ER, Córdoba, Not set
Centro Médico Privado CEMAIC, Córdoba, Not set
Centro de Investigación Pergamino S.A., Pergamino, Not set
Centro de Investigación Clínica - Clínica Viedma, Viedma, Not set
Flinders Medical Centre, Bedford Park, Not set
Austin Health, Heidelberg, Not set
Liverpool Hospital, Liverpool, Not set
Fiona Stanley Hospital, Murdoch, Not set
Imelda VZW, Bonheiden, Not set
Cliniques Universitaires Saint-Luc, Brussels, Not set
UZ Gent, Gent, Not set
UZ Leuven, Leuven, Not set
CHU de Liège, Liège, Not set
Centro Integrado de Pesquisa - CIP, Barretos, Not set
Fundação Pio XII Hospital de Câncer de Barretos, Barretos, Not set
Cenantron - Centro Avancado de Tratamento Oncologico Ltda, Belo Horizonte, Not set
Centro de Pesquisas Clínicas/Fundação Doutor Amaral Carvalho, Brasília, Not set
Instituto Do Câncer Do Ceará ICC, Fortaleza, Not set
Hospital de Clinicas de Porto Alegre (HCPA) - PPDS, Porto Alegre, Not set
Irmandade Da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Hospital Nossa Senhora Da Conceição, Porto Alegre, Not set
Núcleo de Pesquisa Clínica da Rede São Camilo, Santo André, Not set
Instituto de Oncologia de Sorocaba, Sorocaba, Not set
Instituto do Cancer do Estado de São Paulo ICESP, São Paulo, Not set
Princess Margaret Cancer Centre, Toronto, Not set
Centro Internacional de Estudios Clinicos CIEC, Santiago, Region Metropolitan
Fundación Arturo López Pérez (FALP) - PPDS, Providencia, Región-Metropolitana De Santiago
Centro de Estudios Clínicos SAGA SpA, Providencia, Not set
Sociedad Oncovida S.A, Santiago, Not set
Icegclinic, Santiago, Not set
BIOCINETIC SpA, Santiago, Not set
Sociedad de Investigaciones Medicas Limitada, Temuco, Not set
Beijing Chao-Yang Hospital, Capital Medical University, Beijing, Not set
Cancer Hospital Chinese Academy of Medical Sciences, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
Peking University Third Hospital, Beijing, Not set
Beijing Luhe Hospital, Capital Medical University, Beijing, Not set
The First Affiliated Hospital of Bengbu Medical College, Bengbu, Not set
Hunan Cancer Hospital, Changsha, Not set
Changzhi People's Hospital, Changzhi, Not set
Changzhou First People's Hospital, Changzhou, Not set
Sichuan Cancer Hospital & Institute, Chengdu, Not set
The First Affiliated Hospital of Fujian Medical University, Fuzhou, Not set
Fujian Cancer Hospital, Fuzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Not set
Hainan General Hospital, Haikou, Not set
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Not set
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Not set
Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Anhui Provincial Cancer Hospital, Hefei, Not set
The Second Affiliated Hospital of Anhui Medical University, Hefei, Not set
Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Not set
Shandong Cancer Hospital, Jinan, Not set
Jinan Central Hospital, Jinan, Not set
Yunnan Cancer Hospital, Kunming, Not set
The First Hospital of Lanzhou University, Lanzhou, Not set
Gansu Cancer Hospital, Lanzhou, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Nanjing Drum Tower Hospital ,The Affiliated Hospital of Nanjing University Medical School, Nanjing, Not set
The Affiliated Hospital of Qingdao University, Qingdao, Not set
Ruijin hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Not set
Fudan University Affiliated Zhongshan Hospital, Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Shanghai General Hospital, Shanghai, Not set
Liaoning Cancer Hospital & Institute, Shenyang, Not set
The Fourth Hospital of Hebei Medical University, Shijiazhuang, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
The Tonghua Central Hospital, Tonghua, Not set
Weihai Municipal Hospital, Weihai, Not set
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set
Union Hospital Tongji Medical College HuaZhong University of Science and Technology, Wuhan, Not set
Hubei Cancer Hospital, Wuhan, Not set
Affiliated Hospital of Jiangnan University, Wuxi, Not set
First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an, Not set
The First Affiliated Hospital of Xiamen University, Xiamen, Not set
Northern Jiangsu People's Hospital, Yangzhou, Not set
Henan Cancer Hospital, Zhengzhou, Not set
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Not set
Cancer Hospital affiliated to Xinjiang Medical University, Ürümqi, Not set
North Estonia Medical Centre Foundation, Tallinn, Not set
CHU de Bordeaux - Hopital Haut Leveque, Pessac, Gironde
Sainte-Catherine, Institut du Cancer Avignon Provence, Avignon, Not set
EDOG - Institut Bergonie - PPDS, Bordeaux, Not set
Universite de Bourgogne - Faculte de Medecine - IN, Dijon, Not set
Centre Hospitalier Universitaire Grenoble Alpes - Hopital Albert Michallon, Grenoble, Not set
Centre Léon Berard, Lyon, Not set
EDOG Institut de Cancerologie de l'Ouest - PPDS, Nantes, Not set
CHRU de Poitiers La Miletrie, Poitiers, Not set
EDOG - Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer - PPDS, Rennes, Not set
CHRU de Brest - Hopital Morvan, Saint-Priest-en-Jarez, Not set
Hôpital de Rangueil, Toulouse, Not set
Hôpital Saint Antoine, Villejuif, Not set
Research Institute of Clinical Medicine, Tbilisi, Not set
High Technology Hospital MedCenter Ltd, Tbilisi, Not set
Institut für Klinisch-Onkologische Forschung, Frankfurt am Main, Hessen
Attikon University General Hospital, Athens, Not set
Bioclinic Thessaloniki Oncology Department, Thessaloniki, Not set
Agios Loucas Clinic SA, Thessaloniki, Not set
Interbalkan Medical Center of Thessaloniki Oncology Department, Thessaloniki, Not set
Clinica Medica Especializada CELAN, Guatemala City, Not set
Grupo Medico Angeles, Guatemala City, Not set
Centro Medico Integral de Cancerologia CEMIC, Salcaja, Not set
All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, Not set
Artemis Hospital, Gurgaon, Not set
MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Not set
Indraprastha Apollo Hospitals, New Delhi, Not set
Regional Cancer Centre Indira Gandhi Institute of Medical Sciences, Patna, Not set
HCG City Cancer Center, Vijayawada, Not set
St James's Hospital, Dublin, Not set
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi, Bologna, Not set
Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo, Not set
Ospedale Policlinico San Martino, Genova, Not set
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS, Meldola, Not set
Ospedale San Raffaele S.r.l. - PPDS, Milano, Not set
Istituto Nazionale Dei Tumori, Milano, Not set
ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda, Milano, Not set
Azienda Ospedaliero Universitaria Di Modena Policlinico, Modena, Not set
Arcispedale Santa Maria Nuova, Reggio Emilia, Not set
Fondazione Policlinico Universitario A Gemelli, Rome, Not set
Centro Ricerche Cliniche Di Verona, Verona, Not set
Azienda ULSS 8 "Berica" - Ospedale San Bortolo, Vicenza, Not set
Gifu University Hospital, Gifu-Shi, Gihu
Gunma Prefectural Cancer Center, Ota-shi, Gunma
Hyogo Cancer Center, Akashi-shi, Hyôgo
Ibaraki Prefectural Central Hospital, Kasama-Shi, Ibaraki
Kagawa University Hospital, Kita-Gun Miki-Cho, Kagawa
Kanagawa Cancer Center, Yokohama-Shi Asahi-Ku, Kanagawa
Kumamoto University Hospital - Honjo-Kuhonji Campus A, Chuo-Ku, Kumamoto
Kyoto University Hospital, Sakyo-ku, Kyoto-shi
Osaki Citizen Hospital, Osaki-Shi, Miyagi
Kurashiki Central Hospital, Kurashiki-Shi, Okayama
Osaka University Hospital, Suita-Shi, Osaka
Osaka Medical and Pharmaceutical University Hospital, Takatsuki-Shi, Osaka
Chiba Cancer Center, Chiba-Shi, Tiba
National Cancer Center Hospital East, Kashiwa-shi, Tiba
Keio University Hospital, Shinjuku-Ku, Tokyo
National Cancer Center Hospital, Chuo Ku, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Not set
Saitama Cancer Center, Ina, Not set
Shikoku Cancer Center, Matsuyama, Not set
Kindai University Hospital, Osaka-sayama, Not set
Osaka International Cancer Institute, Osaka, Not set
The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Tokyo, Not set
Hallym University Sacred Heart Hospital, Anyang-si, Not set
Dong-A University Hospital, Busan, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
National Cancer Center, Goyang-si, Not set
Gachon University Gil Medical Center, Incheon, Not set
CHA Bundang Medical Center, CHA University, Seongnam-si, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Kangbuk Samsung Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System - PPDS, Seoul, Not set
Asan Medical Center, Seoul, Not set
Gangnam Severance Hospital, Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Hospital Pulau Pinang, George Town, Not set
Sarawak General Hospital, Kuching, Not set
National Cancer Institute ( Institut Kanser Negara), Putrajaya, Not set
Health Pharma Professional Research S.A de C.V., Mexico City, Not set
Hospital Universitario Dr. Jose Eleuterio González, Monterrey, Not set
Centro de Investigacion Clinica de Oaxaca, Oaxaca, Not set
Catharina Hospital, Eindhoven, Not set
Leids Universitair Medisch Centrum, Leiden, Not set
ETZ-Elisabeth, Tilburg, Not set
Centrum Onkologii Instytut im. Marii Sklodowskiej-Curie, Warszawa, Not set
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Łódź, Not set
Hospital Garcia de Orta, Almada, Not set
Centro Hospitalar E Universitário de Coimbra EPE, Coimbra, Not set
Hospital Senhora da Oliveira - Guimaraes, E.P.E, Guimarães, Not set
Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisboa, Not set
Unidade Local de Saúde de Matosinhos SA, Matosinhos, Not set
Centro Hospitalar do Porto EPE, Porto, Not set
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Porto, Not set
Fundeni Clinical Institute, București, Not set
Prof Dr I Chiricuta Institute of Oncology - PPDS, Cluj-Napoca, Not set
Medisprof SRL, Cluj-Napoca, Not set
Oncology Center Sfantul Nectarie, Craiova, Not set
University Clinical Center of Serbia - PPDS, Belgrade, Not set
Clinical Hospital Center Bezanijska Kosa, Belgrade, Not set
University Clinical Center Nis, Niš, Not set
Oncology Institute of Vojvodina, Sremska Kamenica, Not set
National Cancer Center Singapore, Singapore, Not set
Wilgers Oncology Centre, Pretoria, Not set
Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona
Complejo Hospitalario de Navarra, Pamplona, Navarra
Hospital Universitario Germans Trias i Pujol, Badalona, Not set
Hospital Universitario Vall d'Hebron - PPDS, Barcelona, Not set
Hospital Universitari de Girona Dr Josep Trueta, Girona, Not set
Institut Català d'Oncologia (Hospital Duran y Reynals), L'Hospitalet de Llobregat, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario La Paz - PPDS, Madrid, Not set
Hospital Regional Universitario de Malaga - Hospital General, Málaga, Not set
Complejo Asistencial Universitario de Salamanca - H. Clinico, Salamanca, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
China Medical University Hospital, Taichung, Not set
Taipei Veterans General Hospital, Taipei, Not set
Songklanagarind Hospital, Hat Yai, Not set
Srinagarind Hospital, Khon Kaen University, Khon Kaen, Not set
Hacettepe Universitesi Kanser Enstitusu, Ankara, Not set
Trakya University Medical Faculty, Edirne, Not set
Dokuz Eylul Universitesi, Izmir, Not set
Acibadem Adana Hospital, Seyhan, Not set
Medical Park Trabzon Yildizli, Trabzon, Not set
Dr. Abdurrahman Yurtaslan Ankara Onkology Training and Research Hospital, Yenimahalle, Not set
The Municipal Enterprise Volyn Regional Medical Oncology Centre of the Volyn Regional Council, Lutsk, Not set
Bristol Haematology and Oncology Centre, Bristol, Not set
Western General Hospital Edinburgh - PPDS, Edinburgh, Not set
St James University Hospital, Leeds, Not set
Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital, London, Not set
Royal Marsden Hospital - London, London, Not set
Royal Marsden Hospital - Surrey, London, Not set
Edith Cavell Hospital, Peterborough, Not set
Weston Park Cancer Centre, Sheffield, Not set
Conditions: Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Recruiting
The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) inhibitor (physician's choice of either Durvalumab or Pembrolizumab, where approved under local regulations) as first line of treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive biliary tract cancer.
The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) inhibitor (physician's choice of either Durvalumab or Pembrolizumab, where approved under local regulations) as first line of treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive biliary tract cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Rocky Mountain Cancer Centers, LLP, Lone Tree, Colorado +173 locations
Rocky Mountain Cancer Centers, LLP, Lone Tree, Colorado
AdventHealth Hematology and Oncology, Orlando, Florida
Winship Cancer Institute, Atlanta, Georgia
The University of Kansas Cancer Center - Westwood, Westwood, Kansas
Norton Cancer Institute - Audubon, Louisville, Kentucky
Ochsner Clinic Foundation, New Orleans, Louisiana
Tufts Medical Center, Boston, Massachusetts
University of Michigan Hospital, Ann Arbor, Michigan
Henry Ford Health System, Detroit, Michigan
Minnesota Oncology Hematology, P.A., Maple Grove, Minnesota
Atlantic Health System/Morristown Medical Center, Morristown, New Jersey
Laura and Isaac Perlmutter Cancer Center at NYU Langone - Ambulatory Care Center, New York, New York
Memorial Sloan Kettering Cancer Centers, New York, New York
Saint Francis Cancer Center, Greenville, South Carolina
SCRI Oncology Partners, Nashville, Tennessee
Texas Oncology - DFW, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
The Univerrsity of Texas MD Anderson Cancer Center, Houston, Texas
Virginia Commonwealth University, VCU Health, Richmond, Virginia
Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires (CABA), Buenos Altes
Fundación ARS Médica, San Salvador De Jujuy, Jujuy
Centro de Investigaciónes Clínicas - Clínica Viedma, Viedma, Río Negro
Hospital Provincial Del Centenario, Rosario, Santa Fe
Instituto Médico de la Fundación Estudios Clínicos, Rosario, Santa Fe
CAIPO Centro para la Atención Integral del Paciente Oncológico, San Miguel De Tucumán, Tucumán
Centro Médico en Oncología Clínica EXELSUS S.R.L, San Miguel De Tucumán, Tucumán
Centro Médico Privado CEMAIC, Córdoba, Not set
Imelda VZW, Bonheiden, Antwerpen
UZ Antwerpen, Edegem, Antwerpen
UZ Leuven, Leuven, Vlaams-Brabant
Liga Norte Riograndense Contra O Cancer, Natal, Rio Grande Do Norte
Irmandade Da Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegrev, Rio Grande Do Sul
Hospital de Clinicas de Porto Alegre - HCPA, Porto Alegre, Rio Grande Do Sul
Fundação Pio XII Hospital de Amor de Barretos, Barretos, São Paulo
Fundação Doutor Amaral Carvalho - Hospital Amaral Carvalho, Jaú, São Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto (FUNFARME), São José do Rio Preto, São Paulo
Hospital Nossa Senhora Da Conceição/Centro Integrado de Pesquisa em Oncologia CIPO-GHC, Porto Alegre, Not set
Instituto Nacional de Cancer - INCA, Rio de Janeiro, Not set
London Health Sciences Centre, LondonO, Ontario
Princess Margaret Cancer Centre - University Health Network, Toronto, Ontario
James Lind Centro de Investigacion del Cancer, Temuco, Araucanía
Servicios Médicos URUMED SpA, Rancagua, Libertador Gen Bernardo O Higgins
Clinica Puerto Montt, Puerto Montt, Los Lagos
Fundación Arturo López Pérez (FALP), Santiago, Metropolitana
Oncovida, Santiago, Metropolitana
Hospital Clinico Universidad de Chile, Santiago, Region Metropolitana
Centro de Investigacion y Especialidades Medicas (CDIEM), Santiago, Región-Metropolitana
Biocinetic Ltda, Santiago, Región-Metropolitana
Hunan Provincial People's Hospital, Changsha, Hunan
Jilin Cancer Hospital, Changchun, Jilin
Shandong Provincial Third Hospital, Jinan, Shandong
Sichuan Cancer Hospital, Chengdu, Sichuan
Fakultní nemocnice Brno, Interní hematologická a onkologická klinika, Brno, Not set
Fakultni nemocnice Hradec Kralove, Klinika onkologie a radioterapie, Hradec Kralove, Not set
Fakultni nemocnice v Motole, Onkologicka klinika, Praha 5, Not set
Docrates Cancer Center, Helsinki, Not set
Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Not set
Kuopio University Hospital, Kuopio, Not set
CHU de Toulouse- (Toulouse University Hospital Center), Toulouse, Cedex 9
CHU Besancon, Besançon, Cedex
CHU de Bordeaux - Hôpital Haut Leveque, Pessac, Cedex
CHU Brest Hôpital de la Cavale Blanche, Brest, Not set
CHU Estaing, Clermont-Ferrand, Not set
Hospital Beaujon University, Clichy, Not set
Hopital Henri Mondor, Créteil, Not set
CHU Montepellier - Hôpital Saint Eloi, Montpellier, Not set
CHU Poitiers, Poitiers, Not set
Institut de Cancérologie de l'Ouest, Saint-Herblain Cedex, Not set
Gustave Roussy, Villejuif Cedex, Not set
Universitätsklinikum Tübingen - Medizinische Universitätsklinik, Innere Medizin I, Tuebingen, Baden-Wuttemberg
Universitätsklinikum Freiburg - Klinik für Innere Medizin II,, Freiburg, Baden-Württemberg
Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg, Heidelberg, Baden-Württemberg
LMU Universitätsklinikum München, Campus Großhadern, Medizinische Klinik und Poliklinik III - Hämatologie und Onkologie, München, Bayern
Krankenhaus Nordwest - Institut für Klinisch-Onkologische Forschung (IFK), Frankfurt, Hessen
Medizinische Hochschule Hannover - Klinik Fur Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie, Hannover, Nieder-Sachsen
Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus, Dresden, Sachsen
Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Medizinische Klinik I (MKI), Lubeck, Schleswig-Holstein
Charité - Universitätsmedizin Berlin - Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt Hamatologie und Tumorimmunologie, Berlin, Not set
Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona - Onkologie und Palliativmedizin mit Sektionen Hamatologie und Rheumatologie, Hamburg, Not set
KLES Dr Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka
Tata Memorial Hospital, Mumbai, Maharashtra
Chopda Medicare & Research Centre Pvt. Ltd - Magnum Heart Institute, Nashik, Maharashtra
AIG Hospitals (A Unit of Asian Institute of Gastroenterology), Hyderabad, Telangana
Pi Health Cancer Hospital, Hyderabad, Telangana
Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, Uttar Pradesh
Max Super Speciality Hospital - Saket (a unit of Devki Devi foundation), New Delhi, Not set
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Not set
Rambam Health Care Campus, Haifa, Not set
The Hadassah University Medical Center, Ein Kerem Hospital, Jerusalem, Not set
Rabin Medical Center, Bellinson Hospital, Petah-Tikva, Not set
The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, HaMerkaz, Not set
Tel Aviv Sourasky Medical Center (Ichilov), Tel Aviv, Not set
Azienda Ospedaliero Universitaria di Cagliari Presidio Ospedaliero Duilio Casula, Monserrato, Cagliari
Instituo di Candiolo, Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo, Torino
IRCCS Ospedale Policlinico San Martino, Genova, Not set
Fondazione IRCCS Istituto Nazionale per lo studio e la cura dei Tumori, Milano, Not set
AOU dell'Universit~ degli Studi della Campania Luigi Vanvitelli, Napoli, Not set
Veneto Institute of Oncology IOV - I.R.C.C.S., Padova, Not set
Azienda Ospedaliero - Universitaria Pisana, Pisa, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Azienda Sanitaria Universitaria Friuli Centrale - P.O. S. Maria della Misericordia, Udine, Not set
Azienda Ospedaliera Universitaria Integrata Verona, Verona, Not set
Aichi Cancer Center, Nagoya-shi, Aichi
Chiba Cancer Center, Chiba-shi, Chiba
National Cancer Center Hospital East, Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center, Matsuyama-Shi, Ehime
National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Fukuoka
Hokkaido University Hospital, Sapporo-Shi, Hokkaidô
Kanazawa University Hospital, Kanazawa-shi, Isikawa
Kagoshima University Hospital, Kagoshima-shi, Kagoshima
Kanagawa Cancer Center, Yokohama-shi, Kanagawa
Kyoto University Hospital, Kyoto City, Kyôto
Mie University Hospital, Tsu-Shi, Mie
Tohoku University Hospital, Sendai-Shi, Miyagi
Niigata University Medical and Dental Hospital, Niigata-shi, Niigata
Osaka Prefectural Hospital Organization Osaka International Cancer Institute, Osaka-shi, Osaka
The University of Tokyo Hospital, Bunkyo-ku, Tokyo
National Cancer Center Hospital, Chuo-Ku, Tokyo
The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Koto-Ku, Tokyo
Kyorin University Hospital, Mitaka-shi, Tokyo
Yamaguchi University Hospital, Ube-Shi, Yamaguchi
Osaka University Hospital, Suita-Shi, Ôsaka
CHA Bundang Medical Center, CHA University, Bundang-Gu, Seongnam-Si, Gyeonggi-do
National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do
Pusan National University Hospital, Busan, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Hanyang University Seoul Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Unidade Local de Saude de Almada-Seixal, E.P.E. - Hospital Garcia de Orta, Almada, Not set
Unidade Local de Saude de Coimbra, EPE - Hospitais da Universidade de Coimbra, Coimbra, Not set
Unidade Local de Saúde de São José - Hospital de Santo António dos Capuchos, Lisboa, Not set
Champalimaud Clinical Center, Lisboa, Not set
Instituto Português de Oncologia Do Porto Francisco Gentil, EPE, Porto, Not set
Hospital Oncologico, Puerto Rico Medical Center, Rio Piedras, Not set
Spital Clinic Judetean de Urgenta Bihor, Oradea, Bihor
Centrul De Oncologie "SF. Nectarie" S.R.L., Craiova, Dolj
Institutul Clinic Fundeni, Bucharest, Not set
Centrul de Oncologie Euroclinic SRL, Iasi, Not set
University Clinical Center of Serbia, Clinic for Gastroenterohepatology, Belgrade, Not set
Military Medical Academy, Clinic for Gastroenterology and Hepatology, Belgrade, Not set
Oncology Institute of Vojvodina, Internal Oncology Clinic, Sremska Kamenica, Not set
Complejo Hospitalario Universitario de Santiago -Hospital Clinico Universitario de Santiago, Santiago de Compostela, A Coruna
Vall d'Hebron Institute of Oncology/Hospital Universitari de Vall d'Hebron, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Malaga, Malaga, Not set
Clinica Universidad de Navarra, Pamplona, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario y Politecnico La Fe, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Onkologiska mottagningen, Sahlgrenska Universitetssjukhuset, Göteborg, Not set
Cancerstudieenheten Huddinge, Karolinska Universitetssjukhuset Huddinge, Huddinge, Not set
Onkologiska mottagningen, Skånes Universitetssjukhus Malmö, Malmö, Not set
Kaohsiung Medical University - Chung-Ho Memorial Hospital, Kaohsiung, Not set
Chang Gung Memorial Hospital Kaohsiung Branch of the Chang Gung Medical Foundation, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Cancer Center, Taipei, Not set
Chang Gung Memorial Hospital Linkou Branch of the Chang Gung Medical Foundation, Taoyuan, Not set
Istanbul University Cerrahpasa Medical Faculty Hospital/Clinical Research Center, Istanbul, Fatih
Hacettepe University Cancer Institute, Ankara, Sihhiye
Akdeniz University Medical Faculty Hospital, Antalya, Not set
Trakya University Faculty of Medicine, Edirne, Not set
Mount Vernon Cancer Centre, London, England
NHS Foundation Trust Royal Marsden Hospital, London, England
The Christie NHS Foundation Trust, Manchester, England
Royal Marsden Hospital NHS Foundation Trust, Surrey, England
Western General Hospital, Edinburgh Cancer Centre, Edinburgh, Scotland
Conditions: Biliary Tract Cancer
A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
Recruiting
This phase II trial tests effects of nivolumab in combination with chemotherapy drugs prior to radiation therapy patients with nasopharyngeal carcinoma (NPC). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping the... Read More
This phase II trial tests effects of nivolumab in combination with chemotherapy drugs prior to radiation therapy patients with nasopharyngeal carcinoma (NPC). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Researchers want to find out what effects, good and/or bad, adding nivolumab to chemotherapy has on patients with newly diagnosed NPC. In addition, they want to find out if children with NPC may be treated with less radiation therapy and whether this decreases the side effects of therapy. Read Less
Gender:
ALL
Ages:
21 years and below
Trial Updated:
07/29/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +59 locations
Children's Hospital of Alabama, Birmingham, Alabama
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Nicklaus Children's Hospital, Miami, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Children's Hospital New Orleans, New Orleans, Louisiana
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Hackensack University Medical Center, Hackensack, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Albany Medical Center, Albany, New York
East Carolina University, Greenville, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Prisma Health Richland Hospital, Columbia, South Carolina
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Children's Hospital of San Antonio, San Antonio, Texas
University of Virginia Cancer Center, Charlottesville, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Seattle Children's Hospital, Seattle, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Starship Children's Hospital, Grafton, Auckland
Conditions: Stage II Nasopharyngeal Carcinoma AJCC v8, Stage III Nasopharyngeal Carcinoma AJCC v8, Stage IV Nasopharyngeal Carcinoma AJCC v8
Low-Dose Weekly vs High-Dose Cisplatin
Recruiting
This study is a prospective open-label randomized clinical trial. Following informed consent eligible LASCCHN patients (n=100) planned for CRT will be stratified by tumor p16 status and then randomized in a 1:1 fashion to either concurrent HD cisplatin or concurrent weekly LD cisplatin.
This study is a prospective open-label randomized clinical trial. Following informed consent eligible LASCCHN patients (n=100) planned for CRT will be stratified by tumor p16 status and then randomized in a 1:1 fashion to either concurrent HD cisplatin or concurrent weekly LD cisplatin. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Juravinski Cancer Centre, Hamilton, Ontario +2 locations
Juravinski Cancer Centre, Hamilton, Ontario
London Regional Cancer Program, London, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment
Recruiting
This study is open to adults 18 years and older with advanced or metastatic non-small cell lung cancer. People can join the study if they have tumours with HER2 mutations and have not yet received any systemic therapy including chemotherapy for advanced or metastatic lung cancer. The purpose of this study is to find out whether a medicine called zongertinib (BI 1810631) can slow down the worsening of advanced non-small cell lung cancer better than the standard treatment available. Zongertinib ma... Read More
This study is open to adults 18 years and older with advanced or metastatic non-small cell lung cancer. People can join the study if they have tumours with HER2 mutations and have not yet received any systemic therapy including chemotherapy for advanced or metastatic lung cancer. The purpose of this study is to find out whether a medicine called zongertinib (BI 1810631) can slow down the worsening of advanced non-small cell lung cancer better than the standard treatment available. Zongertinib may slow cancer cell growth by inhibiting HER2. This would prolong cancer re-occurrence and increase survival. Current standard treatment is pembrolizumab plus platinum-pemetrexed chemotherapy.
Participants are put into 2 groups by chance. One group receives zongertinib at regular times throughout the study and the other group receives infusions of pembrolizumab, pemetrexed and cisplatin or carboplatin (pembrolizumab plus platinum-pemetrexed chemotherapy) into a vein.
Participants may be in the study up to a maximum of 70 months. During this time, they visit the study site about every 3 weeks for study procedures. The doctors regularly check the size of the tumour with a CT or MRI scan, at the beginning of the study and every 6 weeks. After 18 months they check the tumour size every 12 weeks. Doctors regularly check whether the cancer has spread to other parts of the body. The doctors also regularly check participants' health and take note of any unwanted effects. The time it takes for the cancer to worsen is compared between the 2 groups to see whether the treatment works. The participants also fill in questionnaires about their symptoms and quality of life. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Clearview Cancer Institute, Huntsville, Alabama +169 locations
Clearview Cancer Institute, Huntsville, Alabama
Mohtaseb Cancer Center and Blood Disorders, LLC, Bullhead City, Arizona
Precision NextGen Oncology, Beverly Hills, California
ClinRé 001-022 (Premier Cancer Care and Infusion Center), Fresno, California
OPN Healthcare, Inc., Glendale, California
Scripps Green Hospital, La Jolla, California
Valkyrie Clinical Trials, Los Angeles, California
Sharp Memorial Hospital, San Diego, California
St. Louis Cancer Care, LLP, Bridgeton, Missouri
Oncology Hematology Associates, Springfield, Missouri
Cancer Care Specialists, Reno, Nevada
Montefiore Medical Center, Bronx, New York
Northwell Health, Lake Success, New York
Regional Medical Oncology Center, Wilson, North Carolina
Gabrail Cancer Center, Canton, Ohio
Carolina Blood and Cancer Care Associates, PA, Rock Hill, South Carolina
SCRI Oncology Partners, Nashville, Tennessee
Huntsman Cancer Institute, Salt Lake City, Utah
Virginia Cancer Specialists, PC, Fairfax, Virginia
Swedish Cancer Institute, Edmonds, Washington
Swedish Cancer Institute, Issaquah, Washington
Swedish Cancer Institute, Seattle, Washington
Clinica Adventista Belgrano, Caba, Not set
Instituto Medico Especializado Alexander Fleming, Ciudad Autónoma de Bs As, Not set
Instituto Oncologico de Cordoba, Córdoba, Not set
Centro Oncologico Riojano Integral (CORI), La Rioja, Not set
Instituto Médico de la Fundación Estudios Clínicos, Rosario, Not set
Clinicas Viedma S.A., Viedma, Not set
Prince of Wales Hospital-Randwick-66496, Randwick, New South Wales
Royal North Shore Hospital-St Leonards-20807, St Leonards, New South Wales
Princess Alexandra Hospital, Woolloongabba, Queensland
Austin Health, Heidelberg, Victoria
St John of God Subiaco Hospital, Subiaco, Western Australia
Krems University Hospital, Krems an der Donau, Not set
Clinic Floridsdorf, Vienna, Not set
Brussels - HOSP Jules Bordet, Anderlecht, Not set
UNIV UZ Gent, Gent, Not set
UZ Leuven, Leuven, Not set
Associacao Dr. Bartholomeu Tacchini, Bento Goncalves, Not set
Hospital do Cancer de Londrina, Londrina, Not set
Hospital Sao Lucas da PUCRS, Porto Alegre, Not set
OncoClinicas Rio de Janeiro, Rio de Janeiro, Not set
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo André, Not set
ICESP - Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
Bradford Hill- Centro de Investigación Clínica, Recoleta, Not set
Cancer Hospital of Chinese Academy of Medical Science, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
West China Hospital of Sichuan University, Chengdu, Not set
Fujian Cancer Hospital, Fuzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The First Affiliated Hospital, Zhejiang University, Hangzhou, Not set
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Zhongshan Hospital Affiliated to Fudan University, Shanghai, Not set
Taizhou Hospital of Zhejiang Province, Taizhou, Not set
The First Affiliated Hospital of Wenzhou Med College, Wenzhou, Not set
Wuhan Union Hospital, Wuhan, Not set
First Affiliated Hospital of Xiamen University, Xiamen, Not set
Henan Cancer Hospital, Zhengzhou, Not set
HOP Louis Pradel, Bron, Not set
CTR Leon Berard, Lyon, Not set
HOP Nord, Marseille, Not set
HOP Tenon, Paris, Not set
INS Curie, Paris, Not set
HOP Pontchaillou, Rennes, Not set
HOP Civil, Strasbourg, Not set
INS Claudius Regaud IUCT-Oncopole, Toulouse, Not set
INS Gustave Roussy, Villejuif, Not set
Universitätsklinikum Augsburg, Augsburg, Not set
Gemeinschaftskrankenhaus Havelhöhe gGmbH, Berlin, Not set
Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Justus-Liebig Universität Gießen, Gießen, Not set
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg, Heidelberg, Not set
Universitätsklinikum Köln (AöR), Köln, Not set
Pius-Hospital, Oldenburg, Oldenburg, Not set
Universitätsklinikum Tübingen, Tübingen, Not set
Queen Elizabeth Hospital-Hong Kong-51727, Hong Kong, Not set
Princess Margaret Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Koranyi National Institute For Pulmonolgy, Budapest, Not set
National Institute of Oncology, Budapest, Not set
Deszk Hospital of Chest Diseases, Deszk, Not set
Pulmonology Institute of Veszprem County, Farkasgyepu, Farkasgyepu, Not set
Fejer County Saint George University Teaching Hospital, Szekesfehervar, Not set
Rambam Medical Center, Haifa, Not set
Meir Medical Center, Kfar-Saba, Not set
Rabin Medical Center Beilinson, Petach Tikva, Not set
Sourasky Medical Center, Tel Aviv, Not set
Istituto Tumori Giovanni Paolo II, Bari, Not set
Istituto Di Candiolo, Candiolo (TO), Not set
AOU Policlinico G. Rodolico San Marco, Catania, Not set
Istituto Nazionale IRCCS Tumori Fondazione Pascale, Napoli, Not set
Azienda Ospedaliera Unversitaria di Parma, Parma, Not set
AOU Policlinico Umberto I, Roma, Not set
A. O. Ospedale Circolo Fond. Macchi, Varese, Not set
Aichi Cancer Center Hospital, Aichi, Nagoya, Not set
Hirosaki University Hospital, Aomori, Hirosaki, Not set
National Cancer Center Hospital East, Chiba, Kashiwa, Not set
Shikoku Cancer Center, Ehime, Matsuyama, Not set
Kyushu University Hospital, Fukuoka, Fukuoka, Not set
Hakodate Goryoukaku Hospital, Hokkaido, Hakodate, Not set
Hokkaido Cancer Center, Hokkaido, Sapporo, Not set
Kanazawa University Hospital, Ishikawa, Kanazawa, Not set
St. Marianna University Hospital, Kanagawa, Kawasaki, Not set
Kanagawa Cancer Center, Kanagawa, Yokohama, Not set
University Hospital Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Not set
Tohoku University Hospital, Miyagi, Sendai, Not set
Okayama University Hospital, Okayama, Okayama, Not set
Osaka International Cancer Institute, Osaka, Osaka, Not set
Shizuoka Cancer Center, Shizuoka, Sunto-gun, Not set
Juntendo University Hospital, Tokyo, Bunkyo-ku, Not set
Komagome Hospital, Tokyo, Bunkyo-ku, Not set
National Cancer Center Hospital, Tokyo, Chuo-ku, Not set
Japanese Foundation for Cancer Research, Tokyo, Koto-ku, Not set
Wakayama Medical University Hospital, Wakayama, Wakayama, Not set
Chungbuk National University Hospital, Cheongiu, Not set
National Cancer Center, Goyang, Not set
Gachon University Gil Medical Center, Incheon, Not set
Kangbuk Samsung Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, St.Vincent's Hospital, Suwon, Not set
Health Pharma Professional Research S.A. de C.V., Ciudad de Mexico, Not set
Centro Oncologico Personalizado, Mexico, Not set
Instituto Nacional de Cancerologia, Mexico, Not set
FAICIC S de RL de C.V., Veracruz, Not set
Nederlands Kanker Instituut - Antoni van Leeuwenhoek Amsterdam (METC AVL), Amsterdam, Not set
Maastricht University, Maastricht, Not set
Vestre Viken HF, Drammen Sykehus, Drammen, Not set
Oslo Universitetssykehus HF, Radiumhospitalet, Oslo, Not set
Polish Mother's Memorial Hospital - Research Institute, Lodz, Not set
Greater Poland Center of Pulmonology and Thoracic Surgery, Poznan, Not set
MED POLONIA SP Z O O, Clinical Trials Department,Poznan, Poznan, Not set
Oncology Center-Maria Sklodowska-Curie Institute, Warsaw, Not set
Hospital CUF Tejo, Lisboa, Not set
Centro Hospitalar Lisboa Norte Hospital Pulido Valente, Lisboa, Not set
Hospital CUF Porto, Porto, Not set
Pan American Center for Oncology Trials, LLC, Rio Piedras, Not set
National University Hospital-Singapore-22806, Singapore, Not set
National Cancer Centre Singapore, Singapore, Not set
Hospital A Coruña, A Coruña, Not set
Hospital General Universitario de Alicante, Alicante, Not set
Hospital Santa Creu i Sant Pau, Barcelona, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Hospital de Basurto, Bilbao, Not set
Hospital Duran i Reynals, L'Hospitalet de Llobregat, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital La Paz, Madrid, Not set
Hospital Regional Universitario de Málaga, Málaga, Not set
Hospital Virgen del Rocío, Sevilla, Not set
Hospital Clínico de Valencia, Valencia, Not set
Sahlgrenska Universitetsjukhuset, Göteborg, Not set
Karolinska Universitetssjukhuset Solna, Stockholm, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Chung Shan Medical University Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
National Taiwan University Cancer Center, Taipei, Not set
Chang Gung Memorial Hospital(Linkou), Taoyuan, Not set
Western General Hospital, Edinburgh, Not set
Leicester Royal Infirmary, Leicester, Not set
Guy's Hospital, London, Not set
The Royal Marsden Hospital, Chelsea, London, Not set
The Royal Marsden Hospital, Sutton, Sutton, Not set
Conditions: Lung Cancer, Non-squamous, Non-small Cell
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Recruiting
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR).
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060), Little Rock, Arkansas +219 locations
UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060), Little Rock, Arkansas
Highlands Oncology Group-Research Department ( Site 0062), Springdale, Arkansas
Beverly Hills Cancer Center ( Site 0070), Beverly Hills, California
The Angeles Clinic and Research Institute ( Site 0040), Los Angeles, California
The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate ( Site 0079), Los Angeles, California
San Francisco Oncology Associates ( Site 0066), San Francisco, California
Stamford Hospital ( Site 0083), Stamford, Connecticut
Mount Sinai Cancer Center ( Site 0038), Miami Beach, Florida
Mid Florida Hematology and Oncology Center ( Site 0018), Orange City, Florida
Emory University School of Medicine-Phase I ( Site 0056), Atlanta, Georgia
Northside Hospital ( Site 0055), Atlanta, Georgia
Centricity Research Columbus Cancer Center ( Site 0005), Columbus, Georgia
Lewis Cancer and Research Pavilion ( Site 0063), Savannah, Georgia
Archbold Cancer Center ( Site 0071), Thomasville, Georgia
Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0017), Elmhurst, Illinois
Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0078), Naperville, Illinois
Parkview Research Center at Parkview Regional Medical Center ( Site 0089), Fort Wayne, Indiana
Indiana University Health Arnett Cancer Center ( Site 0076), Lafayette, Indiana
Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0061), Edgewood, Kentucky
Our Lady of the Lake Physician Group-Medical Oncology ( Site 0080), Baton Rouge, Louisiana
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0027), Minneapolis, Minnesota
Mercy Research - David C. Pratt Cancer Center ( Site 0006), Saint Louis, Missouri
Renown Regional Medical Center-Renown Health Medical Oncology ( Site 0037), Reno, Nevada
Atlantic Health Morristown Medical Center ( Site 0077), Morristown, New Jersey
Stony Brook University-Cancer Center ( Site 0054), Stony Brook, New York
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0057), Fargo, North Dakota
Oregon Health and Science University ( Site 0052), Portland, Oregon
Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0068), Lancaster, Pennsylvania
Medical University of South Carolina-Hollings Cancer Center ( Site 0045), Charleston, South Carolina
Sanford Cancer Center ( Site 0053), Sioux Falls, South Dakota
Avera Cancer Institute- Research ( Site 0090), Sioux Falls, South Dakota
University of Tennessee Medical Center Knoxville ( Site 0082), Knoxville, Tennessee
Millennium Research & Clinical Development ( Site 0039), Houston, Texas
Huntsman Cancer Institute ( Site 0042), Salt Lake City, Utah
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0213), Ciudad Autonoma de Buenos Aires, Buenos Aires
Hospital Británico de Buenos Aires-Oncology ( Site 0207), Ciudad autónoma de Buenos Aires, Buenos Aires
Sanatorio Británico-Clinical Oncology Department ( Site 0206), Rosario, Santa Fe
Sanatorio Parque ( Site 0205), Rosario, Santa Fe
Hospital Aleman-Oncology ( Site 0202), Buenos Aires, Not set
Hospital Privado Universitario de Córdoba-Hematology and Oncology ( Site 0204), Cordoba, Not set
Westmead Hospital ( Site 0701), Westmead, New South Wales
The Prince Charles Hospital ( Site 0700), Brisbane, Queensland
Fiona Stanley Hospital-Medical Oncology ( Site 0705), Murdoch, Western Australia
Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 1402), Linz, Oberosterreich
Medizinische Universitaet Innsbruck-Department for Internal Medicine V ( Site 1403), Innsbruck, Tirol
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 1400), Wien, Not set
Antwerp University Hospital-Thoracic Oncology ( Site 1503), Edegem, Antwerpen
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi ( Site 1502), Yvoir, Namur
VITAZ ( Site 1500), Sint-Niklaas, Oost-Vlaanderen
Liga Norte Riograndense Contra o Câncer ( Site 0301), Natal., Rio Grande Do Norte
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0303), Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceição ( Site 0302), Porto Alegre, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 0319), Santa Cruz do Sul, Rio Grande Do Sul
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0304), Barretos, Sao Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0313), São José do Rio Preto, Sao Paulo
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0100), Greenfield Park, Quebec
St. Marys Hospital Center ( Site 0107), Montreal, Quebec
Centre Hospitalier de l'Université de Montréal ( Site 0104), Montréal, Quebec
FALP-UIDO ( Site 0401), Providencia, Region M. De Santiago
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 0404), Santiago., Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0400), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0410), Viña del Mar, Valparaiso
Beijing Cancer hospital-Thoracic Surgery department I ( Site 1301), Beijing, Beijing
Beijing Peking Union Medical College Hospital-Thoracic surgery department ( Site 1302), Beijing, Beijing
Peking University People's Hospital. ( Site 1300), Beijing, Beijing
Fujian Cancer Hospital-oncology department ( Site 1314), Fuzhou, Fujian
The First Affiliated Hospital of Guangzhou Medical University-thoracic surgery department ( Site 1320), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital-Thoracic surgery department ( Site 1313), Guangzhou, Guangdong
Henan Cancer Hospital-henan cancer hospital ( Site 1316), Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology-Thoracic Surgery ( Site 1306), Wuhan, Hubei
Hubei Cancer Hospital ( Site 1308), Wuhan, Hubei
Xiangya Hospital Central South University-Thoracic surgery ( Site 1311), Changsha, Hunan
Hunan Cancer Hospital ( Site 1312), Changsha, Hunan
Nanjing First Hospital ( Site 1310), Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University-Thoracic Surgery Department ( Site 1318), Suzhou, Jiangsu
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 1330), Nanchang, Jiangxi
The First Hospital of Jilin University ( Site 1324), Changchun, Jilin
The Second Affiliated Hospital of Air Force Medical University ( Site 1332), Xian, Shaanxi
Shandong Cancer Hospital ( Site 1321), Jinan, Shandong
Zhongshan Hospital Fudan University ( Site 1325), Shangai, Shanghai
Shanghai Pulmonary Hospital-Thoracic Surgery department ( Site 1304), Shanghai, Shanghai
Sichuan Cancer hospital. ( Site 1327), Chengdu, Sichuan
The Second People's Hospital of Neijiang ( Site 1322), Neijiang, Sichuan
Yunnan Province Cancer Hospital ( Site 1315), Kunming, Yunnan
The first Affiliated Hospital, Zhejiang University School of-Thoracic Cardiovascular Surgery Ward ( Site 1303), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 1309), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 1328), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 1329), Linhai, Zhejiang
Ningbo No. 2 Hospital ( Site 1305), Ningbo, Zhejiang
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 1600), Brno, Brno-mesto
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 1601), Ostrava, Ostrava Mesto
CHRU de Brest ( Site 1804), Brest, Finistere
CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 1801), Toulouse, Haute-Garonne
CHU Charles Nicolle ( Site 1803), Rouen, Haute-Normandie
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1805), Limoges, Haute-Vienne
Groupe hospitalier Paris saint Joseph. ( Site 1807), Paris, Ile-de-France
Clinique Teissier Groupe ( Site 1811), Valenciennes, Nord
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1810), Clermont-Ferrand, Puy-de-Dome
Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1809), Bron, Rhone
HIA Sainte Anne ( Site 1800), Toulon, Var
Hôpital Tenon ( Site 1802), Paris, Not set
Klinikum Esslingen-Klinik für Kardiologie und Pneumologie ( Site 1914), Esslingen, Baden-Wurttemberg
Katholisches Klinikum Koblenz ( Site 1911), Koblenz, Rheinland-Pfalz
Krankenhaus Martha-Maria Halle-Dölau-Klinik für Innere Medizin II ( Site 1908), Halle, Sachsen-Anhalt
Universitätsklinikum Leipzig ( Site 1915), Leipzig, Sachsen
SRH Wald-Klinikum Gera-Lungenkrebszentrum ( Site 1900), Gera, Thuringen
Vivantes Hospital Spandau-Klinik für Innere Medizin, Hämatologie, Onkologie und Gastroenterologie- ( Site 1912), Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf ( Site 1916), Berlin, Not set
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 2006), Patras, Achaia
251 Hellenic Air Force General Hospital ( Site 2003), Athens, Attiki
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 2000), Athens, Attiki
Athens Medical Center ( Site 2005), Athens, Attiki
Metaxa Cancer Hospital of Piraeus ( Site 2002), Piraeus, Attiki
University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 2001), Heraklion, Irakleio
University General Hospital of Larissa-Oncology Clinic ( Site 2004), Larissa, Thessalia
European Interbalkan Medical Center ( Site 2007), Thessaloniki, Not set
Queen Mary Hospital ( Site 3400), Hksar, Not set
Hong Kong United Oncology Centre ( Site 3403), Kowloon, Not set
Queen Elizabeth Hospital ( Site 3402), Yau Ma Tei, Not set
Rambam Health Care Campus-Oncology Division ( Site 2203), Haifa, Not set
Shaare Zedek Medical Center ( Site 2206), Jerusalem, Not set
Rabin Medical Center ( Site 2204), Petah Tikva, Not set
Sheba Medical Center ( Site 2200), Ramat Gan, Not set
Humanitas Istituto Clinico Catanese ( Site 2315), Misterbianco, Catania
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 2302), Meldola, Emilia-Romagna
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 2300), Milan, Lombardia
Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 2301), Monza, Lombardia
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 2309), Rome, Roma
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 2307), Firenze, Toscana
Humanitas Gavazzeni-ONCOLOGY ( Site 2310), Bergamo, Not set
Ospedale San Martino ( Site 2313), Genova, Not set
Ospedale San Raffaele-Oncologia Medica ( Site 2311), Milano, Not set
Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 2312), Parma, Not set
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 2303), Pavia, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 2306), Roma, Not set
APSS- Presidio Ospedaliero S. Chiara ( Site 2304), Trento, Not set
National Hospital Organization Shikoku Cancer Center ( Site 1216), Matsuyama, Ehime
Hospital of the University of Occupational and Environmental Health, Japan ( Site 1217), Kitakyushu, Fukuoka
Kobe City Medical Center General Hospital ( Site 1213), Kobe, Hyogo
St. Marianna University Hospital ( Site 1207), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 1206), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 1211), Hirakata, Osaka
Kindai University Hospital ( Site 1212), Osakasayama, Osaka
Saitama Prefectural Cancer Center ( Site 1201), Kitaadachi-gun, Saitama
Juntendo University Hospital ( Site 1204), Bunkyo-ku, Tokyo
Tokyo Medical University Hospital ( Site 1203), Shinjuku, Tokyo
National Hospital Organization Kyushu Cancer Center ( Site 1218), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 1200), Fukushima, Not set
Hiroshima University Hospital ( Site 1215), Hiroshima, Not set
Niigata Cancer Center Hospital ( Site 1208), Niigata, Not set
Okayama University Hospital ( Site 1214), Okayama, Not set
Osaka International Cancer Institute ( Site 1210), Osaka, Not set
Nippon Medical School Hospital ( Site 1205), Tokyo, Not set
Chungbuk National University Hospital-Internal medicine ( Site 1000), Cheongju-si, Chungbuk
National Cancer Center-Lung Cancer Center ( Site 1002), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital-Medical Oncology ( Site 1003), Seongnam, Kyonggi-do
The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 1001), Suwon-si, Kyonggi-do
Keimyung University Dongsan Hospital CRC room 1 ( Site 1006), Daegu, Taegu-Kwangyokshi
Asan Medical Center-Lung Cancer Center ( Site 1005), Seoul, Not set
Samsung Medical Center-Division of Hematology/Oncology ( Site 1004), Seoul, Not set
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0506), Guadalajara, Jalisco
Centro de Investigacion Clinica de Oaxaca ( Site 0509), Oaxaca de Juarez, Oaxaca
Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 0504), Chihuahua, Not set
Mediadvance Clinical ( Site 0502), Chihuahua, Not set
Oaxaca Site Management Organization S.C. ( Site 0507), Oaxaca, Not set
Amphia Ziekenhuis, locatie Breda Molengracht-long oncologie ( Site 3453), Breda, Noord-Brabant
Isala, locatie Zwolle-Poli Longziekten ( Site 3454), Zwolle, Overijssel
Meander Medisch Centrum-Researchbureau Longgeneeskunde ( Site 3458), Amersfoort, Utrecht
Erasmus Medisch Centrum ( Site 3452), Rotterdam, Zuid-Holland
University Medical Center Groningen ( Site 3459), Groningen, Not set
Sint Antonius Ziekenhuis ( Site 3455), Utrecht, Not set
Auckland City Hospital ( Site 0800), Auckland, Not set
Akershus Universitetssykehus ( Site 2501), Lørenskog, Akershus
Drammen Sykehus, Vestre Viken HF ( Site 2502), Drammen, Buskerud
Sykehuset Innlandet HF Gjøvik ( Site 2503), Gjøvik, Oppland
Oslo universitetssykehus HF. Radiumhospitalet ( Site 2504), Oslo, Not set
IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 0604), Lima, Not set
Oncosalud ( Site 0602), Lima, Not set
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 0600), Lima, Not set
Instituto Neuro Cardiovascular de las Americas ( Site 0607), Lima, Not set
Hospital Nacional Edgardo Rebagliati Martins-medical oncology ( Site 0603), Lima, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2600), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2601), Przemysl, Podkarpackie
Bialostockie Centrum Onkologii ( Site 2604), Bialystok, Podlaskie
Uniwersyteckie Centrum Kliniczne ( Site 2610), Gdansk, Pomorskie
Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 2613), Prabuty, Pomorskie
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie-Oddzial Onkologii z Pododdzialem Chemioterapii ( Site 2606), Olsztyn, Warminsko-mazurskie
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 2602), Poznan, Wielkopolskie
UNIDADE LOCAL DE SAUDE DE MATOSINHOS-Serviço de Oncologia ( Site 2705), Matosinhos, Porto
Instituto Portugês de Oncologia de Coimbra Francisco Gentil-Oncologia Médica ( Site 2704), Coimbra, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2702), Porto, Not set
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L.. ( Site 2803), Bucharest, Bucuresti
Spitalul Universitar de Urgență Elias ( Site 2804), București, Bucuresti
Cardiomed SRL Cluj-Napoca-Medical Oncology ( Site 2801), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2802), Florești, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2805), Craiova, Dolj
SC ONCO CARD SRL ( Site 2808), Brasov, Not set
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2901), L Hospitalet, Barcelona
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2905), Santiago de Compostela, La Coruna
Hospital Insular de Gran Canaria-Oncology ( Site 2903), Las Palmas de Gran Canaria, Las Palmas
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2902), Pozuelo de Alarcon, Madrid
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2900), Barcelona, Not set
Hospital Clinico San Carlos-Oncology Department ( Site 2904), Madrid, Not set
Kantonsspital Graubünden-Medizin ( Site 3006), Chur, Grisons
Kantonsspital Münsterlingen - Spital Thurgau AG ( Site 3005), Munsterlingen, Thurgau
CHUV (centre hospitalier universitaire vaudois) ( Site 3003), Lausanne, Vaud
HFR Fribourg - Hôpital Cantonal ( Site 3004), Fribourg, Not set
National Taiwan University Cancer Center (NTUCC) ( Site 1105), Taipei City, Taipei
Tri-Service General Hospital ( Site 1100), Taipei City, Taipei
Taoyuan General Hospital ( Site 1106), Taoyuan City, Taoyuan
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 1103), Kaohsiung, Not set
Taichung Veterans General Hospital-Chest ( Site 1101), Taichung, Not set
National Cheng Kung University Hospital-Clinical Trial Center ( Site 1102), Tainan, Not set
National Taiwan University Hospital-Oncology ( Site 1104), Taipei, Not set
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 3106), Adana, Not set
Gulhane Egitim Arastirma Hastanesi-Onkoloji ( Site 3104), Ankara, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 3101), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 3110), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 3103), Ankara, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3107), Istanbul, Not set
Conditions: Non Small Cell Lung Cancer
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer
Active Not Recruiting
This phase III trial studies the side effects and how well risk-based therapy works in treating younger patients with newly diagnosed liver cancer. Surgery, chemotherapy drugs (cancer fighting medicines), and when necessary, liver transplant, are the main current treatments for hepatoblastoma. The stage of the cancer is one factor used to decide the best treatment. Treating patients according to the risk group they are in may help get rid of the cancer, keep it from coming back, and decrease the... Read More
This phase III trial studies the side effects and how well risk-based therapy works in treating younger patients with newly diagnosed liver cancer. Surgery, chemotherapy drugs (cancer fighting medicines), and when necessary, liver transplant, are the main current treatments for hepatoblastoma. The stage of the cancer is one factor used to decide the best treatment. Treating patients according to the risk group they are in may help get rid of the cancer, keep it from coming back, and decrease the side effects of chemotherapy. Read Less
Gender:
ALL
Ages:
21 years and below
Trial Updated:
07/25/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +208 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Santa Barbara Cottage Hospital, Santa Barbara, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Lee Memorial Health System, Fort Myers, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Miami Cancer Institute, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
University of Hawaii Cancer Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Tulane University School of Medicine, New Orleans, Louisiana
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
Sinai Hospital of Baltimore, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Kalamazoo Center for Medical Studies, Kalamazoo, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Overlook Hospital, Summit, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
Mercy Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Legacy Emanuel Hospital and Health Center, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Greenville Cancer Treatment Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Brooke Army Medical Center, Fort Sam Houston, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Princess Margaret Hospital for Children, Perth, Western Australia
Instituto De Oncologia Pediatrica, Sao Paulo, Not set
Alberta Children's Hospital, Calgary, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Fukushima Medical University Hospital, Fukushima City, Fukushima Prefecture
Kagoshima University Medical Dental Hospital, Kagoshima City, Kagoshima
Shizuoka Cancer Center, Shizuoka City, Suntou
Nihon University Itabashi Hospital, Itabashi-ku, Tokyo
Hiroshima University Hospital, Hiroshima City, Not set
National Cancer Center Hospital, Tokyo, Not set
San Jorge Children's Hospital, San Juan, Not set
University Pediatric Hospital, San Juan, Not set
Conditions: PRETEXT I Hepatoblastoma, PRETEXT II Hepatoblastoma, PRETEXT III Hepatoblastoma, PRETEXT IV Hepatoblastoma
Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)
Recruiting
The Phase IIIb NIAGARA-2 study aims to expand on the data from the Phase III NIAGARA study by investigating perioperative durvalumab in combination with investigator-selected cisplatin-based neoadjuvant chemotherapy (either ddMVAC or gemcitabine/cisplatin) in a clinical practice setting.
The Phase IIIb NIAGARA-2 study aims to expand on the data from the Phase III NIAGARA study by investigating perioperative durvalumab in combination with investigator-selected cisplatin-based neoadjuvant chemotherapy (either ddMVAC or gemcitabine/cisplatin) in a clinical practice setting. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Research Site, Chermside, Not set +51 locations
Research Site, Chermside, Not set
Research Site, Elizabeth Vale, Not set
Research Site, Heidelberg, Not set
Research Site, Hong Kong, Not set
Research Site, Kogarah, Not set
Research Site, Macquarie University, Not set
Research Site, Murdoch, Not set
Research Site, Port Macquarie, Not set
Research Site, St Leonards, Not set
Research Site, Barretos, Not set
Research Site, Porto Alegre, Not set
Research Site, Santo Andre, Not set
Research Site, Sao Paulo, Not set
Research Site, Hamilton, Ontario
Research Site, London, Ontario
Research Site, Ottawa, Ontario
Research Site, Sherbrooke, Quebec
Research Site, Quebec, Not set
Research Site, Angers Cedex 02, Not set
Research Site, Angers, Not set
Research Site, Bordeaux Cedex, Not set
Research Site, Chambray-lès-Tours, Not set
Research Site, Dijon, Not set
Research Site, Lille, Not set
Research Site, Lyon, Not set
Research Site, Marseille, Not set
Research Site, Montpellier, Not set
Research Site, Nice Cedex 2, Not set
Research Site, Nimes, Not set
Research Site, Paris cedex 15, Not set
Research Site, Pierre Benite, Not set
Research Site, Poitiers, Not set
Research Site, Quint-Fonsegrives, Not set
Research Site, Rennes, Not set
Research Site, Rouen, Not set
Research Site, Strasbourg, Not set
Research Site, Suresnes, Not set
Research Site, Firenze, Not set
Research Site, Orbassano, Not set
Research Site, Roma, Not set
Research Site, Amsterdam, Not set
Research Site, Rotterdam, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Gerona, Not set
Research Site, Las Palmas de Gran Canaria, Not set
Research Site, Lugo, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Santiago de Compostela, Not set
Conditions: Urinary Bladder Neoplasms, Immune Checkpoint Inhibitors, Methotrexate, Vinblastine, Doxorubicin, Cisplatin, Gemcitabine
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