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All Clinical Trials in Canada
A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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A Study of the Efficacy and Safety of Brensocatib in Adults With Moderate to Severe Hidradenitis Suppurativa (HS)
Recruiting
The primary purpose of the study is evaluate the effect of brensocatib compared with placebo.
The primary purpose of the study is evaluate the effect of brensocatib compared with placebo. Read Less
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/19/2025
Locations: USA001, Phoenix, Arizona +67 locations
USA001, Phoenix, Arizona
USA007, Sacramento, California
USA026, Coral Gables, Florida
USA021, Margate, Florida
USA018, Miami, Florida
USA025, Ocala, Florida
USA004, Tampa, Florida
USA010, Weston, Florida
USA011, Sandy Springs, Georgia
USA003, Plainfield, Indiana
USA002, Baton Rouge, Louisiana
USA017, Boston, Massachusetts
USA012, Detroit, Michigan
USA024, Fort Gratiot, Michigan
USA020, Minneapolis, Minnesota
USA015, Saint Louis, Missouri
USA013, Lebanon, New Hampshire
USA009, Cleveland, Ohio
USA016, Springfield, Ohio
USA019, Hershey, Pennsylvania
USA005, Dallas, Texas
USA023, Dallas, Texas
USA008, Spokane, Washington
AUS003, Darlinghurst, New South Wales
AUS004, Kogarah, New South Wales
AUS001, Brisbane, Queensland
AUS002, Fremantle, Western Australia
BGR001, Lovech, Not set
BGR003, Pleven, Not set
BGR004, Sofia, Not set
BGR002, Stara Zagora, Not set
CAN003, Barrie, Ontario
CAN006, Guelph, Ontario
CAN007, Peterborough, Ontario
CAN011, Richmond Hill, Ontario
CAN009, Richmond Hill, Ontario
CAN010, Toronto, Ontario
CAN004, Quebec, Not set
FRA001, Lyon, Auvergne-Rhône-Alpes
FRA004, Toulouse, Haute-Garonne
FRA002, Antony, Not set
FRA003, Paris, Not set
FRA005, Rouen, Not set
DEU007, Langenau, Baden-Württemberg
DEU002, Darmstadt, Hessen
DEU001, Bochum, North Rhine-Westphalia
DEU003, Dresden, Sachsen
DEU006, Dessau-Roßlau, Not set
DEU005, Lubeck, Not set
GRC002, Athina, Attiki
GRC004, Chaidari, Attiki
GRC001, N. Efkapria-Pavlos Melas, Thessaloniki
GRC003, Thessaloniki, Not set
NLD001, Rotterdam, Not set
POL006, Wroclaw, Lower Silesia
POL008, Warsaw, Mazowieckie
POL002, Rzeszów, Podkarpackie
POL004, Kraków, Not set
POL007, Warszawa, Not set
POL001, Warszawa, Not set
POL005, Wroclaw, Not set
POL003, Wrocław, Not set
ESP006, Badalona, Barcelona
ESP004, Las Palmas De Gran Canaria, Las Palmas Provincia
ESP001, Manises, Valencia
ESP002, Madrid, Not set
ESP005, Madrid, Not set
ESP003, Madrid, Not set
Conditions: Hidradenitis Suppurativa
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease
Recruiting
This study is open to adults with chronic kidney disease (CKD) that is at risk of getting worse. People who have taken a specific type of medication for kidney disease called SGLT2 inhibitor within 1 month before the study or have certain health conditions cannot take part in this study. The purpose of this study is to find out whether a medicine called vicadrostat, used in combination with another medicine called empagliflozin, works in people with chronic kidney disease.
In this study, partic... Read More
This study is open to adults with chronic kidney disease (CKD) that is at risk of getting worse. People who have taken a specific type of medication for kidney disease called SGLT2 inhibitor within 1 month before the study or have certain health conditions cannot take part in this study. The purpose of this study is to find out whether a medicine called vicadrostat, used in combination with another medicine called empagliflozin, works in people with chronic kidney disease.
In this study, participants are randomly assigned to one of two groups. Participants have an equal chance of being assigned to either group. In one group, participants take the 2 study medicines, vicadrostat and empagliflozin, every day for 3 months. In the other group, participants take placebo and empagliflozin for the first 1.5 months, and then they take vicadrostat and empagliflozin together for the next 1.5 months. The study medicines are taken orally as tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine.
Participants are in the study for about 4 months. During this time, they visit the study site multiple times. Doctors regularly test kidney function by measuring specific proteins in the blood and urine.
The results are compared between the two groups to see whether there are differences between starting the study medicines at the same time or one after the other. The doctors also regularly check participants' health and take note of any unwanted effects. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Apogee Clinical Research, Huntsville, Alabama +155 locations
Apogee Clinical Research, Huntsville, Alabama
Orange County Clinical Trials, Anaheim, California
North America Research Institute, San Dimas, California
Valiance Clinical Research-Tarzana-68237, Tarzana, California
Amicis Research Center - Valencia, Valencia, California
Focus Clinical Research, West Hills, California
Western Nephrology, Arvada, Arvada, Colorado
Clinical Research of Brandon LLC, Brandon, Florida
Hillcrest Medical Research, DeLand, Florida
Encore Medical Research, Hollywood, Florida
San Marcus Research Clinic, Inc., Miami Lakes, Florida
Finlay Medical Research Corp, Miami, Florida
Total Research Group, LLC, Miami, Florida
West Orange Endocrinology, Ocoee, Florida
Florida Kidney Physicians - Riverview/Brandon, Riverview, Florida
Masters of Clinical Research, Inc, Augusta, Georgia
Velocity Clinical Research, Savannah, Savannah, Georgia
Boise Kidney and Hypertension, PLLC, Boise, Idaho
Research by Design, LLC, Chicago, Illinois
Nephrology Associates of Northern Illinois and Indiana - Oak Brook, Hinsdale, Illinois
Nephrology Associates of Northern Illinois and Indiana - Fort Wayne, Fort Wayne, Indiana
Kansas Nephrology Research Institute, LLC, Wichita, Kansas
LSU Health Sciences Center, New Orleans, Louisiana
Northwest Louisiana Nephrology, Shreveport, Louisiana
Aa Mrc Llc, Flint, Michigan
Michigan Kidney Consultants, Pontiac, Michigan
Sky Clinical Research, Fayette, Mississippi
Midwest Nephrology Associates, Saint Peters, Missouri
Endocrine Associates of Long Island, Smithtown, New York
Durham Nephrology Associates, Durham, North Carolina
Lucas Research, Inc., Morehead City, North Carolina
Brookview Hills Research Associates LLC, Winston-Salem, North Carolina
Heritage Valley Medical Group, Beaver, Pennsylvania
Southeast Renal Research Institute, Chattanooga, Tennessee
Arlington Nephrology, Arlington, Texas
Endocrine Associates, Houston, Texas
Clinical Advancement Center, PLLC, San Antonio, Texas
Javara Inc.-Stephenville-68996, Stephenville, Texas
Utah Kidney Research Institute, Salt Lake City, Utah
Tidewater Physicians Multispecialty Group, Newport News, Virginia
CEDIC - Centro de Investigacion Clinica, Caba, Not set
Mautalen- Salud e Investigacion, Caba, Not set
Sanatorio Güemes, Capital Federal, Not set
IDIM - Instituto de Diagnostico e Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires, Not set
Instituto Medico Catamarca - IMEC, Rosario, Not set
CEMEDIC - Centro de Especialidades Medicas, Villa Luro, Not set
John Hunter Hospital, New Lambton Heights, New South Wales
Westmead Hospital, Westmead, New South Wales
Austin Health, Heidelberg, Victoria
Royal Perth Hospital, Perth, Western Australia
ULB Hopital Erasme, Bruxelles, Not set
Brussels - UNIV Saint-Luc, Bruxelles, Not set
UZ Leuven, Leuven, Not set
Humani - CHU Charleroi - Chimay, Lodelinsart, Not set
Centro de Pesquisa do Hospital Evangélico de Belo Horizonte, Belo Horizonte, Not set
Chronos Pesquisa Clinica, Brasilia, Not set
Galileo Medical Research Ltda, Juiz de Fora, Not set
CEPIC - Centro Paulista de Investigacao Clinica, Sao Paulo, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
Cpquali Pesquisa Clinica Ltda, São Paulo, Not set
Fundação Oswaldo Ramos (Hospital do Rim), São Paulo, Not set
Centro de Pesquisa Clínica de Nefrologia do ICHC, São Paulo, Not set
Bluewater Clinical Research, Sarnia, Ontario
Heart Health Institute (Scarborough), Scarborough, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
Toronto General Hospital, Toronto, Ontario
Diex Recherche (Trois-Rivieres), Trois-Rivieres, Quebec
Beijing Tsinghua Changgung Hospital, Beijing, Not set
West China Hospital of Sichuan University, Chengdu, Not set
NanFang Hosptial, Guangzhou, Not set
Zhejiang Province People's Hospital, Hangzhou, Not set
The Second Hospital of Anhui Medical University, Hefei, Not set
Center Hospital of Jinan, Jinan, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Not set
The First People's Hospital of Nanning, Nanning, Not set
Ningbo Second Hospital, Ningbo, Not set
General Hospital of Ningxia Medical University, Ningxia, Not set
Second Hospital Affiliated to Shantou Medical University, Shantou, Not set
Shenzhen Second People's Hospital, Shenzhen, Not set
First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Not set
Yibin Second People's Hospital, Yibin, Not set
DIKa centrum s.r.o., Havirov, Not set
MILAN KVAPIL s.r.o., Pribram, Not set
Hospital Slany, Internal Department, Slany, Not set
HOP Bicêtre, Le Kremlin-Bicêtre, Not set
HOP Hôtel-Dieu, Nantes, Not set
HOP Civil, Strasbourg, Not set
Klinikum Bielefeld, Bielefeld, Not set
Internistische Gemeinschaftspraxis in Bünde, Bünde, Not set
Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Universitätsklinikum Frankfurt, Frankfurt, Not set
DaVita Clinical Research Germany GmbH Geilenkirchen, Geilenkirchen, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen, Hannover, Not set
Nephrologische Gemeinschaftspraxis, Hamann/Bacinovic/Jacobsen, Rotenburg, Not set
Robert Bosch Gesellschaft für medizinische Forschung mbH, Stuttgart, Not set
DKD Helios Klinik Wiesbaden, Wiesbaden, Not set
Ospedale SS Annunziata, Chieti, Not set
Università degli Studi di Perugia, Perugia, Not set
Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica (BG), Not set
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Not set
Kasugai Municipal Hospital, Aichi, Kasugai, Not set
National Hospital Organization Chibahigashi National Hospital, Chiba, Chiba, Not set
Tsuchiura Kyodo General Hospital, Ibaraki, Tsuchiura, Not set
Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Yokohama, Not set
Osaka General Medical Center, Osaka, Osaka, Not set
Ageo Central General Hospital, Saitama, Ageo, Not set
Omihachiman Community Medical Center, Shiga, Omihachiman, Not set
Tokyo Medical University Hachioji Medical Center, Tokyo, Hachioji, Not set
Korea University Ansan Hospital, Ansan-si, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Not set
Hanyang University Medical Center, Seoul, Not set
Yonsei University Wonju Severance Christian Hospital, Wonju-si, Gangwon State, Not set
Hospital Canselor Tuanku Muhriz, Cheras, Not set
Hospital Sultan Idris Shah Serdang, Kajang, Not set
Tuanku Fauziah Hospital, Kangar, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
Amsterdam UMC Locatie AMC, Amsterdam, Not set
Albert SchweitzerZiekenhuis, Dordrecht, Not set
Catharina Ziekenhuis, Eindhoven, Not set
Bethesda Diabetes Research Center, Hoogeveen, Hoogeveen, Not set
Momentum Clinical Research - Kapiti Coast, Kapiti, Wellington Region
Dunedin Hospital, Dunedin, Not set
Waikato Hospital, Hamilton, Not set
Senor Santo Nino Hospital, Camiling, Not set
Norzel Medical and Diagnostic Clinic, Cebu City, Not set
Institute for Studies on Diabetes Foundation Inc., Marikina City, Not set
Philippine Heart Center, Quezon City, Not set
Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk, Bydgoszcz, Not set
American Heart Of Poland Sp. Z O.O., Chrzanow, Not set
Pro Familia Altera Sp. z o.o., Katowice, Not set
Pro Salus Sp. z o.o. sp.k., Lodz, Not set
FDI Clinical Research - Mayagüez, Mayaguez, Not set
Centro de Salud Milladoiro, A Coruña, Not set
C.A.P. Sardenya, Barcelona, Not set
Centro de Salud Cartagena Casco Antiguo, Cartagena, Not set
Eap Osona Sud Alt Congost S.L.P. Cap Centelles, Centelles, Barcelona, Not set
Centro de Salud Naranco, Oviedo, Not set
Centro de Salud de San Juan, Salamanca, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Mackay Memorial Hospital, Taipei, Not set
King Chulalongkorn Memorial Hospital, Bangkok, Not set
Phramongkutklao Hospital, Bangkok, Not set
Siriraj Hospital, Bangkok, Not set
Maharaj Nakom Chiangmai Hospital, Chiang Mai, Not set
University Hospital Monklands, Airdrie, Not set
Banbury Cross Health Centre, Banbury, Not set
Queen Elizabeth University Hospital, Glasgow, Not set
Belmont Health Centre, Harrow, Not set
Velocity Clinical Research, High Wycombe, High Wycombe, Not set
Richford Gate Medical Practice, London, Not set
Royal Berkshire Hospital, Reading, Not set
Sunderland Royal Hospital, Sunderland, Not set
Conditions: Chronic Kidney Disease
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
Recruiting
This study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medicine called nerandomilast or BI 1015550.
The goal of this study is to find out how well people with pulmonary fibrosis tolerate long- term treatment with nerandomilast. The study also tests whether nerandomilast improves lung function and prolongs the time until symptoms get worse, participants need... Read More
This study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medicine called nerandomilast or BI 1015550.
The goal of this study is to find out how well people with pulmonary fibrosis tolerate long- term treatment with nerandomilast. The study also tests whether nerandomilast improves lung function and prolongs the time until symptoms get worse, participants need to go to the hospital, or die.
Every participant takes nerandomilast as tablets for up to 1 year and 10 months. The participants may also continue their regular treatment for pulmonary fibrosis during the study.
Participants visit their doctors regularly. During these visits, the doctors collect information on any health problems of the participants. Participants also regularly do lung function tests. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +370 locations
University of Alabama at Birmingham, Birmingham, Alabama
University of Arizona, Tucson, Arizona
University of Southern California, Los Angeles, California
Cedars-Sinai Medical Center, Los Angeles, California
University of California Los Angeles, Los Angeles, California
University of California Davis, Sacramento, California
National Jewish Health, Denver, Colorado
Yale University School of Medicine, New Haven, Connecticut
Christiana Hospital, Newark, Delaware
Georgetown University, Washington, District of Columbia
St. Francis Medical Institute, Clearwater, Florida
University of Florida, Gainesville, Florida
Clinical Research Specialists LLC, Kissimmee, Florida
Advanced Pulmonary Research Institute, Loxahatchee Groves, Florida
Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead, Atlanta, Georgia
The Emory Clinic, Atlanta, Georgia
Northshore University Health System, Evanston, Illinois
University of Kansas Medical Center, Kansas City, Kansas
Tulane Medical Center, New Orleans, Louisiana
Johns Hopkins Hospital, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
St. Elizabeth's Medical Center, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
University of Michigan Health System, Ann Arbor, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
University of Minnesota, Minneapolis, Minnesota
Mayo Clinic, Rochester, Rochester, Minnesota
The Lung Research Center, LLC, Chesterfield, Missouri
Creighton University, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Renown Regional Medical Center, Reno, Nevada
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Northern Westchester Hospital, Mount Kisco, New York
Columbia University Medical Center-New York Presbyterian Hospital, New York, New York
NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York
Duke University Medical Center, Durham, North Carolina
Southeastern Research Center-Winston Salem-69289, Winston-Salem, North Carolina
University of Cincinnati, Cincinnati, Ohio
Cleveland Clinic, Cleveland, Ohio
The Ohio State University Wexner Medical Center, Columbus, Ohio
The Oregon Clinic, Portland, Oregon
University of Pennsylvania, Philadelphia, Pennsylvania
Temple University Hospital, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
Infinity Medical Research, Inc., East Providence, Rhode Island
Lowcountry Lung and Critical Care, Charleston, South Carolina
Clinical Trials Center of Middle Tennessee, LLC, Franklin, Tennessee
Vanderbilt University Medical Center, Nashville, Tennessee
Baylor University Medical Center, Dallas, Texas
UT Health San Antonio, San Antonio, Texas
Intermountain Medical Center-Murray-69497, Murray, Utah
University of Utah Health Sciences Center, Salt Lake City, Utah
University of Vermont, Burlington, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Virginia Mason Medical Center, Seattle, Washington
University of Wisconsin, Madison, Wisconsin
Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553, C.a.b.a, Not set
CEDIC - Centro de Investigacion Clinica, Caba, Not set
Hospital Italiano de Buenos Aires, Caba, Not set
Consultorios Médicos del Buen Ayre, Capital Federal, Not set
CEMER-Centro Medico De Enfermedades Respiratorias, Florida, Not set
Instituto Ave Pulmo, Mar del Plata, Not set
INSARES, Mendoza, Not set
Centro Respiratorio de Quilmes, Quilmes, Not set
Instituto Médico de la Fundación Estudios Clínicos, Rosario, Not set
Canberra Hospital, Garran, Australian Capital Territory
Royal Prince Alfred Hospital, Camperdown, New South Wales
Westmead Hospital, Westmead, New South Wales
Lung Research Queensland, Chermside, Queensland
The Prince Charles Hospital, Chermside, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Austin Hospital, Heidelberg, Victoria
The Alfred Hospital, Melbourne, Victoria
Fiona Stanley Hospital, Murdoch, Western Australia
Trialswest, Spearwood, Western Australia
Macquarie University, Macquarie Park, Not set
Krems University Hospital, Krems, Not set
LKH Salzburg University Hospital, Salzburg, Not set
AKH - Medical University of Vienna, Vienna, Not set
Clinic Floridsdorf, Vienna, Not set
Klinikum Wels - Grieskirchen GmbH, Wels, Not set
Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim, Antwerpen, Not set
ULB Hopital Erasme, Bruxelles, Not set
Brussels - UNIV Saint-Luc, Bruxelles, Not set
UNIV UZ Gent, Gent, Not set
UZ Leuven, Leuven, Not set
Centre Hospitalier Universitaire de Liège, Liège, Not set
Yvoir - UNIV UCL de Mont-Godinne, Yvoir, Not set
Serviços Medicos Respirar Sul Fluminense, Barra Mansa, Not set
Hospital das Clinicas da Universidade Federal HC-UFMG, Belo Horizonte,Minas Gerais, Not set
Edumed - Educacao e Saude SA, Curitiba, Not set
CLARE - Clinica de Pneumologia, Goiania, Not set
Hospital Nossa Senhora da Conceição, Porto Alegre - RS, Not set
Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
CEMEC - Centro Multidisciplinar de Estudos Clínicos, São Bernardo do Campo, Not set
Hospital das Clinicas da FMUSP, São Paulo, Not set
University of Alberta Hospital (University of Alberta), Edmonton, Alberta
Kelowna Respirology & Allergy Research, Kelowna, British Columbia
St. Paul's Hospital (Vancouver), Vancouver, British Columbia
Vancouver General Hospital, Vancouver, British Columbia
Dr. Georges-L.-Dumont University Hospital Centre, Moncton, New Brunswick
QEII Health Sciences Centre, Halifax, Nova Scotia
St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Dr. Syed Anees Medicine Professional Corporation, Windsor, Ontario
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec
McGill University Health Centre (MUHC), Montreal, Quebec
CIC Mauricie Inc., Trois-Rivieres, Quebec
Royal University Hospital (Saskatoon), Saskatoon, Saskatchewan
IUCPQ (Laval University), Quebec, Not set
Instituto Nacional del Tórax, Providencia, Santiago De Chile, Not set
Centro de Investigación del Maule, Talca, Not set
Beijing Chao-Yang Hospital, Beijing, Not set
China-Japan Friendship Hospital, Beijing, Not set
Peking Union Medical College Hospital, Beijing, Not set
The Second Xiangya Hospital Of Central South University, Changsha, Not set
West China Hospital of Sichuan University, Chengdu, Not set
People's Hospital of Sichuan Province, Chengdu, Not set
First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
NanFang Hosptial, Guangzhou, Not set
Hangzhou First People's Hospital, Hangzhou, Not set
The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Not set
Zhejiang Hospital, Hangzhou, Not set
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Not set
Anhui Provincial Hospital, Hefei, Not set
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Not set
The First hospital of Jiaxing, Jiaxing, Not set
Jinhua Municipal Central Hospital, Jinhua, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Ningbo Medical Center Lihuili Hospital, Ningbo, Not set
The First Affiliated Hospital of Ningbo University, Ningbo, Not set
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Not set
Shanghai Chest Hospital, Shanghai, Not set
Zhongshan Hospital Affiliated to Fudan University, Shanghai, Not set
Huadong Hospital affiliated to Fudan University, Shanghai, Not set
China Shenyang Chest Hospital, Shenyang, Not set
Shenzhen People's Hospital, Shenzhen, Not set
The University of Hong Kong-Shenzhen Hospital, Shenzhen, Not set
The First Affiliated Hospital of Soochow University, Suzhou, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
The First Affiliated Hospital of Wenzhou Med College, Wenzhou, Not set
Wuhan Union Hospital, Wuhan, Not set
Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T, Wuhan, Not set
Renmin Hospital of Wuhan University, Wuhan, Not set
Wuxi People's Hospital, Wuxi, Not set
Second Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Not set
Affiliated Hospital, Xuzhou Medical college, Xuzhou, Not set
Yichang NO.1 People's Hospital, Yichang, Not set
General Hospital of Ningxia Medical University, Yinchuan, Not set
University hospital center Zagreb, Zagreb, Not set
University Hospital Dubrava, Zagreb, Not set
Solmed Polyclinic, Zagreb, Not set
Thomayer University Hospital, Praha 4, Not set
Gentofte Hospital, Hellerup, Not set
Odense University Hospital, Odense C, Not set
North Estonia Medical Centre Foundation, Tallinn, Tallinn, Not set
HYKS Keuhkosairauksien tutkimusyksikkö, Helsinki, Not set
Oulun yliopistollinen keskussairaala, Oulu, Not set
Tampere University Hospital, Tampere, Not set
TYKS, Turku, Not set
HOP d'Angers, Angers, Not set
HOP Avicenne, Bobigny, Not set
HOP de la Cavale Blanche, Brest, Not set
HOP Louis Pradel, Bron, Not set
HOP CHU Caen, Caen, Not set
HOP François Mitterrand, Dijon, Not set
HOP Michallon, La Tronche, Not set
HOP Bicêtre, Le Kremlin-Bicêtre, Not set
INS Coeur Poumon, Lille, Not set
HOP Nord, Marseille, Not set
HOP Nord Laennec, Nantes, Not set
HOP Pasteur, Nice, Not set
HOP Paris Saint-Joseph, Paris, Not set
HOP Européen G. Pompidou, Paris, Not set
HOP Bichat, Paris, Not set
HOP Haut-Lévêque, Pessac, Not set
HOP Robert Debré, Reims, Not set
HOP Pontchaillou, Rennes, Not set
HOP Charles Nicolle, Rouen, Not set
HOP Foch, Suresnes, Not set
HOP Larrey, Toulouse, Not set
National Center for Tuberculosis and Lung Diseases, Tbilisi, Tbilisi, Not set
LLC Diacor, Tbilisi, Not set
LTD The First Medical Center, Tbilisi, Not set
Velocity Clinical Research Germany GmbH, Ahrensburg, Ahrensburg, Not set
CIMS Studienzentrum Bamberg GmbH, Bamberg, Not set
Vivantes Netzwerk für Gesundheit GmbH, Berlin, Not set
Universitätsklinikum Bonn AöR, Bonn, Not set
Fachkrankenhaus Coswig GmbH, Coswig, Not set
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH, Essen, Not set
Universitätsklinikum Hamburg, Eppendorf, Hamburg, Not set
Klinikum Region Hannover GmbH, Hannover, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg, Heidelberg, Not set
Lungenklinik Hemer, Hemer, Not set
Lungenfachklinik Immenhausen, Immenhausen, Not set
Klinikum Konstanz, Konstanz, Not set
Klinikum der Universität München AÖR, München, Not set
Klinikum Nürnberg, Nürnberg, Not set
Krankenhaus Bethanien gGmbH, Solingen, Not set
Helios Hanseklinikum Stralsund, Stralsund, Not set
Robert Bosch Gesellschaft für medizinische Forschung mbH, Stuttgart, Not set
Universitätsklinikum Tübingen, Tübingen, Not set
Hospital of Heraklion (PAGNI), Heraclion, Not set
Univ. Gen. Hosp. of Ioannina, Ioannina, Not set
Univ. Gen. Hosp. of Patras, Patras, Not set
General Hospital of Thessaloniki "Hippokrateio", Thessaloniki, Not set
Semmelweis University, Budapest, Not set
Koranyi National Institute For Pulmonolgy, Budapest, Not set
University of Debrecen Clinical Centre, Debrecen, Not set
Bhatia Hospital, Mumbai, Not set
P.D. Hinduja National Hospital, Mumbai, Not set
Connolly Hospital Blanchardstown, Dublin 15, Not set
Shamir Medical Center (Assaf Harofeh), Beer Yaakov, Not set
Lady Davis Carmel Medical Center, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem 91031, Jerusalem, Not set
Sourasky Medical Center, Tel Aviv, Not set
ASST degli Spedali Civili di Brescia, Brescia, Not set
A.O.U. Policlinico Vittorio Emanuele, Catania, Not set
A. O. Universitaria Careggi, Firenze, Not set
Ospedale Colonnello D Avanzo, Foggia, Not set
Ospedale G.B. Morgagni, Forli', Not set
Ospedale San Paolo-MILANO-18793, Milano, Not set
Ospedale Classificato San Giuseppe, Milano, Not set
Azienda Ospedaliera Policlinico di Modena, Modena, Not set
A.O. San Gerardo di Monza, Monza, Not set
Azienda Ospedaliera Universitaria di Padova, Padova, Not set
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Not set
A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena, Not set
Ospedali Riuniti di Ancona, Torrette Di Ancona (Ancona), Not set
Tosei General Hospital, Aichi, Seto, Not set
Chiba University Hospital, Chiba, Chiba, Not set
University of Fukui Hospital, Fukui, Yoshida-gun, Not set
National Hospital Organization Kyushu Medical Center, Fukuoka, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Fukuoka, Not set
Aso Co.,Ltd Iizuka Hospital, Fukuoka, Iizuka, Not set
Hospital of the University of Occupational and Environmental Health, Fukuoka, Kitakyushu, Not set
Kurume University Hospital, Fukuoka, Kurume, Not set
Fukushima Medical University Hospital, Fukushima, Fukushima, Not set
Tsuboi Hospital, Fukushima, Koriyama, Not set
Hiroshima Prefectural Hospital, Hiroshima, Hiroshima, Not set
Sapporo Medical University Hospital, Hokkaido, Sapporo, Not set
Hokkaido University Hospital, Hokkaido, Sapporo, Not set
National Hospital Organization Himeji Medical Center, Hyogo, Himeji, Not set
Kobe City Medical Center General Hospital, Hyogo, Kobe, Not set
Kobe City Hospital Organization Kobe City Medical Center West Hospital, Hyogo, Kobe, Not set
Kagawa University Hospital, Kagawa, Kita-gun, Not set
Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Yokohama, Not set
Saiseikai Kumamoto Hospital, Kumamoto, Kumamoto, Not set
Tohoku University Hospital, Miyagi, Sendai, Not set
Nagasaki University Hospital, Nagasaki, Nagasaki, Not set
Kindai University Hospital, Osaka, Osakasayama, Not set
National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Sakai, Not set
Osaka Medical and Pharmaceutical University Hospital, Osaka, Takatsuki, Not set
Saitama Red Cross Hospital, Saitama, Saitama, Not set
Shimane University Hospital, Shimane, Izumo, Not set
Hamamatsu University Hospital, Shizuoka, Hamamatsu, Not set
Jichi Medical University Hospital, Tochigi, Shimotsuke, Not set
Tokushima University Hospital, Tokushima, Tokushima, Not set
Juntendo University Hospital, Tokyo, Bunkyo-ku, Not set
Nippon Medical School Hospital, Tokyo, Bunkyo-ku, Not set
Toranomon Hospital, Tokyo, Minato-ku, Not set
Kyorin University Hospital, Tokyo, Mitaka, Not set
Toho University Omori Medical Center, Tokyo, Ota-ku, Not set
Tokyo Medical University Hospital, Tokyo, Shinjuku-ku, Not set
Keio University Hospital, Tokyo, Shinjuku-ku, Not set
National Center for Global Health and Medicine, Tokyo, Shinjuku-ku, Not set
Wakayama Medical University Hospital, Wakayama, Wakayama, Not set
The Catholic University of Korea, Bucheon St.Mary's Hospital, Bucheon, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
Kyung Hee University Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
Soonchunhyang University Hospital Seoul, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Hospital Pulau Pinang-Pulau Pinang-21953, George Town, Not set
Hospital Sultan Idris Shah Serdang, Kajang, Not set
Institut Perubatan Respiratori, Kuala Lumpur, Not set
Sarawak General Hospital, Kuching, Not set
Centro de Investigacion Integral MEDIVEST S.C, Chihuahua, Not set
Soltmed Smo, Ciudad de Mexico, Not set
Centro Respiratorio de Mexico, Ciudad de Mexico, Not set
CREPID Aire y Salud, Coyoacan, Not set
Centro de Investigacion Farmacologica del Bajío, S.C., Guanajuato, Not set
Centro de Prevención y Rehabilitación de Enfermedades Pulmon, Monterrey, Not set
Oaxaca Site Management Organization, S.C., Oaxaca, Not set
Zuyderland Medisch Centrum, HEERLENHeerlen, Not set
Leids Universitair Medisch Centrum (LUMC), Leiden, Not set
St. Antonius ziekenhuis, locatie Nieuwegein, Nieuwegein, Not set
Erasmus Medisch Centrum-ROTTERDAM-50697, Rotterdam, Not set
Waikato Hospital, Hamilton, Not set
Greenlane Clinical Centre, One Tree Hill, Auckland, Not set
Tauranga Hospital, Tauranga South, Not set
Haukeland Universitetssykehus, Bergen, Not set
Akershus Universitetssykehus HF, Nordbyhagen, Not set
Oslo Universitetssykehus HF, Rikshospitalet, Oslo, Not set
University Clinical Center, Gdansk, Gdansk, Not set
Leszek Giec Upper-Silesian Med.Cent.Silesian Med.Univ., Katowice, Not set
Alergopneuma Medical Center, Swidnik, Not set
Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa, Warsaw, Not set
University Clinical Center of the Medical University of Warsaw, Warsaw, Not set
ULS Braga, Braga, Not set
ULS de Coimbra, E.P.E., Coimbra, Not set
ULS de São José, E.P.E., Lisboa, Not set
USLM, EPE - Hospital Pedro Hispano, Matosinhos, Not set
ULS de Gaia/Espinho, EPE, Vila Nova de Gaia, Not set
King Abdullah International Medical Research Center, Riyadh, Not set
University Clinical Center of Serbia, Belgrade, Not set
University Clinical Center Nis, Nis, Not set
Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Not set
Singapore General Hospital, Singapore, Not set
Tan Tock Seng Hospital, Singapore, Not set
Hospital Golnik - Univ. Clinic of Pulmonary and Allergic Diseases, Golnik, Not set
Enhancing Care Foundation NPC, Mount Edgecombe, Not set
Hospital General Universitario de Alicante, Alicante, Not set
Hospital del Mar, Barcelona, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital de Basurto, Bilbao, Not set
Hospital Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital de Galdakao, Galdakao, Not set
Hospital Universitario Virgen de las Nieves, Granada, Not set
Hospital de Bellvitge, L'Hospitalet de Llobregat, Not set
Hospital La Princesa, Madrid, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Universitario Infanta Leonor, Madrid, Not set
Hospital Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Virgen de la Victoria, Malaga, Not set
Hospital Central de Asturias, Oviedo, Not set
Hospital Son Espases, Palma de Mallorca, Not set
Hospital Quirónsalud Madrid, Pozuelo de Alarcón, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Clínico de Santiago, Santiago de Compostela, Not set
Hospital Virgen del Rocío, Sevilla, Not set
Hospital Nuestra Señora de Valme, Sevilla, Not set
Hospital General Universitario de Valencia, Valencia, Not set
Universitetssjukhuset, Linköping, Linköping, Not set
Akademiska sjukhuset, Uppsala, Not set
Universitätsspital Basel, Basel, Not set
Chang-Hua Christian Hospital, Changhua, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Taichung Veterans General Hospital, Taichung, Not set
NCKUH, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Siriraj Hospital, Bangkok Noi, Not set
Srinagarind Hospital, Khon Kaen, Not set
Maharat Nakhonchiangmai Hospital, Muang, Not set
Ramathibodi Hospital, Ratchatewi, Not set
Songklanagarind Hospital, Songkhla, Not set
Gulhane Training and Research Hospital, Ankara, Not set
Ankara Universitesi Tip Fakultesi, Ankara, Not set
Akdeniz Universitesi Tip Fakultesi -ANTALYA-33606, Antalya, Not set
Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, Not set
Gazi Universitesi Tip Fakultesi, Yenimahalle/ANKARA, Not set
Aberdeen Royal Infirmary, Aberdeen, Not set
Queen Elizabeth Hospital Birmingham, Birmingham, Not set
Southmead Hospital, Bristol, Not set
Royal Infirmary of Edinburgh, Edinburgh, Not set
Royal Devon and Exeter Hospital, Wonford, Exeter, Not set
Royal Lancaster Infirmary, Lancaster, Not set
St James's University Hospital, Leeds, Not set
Altnagelvin Area Hospital, Londonderry, Not set
Guy's Hospital, London, Not set
Royal Brompton Hospital, London, Not set
Wythenshawe Hospital, Manchester, Not set
Churchill Hospital, Oxford, Not set
Southampton General Hospital, Southampton, Not set
Conditions: Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Recruiting
The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) inhibitor (physician's choice of either Durvalumab or Pembrolizumab, where approved under local regulations) as first line of treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive biliary tract cancer.
The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) inhibitor (physician's choice of either Durvalumab or Pembrolizumab, where approved under local regulations) as first line of treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive biliary tract cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Rocky Mountain Cancer Centers, LLP, Lone Tree, Colorado +174 locations
Rocky Mountain Cancer Centers, LLP, Lone Tree, Colorado
AdventHealth Hematology and Oncology, Orlando, Florida
Winship Cancer Institute, Atlanta, Georgia
The University of Kansas Cancer Center - Westwood, Westwood, Kansas
Norton Cancer Institute - Audubon, Louisville, Kentucky
Ochsner Clinic Foundation, New Orleans, Louisiana
Tufts Medical Center, Boston, Massachusetts
University of Michigan Hospital, Ann Arbor, Michigan
Henry Ford Health System, Detroit, Michigan
Minnesota Oncology Hematology, P.A., Maple Grove, Minnesota
Atlantic Health System/Morristown Medical Center, Morristown, New Jersey
Laura and Isaac Perlmutter Cancer Center at NYU Langone - Ambulatory Care Center, New York, New York
Memorial Sloan Kettering Cancer Centers, New York, New York
Saint Francis Cancer Center, Greenville, South Carolina
SCRI Oncology Partners, Nashville, Tennessee
Texas Oncology - DFW, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
The Univerrsity of Texas MD Anderson Cancer Center, Houston, Texas
Virginia Commonwealth University, VCU Health, Richmond, Virginia
Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires (CABA), Buenos Altes
Fundación ARS Médica, San Salvador De Jujuy, Jujuy
Centro de Investigaciónes Clínicas - Clínica Viedma, Viedma, Río Negro
Hospital Provincial Del Centenario, Rosario, Santa Fe
Instituto Médico de la Fundación Estudios Clínicos, Rosario, Santa Fe
CAIPO Centro para la Atención Integral del Paciente Oncológico, San Miguel De Tucumán, Tucumán
Centro Médico en Oncología Clínica EXELSUS S.R.L, San Miguel De Tucumán, Tucumán
Centro Médico Privado CEMAIC, Córdoba, Not set
Imelda VZW, Bonheiden, Antwerpen
UZ Antwerpen, Edegem, Antwerpen
UZ Leuven, Leuven, Vlaams-Brabant
Liga Norte Riograndense Contra O Cancer, Natal, Rio Grande Do Norte
Irmandade Da Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegrev, Rio Grande Do Sul
Hospital de Clinicas de Porto Alegre - HCPA, Porto Alegre, Rio Grande Do Sul
Fundação Pio XII Hospital de Amor de Barretos, Barretos, São Paulo
Fundação Doutor Amaral Carvalho - Hospital Amaral Carvalho, Jaú, São Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto (FUNFARME), São José do Rio Preto, São Paulo
Hospital Nossa Senhora Da Conceição/Centro Integrado de Pesquisa em Oncologia CIPO-GHC, Porto Alegre, Not set
Instituto Nacional de Cancer - INCA, Rio de Janeiro, Not set
London Health Sciences Centre, LondonO, Ontario
Princess Margaret Cancer Centre - University Health Network, Toronto, Ontario
James Lind Centro de Investigacion del Cancer, Temuco, Araucanía
Servicios Médicos URUMED SpA, Rancagua, Libertador Gen Bernardo O Higgins
Clinica Puerto Montt, Puerto Montt, Los Lagos
Fundación Arturo López Pérez (FALP), Santiago, Metropolitana
Oncovida, Santiago, Metropolitana
Hospital Clinico Universidad de Chile, Santiago, Region Metropolitana
Centro de Investigacion y Especialidades Medicas (CDIEM), Santiago, Región-Metropolitana
Biocinetic Ltda, Santiago, Región-Metropolitana
Hunan Provincial People's Hospital, Changsha, Hunan
Jilin Cancer Hospital, Changchun, Jilin
Shandong Provincial Third Hospital, Jinan, Shandong
Sichuan Cancer Hospital, Chengdu, Sichuan
West China Hospital Sichuan University, Chengdu, Sichuan
Fakultní nemocnice Brno, Interní hematologická a onkologická klinika, Brno, Not set
Fakultni nemocnice Hradec Kralove, Klinika onkologie a radioterapie, Hradec Kralove, Not set
Fakultni nemocnice v Motole, Onkologicka klinika, Praha 5, Not set
Docrates Cancer Center, Helsinki, Not set
Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Not set
Kuopio University Hospital, Kuopio, Not set
CHU de Toulouse- (Toulouse University Hospital Center), Toulouse, Cedex 9
CHU Besancon, Besançon, Cedex
CHU de Bordeaux - Hôpital Haut Leveque, Pessac, Cedex
CHU Brest Hôpital de la Cavale Blanche, Brest, Not set
CHU Estaing, Clermont-Ferrand, Not set
Hospital Beaujon University, Clichy, Not set
Hopital Henri Mondor, Créteil, Not set
CHU Montepellier - Hôpital Saint Eloi, Montpellier, Not set
CHU Poitiers, Poitiers, Not set
Institut de Cancérologie de l'Ouest, Saint-Herblain Cedex, Not set
Gustave Roussy, Villejuif Cedex, Not set
Universitätsklinikum Tübingen - Medizinische Universitätsklinik, Innere Medizin I, Tuebingen, Baden-Wuttemberg
Universitätsklinikum Freiburg - Klinik für Innere Medizin II,, Freiburg, Baden-Württemberg
Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg, Heidelberg, Baden-Württemberg
LMU Universitätsklinikum München, Campus Großhadern, Medizinische Klinik und Poliklinik III - Hämatologie und Onkologie, München, Bayern
Krankenhaus Nordwest - Institut für Klinisch-Onkologische Forschung (IFK), Frankfurt, Hessen
Medizinische Hochschule Hannover - Klinik Fur Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie, Hannover, Nieder-Sachsen
Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus, Dresden, Sachsen
Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Medizinische Klinik I (MKI), Lubeck, Schleswig-Holstein
Charité - Universitätsmedizin Berlin - Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt Hamatologie und Tumorimmunologie, Berlin, Not set
Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona - Onkologie und Palliativmedizin mit Sektionen Hamatologie und Rheumatologie, Hamburg, Not set
KLES Dr Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka
Tata Memorial Hospital, Mumbai, Maharashtra
Chopda Medicare & Research Centre Pvt. Ltd - Magnum Heart Institute, Nashik, Maharashtra
AIG Hospitals (A Unit of Asian Institute of Gastroenterology), Hyderabad, Telangana
Pi Health Cancer Hospital, Hyderabad, Telangana
Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, Uttar Pradesh
Max Super Speciality Hospital - Saket (a unit of Devki Devi foundation), New Delhi, Not set
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Not set
Rambam Health Care Campus, Haifa, Not set
The Hadassah University Medical Center, Ein Kerem Hospital, Jerusalem, Not set
Rabin Medical Center, Bellinson Hospital, Petah-Tikva, Not set
The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, HaMerkaz, Not set
Tel Aviv Sourasky Medical Center (Ichilov), Tel Aviv, Not set
Azienda Ospedaliero Universitaria di Cagliari Presidio Ospedaliero Duilio Casula, Monserrato, Cagliari
Instituo di Candiolo, Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo, Torino
IRCCS Ospedale Policlinico San Martino, Genova, Not set
Fondazione IRCCS Istituto Nazionale per lo studio e la cura dei Tumori, Milano, Not set
AOU dell'Universit~ degli Studi della Campania Luigi Vanvitelli, Napoli, Not set
Veneto Institute of Oncology IOV - I.R.C.C.S., Padova, Not set
Azienda Ospedaliero - Universitaria Pisana, Pisa, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Azienda Sanitaria Universitaria Friuli Centrale - P.O. S. Maria della Misericordia, Udine, Not set
Azienda Ospedaliera Universitaria Integrata Verona, Verona, Not set
Aichi Cancer Center, Nagoya-shi, Aichi
Chiba Cancer Center, Chiba-shi, Chiba
National Cancer Center Hospital East, Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center, Matsuyama-Shi, Ehime
National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Fukuoka
Hokkaido University Hospital, Sapporo-Shi, Hokkaidô
Kanazawa University Hospital, Kanazawa-shi, Isikawa
Kagoshima University Hospital, Kagoshima-shi, Kagoshima
Kanagawa Cancer Center, Yokohama-shi, Kanagawa
Kyoto University Hospital, Kyoto City, Kyôto
Mie University Hospital, Tsu-Shi, Mie
Tohoku University Hospital, Sendai-Shi, Miyagi
Niigata University Medical and Dental Hospital, Niigata-shi, Niigata
Osaka Prefectural Hospital Organization Osaka International Cancer Institute, Osaka-shi, Osaka
The University of Tokyo Hospital, Bunkyo-ku, Tokyo
National Cancer Center Hospital, Chuo-Ku, Tokyo
The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Koto-Ku, Tokyo
Kyorin University Hospital, Mitaka-shi, Tokyo
Yamaguchi University Hospital, Ube-Shi, Yamaguchi
Osaka University Hospital, Suita-Shi, Ôsaka
CHA Bundang Medical Center, CHA University, Bundang-Gu, Seongnam-Si, Gyeonggi-do
National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do
Pusan National University Hospital, Busan, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Hanyang University Seoul Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Unidade Local de Saude de Almada-Seixal, E.P.E. - Hospital Garcia de Orta, Almada, Not set
Unidade Local de Saude de Coimbra, EPE - Hospitais da Universidade de Coimbra, Coimbra, Not set
Unidade Local de Saúde de São José - Hospital de Santo António dos Capuchos, Lisboa, Not set
Champalimaud Clinical Center, Lisboa, Not set
Instituto Português de Oncologia Do Porto Francisco Gentil, EPE, Porto, Not set
Hospital Oncologico, Puerto Rico Medical Center, Rio Piedras, Not set
Spital Clinic Judetean de Urgenta Bihor, Oradea, Bihor
Centrul De Oncologie "SF. Nectarie" S.R.L., Craiova, Dolj
Institutul Clinic Fundeni, Bucharest, Not set
Centrul de Oncologie Euroclinic SRL, Iasi, Not set
University Clinical Center of Serbia, Clinic for Gastroenterohepatology, Belgrade, Not set
Military Medical Academy, Clinic for Gastroenterology and Hepatology, Belgrade, Not set
Oncology Institute of Vojvodina, Internal Oncology Clinic, Sremska Kamenica, Not set
Complejo Hospitalario Universitario de Santiago -Hospital Clinico Universitario de Santiago, Santiago de Compostela, A Coruna
Vall d'Hebron Institute of Oncology/Hospital Universitari de Vall d'Hebron, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Malaga, Malaga, Not set
Clinica Universidad de Navarra, Pamplona, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario y Politecnico La Fe, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Onkologiska mottagningen, Sahlgrenska Universitetssjukhuset, Göteborg, Not set
Cancerstudieenheten Huddinge, Karolinska Universitetssjukhuset Huddinge, Huddinge, Not set
Onkologiska mottagningen, Skånes Universitetssjukhus Malmö, Malmö, Not set
Kaohsiung Medical University - Chung-Ho Memorial Hospital, Kaohsiung, Not set
Chang Gung Memorial Hospital Kaohsiung Branch of the Chang Gung Medical Foundation, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Cancer Center, Taipei, Not set
Chang Gung Memorial Hospital Linkou Branch of the Chang Gung Medical Foundation, Taoyuan, Not set
Istanbul University Cerrahpasa Medical Faculty Hospital/Clinical Research Center, Istanbul, Fatih
Hacettepe University Cancer Institute, Ankara, Sihhiye
Akdeniz University Medical Faculty Hospital, Antalya, Not set
Trakya University Faculty of Medicine, Edirne, Not set
Mount Vernon Cancer Centre, London, England
NHS Foundation Trust Royal Marsden Hospital, London, England
The Christie NHS Foundation Trust, Manchester, England
Royal Marsden Hospital NHS Foundation Trust, Surrey, England
Western General Hospital, Edinburgh Cancer Centre, Edinburgh, Scotland
Conditions: Biliary Tract Cancer
Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic (1-3 Metastases) Cancer
Recruiting
Stereotactic Ablative Radiotherapy (SABR) is a modern RT technique that delivers high doses of radiation to small tumor targets using highly conformal techniques. SABR is non-invasive and delivered on an outpatient basis. The purpose of this study is to compare the effect of SABR, relative to standard of care (SOC) alone, on overall survival, progression-free survival, toxicity, and quality of life. An integrated economic evaluation will determine the cost per quality of life year gained using S... Read More
Stereotactic Ablative Radiotherapy (SABR) is a modern RT technique that delivers high doses of radiation to small tumor targets using highly conformal techniques. SABR is non-invasive and delivered on an outpatient basis. The purpose of this study is to compare the effect of SABR, relative to standard of care (SOC) alone, on overall survival, progression-free survival, toxicity, and quality of life. An integrated economic evaluation will determine the cost per quality of life year gained using SABR (vs. SOC) and a translational component will enable identification of predictive/prognostic biomarkers of the oligometastatic state. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Cancer Care Griffith, Griffith, New South Wales +16 locations
Cancer Care Griffith, Griffith, New South Wales
Riverina Cancer Care Centre, Wagga Wagga, New South Wales
Alfred Hospital, Melbourne, Victoria
Tom Baker Cancer Centre/Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
BC Cancer, Kelowna, British Columbia
BC Cancer - Prince George, Prince George, British Columbia
BC Cancer, Surrey, British Columbia
BC Cancer, Vancouver, British Columbia
BC Cancer, Victoria, British Columbia
London Health Sciences Centre, London, Ontario
Walker Family Cancer Centre, Saint Catharines, Ontario
St. Luke's Radiation Oncology Network, Rathgar, Dublin
Beacon Hospital, Dublin, Sandyford
Bon Secours Radiotherapy Cork in partnership with UPMC Hillman Cancer Centre, Cork, Not set
Aberdeen Royal Infirmary, Aberdeen, Scotland
Edinburgh Cancer Centre, Edinburgh, Scotland
Beatson West of Scotland Cancer Centre, Glasgow, Not set
Conditions: Metastatic Tumors
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
Recruiting
The main objective of the study is to assess efficacy and safety of dupilumab given up to 24 weeks in adults with CPUO.
This is a master protocol which includes 2 parallel-treatment, double-blind, 2- arm Phase 3 staggered studies of similar design (Study A and Study B) in male and female participants aged 18 to 90 years with CPUO. Study B design was to be adapted based on the results of Study A.
For both Study A and B, after an up-to-4-week screening period, participants with severe pruritus (... Read More
The main objective of the study is to assess efficacy and safety of dupilumab given up to 24 weeks in adults with CPUO.
This is a master protocol which includes 2 parallel-treatment, double-blind, 2- arm Phase 3 staggered studies of similar design (Study A and Study B) in male and female participants aged 18 to 90 years with CPUO. Study B design was to be adapted based on the results of Study A.
For both Study A and B, after an up-to-4-week screening period, participants with severe pruritus (worst-itch numerical rating scale \[WI-NRS ≥7) will enter a 4-week run-in period and will be treated with a non-sedative antihistamine and an emollient (moisturizer). Participants with severe pruritus (WI-NRS ≥7) at baseline will be randomized (1:1) to be treated for 24 weeks with either dupilumab or matching placebo in addition to their non-sedative antihistamine and emollient regimen. The treatment period for both study A and B will be followed by a 12-week follow-up period. Read Less
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/19/2025
Locations: Kern Allergy and Medical Research- Site Number : 8400016, Bakersfield, California +79 locations
Kern Allergy and Medical Research- Site Number : 8400016, Bakersfield, California
Allergy & Rheumatology- Site Number : 8400038, La Jolla, California
FoxHall Dermatology- Site Number : 8400042, Washington, District of Columbia
Palm Harbor Dermatology- Site Number : 8400024, Belleair, Florida
University of Miami Hospital- Site Number : 8400011, Miami, Florida
Skin Care Physicians of Georgia - Macon- Site Number : 8400030, Macon, Georgia
Aeroallergy Research Laboratory- Site Number : 8400036, Savannah, Georgia
Investigational Site Number : 3920001, Elk Grove Village, Illinois
Dawes Fretzin Clinical Research- Site Number : 8400007, Indianapolis, Indiana
Dermatology Specialists Research (DS Research) - Kentucky- Site Number : 8400031, Louisville, Kentucky
Johns Hopkins Hospital- Site Number : 8400020, Baltimore, Maryland
The Asthma and Allergy Center- Site Number : 8400014, Bellevue, Nebraska
Icahn School of Medicine at Mount Sinai- Site Number : 8400034, New York, New York
National Allergy and Asthma - North Charleston - Northside Drive- Site Number : 8400032, North Charleston, South Carolina
Complete Dermatology - Sugar Land- Site Number : 8400046, Sugar Land, Texas
Investigational Site Number : 0320005, Buenos Aires, Not set
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0320006, Buenos Aires, Not set
Investigational Site Number : 0320003, Birtinya, Queensland
Investigational Site Number : 0320007, Maroochydore, Queensland
Investigational Site Number : 1240001, Calgary, Alberta
Investigational Site Number : 1240008, Edmonton, Alberta
Investigational Site Number : 1240002, London, Ontario
Investigational Site Number : 1240003, Markham, Ontario
Investigational Site Number : 1240006, Toronto, Ontario
Investigational Site Number : 1240005, Montreal, Quebec
Investigational Site Number : 1240004, Verdun, Quebec
Investigational Site Number : 1560003, Beijing, Not set
Investigational Site Number : 1560004, Chengdu, Not set
Investigational Site Number : 1560009, Chongqing, Not set
Investigational Site Number : 1560006, Guangzhou, Not set
Investigational Site Number : 1560005, Guangzhou, Not set
Investigational Site Number : 1560002, Hangzhou, Not set
Investigational Site Number : 1560001, Shanghai, Not set
Investigational Site Number : 1560011, Suzhou, Not set
Investigational Site Number : 1560008, Wuhan, Not set
Investigational Site Number : 3800007, Varazdin, Ferrara
Universitätsklinikum Frankfurt- Site Number : 8400039, Frankfurt, Ohio
Investigational Site Number : 2760002, Berlin, Not set
Investigational Site Number : 2760003, Mainz, Not set
Investigational Site Number : 0320004, Athens, Santa Fe
Investigational Site Number : 3480001, Budapest, Not set
Investigational Site Number : 3480005, Debrecen, Not set
Investigational Site Number : 3480003, Szeged, Not set
Investigational Site Number : 3480002, Zalaegerszeg, Not set
Investigational Site Number : 3800004, Torette, Ancona
Investigational Site Number : 3800005, Florence, Firenze
Investigational Site Number : 3800003, Milan, Milano
Investigational Site Number : 3800002, Rozzano, Milano
Investigational Site Number : 3800006, Naples, Napoli
Investigational Site Number : 3800001, Rome, Roma
Ospedale Sant' Anna- Site Number : 8400037, Como, Not set
Investigational Site Number : 3920007, Urayasu-shi, Chiba
Investigational Site Number : 3920003, Obihiro, Hokkaido
Investigational Site Number : 3920006, Sapporo, Hokkaido
Investigational Site Number : 3920004, Habikino, Osaka
Investigational Site Number : 3920002, Sakai, Osaka
Investigational Site Number : 3920005, Izumo, Shimane
Investigational Site Number : 4100003, Busan, Busan-gwangyeoksi
Investigational Site Number : 4100004, Ansan-si, Gyeonggi-do
Investigational Site Number : 4100005, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100002, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100001, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 6160007, Wroclaw, Dolnoslaskie
Investigational Site Number : 6160003, Wroclaw, Dolnoslaskie
Investigational Site Number : 6160003, Wroclaw, Dolnoslaskie
Investigational Site Number : 6160001, Krakow, Malopolskie
Investigational Site Number : 6160008, Warsaw, Mazowieckie
Investigational Site Number : 6160005, Warsaw, Mazowieckie
Diabetol- Site Number : 8400047, Prešov, South Carolina
Investigational Site Number : 7240003, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240006, Barcelona, Catalunya [Cataluña]
Investigational Site Number : 7240001, Pontevedra, Pontevedra [Pontevedra]
Investigational Site Number : 7240005, Alicante, Not set
Investigational Site Number : 7240004, Córdoba, Not set
Investigational Site Number : 1580003, Kaohsiung, Not set
Investigational Site Number : 1580004, New Taipei City, Not set
Investigational Site Number : 1580001, Taipei City, Not set
Investigational Site Number : 1580002, Taoyuan City, Not set
Investigational Site Number : 0320002, Leicester, Leicestershire
Conditions: Pruritus
Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
Recruiting
The main objective of this study is to compare the efficacy of sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab in participants with chronic lymphocytic leukemia (CLL)
The main objective of this study is to compare the efficacy of sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab in participants with chronic lymphocytic leukemia (CLL) Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Alaska Oncology and Hematology, Llc, Anchorage, Alaska +206 locations
Alaska Oncology and Hematology, Llc, Anchorage, Alaska
City of Hope National Medical Center, Duarte, California
University of California San Diego (Ucsd) Moores Cancer Center, La Jolla, California
Valkyrie Clinical Trials, Los Angeles, California
UCLA Department of Medicine Hematologyoncology, Los Angeles, California
Chao Family Comprehensive Cancer Center, Orange, California
Stanford Medicine, Palo Alto, California
University of Colorado Cancer Center, Aurora, Colorado
Yale University, Yale Cancer Center, New Haven, Connecticut
Medstar Georgetown University Hospital, Washington, District of Columbia
Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida
Moffitt Cancer Center, Tampa, Florida
Southeastern Regional Medical Center, Newnan, Georgia
Northwestern University, Chicago, Illinois
Illinois Cancercare, Pc, Peoria, Illinois
Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana
University of Iowa Hospitals and Clinics, Iowa City, Iowa
Mission Cancer and Blood, Waukee, Iowa
The University of Kansas Cancer Center, Westwood, Kansas
Norton Cancer Institute Pavilion, Louisville, Kentucky
Ochsner Clinic Foundation, New Orleans, Louisiana
University of Minnesota, Minneapolis, Minnesota
Washington University School of Medicine, Saint Louis, Missouri
John Theurer Cancer Center Hackensack University Medical Center, Hackensack, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Laura and Isaac Perlmutter Cancer Center At Nyu Langone Health, New York, New York
Columbia University Medical Center, New York, New York
Clinical Research Alliance, Inc, Westbury, New York
University of North Carolina At Chapel Hill, Chapel Hill, North Carolina
Atrium Health Levine Cancer Institute (Lci), Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
Cleveland Clinic Foundation, Cleveland, Ohio
The James Cancer Hospital and Solove Research Institute At Ohio State University, Columbus, Ohio
Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene, Oregon
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Scri Tennessee Oncology Chattanooga, Chattanooga, Tennessee
Huntsman Cancer Institute, Salt Lake City, Utah
Virginia Cancer Institute, Richmond, Virginia
Vcu Health Systemmassey Comprehensive Cancer Center, Richmond, Virginia
Fred Hutchinson Cancer Research Center, Seattle, Washington
Gunderson Health System, La Crosse, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Concord Repatriation General Hospital, Concord, New South Wales
Genesiscare North Shore, St Leonards, New South Wales
Pindara Private Hospital, Benowa, Queensland
Sunshine Coast Hospital and Health Service, Birtinya, Queensland
Princess Alexandra Hospital, Woolloongabba, Queensland
Flinders Medical Centre, Bedford PK, South Australia
Monash Health, Clayton, Victoria
St Vincents Hospital Melbourne, Fitzroy, Victoria
Austin Health, Heidelberg, Victoria
Cabrini Hospital Malvern, Malvern East, Victoria
The Alfred Hospital, Melbourne, Victoria
Hollywood Private Hospital, Nedlands, Western Australia
Medizinische Universitatsklinik Innsbruck, Innsbruck, Not set
Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg, Salzburg, Not set
Hanusch Krankenhaus, Wien, Not set
Unesp Faculdade de Medicina Da Universidade Estadual Paulista Campus Botucatu, Botucatu, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre, Not set
Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp, Ribeirao Preto, Not set
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular, Sao Paulo, Not set
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, Sao Paulo, Not set
Cross Cancer Institute, Edmonton, Alberta
British Columbia Cancer Agency the Vancouver Centre, Vancouver, British Columbia
Cancercare Manitoba, Winnipeg, Manitoba
Lakeridge Health, Oshawa, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Centre Integre de Sante Et de Services Sociaux de La Monteregie Centre, Greenfield Park, Quebec
Centre Hospitalier de Luniversite de Montreal (Chum), Montreal, Quebec
Unite de Recherche Clinique Du Cisss Des Laurentides, SaintJerome, Quebec
Ciusss de Lestrie Chus, Sherbrooke, Quebec
Arthur Je Child Comprehensive Cancer Centre, Calgary, Not set
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic), Quebec, Not set
The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui
Peking University Third Hospital, Beijing, Beijing
Chongqing University Cancer Hospital, Chongqing, Chongqing
Fujian Medical University Union Hospital, Fuzhou, Fujian
Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong
Jieyang Peoples Hospital (Jieyang Affiliated Hospital, Sun Yat Sen University ), Jieyang, Guangdong
The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi
Nanyang Central Hospital, Nanyang, Henan
Henan Cancer Hospital, Zhengzhou, Henan
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei
Yichang Central Peoples Hospitaljiangnan Branch, Yichang, Hubei
The First Peoples Hospital of Changzhou, Changzhou, Jiangsu
Jiangsu Province Hospital, Nanjing, Jiangsu
Affiliated Hospital of Nantong University, Nantong, Jiangsu
The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
The First Hospital of China Medical University, Shenyang, Liaoning
The Second Affiliated Hospital of Xian Jiaotong University, Xian, Shaanxi
Shandong Provincial Hospital, Jinan, Shandong
Jining No Peoples Hospital West Branch, Jining, Shandong
Yantai Yuhuangding Hospital, Yantai, Shandong
West China Hospital, Sichuan University, Chengdu, Sichuan
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu, Sichuan
Institute of Hematology and Hospital of Blood Disease, Tianjin, Tianjin
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang
Fakultni Nemocnice Brno, Brno, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni Nemocnice Olomouc, Olomouc, Not set
Fakultni Nemocnice Ostrava, Ostrava, Not set
Fakultni Nemocnice Plzen, Plze, Not set
Vseobecna Fakultni Nemocnice V Praze, Praha, Not set
Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux, Not set
Chu Clermont Ferrand Therapie Cellulaire and Hematolo, Clermontferrand, Not set
Clinique Louis Pasteur, Esseylesnancy, Not set
Centre Hospitalier Le Mans, Le Mans, Not set
Chu Lille, Lille, Not set
Centre Leon Berard, Lyon Cedex, Not set
Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes, Not set
Hopital Prive Du Confluent, Nantes, Not set
Hopital de La Pitie Salpetriere, Paris, Not set
Chu Rennes, Rennes Cedes, Not set
Centre Henri Becquerel, Rouen Cedex, Not set
Chu Tours Hopital Bretonneau, Tours, Not set
Chu Nancy Hopital Brabois, VandoeuvrelesNancy, Not set
Praxis Am Volkspark, Berlin, Not set
Centrum Fur Haematologie Und Onkologie Bethanien, Frankfurt am Main, Not set
Universitaetsklinikum Schleswig Holstein Campus Luebeck, Luebeck, Not set
Assuta Ashdod Medical Center, Ashdod, Not set
Carmel Medical Center, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Hadassah University Hospital Ein Kerem, Jerusalem, Not set
Assuta Medical Center, Tel Aviv Jaffa, Not set
Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi, Bologna, Not set
Azienda Ospedaliero Universitaria Di Ferrara, Ferrara, Not set
Istituto Europeo Di Oncologia, Milano, Not set
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set
Aou Maggiore Della Carita, Novara, Not set
Azienda Ospedaliera Di Padova, Padova, Not set
Ospedale Santa Maria Della Misericordia, Perugia, Not set
Aichi Cancer Center Hospital Clinical Oncology, Nagoya, Aichi
Chiba Cancer Center, Chibashi, Chiba
Nho Shikoku Cancer Center, MatsuyamaShi, Ehime
Aiiku Hospital, SapporoShi, Hokkaido
Hyogo Prefectural Amagasaki General Medical Center, AmagasakiCity, Hyogo
Kagoshima University Hospital, Kagoshimashi, Kagoshima
Tokai University Hospital, Iseharashi, Kanagawa
Tohoku University Hospital, Sendaishi, Miyagi
Niigata University Medical and Dental Hospital, Niigatashi, Niigata
Kurashiki Central Hospital, Kurashikishi, Okayama
Kansai Medical University Hospital, Hirakata, Osaka
Kindai University Hospital, Osakasayama, Osaka
National Cancer Center Hospital, ChuoKu, Tokyo
Yamagata University Hospital, Yamagatashi, Yamagata
Aomori Prefectural Central Hospital, Aomori, Not set
Kumamoto University Hospital, Kumamoto, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Yokohama Municipal Citizens Hospital, YokohamaShi, Not set
Seoul National University Bundang Hospital, BundangGu SeongnamSi, Gyeonggi-do
National Cancer Center (Korea), IlsandongGu GoyangSi, Gyeonggi-do
The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi
Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Asan Medical Center, SongpaGu, Seoul Teugbyeolsi
Noordwest Ziekenhuisgroep, Alkmaar, Not set
Flevoziekenhuis, Almere, Not set
Meander Medisch Centrum, Amersfoort, Not set
Amsterdam Umc Vu Mc, Amsterdam, Not set
Reinier de Graaf Gasthuis, Delft, Not set
Albert Schweitzer Ziekenhuis, Dordrecht, Not set
Martini Ziekenhuis, Groningen, Not set
Maasstad Hospital, Rotterdam, Not set
Ikazia Ziekenhuis, Rotterdam, Not set
Franciscus Gasthuis and Vlietland, Schiedam, Not set
Hagaziekenhuis, Sgravenhage, Not set
Elisabeth Tweesteden Ziekenhuis, Tilburg, Not set
North Shore Hospital, Auckland, Not set
Auckland City Hospital, Auckland, Not set
Health New Zealand Canterbury, Christchurch, Not set
Dunedin Hospital, Dunedin, Not set
Tauranga Hospital, Tauranga, Not set
Wellington Regional Hospital (Ccdhb), Wellington, Not set
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz, Not set
Uniwersytecki Szpital Kliniczny Nr W Lublinie, Lublin, Not set
Uniwersytecki Szpital Kliniczny, Poznan, Not set
Centralny Szpital Kliniczny Uck Wum, Warszawa, Not set
Instytut Hematologii I Transfuzjologii, Warszawa, Not set
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu, Wroclaw, Not set
Auxilio Mutuo Cancer Center, San Juan, Not set
Hospital Universitario de Burgos, Burgos, Not set
Institut Catala Doncologia Hospital Duran I Reynals, Hospitalet de LLobregat, Not set
Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Not set
Md Anderson Cancer Center Madrid Spain, Madrid, Not set
Hospital Universitario de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Ramon Y Cajal, Madrid, Not set
Hospital La Candelaria, Tenerife, Not set
Karolinska Universitetssjukhuset Solna, Stockholm, Not set
Ankara University Medical Faculty, Ankara, Not set
Gazi University, Ankara, Not set
Erciyes University School of Medicine, Kayseri, Not set
Kocaeli Universitesi Tip Fakultesi, Kocaeli, Not set
University Hospitals Dorset Royal Bournemouth Hospital, Bournemouth, Not set
Kent and Canterbury Hospital, Canterbury, Not set
Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set
St Jamess University Hospital, Leeds, Not set
The Clatterbridge Cancer Centre Liverpool, Liverpool, Not set
University College Hospital, London, Not set
Kings College, London, Not set
Norfolk and Norwich University Hospitals Nhs Foundation Trust, Norwich, Not set
Southampton General Hospital, Southampton, Not set
Royal Marsden Nhs Foundation Royal Marsden Hospital, Sutton, Not set
Conditions: CLL
Microvascular Monitoring in Circulatory Shock and Sepsis (MiMICSS)
Recruiting
Investigation of the feasibility of using near-infrared spectroscopy (NIRS) to monitor microvascular function in critically ill patients.
Investigation of the feasibility of using near-infrared spectroscopy (NIRS) to monitor microvascular function in critically ill patients. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Health Sciences Centre Winnipeg, Winnipeg, Manitoba
Health Sciences Centre Winnipeg, Winnipeg, Manitoba
Conditions: Sepsis, Shock, Critical Illness
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
Recruiting
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma.
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Local Institution - 0071, Birmingham, Alabama +123 locations
Local Institution - 0071, Birmingham, Alabama
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California
Local Institution - 0130, Miami, Florida
Winship Cancer Institute, Emory University, Atlanta, Georgia
Local Institution - 0218, Shreveport, Louisiana
Local Institution - 0196, Boston, Massachusetts
Local Institution - 0067, Charlotte, North Carolina
Local Institution - 0216, Winston-Salem, North Carolina
Local Institution - 0193, Cleveland, Ohio
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Local Institution - 0044, Salt Lake City, Utah
Local Institution - 0195, Milwaukee, Wisconsin
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0214, ABB, Ciudad Autónoma De Buenos Aires
Hospital Aleman, Buenos Aires, Ciudad Autónoma De Buenos Aires
Royal Prince Alfred Hospital, Camperdown, New South Wales
Local Institution - 0190, Liverpool, New South Wales
Local Institution - 0140, Brisbane, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Monash Health, Clayton, Victoria
Peter MacCallum Cancer Centre, Melbourne, Victoria
Local Institution - 0191, Melbourne, Victoria
Fiona Stanley Hospital, Murdoch, Western Australia
Ordensklinikum Linz GmbH Elisabethinen, Linz, Oberösterreich
Hanusch-Krankenhaus, Vienna, Not set
Local Institution - 0220, Edegem, Antwerpen
Local Institution - 0217, Brussels, Bruxelles-Capitale, Région De
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir, Namur
UZ Gent, Gent, Oost-Vlaanderen
Local Institution - 0012, Nova Lima, Minas Gerais
Local Institution - 0103, São Paulo, SAO Paulo
Local Institution - 0013, Sao Paulo, São Paulo
Local Institution - 0031, São Paulo, Not set
Local Institution - 0069, Calgary, Alberta
Vancouver General Hospital, Vancouver, British Columbia
QEII Health Sciences Centre - Victoria General Site, Halifax, Nova Scotia
Local Institution - 0192, Hamilton, Ontario
CIUSSS de l'Est-de-l'Île-de-Montréal, Montreal, Quebec
Fakultní nemocnice Brno Bohunice, Brno, Brno-město
Local Institution - 0093, Hradec Kralove, Hradec Králové
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Rigshospitalet, Copenhagen, Hovedstaden
Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland
Local Institution - 0208, Roskilde, Sjælland
Odense Universitetshospital, Odense, Syddanmark
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki, Uusimaa
Hopital Claude Huriez - CHU de Lille, Lille, Nord
Local Institution - 0194, Nantes, Pays-de-la-Loire
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Henri Mondor Hospital, Creteil, Val-de-Marne
Local Institution - 0210, Paris, Not set
TUM Universitätsklinikum, Technische Universität München, Munich, Bayern
Medizinische Hochschule Hannover, Hannover, Niedersachsen
Local Institution - 0211, Magdeburg, Sachsen-Anhalt
Local Institution - 0204, Chemnitz, Sachsen
Universitätsklinikum Leipzig, Leipzig, Sachsen
Local Institution - 0212, Kiel, Schleswig-Holstein
Local Institution - 0213, Berlin, Not set
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Klinikum Nuernberg Nord, Nuremberg, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
University Hospital of Patras, Patras, Achaḯa
Evangelismos General Hospital of Athens, Athens, Attikí
Local Institution - 0115, Chaidari, Attikí
Local Institution - 0125, Budapest, Not set
Sheba Medical Center, Ramat Gan, HaMerkaz
Sourasky Medical Center, Tel Aviv, Tell Abīb
Hadassah Medical Center, Jerusalem, Yerushalayim
Local Institution - 0107, Milan, Lombardia
Istituto Clinico Humanitas, Rozzano, Milano
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Piemonte
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Local Institution - 0119, Genova, Not set
Local Institution - 0106, Udine, Not set
Nagoya City University Hospital, Nagoya, Aichi
Local Institution - 0105, Kashiwa, Chiba
Hyogo Medical University Hospital, Nishinomiya, Hyogo
Kanazawa University Hospital, Kanazawa, Ishikawa
Kyushu University Hospital, Fukuoka, Not set
Kumamoto University Hospital, Kumamoto, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Red Cross Hospital, Osaka, Not set
Japanese Red Cross Medical Center, Tokyo, Not set
Yamagata University Hospital, Yamagata, Not set
Local Institution - 0147, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0146, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0148, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0149, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0176, Nijmegen, Gelderland
Maastricht UMC+, Maastricht, Limburg
Local Institution - 0179, Amsterdam, Noord-Holland
Universitair Medisch Centrum Utrecht, Utrecht, Not set
Oslo Universitetssykehus Ullevål, Oslo, Not set
Centrum Onkologii Ziemi Lubelskiej, Lublin, Lubelskie
Uniwersyteckie Centrum Kliniczne, Gdańsk, Pomorskie
Local Institution - 0084, Katowice, Not set
Local Institution - 0183, Łódź, Łódzkie
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Fundeni Clinical Institute, Bucuresti, București
Institutul Regional de Oncologie, Iași, Not set
Local Institution - 0178, Riyadh, Not set
Local Institution - 0180, Singapore, Central Singapore
Local Institution - 0181, Singapore, Central Singapore
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña]
Local Institution - 0203, Palma, Balears [Baleares]
Local Institution - 0201, Badalona, Barcelona [Barcelona]
Clinica Universidad de Navarra, Pamplona, Navarra
Local Institution - 0202, Granada, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Local Institution - 0023, Lund, Skåne Län [se-12]
Karolinska Universitetssjukhuset Huddinge, Huddinge, Not set
Inselspital Bern, Bern, Berne
Cantonal Hospital St.Gallen, st.Gallen, Sankt Gallen
Local Institution - 0150, Taipei City, Taipei
Local Institution - 0151, Taichung, Not set
Local Institution - 0152, Taipei, Not set
Local Institution - 0200, Taipei, Not set
Local Institution - 0170, Ankara, Not set
Addenbrooke's Hospital, Cambridge, Cambridgeshire
Local Institution - 0155, London, London, City Of
Local Institution - 0157, Oxford, Oxfordshire
The Christie NHS Foundation Trust, Manchester, Not set
Freeman Hospital, Newcastle upon Tyne, Not set
Conditions: Relapsed or Refractory Multiple Myeloma (RRMM)
A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
Recruiting
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessme... Read More
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessments, leukapheresis and the Pretreatment evaluation;
* Treatment, which starts with the administration of lymphodepleting (LD) chemotherapy and continues through JCAR017 administration at Day 1 with follow-up through Day 29;
* Posttreatment, which includes follow-up assessments for disease status and safety for 5 years. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: UCLA Medical Centre-Santa Monica, Santa Monica, California +58 locations
UCLA Medical Centre-Santa Monica, Santa Monica, California
University Of Colorado Cancer Center, Aurora, Colorado
Yale Cancer Center, New Haven, Connecticut
Local Institution - 0601, Hollywood, Florida
Washington University School Of Medicine, Miami, Florida
Northwestern University, Chicago, Illinois
Local Institution - 109, Niles, Illinois
University Of Iowa, Iowa City, Iowa
Cancer Center of Kansas, Wichita, Kansas
University of Maryland - Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Massachusetts General Hospital - Dana-Farber Cancer Institute, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Karmanos Cancer Center, Detroit, Michigan
Local Institution - 118, Detroit, Michigan
Atlantic Health System Morristown Medical Center, Morristown, New Jersey
Memorial Sloan Kettering Cancer Center, New York, New York
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Local Institution - 120, Fargo, North Dakota
Cleveland Clinic Foundation, Cleveland, Ohio
Providence Cancer Center/Earle A. Chiles Res. Inst., Portland, Oregon
University of Pennsylvania - Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania
Local Institution - 126, Pittsburgh, Pennsylvania
Local Institution - 113, Sioux Falls, South Dakota
Local Institution - 125, Knoxville, Tennessee
Texas Oncology, Dallas, Texas
Houston Methodist Hospital, Houston, Texas
The University of Texas - MD Anderson Cancer Center, Houston, Texas
University Of Virginia Health System, Charlottesville, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
Allgemeinen Krankenhaus (AKH) Wien - Medizinische Universitaet Wien, Wien, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
Hopital Maisonneuve - Rosemont, Montreal, Quebec
CHRU-Hopital Claude Huriez, Lille, Not set
CHU Montpellier - Hôpital Saint Eloi, Montpellier CEDEX 5, Not set
Hopital Saint Louis, Paris Cedex 10, Not set
Centre Hospitalier Lyon-Sud, Pierre-Benite CEDEX, Not set
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes Cedex 02, Not set
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse, Not set
Universitaetsklinikum Ulm, Ulm, Baden-Wurttemberg
Universitätsklinikum Regensburg, Regensburg, Bayern
Local Institution - 506, Berlin, Not set
Local Institution - 503, Karlsruhe, Not set
Local Institution - 505, Kiel, Not set
University Hospital Cologne, Köln, Not set
LMU Klinikum der Universitat Munchen, Munich, Not set
Azienda Ospedaliera Papa Giovanni Xxiii, Bergamo, Not set
Local Institution - 302, Bologna, Not set
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale, Naples, Not set
Local Institution - 553, Sapporo-shi, Hokkaido
Local Institution - 550, Chuo-ku, Tokyo
Local Institution - 551, Minato-ku, Tokyo
Local Institution - 552, Fukuoka, Not set
Local Institution - 352, Barcelona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Virgen Del Rocio, Sevilla, Not set
Karolinska Hospital, Stockholm, Not set
University College London Hospitals NHS Foundation Trust - University College Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Conditions: Lymphoma, Non-Hodgkin
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
Recruiting
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients... Read More
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT. Read Less
Gender:
ALL
Ages:
Between 3 years and 29 years
Trial Updated:
08/19/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +162 locations
Children's Hospital of Alabama, Birmingham, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
GenesisCare USA - Las Vegas, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Cancer Care Specialists - Reno, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Albany Medical Center, Albany, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Maimonides Medical Center, Brooklyn, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Healthcare, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Christchurch Hospital, Christchurch, Not set
Conditions: Central Nervous System Nongerminomatous Germ Cell Tumor, Embryonal Carcinoma, Immature Teratoma, Malignant Teratoma, Mixed Germ Cell Tumor, Pineal Region Germ Cell Tumor, Pineal Region Immature Teratoma, Pineal Region Yolk Sac Tumor, Choriocarcinoma, Suprasellar Germ Cell Tumor
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Recruiting
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Chao Family Comprehensive Cancer Center, Orange, California +175 locations
Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute, Palo Alto, California
Scripps Prebys Cancer Center, San Diego, California
Rocky Mountain Cancer Centers (Williams) Usor, Aurora, Colorado
Yale University, Yale Cancer Center, New Haven, Connecticut
Eastern Connecticut Hematology and Oncology, Norwich, Connecticut
Cleveland Clinic Florida, Weston, Florida
Northwestern University, Chicago, Illinois
Illinois Cancer Specialists (Niles) Usor, Niles, Illinois
Mission Cancer and Blood, Waukee, Iowa
University of Louisville, Brown Cancer Center, Louisville, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Dana Farber Cancer Institute, Boston, Massachusetts
The Cancer and Hematology Centers, Grand Rapids, Michigan
Mayo Clinic Rochester, Rochester, Minnesota
Memorial Sloan Kettering Cancer Center Mskcc, New York, New York
Clinical Research Alliance, Inc, Westbury, New York
University of North Carolina At Chapel Hill, Chapel Hill, North Carolina
Levine Cancer Center, Charlotte, North Carolina
Oncology Hematology Care Clinical Trials, Llc, Cincinnati, Ohio
Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene, Oregon
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
Upmc Hillman Cancer Center(Univ of Pittsburgh), Pittsburgh, Pennsylvania
Tennessee Oncology, Nashville, Tennessee
Texas Oncology Baylorcharles A Sammons Cancer Center, Dallas, Texas
Ut Southwestern Medical Center, Dallas, Texas
Texas Oncology San Antonio Medical Center Usor, San Antonio, Texas
Texas Oncology Tyler, Tyler, Texas
Northwest Cancer Specialist, Pc(Us Oncology Research), Vancouver, Washington
Hospital Aleman, Caba, Not set
FUNDALEU, Caba, Not set
Instituto Alexander Fleming (Iaf), Ciudad Autonoma Buenos Aires, Not set
Blacktown Cancer and Haematology Centre, Blacktown, New South Wales
St George Hospital, Kogarah, New South Wales
Northern Nsw Health District, Lismore, New South Wales
Macquarie University, North Ryde, New South Wales
Genesiscare North Shore, St Leonards, New South Wales
Wollongong Private Hospital, Wollongong, New South Wales
Sunshine Coast Hospital and Health Service, Birtinya, Queensland
Princess Alexandra Hospital, Woolloongabba, Queensland
Monash Health, Clayton, Victoria
St Vincents Hospital Melbourne, Fitzroy, Victoria
Peter Maccallum Cancer Centre, Melbourne, Victoria
The Alfred Hospital, Melbourne, Victoria
Rockingham Hospital, Cooloongup, Western Australia
Perth Blood Institute, West Perth, Western Australia
Medizinische Universitatsklinik Innsbruck, Innsbruck, Not set
Medical University Vienna Oncology, Wien, Not set
Hanusch Krankenhaus, Wien, Not set
Cliniques Universitaires Saint Luc, Brussels, Not set
Uz Antwerpen, Edegem, Not set
University Hospitals Leuven, Leuven, Not set
CETUS, Belo Horizonte, Not set
Universidade de Campinas Centro de Hematologia E Hemoterapia, Campinas, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Complexo Hospitalar de Niteroi, Niteroi, Not set
Irmandade Da Santa Casa de Misericordia Hospital Porto Alegre, Porto Alegre, Not set
Hospital Sao Lucas, Rio de Janeiro, Not set
Instituto Dor de Pesquisa E Ensino Rio de Janeiro, Rio de Janeiro, Not set
Hospital Santa Izabel, Salvador, Not set
Hospital Samaritano Sao Paulo, Sao Paulo, Not set
Hospital Nove de Julho Dasa, Sao Paulo, Not set
Instituto Brasileiro de Controle Do Cancer, Sao Paulo, Not set
Instituto Dor de Pesquisa E Ensino Sao Paulo, Sao Paulo, Not set
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular, Sao Paulo, Not set
Hospital Santa Rita de Cassia Afecc, Vitoria, Not set
Cross Cancer Institute, Edmonton, Alberta
British Columbia Cancer Agency the Vancouver Centre, Vancouver, British Columbia
Cancercare Manitoba, Winnipeg, Manitoba
Newfoundland and Labrador Health Services, St Johns, Newfoundland and Labrador
The Ottawa Hospital, Ottawa, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Ciusss Nim Hscm, Montreal, Quebec
Arthur Je Child Comprehensive Cancer Centre, Calgary, Not set
China Japan Friendship Hospital, Beijing, Beijing
Fujian Provincial Hospital, Fuzhou, Fujian
Fujian Medical University Union Hospitalqishan Branch, Fuzhou, Fujian
The First Affiliated Hospital of Xiamen University, Xiamen, Fujian
Guangzhou First Peoples Hospital, Guangzhou, Guangdong
Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong
Guangxi Medical University Cancer Hospital Wuxiang Branch, Nanning, Guangxi
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia
Zhongda Hospital Southeast University, Nanjing, Jiangsu
Suzhou Municipal Hospitalbaita Branch, Suzhou, Jiangsu
Affiliated Hospital of Jiangnan University South Campus, Wuxi, Jiangsu
Northern Jiangsu Peoples Hospital, Yangzhou, Jiangsu
Jiangxi Cancer Hospital, Nanchang, Jiangxi
Liaoning Cancer Hospital and Institute, Shenyang, Liaoning
Shaanxi Provincial Peoples Hospital, Xian, Shaanxi
Shandong Provincial Hospital, Jinan, Shandong
Jining No Peoples Hospital West Branch, Jining, Shandong
The Affiliated Hospital of Qingdao University Branch West Coast, Qingdao, Shandong
Affiliated Zhongshan Hospital of Fudan University, Shanghai, Shanghai
West China Hospital, Sichuan University, Chengdu, Sichuan
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch, Tianjin, Tianjin
The Affiliated Peoples Hospital of Ningbo University, Ningbo, Zhejiang
Taizhou Hospital of Zhejiang Province (East), Taizhou, Zhejiang
Fakultni Nemocnice Brno, Brno, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Vseobecna Fakultni Nemocnice V Praze, Praha, Not set
Ustav Hematologie A Krevni Transfuze (Uhkt), Praha, Not set
University Hospital of Aalborg, Denmark, Aalborg, Not set
Rigshospitalet, Copenhagen, Not set
Odense University Hospital, Odense C, Not set
Zealand University Hospital, Roskilde, Roskilde, Not set
Chu Clermont Ferrand Therapie Cellulaire and Hematolo, Clermontferrand, Not set
Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes, Not set
Hopital de La Pitie Salpetriere, Paris, Not set
Chu Hopital Lyon Sud, PierreBenite, Not set
Hopital Robert Debre, Reims, Not set
Chu Rennes, Rennes Cedes, Not set
Centre Henri Becquerel, Rouen Cedex, Not set
Icans Institut de Cancerologie Strasbourg Europe, Strasbourg, Not set
Iuct Oncopole, Toulouse, Not set
Chu Nancy Hopital Brabois, VandoeuvrelesNancy, Not set
Osp Kurfuerstendamm, Berlin, Not set
Gokos Gmbh, Dresden, Not set
Universitatsklinikum Jena Klinik Fur Innere Medizin Ii, Jena, Not set
Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Not set
Uniklinik Koeln (Aoer), Koln, Not set
Klinikum Der Universitat Munchen Medizinische Klinik Und Poliklinik Iii, Munchen, Not set
Stauferklinikum Schwabisch Gmund Kliniken Ostalb, Mutlangen, Not set
Dietrich Bonhoeffer Klinikum Neubrandenburg, Neubrandenburg, Not set
Medizinische Universitaetsklinik, Tubingen, Not set
Universitaetsklinikum Ulm, Ulm, Not set
Haematologisch Onkologische Schwerpunktpraxis, Wurzburg, Not set
Mater Misericordiae University Hospital, Dublin, Not set
St Jamess Hospital, Dublin, Not set
University Hospital Galway, Galway, Not set
University Hospital Limerick, Limerick, Not set
Azienda Ospedaliera Policlinico Di Bari, Bari, Not set
Ao Brotzu Ospedale Oncologico Armando Businco, Cagliari, Not set
Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Catania, Not set
Azienda Ospedaliero Universitaria Di Ferrara, Ferrara, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set
Universita Degli Studi Di Modena Azienda Ospedaliere Policlinco, Modena, Not set
Asl Salerno Andrea Tortora, Pagani, Not set
Pusan National University Hospital, SeoGu, Busan Gwang'yeogsi
Seoul National University Bundang Hospital, BundangGu SeongnamSi, Gyeonggi-do
National Cancer Center (Korea), IlsandongGu GoyangSi, Gyeonggi-do
Samsung Medical Center, GangnamGu, Seoul Teugbyeolsi
The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi
Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Flevoziekenhuis, Almere, Not set
Rijnstate, Arnhem, Not set
Albert Schweitzer Ziekenhuis, Dordrecht, Not set
Tergooi Mc, Hilversum, Not set
North Shore Hospital, Auckland, Not set
Auckland City Hospital, Auckland, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz, Not set
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu, Torun, Not set
Centralny Szpital Kliniczny Uck Wum, Warszawa, Not set
Uniwersytecki Szpital Kliniczny Hematology, Wroclaw, Not set
Vall D Hebron Institute of Oncology Vhio, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Ico Lhospitalet Hospital Duran I Reynals, Lhospitalet de Llobregat, Not set
Hospital de La Princesa, Madrid, Not set
Hospital Universitario Infanta Leonor, Madrid, Not set
Costa Del Sol (Marbella, Malaga), Marbella, Not set
Hospital Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Hospital Virgen de Valme (Sevilla), Sevilla, Not set
Sahlgrenska University Hospital Hematology, Goteborg, Not set
Skanes Universitetssjukhus I Lund, Lund, Not set
Karolinska Universitetssjukhuset Solna, Stockholm, Not set
Uppsala Akademiska Sjukhus, Uppsala, Not set
University Hospitals Dorset Royal Bournemouth Hospital, Bournemouth, Not set
Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set
St Jamess University Hospital, Leeds, Not set
Kings College Hospital, London, Not set
Freeman Hospital, NewCastle Upon Tyne, Not set
Clatterbridge Cancer Centre, Wirral, Not set
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
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