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All Clinical Trials in Canada
A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)
Recruiting
The purpose of this study is to compare pembrolizumab (MK-3475) in combination with sacituzumab govitecan with pembrolizumab alone with respect to progression-free survival (PFS) and overall survival (OS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by blinded independent central review (BICR) among adults with metastatic non-small cell lung cancer (NSCLC) with programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%).
The purpose of this study is to compare pembrolizumab (MK-3475) in combination with sacituzumab govitecan with pembrolizumab alone with respect to progression-free survival (PFS) and overall survival (OS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by blinded independent central review (BICR) among adults with metastatic non-small cell lung cancer (NSCLC) with programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Infirmary Cancer Care ( Site 0418), Mobile, Alabama +177 locations
Infirmary Cancer Care ( Site 0418), Mobile, Alabama
Clermont Oncology Center ( Site 0421), Clermont, Florida
University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0417), Miami, Florida
Mid Florida Hematology and Oncology Center ( Site 0416), Orange City, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0407), Marietta, Georgia
Our Lady of the Lake RMC ( Site 0424), Baton Rouge, Louisiana
Henry Ford Hospital ( Site 0412), Detroit, Michigan
Profound Research LLC ( Site 0440), Farmington Hills, Michigan
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0425), Minneapolis, Minnesota
Basil Clinical ( Site 0441), Inwood, New York
White Plains Hospital-Center for Cancer Care ( Site 0403), White Plains, New York
Kaiser Permanente Northwest-Central Interstate--Oncology ( Site 0408), Portland, Oregon
Oregon Health & Science University ( Site 0427), Portland, Oregon
Houston Methodist Hospital ( Site 0419), Houston, Texas
Central Texas Veterans health care ( Site 0414), Temple, Texas
Orange Hospital-Clinical Trials Unit ( Site 0600), Orange, New South Wales
Cancer Research SA-St Andrews Hospital ( Site 0603), Adelaide, South Australia
Frankston Hospital-Oncology and Haematology ( Site 0601), Frankston, Victoria
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0320), Fortaleza, Ceara
Hospital Tacchini ( Site 0322), Bento Goncalves, Rio Grande Do Sul
Hospital da Cidade de Passo Fundo ( Site 0321), Passo Fundo, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 0317), Santa Cruz do Sul, Rio Grande Do Sul
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0318), Barretos, Sao Paulo
A. C. Camargo Cancer Center ( Site 0324), Sao Paulo, Not set
BC Cancer Abbotsford-Medical Oncology ( Site 0433), Abbotsford, British Columbia
Southlake Regional Health Centre-Oncology Clinical Trials ( Site 0435), Newmarket, Ontario
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0430), Greenfield Park, Quebec
St. Marys Hospital Center-Oncology ( Site 0434), Montreal, Quebec
Centre integre universitaire de sante et de services sociaux-oncology ( Site 0431), Trois-Rivières, Quebec
Oncovida ( Site 0334), Santiago., Region M. De Santiago
Pontificia Universidad Catolica de Chile ( Site 0332), Santiago, Region M. De Santiago
Second Affiliated hospital of Anhui Medical University ( Site 0126), Hefei, Anhui
Anhui Provincial Hospital ( Site 0136), Hefei, Anhui
Beijing Cancer hospital ( Site 0104), Beijing, Beijing
Beijing Peking Union Medical College Hospital-pneumology department ( Site 0106), Beijing, Beijing
Beijing Chest Hospital,Capital Medical University ( Site 0105), Beijing, Beijing
Chongqing University Cancer Hospital-Medical Oncology ( Site 0130), Chongqing, Chongqing
Fujian Provincial Cancer Hospital ( Site 0131), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University ( Site 0132), Xiamen, Fujian
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 0125), Guangzhou, Guangdong
Affiliated Cancer Hospital of Guangxi Medical University ( Site 0113), Nanning, Guangxi
Harbin Medical University Cancer Hospital ( Site 0119), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 0127), Zhengzhou, Henan
Tongji Hospital Tongji Medical,Science & Technology ( Site 0116), Wuhan, Hubei
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0115), Wuhan, Hubei
Hubei Cancer Hospital ( Site 0107), Wuhan, Hubei
Xiangya Hospital Central South University ( Site 0124), Changsha, Hunan
The Second Xiangya Hospital of Central South University ( Site 0135), Changsha, Hunan
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 0112), Nanjing, Jiangsu
Nantong Tumor Hospital-Medical Oncology ( Site 0122), Nantong, Jiangsu
The First Affliated Hospital of Suzhou University ( Site 0114), Suzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University ( Site 0134), Nanchang, Jiangxi
The First Hospital of Jilin University ( Site 0117), Changchun, Jilin
Jilin Province Tumor Hospital-clinical research ( Site 0118), Changchun, Jilin
The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 0133), Xi'an, Shaanxi
Jinan Central Hospital-oncology department ( Site 0121), Jinan, Shandong
LinYi Cancer Hospital ( Site 0120), Linyi, Shandong
Shanghai Chest Hospital ( Site 0101), Shanghai, Shanghai
Fudan University Shanghai Cancer Center-Oncology ( Site 0102), Shanghai, Shanghai
Huashan Hospital, Fudan University ( Site 0103), Shanghai, Shanghai
West China Hospital of Sichuan University ( Site 0129), Cheng Du, Sichuan
Sichuan Cancer hospital. ( Site 0128), Chengdu, Sichuan
The First Affiliated Hospital, Zhejiang University ( Site 0109), Hangzhou, Zhejiang
The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0110), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital-Medical Oncology ( Site 0111), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 0108), Hangzhou, Zhejiang
North Estonia Medical Centre Foundation-Chemotherapy ( Site 0621), Tallinn, Harjumaa
Tartu University Hospital-Radiotherapy and oncology ( Site 0620), Tartu, Tartumaa
Universitätsmedizin Mannheim ( Site 0654), Mannheim, Baden-Wurttemberg
Klinikum Kempten ( Site 0655), Kempten, Bayern
Klinikum Würzburg Mitte ( Site 0651), Wuerzburg, Bayern
Katholisches Klinikum Koblenz ( Site 0650), Koblenz, Rheinland-Pfalz
Krankenhaus Martha-Maria Halle-Dölau-Klinik für Innere Medizin II ( Site 0657), Halle, Sachsen-Anhalt
Vivantes Hospital Spandau-Klinik für Innere Medizin, Hämatologie, Onkologie und Gastroenterologie- ( Site 0656), Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf-Lungenklinik Heckeshorn ( Site 0653), Berlin, Not set
Errikos Dunant Hospital Center-Fourth Department of Oncology and Clinical Trials Unit ( Site 0141), Athens, Attiki
Sotiria Thoracic Diseases Hospital of Athens-3rd Dept of Internal Medicine, Oncology Unit ( Site 0140), Athens, Attiki
European Interbalkan Medical Center-Oncology Department ( Site 0142), Thessaloniki, Not set
Shaare Zedek Medical Center-Oncology ( Site 0176), Jerusalem, Not set
Meir Medical Center-oncology ( Site 0171), KfarSaba, Not set
Rabin Medical Center-Oncology ( Site 0174), Petah Tikva, Not set
Sourasky Medical Center-Oncology ( Site 0175), Tel Aviv, Not set
Yitzhak Shamir Medical Center. ( Site 0179), Zerifin, Not set
Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 0677), Roma, Lazio
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII ( Site 0674), Bergamo, Lombardia
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0673), Milan, Lombardia
Azienda Ospedaliera Dei Colli-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 0671), Naples, Napoli
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 0675), Firenze, Toscana
Casa di Cura Dott. Pederzoli-LUNG-UNIT TORACIC ( Site 0670), Peschiera del Garda, Verona
Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 0676), Parma, Not set
Aichi Cancer Center ( Site 0018), Nagoya, Aichi
National Hospital Organization Shikoku Cancer Center ( Site 0008), Matsuyama, Ehime
Kurume University Hospital ( Site 0014), Kurume, Fukuoka
Takarazuka City Hospital ( Site 0015), Takarazuka, Hyogo
Kanazawa University Hospital ( Site 0019), Kanazawa, Ishikawa
Kanagawa Cancer Center ( Site 0016), Yokohama, Kanagawa
Miyagi Cancer Center ( Site 0001), Natori, Miyagi
Sendai Kousei Hospital ( Site 0012), Sendai, Miyagi
Niigata Cancer Center Hospital ( Site 0017), Niigata-shi, Niigata
Kurashiki Central Hospital ( Site 0011), Kurashiki, Okayama
Kansai Medical University Hospital ( Site 0005), Hirakata, Osaka
Kindai University Hospital ( Site 0013), Sayama, Osaka
Saitama Prefectural Cancer Center ( Site 0002), Kitaadachi-gun, Saitama
Shizuoka Cancer Center ( Site 0004), Nagaizumi-cho,Sunto-gun, Shizuoka
Tokyo Metropolitan Komagome Hospital ( Site 0020), Bunkyo ku, Tokyo
National Hospital Organization Kyushu Medical Center ( Site 0009), Fukuoka, Not set
Kyushu University Hospital ( Site 0010), Fukuoka, Not set
Okayama University Hospital ( Site 0007), Okayama, Not set
Nippon Medical School Hospital ( Site 0003), Tokyo, Not set
Wakayama Medical University Hospital ( Site 0006), Wakayama, Not set
Chonnam National University Hwasun Hospital-Pulmonology ( Site 0061), Hwasun, Jeonranamdo
Pusan National University Yangsan Hospital ( Site 0060), Pusan, Kyongsangnam-do
Chungnam national university hospital-Department of Internal Medicine ( Site 0063), Daejeon, Taejon-Kwangyokshi
Asan Medical Center ( Site 0064), Seoul, Not set
Korea University Guro Hospital-Internal Medicine ( Site 0062), Seoul, Not set
Daugavpils Regional Hospital-Oncology Department ( Site 0194), Daugavpils, Daugavpils Novads
Liepjas reionl slimnca ( Site 0191), Liepaja, Not set
Pauls Stradins Clinical Univeristy Hospital-Chemotherapy department ( Site 0192), Riga, Not set
RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia-Out-patient and Day patient facility of Ch ( Site 0193), Riga, Not set
Hospital of Lithuanian University of Health Sciences Kauno klinikos-Pulmonology ( Site 0692), Kaunas, Kauno Apskritis
National Cancer Institute-Department of Thoracic Surgery and Oncology ( Site 0691), Vilnius, Vilniaus Miestas
Hospital Raja Perempuan Zainab II-Medical Department ( Site 0035), Kota Bharu, Kelantan
Hospital Pulau Pinang-Oncology, radiotherapy and palliat ( Site 0034), George Town, Pulau Pinang
Beacon Hospital Sdn Bhd ( Site 0033), Petaling Jaya, Selangor
COI Tijuana - Centro Oncológico Internacional ( Site 0350), Tijuana, Baja California
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0352), Monterrey, Nuevo Leon
Medical Care and Research SA de CV ( Site 0353), Merida, Yucatan
Centro de Investigacion Medica Aguascalientes ( Site 0340), Aguascalientes, Not set
Oaxaca Site Management Organization ( Site 0346), Oaxaca, Not set
Centro de Investigacion Clinica de Oaxaca ( Site 0351), Oaxaca, Not set
Clinica Vallesur - AUNA ( Site 0360), Arequipa, Ariqipa
Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 0362), Concepcion, Junin
Centro de investigacion Clínica Trujillo ( Site 0358), Trujillo, La Libertad
Detecta Clínica ( Site 0364), Surquillo, Lima
Clínica Internacional - Sede San Borja ( Site 0356), Lima, Not set
Instituto Neuro Cardiovascular de las Americas ( Site 0365), Lima, Not set
Hospital Cayetano Heredia ( Site 0361), Lima, Not set
Metro Davao Medical and Research Center ( Site 0047), Davao City, Davao Del Sur
ST. LUKE'S MEDICAL CENTER ( Site 0046), Quezon City, National Capital Region
Cebu Doctors University Hospital ( Site 0045), Cebu, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 0208), Bydgoszcz, Kujawsko-pomorskie
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 0201), Siedlce, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 0200), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 0203), Przemysl, Podkarpackie
Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 0202), Prabuty, Pomorskie
Szpital Rejonowy im. dr. J. Rostka w Raciborzu ( Site 0207), Racibórz, Slaskie
Med-Polonia Sp. z o. o. ( Site 0204), Poznan, Wielkopolskie
Gral Medical SRL-Medical Oncology ( Site 0220), București, Bucuresti
Cardiomed SRL Cluj-Napoca ( Site 0217), Cluj-Napoca, Cluj
Amethyst Radiotherapy Center-Oncologie Medicala ( Site 0216), Florești, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 0215), Craiova, Dolj
Cabinet Medical Oncomed ( Site 0219), Timisoara, Timis
Institutul Oncologic-Oncologie Medicala ( Site 0218), Cluj, Not set
Chung Shan Medical University Hospital ( Site 0078), Taichung City, Taichung
National Taiwan University Cancer Center (NTUCC) ( Site 0079), Taipei City, Taipei
E-Da hospital ( Site 0075), Kaohsiung, Not set
China Medical University Hospital-Internal Medicine ( Site 0083), Taichung, Not set
National Cheng Kung University Hospital-Clinical Trial Center ( Site 0076), Tainan, Not set
National Taiwan University Hospital-Internal Medicine ( Site 0080), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch ( Site 0082), Taoyuan, Not set
Maharaj Nakorn Chiang Mai Hospital ( Site 0092), Muang, Chiang Mai
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 0097), Bangkok, Krung Thep Maha Nakhon
Faculty of Medicine Siriraj Hospital ( Site 0090), Bangkok, Krung Thep Maha Nakhon
Lampang Cancer Hospital ( Site 0098), Mueang Lampang, Lampang
Songklanagarind hospital ( Site 0091), HatYai, Songkhla
Sunpasitthiprasong Hospital ( Site 0093), Ubon Ratchathani, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 0265), Ankara, Not set
Liv Hospital Ankara-Oncology ( Site 0274), Ankara, Not set
Ankara City Hospital-Medical Oncology ( Site 0268), Ankara, Not set
Trakya University-Medical Oncology ( Site 0270), Edirne, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0267), Istanbul, Not set
VM Medical Park Pendik Hospital ( Site 0271), Istanbul, Not set
I.E.U. Medical Point Hastanesi-Oncology ( Site 0266), Izmir, Not set
Mersin Sehir Eğitim ve Araştırma Hastanesi ( Site 0275), Mersin, Not set
Leicester Royal Infirmary-HOPE Clinical Trials Unit ( Site 0300), Leicester, Leicestershire
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 0302), London, London, City Of
University College London Hospital ( Site 0305), London, London, City Of
The Clatterbridge Cancer Centre ( Site 0303), Wirral, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
Recruiting
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessme... Read More
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessments, leukapheresis and the Pretreatment evaluation;
* Treatment, which starts with the administration of lymphodepleting (LD) chemotherapy and continues through JCAR017 administration at Day 1 with follow-up through Day 29;
* Posttreatment, which includes follow-up assessments for disease status and safety for 5 years. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: UCLA Medical Centre-Santa Monica, Santa Monica, California +58 locations
UCLA Medical Centre-Santa Monica, Santa Monica, California
University Of Colorado Cancer Center, Aurora, Colorado
Yale Cancer Center, New Haven, Connecticut
Local Institution - 0601, Hollywood, Florida
Washington University School Of Medicine, Miami, Florida
Northwestern University, Chicago, Illinois
Local Institution - 109, Niles, Illinois
University Of Iowa, Iowa City, Iowa
Cancer Center of Kansas, Wichita, Kansas
University of Maryland - Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Massachusetts General Hospital - Dana-Farber Cancer Institute, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Karmanos Cancer Center, Detroit, Michigan
Local Institution - 118, Detroit, Michigan
Atlantic Health System Morristown Medical Center, Morristown, New Jersey
Memorial Sloan Kettering Cancer Center, New York, New York
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Local Institution - 120, Fargo, North Dakota
Cleveland Clinic Foundation, Cleveland, Ohio
Providence Cancer Center/Earle A. Chiles Res. Inst., Portland, Oregon
University of Pennsylvania - Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania
Local Institution - 126, Pittsburgh, Pennsylvania
Local Institution - 113, Sioux Falls, South Dakota
Local Institution - 125, Knoxville, Tennessee
Texas Oncology, Dallas, Texas
Houston Methodist Hospital, Houston, Texas
The University of Texas - MD Anderson Cancer Center, Houston, Texas
University Of Virginia Health System, Charlottesville, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
Allgemeinen Krankenhaus (AKH) Wien - Medizinische Universitaet Wien, Wien, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
Hopital Maisonneuve - Rosemont, Montreal, Quebec
CHRU-Hopital Claude Huriez, Lille, Not set
CHU Montpellier - Hôpital Saint Eloi, Montpellier CEDEX 5, Not set
Hopital Saint Louis, Paris Cedex 10, Not set
Centre Hospitalier Lyon-Sud, Pierre-Benite CEDEX, Not set
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes Cedex 02, Not set
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse, Not set
Universitaetsklinikum Ulm, Ulm, Baden-Wurttemberg
Universitätsklinikum Regensburg, Regensburg, Bayern
Local Institution - 506, Berlin, Not set
Local Institution - 503, Karlsruhe, Not set
Local Institution - 505, Kiel, Not set
University Hospital Cologne, Köln, Not set
LMU Klinikum der Universitat Munchen, Munich, Not set
Azienda Ospedaliera Papa Giovanni Xxiii, Bergamo, Not set
Local Institution - 302, Bologna, Not set
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale, Naples, Not set
Local Institution - 553, Sapporo-shi, Hokkaido
Local Institution - 550, Chuo-ku, Tokyo
Local Institution - 551, Minato-ku, Tokyo
Local Institution - 552, Fukuoka, Not set
Local Institution - 352, Barcelona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Virgen Del Rocio, Sevilla, Not set
Karolinska Hospital, Stockholm, Not set
University College London Hospitals NHS Foundation Trust - University College Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Conditions: Lymphoma, Non-Hodgkin
A Study to Compare the Results of FGFR Testing by Either ctDNA Blood Testing or Standard Tumor Tissue Testing
Recruiting
A new drug, erdafitinib, became available for some patients with bladder cancer that has spread to other organs. To qualify, patients must have specific genetic changes in their tumors. Currently, doctors use tumor tissue samples to check for these genetic changes, but these samples might not accurately reflect the current state of the patient's cancer.
In this study, Investigators will test the patient's blood for these genetic changes in addition to the tumor tissue samples. It is thought tha... Read More
A new drug, erdafitinib, became available for some patients with bladder cancer that has spread to other organs. To qualify, patients must have specific genetic changes in their tumors. Currently, doctors use tumor tissue samples to check for these genetic changes, but these samples might not accurately reflect the current state of the patient's cancer.
In this study, Investigators will test the patient's blood for these genetic changes in addition to the tumor tissue samples. It is thought that the blood test will give a more accurate result.
Investigators hope this study will help to find out if more patients can benefit from erdafitinib than the ones identified by tissue testing only. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Arthur J.E Child Comprehensive Cancer Centre, Calgary, Alberta +6 locations
Arthur J.E Child Comprehensive Cancer Centre, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
BC Cancer Agency, Vancouver, British Columbia
London Health Sciences Centre, London, Ontario
Ottawa Hospital Research Institute, Ottawa, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
CHU de Québec-Université Laval, Québec City, Quebec
Conditions: Metastatic Bladder Cancer, Metastatic Urothelial Carcinoma
A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia
Recruiting
The purpose of the study is to evaluate the efficacy and safety of luspatercept plus best supportive care (BSC) vs placebo plus BSC on anemia in adult participants with α-thalassemia hemoglobin H (HbH) disease and determine the safety and drug levels in adolescent participants.
The purpose of the study is to evaluate the efficacy and safety of luspatercept plus best supportive care (BSC) vs placebo plus BSC on anemia in adult participants with α-thalassemia hemoglobin H (HbH) disease and determine the safety and drug levels in adolescent participants. Read Less
Gender:
ALL
Ages:
12 years and above
Trial Updated:
08/19/2025
Locations: Local Institution - 0008, Halifax, Nova Scotia +35 locations
Local Institution - 0008, Halifax, Nova Scotia
The First People's Hospital of Foshan, Foshan, Guangdong
Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong
Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong
Maoming People's Hospital, Maoming Shi, Guangdong
Shenzhen Second People's Hospital, Shenzhen Shi, Guangdong
Liuzhou People's Hospital, Liuzhou, Guangxi
People's Liberation Army The 923rd Hospital, Nanning Shi, Guangxi
Local Institution - 0011, Haikou, Hainan
Local Institution - 0012, Kunming, Yunnan
Hainan General Hospital, Haikou, Not set
The First Affiliated Hospital of Guangxi Medical University, Nanning, Not set
Local Institution - 0005, Thessaloniki, B
Local Institution - 0007, Larissa, E
Local Institution - 0018, Rio, G
Local Institution - 0006, Athens, Not set
Local Institution - 0009, Goudi, Not set
Local Institution - 0025, Hong Kong, HK
Local Institution - 0024, Hong Kong Island, Not set
Local Institution - 0022, Cagliari, CA
Local Institution - 0026, Genova, GE
Local Institution - 0020, Orbassano, TO
Local Institution - 0028, Napoli, Not set
"Universita degli Studi della Campania ""Luigi Vanvitelli"" - AOU - Clinica Pediatrica", Napoli, Not set
Hospital Sultanah Aminah, Johor Bahru, Not set
Local Institution - 0032, Kuala Lumpur, Not set
Local Institution - 0035, Al-Ahsa, Not set
Local Institution - 0034, Riyadh, Not set
Local Institution - 0036, Singapore, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, KHH
National Taiwan University Hospital, Nan Gang Qu, TPE
China Medical University Hospital, Taichung, TXG
Siriraj Hospital, Bangkok, Not set
Local Institution - 0031, Mueang Phitsanulok, Not set
Local Institution - 0027, Altındağ, Not set
Local Institution - 0021, Topkapı, Not set
Conditions: Anemia
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Recruiting
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Chao Family Comprehensive Cancer Center, Orange, California +175 locations
Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute, Palo Alto, California
Scripps Prebys Cancer Center, San Diego, California
Rocky Mountain Cancer Centers (Williams) Usor, Aurora, Colorado
Yale University, Yale Cancer Center, New Haven, Connecticut
Eastern Connecticut Hematology and Oncology, Norwich, Connecticut
Cleveland Clinic Florida, Weston, Florida
Northwestern University, Chicago, Illinois
Illinois Cancer Specialists (Niles) Usor, Niles, Illinois
Mission Cancer and Blood, Waukee, Iowa
University of Louisville, Brown Cancer Center, Louisville, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Dana Farber Cancer Institute, Boston, Massachusetts
The Cancer and Hematology Centers, Grand Rapids, Michigan
Mayo Clinic Rochester, Rochester, Minnesota
Memorial Sloan Kettering Cancer Center Mskcc, New York, New York
Clinical Research Alliance, Inc, Westbury, New York
University of North Carolina At Chapel Hill, Chapel Hill, North Carolina
Levine Cancer Center, Charlotte, North Carolina
Oncology Hematology Care Clinical Trials, Llc, Cincinnati, Ohio
Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene, Oregon
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
Upmc Hillman Cancer Center(Univ of Pittsburgh), Pittsburgh, Pennsylvania
Tennessee Oncology, Nashville, Tennessee
Texas Oncology Baylorcharles A Sammons Cancer Center, Dallas, Texas
Ut Southwestern Medical Center, Dallas, Texas
Texas Oncology San Antonio Medical Center Usor, San Antonio, Texas
Texas Oncology Tyler, Tyler, Texas
Northwest Cancer Specialist, Pc(Us Oncology Research), Vancouver, Washington
Hospital Aleman, Caba, Not set
FUNDALEU, Caba, Not set
Instituto Alexander Fleming (Iaf), Ciudad Autonoma Buenos Aires, Not set
Blacktown Cancer and Haematology Centre, Blacktown, New South Wales
St George Hospital, Kogarah, New South Wales
Northern Nsw Health District, Lismore, New South Wales
Macquarie University, North Ryde, New South Wales
Genesiscare North Shore, St Leonards, New South Wales
Wollongong Private Hospital, Wollongong, New South Wales
Sunshine Coast Hospital and Health Service, Birtinya, Queensland
Princess Alexandra Hospital, Woolloongabba, Queensland
Monash Health, Clayton, Victoria
St Vincents Hospital Melbourne, Fitzroy, Victoria
Peter Maccallum Cancer Centre, Melbourne, Victoria
The Alfred Hospital, Melbourne, Victoria
Rockingham Hospital, Cooloongup, Western Australia
Perth Blood Institute, West Perth, Western Australia
Medizinische Universitatsklinik Innsbruck, Innsbruck, Not set
Medical University Vienna Oncology, Wien, Not set
Hanusch Krankenhaus, Wien, Not set
Cliniques Universitaires Saint Luc, Brussels, Not set
Uz Antwerpen, Edegem, Not set
University Hospitals Leuven, Leuven, Not set
CETUS, Belo Horizonte, Not set
Universidade de Campinas Centro de Hematologia E Hemoterapia, Campinas, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Complexo Hospitalar de Niteroi, Niteroi, Not set
Irmandade Da Santa Casa de Misericordia Hospital Porto Alegre, Porto Alegre, Not set
Hospital Sao Lucas, Rio de Janeiro, Not set
Instituto Dor de Pesquisa E Ensino Rio de Janeiro, Rio de Janeiro, Not set
Hospital Santa Izabel, Salvador, Not set
Hospital Samaritano Sao Paulo, Sao Paulo, Not set
Hospital Nove de Julho Dasa, Sao Paulo, Not set
Instituto Brasileiro de Controle Do Cancer, Sao Paulo, Not set
Instituto Dor de Pesquisa E Ensino Sao Paulo, Sao Paulo, Not set
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular, Sao Paulo, Not set
Hospital Santa Rita de Cassia Afecc, Vitoria, Not set
Cross Cancer Institute, Edmonton, Alberta
British Columbia Cancer Agency the Vancouver Centre, Vancouver, British Columbia
Cancercare Manitoba, Winnipeg, Manitoba
Newfoundland and Labrador Health Services, St Johns, Newfoundland and Labrador
The Ottawa Hospital, Ottawa, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Ciusss Nim Hscm, Montreal, Quebec
Arthur Je Child Comprehensive Cancer Centre, Calgary, Not set
China Japan Friendship Hospital, Beijing, Beijing
Fujian Provincial Hospital, Fuzhou, Fujian
Fujian Medical University Union Hospitalqishan Branch, Fuzhou, Fujian
The First Affiliated Hospital of Xiamen University, Xiamen, Fujian
Guangzhou First Peoples Hospital, Guangzhou, Guangdong
Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong
Guangxi Medical University Cancer Hospital Wuxiang Branch, Nanning, Guangxi
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia
Zhongda Hospital Southeast University, Nanjing, Jiangsu
Suzhou Municipal Hospitalbaita Branch, Suzhou, Jiangsu
Affiliated Hospital of Jiangnan University South Campus, Wuxi, Jiangsu
Northern Jiangsu Peoples Hospital, Yangzhou, Jiangsu
Jiangxi Cancer Hospital, Nanchang, Jiangxi
Liaoning Cancer Hospital and Institute, Shenyang, Liaoning
Shaanxi Provincial Peoples Hospital, Xian, Shaanxi
Shandong Provincial Hospital, Jinan, Shandong
Jining No Peoples Hospital West Branch, Jining, Shandong
The Affiliated Hospital of Qingdao University Branch West Coast, Qingdao, Shandong
Affiliated Zhongshan Hospital of Fudan University, Shanghai, Shanghai
West China Hospital, Sichuan University, Chengdu, Sichuan
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch, Tianjin, Tianjin
The Affiliated Peoples Hospital of Ningbo University, Ningbo, Zhejiang
Taizhou Hospital of Zhejiang Province (East), Taizhou, Zhejiang
Fakultni Nemocnice Brno, Brno, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Vseobecna Fakultni Nemocnice V Praze, Praha, Not set
Ustav Hematologie A Krevni Transfuze (Uhkt), Praha, Not set
University Hospital of Aalborg, Denmark, Aalborg, Not set
Rigshospitalet, Copenhagen, Not set
Odense University Hospital, Odense C, Not set
Zealand University Hospital, Roskilde, Roskilde, Not set
Chu Clermont Ferrand Therapie Cellulaire and Hematolo, Clermontferrand, Not set
Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes, Not set
Hopital de La Pitie Salpetriere, Paris, Not set
Chu Hopital Lyon Sud, PierreBenite, Not set
Hopital Robert Debre, Reims, Not set
Chu Rennes, Rennes Cedes, Not set
Centre Henri Becquerel, Rouen Cedex, Not set
Icans Institut de Cancerologie Strasbourg Europe, Strasbourg, Not set
Iuct Oncopole, Toulouse, Not set
Chu Nancy Hopital Brabois, VandoeuvrelesNancy, Not set
Osp Kurfuerstendamm, Berlin, Not set
Gokos Gmbh, Dresden, Not set
Universitatsklinikum Jena Klinik Fur Innere Medizin Ii, Jena, Not set
Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Not set
Uniklinik Koeln (Aoer), Koln, Not set
Klinikum Der Universitat Munchen Medizinische Klinik Und Poliklinik Iii, Munchen, Not set
Stauferklinikum Schwabisch Gmund Kliniken Ostalb, Mutlangen, Not set
Dietrich Bonhoeffer Klinikum Neubrandenburg, Neubrandenburg, Not set
Medizinische Universitaetsklinik, Tubingen, Not set
Universitaetsklinikum Ulm, Ulm, Not set
Haematologisch Onkologische Schwerpunktpraxis, Wurzburg, Not set
Mater Misericordiae University Hospital, Dublin, Not set
St Jamess Hospital, Dublin, Not set
University Hospital Galway, Galway, Not set
University Hospital Limerick, Limerick, Not set
Azienda Ospedaliera Policlinico Di Bari, Bari, Not set
Ao Brotzu Ospedale Oncologico Armando Businco, Cagliari, Not set
Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Catania, Not set
Azienda Ospedaliero Universitaria Di Ferrara, Ferrara, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set
Universita Degli Studi Di Modena Azienda Ospedaliere Policlinco, Modena, Not set
Asl Salerno Andrea Tortora, Pagani, Not set
Pusan National University Hospital, SeoGu, Busan Gwang'yeogsi
Seoul National University Bundang Hospital, BundangGu SeongnamSi, Gyeonggi-do
National Cancer Center (Korea), IlsandongGu GoyangSi, Gyeonggi-do
Samsung Medical Center, GangnamGu, Seoul Teugbyeolsi
The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi
Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Flevoziekenhuis, Almere, Not set
Rijnstate, Arnhem, Not set
Albert Schweitzer Ziekenhuis, Dordrecht, Not set
Tergooi Mc, Hilversum, Not set
North Shore Hospital, Auckland, Not set
Auckland City Hospital, Auckland, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz, Not set
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu, Torun, Not set
Centralny Szpital Kliniczny Uck Wum, Warszawa, Not set
Uniwersytecki Szpital Kliniczny Hematology, Wroclaw, Not set
Vall D Hebron Institute of Oncology Vhio, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Ico Lhospitalet Hospital Duran I Reynals, Lhospitalet de Llobregat, Not set
Hospital de La Princesa, Madrid, Not set
Hospital Universitario Infanta Leonor, Madrid, Not set
Costa Del Sol (Marbella, Malaga), Marbella, Not set
Hospital Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Hospital Virgen de Valme (Sevilla), Sevilla, Not set
Sahlgrenska University Hospital Hematology, Goteborg, Not set
Skanes Universitetssjukhus I Lund, Lund, Not set
Karolinska Universitetssjukhuset Solna, Stockholm, Not set
Uppsala Akademiska Sjukhus, Uppsala, Not set
University Hospitals Dorset Royal Bournemouth Hospital, Bournemouth, Not set
Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set
St Jamess University Hospital, Leeds, Not set
Kings College Hospital, London, Not set
Freeman Hospital, NewCastle Upon Tyne, Not set
Clatterbridge Cancer Centre, Wirral, Not set
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
Recruiting
Researchers are looking for a better way to treat men at high-risk of biochemical recurrence (BCR) of prostate cancer.
BCR means that in men who had prostate cancer and were treated by either surgery and/ or radiation therapy, the blood level of a specific protein called PSA rises. PSA is a marker of prostate cancer cells activity. The PSA increase means that the cancer has come back even though conventional imaging such as computed tomography (CT) scans, magnetic resonance imaging (MRI) and bo... Read More
Researchers are looking for a better way to treat men at high-risk of biochemical recurrence (BCR) of prostate cancer.
BCR means that in men who had prostate cancer and were treated by either surgery and/ or radiation therapy, the blood level of a specific protein called PSA rises. PSA is a marker of prostate cancer cells activity. The PSA increase means that the cancer has come back even though conventional imaging such as computed tomography (CT) scans, magnetic resonance imaging (MRI) and bone scans does not show any lesion of prostate cancer. Recently a more sensitive imaging method called prostate-specific membrane antigen \[PSMA\] positron emission tomography \[PET\]) /computed tomography \[CT\]) scan may identify prostate cancer lesions not detectable by conventional imaging. Men with BCR have a higher risk of their cancer spreading to other parts of the body, particularly when PSA levels raised to a certain limit within a short period of time after local therapies. Once the cancer spreads to other parts of the body, it can become even harder to treat.
In men with prostate cancer, male sex hormones (also called androgens) like testosterone can help the cancer grow and spread. To reduce androgens levels in these patients, there are treatments that block androgens production in the body called androgen deprivation therapy (ADT). ADT is often used to stop prostate cancer. Another way to stop prostate cancer growth and spread is to block the action of androgen receptors on prostate cancer cells called androgen receptor inhibitors (ARIs). The new generation ARIs including darolutamide can block the action of androgens receptors and are available for the treatment of prostate cancer in addition to ADT. It is already known that men with prostate cancer benefit from these treatments.
The main objective of this study is to learn if the combination of darolutamide and ADT prolongs the time that the participants live without their cancer getting worse, or to death due to any cause, compared to placebo (which is a treatment that looks like a medicine but does not have any medicine in it) and ADT given for a pre-specified duration of 24 months.
To do this, the study team will measure the time from the date of treatment allocation to the finding of new cancer spread in the participants by using PSMA PET/CT, or death due to any cause. The PSMA PET/CT scans is performed using a radioactive substance called a "tracer" that specifically binds to the prostate-specific membrane antigen (PSMA) which is a protein often found in large amounts on prostate cancer cells.
To avoid bias in treatment, the study participants will be randomly (by chance) allocated to one of two treatment groups. Based on the allocated treatment group, the participants will either take darolutamide plus ADT or placebo plus ADT twice daily as tablets by mouth. The study will consist of a test (screening) phase, a treatment phase and a follow-up phase. The treatment duration is pre-specified to be 24 months unless the cancer gets worse, the participants have medical problems, or they leave the study for any reason. In addition, image guided radiotherapy (IGRT) or surgery is allowed and your doctor will explain the benefits and risks of this type of therapy.
During the study, the study team will:
* take blood and urine samples.
* measure PSA and testosterone levels in the blood samples
* do physical examinations
* check the participants' overall health
* examine heart health using electrocardiogram (ECG)
* check vital signs
* check cancer status using PSMA PET/CT scans, CT, MRI and bone scans
* take tumor samples (if required)
* ask the participants if they have medical problems
About 30 days after the participants have taken their last treatment, the study doctors and their team will check the participants' health and if their cancer worsened. The study team will continue to check this and regularly ask the participants questions about medical problems and subsequent therapies until they leave the study for any reason or until they leave the study for any reason or until the end of the study, whatever comes first. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: City of Hope - Phoenix Cancer Center, Goodyear, Arizona +299 locations
City of Hope - Phoenix Cancer Center, Goodyear, Arizona
Mayo Clinic Hospital - Phoenix - Cardiology, Phoenix, Arizona
Arizona Institute of Urology, Tucson, Arizona
City of Hope - Duarte Cancer Center, Duarte, California
University of Southern California, Los Angeles, California
Tower Urology, Los Angeles, California
UCLA Clark Urology Center, Los Angeles, California
University of California Irvine Medical Center, Orange, California
UCSF Bakar Precision Cancer Medicine Building - Genitourinary, San Francisco, California
Colorado Urology - St. Anthony Hospital Campus, Lakewood, Colorado
Clermont Oncology Center, Clermont, Florida
University of Florida - Jacksonville, Jacksonville, Florida
Mid Florida Cancer Centers, Orange City, Florida
Northwestern Medicine - Urology, Chicago, Illinois
Jesse Brown VA Medical Center, Chicago, Illinois
Comprehensive Cancer Center, Chicago, Illinois
Urology of Indiana, LLC, Greenwood, Indiana
First Urology PSC, Jeffersonville, Indiana
The University of Kansas Cancer Center - Richard and Annette Bloch Radiation Oncology Pavilion, Kansas City, Kansas
Chesapeake Urology Associates - Towson, Baltimore, Maryland
Sidney Kimmel Comprehensive Cancer Center - Johns Hopkins, Baltimore, Maryland
Dana-Farber Cancer Institute - Oncology Department, Boston, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
Barbara Ann Karmanos Cancer Institute - Detroit Headquarters, Detroit, Michigan
Michigan Institute of Urology - Troy - Town Center Building, Troy, Michigan
M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center, Minneapolis, Minnesota
Washington University School of Medicine - Center for Advanced Medicine (CAM), Saint Louis, Missouri
Urology Cancer Center, PC, Omaha, Nebraska
New Jersey Urology (NJU), Saddle Brook, New Jersey
New Jersey Urology - Voorhees, Voorhees, New Jersey
NYU Langone Health, Mineola, New York
Icahn School of Medicine at Mount Sinai - Oncology, New York, New York
Associated Medical Professionals of NY, PLLC, Syracuse, New York
White Plains Hospital, White Plains, New York
Alliance Urology Specialists, Greensboro, North Carolina
Wake Forest Baptist Health, Winston-Salem, North Carolina
The Urology Group - Norwood Surgery Center, Cincinnati, Ohio
Ohio State University Wexner Medical Center, Columbus, Ohio
MidLantic Urology - Bala Cynwyd, Bala-Cynwyd, Pennsylvania
Urological Associates of Lancaster, Lancaster, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh, Pittsburgh, Pennsylvania
VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania
Bon Secours St. Francis Hospital, Greenville, South Carolina
Carolina Urological Research Center, Myrtle Beach, South Carolina
Urology Austin, PLLC (an affiliate of Urology America), Austin, Texas
University of Texas Southwestern Medical Center-Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas
University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston, Texas
Urology San Antonio, PA dba USA Clinical Trials, San Antonio, Texas
The Urology Place, San Antonio, Texas
Spokane Urology PS, Spokane, Washington
Blacktown Hospital, Blacktown, New South Wales
Chris O'Brien Lifehouse, Camperdown, New South Wales
University of New South Wales (UNSW) - Liverpool Hospital - Liverpool Cancer Therapy Centre, Liverpool, New South Wales
GenesisCare Newcastle, Newcastle, New South Wales
Port Macquarie Base Hospital, Port Macquarie, New South Wales
St Vincents Hospital Sydney, Sydney, New South Wales
Prince of Wales Hospital NSW, Sydney, New South Wales
Macquarie University Hospital, Sydney, New South Wales
Sydney Adventist Hospital, Wahroonga, New South Wales
Westmead Hospital, Westmead, New South Wales
Royal Brisbane & Women's Hospital, Brisbane, Queensland
Bundaberg Hospital, Genesis Cancer Care - Bundaberg, Bundaberg, Queensland
Wide Bay Hospital and Health Service - Hervey Bay Hospital, Pialba, Queensland
Tasman Health Care, Southport, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Eastern Clinical Research Unit - Box Hill, Box Hill, Victoria
Epworth HealthCare, East Melbourne, Victoria
Northern Hospital, Epping, Victoria
Barwon Health, Geelong, Victoria
Austin Health, Heidelberg, Victoria
Cabrini Malvern, Malvern, Victoria
Western Urology, Maribyrnong, Victoria
Australian Prostate Centre, North Melbourne, Victoria
Royal Melbourne Hospital, Parkville, Victoria
Sir Charles Gairdner Hospital, Nedlands, Western Australia
Ordensklinikum Linz GmbH Elisabethinen, Linz, Oberösterreich
Medizinische Universität Innsbruck, Innsbruck, Tirol
Krankenhaus der Barmherzigen Brüder, Vienna, Wien
Medizinische Universitaet Graz - Klinische Abteilung für Onkologie - Innere Medizin, Graz, Not set
Uniklinikum Salzburg - Landeskrankenhaus, Salzburg, Not set
Medizinische Universität Wien- Universitätsklinik für Urologie, Wien, Not set
Institut Jules Bordet/Jules Bordet Instituut, Bruxelles, Not set
Maria Middelares General Hospital | Medical Oncology Department, Gent, Not set
UZ Gent - department Urology, Gent, Not set
Jessa Hospital | Campus Virga Jesse - Data Management Oncology and Hematology Department, Hasselt, Not set
AZ Groeninge Campus Kennedylaan - Urology, Kortrijk, Not set
Hopital de La Louvière - Site Jolimont - Oncology department, La Louvière, Not set
Universitair Ziekenhuis Leuven | Gasthuisberg Campus - Urology Department, Leuven, Not set
Hospital São Rafael, Salvador, Bahia
Assistência Multidisciplinar em Oncologia (AMO), Salvador, Bahia
Oncocentro - Fortaleza, Fortaleza, Ceará
Hospital Evangélico de Cachoeiro de Itapemirim, Vitória, Espírito Santo
Liga Paranaense de Combate ao Cancer-Hosp Erasto Gaertner, Curitiba, Parana
Real Hospital Português, Recife, Pernambuco
Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica, Natal, Rio Grande Do Norte
Hospital Moinhos de Vento-Centro Clínico, Porto Alegre, Rio Grande Do Sul
Hospital Mae de Deus, Porto Alegre, Rio Grande Do Sul
Instituto D'Or Pesquisa e Ensino (IDOR) (D'Or Institute for Research & Education) - Rio de Janeiro, Rio de Janeiro, RJ
Faculdade de Medicina do ABC, Santo André, Sao Paulo
Instituto do Cancer do Estado de Sao Paulo, São Paulo, Sao Paulo
Real e Benemérita Associação Portuguesa de Beneficência, São Paulo, Sao Paulo
Inst. de Assistência Médica ao Sérvidor Público Estadual, São Paulo, Sao Paulo
Hospital das Clínicas da Universidade de Campinas - UNICAMP, São Paulo, Sao Paulo
NAIC - Instituto do Cancer, Bauru, Not set
Hospital Sirio Libanês - Hospital Base de Brasilia, Brasilia, Not set
Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Not set
Hospital Sirio Libanes, Sao Paulo, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
Hospital do Cancer de Sao Paulo - A. C. Camargo, Sao Paulo, Not set
Hospital Israelita Albert Einstein | Morumbi - Clinical Research Department, Sao Paulo, Not set
Prostate Cancer Centre, Calgary, Alberta
Kaye Edmonton Clinic - Dianne and Irving Kipnes Urology Centre, Edmonton, Alberta
Vancouver Prostate Centre, Vancouver, British Columbia
BC Cancer - Victoria, Victoria, British Columbia
Nova Scotia Health Authority, Halifax, Nova Scotia
St. Joseph's Healthcare - Hamilton, Hamilton, Ontario
London Health Sciences Centre (LHSC) - London Regional Cancer Program (LRCP), London, Ontario
Princess Margaret Cancer Centre - Oncology Department, Toronto, Ontario
CISSS de l'Outaouais - Hopital de Gatineau - Centre de cancerolgie, Gatineau, Quebec
Urology South Shore Research - Research Department, Greenfield Park, Quebec
Hopital Maisonneuve-Rosemont, Montreal, Quebec
Sir Mortimer B. Davis Jewish General Hospital - Radiation Oncology, Montreal, Quebec
Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-Centre-du-Quebec - Radio-oncologie, Trois-rivieres, Quebec
BC Cancer - Abbotsford, Abbotsford, Not set
Hôtel-Dieu de Lévis - Urology, Quebec, Not set
Centre Hospitalier Universitaire de Sherbrooke (CHUS) - Hopital Fleurimont, Sherbrooke, Not set
Peking University First Hospital - Oncology Department, Beijing, Beijing
Zhongnan hospital ,Wuhan University, Wuhan, Hubei
Hunan Cancer Hospital - Oncology Department, Changsha, Hunan
The Affiliated Hospital of Inner Mongolia Medical University, Hohehot, Inner Mongolia
Nanjing First Hospital, Nanjing, Jiangsu
Fudan University Shanghai Cancer Center - Oncology Department, Shanghai, Jiangsu
West China Hospital,Sichuan University, Chengdu, Sichuan
The 1st Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang
Peking Union Medical College Hospital (PUMCH) - East Location, Beijing, Not set
Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University, Nanjing, Not set
Ruijin Hosp. Shanghai Jiaotong Univ.School of Medicine, Shanghai, Not set
Tianjin Cancer Hospital, Airport Hospital, Tianjin, Not set
Fakultni nemocnice u Sv. Anny, Onkologicko-chirurgicke oddeleni, Brno, Not set
Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP), Brno, Not set
Multiscan s.r.o., Department: Ambulance klinické onkologie Nemocnice Horovice, Horovice, Not set
Fakultni Nemocnice Olomouc (FNOL) - Onkologicka Klinika, Olomouc, Not set
Thomayerova Nemocnice (TN) (Thomayers Hospital) - Onkologicka Klinika 1. LF UK A TN, Prague, Not set
Fakultni nemocnice v Motole, Onkologicka klinika 2. LF UK a FN Motol, Prague, Not set
Všeobecná fakultní nemocnice v Praze - Urologická klinika, Praha 2, Not set
Aalborg University Hospital, Aalborg, Not set
Aarhus Universitetshospital, Aarhus N, Not set
Rigshospitalet - Kræftbehandling, København Ø, Not set
Sjællands University hospital Næstved, Næstved, Not set
HUS, Meilahden sairaala, Helsinki, Uusimaa
Docrates Klinikka, Helsinki, Not set
Oulun yliopistollinen sairaala, Oulu, Not set
Tampereen yliopistollinen sairaala, Tampere, Not set
Turun yliopistollinen keskussairaala, Turku, Not set
Center Hospitalier Michallon - Grenoble - Service d Urologie et de la transplantation Renale, La Tronche, Grenoble Cedex 9
Centre d' Oncologie du Pays Basque Clinique Belharra - Bayonne - Oncologie medicale, Bayonne, Not set
CHRU Besancon - Hopital Jean Minjoz, Besancon, Not set
CHU Bordeaux - Hopital Pellegrin - Service urologie, Bordeaux, Not set
Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie, Brest, Not set
Centre Hospitalier Universitaire de Clermont Ferrand - Gabriel Montpied - Service Urologie, Clermont- Ferrand, Not set
APHP - Hopital Henri Mondor - Departement Urologie, Creteil, Not set
Institut de cancerologie de Bourgogne - Departement radiotherapie, Dijon, Not set
Centre Georges Francois Leclerc Dijon - service de radiotherapie, Dijon, Not set
Hopital Claude Huriez - Lille - Urologie, Lille, Not set
Hopital Prive Le Bois - Centre Bourgogne - Service radiotherapie oncologie, Lille, Not set
UNICANCER - Centre Leon-Berard (CLB) - Medical oncology, Lyon Cedex 08, Not set
AP-HM - Hopital de la Timone, Marseille, Not set
Clinique Clementville, Montpellier, Not set
Institut Curie - Paris - Oncologie Radiotherapie, Paris, Not set
Hopital Bichat - Paris, Paris, Not set
HCL - Centre Hospitalier Lyon Sud, Pierre Benite, Not set
Institut de Cancerologie Jean Godinot - Departement oncologie medicale, Reims, Not set
CHU Rennes - Hopital Pontchaillou, Rennes Cedex, Not set
Institut de Cancerologie de l'Ouest - Saint Herblain - Unite de therapie precoce, Saint Herblain, Not set
Institut Curie - Saint-Cloud, Saint-Cloud, Not set
ICANS - Institut de Cancerologie de Strasbourg Europe, Strasbourg, Not set
Institut Claudius Regaud - iUCT Oncopole - Service oncologie, Toulouse, Not set
CHU Tours - Hopital Bretonneau, Tours, Not set
Institut de Cancérologie de Lorraine - Alexis Vautrin, Vandoeuvre-les-Nancy, Not set
Gustave Roussy - Departement Oncologie-Radiotherapie, Villejuif, Not set
Klinikum Mannheim GmbH, Mannheim, Baden-Württemberg
Studienpraxis Urologie, Nürtingen, Baden-Württemberg
Klinikum rechts der Isar, München, Bavaria
Klinikum der Universität Würzburg, Wurzburg, Bayern
Universitätsklinikum der Johann Wolfgang Goethe Universität, Frankfurt, Hessen
Städtisches Klinikum Braunschweig gGmbH, Brunswick, Lower Saxony
Universitätsmedizin der Georg-August-Universität Göttingen, Göttingen, Lower Saxony
Urologicum Duisburg, Duisburg, Nordrhein-Westfalen
Universitätsklinikum Köln, Köln, Nordrhein-Westfalen
Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen
Marienhospital Herne Universitätsklinik, Herne, NRW
Medizinische Fakultät der Otto-von-Guericke Universität, Magdeburg, Sachsen-Anhalt
Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Sachsen
Universitätsklinikum Aachen / Klinik und Poliklinik für Urologie und Kinderurologie, Aachen, Not set
Marien-Krankenhaus Bergisch Gladbach, Bergisch Gladbach, Not set
Vivantes Klinikum Am Urban, Berlin, Not set
Charité Campus Benjamin Franklin (CBF), Berlin, Not set
Universitätsklinikum Hamburg-Eppendorf - Martini-Klinik am UKE GmbH, Hamburg, Not set
Universitaetsklinikum Jena - Klinik fuer Urologie, Jena, Not set
Universitätsklinikum Schleswig-Holstein/ Klinik für Urologie, Kiel, Not set
Johannes Gutenberg-Universität Mainz - Urologie, Mainz, Not set
Klinikum Stuttgart / Klinik für Urologie und Transplantationschirurgie, Stuttgart, Not set
Urologische Gemeinschaftspraxis Wesel, Wesel, Not set
Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, Urologiai Klinika, Budapest, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Budapesti Uzsoki Utcai Kórház, Budapest, Not set
Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet, Budapest, Not set
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz, Gyor, Not set
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz, Nyiregyhaza, Not set
Rambam Health Corporation, Haifa, Not set
Hadassah Hebrew University Hospital Ein Kerem, Jerusalem, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department, Petah Tikva, Not set
Sheba Medical Center, Tel Hashomer, Not set
Sourasky Medical Center, Tel-Aviv, Not set
IRCCS Istituto Nazionale Tumori Fondazione Pascale - S. C. Oncologia Clinica Sperimentale Uro-Ginecologica, Napoli, Campania
Azienda Unita Sanitaria Locale Di Bologna_Ospedale Bellaria - Oncologia Medica, Bologna, Emilia-Romagma
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Urologia, Bologna, Emilia-Romagna
Azienda Ospedaliero Universitaria di Modena_Policlinico - Oncologia, Modena, Emilia-Romagna
Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Oncologia Provinciale, Reggio Emilia, Emilia-Romagna
Centro di Riferimento Oncologico di Aviano - Oncologia Radioterapica, Aviano, Friuli-Venezia Giulia
I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena - Urologia, Roma, Lazio
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Degenza di Radioterapia Oncologica, Roma, Lazio
IRCCS Ospedale Policlinico San Martino - Oncologia Medica 1, Genova, Liguria
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Oncologia, Bergamo, Lombardia
Ospedale San Raffaele s.r.l - Urologia, Milano, Lombardia
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardia
Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia, Rozzano, Lombardia
A.O.U. Città della Salute e della Scienza di Torino_Molinette - Urologia U, Torino, Piemonte
Azienda Universitaria Ospedaliera Consorziale Policlinico Bari, Bari, Puglia
Azienda Ospedaliero Universitaria Ospedali Riuniti_Foggia - Oncologia Medica e Terapia Biomolecolare Universitaria, Foggia, Puglia
Azienda Provinciale Per I Servizi Sanitari_Ospedale Santa Chiara - UO Oncologia Medica, Trento, Trentino
A.O. di Perugia_Hospital Santa Maria della Misericordia - S.C. Radioterapia Oncologica, Perugia, Umbria
Istituto Oncologico Veneto_Castelfranco Veneto - UOC Urologia Oncologica, Castelfranco Veneto, Veneto
Azienda Ospedaliera Policlinico Universitario Tor Vergata - UOC Radioterapia, Roma, Veneto
IRCCS Ospedale Sacro Cuore Don Calabria, Verona, Veneto
A.O.U.I. Verona, Verona, Veneto
Cliniche Gavazzeni S.p.A - Dipartimento Area Chirurgia Unità Operativa di Urologia, Bergamo, Not set
Azienda Ospedaliera Santa Croce e Carle - Oncologia, Cuneo, Not set
Hokkaido University Hospital, Sapporo, Hokkaido
Kanazawa University Hospital, Kanazawa, Ishikawa
Yokohama City University Hospital, Yokohama, Kanagawa
The University of Osaka Hospital, Suita, Osaka
Institute of Science Tokyo Hospital, Bunkyo-ku, Tokyo
Kagoshima University Hospital, Kagoshima, Not set
Kyoto University Hospital, Kyoto, Not set
Catharina Ziekenhuis, Eindhoven, Noord-Brabant
Albert Schweitzer Hospital | Internal Medicine - Oncology Department, Dordrecht, Not set
University Medical Center Groningen | Urology Department, Groningen, Not set
Tergooi MC | Hilversum - Wetenschapsbureau, Hilversum, Not set
St. Antonius Ziekenhuis | Utrecht - R&D Interne Geneeskunde, Nieuwegein, Not set
St. Franciscus Gasthuis, Rotterdam, Not set
HagaZiekenhuis van Den Haag, The Hague, Not set
Canterbury Urology Research Trust, Christchurch, Canterbury
Auckland City Hosptial, Auckland, Not set
MidCentral District Health Board (MDHB) - Palmerston North Hospital (PNH), Palmerston North, Not set
Tauranga Urology Research Limited, Tauranga, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set
Swietokrzyskie Centrum Onkologii, Kielce, Not set
Centrum Medyczne iMed24, Krakow, Not set
Medrise Sp. z o.o. Centrum Badan Klinicznych, Lublin, Not set
Szpital Grochowski im. dr.med. Rafala Masztaka, Warszawa, Not set
EMC Instytut Medyczny SA, Wroclaw, Not set
Instituto Portugues de Oncologia de Lisboa | Unidade de Investigacao Clinica - Departamento de Urologia, Lisbon, Lisboa
Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set
Unidade Local Saúde Coimbra, E.P.E, Coimbra, Not set
Companhia Uniao Fabril | Hospital CUF Tejo - Academic Center - Research Center, Lisboa, Not set
Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica, Lisboa, Not set
Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica, Lisboa, Not set
Hospital Santa Maria | Centro de Investigacao Clinica, Lisboa, Not set
Centro Hospitalar Universitario do Porto, Porto, Not set
Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña
Hospital Universitario Marques De Valdecilla - Urologia, Santander, Cantabria
Hospital Universitario Virgen De La Victoria - Urologia, Malaga, Málaga
Hospital del Mar, Barcelona, Not set
Fundacio Puigvert - Urologia, Barcelona, Not set
Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set
Hospital Clínic i Provincial de Barcelona, Barcelona, Not set
Hospital Universitario Puerta del Mar - Urologia, Cadiz, Not set
MD Anderson International Espanya, S.A. - Oncologia Radioterapica, Madrid, Not set
Hospital Universitario Ramon Y Cajal - Oncologia Radioterapica, Madrid, Not set
The START Center for Cancer Care - Madrid - CIOCC - Hospital Universitario Madrid Sanchinarro - Oncologia, Madrid, Not set
Hospital General Universitario Morales Meseguer - Urologia, Murcia, Not set
Hospital Universitario Virgen Del Rocio S.L. - Urologia, Sevilla, Not set
Hospital Universitario Y Politecnico La Fe - Oncologia Radioterapica, Valencia, Not set
Instituto Valenciano de Oncología, Valencia, Not set
Goteborgs Universitet, Gothenburg, Not set
Skane University Hospital - Department of Urology, Malmo, Not set
Uppsala University Hospital, Urology Department, Uppsala, Not set
Tungs' Taichung MetroHarbor Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Koo Foundation Sun Yet-Sen Cancer Centre, Taipei, Not set
Chang Gung Memorial Hospital at Linkou, Taoyuan, Not set
Bedford Hospital - Bedfordshire Hospitals NHS Foundation Tru, Bedford, Bedfordshire
East and North Hertfordshire NHS Trust - Mount Vernon Hospital - Mount Vernon Cancer Centre (MVCC), Northwood, Middlesex
Royal Surrey NHS Foundation Trust | Royal Surrey County Hospital - Cancer Centre, Guildford, Surrey
University College London Hospitals NHS Foundation Trust | University College Hospital (UCLH) - Cancer Clinical Trials Unit, London, Not set
The Royal Marsden NHS Foundation Trust | The Royal Marsden Hospital - The Royal Marsden Clinical Trials Unit (CTU), London, Not set
Imperial College Healthcare NHS Trust | Charing Cross Hospital - Cancer Services, London, Not set
Conditions: Biochemically Recurrent Prostate Cancer
Study of Oral MRT-2359 in Selected Cancer Patients
Recruiting
This Phase 1/2, open-label, multicenter study is conducted in patients with previously treated selected solid tumors, including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), high-grade neuroendocrine cancer of any primary site, diffuse large B-cell lymphoma (DLBCL), and tumors with L-MYC or N-MYC amplification. Patients receive escalating doses of a GSPT1 molecular glue degrader MRT-2359 to determine safety, tolerability, maximum tolerated dose (MTD) and/or recommended Phase... Read More
This Phase 1/2, open-label, multicenter study is conducted in patients with previously treated selected solid tumors, including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), high-grade neuroendocrine cancer of any primary site, diffuse large B-cell lymphoma (DLBCL), and tumors with L-MYC or N-MYC amplification. Patients receive escalating doses of a GSPT1 molecular glue degrader MRT-2359 to determine safety, tolerability, maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of MRT-2359. Once the MTD and/or RP2D is identified, additional patients enroll to Phase 2 study, which includes molecular biomarkers stratification or selection, namely expression or amplification of L-MYC and N-MYC genes, hormone receptor positive (HR)-positive, human epidermal growth factor 2 (HER2)-negative breast cancer and prostate cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Honor Health Research Institute, Scottsdale, Arizona +21 locations
Honor Health Research Institute, Scottsdale, Arizona
Hoag Memorial Hospital Presbyterian, Newport Beach, California
University of California San Diego, San Diego, California
Yale University, New Haven, Connecticut
Sarah Cannon Research Institute, Lake Mary, Florida
Indiana University, Bloomington, Indiana
University of Kansas Cancer Center, Lawrence, Kansas
Dana Farber Cancer Institute, Boston, Massachusetts
Henry Ford Cancer Institute, Detroit, Michigan
South Texas Accelerated Research Therapeutics (START) Midwest, Grand Rapids, Michigan
Washington University, St. Louis, Missouri
Memorial Sloan Kettering Cancer Center, New York, New York
Columbia University Irving Medical Centre, New York, New York
Sarah Cannon Research Institute, Nashville, Tennessee
Mary Crowley Cancer Research, Dallas, Texas
MD Anderson Cancer Center, Houston, Texas
South Texas Accelerated Research Therapeutics (START), San Antonio, Texas
South Texas Accelerated Research Therapeutics (START) Mountain Region, West Valley City, Utah
Virginia Cancer Specialists Research Institute, Fairfax, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
Cross Cancer Institute, Edmonton, Alberta
Princess Margaret Hospital, Toronto, Ontario
Conditions: NSCLC, SCLC, DLBCL, NSCLC With High or Low L-MYC or N-MYC Expression, High Grade Neuroendocrine Cancer, L-MYC and N-MYC Amplified Solid Tumors, HR-positive, HER2-negative Breast Cancer, Prostate Cancer
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease
Recruiting
This study is open to adults with chronic kidney disease (CKD) that is at risk of getting worse. People who have taken a specific type of medication for kidney disease called SGLT2 inhibitor within 1 month before the study or have certain health conditions cannot take part in this study. The purpose of this study is to find out whether a medicine called vicadrostat, used in combination with another medicine called empagliflozin, works in people with chronic kidney disease.
In this study, partic... Read More
This study is open to adults with chronic kidney disease (CKD) that is at risk of getting worse. People who have taken a specific type of medication for kidney disease called SGLT2 inhibitor within 1 month before the study or have certain health conditions cannot take part in this study. The purpose of this study is to find out whether a medicine called vicadrostat, used in combination with another medicine called empagliflozin, works in people with chronic kidney disease.
In this study, participants are randomly assigned to one of two groups. Participants have an equal chance of being assigned to either group. In one group, participants take the 2 study medicines, vicadrostat and empagliflozin, every day for 3 months. In the other group, participants take placebo and empagliflozin for the first 1.5 months, and then they take vicadrostat and empagliflozin together for the next 1.5 months. The study medicines are taken orally as tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine.
Participants are in the study for about 4 months. During this time, they visit the study site multiple times. Doctors regularly test kidney function by measuring specific proteins in the blood and urine.
The results are compared between the two groups to see whether there are differences between starting the study medicines at the same time or one after the other. The doctors also regularly check participants' health and take note of any unwanted effects. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Apogee Clinical Research, Huntsville, Alabama +155 locations
Apogee Clinical Research, Huntsville, Alabama
Orange County Clinical Trials, Anaheim, California
North America Research Institute, San Dimas, California
Valiance Clinical Research-Tarzana-68237, Tarzana, California
Amicis Research Center - Valencia, Valencia, California
Focus Clinical Research, West Hills, California
Western Nephrology, Arvada, Arvada, Colorado
Clinical Research of Brandon LLC, Brandon, Florida
Hillcrest Medical Research, DeLand, Florida
Encore Medical Research, Hollywood, Florida
San Marcus Research Clinic, Inc., Miami Lakes, Florida
Finlay Medical Research Corp, Miami, Florida
Total Research Group, LLC, Miami, Florida
West Orange Endocrinology, Ocoee, Florida
Florida Kidney Physicians - Riverview/Brandon, Riverview, Florida
Masters of Clinical Research, Inc, Augusta, Georgia
Velocity Clinical Research, Savannah, Savannah, Georgia
Boise Kidney and Hypertension, PLLC, Boise, Idaho
Research by Design, LLC, Chicago, Illinois
Nephrology Associates of Northern Illinois and Indiana - Oak Brook, Hinsdale, Illinois
Nephrology Associates of Northern Illinois and Indiana - Fort Wayne, Fort Wayne, Indiana
Kansas Nephrology Research Institute, LLC, Wichita, Kansas
LSU Health Sciences Center, New Orleans, Louisiana
Northwest Louisiana Nephrology, Shreveport, Louisiana
Aa Mrc Llc, Flint, Michigan
Michigan Kidney Consultants, Pontiac, Michigan
Sky Clinical Research, Fayette, Mississippi
Midwest Nephrology Associates, Saint Peters, Missouri
Endocrine Associates of Long Island, Smithtown, New York
Durham Nephrology Associates, Durham, North Carolina
Lucas Research, Inc., Morehead City, North Carolina
Brookview Hills Research Associates LLC, Winston-Salem, North Carolina
Heritage Valley Medical Group, Beaver, Pennsylvania
Southeast Renal Research Institute, Chattanooga, Tennessee
Arlington Nephrology, Arlington, Texas
Endocrine Associates, Houston, Texas
Clinical Advancement Center, PLLC, San Antonio, Texas
Javara Inc.-Stephenville-68996, Stephenville, Texas
Utah Kidney Research Institute, Salt Lake City, Utah
Tidewater Physicians Multispecialty Group, Newport News, Virginia
CEDIC - Centro de Investigacion Clinica, Caba, Not set
Mautalen- Salud e Investigacion, Caba, Not set
Sanatorio Güemes, Capital Federal, Not set
IDIM - Instituto de Diagnostico e Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires, Not set
Instituto Medico Catamarca - IMEC, Rosario, Not set
CEMEDIC - Centro de Especialidades Medicas, Villa Luro, Not set
John Hunter Hospital, New Lambton Heights, New South Wales
Westmead Hospital, Westmead, New South Wales
Austin Health, Heidelberg, Victoria
Royal Perth Hospital, Perth, Western Australia
ULB Hopital Erasme, Bruxelles, Not set
Brussels - UNIV Saint-Luc, Bruxelles, Not set
UZ Leuven, Leuven, Not set
Humani - CHU Charleroi - Chimay, Lodelinsart, Not set
Centro de Pesquisa do Hospital Evangélico de Belo Horizonte, Belo Horizonte, Not set
Chronos Pesquisa Clinica, Brasilia, Not set
Galileo Medical Research Ltda, Juiz de Fora, Not set
CEPIC - Centro Paulista de Investigacao Clinica, Sao Paulo, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
Cpquali Pesquisa Clinica Ltda, São Paulo, Not set
Fundação Oswaldo Ramos (Hospital do Rim), São Paulo, Not set
Centro de Pesquisa Clínica de Nefrologia do ICHC, São Paulo, Not set
Bluewater Clinical Research, Sarnia, Ontario
Heart Health Institute (Scarborough), Scarborough, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
Toronto General Hospital, Toronto, Ontario
Diex Recherche (Trois-Rivieres), Trois-Rivieres, Quebec
Beijing Tsinghua Changgung Hospital, Beijing, Not set
West China Hospital of Sichuan University, Chengdu, Not set
NanFang Hosptial, Guangzhou, Not set
Zhejiang Province People's Hospital, Hangzhou, Not set
The Second Hospital of Anhui Medical University, Hefei, Not set
Center Hospital of Jinan, Jinan, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Not set
The First People's Hospital of Nanning, Nanning, Not set
Ningbo Second Hospital, Ningbo, Not set
General Hospital of Ningxia Medical University, Ningxia, Not set
Second Hospital Affiliated to Shantou Medical University, Shantou, Not set
Shenzhen Second People's Hospital, Shenzhen, Not set
First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Not set
Yibin Second People's Hospital, Yibin, Not set
DIKa centrum s.r.o., Havirov, Not set
MILAN KVAPIL s.r.o., Pribram, Not set
Hospital Slany, Internal Department, Slany, Not set
HOP Bicêtre, Le Kremlin-Bicêtre, Not set
HOP Hôtel-Dieu, Nantes, Not set
HOP Civil, Strasbourg, Not set
Klinikum Bielefeld, Bielefeld, Not set
Internistische Gemeinschaftspraxis in Bünde, Bünde, Not set
Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Universitätsklinikum Frankfurt, Frankfurt, Not set
DaVita Clinical Research Germany GmbH Geilenkirchen, Geilenkirchen, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen, Hannover, Not set
Nephrologische Gemeinschaftspraxis, Hamann/Bacinovic/Jacobsen, Rotenburg, Not set
Robert Bosch Gesellschaft für medizinische Forschung mbH, Stuttgart, Not set
DKD Helios Klinik Wiesbaden, Wiesbaden, Not set
Ospedale SS Annunziata, Chieti, Not set
Università degli Studi di Perugia, Perugia, Not set
Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica (BG), Not set
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Not set
Kasugai Municipal Hospital, Aichi, Kasugai, Not set
National Hospital Organization Chibahigashi National Hospital, Chiba, Chiba, Not set
Tsuchiura Kyodo General Hospital, Ibaraki, Tsuchiura, Not set
Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Yokohama, Not set
Osaka General Medical Center, Osaka, Osaka, Not set
Ageo Central General Hospital, Saitama, Ageo, Not set
Omihachiman Community Medical Center, Shiga, Omihachiman, Not set
Tokyo Medical University Hachioji Medical Center, Tokyo, Hachioji, Not set
Korea University Ansan Hospital, Ansan-si, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Not set
Hanyang University Medical Center, Seoul, Not set
Yonsei University Wonju Severance Christian Hospital, Wonju-si, Gangwon State, Not set
Hospital Canselor Tuanku Muhriz, Cheras, Not set
Hospital Sultan Idris Shah Serdang, Kajang, Not set
Tuanku Fauziah Hospital, Kangar, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
Amsterdam UMC Locatie AMC, Amsterdam, Not set
Albert SchweitzerZiekenhuis, Dordrecht, Not set
Catharina Ziekenhuis, Eindhoven, Not set
Bethesda Diabetes Research Center, Hoogeveen, Hoogeveen, Not set
Momentum Clinical Research - Kapiti Coast, Kapiti, Wellington Region
Dunedin Hospital, Dunedin, Not set
Waikato Hospital, Hamilton, Not set
Senor Santo Nino Hospital, Camiling, Not set
Norzel Medical and Diagnostic Clinic, Cebu City, Not set
Institute for Studies on Diabetes Foundation Inc., Marikina City, Not set
Philippine Heart Center, Quezon City, Not set
Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk, Bydgoszcz, Not set
American Heart Of Poland Sp. Z O.O., Chrzanow, Not set
Pro Familia Altera Sp. z o.o., Katowice, Not set
Pro Salus Sp. z o.o. sp.k., Lodz, Not set
FDI Clinical Research - Mayagüez, Mayaguez, Not set
Centro de Salud Milladoiro, A Coruña, Not set
C.A.P. Sardenya, Barcelona, Not set
Centro de Salud Cartagena Casco Antiguo, Cartagena, Not set
Eap Osona Sud Alt Congost S.L.P. Cap Centelles, Centelles, Barcelona, Not set
Centro de Salud Naranco, Oviedo, Not set
Centro de Salud de San Juan, Salamanca, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Mackay Memorial Hospital, Taipei, Not set
King Chulalongkorn Memorial Hospital, Bangkok, Not set
Phramongkutklao Hospital, Bangkok, Not set
Siriraj Hospital, Bangkok, Not set
Maharaj Nakom Chiangmai Hospital, Chiang Mai, Not set
University Hospital Monklands, Airdrie, Not set
Banbury Cross Health Centre, Banbury, Not set
Queen Elizabeth University Hospital, Glasgow, Not set
Belmont Health Centre, Harrow, Not set
Velocity Clinical Research, High Wycombe, High Wycombe, Not set
Richford Gate Medical Practice, London, Not set
Royal Berkshire Hospital, Reading, Not set
Sunderland Royal Hospital, Sunderland, Not set
Conditions: Chronic Kidney Disease
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
Recruiting
The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd).
The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: UCSF Fresno, Clovis, California +228 locations
UCSF Fresno, Clovis, California
City of Hope Cancer Center, Duarte, California
City of Hope Orange County Lennar Foundation Cancer Center, Irvine, California
University of Connecticut, Farmington, Connecticut
Yale New Haven Hospital, New Haven, Connecticut
ChristianaCare Helen F Graham Cancer Center and Research Institute, Newark, Delaware
Cleveland Clinic Florida, Weston, Florida
University Of Illinois Medical Center, Chicago, Illinois
University of Iowa Health Care, Waukee, Iowa
Norton Cancer Institute, Louisville, Kentucky
LSUHSC Shreveport Feist-Weiller Cancer Center, Shreveport, Louisiana
Johns Hopkins University School of Medicine JHUSOM, Baltimore, Maryland
Cancer And Hematology Centers of Western Michigan PC, Grand Rapids, Michigan
Nebraska Cancer Specialists, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Astera Cancer Care, East Brunswick, New Jersey
Christus St. Vincent Regional Cancer Center, Santa Fe, New Mexico
Hematology-Oncology Associates of CNY, East Syracuse, New York
Northwell Health Cancer Institute, Lake Success, New York
NYU Langone Hospital Long Island, Mineola, New York
Perlmutter Cancer Center at NYU Langone Health, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Durham VAMC, Durham, North Carolina
University of Cincinnati, Cincinnati, Ohio
University Hospitals Cleveland Medical Center, Cleveland, Ohio
OhioHealth, Columbus, Ohio
Allegheny Health Network, Pittsburgh, Pennsylvania
Joe Arrington Cancer Research Treatment Center, Lubbock, Texas
Utah Cancer Specialists, Salt Lake City, Utah
NorthWest Medical Specialties, PLLC, Tacoma, Washington
Royal Prince Alfred Hospital, Camperdown, Not set
Barwon Health - University Hospital Geelong, Geelong, Not set
Liverpool Hospital, Liverpool, Not set
Sir Charles Gairdner Hospital, Nedlands, Not set
Calvary Mater Newcastle Hospital, New South Wales, Not set
Wollongong Hospital, Wollongong, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
SCRI CCCIT gem GmbH, Salzburg, Not set
Medical University Vienna, Vienna, Not set
Hanusch Krankenhaus, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
ZAS Cadix, Antwerpen, Not set
Ghent University Hospital, Gent, Not set
Jolimont, Haine Saint Paul La Louviere, Not set
Az Groeninge, Kortrijk, Not set
Universitair Ziekenhuis Leuven, Leuven, Not set
GZA Ziekenhuizen- Campus St Augustinus, Wilrijk, Not set
Fundacao Pio XII, Barretos, Not set
Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte, Not set
Liga Paranaense de Combate ao Cancer, Curitiba, Not set
Instituto Do Cancer Do Ceara, Fortaleza, Not set
Liga Norte Riograndense Contra O Cancer, Natal, Not set
Complexo Hospitalar de Niteroi, Niteroi, Not set
Hospital De Clinicas De Porto Alegre, Porto Alegre, Not set
Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP, Ribeirao Preto, Not set
Hospital Sao Rafael, Salvador, Not set
Hospital Nove de Julho, Sao Paulo, Not set
Clinica Medica Sao Germano S/S LTDA, Sao Paulo, Not set
Hospital Das Clinicas Da Faculdade De Medicina Da USP, Sao Paulo, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
British Columbia Cancer Agency, Vancouver, British Columbia
CHU de Quebec L Hotel Dieu de Quebec, Quebec, Not set
Peking Union Medical College Hospital, Beijing, Not set
Peking University First Hospital, Beijing, Not set
Beijing Tongren Hospital CMU, Beijing, Not set
Changzhou No 2 Peoples Hospital, Chang Zhou, Not set
The First Hospital of Jilin University, Changchun, Not set
The Second Xiangya Hospital of Central South Hospital, Changsha, Not set
Beijing Chaoyang Hospital, Chaoyang District, Not set
Sichuan Provincial Peoples Hospital, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Fujian Meidical University Union Hospital, Fu Zhou, Not set
Nanfang Hospital, Guangzhou, Not set
Sun Yat -Sen University Cancer Center, Guangzhou, Not set
The Second Affiliated Hospital of Zhejiang University, Hang Zhou, Not set
No.1 Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Not set
Harbin medical university cancer hospital, Harbin, Not set
Qilu Hospital of Shandong University, Jinan, Not set
Zhongda Hospital Southeast University, Nan Jing, Not set
The First Affiliated Hospital of Guangxi Medical University, Nan Ning Shi, Not set
The First Affliated Hospital Of Nanchang University, Nanchang, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Ruijin Hospital Shanghai Jiao Tong University, Shanghai, Not set
Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Not set
Shanghai Fourth People s Hospital, Shanghai, Not set
Peking University Shenzhen Hospital, Shen Zhen Shi, Not set
Shengjing Hospital Of China Medical University, Shenyang, Not set
Institute of Hematology and Blood Diseases Hospital, Tian Jin, Not set
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Not set
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set
Wuhan Tongji Hospital Tongji Medical College, WuHan, Not set
The Second Affiliated Hospital of Xi'an Jiaotong University, Xi' An, Not set
The first affiliated hospital of xiamen university, Xiamen, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Fakultni nemocnice Brno, Brno - Bohunice, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni nemocnice Olomouc, Olomouc, Not set
Fakultni Nemocnice Ostrava, Ostrava, Not set
Fakultni nemocnice Plzen, Plzen, Not set
VFN v Praze, Praha, Not set
Aalborg University Hospital, Aalborg, Not set
Regionshospitalet Godstrup, Herning, Not set
Zealand University Hospital, Roskilde, Not set
Vejle Sygehus, Vejle, Not set
APHP - Hopital Henri Mondor, Creteil, Not set
Hopital Claude Huriez, Lille, Not set
CHU Nantes, Nantes, Not set
CHU Hopital Saint Antoine, PARIS cedex 12, Not set
CHU de Bordeaux - Hospital Haut-Leveque, Pessac cedex, Not set
CHU Lyon Sud, Pierre-Benite, Not set
CHU Poitiers - Hopital la Miletrie, Poitiers, Not set
CHU de Rennes - Hopital Pontchaillou, Rennes, Not set
Institut de Cancerologie Strasbourg Europe ICANS, Strasbourg, Not set
Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, Not set
Helios Kliniken Berlin Buch Gmbh, Berlin, Not set
Med. Universitatsklinik Essen, Essen, Not set
Universitaetsklinikum Halle Saale, Halle (Saale), Not set
Universitaetsklinik Hamburg-Eppendorf, Hamburg, Not set
Klinikum Nuernberg Nord, Nuernberg, Not set
Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,, Tübingen, Not set
Universitaetsklinikum Wuerzburg, Wurzburg, Not set
Alexandra General Hospital of Athens, Athens Attica, Not set
G Papanikolaou Hospital of Thessaloniki, Thessalonikis, Not set
Anticancer Hospital of Thessaloniki Theageneio, Thessaloniki, Not set
Rambam Medical Center, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Rabin, Petah Tikva, Not set
Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv Yafo, Not set
ASST Papa Giovanni XXIII Bergamo, Bergamo, Not set
A O U Sant Orsola Malpighi, Bologna, Not set
Careggi University Hospital, Firenze, Not set
Ospedale San Raffaele, Milan, Not set
Azienda Ospedaliera di Rilievo Nazionale A Cardarelli, Naples, Not set
IRCCS Policlinico San Matteo, Università degli studi di Pavi, Pavia, Not set
Universita Degli Studi di Roma Tor Vergata, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino, Torino, Not set
Juntendo University Hospital, Bunkyo Ku, Not set
Chiba Cancer Center, Chiba, Not set
Kameda Medical Center, Chiba, Not set
National Hospital Organization Mito Medical Center, Higashiibaraki-gun, Not set
Kansai Medical University Hospital, Hirakata, Not set
Hyogo Medical University Hospital, Hyôgo, Not set
Saitama Medical University Hospital, Iruma-gun, Not set
Tokai University Hospital, Kanagawa, Not set
Kanazawa University Hospital, Kanazawa, Not set
Kumamoto University Hospital, Kumamoto-shi, Not set
Matsuyama Red Cross Hospital, Matsuyama-City, Not set
National Hospital Organization Nagasaki Medical Center, Nagasaki, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
National Hospital Organization Hokkaido Cancer Center, Sapporo, Not set
National Hospital Organization Shibukawa Medical Center, Shibukawa, Not set
Japanese Red Cross Medical Center, Shibuya-ku, Not set
Shizuoka Cancer Center, Sunto Gun, Not set
Fujita Health University Hospital, Toyoake, Not set
Yamagata University Hospital, Yamagata, Not set
Yamanashi Prefectural Central Hospital, Yamanashi, Not set
Dong-A University Hospital, Busan, Not set
Pusan National University Hospital, Busan, Not set
Kyungpook National University Hospital, Daegu, Not set
National Cancer Center, Goyang si, Not set
Chonnam National University Hwasun Hospital, Hwasun, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Mary s Hospital, Seoul, Not set
VUMC Amsterdam, Amsterdam, Not set
Gelre Ziekenhuis, Apeldoorn, Not set
Reinier de Graaf Gasthuis, Delft, Not set
St. Antonius Ziekenhuis Nieuwegein, Nieuwegein, Not set
Zuyderland Medical Center, Sittard-Geleen, Not set
Oslo University Hospital HF Ulleval sykehus, Oslo, Not set
St. Olavs Hospital, Trondheim, Not set
Wojewodzki Szpital Kliniczny w Bialej Podlaskiej, Biala Podlaska, Not set
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozow, Not set
Szpital Uniwersytecki nr 2 im. Jana Biziela w Bydgoszczy, Bydgoszcz, Not set
Pratia Onkologia Katowice, Katowice, Not set
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce, Not set
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi, Lodz, Not set
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli, Lublin, Not set
Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan, Not set
Szpital Uniwersytecki im Karola Marcinkowskiego w Zielonej Gorze, Zielona Gora, Not set
Uls Braga - Hosp. Braga, Braga, Not set
Champalimaud Foundation Champalimaud Centre, Lisbon, Not set
Instituto Portugues de Oncologia, Porto, Not set
Uls Hosp Sao Joao, Porto, Not set
Hosp. Univ. Germans Trias I Pujol, Badalona, Not set
Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp. Univ. Virgen de Las Nieves, Granada, Not set
Hosp. de Jerez de La Frontera, Jerez de la Frontera, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Hosp. Univ. La Paz, Madrid, Not set
Hosp Univ Hm Sanchinarro, Madrid, Not set
Hosp. Univ. Son Espases, Palma de Mallorca, Not set
Hosp. Quiron Madrid Pozuelo, Pozuelo de Alarcon, Not set
Hosp Clinico Univ de Salamanca, Salamanca, Not set
Hosp. Mutua Terrassa, Terrassa, Not set
Hosp. Clinico Univ. de Valencia, Valencia, Not set
Falu Lasarett, Falun, Not set
Skanes universitetssjukhus, Lund, Not set
Karolinska University Hospital Huddinge, Stockholm, Not set
Universitetssjukhuset Orebro, Örebro, Not set
Inselspital Universitatsspital Bern, Bern, Not set
Kantonsspital St Gallen, St. Gallen, Not set
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Not set
Ankara University Medical Faculty, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Memorial Antalya Hospital, Antalya, Not set
Pamukkale University Medical Faculty, Denizli, Not set
Medipol University Hospital, Istanbul, Not set
Dokuz Eylul University Medical Faculty, Izmir, Not set
Ondokuz Mayis University, Samsun, Not set
University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set
Blackpool Victoria Hospital, Blackpool, Not set
University Hospitals Bristol and Weston, Bristol, Not set
Addenbrooke's Hospital, Cambridge, Not set
Kent and Canterbury Hospital, Canterbury, Not set
Western General Hospital, Edinburgh, Not set
University College London Hospitals, London, Not set
Imperial College Healthcare, London, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Multiple Myeloma
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
Recruiting
This study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medicine called nerandomilast or BI 1015550.
The goal of this study is to find out how well people with pulmonary fibrosis tolerate long- term treatment with nerandomilast. The study also tests whether nerandomilast improves lung function and prolongs the time until symptoms get worse, participants need... Read More
This study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medicine called nerandomilast or BI 1015550.
The goal of this study is to find out how well people with pulmonary fibrosis tolerate long- term treatment with nerandomilast. The study also tests whether nerandomilast improves lung function and prolongs the time until symptoms get worse, participants need to go to the hospital, or die.
Every participant takes nerandomilast as tablets for up to 1 year and 10 months. The participants may also continue their regular treatment for pulmonary fibrosis during the study.
Participants visit their doctors regularly. During these visits, the doctors collect information on any health problems of the participants. Participants also regularly do lung function tests. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +370 locations
University of Alabama at Birmingham, Birmingham, Alabama
University of Arizona, Tucson, Arizona
University of Southern California, Los Angeles, California
Cedars-Sinai Medical Center, Los Angeles, California
University of California Los Angeles, Los Angeles, California
University of California Davis, Sacramento, California
National Jewish Health, Denver, Colorado
Yale University School of Medicine, New Haven, Connecticut
Christiana Hospital, Newark, Delaware
Georgetown University, Washington, District of Columbia
St. Francis Medical Institute, Clearwater, Florida
University of Florida, Gainesville, Florida
Clinical Research Specialists LLC, Kissimmee, Florida
Advanced Pulmonary Research Institute, Loxahatchee Groves, Florida
Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead, Atlanta, Georgia
The Emory Clinic, Atlanta, Georgia
Northshore University Health System, Evanston, Illinois
University of Kansas Medical Center, Kansas City, Kansas
Tulane Medical Center, New Orleans, Louisiana
Johns Hopkins Hospital, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
St. Elizabeth's Medical Center, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
University of Michigan Health System, Ann Arbor, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
University of Minnesota, Minneapolis, Minnesota
Mayo Clinic, Rochester, Rochester, Minnesota
The Lung Research Center, LLC, Chesterfield, Missouri
Creighton University, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Renown Regional Medical Center, Reno, Nevada
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Northern Westchester Hospital, Mount Kisco, New York
Columbia University Medical Center-New York Presbyterian Hospital, New York, New York
NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York
Duke University Medical Center, Durham, North Carolina
Southeastern Research Center-Winston Salem-69289, Winston-Salem, North Carolina
University of Cincinnati, Cincinnati, Ohio
Cleveland Clinic, Cleveland, Ohio
The Ohio State University Wexner Medical Center, Columbus, Ohio
The Oregon Clinic, Portland, Oregon
University of Pennsylvania, Philadelphia, Pennsylvania
Temple University Hospital, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
Infinity Medical Research, Inc., East Providence, Rhode Island
Lowcountry Lung and Critical Care, Charleston, South Carolina
Clinical Trials Center of Middle Tennessee, LLC, Franklin, Tennessee
Vanderbilt University Medical Center, Nashville, Tennessee
Baylor University Medical Center, Dallas, Texas
UT Health San Antonio, San Antonio, Texas
Intermountain Medical Center-Murray-69497, Murray, Utah
University of Utah Health Sciences Center, Salt Lake City, Utah
University of Vermont, Burlington, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Virginia Mason Medical Center, Seattle, Washington
University of Wisconsin, Madison, Wisconsin
Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553, C.a.b.a, Not set
CEDIC - Centro de Investigacion Clinica, Caba, Not set
Hospital Italiano de Buenos Aires, Caba, Not set
Consultorios Médicos del Buen Ayre, Capital Federal, Not set
CEMER-Centro Medico De Enfermedades Respiratorias, Florida, Not set
Instituto Ave Pulmo, Mar del Plata, Not set
INSARES, Mendoza, Not set
Centro Respiratorio de Quilmes, Quilmes, Not set
Instituto Médico de la Fundación Estudios Clínicos, Rosario, Not set
Canberra Hospital, Garran, Australian Capital Territory
Royal Prince Alfred Hospital, Camperdown, New South Wales
Westmead Hospital, Westmead, New South Wales
Lung Research Queensland, Chermside, Queensland
The Prince Charles Hospital, Chermside, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Austin Hospital, Heidelberg, Victoria
The Alfred Hospital, Melbourne, Victoria
Fiona Stanley Hospital, Murdoch, Western Australia
Trialswest, Spearwood, Western Australia
Macquarie University, Macquarie Park, Not set
Krems University Hospital, Krems, Not set
LKH Salzburg University Hospital, Salzburg, Not set
AKH - Medical University of Vienna, Vienna, Not set
Clinic Floridsdorf, Vienna, Not set
Klinikum Wels - Grieskirchen GmbH, Wels, Not set
Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim, Antwerpen, Not set
ULB Hopital Erasme, Bruxelles, Not set
Brussels - UNIV Saint-Luc, Bruxelles, Not set
UNIV UZ Gent, Gent, Not set
UZ Leuven, Leuven, Not set
Centre Hospitalier Universitaire de Liège, Liège, Not set
Yvoir - UNIV UCL de Mont-Godinne, Yvoir, Not set
Serviços Medicos Respirar Sul Fluminense, Barra Mansa, Not set
Hospital das Clinicas da Universidade Federal HC-UFMG, Belo Horizonte,Minas Gerais, Not set
Edumed - Educacao e Saude SA, Curitiba, Not set
CLARE - Clinica de Pneumologia, Goiania, Not set
Hospital Nossa Senhora da Conceição, Porto Alegre - RS, Not set
Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
CEMEC - Centro Multidisciplinar de Estudos Clínicos, São Bernardo do Campo, Not set
Hospital das Clinicas da FMUSP, São Paulo, Not set
University of Alberta Hospital (University of Alberta), Edmonton, Alberta
Kelowna Respirology & Allergy Research, Kelowna, British Columbia
St. Paul's Hospital (Vancouver), Vancouver, British Columbia
Vancouver General Hospital, Vancouver, British Columbia
Dr. Georges-L.-Dumont University Hospital Centre, Moncton, New Brunswick
QEII Health Sciences Centre, Halifax, Nova Scotia
St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Dr. Syed Anees Medicine Professional Corporation, Windsor, Ontario
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec
McGill University Health Centre (MUHC), Montreal, Quebec
CIC Mauricie Inc., Trois-Rivieres, Quebec
Royal University Hospital (Saskatoon), Saskatoon, Saskatchewan
IUCPQ (Laval University), Quebec, Not set
Instituto Nacional del Tórax, Providencia, Santiago De Chile, Not set
Centro de Investigación del Maule, Talca, Not set
Beijing Chao-Yang Hospital, Beijing, Not set
China-Japan Friendship Hospital, Beijing, Not set
Peking Union Medical College Hospital, Beijing, Not set
The Second Xiangya Hospital Of Central South University, Changsha, Not set
West China Hospital of Sichuan University, Chengdu, Not set
People's Hospital of Sichuan Province, Chengdu, Not set
First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
NanFang Hosptial, Guangzhou, Not set
Hangzhou First People's Hospital, Hangzhou, Not set
The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Not set
Zhejiang Hospital, Hangzhou, Not set
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Not set
Anhui Provincial Hospital, Hefei, Not set
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Not set
The First hospital of Jiaxing, Jiaxing, Not set
Jinhua Municipal Central Hospital, Jinhua, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Ningbo Medical Center Lihuili Hospital, Ningbo, Not set
The First Affiliated Hospital of Ningbo University, Ningbo, Not set
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Not set
Shanghai Chest Hospital, Shanghai, Not set
Zhongshan Hospital Affiliated to Fudan University, Shanghai, Not set
Huadong Hospital affiliated to Fudan University, Shanghai, Not set
China Shenyang Chest Hospital, Shenyang, Not set
Shenzhen People's Hospital, Shenzhen, Not set
The University of Hong Kong-Shenzhen Hospital, Shenzhen, Not set
The First Affiliated Hospital of Soochow University, Suzhou, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
The First Affiliated Hospital of Wenzhou Med College, Wenzhou, Not set
Wuhan Union Hospital, Wuhan, Not set
Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T, Wuhan, Not set
Renmin Hospital of Wuhan University, Wuhan, Not set
Wuxi People's Hospital, Wuxi, Not set
Second Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Not set
Affiliated Hospital, Xuzhou Medical college, Xuzhou, Not set
Yichang NO.1 People's Hospital, Yichang, Not set
General Hospital of Ningxia Medical University, Yinchuan, Not set
University hospital center Zagreb, Zagreb, Not set
University Hospital Dubrava, Zagreb, Not set
Solmed Polyclinic, Zagreb, Not set
Thomayer University Hospital, Praha 4, Not set
Gentofte Hospital, Hellerup, Not set
Odense University Hospital, Odense C, Not set
North Estonia Medical Centre Foundation, Tallinn, Tallinn, Not set
HYKS Keuhkosairauksien tutkimusyksikkö, Helsinki, Not set
Oulun yliopistollinen keskussairaala, Oulu, Not set
Tampere University Hospital, Tampere, Not set
TYKS, Turku, Not set
HOP d'Angers, Angers, Not set
HOP Avicenne, Bobigny, Not set
HOP de la Cavale Blanche, Brest, Not set
HOP Louis Pradel, Bron, Not set
HOP CHU Caen, Caen, Not set
HOP François Mitterrand, Dijon, Not set
HOP Michallon, La Tronche, Not set
HOP Bicêtre, Le Kremlin-Bicêtre, Not set
INS Coeur Poumon, Lille, Not set
HOP Nord, Marseille, Not set
HOP Nord Laennec, Nantes, Not set
HOP Pasteur, Nice, Not set
HOP Paris Saint-Joseph, Paris, Not set
HOP Européen G. Pompidou, Paris, Not set
HOP Bichat, Paris, Not set
HOP Haut-Lévêque, Pessac, Not set
HOP Robert Debré, Reims, Not set
HOP Pontchaillou, Rennes, Not set
HOP Charles Nicolle, Rouen, Not set
HOP Foch, Suresnes, Not set
HOP Larrey, Toulouse, Not set
National Center for Tuberculosis and Lung Diseases, Tbilisi, Tbilisi, Not set
LLC Diacor, Tbilisi, Not set
LTD The First Medical Center, Tbilisi, Not set
Velocity Clinical Research Germany GmbH, Ahrensburg, Ahrensburg, Not set
CIMS Studienzentrum Bamberg GmbH, Bamberg, Not set
Vivantes Netzwerk für Gesundheit GmbH, Berlin, Not set
Universitätsklinikum Bonn AöR, Bonn, Not set
Fachkrankenhaus Coswig GmbH, Coswig, Not set
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH, Essen, Not set
Universitätsklinikum Hamburg, Eppendorf, Hamburg, Not set
Klinikum Region Hannover GmbH, Hannover, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg, Heidelberg, Not set
Lungenklinik Hemer, Hemer, Not set
Lungenfachklinik Immenhausen, Immenhausen, Not set
Klinikum Konstanz, Konstanz, Not set
Klinikum der Universität München AÖR, München, Not set
Klinikum Nürnberg, Nürnberg, Not set
Krankenhaus Bethanien gGmbH, Solingen, Not set
Helios Hanseklinikum Stralsund, Stralsund, Not set
Robert Bosch Gesellschaft für medizinische Forschung mbH, Stuttgart, Not set
Universitätsklinikum Tübingen, Tübingen, Not set
Hospital of Heraklion (PAGNI), Heraclion, Not set
Univ. Gen. Hosp. of Ioannina, Ioannina, Not set
Univ. Gen. Hosp. of Patras, Patras, Not set
General Hospital of Thessaloniki "Hippokrateio", Thessaloniki, Not set
Semmelweis University, Budapest, Not set
Koranyi National Institute For Pulmonolgy, Budapest, Not set
University of Debrecen Clinical Centre, Debrecen, Not set
Bhatia Hospital, Mumbai, Not set
P.D. Hinduja National Hospital, Mumbai, Not set
Connolly Hospital Blanchardstown, Dublin 15, Not set
Shamir Medical Center (Assaf Harofeh), Beer Yaakov, Not set
Lady Davis Carmel Medical Center, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem 91031, Jerusalem, Not set
Sourasky Medical Center, Tel Aviv, Not set
ASST degli Spedali Civili di Brescia, Brescia, Not set
A.O.U. Policlinico Vittorio Emanuele, Catania, Not set
A. O. Universitaria Careggi, Firenze, Not set
Ospedale Colonnello D Avanzo, Foggia, Not set
Ospedale G.B. Morgagni, Forli', Not set
Ospedale San Paolo-MILANO-18793, Milano, Not set
Ospedale Classificato San Giuseppe, Milano, Not set
Azienda Ospedaliera Policlinico di Modena, Modena, Not set
A.O. San Gerardo di Monza, Monza, Not set
Azienda Ospedaliera Universitaria di Padova, Padova, Not set
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Not set
A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena, Not set
Ospedali Riuniti di Ancona, Torrette Di Ancona (Ancona), Not set
Tosei General Hospital, Aichi, Seto, Not set
Chiba University Hospital, Chiba, Chiba, Not set
University of Fukui Hospital, Fukui, Yoshida-gun, Not set
National Hospital Organization Kyushu Medical Center, Fukuoka, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Fukuoka, Not set
Aso Co.,Ltd Iizuka Hospital, Fukuoka, Iizuka, Not set
Hospital of the University of Occupational and Environmental Health, Fukuoka, Kitakyushu, Not set
Kurume University Hospital, Fukuoka, Kurume, Not set
Fukushima Medical University Hospital, Fukushima, Fukushima, Not set
Tsuboi Hospital, Fukushima, Koriyama, Not set
Hiroshima Prefectural Hospital, Hiroshima, Hiroshima, Not set
Sapporo Medical University Hospital, Hokkaido, Sapporo, Not set
Hokkaido University Hospital, Hokkaido, Sapporo, Not set
National Hospital Organization Himeji Medical Center, Hyogo, Himeji, Not set
Kobe City Medical Center General Hospital, Hyogo, Kobe, Not set
Kobe City Hospital Organization Kobe City Medical Center West Hospital, Hyogo, Kobe, Not set
Kagawa University Hospital, Kagawa, Kita-gun, Not set
Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Yokohama, Not set
Saiseikai Kumamoto Hospital, Kumamoto, Kumamoto, Not set
Tohoku University Hospital, Miyagi, Sendai, Not set
Nagasaki University Hospital, Nagasaki, Nagasaki, Not set
Kindai University Hospital, Osaka, Osakasayama, Not set
National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Sakai, Not set
Osaka Medical and Pharmaceutical University Hospital, Osaka, Takatsuki, Not set
Saitama Red Cross Hospital, Saitama, Saitama, Not set
Shimane University Hospital, Shimane, Izumo, Not set
Hamamatsu University Hospital, Shizuoka, Hamamatsu, Not set
Jichi Medical University Hospital, Tochigi, Shimotsuke, Not set
Tokushima University Hospital, Tokushima, Tokushima, Not set
Juntendo University Hospital, Tokyo, Bunkyo-ku, Not set
Nippon Medical School Hospital, Tokyo, Bunkyo-ku, Not set
Toranomon Hospital, Tokyo, Minato-ku, Not set
Kyorin University Hospital, Tokyo, Mitaka, Not set
Toho University Omori Medical Center, Tokyo, Ota-ku, Not set
Tokyo Medical University Hospital, Tokyo, Shinjuku-ku, Not set
Keio University Hospital, Tokyo, Shinjuku-ku, Not set
National Center for Global Health and Medicine, Tokyo, Shinjuku-ku, Not set
Wakayama Medical University Hospital, Wakayama, Wakayama, Not set
The Catholic University of Korea, Bucheon St.Mary's Hospital, Bucheon, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
Kyung Hee University Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
Soonchunhyang University Hospital Seoul, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Hospital Pulau Pinang-Pulau Pinang-21953, George Town, Not set
Hospital Sultan Idris Shah Serdang, Kajang, Not set
Institut Perubatan Respiratori, Kuala Lumpur, Not set
Sarawak General Hospital, Kuching, Not set
Centro de Investigacion Integral MEDIVEST S.C, Chihuahua, Not set
Soltmed Smo, Ciudad de Mexico, Not set
Centro Respiratorio de Mexico, Ciudad de Mexico, Not set
CREPID Aire y Salud, Coyoacan, Not set
Centro de Investigacion Farmacologica del Bajío, S.C., Guanajuato, Not set
Centro de Prevención y Rehabilitación de Enfermedades Pulmon, Monterrey, Not set
Oaxaca Site Management Organization, S.C., Oaxaca, Not set
Zuyderland Medisch Centrum, HEERLENHeerlen, Not set
Leids Universitair Medisch Centrum (LUMC), Leiden, Not set
St. Antonius ziekenhuis, locatie Nieuwegein, Nieuwegein, Not set
Erasmus Medisch Centrum-ROTTERDAM-50697, Rotterdam, Not set
Waikato Hospital, Hamilton, Not set
Greenlane Clinical Centre, One Tree Hill, Auckland, Not set
Tauranga Hospital, Tauranga South, Not set
Haukeland Universitetssykehus, Bergen, Not set
Akershus Universitetssykehus HF, Nordbyhagen, Not set
Oslo Universitetssykehus HF, Rikshospitalet, Oslo, Not set
University Clinical Center, Gdansk, Gdansk, Not set
Leszek Giec Upper-Silesian Med.Cent.Silesian Med.Univ., Katowice, Not set
Alergopneuma Medical Center, Swidnik, Not set
Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa, Warsaw, Not set
University Clinical Center of the Medical University of Warsaw, Warsaw, Not set
ULS Braga, Braga, Not set
ULS de Coimbra, E.P.E., Coimbra, Not set
ULS de São José, E.P.E., Lisboa, Not set
USLM, EPE - Hospital Pedro Hispano, Matosinhos, Not set
ULS de Gaia/Espinho, EPE, Vila Nova de Gaia, Not set
King Abdullah International Medical Research Center, Riyadh, Not set
University Clinical Center of Serbia, Belgrade, Not set
University Clinical Center Nis, Nis, Not set
Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Not set
Singapore General Hospital, Singapore, Not set
Tan Tock Seng Hospital, Singapore, Not set
Hospital Golnik - Univ. Clinic of Pulmonary and Allergic Diseases, Golnik, Not set
Enhancing Care Foundation NPC, Mount Edgecombe, Not set
Hospital General Universitario de Alicante, Alicante, Not set
Hospital del Mar, Barcelona, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital de Basurto, Bilbao, Not set
Hospital Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital de Galdakao, Galdakao, Not set
Hospital Universitario Virgen de las Nieves, Granada, Not set
Hospital de Bellvitge, L'Hospitalet de Llobregat, Not set
Hospital La Princesa, Madrid, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Universitario Infanta Leonor, Madrid, Not set
Hospital Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Virgen de la Victoria, Malaga, Not set
Hospital Central de Asturias, Oviedo, Not set
Hospital Son Espases, Palma de Mallorca, Not set
Hospital Quirónsalud Madrid, Pozuelo de Alarcón, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Clínico de Santiago, Santiago de Compostela, Not set
Hospital Virgen del Rocío, Sevilla, Not set
Hospital Nuestra Señora de Valme, Sevilla, Not set
Hospital General Universitario de Valencia, Valencia, Not set
Universitetssjukhuset, Linköping, Linköping, Not set
Akademiska sjukhuset, Uppsala, Not set
Universitätsspital Basel, Basel, Not set
Chang-Hua Christian Hospital, Changhua, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Taichung Veterans General Hospital, Taichung, Not set
NCKUH, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Siriraj Hospital, Bangkok Noi, Not set
Srinagarind Hospital, Khon Kaen, Not set
Maharat Nakhonchiangmai Hospital, Muang, Not set
Ramathibodi Hospital, Ratchatewi, Not set
Songklanagarind Hospital, Songkhla, Not set
Gulhane Training and Research Hospital, Ankara, Not set
Ankara Universitesi Tip Fakultesi, Ankara, Not set
Akdeniz Universitesi Tip Fakultesi -ANTALYA-33606, Antalya, Not set
Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, Not set
Gazi Universitesi Tip Fakultesi, Yenimahalle/ANKARA, Not set
Aberdeen Royal Infirmary, Aberdeen, Not set
Queen Elizabeth Hospital Birmingham, Birmingham, Not set
Southmead Hospital, Bristol, Not set
Royal Infirmary of Edinburgh, Edinburgh, Not set
Royal Devon and Exeter Hospital, Wonford, Exeter, Not set
Royal Lancaster Infirmary, Lancaster, Not set
St James's University Hospital, Leeds, Not set
Altnagelvin Area Hospital, Londonderry, Not set
Guy's Hospital, London, Not set
Royal Brompton Hospital, London, Not set
Wythenshawe Hospital, Manchester, Not set
Churchill Hospital, Oxford, Not set
Southampton General Hospital, Southampton, Not set
Conditions: Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
Brief Intervention and Contact Program Main Trial
Recruiting
Suicide is a significant public health concern and causes approximately 1.5% of all deaths in the general population in Canada. Research shows that for individuals with comorbid psychiatric illness and suicidal behaviour, the risk of further suicide attempts persists in the first two years post-discharge with the most vulnerable time being the period immediately post discharge.
Several studies have found that alongside usual treatment, follow-up with discharged patients through text messaging,... Read More
Suicide is a significant public health concern and causes approximately 1.5% of all deaths in the general population in Canada. Research shows that for individuals with comorbid psychiatric illness and suicidal behaviour, the risk of further suicide attempts persists in the first two years post-discharge with the most vulnerable time being the period immediately post discharge.
Several studies have found that alongside usual treatment, follow-up with discharged patients through text messaging, phone calls and letters, contributes to a reduction in attempts and death by suicide, and instances of self-harm. In particular, brief contact interventions have shown positive impacts in reducing further completed suicide and suicidal behaviour in patients presenting to the emergency department following a suicide attempt.
The BIC model followed in this study is adapted from the WHO protocol that was utilised as part of the Multisite Intervention Study On Suicidal Behaviours (SUPRE-MISS). Read Less
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/19/2025
Locations: St. Joseph's Healthcare, Hamilton, Not set
St. Joseph's Healthcare, Hamilton, Not set
Conditions: Suicidal Behavior
A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab
Recruiting
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study aims to provide data on the efficacy and safety of upadacitinib at different doses in adult participants with moderate to severe AD.
Upadacitinib is an approved drug for the treatment of moderate to severe atopic dermatitis (AD). This stud... Read More
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study aims to provide data on the efficacy and safety of upadacitinib at different doses in adult participants with moderate to severe AD.
Upadacitinib is an approved drug for the treatment of moderate to severe atopic dermatitis (AD). This study is conducted in 2 periods. During Period 1, participants are randomly assigned into 1 of 2 groups called treatment arms to receive upadacitinib Dose A or dupilumab Dose A. Based on the participants response to upadacitinib Dose A, they may have their dose increased to upadacitinib Dose B after 2 weeks. In Period 2, participants that completed Period 1 will either remain on their assigned dose or be reassigned to a different dose based on their Eczema Area and Severity Index (EASI) response. Approximately 300 adult participants ages 18 to 64 with moderate to severe AD who are current users of dupilumab and had a history of inadequate response to dupilumab will be enrolled at up to 94 sites worldwide.
The study is comprised of a 35-day Screening Period, an 8-week Open-Label Period 1 and a 24-week Open-Label Period 2 for participants that completed Period 1. Participants will receive upadacitinib oral tablets once daily or dupilumab subcutaneous (SC) injection every other week for 32 weeks and followed for 30 days.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires. Read Less
Gender:
ALL
Ages:
Between 18 years and 63 years
Trial Updated:
08/19/2025
Locations: Clinical Trials Institute - Northwest Arkansas /ID# 267290, Fayetteville, Arkansas +95 locations
Clinical Trials Institute - Northwest Arkansas /ID# 267290, Fayetteville, Arkansas
Private Practice - Dr. Tooraj Raoof /ID# 263849, Encino, California
Allergy & Asthma Associates of Southern California - Mission Viejo /ID# 266574, Mission Viejo, California
Dermatologist Medical Group of North County- Profound Research /ID# 266512, Oceanside, California
Stanford University School of Medicine - Redwood City /ID# 263776, Redwood City, California
Integrative Skin Science and Research /ID# 264537, Sacramento, California
West Dermatology La Jolla /ID# 265014, San Diego, California
Clinical Trials Research Institute /ID# 263846, Thousand Oaks, California
Yale University School of Medicine /ID# 263836, New Haven, Connecticut
Clearlyderm Dermatology - West Boca /ID# 264923, Boca Raton, Florida
Skin Care Research Boca Raton /ID# 263733, Boca Raton, Florida
Apex Clinical Trials /ID# 263747, Brandon, Florida
TrueBlue Clinical Research /ID# 265037, Brandon, Florida
Life Clinical Trials /ID# 267195, Coral Springs, Florida
Revival Research - Doral /ID# 263541, Doral, Florida
Skin Care Research - Hollywood /ID# 263739, Hollywood, Florida
Solutions Through Advanced Research /ID# 263392, Jacksonville, Florida
GSI Clinical Research, LLC /ID# 263760, Margate, Florida
Quality Research of South Florida /ID# 266496, Miami Lakes, Florida
Research Associates of South Florida /ID# 267291, Miami, Florida
International Dermatology Research /ID# 264961, Miami, Florida
Sullivan Dermatology /ID# 263537, Miami, Florida
Lenus Research and Medical Group /ID# 263779, Miami, Florida
Global Clinical Professionals (GCP) /ID# 266474, Saint Petersburg, Florida
Skin Care Research - Tampa /ID# 263750, Tampa, Florida
Alliance Clinical Research of Tampa /ID# 264531, Tampa, Florida
Centricity Research Columbus Dermatology /ID# 266529, Columbus, Georgia
Cleaver Medical Group Dermatology /ID# 263788, Dawsonville, Georgia
Georgia Skin & Cancer Clinic /ID# 267199, Savannah, Georgia
Treasure Valley Medical Research /ID# 263738, Boise, Idaho
DeNova Research /ID# 264513, Chicago, Illinois
Northwestern University Feinberg School of Medicine /ID# 264983, Chicago, Illinois
Dawes Fretzin, LLC /ID# 264534, Indianapolis, Indiana
Options Research Group /ID# 264564, West Lafayette, Indiana
Dermatology Specialists Research (DS Research) - Kentucky /ID# 263388, Louisville, Kentucky
Velocity Clinical Research at The Dermatology Clinic - Baton Rouge /ID# 267169, Baton Rouge, Louisiana
Boston Specialists /ID# 265810, Boston, Massachusetts
Beth Israel Deaconess Medical Center /ID# 263703, Boston, Massachusetts
Beacon Clinical Research /ID# 263843, Quincy, Massachusetts
Great Lakes Research Group - Bay City /ID# 263535, Bay City, Michigan
Henry Ford Medical Center - New Center One /ID# 263522, Detroit, Michigan
Onyx Clinical Research - Flint - South Linden Road /ID# 267773, Flint, Michigan
MediSearch Clinical Trials /ID# 263579, Saint Joseph, Missouri
Physician Research Collaboration, LLC /ID# 263583, Lincoln, Nebraska
Skin Specialists /ID# 263345, Omaha, Nebraska
Skin Cancer and Dermatology Institute - Reno /ID# 263771, Reno, Nevada
Dartmouth Hitchcock Medical Center - Old Etna Road /ID# 263840, Lebanon, New Hampshire
Forest Hills Dermatology Group @ Union Turnpike /ID# 263755, Kew Gardens, New York
Equity Medical, LLC /ID# 265814, New York, New York
Weill Cornell Medicine /ID# 265793, New York, New York
Piedmont Plastic Surgery and Dermatology /ID# 266545, Huntersville, North Carolina
Vital Prospects Clinical Research Institute - Tulsa /ID# 263645, Tulsa, Oklahoma
Oregon Health and Science University /ID# 263736, Portland, Oregon
Dermatology Partners /ID# 264972, Philadelphia, Pennsylvania
University of Pittsburgh Medical Center /ID# 264526, Pittsburgh, Pennsylvania
Dermatology Associates of Plymouth Meeting /ID# 267286, Plymouth Meeting, Pennsylvania
Medical University of South Carolina /ID# 263655, Charleston, South Carolina
ADCS - Spartanburg /ID# 267185, Spartanburg, South Carolina
Arlington Research Center, Inc /ID# 263665, Arlington, Texas
Orion Clinical Research /ID# 263658, Austin, Texas
Bellaire Dermatology Associates /ID# 263794, Bellaire, Texas
Studies in Dermatology LLC /ID# 263335, Cypress, Texas
Dermatology Treatment and Research Center /ID# 265812, Dallas, Texas
Modern Research Associates /ID# 263852, Dallas, Texas
The Dermatology Institute of South Texas /ID# 267332, McAllen, Texas
Texas Dermatology Research Center /ID# 264528, Plano, Texas
Stride Clinical Research /ID# 267331, Sugar Land, Texas
The Woodlands Dermatology Associates /ID# 266547, The Woodlands, Texas
Dermatology Associates of Tyler /ID# 264980, Tyler, Texas
West Virginia Research Institute - Morgantown /ID# 264930, Morgantown, West Virginia
Dermatology Research Institute - Blackfoot Trail /ID# 270450, Calgary, Alberta
Stratica Medical /ID# 270466, Edmonton, Alberta
Centre de Recherche Saint-Louis /ID# 271083, Québec, Quebec
Centro de Inmunología y Genética CIGE SAS /ID# 266200, Medellín, Antioquia
Centro Integral de Reumatología del Caribe SAS - Circaribe SAS /ID# 265088, Barranquilla, Atlantico
Centro de Investigacion en Reumatologia y especialidades Medicas S.A.S- CIREEM /ID# 265092, Bogotá, Cundinamarca
Unidad Integral de Endocrinologia (UNIENDO) /ID# 266970, Bogotá, Cundinamarca
Ichinomiya Municipal Hospital /ID# 265068, Ichinomiya, Aichi
Takeoka Dermatology Clinic /ID# 264055, Marugame, Kagawa
Kawasaki Medical School Hospital /ID# 266164, Kurashiki, Okayama
Dokkyo Medical University Hospital /ID# 265431, Mibu, Tochigi
Tachikawa Dermatology Clinic /ID# 271912, Tachikawa-shi, Tokyo
Katahira Dermatology Urology Clinic /ID# 264403, Kagoshima, Not set
NTT Medical Center Tokyo /ID# 265104, Tokyo, Not set
Teikyo University Hospital /ID# 265126, Tokyo, Not set
Korea University Ansan Hospital /ID# 263330, Ansan-si, Gyeonggido
Soon Chun Hyang University Hospital Bucheon /ID# 263331, Bucheon-si, Gyeonggido
Ajou University Hospital /ID# 263328, Suwon-si, Gyeonggido
Seoul National University Hospital /ID# 263329, Seoul, Seoul Teugbyeolsi
Konkuk University Medical Center /ID# 263327, Seoul, Seoul Teugbyeolsi
SCB Research Center /ID# 263217, Bayamon, Not set
Private Practice - Dr. Samuel Sanchez /ID# 263199, Caguas, Not set
Private Practice - Dr. Alma Cruz /ID# 263216, Carolina, Not set
Clinical Research Puerto Rico /ID# 263197, San Juan, Not set
GCM Medical Group, PSC /ID# 263218, San Juan, Not set
Caribbean Medical Research Center /ID# 267163, San Juan, Not set
Conditions: Atopic Dermatitis
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