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All Clinical Trials in Canada
A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1189 - 1200 of 3904
Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine
Recruiting
Revision total knee arthroplasty (rTKA) is a frequently performed procedure. Adequate pain management is an important feature, especially for fast-track and Enhanced Recovery After Surgery (ERAS) programs. The multimodal approach, including single shot or continuous nerve blocks with catheters and spinal or epidural morphine, is a stablished strategy. Although the administration of intrathecal morphine (IM) has been shown to significantly reduce pain scores, it is not free of adverse effects. Po... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/25/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Arthroplasties, Knee Replacement, Nerve Block, Urinary Retention Postoperative, Anesthesia, Spinal
Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: A Prospective, Multicenter, Single-Arm Observational Study
Recruiting
This study evaluates whether isolated tumor cells in the first lymph nodes near the tumor can tell researchers something important about the future of patients with a certain type of endometrial (uterine) cancer.
Gender:
ALL
Ages:
All
Trial Updated:
06/25/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota +19 locations
Conditions: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma, Stage IA1 Endometrial Cancer FIGO 2023, Stage IA2 Endometrial Cancer FIGO 2023
The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)
Recruiting
There are no therapeutic agents that have been shown to improve outcomes from severe traumatic brain injury (TBI). Critical barriers to progress in developing treatments for severe TBI are the lack of: 1) monitoring biomarkers for assessing individual patient response to treatment; 2) predictive biomarkers for identifying patients likely to benefit from a promising intervention. Currently, clinical examination remains the fundamental tool for monitoring severe TBI patients and for subject select... Read More
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
06/25/2025
Locations: UCSD Medical Center - Hillcrest Hospital, San Diego, California +10 locations
Conditions: Traumatic Brain Injury
Safety, Pharmacokinetics, and Efficacy of AT 1501 in Patients Undergoing Kidney Transplant
Recruiting
This study will evaluate the safety, PK, and efficacy of AT 1501 in patients undergoing kidney transplantation.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/25/2025
Locations: University of Cincinnati, Cincinnati, Ohio +8 locations
Conditions: Prevention of Rejection in Kidney Transplant
Distal Radius Interventions for Fracture Treatment
Recruiting
This protocol describes a multicenter, prospective randomized superiority trial comparing functional outcomes between children treated with sedated reduction versus no formal reduction.
Gender:
ALL
Ages:
Between 4 years and 10 years
Trial Updated:
06/25/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +25 locations
Conditions: Fracture Distal Radius
Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder
Recruiting
A Phase 2, open-label, multicenter study to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), and safety of inebilizumab in eligible pediatric participants 2 to \< 18 years of age with recently active neuromyelitis optica spectrum disorder (NMOSD) who are seropositive for autoantibodies against aquaporin-4 (AQP4-immunoglobulin \[Ig\]G).
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
06/25/2025
Locations: UCSD Altman Clinical and Translational Research Institute Building, La Jolla, California +17 locations
Conditions: Neuromyelitis Optica Spectrum Disorder
Type 1 Diabetes, Exercise and Mentoring Trial
Recruiting
The proposed study aims to improve the psychosocial health of adolescents living with type 1 diabetes (T1D). The study will generate knowledge and support knowledge mobilization about the effectiveness of a novel model of care for psychosocial health and self-management for adolescents living with type 1 diabetes (T1D). The novel model of care is the recruitment and training if young adult mentors to deliver a behavioural intervention that empowers adolescents with T1D to increase daily physical... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
06/25/2025
Locations: the Children's Hospital Research Institute of Manitoba and the University of Manitoba, Winnipeg, Manitoba +1 locations
Conditions: Type 1 Diabetes, Physical Activity
Low Concentration Local Anesthesia Fascia Iliaca Block for Total Hip Arthroplasty
Recruiting
Fascia iliaca compartment block (FICB) is a documented option for postoperative analgesia for total hip arthroplasty (THA) surgery. FICB is demonstrated to be effective in terms of analgesia and opioid requirements decrease, however it causes quadriceps motor weakness. Current available motor sparing techniques are not as effective as FICB for analgesia. Low concentration local anesthetics (LCLA) are used with excellent results for pain control with no or minimum motor block effect, in other sce... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/25/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Arthroplasty, Replacement, Hip
Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
Recruiting
This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-cell lung cancer
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/25/2025
Locations: City of Hope, Duarte, California +63 locations
Conditions: Metastatic Non Small Cell Lung Cancer
A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors
Recruiting
This purpose of this study is to determine if experimental treatment with BMS-986488, alone, or in combinations is safe, tolerable, and has anti-cancer activity in patients with advanced malignant tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2025
Locations: John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey +7 locations
Conditions: Advanced Malignant Tumors
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
Recruiting
This is a prospective study for the long-term follow-up (LTFU) of safety and efficacy for all pediatric and adult participants exposed to Gene-modified (GM) T-cell therapy participating in a previous Celgene sponsored or Celgene alliance partner sponsored study.
Participants who received at least one infusion of GM T cells will be asked to enroll in this LTFU protocol upon either premature discontinuation from, or completion of the prior parent treatment protocol.
Gender:
ALL
Ages:
All
Trial Updated:
06/24/2025
Locations: University of Alabama Birmingham, Birmingham, Alabama +181 locations
Conditions: Neoplasms
Confirming the Effectiveness of Online Guided Self-Help Family-Based Treatment for Adolescent Anorexia Nervosa
Recruiting
With an incidence rate of about 1%, Anorexia Nervosa (AN) is a serious mental disorder associated with high mortality, morbidity, and cost. AN in youth is more responsive to early treatment but becomes highly resistant once it has taken an enduring course. The first-line treatment for adolescents with AN is Family Based Treatment (FBT). While FBT can be delivered using videoconferencing (FBT-V), therapists' limited availability hampers scalability. Guided self-help (GSH) versions of efficacious... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
06/24/2025
Locations: Stanford University, Stanford, California +1 locations
Conditions: Anorexia Nervosa
1189 - 1200 of 3904
