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Paclitaxel Treatment Options in Canada
A collection of 344 research studies where Paclitaxel is the interventional treatment. These studies are located in the Canada . Paclitaxel is used for conditions such as Breast Cancer, Ovarian Cancer and Non-Small Cell Lung Cancer.
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A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer
Recruiting
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with defactinib versus Investigator's choice of treatments (ICT) in subjects with recurrent LGSOC who have progressed on a prior platinum-based therapy.
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with defactinib versus Investigator's choice of treatments (ICT) in subjects with recurrent LGSOC who have progressed on a prior platinum-based therapy. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: HonorHealth, Phoenix, Arizona +101 locations
HonorHealth, Phoenix, Arizona
University of Arkansas, Little Rock, Arkansas
UCLA Health, Los Angeles, California
UC Davis, Sacramento, California
University of California, San Francisco, San Francisco, California
Yale University, New Haven, Connecticut
Florida Cancer Specialists - South, Fort Myers, Florida
Mount Sinai, Miami Beach, Florida
AdventHealth, Orlando, Florida
Moffitt Cancer Center, Tampa, Florida
Florida Cancer Specialists Research East, West Palm Beach, Florida
Winship Cancer Institute at Emory University, Atlanta, Georgia
NorthShore University HealthSystem, Evanston, Illinois
Louisiana State University, New Orleans, Louisiana
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland
Karmanos Cancer Center, Detroit, Michigan
Minnesota Oncology Hematology, Minneapolis, Minnesota
Washington University School of Medicine, Saint Louis, Missouri
Roswell Park Cancer Institute, Buffalo, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Atrium Health, Charlotte, North Carolina
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State, Hilliard, Ohio
University of Oklahoma Medical Center, Oklahoma City, Oklahoma
Willamette Valley Cancer Institute, Eugene, Oregon
Northwest Cancer Specialists, Portland, Oregon
Asplundh Cancer Pavilion | Jefferson Health, Philadelphia, Pennsylvania
Allegheny Health Network, Pittsburgh, Pennsylvania
Texas Oncology Central, Austin, Texas
Texas Oncology-Fort Worth Cancer Center, Fort Worth, Texas
Houston Methodist, Houston, Texas
MD Anderson Cancer Center, Houston, Texas
Texas Oncology, San Antonio, Texas
Texas Oncology, The Woodlands, Texas
Texas Oncology, Tyler, Texas
Intermountain Medical Center, Murray, Utah
University of Virginia Health System, Charlottesville, Virginia
Virginia Cancer Specialists, PC, Gainesville, Virginia
Prince of Wales Hospital, Randwick, New South Wales
Icon Cancer Centre Wesley, Auchenflower, Queensland
Cancer Research South Australia, Adelaide, South Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria
Sir Charles Gairdner Hospital, Nedlands, Western Australia
UZA, Edegem, Not set
University Hospital Ghent, Ghent, Not set
Princess Margaret Cancer Center, Toronto, Ontario
McGill University Health Centre, Montreal, Quebec
Centre Hospitalier de l'Universite de Montreal (CHUM), Montréal, Quebec
British of Columbia, Vancouver, Not set
Aalborg U.H, Aalborg, Not set
Centre Hospitalier de Besançon, Besançon, Not set
Site Georges François Leclerc, Dijon, Not set
Centre Oscar Lambret, Lille, Not set
Centre Léon Bérard, Lyon, Not set
Institut Curie, Paris, Not set
Agaplesion Markus Krankenhaus, Frankfurt, Hessen
Charité - Universitätsmedizin Berlin, Berlin, Not set
Universitätsklinikum Carl Gustav Carus, Dresden, Not set
Kliniken Essen-Mitte, Essen, Not set
UMC Hamburg-Eppendorf, Hamburg, Not set
Universitätsklinikum Mannheim GmbH, Mannheim, Not set
Universitätsfrauenkinik Ulm, Ulm, Not set
St. James's Hospital, Dublin, Not set
Centro di Riferimento Oncologico (CRO), Aviano, Not set
Spedali Civili, Brescia, Not set
AO Cannizzaro, Catania, Not set
Istituto Nazionale dei Tumori, Milano, Not set
San Raffaele Hospital, Milan, Not set
Humanitas San Pio X, Milan, Not set
European Institute of Oncology (IEO), Milan, Not set
INT Napoli Hospital, Napoli, Not set
Istituto Oncologico Veneto (IOV), Padova, Not set
IRCCS Gemelli, Roma, Not set
Istituti Fisioterapici Ospitalieri, Rome, Not set
S.C.D.U. Oncologia, Torino, Not set
Osaka Medical Center, Osaka, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
Yonsei University Severance Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Gangnam Severance Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Netherlands Cancer Insitute, Amsterdam, Not set
Radboud UMC, Nijmegen, Not set
Auckland City Hospital, Auckland, Not set
Białostockie Centrum Onkologii, Białystok, Not set
Gdański Uniwersytet Medyczny, Gdańsk, Not set
Siedleckie Centrum Onkologii, Siedlce, Not set
Clínico Virgen de La Arrixaca, El Palmar, Murcia
H. de Donostia, Donostia, San Sebastian
H. Vall d´ Hebron, Barcelona, Not set
Hospital Universitario Reina Sofía, Córdoba, Not set
H.U. Ramón y Cajal, Madrid, Not set
Hospital Clínico Universitario de Santiago, Santiago de Compostela, Not set
Hospital Clínico Universitario de Valencia, Valencia, Not set
Greater Glasgow and Clyde (GGC), Glasgow, Scotland
Cambridge University Hospital, Cambridge, Not set
University of Edinburgh Cancer Research Centre, Edinburgh, Not set
Hope Cancer Trials Centre, Leicester, Not set
University College London Hospitals NHS Foundation Trust, London, Not set
Royal Marsden Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Royal Marsden Hospital, Sutton, Not set
Conditions: Low Grade Serous Ovarian Cancer
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
Active Not Recruiting
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/22/2025
Locations: Research Site, Boston, Massachusetts +67 locations
Research Site, Boston, Massachusetts
Research Site, Boston, Massachusetts
Research Site, New York, New York
Research Site, Oklahoma City, Oklahoma
Research Site, Houston, Texas
Research Site, Heidelberg, Not set
Research Site, Melbourne, Not set
Research Site, Vancouver, British Columbia
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Harbin, Not set
Research Site, Jining, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Taiyuan, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Brno, Not set
Research Site, Praha, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Milano, Not set
Research Site, Milan, Not set
Research Site, Modena, Not set
Research Site, Napoli, Not set
Research Site, Padova, Not set
Research Site, Roma, Not set
Research Site, Chuo-ku, Not set
Research Site, Koto-ku, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Bydgoszcz, Not set
Research Site, Gdańsk, Not set
Research Site, Gdynia, Not set
Research Site, Grzepnica, Not set
Research Site, Toruń, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Barcelona, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Pozuelo de Alarcon, Not set
Research Site, Sevilla, Not set
Research Site, Chernivtsі, Not set
Research Site, Ivano-Frankivsk, Not set
Research Site, Kyiv, Not set
Research Site, Uzhgorod, Not set
Research Site, Cambridge, Not set
Research Site, Manchester, Not set
Research Site, Oxford, Not set
Research Site, Sutton, Not set
Conditions: Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer, Additional Indications Below for Module 4 and 5, Non-small Cell Lung Cancer, Colorectal Cancer, Bladder Cancer, Gastric Cancer, Biliary Cancer, Cervical Cancer, Endometrial Cancer, Small Cell Lung Cancer Only in Module 5
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014)
Active Not Recruiting
The purpose of this study is to assess the efficacy and safety of pembrolizumab plus lenvatinib plus chemotherapy compared with pembrolizumab plus chemotherapy as first-line intervention in participants with metastatic esophageal carcinoma.
The primary hypotheses are that pembrolizumab plus lenvatinib plus chemotherapy is superior to pembrolizumab plus chemotherapy with respect to overall survival (OS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by blinded independ... Read More
The purpose of this study is to assess the efficacy and safety of pembrolizumab plus lenvatinib plus chemotherapy compared with pembrolizumab plus chemotherapy as first-line intervention in participants with metastatic esophageal carcinoma.
The primary hypotheses are that pembrolizumab plus lenvatinib plus chemotherapy is superior to pembrolizumab plus chemotherapy with respect to overall survival (OS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by blinded independent central review (BICR). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: City of Hope ( Site 0102), Duarte, California +197 locations
City of Hope ( Site 0102), Duarte, California
MedStar Washington Hospital Center ( Site 0186), Washington, District of Columbia
James Graham Brown Cancer Center ( Site 0117), Louisville, Kentucky
Norton Cancer Institute ( Site 0116), Louisville, Kentucky
Johns Hopkins Bayview Medical Center ( Site 0152), Baltimore, Maryland
UMASS Memorial Medical Center ( Site 0120), Worcester, Massachusetts
Capital Health Medical Center - Hopewell ( Site 0189), Pennington, New Jersey
Hematology-Oncology Associates of CNY ( Site 0173), East Syracuse, New York
Memorial Sloan Kettering Cancer Center ( Site 0132), New York, New York
Weill Cornell Medical College ( Site 0133), New York, New York
St. Luke's University Health Network ( Site 0185), Bethlehem, Pennsylvania
AHN Allegheny General Hospital ( Site 0164), Pittsburgh, Pennsylvania
Medical University of South Carolina-Hollings Cancer Center ( Site 0177), Charleston, South Carolina
VCU Health Adult Outpatient Pavillion ( Site 0160), Richmond, Virginia
Seattle Cancer Care Alliance ( Site 0145), Seattle, Washington
Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0203), Berazategui, Buenos Aires
IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 0202), Caba, Buenos Aires
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0205), Mar del Plata., Buenos Aires
Fundacion Estudios Clinicos-Oncology ( Site 0215), Rosario, Santa Fe
Sanatorio Parque ( Site 0206), Rosario, Santa Fe
Hospital Provincial del Centenario ( Site 0217), Rosario, Santa Fe
Fundacion Favaloro ( Site 0201), Buenos Aires, Not set
Fundación Respirar ( Site 0216), Buenos Aires, Not set
Hospital Italiano de Córdoba ( Site 0218), Cordoba, Not set
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0221), La Rioja, Not set
Instituto San Marcos ( Site 0213), San Juan, Not set
CancerCare Manitoba ( Site 0001), Winnipeg, Manitoba
Princess Margaret Cancer Centre ( Site 0004), Toronto, Ontario
Hotel-Dieu de Levis ( Site 0013), Levis, Quebec
Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 0401), Temuco., Araucania
James Lind Centro de Investigacion del Cancer ( Site 0412), Temuco, Araucania
Fundacion Arturo Lopez Perez FALP ( Site 0403), Santiago, Region M. De Santiago
Oncovida ( Site 0413), Santiago, Region M. De Santiago
Clínica San Carlos de Apoquindo Red Salud UC Christus ( Site 0407), Santiago, Region M. De Santiago
Bradford Hill Centro de Investigaciones Clinicas ( Site 0404), Santiago, Region M. De Santiago
Anhui Provincial Cancer Hospital ( Site 8058), Hefei, Anhui
The Second Affiliated Hospital of Anhui Medical University ( Site 8026), Hefei, Anhui
Beijing Cancer Hospital ( Site 8001), Beijing, Beijing
Fujian Provincial Cancer Hospital ( Site 8029), Fuzhou, Fujian
The First Affiliated Hospital of Xiamen University ( Site 8003), Xiamen City, Fujian Province, Fujian
Zhongshan Hospital Affiliated to Xiamen University ( Site 8055), Xiamen, Fujian
The First Affiliated Hospital.Sun Yat-sen University ( Site 8047), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital ( Site 8031), Guangzhou, Guangdong
The Third Xiangya Hospital of Central South University ( Site 8046), Changsha, Hainan
The First Affiliated Hospital of Hainan Medical University ( Site 8042), Haikou, Hainan
Affiliated Hospital of Chengde Medical Univeristy ( Site 8053), Chengde, Hebei
Harbin Medical University Cancer Hospital ( Site 8009), Harbin, Heilongjiang
Anyang Cancer Hospital ( Site 8006), Anyang, Henan
The First Affiliated Hospital of Henan University of Science &Technology-Tumor ( Site 8036), Luoyang, Henan
The First Affiliated Hospital of Xinxiang Medical University ( Site 8018), Xinxiang, Henan
Tongji Medical College Huazhong Uinversity Of Science and Technology ( Site 8025), Wuhan, Hubei
Hubei Cancer Hospital ( Site 8014), Wuhan, Hubei
Affiliated hospital of Jiangnan university ( Site 8049), Wuxi, Jiangsu
The Affiliated Hospital of Xuzhou Medical University ( Site 8015), Xuzhou, Jiangsu
Jilin Cancer Hospital ( Site 8016), Changchun, Jilin
Jinan Central Hospital ( Site 8052), Jinan, Shandong
Shandong Cancer Hospital ( Site 8060), Jinan, Shandong
Affiliated Hospital of Jining Medical University ( Site 8017), Jining, Shandong
Linyi Cancer Hospital- Medical Oncology Department ( Site 8051), Linyi, Shandong
Shanxi Provincial Cancer Hospital ( Site 8019), Taiyuan, Shanxi
West China Hospital of Sichuan University ( Site 8048), Chengdu, Sichuan
Tianjin Medical University Cancer Institute & Hospital ( Site 8035), Tianjin, Tianjin
The Affiliated Cancer Hospital of Xinjiang Medical University. ( Site 8041), Urumqi, Xinjiang
Sir Run Run Shaw Hospital ( Site 8021), Hangzhou, Zhejiang
ICIMED-Oncology Research Unit ( Site 0903), San José, San Jose
PROCLINICAL Pharma ( Site 0904), San José, San Jose
CIMCA Centro de Investigacion y Manejo del Cancer ( Site 0902), San Jose, Not set
Onco Tech S A ( Site 0901), San Jose, Not set
Rigshospitalet ( Site 2102), Copenhagen, Hovedstaden
Odense University Hospital ( Site 2101), Odense, Syddanmark
Institut De Cancerologie De Lorraine ( Site 1010), Vandoeuvre les Nancy, Ain
Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1014), Strasbourg, Alsace
Centre François Baclesse ( Site 1009), Caen, Calvados
Centre Georges Francois Leclerc ( Site 1008), Dijon, Cote-d Or
C.H. regional Unv. de Brest - Hopital La Cavale Blanche - Institut de Cancerologie et d Imagerie ( S, Brest, Finistere
CHU Besançon ( Site 1015), Besançon, Franche-Comte
CHU Bordeaux Haut-Leveque ( Site 1012), Pessac, Gironde
Institut du Cancer de Montpellier ( Site 1002), Montpellier, Herault
CHRU de Tours - Hopital Bretonneau ( Site 1018), Tours, Indre-et-Loire
Institut De Cancerologie De L Ouest ( Site 1003), Saint Herblain, Loire-Atlantique
Hôpital Claude Huriez ( Site 1030), Lille, Nord
Hopital Henri Mondor ( Site 1007), Creteil, Val-de-Marne
Hopital Saint Louis ( Site 1029), Paris, Not set
Centro Regional de Sub Especialidades Medicas SA ( Site 0604), Guatemala, Quetzaltenango
MEDI-K ( Site 0601), Guatemala, Not set
Oncomedica ( Site 0602), Guatemala, Not set
Soluciones Gastrointestinales S.A. ( Site 0607), Guatemala, Not set
Queen Mary Hospital ( Site 4001), Hong Kong, Not set
Queen Elizabeth Hospital. ( Site 4004), Kowloon, Not set
Pecsi Tudomanyegyetem AOK ( Site 1204), Pecs, Baranya
Petz Aladar Egyetemi Oktato Korhaz ( Site 1210), Gyor, Gyor-Moson-Sopron
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1203), Szolnok, Jasz-Nagykun-Szolnok
Orszagos Onkologiai Intezet ( Site 1207), Budapest, Not set
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 1313), Meldola, Emilia-Romagna
A.O.U. Santa Maria della Misericordia di Udine ( Site 1302), Udine, Friuli-Venezia Giulia
Humanitas Research Hospital ( Site 1309), Rozzano, Lombardia
Azienda Ospedaliera Universitaria Pisana ( Site 1312), Pisa, Toscana
Istituto Oncologico Veneto IRCCS-Oncologia Medica 1 ( Site 1311), Padova, Veneto
Azienda Ospedaliera Mater Domini-Translational Oncology Unit ( Site 1314), Catanzaro, Not set
Azienda Ospedaliero Universitaria Careggi ( Site 1301), Firenze, Not set
IRCCS Ospedale San Raffaele di Milano ( Site 1304), Milano, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1306), Milano, Not set
A.O. Universitaria di Modena ( Site 1307), Modena, Not set
A.O.U. Universita degli Studi della Campania-Luigi Vanvitelli ( Site 1305), Napoli, Not set
Universita Cattolica del Sacro Cuore - Policlinico Gemelli ( Site 1310), Roma, Not set
Aichi Cancer Center Hospital ( Site 9006), Nagoya, Aichi
Chiba Cancer Center ( Site 9023), Chiba-shi, Chiba
National Cancer Center Hospital East ( Site 9002), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 9019), Matsuyama, Ehime
Hyogo Cancer Center ( Site 9014), Akashi, Hyogo
Ibaraki Prefectural Central Hospital ( Site 9007), Kasama, Ibaraki
Kagawa University Hospital ( Site 9015), Kita-gun, Kagawa
Kanagawa Cancer Center ( Site 9004), Yokohama, Kanagawa
Tohoku University Hospital ( Site 9013), Sendai-shi, Miyagi
Niigata Cancer Center Hospital ( Site 9022), Niigata-shi, Niigata
Kindai University Hospital ( Site 9017), Sayama, Osaka
Osaka University Hospital ( Site 9021), Suita, Osaka
Osaka Medical and Pharmaceutical University Hospital ( Site 9008), Takatsuki, Osaka
Saitama Prefectural Cancer Center ( Site 9003), Kitaadachi-gun, Saitama
Shizuoka Cancer Center ( Site 9016), Nagaizumi, Shizuoka
Tokyo Metropolitan Komagome Hospital ( Site 9028), Bunkyo ku, Tokyo
Toranomon Hospital ( Site 9026), Minato-ku, Tokyo
Showa University Hospital ( Site 9025), Shinagawa, Tokyo
National Hospital Organization Kyushu Cancer Center ( Site 9010), Fukuoka, Not set
University Hospital,Kyoto Prefectural University of Medicine ( Site 9027), Kyoto, Not set
Kyoto University Hospital ( Site 9011), Kyoto, Not set
Okayama University Hospital ( Site 9024), Okayama, Not set
Osaka International Cancer Institute ( Site 9009), Osaka, Not set
Osaka General Medical Center ( Site 9018), Osaka, Not set
National Cancer Center Hospital ( Site 9001), Tokyo, Not set
The Cancer Institute Hospital of JFCR ( Site 9005), Tokyo, Not set
Keio University Hospital ( Site 9020), Tokyo, Not set
Seoul National University Bundang Hospital ( Site 5006), Seongnam-si, Kyonggi-do
Asan Medical Center ( Site 5002), Songpagu, Seoul
Severance Hospital ( Site 5003), Seoul, Not set
Samsung Medical Center ( Site 5005), Seoul, Not set
Korea University Guro Hospital ( Site 5001), Seoul, Not set
University Malaya Medical Centre ( Site 9101), Lembah Pantai, Kuala Lumpur
Sarawak General Hospital-Radiotherapy Unit ( Site 9100), Kuching, Sarawak
Hospital Kuala Lumpur ( Site 9104), Kuala Lumpur, Not set
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2201), Bucharest, Bucuresti
Cardiomed SRL Cluj-Napoca-Medical Oncology ( Site 2207), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL ( Site 2202), Comuna Floresti, Cluj
Ovidius Clinical Hospital OCH-Oncology and Hematology ( Site 2203), Ovidiu, Constanta
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2204), Craiova, Dolj
Policlinica Oncomed SRL ( Site 2206), Timisoara, Timis
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1507), Ufa, Baskortostan, Respublika
GBUZ LOKB ( Site 1502), Saint-Petersburg, Leningradskaya Oblast
FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 1510), Moscow, Moskva
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1503), Saint Petersburg, Sankt-Peterburg
Academician I.P. Pavlov First St. Petersburg State Medical University ( Site 1519), Saint-Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 150, Kazan, Tatarstan, Respublika
SAIH of Tyumen reg "Multifield clinical medical center "Medical city" ( Site 1520), Tyumen, Tyumenskaya Oblast
National Cancer Centre Singapore ( Site 9201), Singapore, Central Singapore
Wits Clinical Research ( Site 9502), Johannesburg, Gauteng
The Oncology Centre ( Site 9505), Durban, Kwazulu-Natal
Hospital Universitario General de Asturias ( Site 1601), Oviedo, Asturias
Hospital Universitario Marques de Valdecilla ( Site 1602), Santander, Cantabria
Complexo Hospitalario Universitario de Ourense-MEDICAL ONCOLOGY ( Site 1609), Ourense, Orense
Hospital General Universitari Vall d Hebron ( Site 1607), Barcelona, Not set
Hospital General Universitario Gregorio Maranon ( Site 1604), Madrid, Not set
Hospital Virgen del Rocio ( Site 1606), Sevilla, Not set
Chi Mei Hospital - Liouying Branch-Clinical Trial Center ( Site 6007), Tainan City, Tainan
Chang Gung Med Foundation. Kaohsiung Branch ( Site 6005), Kaohsiung, Not set
China Medical University Hospital ( Site 6003), Taichung, Not set
National Cheng Kung University Hospital ( Site 6004), Tainan, Not set
National Taiwan University Hospital ( Site 6001), Taipei, Not set
Taipei Veterans General Hospital ( Site 6006), Taipei, Not set
Faculty of Medicine Siriraj Hospital ( Site 7002), Bangkok, Krung Thep Maha Nakhon
Songklanagarind hospital ( Site 7001), HatYai, Songkhla
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 1714), Adana, Not set
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1701), Ankara, Not set
Memorial Ankara Hastanesi ( Site 1702), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1715), Ankara, Not set
Atatürk Üniversitesi-onkoloji ( Site 1712), Erzurum, Not set
Acibadem Universitesi Atakent Hastanesi-Medical Oncology ( Site 1716), Istanbul, Not set
Istanbul Okmeydanı Egitim ve Arastirma Hastanesi ( Site 1711), Istanbul, Not set
Medeniyet Universitesi Tip Fakultesi ( Site 1703), İstanbul, Not set
Chernihiv Medical Center of Modern Oncology ( Site 1811), Chernihiv, Chernihivska Oblast
Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 1819), Chernivtsi, Chernivetska Oblast
MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council ( Site 1804), Kryviy Rih, Dnipropetrovska Oblast
Kharkiv Regional Clinical Oncology Center ( Site 1812), Kharkiv, Kharkivska Oblast
Institute of General and Emergency Surgery n.a Zaitsev NAMS of Ukraine ( Site 1813), Kharkiv, Kharkivska Oblast
Communal nonprofit enterprise "Kherson Regional Oncology Dispensary" of Kherson Regional Council (, Antonivka Village, Khersonska Oblast
SNPE National Cancer Institute ( Site 1806), Kyiv, Kyivska Oblast
Rivne Regional Clinical Hospital ( Site 1817), Rivne, Rivnenska Oblast
Podillya Regional Center of Oncology ( Site 1809), Vinnytsia, Vinnytska Oblast
Volyn Regional Oncological Dispensary ( Site 1816), Lutsk, Volynska Oblast
Shalimov Institute of Surgery and Transplantation ( Site 1818), Kyiv, Not set
Cambridge University Hospitals NHSFT ( Site 1908), Cambridge, Cambridgeshire
Ninewells Hospital and Medical School ( Site 1907), Dundee, Dundee City
Nottingham University Hospital NHS Trust ( Site 1910), Nottingham, England
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1915), London, London, City Of
University College London Hospitals NHS Foundation Trust ( Site 1901), London, London, City Of
Royal Marsden NHS Foundation Trust ( Site 1905), London, London, City Of
Royal Marsden NHS Trust. ( Site 1906), Sutton, London, City Of
Western General Hospital ( Site 1912), Edinburgh, Midlothian
The Christie NHS Foundation Trust ( Site 1909), Manchester, Not set
Conditions: Metastatic Esophageal Squamous Cell Carcinoma
Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer
Recruiting
The primary objective of this study is to compare the effect of zimberelimab (ZIM) and domvanalimab (DOM) in combination with chemotherapy relative to pembrolizumab (PEMBRO) in combination with chemotherapy on overall survival (OS) in patients with untreated metastatic non-small cell lung cancer with no actionable genomic alteration.
The primary objective of this study is to compare the effect of zimberelimab (ZIM) and domvanalimab (DOM) in combination with chemotherapy relative to pembrolizumab (PEMBRO) in combination with chemotherapy on overall survival (OS) in patients with untreated metastatic non-small cell lung cancer with no actionable genomic alteration. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Palo Verde Hematology Oncology Ltd, Glendale, Arizona +226 locations
Palo Verde Hematology Oncology Ltd, Glendale, Arizona
California Cancer Associates for Research and Excellence, San Marcos, California
Texas Oncology, Santa Barbara, California
Innovative Clinical Research Institute, Whittier, California
Eastern CT Hematology and Oncology Associates, Norwich, Connecticut
George Washington Medical Faculty Associates, Washington, District of Columbia
Lake City Cancer Care, Lake City, Florida
Florida Cancer Specialists, Sarasota, Florida
Moffitt Cancer Center, Tampa, Florida
Peachtree Hematology Oncology Consultants, Atlanta, Georgia
Illinois Cancer Care, Peoria, Illinois
Messino Cancer Centers, Asheville, North Carolina
Oncology Hematology Care, Inc., Cincinnati, Ohio
Hematology & Oncology Associates, Eugene, Oregon
AHN Allegheny General Hospital, Pittsburgh, Pennsylvania
Arlington Cancer Center, Arlington, Texas
Texas Oncology - Austin, Austin, Texas
Texas Oncology, Dallas, Texas
Texas Oncology- Denison, Sherman, Texas
US Oncology Investigational Products Center (IPC), Arlington, Virginia
Oncology and Hematology Associates of Southwest Virginia, Inc, Blacksburg, Virginia
Northwest Cancer Specialists, PC, Vancouver, Washington
Investigaciones CORI S.R.L., Capital, Not set
Centro Médico Privado Centro de Especialidades Médicas Ambulatorias e Investigación Clínica, Cardoba, Not set
Centro Medico Barrio Parque, Ciudad Autanoma Buenos Aires, Not set
Sanatorio Allende, Cordoba, Not set
Sanatorio Britanico de Rosario, Rosario, Not set
Sanatorio Parque de Rosario, Rosario, Not set
Hospital Provincial del Centenario, Rosario, Not set
Instituto Medico de la Fundacion Estudios Clinicos, Rosario, Not set
CAIPO - Centro para la Atención Integral del Paciente Oncológico, San Miguel de Tucumán, Not set
Clínica Viedma, Viedma, Not set
Klinikum Klagenfurt am Woerthersee, Klagenfurt Am Woerthersee, Not set
Ordensklinikum Linz GmbH, Elisabethinen, Linz, Not set
Klinikum Wels-Grieskirchen, Wels, Not set
Krankenhaus Nord - Klinik Floridsdorf, Wien, Not set
Algemeen Ziekenhuis Sint-Lucas, Aalst, Not set
Grand Hopital de Charleroi asbl (GHdC), Charleroi, Not set
AZ Sint-Maarten, Mechelen, Not set
CHU UCL Namur / Site Sainte Elisabeth, Namur, Not set
Cenantron Centro Avançado de Tratamento Oncologico Ltda, Belo Horizonte, Not set
Hospital Evangelico de Cachoeiro de Itapemirim, Cachoeiro De Itapemirim, Not set
Fundacao Universidade De Caxias Do Sul - FUCS/RS, Caxias Do Sul, Not set
Instituto do Câncer do Ceará - ICC, Fortaleza, Not set
Oncosite - Centro de Pesquisa Clinica em Oncologia LTDA, Ijui, Not set
Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set
Hospital São Lucas da PUCRS, Porto Alegre, Not set
Hospital Ana Nery Santa Cruz do Sul, Santa Cruz Do Sul, Not set
Centro Des Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho, Sao Paolo, Not set
Instituto Brasiliero de Controle do Cancer IBCC, Sao Paulo, Not set
Centre Integre de sante et de services sociaux de la Monteregie Centre, Greenfield Park, Not set
Moncton Hospital, Moncton, Not set
CISSS des Laurentides, Quebec, Not set
Centre de santé et services sociaux de Rimouski-Neigette, Rimouski, Not set
BC Cancer - Victoria, Victoria, Not set
Clinica Alemana de Santiago, Las Condes, Not set
Orlandioncologia, Providencia, Not set
Oncovida- Santiago, Providencia, Not set
Clinica Puerto Montt, Puerto Montt, Not set
Biocinetic, Santiago, Not set
James Lind Centro de Investigacion del Cancer, Temuco, Not set
Oncocentro APYS, Vina del Mar, Not set
West China Hospital Sichuan University, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Deyang People's Hospital, Deyang, Not set
Fujian Cancer Hospital, Fuzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Guangzhou First People's Hospital, Guangzhou, Not set
Nanfang Hospital, Southern Medical University, Guangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Anhui Chest Hospital, Hefei, Not set
The Second Affiliated Hospital of Nanchang University, Jiangxi, Not set
Shandong Cancer Hospital, Jinan, Not set
Jiangxi Chest Hospital, Nanchang, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Guangxi Medical University Cancer Hospital, Nanning, Not set
Shanghai Chest Hospital, Shanghai, Not set
Shanghai East Hospital, Shanghai, Not set
Shanghai Pulmonary Hospital, Shanghai, Not set
Cancer Hospital of Shantou University Medical College, Shantou, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Not set
Tongji Hospital Tongji Medical College of Hust, Wuhan, Not set
The First Affiliated Hospital of Xian Jiaotong University, Xi'an, Not set
The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Ambroise-Pare Hospital, Assistance Publique - Hopitaux de Paris, Boulogne-Billancourt, Not set
CHU de Caen, Caen, Not set
Clinique Victor Hugo, Centre de Cancerologie de la Sarthe, Le Mans, Not set
Hopital Nord, Marseille, Not set
Institut de Cancer de Montpellier (ICM) - Val d'Aurelle, Montpellier, Not set
Centre Antoine Lacassagne, Nice, Not set
Institut de cancerologie de l'ouest (ICO), Saint-Herblain, Not set
Hopital d'Instruction des Armees (HIA) Begin, Saint-Mandé, Not set
Centre Hospitalier de Saint-Quentin, Saint-Quentin, Not set
Institut de Cancerologie Strasbourg Europe (ICANS), Strasbourg, Not set
Hôpital Foch, Suresnes, Not set
CHI de Toulon la Seyne-sur-Mer Hopital Sainte Musse, Toulon cedex, Not set
Augusta-Kranken-Anstalt gGmbh Klinik für Hämatologie Onkologie und Palliativmedizin, Bochum, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
Universitatsklinikum Essen / Westdeutsches Tumorzentrum, Innere Klinik (Tumorforschung), Essen, Not set
Universitätsklinikum Freiburg, Klinik für Innere Medizin I Hämatologie, Onkologie und Stammzelltransplantation, Freiburg, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Krankenhaus Martha-Maria Halle Dölau, Halle, Not set
Asklepios Kliniken Hamburg, Hamburg, Not set
Katholisches Marienkrankenhaus gGmbH, Hamburg, Not set
Lungenklinik Hemer, Zentrum fur Pneumologie and Thoraxchirurgie, Hemer, Not set
Vincentius-Diakonissen-Kliniken gAG, St. Vincentius-Kliniken, Medizinische Klinik 2, Karlsruhe, Not set
Klinikum Kassel, Kassel, Not set
Kliniken der Stadt Köln ggmbh, Krankenhaus Koln-Merheim/Lungenklinik, Köln, Not set
Universitatsklinikum Schleswig-Holstein, Lubeck, Not set
Johannes Wesling Klinikum Minden, Minden, Not set
Munchen Klinik Bogenhausen, Klinik fur Pneumologie und Pneumologische Onkologie, Munchen, Not set
Sana Klinikum Offenbach GmbH, Medizinische Klinik IV, Hämatologie und Internistische Onkologie, Offenbach, Not set
Queen Elizabeth Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Prince of Wales Hospital, New Territories, Not set
Soroka University Medical Center, Itzchak Rager Blvd., Beer Seva, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Oncology Institute, Galilee Medical Center, Route 89 Nahariya-Cabri, Nahariya, Not set
Rabin Medical Center, Petah Tiqva, Not set
Kaplan Medical Center, Rehovot, Not set
Tel-Aviv Sourasky Medical Center, Tel Aviv, Not set
Azienda Ospedaliera San Giuseppe Moscati, Avellino, Not set
IRCCS Fondazoine del Piemonte per l'Oncologia, Candiolo, Not set
Azienda Socio Sanitaria Territoriale di Cremona, Cremona, Not set
Ospedale Policlinico San Martino, Genova, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Ospedaliero Universitaria di Modena, Modena, Not set
AORN Cardarelli, Naples, Not set
Azienda Ospedaliera dei Colli, Napoli, Not set
IRCCS Policlinico S. Matteo, Dipartimento Oncologia Ematologia-Oncologia Medica, Pavia, Not set
Azienda Sanitaria Territoriale Pesaro e Urbino (AST), Pesaro, Not set
Ospedale Guglielmo da Saliceto AUSL di Piacenza, Piacenza, Not set
Centro di Riferimento Oncologico, Pordenone, Not set
Regina Elena Institute for Cancer Research, Rome, Not set
ASST Bergamo Ovest- ospedale di Treviglio, Treviglio, Not set
National Cancer Center Hospital East, Chiba, Not set
National Hospital Organization Shikoku Cancer Center, Ehime, Not set
Kyushu University Hospital, Fukuoka, Not set
Kurume University Hospital, Fukuoka, Not set
National Hospital Organization Himeji Medical Center, Hyogo, Not set
Hyogo Cancer Center, Hyogo, Not set
Kanazawa University Hospital, Ishikawa, Not set
Kanagawa Cancer Center, Kanagawa, Not set
Sendai Kousei Hospital, Miyagi, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Osaka Medical and Pharmaceutical University Hospital, Osaka, Not set
Kindai University Hospital, Osaka, Not set
National Hospital Organization Kinki Chuo Chest Medical Center, Osaka, Not set
Saitama Medical University, Saitama, Not set
SMG - SNU Boramae Medical Center, Dongjak-Gu, Not set
Samsung Medical Center, Gangnam-Gu, Not set
National Cancer Center, Goyang, Not set
Chungbuk National University Hospital, Heungdeok-Gu, Not set
Inha University Hospital, Incheon, Not set
Gachon University Gil Medical Center, Inchon, Not set
Kosin University Gospel Hospital, Seo-gu, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Ajou University Hospital, Suwon-si, Not set
The Catholic University of Korea, Saint Vincent's Hospital, Suwon, Not set
Health Pharma Professional Research S.A. de C.V., Mexico, Not set
Hospital Universitario Dr. Jose Eleuterio Gonzalez, Mitras Centro, Not set
Oaxaca Site Management Organization, Oaxaca, Not set
Centro de Investigacion Clinica de Oaxaca, Oaxaca, Not set
Clinical Medical Research SC., Orizaba Centro, Not set
Clinica Integral Internacional de Oncologia S de RL de CV, Puebla, Not set
FAICIC Clínical Research, Veracruz, Not set
Amphia Ziekenhuis, Breda, Not set
Ziekenhuis Gelderse Vallei, Ede, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Ziekenhuis St Jansdal, Harderwijk, Not set
TweeSteden Ziekenhuis, Tilburg, Not set
Hospital Prof. Doutor Fernando Fonseca, Amadora, Not set
Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Not set
Fundacao Champalimaud, Lisboa, Not set
Centro Hospitalar Universitário Lisboa Norte - Hospital Pulido Valente, Lisboa, Not set
Hospital Beatriz Angelo. Hospital de Loures., Lisbon, Not set
Centro Hospitalar Universitario Sao Joao, EPE, Porto, Not set
Unidade Local de Saude de Matosinhos EPE - Hospital Pedro Hispano SA, Senhora da Hora, Not set
Raffles Hospital, Singapore, Not set
Tang Tock Seng Hospital, Singapore, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i de Sant Pau, Barcelona, Not set
Hospital Universitari Dexeus (USP Institut Universitari Dexeus/Hospital Universitari Quiron Dexeus), Barcelona, Not set
Hospital Universitari Vall D'Hebron, Barcelona, Not set
Hospital Parc Tauli, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Doctor Josep Trueta, Girona, Not set
Hospital Universitario de Jaen, Jaen, Not set
Hospital Universitario de Canarias, Las Palmas de G.C., Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Clinica Universidad de Navarra, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Not set
Hospital Sant Joan de Reus, Reus, Not set
Hospital Regional Universitario de Malaga, Rincon de la Victoria, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen del Rocio, Seville, Not set
Instituto Valenciano De Oncologia (IVO), Valencia, Not set
Hospital Universitari i Politecnic La Fe, Valencia, Not set
Hospital Vithas Valencia 9 de Octubre, Valencia, Not set
Changhua Christian Hospital, Changhua City, Not set
E-DA Hospital, Kaohsiung City, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
Chang Gung Memorial Hospital Kaohsiung, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
Chi Mei Hospital, Liouying, Tainan, Not set
National Taiwan University Hospital, Taipei City, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital Linkou Branch of the Chang Gung Medical Foundation, Taoyuan City, Not set
Ankara Bilkent Sehir Hastanesi, Ankara, Not set
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi, Ankara, Not set
Trakya University Faculty of Medicine, Edirne, Not set
Istanbul University Cerrahpasa Medical Faculty Hospital, Fatih, Not set
Goztepe Prof. Dr. Suleyman Yalcın Sehir Hastanesi, Istanbul, Not set
Medipol Mega University Hospital, Istanbul, Not set
Acibadem Mehmet Ali Aydinlar Universitesi Atakent Hastanesi, Kaakaekmece, Not set
Turgut Ozal Medical Faculty, Malatya, Not set
Colchester General Hospital, Colchester, Not set
St Bartholomew's Hospital, Barts Health NHS Trust, London, Not set
The Christie NHS Foundation Trust, Department of Medical Oncology, Manchester, Not set
University Hospital Southampton Nhs Foundation Trust, Southampton, Not set
Conditions: Non-small Cell Lung Cancer
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Recruiting
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR).
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060), Little Rock, Arkansas +223 locations
UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060), Little Rock, Arkansas
Highlands Oncology Group-Research Department ( Site 0062), Springdale, Arkansas
Beverly Hills Cancer Center ( Site 0070), Beverly Hills, California
The Angeles Clinic and Research Institute ( Site 0040), Los Angeles, California
The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate ( Site 0079), Los Angeles, California
San Francisco Oncology Associates ( Site 0066), San Francisco, California
Stamford Hospital ( Site 0083), Stamford, Connecticut
Mount Sinai Cancer Center ( Site 0038), Miami Beach, Florida
Mid Florida Hematology and Oncology Center ( Site 0018), Orange City, Florida
Emory University School of Medicine-Phase I ( Site 0056), Atlanta, Georgia
Northside Hospital ( Site 0055), Atlanta, Georgia
Centricity Research Columbus Cancer Center ( Site 0005), Columbus, Georgia
Southeastern Regional Medical Center ( Site 0065), Newnan, Georgia
Lewis Cancer and Research Pavilion ( Site 0063), Savannah, Georgia
Archbold Cancer Center ( Site 0071), Thomasville, Georgia
Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0017), Elmhurst, Illinois
Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0078), Naperville, Illinois
Parkview Research Center at Parkview Regional Medical Center ( Site 0089), Fort Wayne, Indiana
Indiana University Health Arnett Cancer Center ( Site 0076), Lafayette, Indiana
Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0061), Edgewood, Kentucky
Our Lady of the Lake Physician Group-Medical Oncology ( Site 0080), Baton Rouge, Louisiana
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0027), Minneapolis, Minnesota
Mercy Research - David C. Pratt Cancer Center ( Site 0006), Saint Louis, Missouri
Renown Regional Medical Center-Renown Health Medical Oncology ( Site 0037), Reno, Nevada
Atlantic Health Morristown Medical Center ( Site 0077), Morristown, New Jersey
Cayuga Medical Center ( Site 0086), Ithaca, New York
Stony Brook University-Cancer Center ( Site 0054), Stony Brook, New York
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0057), Fargo, North Dakota
Oregon Health and Science University ( Site 0052), Portland, Oregon
Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0068), Lancaster, Pennsylvania
Medical University of South Carolina-Hollings Cancer Center ( Site 0045), Charleston, South Carolina
Sanford Cancer Center ( Site 0053), Sioux Falls, South Dakota
Avera Cancer Institute- Research ( Site 0090), Sioux Falls, South Dakota
University of Tennessee Medical Center Knoxville ( Site 0082), Knoxville, Tennessee
Millennium Research & Clinical Development ( Site 0039), Houston, Texas
Huntsman Cancer Institute ( Site 0042), Salt Lake City, Utah
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0213), Ciudad Autonoma de Buenos Aires, Buenos Aires
Hospital Británico de Buenos Aires-Oncology ( Site 0207), Ciudad autónoma de Buenos Aires, Buenos Aires
Sanatorio Británico-Clinical Oncology Department ( Site 0206), Rosario, Santa Fe
Sanatorio Parque ( Site 0205), Rosario, Santa Fe
Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L ( Site 0217), San Miguel de Tucuman, Tucuman
Hospital Aleman-Oncology ( Site 0202), Buenos Aires, Not set
Hospital Privado Universitario de Córdoba-Hematology and Oncology ( Site 0204), Cordoba, Not set
Westmead Hospital ( Site 0701), Westmead, New South Wales
The Prince Charles Hospital ( Site 0700), Brisbane, Queensland
Fiona Stanley Hospital-Medical Oncology ( Site 0705), Murdoch, Western Australia
Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 1402), Linz, Oberosterreich
Medizinische Universitaet Innsbruck-Department for Internal Medicine V ( Site 1403), Innsbruck, Tirol
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 1400), Wien, Not set
Antwerp University Hospital-Thoracic Oncology ( Site 1503), Edegem, Antwerpen
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi ( Site 1502), Yvoir, Namur
VITAZ ( Site 1500), Sint-Niklaas, Oost-Vlaanderen
Liga Norte Riograndense Contra o Câncer ( Site 0301), Natal., Rio Grande Do Norte
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0303), Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceição ( Site 0302), Porto Alegre, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 0319), Santa Cruz do Sul, Rio Grande Do Sul
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0304), Barretos, Sao Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0313), São José do Rio Preto, Sao Paulo
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0100), Greenfield Park, Quebec
St. Marys Hospital Center ( Site 0107), Montreal, Quebec
Centre Hospitalier de l'Université de Montréal ( Site 0104), Montréal, Quebec
FALP-UIDO ( Site 0401), Providencia, Region M. De Santiago
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 0404), Santiago., Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0400), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0410), Viña del Mar, Valparaiso
Beijing Cancer hospital-Thoracic Surgery department I ( Site 1301), Beijing, Beijing
Beijing Peking Union Medical College Hospital-Thoracic surgery department ( Site 1302), Beijing, Beijing
Peking University People's Hospital. ( Site 1300), Beijing, Beijing
Fujian Cancer Hospital-oncology department ( Site 1314), Fuzhou, Fujian
The First Affiliated Hospital of Guangzhou Medical University-thoracic surgery department ( Site 1320), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital-Thoracic surgery department ( Site 1313), Guangzhou, Guangdong
Henan Cancer Hospital-henan cancer hospital ( Site 1316), Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology-Thoracic Surgery ( Site 1306), Wuhan, Hubei
Hubei Cancer Hospital ( Site 1308), Wuhan, Hubei
Xiangya Hospital Central South University-Thoracic surgery ( Site 1311), Changsha, Hunan
Hunan Cancer Hospital ( Site 1312), Changsha, Hunan
Nanjing First Hospital ( Site 1310), Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University-Thoracic Surgery Department ( Site 1318), Suzhou, Jiangsu
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 1330), Nanchang, Jiangxi
The First Hospital of Jilin University ( Site 1324), Changchun, Jilin
The Second Affiliated Hospital of Air Force Medical University ( Site 1332), Xian, Shaanxi
Shandong Cancer Hospital ( Site 1321), Jinan, Shandong
Zhongshan Hospital Fudan University ( Site 1325), Shangai, Shanghai
Shanghai Pulmonary Hospital-Thoracic Surgery department ( Site 1304), Shanghai, Shanghai
Sichuan Cancer hospital. ( Site 1327), Chengdu, Sichuan
The Second People's Hospital of Neijiang ( Site 1322), Neijiang, Sichuan
Yunnan Province Cancer Hospital ( Site 1315), Kunming, Yunnan
The first Affiliated Hospital, Zhejiang University School of-Thoracic Cardiovascular Surgery Ward ( Site 1303), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 1309), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 1328), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 1329), Linhai, Zhejiang
Ningbo No. 2 Hospital ( Site 1305), Ningbo, Zhejiang
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 1600), Brno, Brno-mesto
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 1601), Ostrava, Ostrava Mesto
CHRU de Brest ( Site 1804), Brest, Finistere
CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 1801), Toulouse, Haute-Garonne
CHU Charles Nicolle ( Site 1803), Rouen, Haute-Normandie
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1805), Limoges, Haute-Vienne
Groupe hospitalier Paris saint Joseph. ( Site 1807), Paris, Ile-de-France
Clinique Teissier Groupe ( Site 1811), Valenciennes, Nord
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1810), Clermont-Ferrand, Puy-de-Dome
Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1809), Bron, Rhone
HIA Sainte Anne ( Site 1800), Toulon, Var
Hôpital Tenon ( Site 1802), Paris, Not set
Klinikum Esslingen-Klinik für Kardiologie und Pneumologie ( Site 1914), Esslingen, Baden-Wurttemberg
Katholisches Klinikum Koblenz ( Site 1911), Koblenz, Rheinland-Pfalz
Krankenhaus Martha-Maria Halle-Dölau-Klinik für Innere Medizin II ( Site 1908), Halle, Sachsen-Anhalt
Universitätsklinikum Leipzig ( Site 1915), Leipzig, Sachsen
SRH Wald-Klinikum Gera-Lungenkrebszentrum ( Site 1900), Gera, Thuringen
Vivantes Hospital Spandau-Klinik für Innere Medizin, Hämatologie, Onkologie und Gastroenterologie- ( Site 1912), Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf ( Site 1916), Berlin, Not set
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 2006), Patras, Achaia
251 Hellenic Air Force General Hospital ( Site 2003), Athens, Attiki
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 2000), Athens, Attiki
Athens Medical Center ( Site 2005), Athens, Attiki
Metaxa Cancer Hospital of Piraeus ( Site 2002), Piraeus, Attiki
University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 2001), Heraklion, Irakleio
University General Hospital of Larissa-Oncology Clinic ( Site 2004), Larissa, Thessalia
European Interbalkan Medical Center ( Site 2007), Thessaloniki, Not set
Queen Mary Hospital ( Site 3400), Hksar, Not set
Hong Kong United Oncology Centre ( Site 3403), Kowloon, Not set
Queen Elizabeth Hospital ( Site 3402), Yau Ma Tei, Not set
Rambam Health Care Campus-Oncology Division ( Site 2203), Haifa, Not set
Shaare Zedek Medical Center ( Site 2206), Jerusalem, Not set
Rabin Medical Center ( Site 2204), Petah Tikva, Not set
Sheba Medical Center ( Site 2200), Ramat Gan, Not set
Humanitas Istituto Clinico Catanese ( Site 2315), Misterbianco, Catania
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 2302), Meldola, Emilia-Romagna
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 2300), Milan, Lombardia
Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 2301), Monza, Lombardia
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 2309), Rome, Roma
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 2307), Firenze, Toscana
Humanitas Gavazzeni-ONCOLOGY ( Site 2310), Bergamo, Not set
Ospedale San Martino ( Site 2313), Genova, Not set
Ospedale San Raffaele-Oncologia Medica ( Site 2311), Milano, Not set
Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 2312), Parma, Not set
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 2303), Pavia, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 2306), Roma, Not set
APSS- Presidio Ospedaliero S. Chiara ( Site 2304), Trento, Not set
National Hospital Organization Shikoku Cancer Center ( Site 1216), Matsuyama, Ehime
Hospital of the University of Occupational and Environmental Health, Japan ( Site 1217), Kitakyushu, Fukuoka
Kobe City Medical Center General Hospital ( Site 1213), Kobe, Hyogo
St. Marianna University Hospital ( Site 1207), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 1206), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 1211), Hirakata, Osaka
Kindai University Hospital ( Site 1212), Osakasayama, Osaka
Saitama Prefectural Cancer Center ( Site 1201), Kitaadachi-gun, Saitama
Juntendo University Hospital ( Site 1204), Bunkyo-ku, Tokyo
Tokyo Medical University Hospital ( Site 1203), Shinjuku, Tokyo
National Hospital Organization Kyushu Cancer Center ( Site 1218), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 1200), Fukushima, Not set
Hiroshima University Hospital ( Site 1215), Hiroshima, Not set
Niigata Cancer Center Hospital ( Site 1208), Niigata, Not set
Okayama University Hospital ( Site 1214), Okayama, Not set
Osaka International Cancer Institute ( Site 1210), Osaka, Not set
Nippon Medical School Hospital ( Site 1205), Tokyo, Not set
Chungbuk National University Hospital-Internal medicine ( Site 1000), Cheongju-si, Chungbuk
National Cancer Center-Lung Cancer Center ( Site 1002), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital-Medical Oncology ( Site 1003), Seongnam, Kyonggi-do
The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 1001), Suwon-si, Kyonggi-do
Keimyung University Dongsan Hospital CRC room 1 ( Site 1006), Daegu, Taegu-Kwangyokshi
Asan Medical Center-Lung Cancer Center ( Site 1005), Seoul, Not set
Samsung Medical Center-Division of Hematology/Oncology ( Site 1004), Seoul, Not set
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0506), Guadalajara, Jalisco
Centro de Investigacion Clinica de Oaxaca ( Site 0509), Oaxaca de Juarez, Oaxaca
Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 0504), Chihuahua, Not set
Mediadvance Clinical ( Site 0502), Chihuahua, Not set
Oaxaca Site Management Organization S.C. ( Site 0507), Oaxaca, Not set
Amphia Ziekenhuis, locatie Breda Molengracht-long oncologie ( Site 3453), Breda, Noord-Brabant
Isala, locatie Zwolle-Poli Longziekten ( Site 3454), Zwolle, Overijssel
Meander Medisch Centrum-Researchbureau Longgeneeskunde ( Site 3458), Amersfoort, Utrecht
Erasmus Medisch Centrum ( Site 3452), Rotterdam, Zuid-Holland
University Medical Center Groningen ( Site 3459), Groningen, Not set
Sint Antonius Ziekenhuis ( Site 3455), Utrecht, Not set
Auckland City Hospital ( Site 0800), Auckland, Not set
Akershus Universitetssykehus ( Site 2501), Lørenskog, Akershus
Drammen Sykehus, Vestre Viken HF ( Site 2502), Drammen, Buskerud
Sykehuset Innlandet HF Gjøvik ( Site 2503), Gjøvik, Oppland
Oslo universitetssykehus HF. Radiumhospitalet ( Site 2504), Oslo, Not set
IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 0604), Lima, Not set
Oncosalud ( Site 0602), Lima, Not set
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 0600), Lima, Not set
Instituto Neuro Cardiovascular de las Americas ( Site 0607), Lima, Not set
Hospital Nacional Edgardo Rebagliati Martins-medical oncology ( Site 0603), Lima, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2600), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2601), Przemysl, Podkarpackie
Bialostockie Centrum Onkologii ( Site 2604), Bialystok, Podlaskie
Uniwersyteckie Centrum Kliniczne ( Site 2610), Gdansk, Pomorskie
Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 2613), Prabuty, Pomorskie
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie-Oddzial Onkologii z Pododdzialem Chemioterapii ( Site 2606), Olsztyn, Warminsko-mazurskie
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 2602), Poznan, Wielkopolskie
UNIDADE LOCAL DE SAUDE DE MATOSINHOS-Serviço de Oncologia ( Site 2705), Matosinhos, Porto
Instituto Portugês de Oncologia de Coimbra Francisco Gentil-Oncologia Médica ( Site 2704), Coimbra, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2702), Porto, Not set
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L.. ( Site 2803), Bucharest, Bucuresti
Spitalul Universitar de Urgență Elias ( Site 2804), București, Bucuresti
Cardiomed SRL Cluj-Napoca-Medical Oncology ( Site 2801), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2802), Florești, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2805), Craiova, Dolj
Spitalul Clinic Municipal De Urgenta Timisoara ( Site 2806), Timişoara, Timis
SC ONCO CARD SRL ( Site 2808), Brasov, Not set
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2901), L Hospitalet, Barcelona
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2905), Santiago de Compostela, La Coruna
Hospital Insular de Gran Canaria-Oncology ( Site 2903), Las Palmas de Gran Canaria, Las Palmas
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2902), Pozuelo de Alarcon, Madrid
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2900), Barcelona, Not set
Hospital Clinico San Carlos-Oncology Department ( Site 2904), Madrid, Not set
Kantonsspital Graubünden-Medizin ( Site 3006), Chur, Grisons
Kantonsspital Münsterlingen - Spital Thurgau AG ( Site 3005), Munsterlingen, Thurgau
CHUV (centre hospitalier universitaire vaudois) ( Site 3003), Lausanne, Vaud
HFR Fribourg - Hôpital Cantonal ( Site 3004), Fribourg, Not set
National Taiwan University Cancer Center (NTUCC) ( Site 1105), Taipei City, Taipei
Tri-Service General Hospital ( Site 1100), Taipei City, Taipei
Taoyuan General Hospital ( Site 1106), Taoyuan City, Taoyuan
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 1103), Kaohsiung, Not set
Taichung Veterans General Hospital-Chest ( Site 1101), Taichung, Not set
National Cheng Kung University Hospital-Clinical Trial Center ( Site 1102), Tainan, Not set
National Taiwan University Hospital-Oncology ( Site 1104), Taipei, Not set
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 3106), Adana, Not set
Gulhane Egitim Arastirma Hastanesi-Onkoloji ( Site 3104), Ankara, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 3101), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 3110), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 3103), Ankara, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3107), Istanbul, Not set
Conditions: Non Small Cell Lung Cancer
AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
Recruiting
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted thoracic tumors. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted thoracic... Read More
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted thoracic tumors. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted thoracic tumors. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/20/2025
Locations: Comprehensive Blood and Cancer Center, Bakersfield, California +78 locations
Comprehensive Blood and Cancer Center, Bakersfield, California
City of Hope National Medical Center, Duarte, California
Translational Research in Oncology US Inc, Trio Central Pharmacy, Los Angeles, California
University of California Irvine, Orange, California
University of California Los Angeles, Santa Monica, California
Rocky Mountain Cancer Centers, Denver, Colorado
Eastern Connecticut Hematology and Oncology Associates, Norwich, Connecticut
HealthPartners Institute, Saint Paul, Minnesota
Saint Lukes Hospital of Kansas City, Kansas City, Missouri
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Roswell Park Cancer Institute, Buffalo, New York
New York University Grossman School of Medicine, New York, New York
Perlmutter Cancer Center at New York University Langone Hospital----Long Island, New York, New York
Upstate University Hospital, Syracuse, New York
Hightower Clinical, Oklahoma City, Oklahoma
Fox Chase Cancer Center, Philadelphia, Pennsylvania
University of Tennessee Medical Center Knoxville, Knoxville, Tennessee
United States Oncology Regulatory Affairs Corporate Office, Nashville, Tennessee
Texas Oncology - Dallas Fort Worth, Dallas, Texas
US Oncology Research Investigational Products Center, Dallas, Texas
Oncology Consultants Cancer Center, Houston, Texas
Texas Oncology Northeast Texas, Tyler, Texas
Virginia Cancer Specialists PC, Fairfax, Virginia
Northwest Medical Specialties, PLLC, Tacoma, Washington
Instituto Argentino de Diagnóstico y Tratamiento, Ciudad Automona De Buenos Aires, Buenos Aires
Cemic, Ciudad Autonoma Buenos Aires, Not set
Orange Health Service, Orange, New South Wales
The Queen Elizabeth Hospital, Woodville South, South Australia
Medizinische Universitaet Graz, Graz, Not set
Medizinische Universitaet Innsbruck, Innsbruck, Not set
Centre Hospitalier Universitaire de Liege - Sart Tilman, Liege, Not set
Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, Rio Grande Do Sul
Beneficencia Portuguesa de Sao Paulo - Bp, Sao Paulo, São Paulo
Fund Fac Reg Med Sao Jose Rio Preto, São José do Rio Preto, São Paulo
Instituto Cancer Sao Paulo Icesp, São Paulo, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
Mengchao Hepatobiliary hospital of Fujian Medical University, Fuzhou, Fujian
Guangdong Provincial Peoples Hospital, Guangzhou, Guangdong
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei
Jilin Cancer Hospital, Changchun, Jilin
West China Hospital of Sichuan University, Chengdu, Sichuan
Beijing Cancer Hospital, Beijing, Not set
Institut Bergonie, Bordeaux, Not set
Hopital de la Timone, Marseille, Not set
Institut de Cancerologie de l Ouest Rene Gauducheau, Saint Herblain, Not set
Gustave Roussy, Villejuif, Not set
Universitaetsklinikum Essen, Essen, Not set
Thoraxklinik Heidelberg, Heidelberg, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
Alexandra Hospital, Athens, Not set
Saint Luke Hospital, Thessaloniki, Not set
General Hospital Of Thessaloniki Papageorgiou, Thessaloniki, Not set
Queen Mary Hospital, The University of Hong Kong, Hong Kong, Not set
Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Alessandria, Not set
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set
IRCCS Istituto Clinico Humanitas, Rozzano (MI), Not set
Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona, Not set
Aichi Cancer Center, Nagoya-shi, Aichi
National Cancer Center Hospital East, Kashiwa-shi, Chiba
Shizuoka Cancer Center, Sunto-gun, Shizuoka
Wakayama Medical University Hospital, Wakayama-shi, Wakayama
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Radboud Universitair Medisch Centrum, Nijmegen, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Narodowy Instytut Onkologii im Marii Slodowskiej Curie Panstwowy Instytut Badawczy, Gliwice, Not set
Futuremeds spolka z ograniczona odpowiedzialnoscia, Kraków, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
Centrum Medyczne Hope Clinic Sebastian Szklener, Lublin, Not set
Hospital Universitari Vall d Hebron, Barcelona, Cataluña
Hospital Clinic i Provincial de Barcelona, Barcelona, Cataluña
Hospital Universitario 12 de Octubre, Madrid, Not set
National Cheng Kung University Hospital, Tainan, Not set
Taipei Veterans General Hospital, Taipei, Not set
Adana Sehir Egitim ve Arastirma Hastanesi, Adana, Not set
Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara, Not set
Ankara Bilkent Sehir Hastanesi, Ankara, Not set
Conditions: Thoracic Tumors, Non-small Cell Lung Cancer
A Study Evaluating AMG 193 in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)
Recruiting
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or... Read More
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted gastrointestinal, biliary tract, or pancreatic cancers. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/19/2025
Locations: Comprehensive Blood and Cancer Center, Bakersfield, California +71 locations
Comprehensive Blood and Cancer Center, Bakersfield, California
City of Hope National Medical Center, Duarte, California
University of California San Diego Moores Cancer Center, La Jolla, California
Translational Research in Oncology US Inc, Trio Central Pharmacy, Los Angeles, California
University of California Los Angeles, Santa Monica, California
Rocky Mountain Cancer Centers, Aurora, Colorado
Hartford Hospital, Hartford, Connecticut
Yale University, New Haven, Connecticut
Norwalk Hospital, Norwalk, Connecticut
University of Chicago, Chicago, Illinois
Indiana University, Indianapolis, Indiana
Norton Cancer Institute, Louisville, Kentucky
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Washington University, Saint Louis, Missouri
University of Nebraska, Omaha, Nebraska
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Memorial Sloan Kettering Cancer Center, New York, New York
Duke University, Durham, North Carolina
Cleveland Clinic Foundation, Cleveland, Ohio
United States Oncology Regulatory Affairs Corporate Office, Nashville, Tennessee
Oncology Consultants Cancer Center, Houston, Texas
US Oncology Research Investigational Products Center, Irving, Texas
University of Virginia Cancer Center, Charlottesville, Virginia
Virginia Cancer Specialists PC, Fairfax, Virginia
Northwest Medical Specialties, PLLC, Tacoma, Washington
Northwest Cancer Specialists - Vancouver, Vancouver, Washington
Chris OBrien Lifehouse, Camperdown, New South Wales
GenesisCare -North Shore Oncology, St Leonards, New South Wales
The Queen Elizabeth Hospital, Woodville South, South Australia
Austin Health, Austin Hospital, Heidelberg, Victoria
Peter MacCallum Cancer Centre, Melbourne, Victoria
Epworth Healthcare, St Albans, Victoria
Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Bruxelles, Not set
Universitair Ziekenhuis Antwerpen, Edegem, Not set
Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Princess Margaret Cancer Centre, Toronto, Ontario
CHU de Quebec Hopital de l Enfant Jesus, Quebec, Not set
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei
Herlev og Gentofte Hospital, Herlev, Not set
Institut Bergonie, Bordeaux, Not set
Centre Georges Francois Leclerc, Dijon, Not set
Institut Paoli Calmettes, Marseille, Not set
Gustave Roussy, Villejuif, Not set
Universitaetsklinikum Essen, Essen, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
Alexandra Hospital, Athens, Not set
Saint Luke Hospital, Thessaloniki, Not set
General Hospital Of Thessaloniki Papageorgiou, Thessaloniki, Not set
Queen Mary Hospital, The University of Hong Kong, Hong Kong, Not set
Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set
IRCCS Istituto Clinico Humanitas, Rozzano MI, Not set
Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona, Not set
Aichi Cancer Center, Nagoya-shi, Aichi
National Cancer Center Hospital East, Kashiwa-shi, Chiba
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama-shi, Kanagawa
National Cancer Center Hospital, Chuo-ku, Tokyo
Radboud Universitair Medisch Centrum, Nijmegen, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Andalucía
Hospital Universitari Vall d Hebron, Barcelona, Cataluña
Hospital General Universitario Gregorio Maranon, Madrid, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Queen Elizabeth Hospital Birmingham, Birmingham, Not set
Sarah Cannon Research Institute UK, London, Not set
Conditions: Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
Recruiting
DESTINY-Endometrial01 will investigate the efficacy of first-line T-DXd + rilvegostomig (Arm A) and/or T-DXd+ pembrolizumab (Arm B) when compared to chemotherapy (carboplatin + paclitaxel) + pembrolizumab (Arm C), by assessment of progression free survival (PFS), as assessed by BICR, in participants with HER2-expressing (IHC 3+/2+), pMMR, primary advanced (Stage III/IV) or recurrent EC.
DESTINY-Endometrial01 will investigate the efficacy of first-line T-DXd + rilvegostomig (Arm A) and/or T-DXd+ pembrolizumab (Arm B) when compared to chemotherapy (carboplatin + paclitaxel) + pembrolizumab (Arm C), by assessment of progression free survival (PFS), as assessed by BICR, in participants with HER2-expressing (IHC 3+/2+), pMMR, primary advanced (Stage III/IV) or recurrent EC. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Research Site, Tucson, Arizona +237 locations
Research Site, Tucson, Arizona
Research Site, Little Rock, Arkansas
Research Site, La Jolla, California
Research Site, Palo Alto, California
Research Site, Sylmar, California
Research Site, Fort Myers, Florida
Research Site, Miami Beach, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tampa, Florida
Research Site, West Palm Beach, Florida
Research Site, Augusta, Georgia
Research Site, Honolulu, Hawaii
Research Site, Evanston, Illinois
Research Site, Niles, Illinois
Research Site, Shreveport, Louisiana
Research Site, Baltimore, Maryland
Research Site, Boston, Massachusetts
Research Site, Worcester, Massachusetts
Research Site, Ann Arbor, Michigan
Research Site, Detroit, Michigan
Research Site, Minneapolis, Minnesota
Research Site, Rochester, Minnesota
Research Site, Jackson, Mississippi
Research Site, Saint Louis, Missouri
Research Site, Las Vegas, Nevada
Research Site, Hackensack, New Jersey
Research Site, Albuquerque, New Mexico
Research Site, New York, New York
Research Site, New York, New York
Research Site, New York, New York
Research Site, Charlotte, North Carolina
Research Site, Winston-Salem, North Carolina
Research Site, Cincinnati, Ohio
Research Site, Tulsa, Oklahoma
Research Site, Eugene, Oregon
Research Site, Abington, Pennsylvania
Research Site, Hershey, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Providence, Rhode Island
Research Site, Charleston, South Carolina
Research Site, Sioux Falls, South Dakota
Research Site, Austin, Texas
Research Site, Fredericksburg, Texas
Research Site, Houston, Texas
Research Site, Irving, Texas
Research Site, Saint Johnsbury, Vermont
Research Site, Charlottesville, Virginia
Research Site, Seattle, Washington
Research Site, Madison, Wisconsin
Research Site, Blacktown, Not set
Research Site, East Melbourne, Not set
Research Site, Nedlands, Not set
Research Site, South Brisbane, Not set
Research Site, Innsbruck, Not set
Research Site, Linz, Not set
Research Site, Vienna, Not set
Research Site, Wein, Not set
Research Site, Anderlecht, Not set
Research Site, Brussel, Not set
Research Site, Charleroi, Not set
Research Site, Gent, Not set
Research Site, Leuven, Not set
Research Site, Liège, Not set
Research Site, Barretos, Not set
Research Site, Belo Horizonte, Not set
Research Site, Goiânia, Not set
Research Site, Londrina, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Salvador, Not set
Research Site, Sao Paulo, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Teresina, Not set
Research Site, Calgary, Alberta
Research Site, Edmonton, Alberta
Research Site, Winnipeg, Manitoba
Research Site, Halifax, Nova Scotia
Research Site, London, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Montréal, Quebec
Research Site, Montréal, Quebec
Research Site, Québec, Quebec
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Fuzhou, Not set
Research Site, Fuzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Haikou City, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Hefei, Not set
Research Site, Jinan, Not set
Research Site, Jinan, Not set
Research Site, Jining, Not set
Research Site, Kunming, Not set
Research Site, Lanzhou, Not set
Research Site, Nanchang, Not set
Research Site, Nanning, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shantou, Not set
Research Site, Shenyang, Not set
Research Site, Shenyang, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Urumqi, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xian, Not set
Research Site, Xuzhou, Not set
Research Site, Yibin, Not set
Research Site, Aalborg, Not set
Research Site, Herlev, Not set
Research Site, København Ø, Not set
Research Site, Odense, Not set
Research Site, Helsinki, Not set
Research Site, Oulu, Not set
Research Site, Tampere, Not set
Research Site, Turku, Not set
Research Site, Besançon Cedex, Not set
Research Site, Bordeaux, Not set
Research Site, Caen cedex 05, Not set
Research Site, Clermont-Ferrand, Not set
Research Site, Lyon, Not set
Research Site, Montpellier, Not set
Research Site, Nice, Not set
Research Site, Paris, Not set
Research Site, Plerin, Not set
Research Site, Poitiers, Not set
Research Site, Saint Herblain, Not set
Research Site, Toulouse, Not set
Research Site, Berlin, Not set
Research Site, Chemnitz, Not set
Research Site, Dessau-Roßlau, Not set
Research Site, Dresden, Not set
Research Site, Essen, Not set
Research Site, Hamburg, Not set
Research Site, Kassel, Not set
Research Site, Leipzig, Not set
Research Site, Mannheim, Not set
Research Site, Marburg, Not set
Research Site, Münster, Not set
Research Site, Saarbrücken, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Catania, Not set
Research Site, Firenze, Not set
Research Site, Milano, Not set
Research Site, Milan, Not set
Research Site, Milan, Not set
Research Site, Monza, Not set
Research Site, Napoli, Not set
Research Site, Reggio Emilia, Not set
Research Site, Roma, Not set
Research Site, Rome, Not set
Research Site, Torino, Not set
Research Site, Turin, Not set
Research Site, Akashi-shi, Not set
Research Site, Hidaka-shi, Not set
Research Site, Isehara-shi, Not set
Research Site, Kashiwa-shi, Not set
Research Site, Kashiwa, Not set
Research Site, Kobe-shi, Not set
Research Site, Koto-ku, Not set
Research Site, Kurume-shi, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Morioka-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nakagami-gun, Not set
Research Site, Niigata-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Ota-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Shinjuku-ku, Not set
Research Site, Sunto-gun, Not set
Research Site, Tokyo, Not set
Research Site, Goyang-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon-si, Not set
Research Site, Amsterdam, Not set
Research Site, Leiden, Not set
Research Site, Nijmegen, Not set
Research Site, Rotterdam, Not set
Research Site, Oslo, Not set
Research Site, Stavanger, Not set
Research Site, Białystok, Not set
Research Site, Gdańsk, Not set
Research Site, Poznan, Not set
Research Site, Siedlce, Not set
Research Site, Szczecin, Not set
Research Site, Łódź, Not set
Research Site, A Coruña, Not set
Research Site, Córdoba, Not set
Research Site, El Palmar, Not set
Research Site, L'Hospitalet de Llobregat, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Palma de Mallorca, Not set
Research Site, San Sebastian, Not set
Research Site, Valencia, Not set
Research Site, Valencia, Not set
Research Site, Zaragoza, Not set
Research Site, Linköping, Not set
Research Site, Lund, Not set
Research Site, Stockholm, Not set
Research Site, Uppsala, Not set
Research Site, Frauenfeld, Not set
Research Site, Liestal, Not set
Research Site, Zürich, Not set
Research Site, Changhua, Not set
Research Site, Kaohsiung, Not set
Research Site, New Taipei, Not set
Research Site, Taichung, Not set
Research Site, Tainan, Not set
Research Site, Taipei, Not set
Research Site, Bath, Not set
Research Site, Cambridge, Not set
Research Site, Leeds, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Northwood, Not set
Research Site, Taunton, Not set
Conditions: Endometrial Cancer
A Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)
Not Yet Recruiting
The purpose of this study is to assess the safety and efficacy of BMS-986504, a selective, MTA-cooperative PRMT5 inhibitor, in combination with Nab-paclitaxel/Gemcitabine (nab-p/gem) versus placebo in combination with nab-p/gem, in participants with untreated metastatic Pancreatic Ductal Adenocarcinoma (PDAC) with homozygous methylthioadenosine phosphorylase (MTAP) deletion.
The purpose of this study is to assess the safety and efficacy of BMS-986504, a selective, MTA-cooperative PRMT5 inhibitor, in combination with Nab-paclitaxel/Gemcitabine (nab-p/gem) versus placebo in combination with nab-p/gem, in participants with untreated metastatic Pancreatic Ductal Adenocarcinoma (PDAC) with homozygous methylthioadenosine phosphorylase (MTAP) deletion. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Local Institution - 0142, Phoenix, Arizona +262 locations
Local Institution - 0142, Phoenix, Arizona
Local Institution - 0306, Springdale, Arkansas
Local Institution - 0157, San Francisco, California
Local Institution - 0139, Jacksonville, Florida
Local Institution - 0132, Tampa, Florida
Local Institution - 0193, Marietta, Georgia
Local Institution - 0126, Boise, Idaho
Local Institution - 0168, Chicago, Illinois
Local Institution - 0125, Westwood, Kansas
Local Institution - 0145, Baltimore, Maryland
Local Institution - 0245, Boston, Massachusetts
Local Institution - 0120, Boston, Massachusetts
Local Institution - 0191, Detroit, Michigan
Local Institution - 0192, Grand Rapids, Michigan
Local Institution - 0182, Rochester, Minnesota
Local Institution - 0290, Omaha, Nebraska
Local Institution - 0144, Buffalo, New York
Local Institution - 0146, New Hyde Park, New York
Local Institution - 0143, New York, New York
Local Institution - 0140, New York, New York
Local Institution - 0279, New York, New York
Local Institution - 0161, Rochester, New York
Local Institution - 0129, Chapel Hill, North Carolina
Local Institution - 0184, Portland, Oregon
Local Institution - 0162, Portland, Oregon
Local Institution - 0250, Bethlehem, Pennsylvania
Local Institution - 0301, Lancaster, Pennsylvania
Local Institution - 0158, Philadelphia, Pennsylvania
Local Institution - 0289, Pittsburgh, Pennsylvania
Local Institution - 0167, Nashville, Tennessee
Local Institution - 0244, Nashville, Tennessee
Local Institution - 0196, Dallas, Texas
Local Institution - 0164, Houston, Texas
Local Institution - 0159, Fairfax, Virginia
Local Institution - 0348, Norfolk, Virginia
Local Institution - 0337, Seattle, Washington
Local Institution - 0195, Milwaukee, Wisconsin
Local Institution - 0042, Ciudad autónoma de Buenos Aires, Buenos Aires
Local Institution - 0041, Ciudad Autónoma de Buenos Aires, Buenos Aires
Local Institution - 0044, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0069, San Miguel de Tucuman, Tucumán
Local Institution - 0040, Buenos Aires, Not set
Local Institution - 0045, Córdoba, Not set
Local Institution - 0227, St Leonards, New South Wales
Local Institution - 0228, Brisbane, Queensland
Local Institution - 0226, Brisbane, Queensland
Local Institution - 0229, Woodville, South Australia
Local Institution - 0232, Malvern, Victoria
Local Institution - 0231, Melbourne, Victoria
Local Institution - 0230, Murdoch, Western Australia
Local Institution - 0213, Linz, Oberösterreich
Local Institution - 0223, Salzburg, Not set
Local Institution - 0211, Wien, Not set
Local Institution - 0031, Bonheiden, Antwerpen
Local Institution - 0035, Edegem, Antwerpen
Local Institution - 0065, Brussels, Bruxelles-Capitale, Région De
Local Institution - 0063, Brussels, Bruxelles-Capitale, Région De
Local Institution - 0033, Gent, Oost-Vlaanderen
Local Institution - 0032, Leuven, Vlaams-Brabant
Local Institution - 0034, Liège, Not set
Local Institution - 0291, Salvador, Bahia
Local Institution - 0102, Vitória, Espírito Santo
Local Institution - 0101, Belo Horizonte, Minas Gerais
Local Institution - 0074, Natal, Rio Grande Do Norte
Local Institution - 0104, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0071, Barretos, São Paulo
Local Institution - 0100, Rio de Janeiro, Not set
Local Institution - 0075, São Paulo, Not set
Local Institution - 0332, São Paulo, Not set
Local Institution - 0199, Calgary, Alberta
Local Institution - 0200, Vancouver, British Columbia
Local Institution - 0202, Halifax, Nova Scotia
Local Institution - 0201, Toronto, Ontario
Local Institution - 0203, Toronto, Ontario
Local Institution - 0215, Montreal, Quebec
Local Institution - 0048, Santiago, Región Metropolitana De Santiago
Local Institution - 0046, Santiago, Región Metropolitana De Santiago
Local Institution - 0047, Santiago, Región Metropolitana De Santiago
Local Institution - 0156, Viña del Mar, Valparaíso
Local Institution - 0312, Hefei, Anhui
Local Institution - 0331, Hefei, Anhui
Local Institution - 0346, Beijing, Beijing
Local Institution - 0310, Beijing, Beijing
Local Institution - 0307, Chongqing, Chongqing
Local Institution - 0296, Fuzhou, Fujian
Local Institution - 0297, Fuzhou, Fujian
Local Institution - 0352, Guangzhou, Guangdong
Local Institution - 0313, Guangzhou, Guangdong
Local Institution - 0302, Harbin, Heilongjiang
Local Institution - 0295, Luoyang, Henan
Local Institution - 0353, Zhengzhou, Henan
Local Institution - 0357, Wuhan, Hubei
Local Institution - 0298, Wuhan, Hubei
Local Institution - 0293, Changsha, Hunan
Local Institution - 0354, Changzhou, Jiangsu
Local Institution - 0303, Nanjing, Jiangsu
Local Institution - 0311, Nanjing, Jiangsu
Local Institution - 0304, Shenyang, Liaoning
Local Institution - 0345, Xi'an, Shaanxi
Local Institution - 0299, Jinan, Shandong
Local Institution - 0334, Jining, Shandong
Local Institution - 0239, Shanghai Shi, Shanghai
Local Institution - 0292, Shanghai, Shanghai
Local Institution - 0355, Shanghai, Shanghai
Local Institution - 0300, Shanghai, Shanghai
Local Institution - 0351, Taiyuan, Shanxi
Local Institution - 0305, Cheng Du, Sichuan
Local Institution - 0308, Chengdu, Sichuan
Local Institution - 0314, Tianjin, Tianjin
Local Institution - 0356, Hangzhou, Zhejiang
Local Institution - 0294, Hangzhou, Zhejiang
Local Institution - 0267, Medellín, Antioquia
Local Institution - 0338, Rionegro, Antioquia
Local Institution - 0269, Montería, Córdoba
Local Institution - 0268, Pereira, Risaralda
Local Institution - 0266, Bogotá, Not set
Local Institution - 0057, Brno, Brno-město
Local Institution - 0060, Hradec Kralove, Hradec Králové
Local Institution - 0070, Olomouc, Olomoucký Kraj
Local Institution - 0058, Prague, Praha 4
Local Institution - 0119, Praha, Praha 5
Local Institution - 0130, Praha 2, Not set
Local Institution - 0019, Copenhagen, Hovedstaden
Local Institution - 0116, Aarhus, Midtjylland
Local Institution - 0021, Aalborg, Nordjylland
Local Institution - 0020, Odense, Syddanmark
Local Institution - 0018, Vejle, Syddanmark
Local Institution - 0180, Clermont-Ferrand, Auvergne
Local Institution - 0064, Dijon, Côte-d'Or
Local Institution - 0062, Besançon, Doubs
Local Institution - 0026, Toulouse, Haute-Garonne
Local Institution - 0068, Saint-Cloud, Hauts-de-Seine
Local Institution - 0029, Montpellier, Hérault
Local Institution - 0025, Vandoeuvre lès Nancy, Meurthe-et-Moselle
Local Institution - 0238, Marseille, Provence-Alpes-Côte-d'Azur
Local Institution - 0276, Bayonne, Pyrénées-Atlantiques
Local Institution - 0067, Lyon, Rhône-Alpes
Local Institution - 0030, Villejuif, Val-de-Marne
Local Institution - 0066, Poitiers, Vienne
Local Institution - 0028, Paris, Not set
Local Institution - 0309, Villejuif, Not set
Local Institution - 0242, München, Bayern
Local Institution - 0209, Frankfurt, Hessen
Local Institution - 0204, Göttingen, Niedersachsen
Local Institution - 0205, Bochum, Nordrhein-Westfalen
Local Institution - 0243, Chemnitz, Sachsen
Local Institution - 0224, Dresden, Sachsen
Local Institution - 0236, Berlin, Not set
Local Institution - 0207, Hamburg, Not set
Local Institution - 0206, Köln, Not set
Local Institution - 0208, Ulm, Not set
Local Institution - 0085, Athens, Attikí (Region)
Local Institution - 0084, Athens, Attikí
Local Institution - 0259, Heraklion, Irakleío
Local Institution - 0091, Thessaloniki, Kentrikí Makedonía
Local Institution - 0082, Thessaloniki, Thessaloníki
Local Institution - 0083, Larissa, Thessalía
Local Institution - 0086, Athens, Not set
Local Institution - 0271, Hong Kong, Not set
Local Institution - 0270, Shatin, Not set
Local Institution - 0152, New Delhi, Delhi
Local Institution - 0188, Kochi, Kerala
Local Institution - 0179, Bhubaneswar, Odisha
Local Institution - 0190, Hyderabad, Telangana
Local Institution - 0147, Hyderabad, Telangana
Local Institution - 0154, Varanasi, Uttar Pradesh
Local Institution - 0153, Kolkata, West Bengal
Local Institution - 0225, Dublin, Not set
Local Institution - 0078, Ramat Gan, HaMerkaz
Local Institution - 0080, Zerifin, HaMerkaz
Local Institution - 0077, Afula, HaTsafon
Local Institution - 0076, Tel Aviv, Tell Abīb
Local Institution - 0097, Jerusalem, Yerushalayim
Local Institution - 0081, Petah Tikva, Not set
Local Institution - 0094, Naples, Campania
Local Institution - 0095, Meldola, Emilia-Romagna
Local Institution - 0092, Roma, Lazio
Local Institution - 0089, Milan, Lombardia
Local Institution - 0088, Rozzano, Milano
Local Institution - 0096, Pisa, Toscana
Local Institution - 0093, Padova, Veneto
Local Institution - 0247, Milano, Not set
Local Institution - 0090, Verona, Not set
Local Institution - 0222, Nagoya, Aichi
Local Institution - 0217, Kashiwa, Chiba
Local Institution - 0219, Sapporo, Hokkaido
Local Institution - 0218, Yokohama, Kanagawa
Local Institution - 0216, Chuo-ku, Tokyo
Local Institution - 0220, Koto, Tokyo
Local Institution - 0221, Osaka, Not set
Local Institution - 0049, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0051, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0050, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0257, Kuching, Sarawak
Local Institution - 0258, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0256, Lembah Pantai, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0261, Cuauhtémoc, Ciudad De México, Distrito Federal
Local Institution - 0260, Mexico City, Distrito Federal
Local Institution - 0364, Zapopan, Jalisco
Local Institution - 0264, Monterrey, Nuevo León
Local Institution - 0265, Oaxaca de Juarez, Oaxaca
Local Institution - 0281, Santiago de Queretaro, Querétaro
Local Institution - 0263, Mexico City, Not set
Local Institution - 0262, Puebla, Not set
Local Institution - 0038, Maastricht, Limburg
Local Institution - 0039, Breda, Noord-Brabant
Local Institution - 0277, Leiden, Zuid-Holland
Local Institution - 0037, Rotterdam, Zuid-Holland
Local Institution - 0280, Warszawa, Mazowieckie
Local Institution - 0251, Gdask, Pomorskie
Local Institution - 0278, Poznań, Wielkopolskie
Local Institution - 0363, Gdansk, Not set
Local Institution - 0112, Cluj-Napoca, Cluj
Local Institution - 0111, Florești, Cluj
Local Institution - 0110, Craiova, Dolj
Local Institution - 0108, Ploiești, Prahova
Local Institution - 0114, București, Not set
Local Institution - 0109, București, Not set
Local Institution - 0113, Cluj, Not set
Local Institution - 0115, Cluj, Not set
Local Institution - 0107, Iași, Not set
Local Institution - 0254, Singapore, Central Singapore
Local Institution - 0255, Singapore, Not set
Local Institution - 0252, Singapore, Not set
Local Institution - 0253, Singapore, Not set
Local Institution - 0272, Banska Bystrica, Banskobystrický Kraj
Local Institution - 0273, Kosice, Košický Kraj
Local Institution - 0274, Trencin, Trenčiansky Kraj
Local Institution - 0275, Bratislava, Not set
Local Institution - 0246, Johannesburg, Gauteng
Local Institution - 0241, Pretoria, Gauteng
Local Institution - 0240, Soweto, Gauteng
Local Institution - 0335, Cape Town, Western Cape
Local Institution - 0003, Barcelona, Barcelona [Barcelona]
Local Institution - 0005, Barcelona, Catalunya [Cataluña]
Local Institution - 0007, Madrid, Madrid, Comunidad De
Local Institution - 0004, Madrid, Madrid, Comunidad De
Local Institution - 0002, Madrid, Not set
Local Institution - 0006, Sevilla, Not set
Local Institution - 0001, Zaragoza, Not set
Local Institution - 0249, Lund, Skåne Län [se-12]
Local Institution - 0023, Solna, Stockholms Län [se-01]
Local Institution - 0022, Uppsala, Uppsala Län [se-03]
Local Institution - 0118, Gothenburg, Västra Götalands Län [se-14]
Local Institution - 0212, Bern, Berne
Local Institution - 0214, st.Gallen, Sankt Gallen
Local Institution - 0210, Bellinzona, Ticino
Local Institution - 0234, Geneva, Not set
Local Institution - 0052, Taichung, Not set
Local Institution - 0056, Taipei, Not set
Local Institution - 0053, Taipei, Not set
Local Institution - 0054, Taoyuan, Not set
Local Institution - 0284, Stanbul, İstanbul
Local Institution - 0283, Adana, Not set
Local Institution - 0286, Ankara, Not set
Local Institution - 0287, Ankara, Not set
Local Institution - 0285, Istanbul, Not set
Local Institution - 0098, Birmingham, England
Local Institution - 0014, London, England
Local Institution - 0017, London, Kensington And Chelsea
Local Institution - 0248, London, London, City Of
Local Institution - 0013, London, London, City Of
Local Institution - 0235, Wirral, Not set
Conditions: Pancreatic Ductal Adenocarcinoma
A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)
Recruiting
Researchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy.
Researchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Ironwood Cancer & Research Centers ( Site 0036), Chandler, Arizona +93 locations
Ironwood Cancer & Research Centers ( Site 0036), Chandler, Arizona
Yale New Haven Hospital ( Site 0001), New Haven, Connecticut
AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0007), Altamonte Springs, Florida
St. Luke's Cancer Institute: Boise ( Site 0037), Boise, Idaho
MedStar Franklin Square Medical Center ( Site 0031), Baltimore, Maryland
MedStar Good Samaritan Hospital ( Site 0079), Baltimore, Maryland
MedStar Montgomery Medical Center ( Site 0078), Olney, Maryland
Holy Cross Hospital ( Site 0091), Silver Spring, Maryland
Allina Health Cancer Institute ( Site 0069), Minneapolis, Minnesota
Comprehensive Cancer Centers of Nevada ( Site 0015), Las Vegas, Nevada
Renown Regional Medical Center ( Site 0005), Reno, Nevada
New Mexico Oncology Hematology Consultants Ltd. ( Site 0019), Albuquerque, New Mexico
Instituto Alexander Fleming ( Site 2402), Mar De PLata, Buenos Aires
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2401), Mar del Plata, Buenos Aires
Clinica Viedma ( Site 2403), Viedma, Rio Negro
Fundacion Estudios Clinicos ( Site 2405), Rosario, Santa Fe
Hospital Italiano de Cordoba ( Site 2406), Cordoba, Not set
AZ Maria Middelares ( Site 3103), Gent, Oost-Vlaanderen
ZAS Sint Augustinus ( Site 3102), Antwerpen, Vlaams Gewest
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 2301), São Jose do Rio Preto, Sao Paulo
Jewish General Hospital ( Site 0203), Montreal, Quebec
St. Marys Hospital Center ( Site 0201), Montreal, Quebec
Hopital Du Saint-Sacrement ( Site 0210), Québec, Quebec
Biocenter ( Site 2009), Concepcion, Biobio
IC La Serena Research ( Site 2007), La Serena, Coquimbo
FALP ( Site 2000), Santiago., Region M. De Santiago
Clínica UC San Carlos de Apoquindo ( Site 2008), Santiago, Region M. De Santiago
Bradfordhill ( Site 2001), Santiago, Region M. De Santiago
ONCOCENTRO APYS ( Site 2005), Vina del Mar, Valparaiso
The First Afflilated Hospital of Bengbu Medical College ( Site 5022), Bengbu, Anhui
The First Affiliated Hospital of Chongqing Medical University ( Site 5039), Chongqing, Chongqing
Chongqing University Three Gorges Hospital ( Site 5020), Chongqing, Chongqing
Sun Yat-Sen University Cancer Center ( Site 5014), Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital. ( Site 5008), Nanning, Guangxi
Jiangsu Province Hospital ( Site 5009), Nanjing, Jiangsu
Xuzhou Central Hospital ( Site 5036), Xuzhou, Jiangsu
The First Hospital of Jilin University ( Site 5003), Changchun, Jilin
Jinan Central Hospital ( Site 5031), Jinan, Shandong
LinYi Cancer Hospital ( Site 5021), Linyi, Shandong
Sichuan Cancer Hospital. ( Site 5018), Chengdu, Sichuan
Affiliated Tumor Hospital of Xinjiang Medical University ( Site 5006), Urumqi, Xinjiang
Zhejiang Cancer Hospital ( Site 5012), Hangzhou, Zhejiang
The Second Affiliated hospital of Zhejiang University school of medicine ( Site 5024), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 5029), Linhai, Zhejiang
Instituto de Cancerología ( Site 2206), Medellin., Antioquia
Centro Cancerologico del Caribe LTD ( Site 2209), Barranquilla, Atlantico
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2203), Bogota., Distrito Capital De Bogota
Rambam Health Care Campus ( Site 3700), Haifa, Not set
Shaare Zedek Medical Center ( Site 3704), Jerusalem, Not set
Rabin Medical Center ( Site 3702), Petah Tikva, Not set
Sheba Medical Center ( Site 3701), Ramat Gan, Not set
Sourasky Medical Center ( Site 3703), Tel Aviv, Not set
Nagoya City University Hospital ( Site 5108), Nagoya, Aichi
Hokkaido University Hospital ( Site 5100), Sapporo, Hokkaido
Tokai University Hospital ( Site 5107), Isehara, Kanagawa
Mie University Hospital ( Site 5109), Tsu, Mie
The University of Osaka Hospital ( Site 5111), Suita, Osaka
Saitama Medical University International Medical Center ( Site 5116), Hidaka, Saitama
Showa Medical University Hospital ( Site 5103), Shinagawa, Tokyo
Fukushima Medical University Hospital ( Site 5101), Fukushima, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 5113), Hiroshima, Not set
Social medical corporation Hakuaikai Sagara Hospital ( Site 5114), Kagoshima, Not set
National Cancer Center ( Site 5202), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 5204), Seongnam, Kyonggi-do
Kyungpook National University Chilgok Hospital ( Site 5205), Daegu, Kyongsangbuk-do
Seoul National University Hospital ( Site 5200), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 5201), Seoul, Not set
Samsung Medical Center ( Site 5203), Seoul, Not set
Harbour Cancer & Wellness ( Site 5600), Newmarket, Auckland
Pratia MCM Krakow ( Site 3812), Krakow, Malopolskie
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3801), Siedlce, Mazowieckie
Mazowiecki Szpital Onkologiczny ( Site 3807), Wieliszew, Mazowieckie
Szpitale Pomorskie Sp. z o. o. ( Site 3805), Gdynia, Pomorskie
Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie ( Site 3800), Koszalin, Zachodniopomorskie
Institutul Oncologic Cluj ( Site 4701), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 4705), Comuna Floresti, Cluj
Centrul de Oncologie "Sfântul Nectarie" ( Site 4702), Craiova, Dolj
Centrul Medical Neolife- Baneasa ( Site 4706), Bucuresti, Not set
Hospital Clinico San Carlos ( Site 4100), Madrid, Madrid, Comunidad De
Hospital General Universitario de Valencia ( Site 4102), Valencia, Valenciana, Comunitat
Parc de Salut Mar - Hospital del Mar ( Site 4106), Barcelona, Not set
Hospital Beata María Ana ( Site 4105), Madrid, Not set
Hospital Universitario Ramon y Cajal ( Site 4103), Madrid, Not set
Taichung Veterans General Hospital ( Site 5303), Taichung, Not set
National Cheng Kung University Hospital ( Site 5304), Tainan, Not set
National Taiwan University Hospital ( Site 5300), Taipei, Not set
Mackay Memorial Hospital ( Site 5301), Taipei, Not set
Chang Gung Memorial Hospital ( Site 5302), Taoyuan, Not set
Faculty of Medicine Siriraj Hospital ( Site 5800), Bangkok, Krung Thep Maha Nakhon
Songklanagarind hospital ( Site 5801), HatYai, Songkhla
Faculty of Medicine - Khon Kaen University ( Site 5802), Khon Kaen, Not set
Royal Cornwall Hospital ( Site 4003), Truro, Cornwall
St Bartholomew's Hospital ( Site 4001), London, London, City Of
Nottingham University Hospital NHS Trust ( Site 4009), Nottingham, Nottinghamshire
Conditions: Triple Negative Breast Neoplasms
Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)
Recruiting
Researchers are looking for new ways to treat people with endometrial cancer (EC) who have previously received treatment with platinum based therapy (a type of chemotherapy) and immunotherapy. Immunotherapy is a treatment that helps the immune system fight cancer. This clinical study will compare sacituzumab tirumotecan to chemotherapy. The goal of the study is to learn if people who receive sacituzumab tirumotecan live longer overall and without the cancer getting worse compared to people who r... Read More
Researchers are looking for new ways to treat people with endometrial cancer (EC) who have previously received treatment with platinum based therapy (a type of chemotherapy) and immunotherapy. Immunotherapy is a treatment that helps the immune system fight cancer. This clinical study will compare sacituzumab tirumotecan to chemotherapy. The goal of the study is to learn if people who receive sacituzumab tirumotecan live longer overall and without the cancer getting worse compared to people who receive chemotherapy. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: USA Mitchell Cancer Institute ( Site 4142), Mobile, Alabama +241 locations
USA Mitchell Cancer Institute ( Site 4142), Mobile, Alabama
Alaska Womens Cancer Care ( Site 4122), Anchorage, Alaska
HonorHealth (HH) ( Site 8000), Phoenix, Arizona
Arizona Oncology Associates - HOPE ( Site 8002), Tucson, Arizona
UCLA Hematology/Oncology - Westwood (Building 100)-Department of OBGYN, Division of Gynecologic Onc ( Site 4131), Los Angeles, California
California Pacific Medical Center - Van Ness Campus ( Site 4129), San Francisco, California
Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 4114), New Haven, Connecticut
MedStar Washington Hospital Center ( Site 4108), Washington, District of Columbia
Mount Sinai Cancer Center ( Site 4117), Miami Beach, Florida
AdventHealth Orlando-AdventHealth Medical Group Gynecological Oncology ( Site 4113), Orlando, Florida
Florida Cancer Specialists - East ( Site 7000), West Palm Beach, Florida
Northside Hospital ( Site 4112), Atlanta, Georgia
Augusta University ( Site 4116), Augusta, Georgia
Centricity Research Columbus Cancer Center ( Site 4154), Columbus, Georgia
NorthShore University HealthSystem - Evanston Hospital ( Site 4110), Evanston, Illinois
Parkview Research Center at Parkview Regional Medical Center ( Site 4132), Fort Wayne, Indiana
Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 4150), Edgewood, Kentucky
University Medical Center New Orleans ( Site 4133), New Orleans, Louisiana
TRIALS 365 ( Site 4105), Shreveport, Louisiana
University of Massachusetts Memorial Medical Center ( Site 4103), Worcester, Massachusetts
Washington University School of Medicine-Obstetrics & Gynecology ( Site 4146), Saint Louis, Missouri
The Center of Hope ( Site 4109), Reno, Nevada
John Theurer Cancer Center at Hackensack University Medical Center ( Site 4118), Hackensack, New Jersey
Atlantic Health System Morristown Medical Center ( Site 4135), Morristown, New Jersey
Holy Name Medical Center ( Site 4115), Teaneck, New Jersey
New York - Presbyterian Brooklyn Methodist Hospital ( Site 4134), Brooklyn, New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 4156), Mineola, New York
Laura and Isaac Perlmutter Cancer Center ( Site 4106), New York, New York
Icahn School of Medicine at Mount Sinai-Department of Obstetrics, Gynecology, and Reproductive Scie ( Site 4128), New York, New York
Good Samaritan Hospital Medical Center ( Site 4139), West Islip, New York
Duke Cancer Institute ( Site 4120), Durham, North Carolina
Sanford Health Roger Maris Cancer Center ( Site 4158), Fargo, North Dakota
University of Cincinnati Medical Center ( Site 4136), Cincinnati, Ohio
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 4125), Columbus, Ohio
Sidney Kimmel Cancer Center - Jefferson Health ( Site 4157), Philadelphia, Pennsylvania
AHN West Penn Hospital-Gynecologic Oncology ( Site 4111), Pittsburgh, Pennsylvania
Asplundh Cancer Pavilion ( Site 4107), Willow Grove, Pennsylvania
Women & Infants Hospital ( Site 4138), Providence, Rhode Island
Sanford Cancer Center-Gynecologic Oncology ( Site 4121), Sioux Falls, South Dakota
The West Clinic, PLLC dba West Cancer Center ( Site 4102), Germantown, Tennessee
Houston Methodist Hospital-Obstetrics and Gynecology ( Site 4130), Houston, Texas
Texas Oncology - San Antonio ( Site 8005), San Antonio, Texas
Texas Oncology - Gulf Coast ( Site 8006), The Woodlands, Texas
Hospital Británico de Buenos Aires-Oncology ( Site 1002), Ciudad autónoma de Buenos Aires, Buenos Aires
Instituto Argentino de Diagnóstico y Tratamiento (IADT) ( Site 1008), Buenos Aires, Caba
Instituto Alexander Fleming-Alexander Fleming ( Site 1007), Ciudad Autónoma de Buenos Aires, Caba
Hospital Aleman-Oncology ( Site 1001), Buenos Aires, Not set
Instituto de Oncología Angel H. Roffo ( Site 1003), Buenos Aires, Not set
Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 1004), Buenos Aires, Not set
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 1006), La Rioja, Not set
GenesisCare North Shore ( Site 1103), St Leonards, New South Wales
Blacktown Hospital ( Site 1101), Sydney, New South Wales
Royal Brisbane and Women's Hospital ( Site 1102), Brisbane, Queensland
Epworth Freemasons ( Site 1104), East Melbourne, Victoria
Frankston Hospital ( Site 1105), Frankston, Victoria
Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 1201), Innsbruck, Tirol
Medizinische Universität Wien ( Site 1202), Wien, Not set
AZ Maria Middelares-IKG ( Site 1305), Gent, Oost-Vlaanderen
UZ Gent-Medical oncology ( Site 1303), Gent, Oost-Vlaanderen
UZ Leuven-Gynecologic Oncology ( Site 1301), Leuven, Vlaams-Brabant
AZ Delta vzw-Oncology ( Site 1302), Roeselare, West-Vlaanderen
CHU UCL Namur/Site Sainte Elisabeth-Trial Office ( Site 1304), Namur, Not set
Hospital São Domingos ( Site 1365), Sao Luis, Maranhao
Centro Oncologico do Triangulo ( Site 1360), Uberlândia, Minas Gerais
Hospital Moinhos de Vento ( Site 1359), Porto Alegre, Rio Grande Do Sul
Instituto Joinvilense de Hematologia e Oncologia ( Site 1353), Joinville, Santa Catarina
Instituto de Ensino e Pesquisa ( Site 1355), Sorocaba, Sao Paulo
Instituto de Educação, Pesquisa e Gestão em Saúde ( Site 1352), Rio de Janeiro, Not set
Hospital Samaritano De Sao Paulo ( Site 1367), Sao Paulo, Not set
A. C. Camargo Cancer Center ( Site 1351), Sao Paulo, Not set
IBCC - Núcleo de Pesquisa e Ensino ( Site 1366), Sao Paulo, Not set
Arthur J.E. Child Comprehensive Cancer Centre ( Site 1413), Calgary, Alberta
Cross Cancer Institute ( Site 1414), Edmonton, Alberta
BC Cancer Vancouver ( Site 1415), Vancouver, British Columbia
Trillium Health Partners - Credit Valley Hospital ( Site 1410), Mississauga, Ontario
CIUSSS- saguenay-Lac-Saint-Jean ( Site 1408), Chicoutimi, Quebec
CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 1405), Montreal, Quebec
Centre Hospitalier de l'Université de Montréal ( Site 1403), Montréal, Quebec
McGill University Health Centre ( Site 1404), Montréal, Quebec
James Lind Centro de Investigacion del Cancer ( Site 1504), Temuco, Araucania
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 1505), Santiago., Region M. De Santiago
Pontificia Universidad Catolica de Chile ( Site 1503), Santiago, Region M. De Santiago
Bradfordhill-Clinical Area ( Site 1501), Santiago, Region M. De Santiago
Second Affiliated hospital of Anhui Medical University-Oncology ( Site 1635), Hefei, Anhui
Beijing Obstetric and Gynecology Hospital ( Site 1653), Beijing, Beijing
Fujian Cancer Hospital-Gynecological Oncology Surgery ( Site 1627), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University-Obstetrics and gynecology department ( Site 1613), Xiamen, Fujian
Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 1634), Guangzhou, Guangdong
Sun Yat-sen University Cancer Center ( Site 1604), Guangzhou, Guangdong
Cancer Hospital of Shantou University Medical College ( Site 1642), Shantou, Guangdong
Affiliated Hospital of Guangdong Medical University ( Site 1614), Zhanjiang, Guangdong
Guangxi Medical University Affiliated Tumor Hospital-Gynecological oncology ( Site 1622), Nanning, Guangxi
Hainan General Hospital ( Site 1636), Haikou, Hainan
Harbin Medical University Cancer Hospital-Gynecological Radiotherapy Department ( Site 1652), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 1618), Zhengzhou, Henan
The Second Affiliated Hospital of Zhengzhou University ( Site 1640), Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1621), Wuhan, Hubei
Hubei Cancer Hospital-Hubei Cancer Hospital ( Site 1607), Wuhan, Hubei
Xiangya Hospital Central South University-Gynecology ( Site 1603), Changsha, Hunan
Hunan Cancer Hospital ( Site 1623), Changsha, Hunan
Nanjing First Hospital ( Site 1649), Nanjing, Jiangsu
Jiangxi Maternal and Child Health Hospital-Oncology Department ( Site 1625), Nanchang, Jiangxi
LinYi Cancer Hospital-Gastrology department ( Site 1630), Linyi, Shandong
Obstetrics & Gynecology Hospital of Fudan University ( Site 1617), Shanghai, Shanghai
Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 1626), Shanghai, Shanghai
West China Second University Hospital, Sichuan University ( Site 1602), Chengdu, Sichuan
Sichuan Cancer hospital-Oncology ( Site 1650), Chengdu, Sichuan
Xinjiang Medical University Cancer Hospital - Urumqi ( Site 1648), Urumqi, Xinjiang
Yunnan Province Cancer Hospital-Gynecology Department ( Site 1641), Kunming, Yunnan
The Affiliated Women's Hospital of Zhejiang University-Obstetrics and Gynecology ( Site 1609), Hangzhou, Zhejiang
Zhejiang Cancer Hospital-Oncology ( Site 1601), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 1633), Linhai, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University ( Site 1615), Wenzhou, Zhejiang
Fakultní Nemocnice Brno-Gynekologicko-porodnicka klinika ( Site 1704), Brno, Brno-mesto
Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 1703), Ostrava, Moravskoslezsky Kraj
Nemocnice AGEL Novy Jicin a.s.-Oddeleni radioterapie a onkologie ( Site 1706), Nový Jiín, Novy Jicin
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 1702), Olomouc, Olomoucky Kraj
Fakultni nemocnice Kralovske Vinohrady ( Site 1707), Praha, Praha 10
Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 1705), Praha, Praha 2
Fakultni nemocnice Bulovka-Gynekologicko-porodnicka klinika ( Site 1701), Praha, Praha 8
Herlev and Gentofte Hospital-Department of Oncology ( Site 1801), Copenhagen, Hovedstaden
Rigshospitalet-Dept. of Oncology ( Site 1803), Copenhagen, Hovedstaden
Aarhus Universitetshospital, Skejby ( Site 1802), Aarhus, Midtjylland
Tampereen yliopistollinen sairaala ( Site 1901), Tampere, Pirkanmaa
Kuopion Yliopistollinen Sairaala ( Site 1904), Kuopio, Pohjois-Savo
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1902), Helsinki, Uusimaa
Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1903), Turku, Varsinais-Suomi
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 2002), Bordeaux, Aquitaine
ROC37 ( Site 2010), Chambray Les Tours, Centre
Centre Armoricain de Radiotherapie Imagerie medicale et Oncologie ( Site 2001), Plerin, Cotes-d Armor
CHU Besançon ( Site 2009), Besançon, Doubs
Institut Claudius Regaud ( Site 2006), Toulouse, Haute-Garonne
Institut Regional du Cancer Montpellier ( Site 2008), Montpellier, Herault
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 2003), Rennes, Ille-et-Vilaine
Centre Oscar Lambret ( Site 2007), Lille, Nord-Pas-de-Calais
CENTRE LEON BERARD ( Site 2004), Lyon Cedex08, Rhone-Alpes
Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 2005), Paris, Not set
SLK-Kliniken Heilbronn ( Site 2107), Heilbronn, Baden-Wurttemberg
Universitätsmedizin Mannheim-Department of Obstetrics and Gynecology ( Site 2101), Mannheim, Baden-Wurttemberg
MVZ für Hämatologie und Onkologie Ravensburg GmbH - Studienzentrum ( Site 2110), Ravensburg, Baden-Wurttemberg
Universitaetsklinikum Tuebingen ( Site 2111), Tübingen, Baden-Wurttemberg
Klinikum der Universität München Großhadern-Klinik und Poliklinik für Frauenheilkunde und Geburtshi ( Site 2109), Munich, Bayern
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 2104), Essen, Nordrhein-Westfalen
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur ( Site 2103), Dresden, Sachsen
Charité Campus Virchow-Klinikum ( Site 2102), Berlin, Not set
Agios Andreas Hospital Patras ( Site 2201), Patras, Achaia
Aretaieio Hospital Oncology Unit ( Site 2206), Athens, Attiki
Metropolitan Hospital-2nd Oncology Dept ( Site 2202), Athens, Attiki
Hygeia Hospital ( Site 2204), Marousi, Attiki
Cork University Hospital ( Site 2402), Cork, Not set
Mater Misericordiae University Hospital ( Site 2403), Dublin, Not set
St. James's Hospital-Cancer clinical trials office ( Site 2401), Dublin, Not set
Rambam Health Care Campus-Gyneco-oncology unit ( Site 2502), Haifa, Not set
Edith Wolfson Medical Center ( Site 2501), Holon, Not set
Shaare Zedek Medical Center ( Site 2503), Jerusalem, Not set
Rabin Medical Center ( Site 2505), Petah Tikva, Not set
Sheba Medical Center ( Site 2504), Ramat Gan, Not set
Sourasky Medical Center ( Site 2506), Tel Aviv, Not set
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlin-SSD Oncologia medica Addarii ( Site 2603), Bologna, Emilia-Romagna
CRO-IRCCS ( Site 2609), Aviano, Friuli-Venezia Giulia
AOU Policlinico Umberto I ( Site 2606), Roma, Lazio
Istituto Europeo di Oncologia IRCCS ( Site 2607), Milano, Lombardia
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 2605), Milan, Lombardia
Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 2610), Rozzano, Milano
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'O-Day Hospital Oncologico Multidisciplin ( Site 2613), Candiolo, Torino
Instituto Tumori Giovanni Paolo II-ONCOLOGIA MEDICA ( Site 2604), Bari, Not set
Azienda Ospedaliera Spedali Civili di Brescia-Obstetrics anf gynecology ( Site 2611), Brescia, Not set
Humanitas San Pio X Hospital ( Site 2614), Milano, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale-S.C. Oncologia Sperimentale Uro-Genitale ( Site 2602), Napoli, Not set
Arcispedale Santa Maria Nuova ( Site 2612), Reggio Emilia, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2601), Roma, Not set
Ospedale Mauriziano-Ginecologia e Ostetricia ( Site 2608), Torino, Not set
Aichi Cancer Center ( Site 2714), Nagoya, Aichi
National Hospital Organization Shikoku Cancer Center ( Site 2705), Matsuyama, Ehime
Ehime University Hospital ( Site 2709), Toon, Ehime
Kurume University Hospital ( Site 2703), Kurume, Fukuoka
Gunma Prefectural Cancer Center ( Site 2708), Otashi, Gunma
Hokkaido University Hospital ( Site 2707), Sapporo, Hokkaido
University of Tsukuba Hospital ( Site 2713), Tsukuba, Ibaraki
Iwate Medical University Hospital ( Site 2712), Shiwa-gun, Iwate
Niigata Cancer Center Hospital ( Site 2701), Niigata-shi, Niigata
Saitama Medical University International Medical Center ( Site 2710), Hidaka, Saitama
Shizuoka Cancer Center ( Site 2716), Sunto-gun,, Shizuoka
National Cancer Center Hospital ( Site 2715), Chuo-ku, Tokyo
Cancer Institute Hospital of JFCR ( Site 2706), Koto, Tokyo
Showa Medical University Hospital ( Site 2719), Shinagawa, Tokyo
Keio University Hospital ( Site 2702), Shinjuku, Tokyo
National Hospital Organization Kyushu Cancer Center ( Site 2711), Fukuoka, Not set
Kagoshima City Hospital ( Site 2717), Kagoshima, Not set
Osaka International Cancer Institute ( Site 2718), Osaka, Not set
Seoul National University Bundang Hospital-Obstetrics and Gynecology ( Site 3505), Seongnam, Kyonggi-do
Seoul National University Hospital ( Site 3502), Seoul, Not set
Severance Hospital, Yonsei University Health System-Gynecologic cancer center ( Site 3503), Seoul, Not set
Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 3501), Seoul, Not set
Samsung Medical Center ( Site 3504), Seoul, Not set
Pantai Hospital Kuala Lumpur-Cancer Centre ( Site 2803), Kuala Lumpur, Not set
University Malaya Medical Centre ( Site 2801), Kuala Lumpur, Not set
COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 2902), Coyoacan, Distrito Federal
Higiea Oncologia ( Site 2905), Mexico City, Distrito Federal
CENTRO MEDICO ZAMBRANO HELLION-Centro de Cáncer de Mama ( Site 2901), San Pedro Garza Garcia, Nuevo Leon
Oncare - Unidad Valle ( Site 2906), San Pedro Garza García, Nuevo Leon
Centro de Investigacion Clinica de Oaxaca ( Site 2907), Oaxaca de Juarez, Oaxaca
Radboudumc-Medical Oncology ( Site 3003), Nijmegen, Gelderland
Amsterdam UMC - locatie VUmc ( Site 3004), Amsterdam, Noord-Holland
Leids Universitair Medisch Centrum-Medical Oncology ( Site 3002), Leiden, Zuid-Holland
Stavanger Universitetssykehus ( Site 3103), Stavanger, Rogaland
Universitetssykehuset Nord-Norge HF ( Site 3101), Tromsø, Troms
Sorlandet Sykehus Kristiansand ( Site 3104), Kristiansand, Vest-Agder
Oslo universitetssykehus, Radiumhospitalet ( Site 3102), Oslo, Not set
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3201), Siedlce, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Site 3203), Warszawa, Mazowieckie
Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 3204), Bialystok, Podlaskie
Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie-Oddział Radioterapii i Onkologii Ginek ( Site 3202), Poznan, Wielkopolskie
Ad-Vance Medical Research-Research ( Site 3302), Ponce, Not set
Pan American Center for Oncology Trials - Ciudadela ( Site 3301), San Juan, Not set
UPR Comprehensive Cancer Center-Comprehensive Cancer Center Hospital ( Site 3304), San Juan, Not set
National Cancer Centre Singapore-Medical Oncology ( Site 3401), Singapore, Central Singapore
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 3608), L Hospitalet, Barcelona
Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 3606), Girona, Gerona
Clinica Universidad de Navarra ( Site 3603), Madrid, Madrid, Comunidad De
Hospital Universitario 12 de Octubre-Medical Oncology ( Site 3607), Madrid, Madrid, Comunidad De
Hospital Universitario La Paz-Oncología Médica ( Site 3604), Madrid, Madrid, Comunidad De
Fundación Instituto Valenciano de Oncología-Oncologico ( Site 3605), Valencia, Valenciana, Comunitat
HOSPITAL CLINICO DE VALENCIA ( Site 3609), Valencia, Valenciana, Comunitat
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 3602), Barcelona, Not set
Hospital Universitario Reina Sofia-Oncologia Medica ( Site 3601), Cordoba, Not set
Skånes Universitetssjukhus Lund ( Site 3702), Lund, Skane Lan
Karolinska Universitetssjukhuset Solna ( Site 3701), Stockholm, Stockholms Lan
University Hospital Basel-Gynecology & Gynecologic Oncology ( Site 3808), Basel, Basel-Stadt
Kantonsspital Graubünden-Medizin ( Site 3803), Chur, Grisons
Ospedale Regionale Bellinzona e Valli ( Site 3802), Bellinzona, Ticino
Inselspital Bern-Oncology ( Site 3801), Berne, Not set
University Hospitals Sussex NHS Foundation Trust ( Site 4006), East Sussex, Brighton And Hove
Royal Derby Hospital ( Site 4007), Derby, Derbyshire
ROYAL MARSDEN HOSPITAL (CHELSEA)-Gynaecology Research Centre ( Site 4002), London, England
The Royal Cornwall Hospital ( Site 4009), Truro, England
University College London Hospital-Cancer Clinical Trials Unit ( Site 4004), London, London, City Of
Guy's & St Thomas' NHS Foundation Trust-Oncology & Haematology Clinical Trials ( Site 4008), London, London, City Of
Hammersmith Hospital ( Site 4001), London, London, City Of
The Beatson West of Scotland Cancer Centre ( Site 4005), Glasgow, Scotland
Royal Marsden Hospital (Sutton)-Gynaecology Unit ( Site 4010), London, Sutton
The Christie NHS Foundation Trust-Medical Oncology ( Site 4003), Manchester, Not set
Conditions: Endometrial Cancer
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
Recruiting
This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS).
This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: CARTI Cancer Center ( Site 0006), Little Rock, Arkansas +188 locations
CARTI Cancer Center ( Site 0006), Little Rock, Arkansas
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0122), Burbank, California
Exempla Lutheran Medical Center ( Site 0119), Golden, Colorado
Intermountain Health St. Mary's Regional Hospital ( Site 0116), Grand Junction, Colorado
Mid Florida Hematology and Oncology Center ( Site 0109), Orange City, Florida
Centricity Research Columbus Cancer Center ( Site 0111), Columbus, Georgia
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0001), Marietta, Georgia
University of Chicago Medical Center ( Site 0145), Chicago, Illinois
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0146), Minneapolis, Minnesota
New Mexico Oncology Hematology Consultants Ltd. ( Site 0123), Albuquerque, New Mexico
Thomas Jefferson University - Clinical Research Institute ( Site 0147), Philadelphia, Pennsylvania
Oncology Consultants P.A. ( Site 0124), Houston, Texas
Mays Cancer Center ( Site 0132), San Antonio, Texas
Instituto Alexander Fleming ( Site 0203), Ciudad Autónoma de Buenos Aires, Buenos Aires
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0200), Mar del Plata, Buenos Aires
Instituto Médico Río Cuarto ( Site 0204), Rio Cuarto., Cordoba
Fundacion Intecnus ( Site 0205), San Carlos de Bariloche, Rio Negro
Sanatorio Parque ( Site 0201), Rosario, Santa Fe
Hospital Aleman-Oncology ( Site 0202), Buenos Aires, Not set
Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 0720), Linz, Oberosterreich
Klinik Hietzing ( Site 0740), Wien, Not set
Standort Penzing der Klinik Ottakring-Abteilung für Atemwegs-und Lungenkrankheiten ( Site 0730), Wien, Not set
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 0710), Wien, Not set
Hospital do Cancer de Pernambuco ( Site 0312), Recife, Pernambuco
Oncoclínica Oncologistas Associados ( Site 0309), Terezina, Piaui
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0311), Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceição ( Site 0300), Porto Alegre, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 0304), Santa Cruz do Sul, Rio Grande Do Sul
Hospital de Base de São José do Rio Preto ( Site 0310), São José do Rio Preto, Sao Paulo
Hospital Paulistano ( Site 0307), Sao Paulo, Not set
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0100), Kingston, Ontario
Waterloo Regional Health Network (WRHN) ( Site 0153), Kitchener, Ontario
St. Marys Hospital Center ( Site 0105), Montreal, Quebec
McGill University Health Centre ( Site 0103), Montréal, Quebec
Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0106), Trois-Rivières, Quebec
Centro de Investigación del Maule ( Site 0419), Talca, Maule
FALP ( Site 0409), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0402), Santiago, Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0407), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0400), Viña del Mar, Valparaiso
Bradford Hill Norte ( Site 0420), Antofagasta, Not set
Beijing Cancer Hospital ( Site 2411), Beijing, Beijing
Beijing Cancer hospital-intrathoratic deparmtment II ( Site 2410), Beijing, Beijing
Peking Union Medical College Hospital ( Site 2412), Beijing, Beijing
Army Medical Center of People's Liberation Army-respiratory ( Site 2426), Chongqing, Chongqing
Fujian Provincial Cancer Hospital ( Site 2419), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University-oncology ( Site 2420), Xiamen, Fujian
The First Affiliated Hospital of Guangzhou Medical University ( Site 2417), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 2416), Guangzhou, Guangdong
Harbin Medical University Cancer Hospital-oncology of department ( Site 2415), Harbin, Heilongjiang
Henan Cancer Hospital-Pneumology department ( Site 2423), Zhengzhou, Henan
Tongji Hospital Tongji Medical,Science & Technology ( Site 2424), Wuhan, Hubei
The Second Xiangya Hospital of Central South University-Oncology ( Site 2418), Changsha, Hunan
First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 2402), Huai'an, Jiangsu
Northern Jiangsu People's Hospital-General Surgery Department ( Site 2403), Yangzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University-Oncology Department ( Site 2405), Nanchang, Jiangxi
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 2404), Nanchang, Jiangxi
Jilin Province Tumor Hospital-GCP office ( Site 2413), Changchun, Jilin
The First Hospital of Jilin University-Oncology ( Site 2414), Changchun, Jilin
Shanghai East Hospital ( Site 2428), Shanghai, Shanghai
Shanghai Pulmonary Hospital ( Site 2427), Shanghai, Shanghai
West China Hospital, Sichuan University ( Site 2422), Cheng Du, Sichuan
Sichuan Cancer hospital. ( Site 2421), Chengdu, Sichuan
The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 2425), Urumqi, Xinjiang
The first Affiliated Hospital, Zhejiang University School of Medicine-Respiratory Department ( Site 2406), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 2407), Hangzhou, Zhejiang
Zhejiang Cancer Hospital-Breast Oncology ( Site 2408), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 2430), Taizhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 2409), Wenzhou, Zhejiang
Centro Cancerológico del Caribe (CECAC) ( Site 0509), Barranquilla, Atlantico
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0501), Valledupar, Cesar
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0500), Bogota, Distrito Capital De Bogota
Oncologos del Occidente ( Site 0504), Pereira., Risaralda
Fundación Valle del Lili-Oncology CIC ( Site 0505), Cali, Valle Del Cauca
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0800), Brno, Brno-mesto
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 0803), Ostrava-Vitkovice, Ostrava Mesto
Fakultni nemocnice Olomouc-Klinika plicnich nemoci a tuberkulozy ( Site 0802), Olomouc, Not set
Clinique Clairval ( Site 0904), Marseille, Bouches-du-Rhone
Hôpital Robert Schuman ( Site 0907), Vantoux, Lorraine
Institut de Cancérologie de l'Ouest ( Site 0908), ANGERS cedex 02, Maine-et-Loire
Sainte Catherine Institut du Cancer Avignon Provence ( Site 0902), Avignon, Vaucluse
CHD Vendee ( Site 0901), La Roche-sur-Yon, Vendee
Hôpital Saint-Louis ( Site 0906), Paris, Not set
GEFOS Gesellschaft f. onkologische Studien ( Site 1005), Dortmund, Nordrhein-Westfalen
Universitätsklinikum Schleswig-Holstein-Pneumologie ( Site 1000), Luebeck, Schleswig-Holstein
SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1006), Gera, Thuringen
Charité Campus Virchow-Klinikum-Department of Infectious Diseases and Pulmonary Medicine ( Site 1003), Berlin, Not set
Bacs-Kiskun Varmegyei Oktatokorhaz ( Site 1100), Kecskemét, Bacs-Kiskun
Petz Aladar Egyetemi Oktato Korhaz ( Site 1101), Gyor, Gyor-Moson-Sopron
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 1103), Szolnok, Jasz-Nagykun-Szolnok
Reformatus Pulmonologiai Centrum ( Site 1102), Torokbalint, Pest
Zala Megyei Szent Rafael Kórház ( Site 1110), Zalaegerszeg, Zala
Országos Korányi Pulmonológiai Intézet ( Site 1104), Budapest, Not set
St. James's Hospital ( Site 1200), Dublin, Not set
Rambam Health Care Campus-Oncology Division ( Site 1302), Haifa, Not set
Shaare Zedek Medical Center ( Site 1300), Jerusalem, Not set
Rabin Medical Center ( Site 1303), Petah Tikva, Not set
Sheba Medical Center ( Site 1301), Ramat Gan, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1401), Napoli, Campania
Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 1409), Roma, Lazio
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1404), Milan, Lombardia
Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 1412), Monza, Lombardia
Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1408), Rozzano, Milano
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1402), Rome, Roma
Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1414), Brescia, Not set
Ospedale San Martino ( Site 1407), Genova, Not set
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 1410), Pavia, Not set
Ospedale di Circolo e Fondazione Macchi Varese-Oncology ( Site 1413), Varese, Not set
Aichi Cancer Center ( Site 2502), Nagoya, Aichi
Nagoya University Hospital ( Site 2519), Nagoya, Aichi
Fujita Health University Hospital ( Site 2515), Toyoake, Aichi
Hirosaki University Hospital ( Site 2514), Hirosaki, Aomori
Ehime University Hospital ( Site 2511), Toon, Ehime
Gunma Prefectural Cancer Center ( Site 2510), Ota, Gunma
Takarazuka City Hospital ( Site 2508), Takarazuka, Hyogo
Kanazawa University Hospital ( Site 2513), Kanazawa, Ishikawa
St. Marianna University Hospital ( Site 2521), Kawasaki, Kanagawa
Kanagawa Cardiovascular and Respiratory Center ( Site 2518), Yokohama, Kanagawa
Kanagawa Cancer Center ( Site 2504), Yokohama, Kanagawa
Matsusaka Municipal Hospital ( Site 2522), Matsusaka, Mie
Sendai Kousei Hospital ( Site 2507), Sendai, Miyagi
Kansai Medical University Hospital ( Site 2503), Hirakata, Osaka
Saitama Prefectural Cancer Center ( Site 2512), Kitaadachi-gun, Saitama
Cancer Institute Hospital of JFCR ( Site 2500), Koto, Tokyo
Toho University Omori Medical Center ( Site 2520), Ota, Tokyo
National Center for Global Health and Medicine ( Site 2516), Shinjuku, Tokyo
National Hospital Organization Yamaguchi Ube Medical Center ( Site 2523), Ube, Yamaguchi
Chiba University Hospital ( Site 2517), Chiba, Not set
National Hospital Organization Kyushu Medical Center ( Site 2509), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 2505), Niigata, Not set
Osaka International Cancer Institute ( Site 2506), Osaka, Not set
The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 2106), Bupyeong-gu, Incheon
Pusan National University Yangsan Hospital ( Site 2104), Yangsan-si, Kyongsangnam-do
Pusan National University Hospital ( Site 2100), Busan, Pusan-Kwangyokshi
Kyungpook National University Chilgok Hospital-Pulmonology ( Site 2102), Deagu, Taegu-Kwangyokshi
Chungnam national university hospital-Department of Internal Medicine ( Site 2107), Daejeon, Taejon-Kwangyokshi
Kyung Hee University Hospital ( Site 2101), Seoul, Not set
Asan Medical Center ( Site 2105), Seoul, Not set
Korea University Guro Hospital-Internal Medicine ( Site 2103), Seoul, Not set
Clínicas AUNA Sede Chiclayo ( Site 0604), Chiclayo, Lambayeque
Oncosalud-Clinical Research ( Site 0600), Lima, Not set
Hospital Militar Central Coronel Luis Arias Schereiber ( Site 0602), Lima, Not set
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 1510), Poznań, Dolnoslaskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1503), Bydgoszcz, Kujawsko-pomorskie
Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1513), Grudziadz, Kujawsko-pomorskie
Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1507), Gorlice, Malopolskie
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1515), Kraków, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1500), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1501), Przemysl, Podkarpackie
Szpital Wojewódzki w Koszalinie. ( Site 1517), Poland, Zachodniopomorskie
Centrul Medical Medicover Victoria ( Site 2000), Bucharest, Bucuresti
Cardiomed SRL Cluj-Napoca ( Site 2002), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2001), Florești, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2004), Craiova, Dolj
Cabinet Medical Oncomed ( Site 2005), Timisoara, Timis
SC ONCO CARD SRL ( Site 2007), Brasov, Not set
Clinica Polisano ( Site 2008), Sibiu, Not set
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 1703), Santiago de Compostela, Galicia
Hospital Insular de Gran Canaria-Oncology ( Site 1701), Las Palmas de Gran Canaria, Las Palmas
Hospital Quirón Málaga ( Site 1704), Málaga, Malaga
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1700), Barcelona, Not set
Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 1702), Madrid, Not set
Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 1705), Sevilla, Not set
National Taiwan University Cancer Center (NTUCC) ( Site 2209), Taipei City, Taipei
Taoyuan General Hospital ( Site 2203), Taoyuan City, Taoyuan
Chang Gung Memorial Hospital at Kaohsiung ( Site 2207), Kaohsiung, Not set
Taichung Veterans General Hospital ( Site 2204), Taichung, Not set
National Cheng Kung University Hospital ( Site 2205), Tainan, Not set
National Taiwan University Hospital-Oncology ( Site 2208), Taipei, Not set
Mackay Memorial Hospital-Chest Medicine ( Site 2201), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 2202), Taoyuan, Not set
Prapokklao Hospital ( Site 2306), Mueang, Chanthaburi
Faculty of Medicine - Khon Kaen University ( Site 2305), Muang, Khon Kaen
Faculty of Medicine Siriraj Hospital ( Site 2301), Bangkok, Krung Thep Maha Nakhon
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 2300), Dusit, Krung Thep Maha Nakhon
Lampang Cancer Hospital ( Site 2304), Mueang Lampang, Lampang
Songklanagarind hospital ( Site 2303), HatYai, Songkhla
Maharaj Nakorn Chiang Mai Hospital ( Site 2302), Chiang Mai, Not set
Medipol Mega Universite Hastanesi-oncology ( Site 1811), Stanbul, Istanbul
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1801), Ankara, Not set
Gazi Universitesi-Oncology ( Site 1804), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1800), Ankara, Not set
Memorial Kayseri Hastanesi ( Site 1805), Kayseri, Not set
Mersin Sehir Eğitim ve Araştırma Hastanesi-Oncology ( Site 1808), Mersin, Not set
Samsun Medical Park Hastanesi-medical oncology ( Site 1806), Samsun, Not set
Burjeel Medical City ( Site 2600), Abu Dhabi, Abu Zaby
Torbay Hospital ( Site 1906), Torquay, Devon
St Bartholomew's Hospital ( Site 1901), London, London, City Of
City Hospital, Nottingham University Hospitals NHS Trust-NCCTT ( Site 1911), Nottingham, Nottinghamshire
Conditions: Non-small Cell Lung Cancer, NSCLC
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