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Cisplatin Treatment Options in Canada
A collection of 326 research studies where Cisplatin is the interventional treatment. These studies are located in the Canada . Cisplatin is used for conditions such as Head and Neck Cancer, Lung Cancer and Non-small Cell Lung Cancer.
85 - 96 of 326
Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma
Recruiting
This study is being done to determine if two new drugs can shrink or eliminate classical Hodgkins lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Concord Repatriation General Hospital, Concord, New South Wales +16 locations
Conditions: Hodgkin Lymphoma
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
Active Not Recruiting
Historically, medulloblastoma treatment has been determined by the amount of leftover disease present after surgery, also known as clinical risk (standard vs. high risk). Recent studies have shown that medulloblastoma is made up of distinct molecular subgroups which respond differently to treatment. This suggests that clinical risk alone is not adequate to identify actual risk of recurrence. In order to address this, we will stratify medulloblastoma treatment in this phase II clinical trial base... Read More
Gender:
ALL
Ages:
Between 3 years and 39 years
Trial Updated:
05/01/2025
Locations: Lucille Packard Children's Hospital at Stanford University Medical Center, Palo Alto, California +22 locations
Conditions: Medulloblastoma
A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer
Active Not Recruiting
This study will test an experimental drug (enfortumab vedotin) alone and with different combinations of anticancer therapies. Pembrolizumab is an immune checkpoint inhibitor (CPI) that is used to treat patients with cancer of the urinary system (urothelial cancer). This type of cancer includes cancer of the bladder, renal pelvis, ureter or urethra. Some parts of the study will look at locally advanced or metastatic urothelial cancer (la/mUC), which means the cancer has spread to nearby tissues o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Alaska Urological Institute, Anchorage, Alaska +105 locations
Conditions: Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Urologic Neoplasms, Renal Pelvis Neoplasms, Urothelial Cancer, Ureteral Neoplasms, Urethral Neoplasms
Efficacy and Safety Study of First-line Treatment With Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Women With Persistent, Recurrent, or Metastatic Cervical Cancer (MK-3475-826/KEYNOTE-826)
Completed
The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) plus one of four platinum-based chemotherapy regimens compared to the efficacy and safety of placebo plus one of four platinum-based chemotherapy regimens in the treatment of adult women with persistent, recurrent, or metastatic cervical cancer. Possible chemotherapy regimens include: paclitaxel plus cisplatin with or without bevacizumab and paclitaxel plus carboplatin with or without bevacizumab.
The prim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Alaska Women's Cancer Care ( Site 1770), Anchorage, Alaska +148 locations
Conditions: Cervical Cancer
TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations
Active Not Recruiting
The purpose of this study is to compare effectiveness of TAK-788 as first-line treatment with that of platinum-based chemotherapy in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors has epidermal growth factor receptor (EGFR) exon 20 insertion mutations.
Participants will be randomly assigned to one of the two treatment groups- TAK-788 group or Platinum-based chemotherapy group.
Participants will receive TAK-788 orally and pemetrexed/cisplatin or... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/21/2025
Locations: City of Hope National Medical Center, Long Beach, California +133 locations
Conditions: Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer
Active Not Recruiting
The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body. Participants who are assigned to the standard treatment and discontinue due to progressive disease have the option to potentially crossover to selpercatinib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2025
Locations: Centro de Oncología e Investigación de Buenos Aires, Berazategui, Buenos Aires +195 locations
Conditions: Non-Small Cell Lung Cancer
A Study of LY3200882 in Participants With Solid Tumors
Active Not Recruiting
The main purpose of this study is to evaluate the safety of the study drug known as LY3200882 in participants with solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2025
Locations: University of Louisville, Louisville, Kentucky +17 locations
Conditions: Solid Tumor
Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)
Completed
This is a study of pembrolizumab plus gemcitabine/cisplatin versus placebo plus gemcitabine/cisplatin as first-line therapy in participants with advanced and/or unresectable biliary tract carcinoma. The primary hypothesis is pembrolizumab plus gemcitabine/cisplatin is superior to placebo plus gemcitabine/cisplatin with respect to overall survival (OS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2025
Locations: University of Alabama at Birmingham Comprehensive Cancer Ctr ( Site 0016), Birmingham, Alabama +184 locations
Conditions: Biliary Tract Carcinoma
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
Recruiting
DESTINY-Lung03 will investigate the safety and tolerability of trastuzumab deruxtecan in combination with Immunotherapy Agents with and without chemotherapy in patients with HER2 over-expressing non-small cell lung cancer. The efficacy will be also analyzed as a secondary endpoint.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2025
Locations: Research Site, Duarte, California +79 locations
Conditions: Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma
Active Not Recruiting
The purpose of this study is to find out what effects new combinations of treatment will have this disease. New promising treatment strategies will be added to this study as they are available to be compared against the standard treatment.
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
04/14/2025
Locations: Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta +12 locations
Conditions: Lymphoma
Study of NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Pancreatic Cancer
Not Yet Recruiting
This study will compare two different regimens for patients with BRCA1/2 or PALB2 mutated metastatic pancreatic cancer after progression on first-line FOLFIRINOX.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Pancreatic Cancer, Advanced or Metastatic, BRCA1/2 Mutation, PALB2 Gene Mutation
A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma
Active Not Recruiting
This study is a randomized, double-blind, multi-center phase III clinical study to compare the efficacy and safety of penpulimab combined with chemotherapy and placebo combined with chemotherapy in the first-line treatment of recurrent or metastatic nasopharyngeal carcinoma.
Gender:
ALL
Ages:
Between 12 years and 75 years
Trial Updated:
04/10/2025
Locations: City of Hope, Duarte, California +55 locations
Conditions: Nasopharyngeal Carcinoma
85 - 96 of 326