A Study of Aflibercept Versus Placebo in Patients With Second-Line Docetaxel for Locally Advanced or Metastatic Non-Small-Cell Lung Cancer
Completed
The primary objective of the study was to demonstrate overall survival improvement for aflibercept + docetaxel compared to docetaxel + placebo as second line treatment for participants with locally advanced or metastatic non-small cell lung cancer (NSCLC). The secondary objectives were to compare other efficacy parameters, to assess the overall safety of the two treatment arms, to assess the pharmacokinetics of intravenous (IV) aflibercept in this participant population and to determine immunog... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2016
Locations: Sanofi-Aventis Administrative Office, Bridgewater, New Jersey +31 locations
Conditions: Carcinoma, Non Small Cell Lung
Low Dose Versus Usual Dose Dexamethasone for Symptom Control in Children Undergoing Cranial or Craniospinal Radiation
Terminated
The purpose of this study is to evaluate the effectiveness of low dose dexamethasone versus high dose dexamethasone in the treatment of radiation induced vomiting.
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
05/03/2016
Locations: Alberta Children's Hospital, Calgary, Alberta +4 locations
Conditions: Vomiting, Headache
The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery
Withdrawn
Many drugs are used to prevent nausea and vomiting and pain after surgery. In this study the investigators will be looking at a drug, dexamethasone, which is commonly used to prevent nausea and vomiting and pain after surgery but has other side effects. Dexamethasone is a man-made drug that is commonly used during surgery but also can affect naturally occuring hormones. In this study the investigators will be looking at dexamethasone's effect on a number of naturally occuring hormones over a twe... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/18/2016
Locations: St Paul's Hospital, Vancouver, British Columbia
Conditions: Adrenal Insufficiency
MTD, Safety, and Efficacy of Pomalidomide (CC-4047) Alone or With Low-dose Dexamethasone in Patients With Relapsed and Refractory Multiple Myeloma
Completed
The purpose of this study is to determine the maximum tolerated dose and effectiveness of the study drug (CC-4047) Alone Or in Combination With Low-dose Dexamethasone as treatment for patients with relapsed and refractory multiple myeloma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2016
Locations: Mayo Clinic Arizona, Scottsdale, Arizona +18 locations
Conditions: Multiple Myeloma
Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating childhood acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing different combination chemotherapy regimens to see how well they work in treating children with acute lymphoblastic leukemia.
Gender:
ALL
Ages:
Between 1 year and 9 years
Trial Updated:
02/19/2016
Locations: Phoenix Children's Hospital, Phoenix, Arizona +129 locations
Conditions: Leukemia
A Pharmacokinetic Study of Trabectedin in Patients With Advanced Malignancies and Hepatic Dysfunction
Completed
The purpose of this study is to characterize the pharmacokinetics (blood levels) of trabectedin after administration to patients with advanced malignancies and hepatic (liver) dysfunction.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/12/2016
Locations: Not set, Scottsdale, Arizona +10 locations
Conditions: Neoplasm Metastases, Hepatic Insufficiency
A Pilot Study of the Effectiveness of Intra-operative Ozurdex® in Vitrectomy Surgery for Epiretinal Membranes
Unknown
To determine if an intravitreal sustained release dexamethasone implant (Ozurdex®) injected at the conclusion of surgery in patients undergoing vitrectomy and membrane peeling for idiopathic epiretinal membranes is safe and effective to decrease the macular edema, as demonstrated by a gain in vision and decreased in retinal thickness and volume.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/04/2016
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario +1 locations
Conditions: Epiretinal Membrane, Macular Edema
The Effect of Intravitreal Ozurdex on DME After Cataract Surgery
Completed
The purpose of this study is to assess the efficacy and safety of OZURDEX (dexamethasone intravitreal implant) 0.7 mg administered immediately after phacoemulsification and intraocular lens implantation in type 1 or 2 diabetic patients to prevent the occurrence of post-surgical macular edema (ME). Treatment group: 24 patients will receive an intravitreal injection of OZURDEX at the end of cataract surgery Patients will be seen at 1 week pre-operatively (baseline visit), and on the same day post... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/30/2015
Locations: UHN, Toronto Western Hospital, Toronto, Ontario
Conditions: Diabetic Macular Edema
A Study of Combination Thalidomide Plus Dexamethasone Therapy vs. Dexamethasone Therapy Alone in Previously Untreated Subjects With Multiple Myeloma
Completed
To compare the efficacy of combination oral thalidomide plus oral dexamethasone treatment to that of oral dexamethasone-alone treatments as induction (first-line) therapy for subjects with active multiple myeloma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2015
Locations: Clinical Research Consultants, Inc., Hoover, Alabama +98 locations
Conditions: Multiple Myeloma
Dexamethasone Tolerability in the Treatment of Acute Asthma in Children
Completed
The purpose of this study is to assess whether smaller volumes of oral dexamethasone result in better tolerability, specifically less vomiting, in pediatric patients during an acute asthma exacerbation.
Gender:
ALL
Ages:
Between 2 years and 14 years
Trial Updated:
08/25/2015
Locations: IWK Health Centre, Halifax, Nova Scotia
Conditions: Asthma
Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma
Completed
This phase I trial studies the side effects and the best dose of temsirolimus when given together with dexamethasone, mitoxantrone hydrochloride, vincristine sulfate, and pegaspargase in treating young patients with relapsed acute lymphoblastic leukemia or non-Hodgkin lymphoma. Temsirolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as dexamethasone, mitoxantrone hydrochloride, vincristine sulfate, and pegaspargase... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
07/09/2015
Locations: Children's Hospital of Alabama, Birmingham, Alabama +30 locations
Conditions: Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia, Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Recurrent Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Lymphoblastic Lymphoma
Study Trial of Dexamethasone Use for Alleviation of Symptoms After Scleral Buckle Eye Surgery
Withdrawn
Dexamethasone is a medication that has been shown to have clear anti-nausea, anti-inflammatory, and painkilling properties. Dexamethasone is currently used to manage postoperative symptoms of a variety of surgical procedures. However, its effect has not been validated for scleral buckling surgery, which is used to treat retinal detachment, a medical emergency that can lead to permanent blindness. In this study, the investigators will randomly administer dexamethasone to half of scleral buckling... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
06/02/2015
Locations: St. Michael's Hospital, Toronto, Ontario +1 locations
Conditions: Retinal Detachment