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Dexamethasone Treatment Options in Canada
A collection of 294 research studies where Dexamethasone is the interventional treatment. These studies are located in the Canada . Dexamethasone is used for conditions such as Multiple Myeloma, Postoperative Pain and Lymphoma.
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A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
Active Not Recruiting
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexa... Read More
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Leucovorin decreases the toxic effects of methotrexate. Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. Read Less
Gender:
ALL
Ages:
Between 365 days and 31 years
Trial Updated:
08/20/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +227 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Santa Barbara Cottage Hospital, Santa Barbara, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Palms West Radiation Therapy, Loxahatchee Groves, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Miami Cancer Institute, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Atrium Health Navicent, Macon, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Northwestern Medicine Central DuPage Hospital, Winfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Jersey Shore Medical Center, Neptune, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Presbyterian Hospital, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Maimonides Medical Center, Brooklyn, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Vannie Cook Children's Clinic, McAllen, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Edwards Comprehensive Cancer Center, Huntington, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Monash Medical Center-Clayton Campus, Clayton, Victoria
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
HIMA San Pablo Oncologic Hospital, Caguas, Not set
University Pediatric Hospital, San Juan, Not set
Conditions: B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Down Syndrome
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations
Active Not Recruiting
This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. Chemotherapy drugs, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than o... Read More
This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. Chemotherapy drugs, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) and giving the drugs in different doses and in different combinations may kill more cancer cells. Read Less
Gender:
ALL
Ages:
Between 1 year and 31 years
Trial Updated:
08/20/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +238 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Santa Barbara Cottage Hospital, Santa Barbara, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Lee Memorial Health System, Fort Myers, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Palms West Radiation Therapy, Loxahatchee Groves, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Miami Cancer Institute, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
University of Hawaii Cancer Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Tulane University School of Medicine, New Orleans, Louisiana
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Overlook Hospital, Summit, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
Mercy Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Greenville Cancer Treatment Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Vannie Cook Children's Clinic, McAllen, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
Royal Brisbane and Women's Hospital, Herston, Queensland
Royal Children's Hospital-Brisbane, Herston, Queensland
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Monash Medical Center-Clayton Campus, Clayton, Victoria
Royal Children's Hospital, Parkville, Victoria
Princess Margaret Hospital for Children, Perth, Western Australia
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Our Lady's Children's Hospital, Dublin, Co Dublin
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
San Jorge Children's Hospital, San Juan, Not set
University Pediatric Hospital, San Juan, Not set
Swiss Pediatric Oncology Group - Geneva, Geneva, Not set
Swiss Pediatric Oncology Group - Lausanne, Lausanne, Not set
Conditions: B Acute Lymphoblastic Leukemia, Central Nervous System Leukemia, Testicular Leukemia, B Acute Lymphoblastic Leukemia, BCR-ABL1-Like
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma
Recruiting
The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in various combinations in patients with relapsed/refractory (R/R) multiple myeloma (MM) and chromosomal translocation t(11;14).
The study investigates sonrotoclax alone and in combination with dexamethasone and other agents, including carfilzomib, daratumumab, and pomalidomide.
The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in various combinations in patients with relapsed/refractory (R/R) multiple myeloma (MM) and chromosomal translocation t(11;14).
The study investigates sonrotoclax alone and in combination with dexamethasone and other agents, including carfilzomib, daratumumab, and pomalidomide. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: University of Alabama At Birmingham Hospital, Birmingham, Alabama +93 locations
University of Alabama At Birmingham Hospital, Birmingham, Alabama
City of Hope National Medical Center, Duarte, California
City of Hope At Irvine Lennar, Irvine, California
University of California At San Francisco, San Francisco, California
University of Miami, Miami, Florida
Emory University Winship Cancer Center, Atlanta, Georgia
University of Chicago Medical Center, Chicago, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Massachusetts General Hospital, Boston, Massachusetts
Washington University School of Medicine, Saint Louis, Missouri
Hackensack University Medical Center, Hackensack, New Jersey
Weill Cornell Medical College Newyork Presbyterian Hospital, New York, New York
Memorial Sloan Kettering Cancer Center Mskcc, New York, New York
The James Cancer Hospital and Solove Research Institute At Ohio State University, Columbus, Ohio
Huntsman Cancer Institute, Salt Lake City, Utah
University of Washington, Seattle, Washington
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Canberra Hospital, Garran, Australian Capital Territory
Nepean Hospital, Kingswood, New South Wales
Monash Health, Clayton, Victoria
St Vincents Hospital Melbourne, Fitzroy, Victoria
The Alfred Hospital, Melbourne, Victoria
Royal Perth Hospital, Perth, Western Australia
Hospital Sirio Libanes Brasilia, Brasilia, Not set
Instituto Dor de Pesquisa E Ensino Distrito Federal, Brasilia, Not set
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre, Not set
Hospital Sao Rafael (Rede Dor), Salvador, Not set
Hospital Sirio Libanes, Sao Paulo, Not set
Hospital Nove de Julho Dasa, Sao Paulo, Not set
Accamargo Cancer Center, Sao Paulo, Not set
Instituto Dor de Pesquisa E Ensino Sao Paulo, Sao Paulo, Not set
Clinica Sao Germano, Sao Paulo, Not set
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, Sao Paulo, Not set
Cross Cancer Institute, Edmonton, Alberta
British Columbia Cancer Agency the Vancouver Centre, Vancouver, British Columbia
Princess Margaret Cancer Centre, Toronto, Ontario
Peking University Third Hospital, Beijing, Beijing
Beijing Chao Yang Hospital, Beijing, Beijing
Peking University Peoples Hospital, Beijing, Beijing
Chongqing Cancer Hospital, Chongqing, Chongqing
Fujian Medical University Union Hospital, Fuzhou, Fujian
The First Affiliated Hospital of Xiamen University, Xiamen, Fujian
Sun Yat Sen University Cancer Center, Guangzhou, Guangdong
Guangdong Provincial Peoples Hospital, Guangzhou, Guangdong
The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei
Henan Cancer Hospital, Zhengzhou, Henan
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei
Hunan Cancer Hospital, Changsha, Hunan
Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu
Jiangsu Province Hospital, Nanjing, Jiangsu
The First Affiliated Hospital of Nanchang University Branch Xianghu, Nanchang, Jiangxi
The First Hospital of China Medical University, Shenyang, Liaoning
Qingdao Municipal Hospital, Qingdao, Shandong
Affiliated Zhongshan Hospital of Fudan University, Shanghai, Shanghai
Shanghai Fourth Peoples Hospital Affiliated to Tongji University, Shanghai, Shanghai
Tianjin Medical University General Hospital, Tianjin, Tianjin
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch, Tianjin, Tianjin
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang
Hopital Claude Huriez Chu Lille, Lille, Not set
Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes, Not set
Chu de Poitiers Site de La Mileterie, Poitiers, Not set
Universitaetsklinikum Aachen, Aachen, Not set
Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden, Dresden, Not set
Universitatsklinikum Hamburg Eppendorf, Hamburg, Not set
Universitatsklinikum Wurzburg, Wurzburg, Not set
University Hospital of Alexandroupolis, Alexandroupolis, Not set
General Hospital of Athens Alexandra, Athens, Not set
Rabin Medical Center, Petach Tikva, Not set
Sourasky Medical Center, Tel Aviv Jaffa, Not set
Azienda Ospedaliera Policlinico Di Bari, Bari, Not set
Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna, Not set
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst, Meldola, Not set
Istituto Europeo Di Oncologia, Milano, Not set
Fondazione Policlinico Universitario Agostino Gemelli, Roma, Not set
Istituto Di Candiolo Irccs, Torino, Not set
Azienda Ospedaliera Universitaria Delle Marche, Torrette, Not set
Samsung Medical Center, GangnamGu, Seoul Teugbyeolsi
The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi
Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Asan Medical Center, SongpaGu, Seoul Teugbyeolsi
Aotearoa Clinical Trials, Auckland, Not set
National University Hospital Singapore, Singapore, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital San Pedro de Alcantara, Caceres, Not set
Hospital Universitario Virgen de La Victoria, Malaga, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set
University College Hospital, London, Not set
Royal Marsden Nhs Foundation Royal Marsden Hospital, Sutton, Not set
Royal Cornwall Hospitalsnhs Trust, Truro, Not set
Conditions: Relapsed/Refractory Multiple Myeloma
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
Recruiting
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma.
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Local Institution - 0071, Birmingham, Alabama +123 locations
Local Institution - 0071, Birmingham, Alabama
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California
Local Institution - 0130, Miami, Florida
Winship Cancer Institute, Emory University, Atlanta, Georgia
Local Institution - 0218, Shreveport, Louisiana
Local Institution - 0196, Boston, Massachusetts
Local Institution - 0067, Charlotte, North Carolina
Local Institution - 0216, Winston-Salem, North Carolina
Local Institution - 0193, Cleveland, Ohio
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Local Institution - 0044, Salt Lake City, Utah
Local Institution - 0195, Milwaukee, Wisconsin
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0214, ABB, Ciudad Autónoma De Buenos Aires
Hospital Aleman, Buenos Aires, Ciudad Autónoma De Buenos Aires
Royal Prince Alfred Hospital, Camperdown, New South Wales
Local Institution - 0190, Liverpool, New South Wales
Local Institution - 0140, Brisbane, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Monash Health, Clayton, Victoria
Peter MacCallum Cancer Centre, Melbourne, Victoria
Local Institution - 0191, Melbourne, Victoria
Fiona Stanley Hospital, Murdoch, Western Australia
Ordensklinikum Linz GmbH Elisabethinen, Linz, Oberösterreich
Hanusch-Krankenhaus, Vienna, Not set
Local Institution - 0220, Edegem, Antwerpen
Local Institution - 0217, Brussels, Bruxelles-Capitale, Région De
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir, Namur
UZ Gent, Gent, Oost-Vlaanderen
Local Institution - 0012, Nova Lima, Minas Gerais
Local Institution - 0103, São Paulo, SAO Paulo
Local Institution - 0013, Sao Paulo, São Paulo
Local Institution - 0031, São Paulo, Not set
Local Institution - 0069, Calgary, Alberta
Vancouver General Hospital, Vancouver, British Columbia
QEII Health Sciences Centre - Victoria General Site, Halifax, Nova Scotia
Local Institution - 0192, Hamilton, Ontario
CIUSSS de l'Est-de-l'Île-de-Montréal, Montreal, Quebec
Fakultní nemocnice Brno Bohunice, Brno, Brno-město
Local Institution - 0093, Hradec Kralove, Hradec Králové
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Rigshospitalet, Copenhagen, Hovedstaden
Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland
Local Institution - 0208, Roskilde, Sjælland
Odense Universitetshospital, Odense, Syddanmark
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki, Uusimaa
Hopital Claude Huriez - CHU de Lille, Lille, Nord
Local Institution - 0194, Nantes, Pays-de-la-Loire
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Henri Mondor Hospital, Creteil, Val-de-Marne
Local Institution - 0210, Paris, Not set
TUM Universitätsklinikum, Technische Universität München, Munich, Bayern
Medizinische Hochschule Hannover, Hannover, Niedersachsen
Local Institution - 0211, Magdeburg, Sachsen-Anhalt
Local Institution - 0204, Chemnitz, Sachsen
Universitätsklinikum Leipzig, Leipzig, Sachsen
Local Institution - 0212, Kiel, Schleswig-Holstein
Local Institution - 0213, Berlin, Not set
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Klinikum Nuernberg Nord, Nuremberg, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
University Hospital of Patras, Patras, Achaḯa
Evangelismos General Hospital of Athens, Athens, Attikí
Local Institution - 0115, Chaidari, Attikí
Local Institution - 0125, Budapest, Not set
Sheba Medical Center, Ramat Gan, HaMerkaz
Sourasky Medical Center, Tel Aviv, Tell Abīb
Hadassah Medical Center, Jerusalem, Yerushalayim
Local Institution - 0107, Milan, Lombardia
Istituto Clinico Humanitas, Rozzano, Milano
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Piemonte
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Local Institution - 0119, Genova, Not set
Local Institution - 0106, Udine, Not set
Nagoya City University Hospital, Nagoya, Aichi
Local Institution - 0105, Kashiwa, Chiba
Hyogo Medical University Hospital, Nishinomiya, Hyogo
Kanazawa University Hospital, Kanazawa, Ishikawa
Kyushu University Hospital, Fukuoka, Not set
Kumamoto University Hospital, Kumamoto, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Red Cross Hospital, Osaka, Not set
Japanese Red Cross Medical Center, Tokyo, Not set
Yamagata University Hospital, Yamagata, Not set
Local Institution - 0147, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0146, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0148, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0149, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0176, Nijmegen, Gelderland
Maastricht UMC+, Maastricht, Limburg
Local Institution - 0179, Amsterdam, Noord-Holland
Universitair Medisch Centrum Utrecht, Utrecht, Not set
Oslo Universitetssykehus Ullevål, Oslo, Not set
Centrum Onkologii Ziemi Lubelskiej, Lublin, Lubelskie
Uniwersyteckie Centrum Kliniczne, Gdańsk, Pomorskie
Local Institution - 0084, Katowice, Not set
Local Institution - 0183, Łódź, Łódzkie
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Fundeni Clinical Institute, Bucuresti, București
Institutul Regional de Oncologie, Iași, Not set
Local Institution - 0178, Riyadh, Not set
Local Institution - 0180, Singapore, Central Singapore
Local Institution - 0181, Singapore, Central Singapore
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña]
Local Institution - 0203, Palma, Balears [Baleares]
Local Institution - 0201, Badalona, Barcelona [Barcelona]
Clinica Universidad de Navarra, Pamplona, Navarra
Local Institution - 0202, Granada, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Local Institution - 0023, Lund, Skåne Län [se-12]
Karolinska Universitetssjukhuset Huddinge, Huddinge, Not set
Inselspital Bern, Bern, Berne
Cantonal Hospital St.Gallen, st.Gallen, Sankt Gallen
Local Institution - 0150, Taipei City, Taipei
Local Institution - 0151, Taichung, Not set
Local Institution - 0152, Taipei, Not set
Local Institution - 0200, Taipei, Not set
Local Institution - 0170, Ankara, Not set
Addenbrooke's Hospital, Cambridge, Cambridgeshire
Local Institution - 0155, London, London, City Of
Local Institution - 0157, Oxford, Oxfordshire
The Christie NHS Foundation Trust, Manchester, Not set
Freeman Hospital, Newcastle upon Tyne, Not set
Conditions: Relapsed or Refractory Multiple Myeloma (RRMM)
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
Recruiting
The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd).
The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: UCSF Fresno, Clovis, California +228 locations
UCSF Fresno, Clovis, California
City of Hope Cancer Center, Duarte, California
City of Hope Orange County Lennar Foundation Cancer Center, Irvine, California
University of Connecticut, Farmington, Connecticut
Yale New Haven Hospital, New Haven, Connecticut
ChristianaCare Helen F Graham Cancer Center and Research Institute, Newark, Delaware
Cleveland Clinic Florida, Weston, Florida
University Of Illinois Medical Center, Chicago, Illinois
University of Iowa Health Care, Waukee, Iowa
Norton Cancer Institute, Louisville, Kentucky
LSUHSC Shreveport Feist-Weiller Cancer Center, Shreveport, Louisiana
Johns Hopkins University School of Medicine JHUSOM, Baltimore, Maryland
Cancer And Hematology Centers of Western Michigan PC, Grand Rapids, Michigan
Nebraska Cancer Specialists, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Astera Cancer Care, East Brunswick, New Jersey
Christus St. Vincent Regional Cancer Center, Santa Fe, New Mexico
Hematology-Oncology Associates of CNY, East Syracuse, New York
Northwell Health Cancer Institute, Lake Success, New York
NYU Langone Hospital Long Island, Mineola, New York
Perlmutter Cancer Center at NYU Langone Health, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Durham VAMC, Durham, North Carolina
University of Cincinnati, Cincinnati, Ohio
University Hospitals Cleveland Medical Center, Cleveland, Ohio
OhioHealth, Columbus, Ohio
Allegheny Health Network, Pittsburgh, Pennsylvania
Joe Arrington Cancer Research Treatment Center, Lubbock, Texas
Utah Cancer Specialists, Salt Lake City, Utah
NorthWest Medical Specialties, PLLC, Tacoma, Washington
Royal Prince Alfred Hospital, Camperdown, Not set
Barwon Health - University Hospital Geelong, Geelong, Not set
Liverpool Hospital, Liverpool, Not set
Sir Charles Gairdner Hospital, Nedlands, Not set
Calvary Mater Newcastle Hospital, New South Wales, Not set
Wollongong Hospital, Wollongong, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
SCRI CCCIT gem GmbH, Salzburg, Not set
Medical University Vienna, Vienna, Not set
Hanusch Krankenhaus, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
ZAS Cadix, Antwerpen, Not set
Ghent University Hospital, Gent, Not set
Jolimont, Haine Saint Paul La Louviere, Not set
Az Groeninge, Kortrijk, Not set
Universitair Ziekenhuis Leuven, Leuven, Not set
GZA Ziekenhuizen- Campus St Augustinus, Wilrijk, Not set
Fundacao Pio XII, Barretos, Not set
Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte, Not set
Liga Paranaense de Combate ao Cancer, Curitiba, Not set
Instituto Do Cancer Do Ceara, Fortaleza, Not set
Liga Norte Riograndense Contra O Cancer, Natal, Not set
Complexo Hospitalar de Niteroi, Niteroi, Not set
Hospital De Clinicas De Porto Alegre, Porto Alegre, Not set
Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP, Ribeirao Preto, Not set
Hospital Sao Rafael, Salvador, Not set
Hospital Nove de Julho, Sao Paulo, Not set
Clinica Medica Sao Germano S/S LTDA, Sao Paulo, Not set
Hospital Das Clinicas Da Faculdade De Medicina Da USP, Sao Paulo, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
British Columbia Cancer Agency, Vancouver, British Columbia
CHU de Quebec L Hotel Dieu de Quebec, Quebec, Not set
Peking Union Medical College Hospital, Beijing, Not set
Peking University First Hospital, Beijing, Not set
Beijing Tongren Hospital CMU, Beijing, Not set
Changzhou No 2 Peoples Hospital, Chang Zhou, Not set
The First Hospital of Jilin University, Changchun, Not set
The Second Xiangya Hospital of Central South Hospital, Changsha, Not set
Beijing Chaoyang Hospital, Chaoyang District, Not set
Sichuan Provincial Peoples Hospital, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Fujian Meidical University Union Hospital, Fu Zhou, Not set
Nanfang Hospital, Guangzhou, Not set
Sun Yat -Sen University Cancer Center, Guangzhou, Not set
The Second Affiliated Hospital of Zhejiang University, Hang Zhou, Not set
No.1 Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Not set
Harbin medical university cancer hospital, Harbin, Not set
Qilu Hospital of Shandong University, Jinan, Not set
Zhongda Hospital Southeast University, Nan Jing, Not set
The First Affiliated Hospital of Guangxi Medical University, Nan Ning Shi, Not set
The First Affliated Hospital Of Nanchang University, Nanchang, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Ruijin Hospital Shanghai Jiao Tong University, Shanghai, Not set
Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Not set
Shanghai Fourth People s Hospital, Shanghai, Not set
Peking University Shenzhen Hospital, Shen Zhen Shi, Not set
Shengjing Hospital Of China Medical University, Shenyang, Not set
Institute of Hematology and Blood Diseases Hospital, Tian Jin, Not set
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Not set
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set
Wuhan Tongji Hospital Tongji Medical College, WuHan, Not set
The Second Affiliated Hospital of Xi'an Jiaotong University, Xi' An, Not set
The first affiliated hospital of xiamen university, Xiamen, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Fakultni nemocnice Brno, Brno - Bohunice, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni nemocnice Olomouc, Olomouc, Not set
Fakultni Nemocnice Ostrava, Ostrava, Not set
Fakultni nemocnice Plzen, Plzen, Not set
VFN v Praze, Praha, Not set
Aalborg University Hospital, Aalborg, Not set
Regionshospitalet Godstrup, Herning, Not set
Zealand University Hospital, Roskilde, Not set
Vejle Sygehus, Vejle, Not set
APHP - Hopital Henri Mondor, Creteil, Not set
Hopital Claude Huriez, Lille, Not set
CHU Nantes, Nantes, Not set
CHU Hopital Saint Antoine, PARIS cedex 12, Not set
CHU de Bordeaux - Hospital Haut-Leveque, Pessac cedex, Not set
CHU Lyon Sud, Pierre-Benite, Not set
CHU Poitiers - Hopital la Miletrie, Poitiers, Not set
CHU de Rennes - Hopital Pontchaillou, Rennes, Not set
Institut de Cancerologie Strasbourg Europe ICANS, Strasbourg, Not set
Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, Not set
Helios Kliniken Berlin Buch Gmbh, Berlin, Not set
Med. Universitatsklinik Essen, Essen, Not set
Universitaetsklinikum Halle Saale, Halle (Saale), Not set
Universitaetsklinik Hamburg-Eppendorf, Hamburg, Not set
Klinikum Nuernberg Nord, Nuernberg, Not set
Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,, Tübingen, Not set
Universitaetsklinikum Wuerzburg, Wurzburg, Not set
Alexandra General Hospital of Athens, Athens Attica, Not set
G Papanikolaou Hospital of Thessaloniki, Thessalonikis, Not set
Anticancer Hospital of Thessaloniki Theageneio, Thessaloniki, Not set
Rambam Medical Center, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Rabin, Petah Tikva, Not set
Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv Yafo, Not set
ASST Papa Giovanni XXIII Bergamo, Bergamo, Not set
A O U Sant Orsola Malpighi, Bologna, Not set
Careggi University Hospital, Firenze, Not set
Ospedale San Raffaele, Milan, Not set
Azienda Ospedaliera di Rilievo Nazionale A Cardarelli, Naples, Not set
IRCCS Policlinico San Matteo, Università degli studi di Pavi, Pavia, Not set
Universita Degli Studi di Roma Tor Vergata, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino, Torino, Not set
Juntendo University Hospital, Bunkyo Ku, Not set
Chiba Cancer Center, Chiba, Not set
Kameda Medical Center, Chiba, Not set
National Hospital Organization Mito Medical Center, Higashiibaraki-gun, Not set
Kansai Medical University Hospital, Hirakata, Not set
Hyogo Medical University Hospital, Hyôgo, Not set
Saitama Medical University Hospital, Iruma-gun, Not set
Tokai University Hospital, Kanagawa, Not set
Kanazawa University Hospital, Kanazawa, Not set
Kumamoto University Hospital, Kumamoto-shi, Not set
Matsuyama Red Cross Hospital, Matsuyama-City, Not set
National Hospital Organization Nagasaki Medical Center, Nagasaki, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
National Hospital Organization Hokkaido Cancer Center, Sapporo, Not set
National Hospital Organization Shibukawa Medical Center, Shibukawa, Not set
Japanese Red Cross Medical Center, Shibuya-ku, Not set
Shizuoka Cancer Center, Sunto Gun, Not set
Fujita Health University Hospital, Toyoake, Not set
Yamagata University Hospital, Yamagata, Not set
Yamanashi Prefectural Central Hospital, Yamanashi, Not set
Dong-A University Hospital, Busan, Not set
Pusan National University Hospital, Busan, Not set
Kyungpook National University Hospital, Daegu, Not set
National Cancer Center, Goyang si, Not set
Chonnam National University Hwasun Hospital, Hwasun, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Mary s Hospital, Seoul, Not set
VUMC Amsterdam, Amsterdam, Not set
Gelre Ziekenhuis, Apeldoorn, Not set
Reinier de Graaf Gasthuis, Delft, Not set
St. Antonius Ziekenhuis Nieuwegein, Nieuwegein, Not set
Zuyderland Medical Center, Sittard-Geleen, Not set
Oslo University Hospital HF Ulleval sykehus, Oslo, Not set
St. Olavs Hospital, Trondheim, Not set
Wojewodzki Szpital Kliniczny w Bialej Podlaskiej, Biala Podlaska, Not set
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozow, Not set
Szpital Uniwersytecki nr 2 im. Jana Biziela w Bydgoszczy, Bydgoszcz, Not set
Pratia Onkologia Katowice, Katowice, Not set
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce, Not set
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi, Lodz, Not set
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli, Lublin, Not set
Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan, Not set
Szpital Uniwersytecki im Karola Marcinkowskiego w Zielonej Gorze, Zielona Gora, Not set
Uls Braga - Hosp. Braga, Braga, Not set
Champalimaud Foundation Champalimaud Centre, Lisbon, Not set
Instituto Portugues de Oncologia, Porto, Not set
Uls Hosp Sao Joao, Porto, Not set
Hosp. Univ. Germans Trias I Pujol, Badalona, Not set
Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp. Univ. Virgen de Las Nieves, Granada, Not set
Hosp. de Jerez de La Frontera, Jerez de la Frontera, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Hosp. Univ. La Paz, Madrid, Not set
Hosp Univ Hm Sanchinarro, Madrid, Not set
Hosp. Univ. Son Espases, Palma de Mallorca, Not set
Hosp. Quiron Madrid Pozuelo, Pozuelo de Alarcon, Not set
Hosp Clinico Univ de Salamanca, Salamanca, Not set
Hosp. Mutua Terrassa, Terrassa, Not set
Hosp. Clinico Univ. de Valencia, Valencia, Not set
Falu Lasarett, Falun, Not set
Skanes universitetssjukhus, Lund, Not set
Karolinska University Hospital Huddinge, Stockholm, Not set
Universitetssjukhuset Orebro, Örebro, Not set
Inselspital Universitatsspital Bern, Bern, Not set
Kantonsspital St Gallen, St. Gallen, Not set
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Not set
Ankara University Medical Faculty, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Memorial Antalya Hospital, Antalya, Not set
Pamukkale University Medical Faculty, Denizli, Not set
Medipol University Hospital, Istanbul, Not set
Dokuz Eylul University Medical Faculty, Izmir, Not set
Ondokuz Mayis University, Samsun, Not set
University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set
Blackpool Victoria Hospital, Blackpool, Not set
University Hospitals Bristol and Weston, Bristol, Not set
Addenbrooke's Hospital, Cambridge, Not set
Kent and Canterbury Hospital, Canterbury, Not set
Western General Hospital, Edinburgh, Not set
University College London Hospitals, London, Not set
Imperial College Healthcare, London, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Multiple Myeloma
A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma
Recruiting
The purpose of this study is to compare the efficacy of teclistamab with PVd/Kd in Part 1 and to further characterize safety and efficacy of an alternative dosing for teclistamab in Part 2 in participants with relapsed or refractory multiple myeloma.
The purpose of this study is to compare the efficacy of teclistamab with PVd/Kd in Part 1 and to further characterize safety and efficacy of an alternative dosing for teclistamab in Part 2 in participants with relapsed or refractory multiple myeloma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2025
Locations: Alaska Oncology and Hematology LLC, Anchorage, Alaska +209 locations
Alaska Oncology and Hematology LLC, Anchorage, Alaska
Banner MD Anderson Cancer Center, Gilbert, Arizona
Alta Bates Comprehensive Cancer Center, Berkeley, California
MemorialCare Long Beach Medical Center, Long Beach, California
University of California Irvine, Orange, California
PIH Health Hospital, Whittier, California
Rocky Mountain Cancer Centers, Aurora, Colorado
University of Connecticut, Farmington, Connecticut
University of Miami Sylvester Cancer Center, Miami, Florida
Orlando Health Cancer Institute, Orlando, Florida
Cleveland Clinic Florida, Weston, Florida
Mission Cancer Blood, Waukee, Iowa
East Jefferson General Hospital Bone Marrow Transport Clinic, Metairie, Louisiana
Walter Reed National Military Medical Center, Bethesda, Maryland
Maryland Oncology Hematology P A, Silver Spring, Maryland
Boston University Medical Center, Boston, Massachusetts
Saint Lukes Hospital Saint Lukes Cancer Specialists, Chesterfield, Missouri
Cooper Health System MD Anderson Cancer Center at Cooper, Camden, New Jersey
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York, New York
Durham VAMC, Durham, North Carolina
Penn Medicine Lancaster General Health, Lancaster, Pennsylvania
Tennessee Oncology, Nashville, Tennessee
Brooke Army Medical Center, Fort Sam Houston, Texas
Baylor College of Medicine, Houston, Texas
Michael E DeBakey VA Medical Center, Houston, Texas
Harris Health Smith Clinic, Houston, Texas
Utah Cancer Specialists, Salt Lake City, Utah
Alexander T. Augusta Military Medical Center, Fort Belvoir, Virginia
Virginia Oncology Associates, Norfolk, Virginia
NorthWest Medical Specialties, PLLC, Tacoma, Washington
Blacktown Hospital, Blacktown, Not set
St Vincents Hospital Melbourne, Fitzroy, Not set
Box Hill Hospital, Melbourne, Not set
Fiona Stanley Hospital, Murdoch, Not set
Sir Charles Gairdner Hospital, Nedlands, Not set
LKH - Universitätsklinikum der PMU Salzburg, Salzburg, Not set
Medical University Vienna MUV, Vienna, Not set
Algemeen Ziekenhuis Klina, Brasschaat, Not set
Jolimont, Haine-St-Paul, Not set
Az Groeninge, Kortrijk, Not set
Universitair Ziekenhuis Gasthuisberg, Leuven, Not set
CHR de la Citadelle, Liege, Not set
Hospitais Integradaos da Gavea S/A - DF Star, Brasilia, Not set
Fundacao Universidade de Caxias do Sul, Caxias do Sul, Not set
Liga Paranaense de Combate ao Cancer, Curitiba, Not set
Instituto Joinvilense de Hematologia e Oncologia Ltda Centro de Hematologia e Oncologia, Joinville, Not set
Liga Norte Riograndense Contra O Cancer, Natal, Not set
Complexo Hospitalar de Niteroi, Niteroi, Not set
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro, Not set
Hospital Sao Rafael, Salvador, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base, Sao Jose do Rio Preto, Not set
Sociedade Beneficente de Senhoras Hospital Sirio Libanes, Sao Paulo, Not set
Instituto D Or de Pesquisa e Ensino IDOR, Sao Paulo, Not set
Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, Not set
Clinica Medica Sao Germano LTDA, Sao Paulo, Not set
Real e Benemérita Associação Portuguesa de Beneficência, São Paulo, Not set
Hospital Alemao Oswaldo Cruz, São Paulo, Not set
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Saint John Regional Hospital, Saint John, New Brunswick
Brampton Civic Hospital, Brampton, Ontario
Lakeridge Health Oshawa, Oshawa, Ontario
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont, Montreal, Quebec
Beijing Chaoyang Hospital, Beijing, Not set
BeiJing JiShuiTan Hospital, Beijing, Not set
The First Bethune Hospital of Jilin University, Changchun, Not set
The Third Xiangya Hospital, Central South University, Changsha, Not set
Sichuan Provincial Peoples Hospital, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Fujian Meidical University Union Hospital, Fu Zhou, Not set
Sun Yat -Sen University Cancer Center, Guangzhou, Not set
First affiliated Hospital of Zhejiang University, Hangzhou, Not set
Harbin medical university cancer hospital, Harbin, Not set
The First Affiliated Hospital of NanChang University, Nanchang, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
First Affiliated Hospital of Guangxi Medical University, Nanning, Not set
Shanghai Fourth People s Hospital, Shanghai, Not set
Shengjing Hospital Of China Medical University, Shenyang, Not set
Shenzhen 2nd People's Hospital, Shenzhen, Not set
Institute of Hematology and Blood Diseases Hospital, Tian Jin, Not set
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Not set
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set
Wuhan Union Hospital, Wuhan, Not set
Wuxi People s Hospital, Wuxi, Not set
The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Fakultni nemocnice Brno, Brno, Not set
Fakultni nemocnice Olomouc, Olomouc, Not set
Fakultni Nemocnice Ostrava, Ostrava - Poruba, Not set
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Aalborg University Hospital, Aalborg, Not set
Aarhus University Hospital, Aarhus, Not set
Rigshospitalet, Copenhagen, Not set
Regionshospitalet Godstrup, Herning, Not set
Odense Universitetshospital, Odense C, Not set
Vejle Sygehus, Vejle, Not set
CHU Amiens - Hopital Sud, AMIENS cedex 1, Not set
Hôpital Côte de Nacre, Caen cedex 9, Not set
CHU Grenoble, Grenoble, Not set
Centre Hospitalier du Mans, Le Mans, Not set
Hopital Saint Vincent de Paul, Lille, Not set
CHU de Montpellier Hopital Saint Eloi, Montpellier, Not set
CHU Nantes, Nantes Cedex 1, Not set
Hopital Saint-Antoine, Paris, Not set
Hopital de la Pitie Salpetriere, Paris, Not set
Hopital Necker Enfants Malades, Paris, Not set
Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, Not set
CHU de Nancy - Hopital de Brabois, Vandœuvre-lès-Nancy, Not set
Medizinische Universitat Lausitz Carl Thiem, Cottbus, Not set
Universitatsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Universitätsmedizin Greifswald, Greifswald, Not set
Asklepios Klinik Altona, Hamburg, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Not set
Universitatsklinikum Tubingen, Tübingen, Not set
Universitatsklinikum Ulm, Ulm, Not set
Heinrich-Braun-Klinikum gGmbH, Zwickau, Not set
Alexandra General Hospital of Athens, Athens Attica, Not set
Agios Andreas General Hospital of Patra, Patra, Not set
G Papanikolaou Hospital of Thessaloniki, Thessaloniki, Not set
Fortis Memorial Research Institute, Gurgaon, Not set
Bhagwan Mahaveer Cancer Hospital & Research Centre, Jaipur, Not set
Deenanath Mangeshkar Hospital and Research Centre, Pune, Not set
Hillel Yaffe Medical Center, Hadera, Not set
Bnai Zion Medical Center, Haifa, Not set
Carmel Medical Center, Haifa, Not set
Rabin Medical Center, Petah Tikva, Not set
Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel-Aviv, Not set
A O U Sant Orsola Malpighi, Bologna, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone, Palermo, Not set
Ospedale Santa Chiara AO Universitaria Pisana, Pisa, Not set
Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Not set
Campus Bio Medico di Roma, Roma, Not set
A O Universitaria Senese Ospedale Santa Maria alle Scotte, Siena, Not set
A.O.U. Citta della Salute e della Scienza di Torino - Presidio Molinette, Turin, Not set
ASUI Santa Maria della Misericordia di Udine, Udine, Not set
Ospedale di Circolo e Fondazione Macchi, Varese, Not set
Institute of Science Tokyo Hospital, Bunkyo ku, Not set
Chiba Cancer Center, Chiba, Not set
Ogaki Municipal Hospital, Gifu, Not set
National Hospital Organization Shibukawa Medical Center, Gunma, Not set
Kansai Medical University Hospital, Hirakata, Not set
Hitachi General Hospital, Hitachi, Not set
Saitama Medical University Hospital, Iruma-gun, Not set
Kameda Medical Center, Kamogawa City, Not set
National Cancer Center Hospital East, Kashiwa, Not set
Kurashiki Central Hospital, Kurashiki, Not set
Matsuyama Red Cross Hospital, Matsuyama, Not set
Aichi Medical University Hospital, Nagakute, Not set
JRC Nagasaki Genbaku Hospital, Nagasaki-Shi, Not set
Niigata University Medical And Dental Hospital, Niigata, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Hokkaido University Hospital, Sapporo, Not set
Juntendo University Hospital, Tokyo, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Yamagata University Hospital, Yamagata, Not set
Yamanashi Prefectural Central Hospital, Yamanashi, Not set
Hospital Pulau Pinang, Georgetown, Not set
Hospital Queen Elizabeth, Kota Kinabalu, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Subang Jaya Medical Centre, Subang Jaya, Not set
Meander Medisch Centrum, Amersfoort, Not set
VUMC Amsterdam, Amsterdam, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
UMC Utrecht, Utrecht, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Pratia Onkologia Katowice, Katowice, Not set
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce, Not set
Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie, Lublin, Not set
Uls Almada Seixal - Hosp. Garcia de Orta, Almada, Not set
Uls Braga - Hosp. Braga, Braga, Not set
Champalimaud Foundation Champalimaud Centre, Lisbon, Not set
Instituto Portugues de Oncologia, Porto, Not set
Uls Gaia Espinho, Vila Nova de Gaia, Not set
Hosp. Univ. Germans Trias I Pujol, Badalona, Not set
Institut Catala d Oncologia L Hospitalet, Hospitalet de Llobregat, Not set
Hosp. de Jerez de La Frontera, Jerez de la Frontera, Not set
Hosp. de Leon, Leon, Not set
Hosp. Univ. Infanta Leonor, Madrid, Not set
Hosp. Univ. Ramon Y Cajal, Madrid, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Hosp. Gral. Univ. J.M. Morales Meseguer, Murcia, Not set
Hospital Universitario Central de Asturias, Oviedo, Not set
Hosp. Son Llatzer, Palma de Mallorca, Not set
Hosp. Montecelo, Pontevedra, Not set
Hosp. Quiron Madrid Pozuelo, Pozuelo de Alarcon, Not set
Hospital Universitari i Politecnic La Fe, València, Not set
Falu Lasarett Medicinkliniken Falun, Falun, Not set
Helsingborgs lasarett, Helsingborg, Not set
Akademiska Sjukhuset, Uppsala, Not set
Ankara Gulhane Training and Research Hospital, Ankara, Not set
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Not set
Ankara University Medical Faculty, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Antalya Training And Research Hospital, Antalya, Not set
Ondokuz Mayis University, Atakum, Not set
Pamukkale University Medical Faculty, Denizli, Not set
Medipol University Hospital, Istanbul, Not set
Aberdeen Royal Infirmary, Aberdeen, Not set
University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set
Colchester Hospital University NHS, Colchester, Not set
The Clatterbridge Cancer Centre, Liverpool, Not set
Chelsea And Westminster Hospital, London, Not set
St Georges Hospital, London, Not set
James Cook University Hospital, Middlesborough, Not set
Norfolk and Norwich University Hospital, Norwich, Not set
Royal Stoke University Hospital, Staffordshire, Not set
Conditions: Relapsed or Refractory Multiple Myeloma
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
Recruiting
The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd).
The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2025
Locations: UCSF Fresno, Clovis, California +238 locations
UCSF Fresno, Clovis, California
UCLA, Santa Monica, California
Yale University School Of Medicine, New Haven, Connecticut
Medical Oncology Hematology Consultants, PA, Newark, Delaware
Memorial Healthcare System, Hollywood, Florida
Moffitt Cancer Center, Tampa, Florida
Winship Cancer Institute Emory University, Atlanta, Georgia
City of Hope Cancer Center, Newnan, Georgia
Kootenai Health, Coeur d'Alene, Idaho
University of Iowa Health Care, Waukee, Iowa
Norton Cancer Institute, Louisville, Kentucky
Luminis Health Center for Cancer and Blood Disorders, Annapolis, Maryland
University of Maryland School of Medicine, Baltimore, Maryland
The Sidney Kimmel Comprehensive Cancer Center at John Hopkins, Baltimore, Maryland
University of Michigan, Ann Arbor, Michigan
Henry Ford Cancer Institute, Detroit, Michigan
Henry Ford Health Providence Southfield Hospital, Southfield, Michigan
University Of Minnesota, Minneapolis, Minnesota
Mayo Clinic Rochester, Rochester, Minnesota
Regions Hospital, Saint Paul, Minnesota
University of Nebraska, Omaha, Nebraska
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey
Roswell Park Cancer Institute, Buffalo, New York
Weill Cornell Medical College, New York, New York
SUNY Upstate Medical University, Syracuse, New York
Duke University Medical Center, Durham, North Carolina
Gabrail Cancer Center, Canton, Ohio
Louis Stokes Cleveland VA Med Ctr, Cleveland, Ohio
Cleveland Clinic, Cleveland, Ohio
Oregon Health And Science University, Portland, Oregon
Penn State Milton S Hershey Medical Ctr, Hershey, Pennsylvania
Thomas Jefferson University, Philadelphia, Pennsylvania
West Penn Hospital, Pittsburgh, Pennsylvania
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Bon Secours Saint Francis Cancer Center, Greenville, South Carolina
UT Southwestern, Dallas, Texas
Houston Methodist Neal Cancer Center at Texas Medical Center, Houston, Texas
Huntsman Cancer Institute, Salt Lake City, Utah
University of Virginia, Charlottesville, Virginia
Swedish Cancer Institute, Seattle, Washington
Fred Hutchinson Cancer Research Center, Seattle, Washington
NorthWest Medical Specialties, PLLC, Tacoma, Washington
Gundersen Health System, La Crosse, Wisconsin
Medical College Of Wisconsin, Milwaukee, Wisconsin
Fundaleu, Buenos Aires, Not set
Hospital Aleman, Buenos Aires, Not set
Hospital Britanico de Buenos Aires, Ciudad Autonoma de Buenos Aires, Not set
Royal Adelaide Hospital, Adelaide, Not set
Box Hill Hospital, Box Hill, Not set
St Vincents Hospital, Darlinghurst, Not set
St Vincents Hospital Melbourne, Fitzroy, Not set
Gold Coast University Hospital, Southport, Not set
Perth Blood Institute, West Perth, Not set
Wollongong Hospital, Wollongong, Not set
LKH - Universitätsklinikum der PMU Salzburg, Salzburg, Not set
Klinik Ottakring, Vienna, Not set
Medical University Vienna MUV, Vienna, Not set
Grand Hopital De Charleroi Site Les Viviers, Charleroi, Not set
Ziekenhuis Oost-Limburg, Genk, Not set
Ghent University Hospital, Gent, Not set
AZ Nikolaas - Campus Sint-Niklaas Moerland, Sint-Niklaas, Not set
Cetus Oncologia, Belo Horizonte, Not set
DF Star, Brasilia, Not set
Fundacao Universidade de Caxias do Sul, Caxias do Sul, Not set
Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer, Curitiba, Not set
Hospital De Clinicas De Porto Alegre, Porto Alegre, Not set
Instituto D Or de Pesquisa e Ensino IDOR, Recife, Not set
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro, Not set
Hospital Sao Rafael, Salvador, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base, Sao Jose do Rio Preto, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia, Sao Paulo, Not set
Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, Not set
Clinica Medica Sao Germano S/S LTDA, Sao Paulo, Not set
Instituto D Or de Pesquisa e Ensino, Sao Paulo, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
British Columbia Cancer Agency, Vancouver, British Columbia
Nova Scotia Health Authority, Halifax, Nova Scotia
Juravinski Cancer Centre, Hamilton, Ontario
Princess Margaret Cancer Centre University Health Network, Toronto, Ontario
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont, Montreal, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Beijing Chaoyang Hospital, Beijing, Not set
Peking University First Hospital, Beijing, Not set
Peking University People s Hospital, Beijing, Not set
The Second Xiangya Hospital of Central South Hospital, Changsha, Not set
Changzhou No 2 Peoples Hospital, Changzhou, Not set
Sichuan Provincial Peoples Hospital, Chengdu, Not set
Fujian Meidical University Union Hospital, Fuzhou, Not set
The First Affiliated Hospital of Fujian Medical University, Fuzhou, Not set
Sun Yat Sen University Cancer Center, Guangzhou, Not set
Nanfang Hospital of Southern Medical Hospital, Guangzhou, Not set
First hospital affiliated of Zhejiang Medical university, Hangzhou, Not set
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Not set
The Affiliated Hospital of Inner Mongolia Medical College, Hu He Hao Te Shi, Not set
Qilu Hospital of Shandong University, Jinan, Not set
The First Affiliated Hospital of Guangxi Medical University, Nan Ning Shi, Not set
The First Affiliated Hospital of NanChang University, Nanchang, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Ruijing Hospital Affiliated To Shanghai Jiaotong University School Of Medicine, Shanghai, Not set
Tongji Hospital of Tongji University, Shanghai, Not set
Shanghai Fourth People s Hospital, Shanghai, Not set
Shengjing Hospital Of China Medical University, Shenyang, Not set
Peking University Shenzhen Hospital, Shenzhen, Not set
Shanxi Bethune Hospital, Tai Yuan Shi, Not set
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Not set
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set
Tongji Hospital, Tongji Medical College of HUST, Wuhan, Not set
The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Not set
The first affiliated hospital of xiamen university, Xia Men, Not set
Fakultni nemocnice Brno, Brno - Bohunice, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set
University Hospital Olomouc, Olomouc, Not set
Fakultni Nemocnice Ostrava, Ostrava, Not set
Aarhus University Hospital, Aarhus, Not set
Odense University Hospital, Odense C, Not set
Vejle Hospital, Vejle, Not set
Hopital Claude Huriez, Lille, Not set
CHU de Limoges Hopital Dupuytren, Limoges, Not set
Institut Paoli Calmettes, Marseille, Not set
CHU Nantes, Nantes, Not set
Hopital Saint Louis, Paris, Not set
CHU de Bordeaux - Hospital Haut-Leveque, Pessac Cedex, Not set
CHU Lyon Sud, Pierre Benite, Not set
Institut de Cancerologie Strasbourg Europe ICANS, Strasbourg, Not set
Institut Universitaire du Cancer Toulouse Oncopole, Toulouse Cedex 9, Not set
CHRU Tours Hopital Bretonneau, TOURS Cedex 01, Not set
Klinikum Augsburg, Augsburg, Not set
Universitaetsklinikum Halle Saale, Halle (Saale), Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Universitaetsklinikum Magdeburg A.oe.R, Magdeburg, Not set
Klinikum rechts der Isar der TU Muenchen, München, Not set
Universitaetsklinikum Tuebingen, Tuebingen, Not set
Universitaetsklinikum Wuerzburg, Würzburg, Not set
251 Airforces Hospital, Athens, Not set
Alexandra General Hospital of Athens, Athens, Not set
Anticancer Hospital of Thessaloniki Theageneio, Thessaloniki, Not set
Semmelweis Egyetem, Belgyogyaszati es Hematologiai Klinika, Budapest, Not set
Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely, Budapest, Not set
Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set
Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz, Nyiregyhaza, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set
Fortis Memorial Research Institute, Gurgaon, Not set
Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Not set
Deenanath Mangeshkar Hospital and Research Centre, Pune, Not set
Shamir Medical Center Assaf Harofeh, Be'er Ya'akov, Not set
Carmel Medical Center, Haifa, Not set
Rabin Medical center - Petah-Tikva, Petah-Tikva, Not set
Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Not set
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria, Alessandria, Not set
A O U Sant Orsola Malpighi, Bologna, Not set
oncologia medica - Oncology, Brindisi, Not set
ARNAS Garibaldi P O Nesima, Catania, Not set
Ospedale Policlinico San Martino IRCCS, Genova, Not set
Asst Ovest Milanese - Ospedale Di Legnano, Legnano, Not set
Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano, Milano, Not set
IRCCS Ospedale San Raffaele, Milano, Not set
Fondazione IRCCS Policlinico San Matteo, Pavia, Not set
Presidio Ospedaliero Pescara, Pescara, Not set
Ospedale S. Maria Delle Croci, Ravenna, Not set
Oncologia Medica-Città Della Salute E Della Scienza Di Torino, Torino, Not set
Azienda Ospedaliera Universitaria Integrata Verona, Verona, Not set
Juntendo University Hospital, Bunkyo Ku, Not set
Fukuoka University Hospital, Fukuoka, Not set
Hamamatsu University Hospital, Hamamatsu, Not set
Kanazawa University Hospital, Kanazawa, Not set
University Hospital Kyoto Prefectural University of Medicine, Kyoto, Not set
National Hospital Organization Nagasaki Medical Center, Nagasaki, Not set
Japanese Red Cross Narita Hospital, Narita, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Hyogo Medical University Hospital, Nishinomiya shi, Not set
Japanese Red Cross Osaka Hospital, Osaka, Not set
Sapporo City General Hospital, Sapporo, Not set
Tohoku University Hospital, Sendai, Not set
Japanese Red Cross Medical Center, Shibuya-ku, Not set
Iwate Medical University Hospital, Shiwa-gun, Not set
The University of Osaka Hospital, Suita City, Not set
Shizuoka Cancer Center, Sunto Gun, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Tottori University Hospital, Tottori, Not set
University of Tsukuba Hospital, Tsukuba, Not set
Kanagawa Cancer Center, Yokohama City, Not set
Dong-A University Hospital, Busan, Not set
Pusan National University Hospital, Busan, Not set
Chonnam National University Hwasun Hospital, Jeollanam-do, Not set
Seoul National University Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Mary s Hospital, Seoul, Not set
Ulsan University Hospital, Ulsan, Not set
Centro de Quimioterapia e Investigacion, Guadalajara, Not set
Hematologica Alta Especialidad, Huixquilucan, Not set
Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Not set
Flevoziekenhuis, Almere, Not set
Haga ziekenhuis, Den Haag, Not set
Catharinaziekenhuis, Eindhoven, Not set
St. Antonius Ziekenhuis Nieuwegein, Nieuwegein, Not set
Isala Kliniek, Zwolle, Not set
Wojewodzki Szpital Specjalistyczny, Biala Podlaska, Not set
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozow, Not set
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce, Not set
Centrum Onkologii Ziemii Lubelskiej, Lublin, Not set
Uniwersytecki Szpital Kliniczny Nr 1 PUM im prof Tadeusza Sokolowskiego w Szczecinie, Szczecin, Not set
Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu, Wroclaw, Not set
King Abdullah International Medical Research Center (KAIMRC), Riyadh, Not set
King Faisal Specialist Hospital & Research Center, Riyadh, Not set
King Fahad Medical City, Riyadh, Not set
Hosp. de Cabuenes, Asturias, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp. Univ. de Burgos, Burgos, Not set
Hosp. San Pedro de Alcantara, Cáceres, Not set
Hosp. Univ. Virgen de Las Nieves, Granada, Not set
Hosp. Univ. Lucus Augusti, Lugo, Not set
Hosp. Univ. La Paz, Madrid, Not set
Hosp. Univ. Son Espases, Palma de Mallorca, Not set
Clinica Univ. de Navarra, Pamplona, Not set
Complejo Hosp de Navarra - Hosp de Navarra, Pamplona, Not set
Hosp Clinico Univ de Salamanca, Salamanca, Not set
Hosp. Univ. Donostia, San Sebastian, Not set
Hosp. Univ. Marques de Valdecilla, Santander, Not set
Hosp. Clinico Univ. de Santiago, Santiago de Compostela, Not set
Skanes universitetssjukhus, Lund, Not set
Norrlands Universitetssjukhus, Umea, Not set
Akademiska Sjukhuset, Uppsala, Not set
Varberg Hospital, Varberg, Not set
Ankara University Medical Faculty, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Pamukkale University Medical Faculty, Denizli, Not set
Medipol University Hospital, Istanbul, Not set
Ondokuz Mayis University, Samsun, Not set
Blackpool Victoria Hospital, Blackpool, Not set
University Hospital of Wales, Cardiff, Not set
Ninewells Hospital, Dundee, Not set
St James University Hospital, Leeds, Not set
Kings College Hospital, London, Not set
Nottingham City Hospital, Nottingham, Not set
University Hospitals Plymouth NHS Trust, Plymouth, Not set
Queen Alexandra Hospital, Portsmouth, Not set
Conditions: Relapsed or Refractory Multiple Myeloma
Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma
Recruiting
This study is being done to determine if two new drugs can shrink or eliminate classical Hodgkins lymphoma.
This study is being done to determine if two new drugs can shrink or eliminate classical Hodgkins lymphoma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Concord Repatriation General Hospital, Concord, New South Wales +17 locations
Concord Repatriation General Hospital, Concord, New South Wales
Shoalhaven Cancer Care Centre, Nowra, New South Wales
Wollongong Hospital, Wollongong, New South Wales
Royal Adelaide Hospital, Adelaide, South Australia
Austin Hospital, Heidelberg, Victoria
Sir Charles Gairdner Hospital, Perth, Western Australia
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
BCCA - Vancouver, Vancouver, British Columbia
Dr. H. Bliss Murphy Cancer Centre, St. John's, Newfoundland and Labrador
QEII Health Sciences Centre, Halifax, Nova Scotia
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario
London Health Sciences Centre Research Inc., London, Ontario
Ottawa Hospital Research Institute, Ottawa, Ontario
University Health Network, Toronto, Ontario
The Jewish General Hospital, Montreal, Quebec
The Research Institute of the McGill University, Montreal, Quebec
CIUSSS de l'Estrie - Centre hospitalier, Sherbrooke, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Conditions: Hodgkin Lymphoma
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Recruiting
The purpose of this study is to assess the efficacy and safety of opevesostat plus hormone replacement therapy (HRT) compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) previously treated with one next-generation hormonal agent (NHA). The primary study hypotheses are that opevesostat is superior to alternative abiraterone acetate or enzalutamide with respect to radiographic progression free survival (rPFS) per P... Read More
The purpose of this study is to assess the efficacy and safety of opevesostat plus hormone replacement therapy (HRT) compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) previously treated with one next-generation hormonal agent (NHA). The primary study hypotheses are that opevesostat is superior to alternative abiraterone acetate or enzalutamide with respect to radiographic progression free survival (rPFS) per Prostate Cancer Working Group (PCWG) Modified Response Evaluation Criteria in Solid Tumors (RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and overall survival (OS), in androgen receptor ligand binding domain (AR LBD) mutation positive and negative participants. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: The University of Arizona Cancer Center - North Campus ( Site 0073), Tucson, Arizona +318 locations
The University of Arizona Cancer Center - North Campus ( Site 0073), Tucson, Arizona
UCLA Hematology/Oncology - Santa Monica ( Site 0044), Los Angeles, California
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040), Orange, California
Stanford Cancer Center ( Site 0036), Palo Alto, California
Emad Ibrahim,MD,INC. ( Site 0012), Redlands, California
Kaiser Permanente Riverside Medical Center ( Site 0099), Riverside, California
University of California Davis (UC Davis) Comprehensive Cancer Center ( Site 0114), Sacramento, California
San Francisco VA Health Care System ( Site 0093), San Francisco, California
Kaiser Permanente-Kaiser Permanente, Vallejo Medical Center, Adult Oncology ( Site 0101), Vallejo, California
University of Colorado Anschutz Medical Campus ( Site 0046), Aurora, Colorado
UCHealth Highlands Ranch Hospital ( Site 0111), Highlands Ranch, Colorado
Colorado Clinical Research ( Site 0067), Lakewood, Colorado
University of Colorado Health - Lone Tree Medical Center ( Site 0112), Lone Tree, Colorado
Yale-New Haven Hospital-Yale Cancer Center ( Site 0064), New Haven, Connecticut
MedStar Washington Hospital Center ( Site 0103), Washington, District of Columbia
Florida Cancer Specialists - South ( Site 7003), Fort Myers, Florida
Mount Sinai Cancer Center ( Site 0107), Miami Beach, Florida
Memorial Hospital West-Memorial Cancer Institute ( Site 0109), Pembroke Pines, Florida
Northside Hospital-Northside Hospital Oncology Network ( Site 0100), Atlanta, Georgia
Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0074), Elmhurst, Illinois
Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0075), Naperville, Illinois
Illinois Cancer Care ( Site 0104), Peoria, Illinois
Urology of Indiana - Carmel ( Site 0055), Carmel, Indiana
University of Kentucky Chandler Medical Center ( Site 0048), Lexington, Kentucky
Baltimore Veterans Affairs Medical Center ( Site 0069), Baltimore, Maryland
Greenebaum Comprehensive Cancer Center ( Site 0049), Baltimore, Maryland
Chesapeake Urology ( Site 0009), Towson, Maryland
Henry Ford Hospital ( Site 0015), Detroit, Michigan
Cancer and Hematology Centers of Western Michigan ( Site 0005), Grand Rapids, Michigan
HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0072), Saint Louis Park, Minnesota
HealthPartners Cancer Research Center-HealthPartners Cancer Center at Regions Hospital ( Site 0092), Saint Paul, Minnesota
St. Vincent Frontier Cancer Center-Research ( Site 0037), Billings, Montana
Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 0026), Omaha, Nebraska
OptumCare Cancer Care-Research Department ( Site 0078), Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada ( Site 0010), Las Vegas, Nevada
Rutgers Cancer Institute of New Jersey ( Site 0033), New Brunswick, New Jersey
Associated Medical Professionals - Urology ( Site 0081), Syracuse, New York
University Hospitals Cleveland Medical Center ( Site 0043), Cleveland, Ohio
Central Ohio Urology Group - Gahanna ( Site 0098), Gahanna, Ohio
Genesis Healthcare System ( Site 0102), Zanesville, Ohio
MidLantic urology ( Site 0022), Bala-Cynwyd, Pennsylvania
Fox Chase Cancer Center ( Site 0076), Philadelphia, Pennsylvania
Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083), Charleston, South Carolina
Avera Cancer Institute - Pierre ( Site 0118), Pierre, South Dakota
Avera Cancer Institute- Research ( Site 0094), Sioux Falls, South Dakota
Avera Cancer Institute - Yankton ( Site 0117), Yankton, South Dakota
The West Clinic, PLLC dba West Cancer Center ( Site 0063), Germantown, Tennessee
Texas Oncology - Central/South Texas ( Site 8003), Austin, Texas
Texas Oncology - DFW ( Site 8001), Dallas, Texas
Urology Clinics of North Texas, PLLC ( Site 0077), Dallas, Texas
Texas Oncology - Gulf Coast ( Site 8002), Houston, Texas
University of Virginia Health System ( Site 0054), Charlottesville, Virginia
Inova Schar Cancer Institute ( Site 0017), Fairfax, Virginia
Virginia Cancer Specialists (VCS) ( Site 8004), Fairfax, Virginia
VCU Health Adult Outpatient Pavillion ( Site 0061), Richmond, Virginia
Blue Ridge Cancer Care ( Site 0004), Roanoke, Virginia
Spokane Urology ( Site 0035), Spokane, Washington
Northwest Cancer Specialists (Compass Oncology) ( Site 8008), Vancouver, Washington
MEDICAL COLLEGE OF WISCONSIN ( Site 0020), Milwaukee, Wisconsin
Macquarie University-MQ Health Clinical Trials Unit ( Site 0214), Macquarie University, New South Wales
Westmead Hospital ( Site 0212), Westmead, New South Wales
Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Site 0211), Brisbane, Queensland
Monash Health ( Site 0219), Clayton, Victoria
Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0210), Melbourne, Victoria
Obras Sociais Irma Dulce ( Site 0255), Salvador, Bahia
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0256), Fortaleza, Ceara
Hospital Santa Rita de Cassia ( Site 0271), Vitória, Espirito Santo
Hospital São Domingos ( Site 0258), Sao Luis, Maranhao
Hospital Mario Penna ( Site 0264), Belo Horizonte, Minas Gerais
Universidade Federal do Triangulo Mineiro - Hospital de Clinicas ( Site 0262), Uberaba, Minas Gerais
ICTRIALS Pesquisa e Desenvolvimento ( Site 0274), Curitiba, Parana
Hospital Universitário Evangélico Mackenzie ( Site 0252), Curitiba, Parana
Hospital São Lucas da PUCRS ( Site 0270), Porto Alegre, Rio Grande Do Sul
Clínica de Neoplasias Litoral ( Site 0269), Itajaí, Santa Catarina
Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0251), Bragança Paulista, Sao Paulo
Hospital de Base de São José do Rio Preto ( Site 0275), São José do Rio Preto, Sao Paulo
Instituto do Câncer Brasil - Unidade Taubaté ( Site 0263), Taubaté, Sao Paulo
Hospital Paulistano ( Site 0259), Sao Paulo, Not set
The Ottawa Hospital - General Campus ( Site 0286), Ottawa, Ontario
Sunnybrook Research Institute ( Site 0285), Toronto, Ontario
Centre Hospitalier de l'Université de Montréal ( Site 0276), Montréal, Quebec
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0277), Quebec City, Quebec
CIDO SpA-Oncology ( Site 0302), Temuco, Araucania
Clinica Universidad Catolica del Maule-Oncology ( Site 0306), Talca, Maule
FALP ( Site 0303), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0304), Santiago, Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0301), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0305), Viña del Mar, Valparaiso
The Second Hospital Of Anhui Medical University ( Site 1633), Hefei, Anhui
Peking University First Hospital-Urology ( Site 1602), Beijing, Beijing
Beijing Cancer hospital-Urinary Surgery ( Site 1620), Beijing, Beijing
First Medical Center of Chinese PLA General Hospital ( Site 1601), Beijing, Beijing
Beijing Cancer Hospital ( Site 1623), Beijing, Beijing
Chongqing University Cancer Hospital ( Site 1603), Chongqing, Chongqing
Southwest Hospital of Third Military Medical University ( Site 1645), Chongqing, Chongqing
The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 1639), Fuzhou, Fujian
The first affiliated hospital of Guangzhou medical university ( Site 1637), Guangzhou, Guangdong
Sun Yat-sen University Cancer Center-Urology Surgery ( Site 1638), Guangzhou, Guangdong
Tongji Hospital Tongji Medical,Science & Technology ( Site 1632), Wuhan, Hubei
The Central Hospital of Wuhan ( Site 1635), Wuhan, Hubei
Hubei Cancer Hospital-Urinary surgery ( Site 1631), Wuhan, Hubei
Hunan Cancer Hospital ( Site 1630), Changsha, Hunan
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 1615), NanJing, Jiangsu
Nantong Tumor Hospital-Urology ( Site 1609), Nantong, Jiangsu
Wuxi People's Hospital ( Site 1612), Wuxi, Jiangsu
The First Affiliated Hospital of Xi'an Jiaotong University-Oncology department ( Site 1618), XI An, Shaanxi
The Second Affiliated Hospital of Xi'an Jiaotong University-Oncology Department ( Site 1619), Xi'an, Shaanxi
Yantai Yuhuangding Hospital ( Site 1622), Yantai, Shandong
Renji Hosp Shanghai Jiaotong U School of Med ( Site 1624), Shanghai, Shanghai
Huadong Hospital Affiliated to Fudan University-Urology ( Site 1613), Shanghai, Shanghai
West China Hospital, Sichuan University-Urology Surgery ( Site 1642), Cheng Du, Sichuan
Nanchong Central Hospital-urology ( Site 1647), Nanchong, Sichuan
The Second Hospital of Tianjin Medical University ( Site 1616), Tianjin, Tianjin
Xinjiang Medical University Cancer Hospital - Urumqi-Urology ( Site 1644), Urumqi, Xinjiang
Yunnan Province Cancer Hospital ( Site 1643), Kunming, Yunnan
Zhejiang Provincial People's Hospital-Urology ( Site 1641), Hangzhou, Zhejiang
The First Hospital of Jiaxing-urology ( Site 1605), Jiaxing, Zhejiang
Ningbo First Hospital-Urology ( Site 1608), Ningbo, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University ( Site 1604), Wenzhou, Zhejiang
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0327), Valledupar, Cesar
IMAT S.A.S ( Site 0329), Monteria, Cordoba
Los Cobos Medical Center ( Site 0336), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0326), Bogota, Distrito Capital De Bogota
Fundación Cardiovascular de Colombia ( Site 0328), Piedecuesta, Santander
Fundación Valle del Lili ( Site 0330), Cali, Valle Del Cauca
Clínica Imbanaco S.A.S ( Site 0334), Cali, Valle Del Cauca
CIMCA-Hemato-Oncology ( Site 0380), San José, San Jose
Hospital Metropolitano - Sede Lindora-Metropolitano Research Institute Sede Lindora ( Site 0379), Santa Ana, San Jose
Onco Tech, S.A. ( Site 0376), San Jose, Not set
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0403), Brno, Brno-mesto
Fakultni Nemocnice u sv. Anny v Brne-Onkologicko-chirurgicke oddeleni ( Site 0404), Brno, Jihomoravsky Kraj
Krajská nemocnice Liberec-Department of Urology ( Site 0407), Liberec, Liberecky Kraj
Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0401), Praha, Praha 5
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0405), Olomouc, Not set
Vseobecna fakultni nemocnice v Praze ( Site 0406), Praha 2, Not set
East-Tallinn Central Hospital ( Site 1528), Tallinn, Harjumaa
North Estonia Medical Centre Foundation ( Site 1526), Tallinn, Harjumaa
Tartu University Hospital-Radiotherapy and oncology ( Site 1527), Tartu, Tartumaa
Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0451), Strasbourg, Alsace
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 0461), Bordeaux, Aquitaine
CHU-BREST Cavale Blanche ( Site 0456), Brest, Finistere
Ramsay Santé - Clinical La Croix Du Sud ( Site 0460), Quint-Fonsegrives, Haute-Garonne
Hôpital Foch ( Site 0455), Suresnes, Hauts-de-Seine
Centre Bourgogne ( Site 0464), Lille, Nord-Pas-de-Calais
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0454), Clermont-Ferrand, Puy-de-Dome
CENTRE LEON BERARD ( Site 0459), Lyon Cedex08, Rhone-Alpes
Gustave Roussy ( Site 0452), Villejuif, Val-de-Marne
Sainte Catherine Institut du Cancer Avignon Provence ( Site 0458), Avignon, Vaucluse
Groupe Hospitalier Paris Saint Joseph ( Site 0465), Paris, Not set
Universitaetsklinikum Freiburg-Klinik für Urologie ( Site 0506), Freiburg, Baden-Wurttemberg
Universitaetsklinikum Heidelberg ( Site 0531), Heidelberg, Baden-Wurttemberg
Studienpraxis Urologie ( Site 0529), Nürtingen, Baden-Wurttemberg
klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0521), Munich, Bayern
Caritas-Krankenhaus St. Josef-Klinik fuer Urologie ( Site 0523), Regensburg, Bayern
Universitätsklinikum Marburg-Comprehensive Cancer Center ( Site 0510), Marburg, Hessen
Universitätsmedizin Göttingen - Georg-August-Universität-Klinik für Urologie ( Site 0527), Göttingen, Niedersachsen
Marien-Krankenhaus ( Site 0515), Bergisch Gladbach, Nordrhein-Westfalen
Universitaetsklinikum Koeln ( Site 0518), Köln, Nordrhein-Westfalen
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Urologie ( Site 0528), Dresden, Sachsen
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0504), Berlin, Not set
Vivantes Klinikum Am Urban ( Site 0512), Berlin, Not set
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 0553), Patras, Achaia
Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 0551), Athens, Attiki
ATTIKON GENERAL UNIVERSITY HOSPITAL-2nd Dep. of Int. Medicine. Research Unit & Diabetes Center ( Site 0552), Chaidari, Attiki
Private Practice- Dr. Rixci Augusto Lenin Ramírez ( Site 0577), Ciudad de Guatemala, Not set
MEDI-K ( Site 0576), Guatemala, Not set
CELAN,S.A ( Site 0579), Guatemala, Not set
INTEGRA Cancer Institute-Oncology ( Site 0578), Guatemala, Not set
Sanatorio Nuestra Senora del Pilar ( Site 0580), Guatemala, Not set
Hong Kong Integrated Oncology Centre ( Site 0603), Central, Not set
Queen Mary Hospital ( Site 0602), Hong Kong, Not set
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás C ( Site 0630), Miskolc, Borsod-Abauj-Zemplen
Nograd Varmegyei Szent Lazar Korhaz-Onkologia es Sugarterapias Osztaly ( Site 0636), Salgótarján, Nograd
Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 0631), Budapest, Pest
Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 0632), Debrecen, Not set
St. Vincent's University Hospital ( Site 0652), Dublin 04, Dublin
Tallaght University Hospital ( Site 0651), Dublin, Not set
Emek Medical Center ( Site 0680), Afula, Not set
Rambam Health Care Campus-Oncology Division ( Site 0676), Haifa, Not set
Shaare Zedek Medical Center ( Site 0679), Jerusalem, Not set
Hadassah Medical Center ( Site 0683), Jerusalem, Not set
Meir Medical Center. ( Site 0682), Kfar Saba, Not set
Rabin Medical Center ( Site 0678), Petah Tikva, Not set
Sheba Medical Center ( Site 0677), Ramat Gan, Not set
Sourasky Medical Center ( Site 0681), Tel Aviv, Not set
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 1454), Meldola, Emilia-Romagna
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1452), Milan, Lombardia
Ospedale Cannizzaro ( Site 1455), Catania, Not set
Azienda Ospedaliero Universitaria Policlinico Riuniti di Foggia ( Site 1456), Foggia, Not set
Ospedale San Raffaele-Oncologia Medica ( Site 1451), Milano, Not set
Azienda Ospedaliera Santa Maria Terni ( Site 1458), Terni, Not set
Toho University Sakura Medical Center ( Site 0730), Sakura, Chiba
University of Fukui Hospital ( Site 0735), Eiheiji-cho,Yoshida-gun, Fukui
Hospital of the University of Occupational and Environmental Health, Japan ( Site 0746), Kitakyushu, Fukuoka
Sapporo Medical University Hospital ( Site 0726), Sapporo, Hokkaido
Hokkaido University Hospital ( Site 0756), Sapporo, Hokkaido
Kobe University Hospital ( Site 0741), Kobe, Hyogo
Kanazawa Medical University Hospital ( Site 0734), Uchinada, Ishikawa
Kagawa University Hospital ( Site 0744), Kita, Kagawa
Yokohama City University Medical Center ( Site 0733), Yokohama, Kanagawa
Mie University Hospital ( Site 0737), Tsu, Mie
National Hospital Organization Nagasaki Medical Center ( Site 0748), Ōmura, Nagasaki
Nara Medical University Hospital ( Site 0742), Kashihara, Nara
Nanbu Tokushukai Hospital ( Site 0755), Shimajiri, Okinawa
Kansai Medical University Hospital ( Site 0739), Hirakata, Osaka
Bell Land General Hospital ( Site 0740), Sakai, Osaka
The University of Osaka Hospital ( Site 0738), Suita, Osaka
Saga-Ken Medical Centre Koseikan ( Site 0747), Saga-shi, Saga
Nihon University Itabashi Hospital ( Site 0732), Itabashiku, Tokyo
The Jikei University Hospital ( Site 0731), Minato, Tokyo
Akita University Hospital ( Site 0728), Akita, Not set
Kyushu University Hospital ( Site 0745), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 0758), Fukushima, Not set
Gifu University Hospital ( Site 0736), Gifu, Not set
Hiroshima University Hospital ( Site 0743), Hiroshima, Not set
Kagoshima University Hospital ( Site 0754), Kagoshima, Not set
National Hospital Organization Kumamoto Medical Center ( Site 0749), Kumamoto, Not set
Miyazaki Prefectural Miyazaki Hospital ( Site 0752), Miyazaki, Not set
University of Miyazaki Hospital ( Site 0751), Miyazaki, Not set
Nagano Municipal Hospital ( Site 0757), Nagano, Not set
National Hospital Organization Oita Medical Center ( Site 0750), Oita, Not set
National Cancer Center-Center for Urologic Cancer ( Site 1254), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital-Urology ( Site 1253), Seongnam, Kyonggi-do
Kyungpook National University Chilgok Hospital-Urology ( Site 1252), Buk-gu, Kyongsangbuk-do
Pusan National University Yangsan Hospital ( Site 1256), Pusan, Kyongsangnam-do
Seoul National University Hospital-Urology ( Site 1251), Seoul, Not set
The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 1255), Seoul, Not set
Liepaja Regional Hospital ( Site 1553), Liepaja, Not set
Pauls Stradins Clinical Univeristy Hospital-Urological department ( Site 1551), Riga, Not set
Hospital of Lithuanian University of Health Sciences Kauno klinikos ( Site 1576), Kaunas, Kauno Apskritis
National Cancer Institute ( Site 1577), Vilnius, Vilniaus Miestas
Hospital Sultan Ismail ( Site 0905), Johor Bahru, Johor
University Malaya Medical Centre ( Site 0902), Lembah Pantai, Kuala Lumpur
Sarawak General Hospital-Radiotherapy Unit ( Site 0901), Kuching, Sarawak
National Cancer Institute ( Site 0904), Putrajaya, Wilayah Persekutuan Putrajaya
Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 0903), Kuala Lumpur, Not set
Health Pharma Professional Research S.A. de C.V: ( Site 0929), Ciudad de México, Distrito Federal
Higiea Oncologia ( Site 0938), Ciudad de México, Distrito Federal
Quemex Medical and Research ( Site 0937), Tlalpan, Distrito Federal
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0928), Guadalajara, Jalisco
Filios Alta Medicina ( Site 0931), Monterrey, Nuevo Leon
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0932), Monterrey, Nuevo Leon
Eukarya Pharmasite S.C. ( Site 0939), Monterrey, Nuevo Leon
Centro de Investigacion Clinica de Oaxaca ( Site 0934), Oaxaca de Juarez, Oaxaca
Dunedin Hospital ( Site 1032), Dunedin, Otago
Auckland City Hospital ( Site 1033), Auckland, Not set
Aliada-Oncologìa ( Site 1055), Lima, Not set
IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 1052), Lima, Not set
Oncosalud-Clinical Research ( Site 1057), Lima, Not set
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 1054), Lima, Not set
Hospital de Cascais Doutor José de Almeida ( Site 1158), Alcabideche, Lisboa
Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 1156), Vila Nova de Gaia, Porto
Unidade Local de Saude de Braga - Hospital de Braga ( Site 1151), Braga, Not set
Hospital CUF - Tejo ( Site 1157), Lisboa, Not set
Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 1153), Lisboa, Not set
Unidade Local de Saude de Santo António - Hospital Santo António ( Site 1152), Porto, Not set
Advance Urology and Laparoscopic Center ( Site 1178), Ponce, Not set
Ad-Vance Medical Research-Research ( Site 1177), Ponce, Not set
Pan American Center for Oncology Trials - Ciudadela ( Site 1176), San Juan, Not set
Spitalul Universitar de Urgență Elias ( Site 1504), București, Bucuresti
Cardiomed SRL Cluj-Napoca ( Site 1503), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL ( Site 1502), Florești, Cluj
Centrul de Oncologie "Sfântul Nectarie" ( Site 1501), Craiova, Dolj
National University Hospital ( Site 1201), Singapore, Central Singapore
National Cancer Centre Singapore ( Site 1202), Singapore, Central Singapore
Singapore General Hospital ( Site 1204), Singapore, Central Singapore
Tan Tock Seng Hospital-Medical Oncology ( Site 1203), Singapore, Central Singapore
UROEXAM ( Site 1479), Nitra, Nitriansky Kraj
Privatna Urologicka Ambulancia ( Site 1478), Trencin, Trenciansky Kraj
CANCERCARE LANGENHOVEN DRIVE ONCOLOGY CENTRE-Clinical Trials Unit ( Site 1230), Port Elizabeth, Eastern Cape
Wits Clinical Research ( Site 1234), Johannesburg, Gauteng
Wilgers Oncology Centre ( Site 1232), Pretoria, Gauteng
Curo Oncology. ( Site 1237), Pretoria, Gauteng
LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 1236), Pretoria, Gauteng
Cape Town Oncology Trials ( Site 1233), Cape Town, Western Cape
Hospital Universitari Parc Tauli-oncologia ( Site 1282), Sabadell, Barcelona
HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 1284), Barcelona, Cataluna
Institut Català d'Oncologia (ICO) - Girona ( Site 1285), Girona, Gerona
Complexo Hospitalario Universitario A Coruna ( Site 1288), A Coruna, La Coruna
Hospital Insular de Gran Canaria-Oncology ( Site 1280), Las Palmas de Gran Canaria, Las Palmas
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 1283), Pozuelo de Alarcon, Madrid
Hospital Universitario de Burgos-Oncología ( Site 1281), Burgos, Not set
Hospital Quirón Málaga ( Site 1286), Malaga, Not set
Karolinska Universitetssjukhuset Solna ( Site 1302), Stockholm, Stockholms Lan
Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1301), Uppsala, Uppsala Lan
Chi Mei Medical Center ( Site 1336), Tainan City, Tainan
Kaohsiung Veterans General Hospital ( Site 1337), Kaohsiung, Not set
Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 1331), Kaohsiung, Not set
China Medical University Hospital-Department of Urology ( Site 1335), Taichung, Not set
Taichung Veterans General Hospital ( Site 1338), Taichung, Not set
Taipei Veterans General Hospital ( Site 1332), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch-Urology ( Site 1334), Taoyuan, Not set
Maharaj Nakorn Chiang Mai Hospital ( Site 1353), Muang, Chiang Mai
Faculty of Medicine - Khon Kaen University ( Site 1351), Muang, Khon Kaen
Chulalongkorn University ( Site 1355), Bangkok, Krung Thep Maha Nakhon
Faculty of Medicine Siriraj Hospital ( Site 1356), Bangkok, Krung Thep Maha Nakhon
Songklanagarind hospital ( Site 1352), Hatyai, Songkhla
Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1379), Adana, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1376), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1377), Ankara, Not set
Koc Universitesi Hastanesi ( Site 1384), Istanbul, Not set
T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Baki-Istanbul Bakirkoy Sadi Konuk Training ( Site 1381), Istanbul, Not set
Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1383), Istanbul, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1378), Istanbul, Not set
Ege Universitesi Hastanesi-Medical Oncology ( Site 1380), Izmir, Not set
Samsun Medical Park Hastanesi-medical oncology ( Site 1382), Samsun, Not set
Addenbrooke's Hospital ( Site 1426), Cambridge, Cambridgeshire
Royal Derby Hospital ( Site 1431), Derby, Derbyshire
Torbay Hospital ( Site 1429), Torquay, Devon
Mount Vernon Cancer Centre ( Site 1440), Northwood, England
The Royal Cornwall Hospital ( Site 1430), Truro, England
The Beatson West of Scotland Cancer Centre ( Site 1428), Glasgow, Glasgow City
Charing Cross Hospital-Oncology Research ( Site 1434), London, Hammersmith And Fulham
University College London Hospital ( Site 1437), London, London, City Of
Guy's & St Thomas' NHS Foundation Trust-Oncology & Haematology Clinical Trials ( Site 1435), London, London, City Of
St. George's Hospital-Oncology ( Site 1441), London, London, City Of
GenesisCare - Oxford ( Site 1442), Oxford, Oxfordshire
GenesisCare - Windsor ( Site 1443), Windsor, Windsor And Maidenhead
The Christie NHS Foundation Trust ( Site 1436), Manchester, Not set
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms
A Study Comparing Daratumumab, VELCADE (Bortezomib), Lenalidomide, and Dexamethasone (D-VRd) With VELCADE, Lenalidomide, and Dexamethasone (VRd) in Participants With Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy
Active Not Recruiting
The purpose of this study to determine if the addition of daratumumab to bortezomib + lenalidomide + dexamethasone (VRd) will improve overall minimal residual disease (MRD) negativity rate compared with VRd alone.
The purpose of this study to determine if the addition of daratumumab to bortezomib + lenalidomide + dexamethasone (VRd) will improve overall minimal residual disease (MRD) negativity rate compared with VRd alone. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Innovative Clinical Research Inc, Cerritos, California +113 locations
Innovative Clinical Research Inc, Cerritos, California
Baptist MD Anderson, Jacksonville, Florida
Fort Wayne Medical Oncology and Hematology, Inc., Fort Wayne, Indiana
Norton Healthcare, Louisville, Kentucky
Tufts Medical Center, Boston, Massachusetts
Boston University Medical Center, Boston, Massachusetts
Cancer And Hematology Centers of Western Michigan PC, Grand Rapids, Michigan
Saint Lukes Hospital Saint Lukes Cancer Specialists, Kansas City, Missouri
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
San Juan Oncology Associates, Farmington, New Mexico
Roswell Park Cancer Institute, Buffalo, New York
NYU Winthrop, Mineola, New York
Levine Cancer Institute, Charlotte, North Carolina
Cleveland Clinic, Cleveland, Ohio
Good Samaritan Hospital Corvallis, Corvallis, Oregon
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Gibbs Cancer Center, Spartanburg, South Carolina
University of Texas, MD Anderson Cancer Center, Houston, Texas
University of Virginia, Charlottesville, Virginia
Universidade Estadual De Campinas, Campinas, Not set
Liga Norte Riograndense Contra O Cancer, Natal, Not set
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS, Porto Alegre, Not set
Ministerio da Saude Instituto Nacional do Cancer, Rio de Janeiro, Not set
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro, Not set
Instituto de Ensino e Pesquisa São Lucas, Sao Paulo, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia, Sao Paulo, Not set
Instituto Brasileiro de Controle do Cancer - Sao Camilo Oncologia, Sao Paulo, Not set
Clinica Medica Sao Germano S/S LTDA, Sao Paulo, Not set
Hospital Santa Cruz, São Paulo, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
The Gordon & Leslie Diamond Health Care Center, Vancouver, British Columbia
QEII Health Sciences Centre, Halifax, Nova Scotia
Brampton Civic Hospital, Brampton, Ontario
Victoria Hospital, London, Ontario
Lakeridge Health Oshawa, Oshawa, Ontario
McGill University Health Centre, Montreal, Quebec
CHU de Quebec L Hotel Dieu de Quebec, Quebec, Not set
Fakultni nemocnice Brno, Brno, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni Nemocnice Ostrava, Ostrava, Not set
Fakultni nemocnice Plzen, Hemato-onkologicke oddeleni, Plzen, Not set
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
CHU Henri Mondor, Creteil N/a, Not set
Centre Hospitalier Départmental La Roche sur Yon, La Roche sur Yon Cedex 9, Not set
Hopital Claude Huriez, Lille, Not set
Institut Paoli Calmettes, Marseille Cedex 9, Not set
CHU de Montpellier Hopital Saint Eloi, Montpellier, Not set
CHU de Bordeaux - Hospital Haut-Leveque, Pessac cedex, Not set
Strasbourg Oncologie Libérale, Strasbourg, Not set
Institut Universitaire du cancer de Toulouse-Oncopole, Toulouse cedex 9, Not set
phase 3 - Hämatoonkologischer Studienkreis am Klinikum Aschaffenburg, Aschaffenburg, Not set
Universitatsklinikum Freiburg, Freiburg, Not set
St. Josef-Krankenhaus Hamm-Bockum-Hövel, Hamm, Not set
Institut für Versorgungsforschung, Koblenz, Not set
Universitatsmedizin Leipzig, Leipzig, Not set
Klinikum Großhadern der Ludwig-Maximilians-Universität, München, Not set
Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,, Tuebingen, Not set
Barzilai Medical Center, Ashkelon, Not set
Hillel Yaffe Medical Center, Hadera, Not set
Rambam Med.Center - Hematology Institute, Haifa, Not set
Carmel Medical Center, Haifa, Not set
Meir Hospital, Kfar Saba, Not set
Rabin Medical Center, Petah-Tiqva, Not set
Sheba Medical Center, Ramat Gan, Not set
Sourasky (Ichilov) Medical Center, Tel Aviv, Not set
Fukuoka University Hospital, Fukuoka, Not set
Ogaki Municipal Hospital, Gifu, Not set
Kanazawa University Hospital, Kanazawa, Not set
Kobe City Medical Center General Hospital, Kobe City, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto shi, Not set
University Hospital Kyoto Prefectural University of Medicine, Kyoto, Not set
National Hospital Organization Matsumoto Medical Center, Matsumoto, Not set
Matsuyama Red Cross Hospital, Matsuyama, Not set
Nagoya City University Hospital, Nagoya, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Japanese Red Cross Osaka Hospital, Osaka, Not set
National Hospital Organization Shibukawa Medical Center, Shibukawa, Not set
Japanese Red Cross Medical Center, Shibuya, Not set
VU Medisch Centrum, Amsterdam, Not set
Albert Schweitzer ziekenhuis-lokatie Dordwijk, Dordrecht, Not set
Erasmus MC, Rotterdam, Not set
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozow, Not set
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich, Chorzow, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce, Not set
NSSU Szpital Uniwersytecki w Krakowie, Krakow, Not set
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli, Lublin, Not set
Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan, Not set
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka, Slupsk, Not set
Instytut Hematologii i Transfuzjologii, Warszawa, Not set
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warszawa, Not set
Hosp. Univ. Fundacion Alcorcon, Alcorcon, Not set
Hosp. Del Mar, Barcelona, Not set
Hosp. Univ. de Guadalajara, Guadalajara, Not set
Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda, Not set
Hosp. Quiron Madrid Pozuelo, Pozuelo de Alarcon, Not set
Hosp. Mutua Terrassa, Terrassa, Not set
Gulhane Egitim ve Arastirma Hastanesi, Ankara, Not set
Hacettepe University Medical Faculty, Ankara, Not set
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Not set
Ankara University School of Medicine Cebeci Hospital, Ankara, Not set
Istanbul University Istanbul Medical Faculty, Istanbul, Not set
Dokuz Eylul University Medical Faculty, Izmir, Not set
Ondokuz Mayis University, Samsun, Not set
Monklands District General Hospital, Airdrie, Not set
Blackpool Victoria Hospital, Blackpool, Not set
University Hospital Wales, Cardiff, Not set
Colchester Hospital University NHS, Colchester, Not set
Leicester Royal Infirmary - Haematology, Leicester, Not set
Altnagelvin Hospital, Londonderry, Not set
The Royal Oldham Hospital, Oldham, Not set
Derriford Hospital, Plymouth, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Multiple Myeloma
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
Recruiting
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug.
The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM.
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug.
The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +96 locations
Banner MD Anderson Cancer Center, Gilbert, Arizona
USC/Norris Comprehensive Cancer Center, Los Angeles, California
University of California, Davis Comprehensive Cancer Center, Sacramento, California
UC San Diego Moores Cancer Center, San Diego, California
University of California San Francisco Medical Center, San Francisco, California
UCLA Department of Medicine-Hematology/Oncology, Santa Monica, California
Stanford Cancer Institute, Stanford, California
Colorado Blood Cancer Institute, Denver, Colorado
Moffitt Cancer Center, Tampa, Florida
Winship Cancer Institute, Atlanta, Georgia
IU Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana
Norton Cancer Institute, St. Matthews Campus, Louisville, Kentucky
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
University of Michigan, Ann Arbor, Michigan
Corewell Health - Lemmen-Holton Cancer Pavilion, Grand Rapids, Michigan
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York
Novant Health Cancer Institute Hematology, Charlotte, North Carolina
Novant Health Cancer Institute Hematology- Forsyth, Winston-Salem, North Carolina
University of Cincinnati Medical Center, Cincinnati, Ohio
Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio
Oregon Health and Science University, Portland, Oregon
University of Tennessee Medical Center, Knoxville, Tennessee
Baptist Cancer Center, Memphis, Tennessee
Henry-Joyce Cancer Clinic, Nashville, Tennessee
St. David's South Austin Medical Center, Austin, Texas
Houston Methodist Hospital Cancer Center, Houston, Texas
The University of Texas MD Anderson Cancer Center, Houston, Texas
Huntsman Cancer Institute, Salt Lake City, Utah
LDS Hospital, Salt Lake City, Utah
Swedish Cancer Institute, Seattle, Washington
University of Washington Medical Center, Seattle, Washington
Royal Prince Alfred Hospital, Camperdown, New South Wales
Royal North Shore Hospital, St. Leonards, New South Wales
Royal Adelaide Hospital, Adelaide, South Australia
Epworth HealthCare, Richmond, Victoria
Sir Charles Gairdner Hospital, Nedlands, Western Australia
Ordensklinikum Linz GmbH Elisabethinen, Hamatologie mit Stammzelltransplantation, Hamostaseologie und medizinische Onkologie, Linz, Not set
Paracelsus Medizinischen Privatuniversitaet, Salzburg, Not set
University Hospital St. Poelten, Department of Internal Medicine I, St. Poelten, Not set
Medical University of Vienna, Wien, Not set
Cliniques Universitaires Saint-Luc, Brussels, Not set
University Hospital of Antwerp, Edegem, Not set
UZ Leuven, Flemish Brabant, Not set
UZ Gent, Gent Oost-Vlaanderen, Not set
QEII Health Sciences Centre, Halifax, Not set
University Health Network - The Princess Margaret Cancer Centre, Toronto, Not set
CHU de Lille- Hopital Claude Huriez, Lille, Not set
Institut Paoli Calmettes, Marseille, Not set
CHU De Montpellier - Hopital Saint Eloi, Montpellier, Not set
Centre Hospitalier Universitaire de Nantes, Nantes, Not set
Hopital Saint Louis, Paris, Not set
Hopital Saint Antoine, Paris, Not set
Hôpital Lyon Sud, Pierre-Benite, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
CHU de Rennes, Rennes, Not set
CHU de Toulouse. IUCT Oncopole, Toulouse, Not set
Universitatsklinikum Hamburg Eppendorf, Hamburg, Not set
Universitatsklinikum Koln, Klinik I fOr lnnere Medizin, Köln, Not set
Universitatsklinikum Leipzig, Leipzig, Not set
TUM Klinikum, Rechts der Isar, Klinik und Poliklinik fur Innere Medizin III, Hamatologie und Onkologie, München, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, MI
IRCCS AOU di Bologna, Bologna, Not set
Ospedale San Raffaele, Milano, Not set
AOU Città della Salute e della Scienza Presidio Ospedaliero Molinette, Torino, Not set
Hyogo Medical University Hospital, Hyogo, Not set
Nagoya City University Hospital, Nagoya City, Not set
The University of Osaka Hospital, Osaka, Not set
Hamamatsu University Hospital, Shizuoka, Not set
Jichi Medical University Hospital, Tochigi, Not set
Juntendo University School of Medicine Juntendo Clinic, Tokyo, Not set
Japanese Red Cross Medical Center, Tokyo, Not set
Amsterdam UMC - Location vUmc, Amsterdam, Not set
University Medical Center Groningen, Groningen, Not set
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wroclaw, Not set
ICO Badalona-H.U. Germans Trias i Pujol, Badalona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital Duran i Reynals, Barcelona, Not set
Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital Universitario Ramon Y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Clinica Universidad de Navarra, Pamplona, Not set
Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Universitario Virgen del Rocio, Seville, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Inselspital - Universitätsspital Bern, Berne, Not set
Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
University Hospitals Bristol NHS Foundation Trust, Bristol Haematology and Oncology Centre, Bristol, Not set
University Hospital of Wales, Cardiff, Not set
Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, Not set
King's College Hospital, London, Not set
University College London Hospital, London, Not set
Newcastle Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle, Not set
Conditions: Multiple Myeloma
Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)
Recruiting
The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs).
The primary hypotheses of this study are that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pe... Read More
The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs).
The primary hypotheses of this study are that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pemetrexed and carboplatin) in regard to progression-free survival (PFS) and overall survival (OS). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Kaiser Permanente - Oakland ( Site 0054), Oakland, California +152 locations
Kaiser Permanente - Oakland ( Site 0054), Oakland, California
Kaiser Permanente - Roseville ( Site 0055), Roseville, California
Kaiser Permanente - San Francisco ( Site 0056), San Francisco, California
Kaiser Permanente - Santa Clara ( Site 0057), Santa Clara, California
Kaiser Permanente-Kaiser Permanente ( Site 0036), Vallejo, California
Kaiser Permanente - Walnut Creek ( Site 0058), Walnut Creek, California
Mid Florida Hematology and Oncology Center ( Site 0005), Orange City, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0003), Marietta, Georgia
University of Michigan ( Site 0009), Ann Arbor, Michigan
Cox Medical Center North - Cox Medical Center/ Hematology/Medical Oncology ( Site 0051), Springfield, Missouri
Astera Cancer Care ( Site 0032), East Brunswick, New Jersey
Stony Brook University-Cancer Center ( Site 0038), Stony Brook, New York
Sanford Fargo Medical Center ( Site 0028), Fargo, North Dakota
Sanford Cancer Center ( Site 0024), Sioux Falls, South Dakota
Millennium Research & Clinical Development ( Site 0035), Houston, Texas
Clinica Adventista Belgrano-Oncology ( Site 0315), Caba., Buenos Aires
Instituto Alexander Fleming ( Site 0307), Ciudad Autónoma de Buenos Aires, Buenos Aires
Hospital Británico de Buenos Aires-Oncology ( Site 0304), Ciudad autónoma de Buenos Aires, Caba
Centro Privado de RMI Río Cuarto S.A. II ( Site 0310), Río Cuarto, Cordoba
Instituto de Oncología de Rosario ( Site 0301), Rosario, Santa Fe
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0303), La Rioja, Not set
Cross Cancer Institute ( Site 0201), Edmonton, Alberta
Waterloo Regional Health Network (WRHN) ( Site 0207), Kitchener, Ontario
Princess Margaret Cancer Centre ( Site 0203), Toronto, Ontario
McGill University Health Centre ( Site 0204), Montréal, Quebec
Anhui Provincial Cancer Hospital ( Site 3132), Hefei, Anhui
Beijing Cancer hospital ( Site 3100), Beijing, Beijing
Beijing Peking Union Medical College Hospital-pneumology department ( Site 3107), Beijing, Beijing
Chongqing University Cancer Hospital-Medical Oncology ( Site 3128), Chongqing, Chongqing
Fujian Cancer Hospital ( Site 3124), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University ( Site 3125), XiaMen, Fujian
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 3102), Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital-Respiratory Oncology ( Site 3103), Nanning, Guangxi
Harbin Medical University Cancer Hospital ( Site 3109), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 3105), Zhengzhou, Henan
Tongji Hospital Tongji Medical,Science & Technology ( Site 3121), Wuhan, Hubei
Hubei Cancer Hospital ( Site 3122), Wuhan, Hubei
The Second Xiangya Hospital of Central South University-Oncology ( Site 3104), Changsha, Hunan
Nanjing Drum Tower Hospital JiangBei International Branch Hospital ( Site 3117), Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University-Respiratory Department ( Site 3118), Suzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University ( Site 3119), Nanchang, Jiangxi
The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 3130), XI An, Shaanxi
Jinan Central Hospital ( Site 3113), Jinan, Shandong
Shandong Cancer Hospital ( Site 3112), Jinan, Shandong
Zhongshan Hospital of Fudan University ( Site 3133), Shanghai, Shanghai
Shanxi Cancer Hospital ( Site 3114), Taiyuan, Shanxi
West China Hospital, Sichuan University ( Site 3126), Cheng Du, Sichuan
Sichuan Cancer hospital. ( Site 3127), Chengdu, Sichuan
The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3101), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 3106), Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 3120), Wenzhou, Zhejiang
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0601), Valledupar, Cesar
IMAT S.A.S ( Site 0602), Monteria, Cordoba
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0600), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0606), Bogota, Distrito Capital De Bogota
Oncologos del Occidente ( Site 0604), Pereira., Risaralda
Fundacion Valle del Lili- CIC-Oncology CIC ( Site 0605), Cali, Valle Del Cauca
Nouvel Hôpital Civil (NHC) ( Site 1302), Strasbourg, Alsace
Clinique Clairval ( Site 1306), Marseille, Bouches-du-Rhone
Gustave Roussy ( Site 1303), Villejuif, Ile-de-France
Hopitaux Universitaires Paris Centre-Hopital Cochin-Unité d'Oncologie Thoracique ( Site 1304), Paris, Not set
All India Institute of Medical Sciences-Department of medical oncology ( Site 3303), New Delhi, Delhi
Indraprastha Apollo Hospitals-APOLLO RESEARCH INNOVATION ( Site 3301), New Delhi, Delhi
Rajiv Gandhi Cancer Institute And Research Centre ( Site 3300), New Delhi, Delhi
Artemis hospital ( Site 3307), Gurugram, Haryana
Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute-Centre for cancer ( Site 3302), Mumbai, Maharashtra
Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1803), Milano, Lombardia
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1800), Milan, Lombardia
Instituto Tumori Giovanni Paolo II-SSD Oncologia Medica per la Patologia Toracica ( Site 1802), Bari, Puglia
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1804), Firenze, Toscana
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1801), Roma, Not set
Fujita Health University Hospital ( Site 3409), Toyoake, Aichi
Ehime University Hospital ( Site 3411), Toon, Ehime
National Hospital Organization Kyushu Cancer Center ( Site 3401), Fukuoka,, Fukuoka
Gunma Prefectural Cancer Center ( Site 3413), Ota, Gunma
Kanazawa University Hospital ( Site 3402), Kanazawa, Ishikawa
St. Marianna University Hospital ( Site 3415), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 3416), Yokohama, Kanagawa
Miyagi Cancer Center ( Site 3406), Natori, Miyagi
Kansai Medical University Hospital ( Site 3414), Hirakata, Osaka
Saitama Prefectural Cancer Center ( Site 3417), Kitaadachi-gun, Saitama
Shizuoka Cancer Center ( Site 3405), Sunto-gun, Shizuoka
National Cancer Center Hospital ( Site 3408), Chuo, Tokyo
Toho University Omori Medical Center ( Site 3407), Ota, Tokyo
Kyushu University Hospital ( Site 3400), Fukuoka, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 3419), Hiroshima, Not set
Niigata Cancer Center Hospital ( Site 3403), Niigata, Not set
Okayama University Hospital ( Site 3404), Okayama, Not set
Osaka International Cancer Institute ( Site 3410), Osaka, Not set
Osaka Metropolitan University Hospital ( Site 3412), Osaka, Not set
Chungbuk National University Hospital ( Site 3804), Cheongju-si, Chungbuk
National Cancer Center ( Site 3803), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 3807), Seongnam, Kyonggi-do
The Catholic University Of Korea St. Vincent's Hospital ( Site 3800), Suwon-si, Kyonggi-do
Ajou University Hospital ( Site 3813), Suwon, Kyonggi-do
Pusan National University Yangsan Hospital ( Site 3802), Pusan, Kyongsangnam-do
Pusan National University Hospital ( Site 3805), Busan, Pusan-Kwangyokshi
Keimyung University Dongsan Hospital CRC room 1 ( Site 3814), Daegu, Taegu-Kwangyokshi
Chungnam national university hospital ( Site 3806), Jung-gu, Taejon-Kwangyokshi
The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3812), Seoul, Not set
Asan Medical Center ( Site 3810), Seoul, Not set
Samsung Medical Center ( Site 3811), Seoul, Not set
Korea University Guro Hospital ( Site 3808), Seoul, Not set
University Malaya Medical Centre ( Site 3507), Lembah Pantai, Kuala Lumpur
National Cancer Institute-Radiotherapy and Oncology ( Site 3504), Putrajaya, Kuala Lumpur
Hospital Tengku Ampuan Afzan ( Site 3506), Kuantan, Pahang
Hospital Pulau Pinang-Oncology, radiotherapy and palliat ( Site 3501), George Town, Pulau Pinang
Sarawak General Hospital-Radiotherapy Unit ( Site 3508), Kuching, Sarawak
Arké SMO S.A. de C.V. ( Site 0706), Mexico, Distrito Federal
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0700), Guadalajara, Jalisco
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0705), Monterrey, Nuevo Leon
Centro de Investigacion Clinica de Oaxaca ( Site 0704), Oaxaca de Juarez, Oaxaca
Oaxaca Site Management Organization S.C. ( Site 0701), Oaxaca, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2003), Bydgoszcz, Kujawsko-pomorskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2000), Warszawa, Mazowieckie
Bialostockie Centrum Onkologii ( Site 2010), Bialystok, Podlaskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach-II Klinika Radioterapi i Chemioterapii ( Site 2002), Gliwice, Slaskie
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2321), LHospitalet de Llobregat, Barcelona
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2322), Santiago de compostela, La Coruna
Hospital Universitario Juan Ramon Jimenez-Oncología Medica ( Site 2323), Huelva, Not set
Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2324), Sevilla, Not set
Karolinska Universitetssjukhuset Solna ( Site 2401), Stockholm, Stockholms Lan
National Cheng Kung University Hospital ( Site 3901), Tainan City, Tainan
Chi Mei Hospital - Liouying Branch ( Site 3909), Tainan City, Tainan
National Taiwan University Cancer Center (NTUCC) ( Site 3907), Taipei City, Taipei
Changhua Christian Hospital ( Site 3904), Changhua, Not set
National Taiwan University Hospital - Hsinchu branch ( Site 3900), Hsinchu, Not set
Chang Gung Memorial Hospital at Kaohsiung ( Site 3905), Kaohsiung, Not set
Far Eastern Memorial Hospital ( Site 3912), New Taipei, Not set
Taichung Veterans General Hospital-Chest ( Site 3910), Taichung, Not set
National Taiwan University Hospital-Oncology ( Site 3908), Taipei, Not set
Mackay Memorial Hospital-Chest Medicine ( Site 3902), Taipei, Not set
Taipei Medical University Hospital ( Site 3903), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 3911), Taoyuan, Not set
Maharaj Nakorn Chiang Mai Hospital ( Site 4005), Muang, Chiang Mai
Faculty of Medicine - Khon Kaen University ( Site 4002), Muang, Khon Kaen
Faculty of Medicine Siriraj Hospital ( Site 4004), Bangkok, Krung Thep Maha Nakhon
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 4006), Dusit, Krung Thep Maha Nakhon
Ramathibodi Hospital ( Site 4001), Ratchathewi, Krung Thep Maha Nakhon
Lampang Cancer Hospital ( Site 4000), Mueang Lampang, Lampang
Songklanagarind hospital ( Site 4003), HatYai, Songkhla
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2504), Adana, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 2501), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 2505), Ankara, Not set
Ankara Bilkent Şehir Hastanesi ( Site 2500), Ankara, Not set
I.E.U. Medical Point Hastanesi-Oncology ( Site 2503), Izmir, Not set
Hanoi Oncology Hospital ( Site 4198), Hanoi, Ha Noi
K Hospital - National Cancer Hospital ( Site 4193), Hanoi, Ha Noi
National Lung Hospital-Oncology Department ( Site 4194), Hanoi, Ha Noi
Thong Nhat Hospital ( Site 4192), Tan Binh District, Ho Chi Minh
Cho Ray Hospital ( Site 4190), Ho Chi Minh, Not set
Ho Chi Minh City Oncology Hospital - Tan Phu Ward ( Site 4191), Ho Chi Minh, Not set
Tam Anh Hospital ( Site 4196), Ho Chi Minh, Not set
Conditions: Non-small Cell Lung Cancer (NSCLC)
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