All Clinical Trials in Canada

A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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LANDscape MApping of Epitopes and T Cell Receptors for Selected Cancers

NCT04665388

Recruiting

This is a correlative research project aimed at characterizing the T cell mediated immune responses to hepatocellular carcinoma (HCC), as well as Epstein-Barr virus (EBV)- and human papillomavirus (HPV)-related cancers. This study will enroll approximately 105 patients over 48 months. Of these 105 patients, 30 are EBV-related cancer, 45 are HPV-related cancer, and 30 are HCC. Patients will have blood samples collected one time to identify cancer specific T cells and T cell receptors in their blo... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/27/2025

Locations: Princess Margaret Cancer Centre, Toronto, Ontario

Conditions: Solid Tumor

Learn More ›

Study of TBI-2001(Autologous CD19 Specific Chimeric Antigen Receptor (CAR) Gene-transduced T Lymphocytes) for Relapsed or Refractory CD19+ B-cell Lymphoma, CLL/SLL

NCT05963217

Recruiting

This is a Phase 1/1b, open-label, dose-escalation study to evaluate the safety and the efficacy of anti-CD19 chimeric antigen receptor (CAR) (TBI-2001) for relapsed or refractory CD19+ B-cell lymphoma Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/27/2025

Locations: Princess Margaret Cancer Centre, Toronto, Ontario

Conditions: Relapsed or Refractory CD19+ B-cell Lymphoma, Relapsed or Refractory Chronic Lymphocytic Leukemia, Relapsed or Refractory Small Lymphocytic Lymphoma

Learn More ›

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

NCT05667142

Recruiting

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of XEN1101 administered as adjunctive treatment in primary generalized tonic-clonic seizures (PGTCS).

Gender:

ALL

Ages:

12 years and above

Trial Updated:

06/27/2025

Locations: University of Alabama - Strada Patient Care Center, Neurology, Mobile, Alabama +130 locations

University of Alabama - Strada Patient Care Center, Neurology, Mobile, Alabama

Xenoscience, Phoenix, Arizona

University of Arizona - Health Science Center, Tucson, Arizona

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Brain Science Research Institute, Los Angeles, California

University of California, Irvine - Health Neurology Services, Orange, California

University California, Davis Clinical & Translation Science Center Clinical Research (CCRC), Sacramento, California

University of Colorado Anschutz Medical Campus, Aurora, Colorado

Serenity Research Center, LLC, Miami, Florida

Research Institute of Orlando, LLC, Orlando, Florida

Panhandle Research and Medical Clinic, Pensacola, Florida

Medsol Clinical Research Center Harbor Professional Centre, Port Charlotte, Florida

University of South Florida, Tampa, Florida

Encore Medical Research of Weston, LLC, Weston, Florida

Emory Brain Health Center, Atlanta, Georgia

Children's Healthcare of Atlanta, Atlanta, Georgia

Georgia Neurology & Sleep Medicine Associates, Suwanee, Georgia

Hawaii Pacific Neuroscience, Comprehensive Epilepsy Center, Honolulu, Hawaii

Consultants in Epilepsy and Neurology, PLLC, Boise, Idaho

Southern Illinois University School of Medicine, Springfield, Illinois

Indiana University School of Medicine, Indianapolis, Indiana

University of Kansas Medical Center, Kansas City, Kansas

Bluegrass Epilepsy Research, LLC, Lexington, Kentucky

University of Kentucky Albert B. Chandler Hospital (UK Healthcare), Lexington, Kentucky

University of Maryland Medical Center, Baltimore, Maryland

MedStar Franklin Square Medical Center, Baltimore, Maryland

Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland

Medstar Georgetown University Hospital, Clinton, Maryland

Brigham and Women's Hospital, Chestnut Hill, Massachusetts

UMass Memorial Medical Center, Worcester, Massachusetts

University of Michigan Hospitals, Ann Arbor, Michigan

Wayne State University, Detroit, Michigan

Michigan State University Department of Neurology, East Lansing, Michigan

Spectrum Health, Grand Rapids, Michigan

Northeast Regional Epilepsy Group, Hackensack, New Jersey

Dent Neurosciences Research Facility, Amherst, New York

SUNY Upstate Medical University, Syracuse, New York

Five Towns Neurology, Woodmere, New York

Onsite Clinical Solutions, LLC, Charlotte, North Carolina

Wake Forest Baptist Health, Winston-Salem, North Carolina

Summa Health Clinical Research Center, Akron, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

The Ohio State University, Columbus, Ohio

OhioHealth Riverside Methodist Hospital, Columbus, Ohio

University of Pennsylvania, Philadelphia, Pennsylvania

Temple University Hospital, Philadelphia, Pennsylvania

Medical University of South Carolina (MUSC), Charleston, South Carolina

ANESC Research, El Paso, Texas

UTHealth Science Center at Houston, Houston, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

University of Utah Clinical Neurosciences Center, Salt Lake City, Utah

Sentara Neurology Specialists, Virginia Beach, Virginia

University of Washington, Regional Epilepsy Center at Harborview Medical Center, Seattle, Washington

Advocate Aurora Research institute, St. Luke's Medical Center, Milwaukee, Wisconsin

Hospital General de Agudos J.M. Ramos Mejia, Buenos Aires, Not set

STAT Research S.A., Buenos Aires, Not set

Hospital Italiano, Buenos Aires, Not set

Sanatorio del Sur S.A, San Miguel De Tucumán, Not set

Southern Neurology, Kogarah, New South Wales

Mater Misericordiae Ltd, South Brisbane, Queensland

Austin Health Pharmacy Clinical Trials, Heidelberg, Victoria

The Alfred Hospital, Melbourne, Victoria

St Vincent's Hospital Melbourne, Clinical Neurosciences, Melbourne, Victoria

The Royal Melbourne Hospital, Parkville, Not set

University Hospital Innsbruck, Innsbruck, Not set

Universitaetsklinik fuer Kinder, Linz, Not set

Universitätsklinik für Neurologie, Salzburg, Not set

Universitätsklinik für Neurologie, Medizinische Universität Wien, Vienna, Not set

Cliniques Universitaires Saint-Luc, Brussel, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Multiprofile hospital for active treatment Puls AD, Blagoevgrad, Not set

MHATNP 'Sveti Naum' EAD, Sofia, Not set

First University Multiprofile Hospital for Active Treatment Sofia Sv. Joan Krastitel, Sofia, Not set

Center for Neurologic Research, Lethbridge, Alberta

Children and Women's Health Centre of BC (BC Children's Hospital), Vancouver, British Columbia

London Health Sciences Center, London, Ontario

Le Centre Hospitalier de l'Universite' de Montreal (CHUM), Montréal, Quebec

Clinical Hospital Center Osijek, Osijek, Not set

Clinical Hospital Center Rijeka, Rijeka, Not set

University Hospital Center Zagreb, Zagreb, Not set

Fakultni nemocnice v Motole Neurologicka klinika 2. LF UK a FN Motol, Prague, Not set

CHU de Lille, Hôpital Roger Salengro - Neurophysiologie clinique, Lille, Not set

Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, Not set

Hôpital Fondation A. de Rothschild, Paris, Not set

CHU de Rennes - Hôpital Pontchaillou, Rennes, Not set

CHU de Strasbourg - Hôpital de Hautepierre, Strasbourg, Not set

Universitätsklinikum Aachen, Aachen, Not set

Vivantes Humboldt Klinikum, Berlin, Not set

Bethel Epilepsy Centre, Bielefeld, Not set

Universitätsklinikum Frankfurt, Frankfurt, Not set

Philipps-Universität Marburg, Marburg, Not set

Klinikum der Universität München, München, Not set

Epilepsiezentrum Kleinwachau gemeinnützige GmbH, Radeberg, Not set

Universitätsklinikum Tübingen, Tuebingen, Not set

Universitätsklinikum Ulm, Ulm, Not set

Hadassah University Medical Center, Jerusalem, Not set

The Chaim Sheba Medical Center, Ramat Gan, Not set

Kaplan Medical Center, Reẖovot, Not set

The Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona, Ancona, Not set

Università Degli Studi Gabriele d'Annunzio Di Chieti, Chieti, Not set

Azienda Ospedaliero Universitaria Pisana, Pisa, Not set

Ospedalo Pediatrico Bambino Gesu, Roma, Not set

Policlinico Umberto I, Roma, Not set

Grupo Medico Camino SC, Ciudad de México, Not set

Human Science Research Trials S. de R.L. de C.V., Mexico City, Not set

Neurociencias Estudios Clínicos S.C, Sinaloa, Not set

Kempenhaeghe, Heeze, Not set

Centrum Medyczne Neuromed, Bydgoszcz, Not set

COPERNICUS Podmiot Leczniczy Sp. z o.o., Gdańsk, Not set

Novo-Med Zielinski I Wspolnicy Sp. J., Katowice, Not set

NZOZ Neuromed M. i M., Lublin, Not set

Twoja Przychodnia Nowosolskie Centrum Medyczne, Nowa Sól, Not set

Centro Hospitalar Universitário de Coimbra (CHUC), Coimbra, Not set

Hospital da Senhora da Oliveira, Guimarães, Not set

Centro Hospitalar Lisboa Ocidental, Hospital Egas Moniz, Lisboa, Not set

Centre Hospitalar Universitario de Lisboa Norte (CHULN), Lisboa, Not set

Unidade Local de Saúde de Matosinhos, Matosinhos, Not set

Centro Hospitalar Universitário de Santo António, Porto, Not set

Centro Hospitalar de Entre o Douro e Vouga, Santa Maria Da Feira, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario Vithas Madrid La Milagrosa, Madrid, Not set

Hospital Regional Universitario de Málaga, Málaga, Not set

Hospital Clinico Universitario de Valladolid, Valladolid, Not set

Hospital Clinico Viña del Mar, Valparaiso, Not set

University Hospital of Wales, Cardiff, Wales

Mid Yorkshire Hospitals NHS Trust, Wakefield, West Yorkshire

St George's University Hospitals NHS Foundation Trust, London, Not set

University College London Hospitals NHS Foundation Trust, London, Not set

John Radcliffe Hospital, Oxford, Not set

Salford Royal NHS Foundation Trust - Greater Manchester Neuroscience Centre (GMNC), Salford, Not set

Conditions: Primary Generalized Tonic-Clonic Seizures

Learn More ›

Theta-Burst Stimulation for Bipolar Depression

NCT06370988

Recruiting

The purpose of this trial is to determine if intermittent theta-burst stimulation (iTBS) can reduce the symptoms of depression in treatment-resistant bipolar disorder. To do this, some of the participants in this study will receive treatment with active iTBS stimulation, while others will receive sham iTBS stimulation. Participants will come for 30 days of either active iTBS or sham iTBS, with a 6-week follow-up period. Symptoms of depression (for determining treatment efficacy) and mania (for d... Read More

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

06/26/2025

Locations: University Health Network, Toronto, Ontario +1 locations

Conditions: Bipolar Depression, Bipolar Disorder, Treatment- Resistant Bipolar Disorder, Type 2 Bipolar Disorder

Learn More ›

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

NCT03165734

Recruiting

This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count \<50,000/μL). Approximately 399 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 266 patients) or to P/C therapy (approximately 133 patients) Condition or disease: Primary Myelofibrosis/Post-Polycythemia Vera Myelofibrosis/ Post-essential Thromb... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/26/2025

Locations: University of Alabama at Birmingham, (UAB) Hospital, Comprehensive Cancer Center, Birmingham, Alabama +206 locations

University of Alabama at Birmingham, (UAB) Hospital, Comprehensive Cancer Center, Birmingham, Alabama

Mayo Clinic Hospital, Phoenix, Arizona

City of Hope, Duarte, California

USC Norris Comprehensive Cancer Center, Los Angeles, California

UCLA David Geffen School of Medicine, Los Angeles, California

University of Colorado Cancer Center, Aurora, Colorado

Rocky Mountain Cancer Centers (US Oncology/McKesson), Boulder, Colorado

Yale School of Medicine, New Haven, Connecticut

Georgetown University Hospital, Washington, District of Columbia

George Washington University-Medical Faculty Associates, Washington, District of Columbia

Cleveland Clinic Florida, Weston, Florida

Northwestern Memorial Hospital, Chicago, Illinois

Rush University Medical Center, Chicago, Illinois

The University of Chicago Medical Center, Chicago, Illinois

University of Kansas Cancer Center and Medical Pavilion, Westwood, Kansas

Ochsner Medical Center, New Orleans, Louisiana

Saint Agnes Hospital, Baltimore, Maryland

Johns Hopkins University, Baltimore, Maryland

American Oncology Partners of Maryland, PA, Bethesda, Maryland

Regional Cancer Care Associates LLC - CCBD Division, Bethesda, Maryland

Maryland Oncology Hematology, PA- Columbia, Columbia, Maryland

Michigan Medicine Hematology Clinic-Rogel Cancer Center, Ann Arbor, Michigan

Cancer and Hematology Centers of Western Michigan, Grand Rapids, Michigan

Washington University School of Medicine-Siteman Cancer Center, Saint Louis, Missouri

Comprehensive Cancer Centers of Nevada- Twain Office, Las Vegas, Nevada

Hackensack University Medical Center, Hackensack, New Jersey

Columbia University Medical Center, New York, New York

Weill Cornell Medical College, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Memorial Sloan -Kettering Cancer Center, New York, New York

University of Rochester, Rochester, New York

Duke University Hospital, Durham, North Carolina

Cleveland Clinic, Cleveland, Ohio

The James Cancer Hospital and Solove Research Institute, Columbus, Ohio

Oregon Health and Science University, Portland, Oregon

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

The Sarah Cannon Research Institute-Tennessee Oncology, Nashville, Tennessee

The University of Texas MD Anderson Cancer Center, Houston, Texas

Mays Cancer Center, San Antonio, Texas

Texas Oncology- San Antonio, San Antonio, Texas

University of Utah - Huntsman Cancer Institute, Salt Lake City, Utah

Fred Hutchinson Cancer Research Center, Seattle, Washington

Westmead Hospital, Sydney, New South Wales

Alfred Hospital, Malignant Hematology and Stem Cell Transplantation Service, Melbourne, Victoria

The Perth Blood Institute, Perth, Western Australia

Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Not set

Grodno University Hospital, Grodno, Not set

Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology, Minsk, Not set

University Clinical Centre of the Republic of Srpska, Banja Luka, Not set

University Clinical Center of Sarajevo, Sarajevo, Not set

Hospital Sao Rafael, Salvador, Bahia

Integrare Therapeutics, Fortaleza, Ceara

Clinics Hospital, Federal University of Goias - (UFG), Goiana, Goias

Cetus Oncology Inc., Belo Horizonte, Minas Gerais

Clinical Hospital of the Federal University of Parana (HC - UFPR), Curitiba, Parana

Humane Clinic / Atena Research Institute, Mossoró, Rio Grande Do Norte

Hospital Moinhos de Vento, Porto Alegre, Rio Grande Do Sul

Integrated Oncology Center of Rio Grande do Sul - Mother of God Hospital, Porto Alegre, Rio Grande Do Sul

Santa Catarina Health Research and Education Center (CEPEN), Florianópolis, Santa Catarina

State University of Campinas (UNICAMP) - Hemocenter, Campinas, Sao Paulo

Hospital Amaral Carvalho, Jaú, Sao Paulo

Jewish Hospital Albert Einstein, São Paulo, Sao Paulo

Samaritano Hospital, São Paulo, Sao Paulo

Sao Paulo University Clinical Hospital, São Paulo, Sao Paulo

Saint Lucas Hospital of Copacabana, Rio De Janeiro, Not set

University Multiprofile Hospital for Active Treatment "Dr. Georgi Stranski", Pleven, Not set

University Multiprofile Hospital for Active Treatment "Sveti Georgi", Plovdiv, Plovdiv, Not set

Multiprofile Hospital for Active Treatment - Sofia, part of Military Medical Academy, Sofia, Not set

Specialized Hospital for Active Treatment of Hematological Diseases, Sofia, Not set

Multiprofile Hospital for Active Treatment "Sveta Marina", Varna, Not set

Tom Baker Cancer Center, Internal Medicine/Hematology, Calgary, Alberta

University of Alberta, Edmonton, Alberta

Providence Hematology - Vancouver, Vancouver, British Columbia

Eastern Regional Health Authority, Saint John's, Newfoundland and Labrador

Nova Scotia Health Authority, Centre for Clinical Research, Halifax, Nova Scotia

Princess Margaret Cancer Centre, Toronto, Ontario

Jewish General Hospital; Clinical Research Unit, Montreal, Quebec

University Hospital Brno, Brno, Not set

University Hospital Olomouc, Olomouc, Not set

University Hospital Plzen, Pilsen, Not set

University Hospital Kralovske Vinohrady, Clinic of Internal Hematology, Prague, Not set

CHU Hôpital Amiens Sud, Amiens, Not set

La Conception Hospital, Marseille, Not set

CHU de Nimes - Hopital Universitaire Caremeau, Nîmes, Not set

Hôpital Saint-Louis, Paris, Not set

CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque, Pessac, Not set

Centre Hospitalier Lyon-Sud, Pierre Benite, Not set

University Hospital Center of Poitiers, Poitiers, Not set

JSC K. Eristavi National Center For Experimental and Clinical Surgery, Tbilisi, Not set

LTD M.Zodelava's Hematology Center, Department of Hematology, Tbilisi, Not set

LTD S.Khechinashvili University Hospital, Tbilisi, Not set

Malkhaz Katsiashvili Multiprofile Emergency Medicine Center LTD, Tbilisi, Not set

Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic LLC, Tbilisi, Not set

Semmelweis University SE ÁOK I. sz. Belgyógyászati Klinika, Budapest, Not set

University of Debrecen Clinical Center (Debreceni Egyetem Klinikai Központ), Debrecen, Not set

Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár, Not set

Szabolcs-Szatmar-Bereg County Hospitals and University Teaching Hospital, Department of Hematology, Nyíregyháza, Not set

Fejer County St. Gyorgy University Teaching Hospital, Department of Internal Medicine I, Székesfehérvár, Not set

Gauhati Medical College and Hospital, Guwahati, Assam

Nirmal Hospital Pvt Ltd, Sūrat, Gujarat

Fortis Memorial Research Institute(FMRI), Gurgaon, Haryana

Sahyadri Super Speciality Hospital, Pune, Maharashtra

Shri Ram Cancer Centre, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan

Meenakshi Mission Hospital And Research Centre (MMHRC), Madurai, Tamil Nadu

Yashoda Hospitals, Hyderabad, Telangana

All India Institute of Medical Sciences, Dehradun, Uttarakhand

Netaji Subhash Chandra Bose Cancer Research Institute, Kolkata, West Bengal

Tata Medical Center, Kolkata, West Bengal

St. John's Medical College Hospital, Bengaluru, Not set

Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Not set

Max Super Speciality Hospital Saket (A Unit of Max Healthcare Institute Limited), Delhi, Not set

Lady Davis Carmel Medical Center, Department of Hematology,, Haifa, Not set

Hadassah Medical Center, Department of Hematology,, Jerusalem, Not set

Meir Medical Center, Hematology Institute and Blood Bank, Kfar Saba, Not set

Rabin Medical Center, Clinic for Myeloproliferative Disorders, Petah-Tikva, Not set

The Tel Aviv Sourasky Medical Center, Department of Internal Medicine, Tel Aviv, Not set

Cancer Institute "Giovanni Paolo II", IRCCS, Bari, Not set

Polyclinic S. Orsola-Malpighi, Bologna, Not set

ASST Spedali Civili Brescia, Hematology Unit, Brescia, Not set

Azienda Ospedaliero-Universitaria Careggi, Florence, Not set

Scientific Institute of Romagna for the Study and Treatment of Cancer (IRST), IRCCS, Forlì, Not set

Maggiore Polyclinic Hospital, Fondazione IRCCS Ca' Granda, Milan, Not set

ASST Monza - Ospedale San Gerardo, Monza, Not set

University Hospital "Federico II", Naples, Not set

University Hospital "Maggiore della Carita" of Novara, Novara, Not set

United Hospitals Villa Sofia Cervello, Palermo, Not set

Polyclinic San Matteo, IRCCS, Pavia, Not set

Hospital "Infermi" of Rimini, Rimini, Not set

Umberto I Polyclinic of Rome, Rome, Not set

University Polyclinic Foundation "Agostino Gemelli", Rome, Not set

City of Health and Science of Turin, Turin, Not set

Santa Maria della Misericordia University Hospital of Udine, Udine, Not set

ASST Sette Laghi Hospital, Varese, Not set

University of Yamanashi Hospital, Chuo, Not set

Kyushu University Hospital, Fukuoka, Not set

Fukushima Medical University Hospital, Fukushima, Not set

Tohoku University Hospital, Miyagi, Not set

University of Miyazaki Hospital, Miyazaki, Not set

Juntendo University Hospital, Tokyo, Not set

Nippon Medical School Hospital, Tokyo, Not set

Tokyo Medical University Hospital, Tokyo, Not set

Mie University Hospital, Tsu, Not set

Ehime University Hospital, Tōon, Not set

Aktobe Medical Center, Department of Hematology, Aktobe, Not set

City Clinical Hospital #7, Hematology Department, Almaty, Not set

Center for Hematology, Astana, Not set

National Research Oncology, Oncohematology Center, Astana, Not set

Hematology Center, Karaganda, Not set

City Oncological Center, Shymkent, Not set

Center for Hematology, Ust-Kamenogorsk, Not set

Pusan National University Hospital, Busan, Not set

Kyungpook National University Hospital, Daegu, Not set

Severance Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Seoul National University Hospital, Seoul, Not set

The Catholic University of Korea, St. Mary's Hospital, Seoul, Not set

University Teaching Hospital in Bialystok, Białystok, Not set

University Clinical Center in Gdansk, Gdańsk, Not set

Andrzej Mielecki Independent Public Clinical Hospital of Medical University of Silesia in Katowice, Department of Hematology and Bone Marrow Transplantation, Katowice, Not set

Pratia Oncology Katowice, Katowice, Not set

University Hospital in Krakow, Kraków, Not set

Independent Public Teaching Hospital No.1 in Lublin, Department of Hematooncology, Bone Marrow Transplantation and Chemotherapy, Lublin, Not set

Jedrzej Sniadecki Specialist Hospital in Nowy Sacz, Department of Hematology, Nowy Sącz, Not set

Frederic Chopin Provincial Teaching Hospital No. 1 in Rzeszow, Department of Hematology,, Rzeszów, Not set

Nasz Lekarz Medical Outpatient Clinics Slawomir Jeka, Toruń, Not set

Institute of Hematology and Transfusion Medicine, Teaching Department of Hematology, Warsaw, Not set

Jan Mikulicz Radecki University Hospital in Wroclaw, Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wrocław, Not set

Nicolaus Copernicus Provincial Multispecialty Oncology and Traumatology Center in Lodz, Łódź, Not set

Onco Card Srl, Braşov, Not set

Coltea Clinical Hospital, Bucharest, Not set

Fundeni Clinical Institute, Bucharest, Not set

Prof. Dr. Ion Chiricuta" Institute of Oncology, Cluj-Napoca, Not set

City Clinical Hospital #40, Moscow, Not set

City Clinical Hospital n.a. V.V. Veresaev of the Moscow City Health, Moscow, Not set

S.P. Botkin City Clinical Hospital, Moscow, Not set

Clinic UZI 4D, LLC, Pyatigorsk, Not set

Research Institute of Hematology and Transfusiology, Saint Petersburg, Not set

S.M. Kirov Military Medical Academy, Department and Clinic for Intermediate-Level Training in Internal Medicine, Hematology Division, Saint Petersburg, Not set

V.A. Almazov North-West Federal Medical Research Center, Institute of Oncology and Hematology, Scientific Department of Clinical Oncology, Saint Petersburg, Not set

Bashkiria State Medical University, Department of Internal Medicine, Ufa, Not set

Volgograd Regional Clinical Oncology Center, Volgograd, Not set

Clinical Center of Serbia, Clinic of Hematology, Belgrade, Not set

Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad, Not set

Hospital del Mar, Barcelona,, Not set

Hospital Clínic de Barcelona, Barcelona, Not set

University Hospital Vall d'Hebron, Barcelona, Not set

Hospital Universitario Ramón y Cajal, Madrid, Not set

University Hospital 12 de Octubre, Department of Hematology, Madrid, Not set

Morales Meseguer University General Hospital, Department of Hematology and Hemotherapy, Murcia, Not set

University Clinical Hospital of Salamanca, Department of Hematology, Salamanca, Not set

University Hospital Virgen del Rocio (HUVR), Seville, Not set

University Clinical Hospital of Valencia, Department of Hematology and Medical Oncology, Valencia, Not set

Cherkasy Regional Oncology Dispensary of Cherkasy Oblast Council, Regional Treatment and Diagnostic Hematology Center, Department of Hematology, Cherkasy, Not set

City Clinical Hospital #4" under Dnipro City Council, Dnipro, Not set

Communal Non-profit enterprise "Regional Center of Oncology", Department of Hematology, Kharkiv, Not set

Kyiv City Clinical Hospital #9, Hematology Department #1, Kyiv, Not set

Kyiv Regional Oncology Center, Department of Hematology,, Kyiv, Not set

Limited Liability Company "City Doctor", Kyiv, Not set

Institute of Blood Pathology and Transfusion Medicine, Department of Hematology, Lviv, Not set

Poltava M.V. Sklifosovskyi Regional Clinical Hospital under Poltava Regional Council, Department of Hematology, Poltava, Not set

Royal Hallamshire Hospital, Department of Hematology, Sheffield, South Yorkshire

Beatson West of Scotland Cancer Centre, Glasgow, Not set

Gloucestershire Royal Hospital, Gloucester, Not set

Barts Health NHS Trust - The Royal London Hospital, London, Not set

Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital, London, Not set

Imperial College Healthcare NHS Trust - Hammersmith Hospital, London, Not set

Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford, Not set

Conditions: Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis

Learn More ›

ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

NCT05671510

Recruiting

The goal of this Phase 3 clinical trial is study the safety and efficacy of the nextgen anti-CTLA-4 antibody, gotistobart (ONC-392/BNT316), in patients with metastatic non-small cell lung cancer who have disease progressed on anti-PD-1/PD-L1 antibody based therapy. The study will test whether gotistobart, in comparison with chemotherapy agent docetaxel, could prolong the life for NSCLC patients. Patients will be randomized to be treated with either gotistobart or docetaxel, IV infusion, once eve... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/26/2025

Locations: XCancer/Dothan Hematology & Oncology - 1114, Dothan, Alabama +159 locations

XCancer/Dothan Hematology & Oncology - 1114, Dothan, Alabama

Genesis Cancer and Blood Institute - 1123, Russellville, Arkansas

The Oncology Institute (TOI) Clinical Research - 1109, Cerritos, California

Emad Ibrahim MD Inc. - 1147, Redlands, California

UC Davis Comprehensive Cancer Center - 1103, Sacramento, California

Bass Medical Group - 1155, Walnut Creek, California

Nuvance Health - 1118, Norwalk, Connecticut

D&H Cancer Research Center LLC - 1153, Margate, Florida

Ocala Oncology Center PL - 1102, Ocala, Florida

AdventHealth Cancer Institute - 1105, Orlando, Florida

Orlando Health - 1130, Orlando, Florida

Florida Cancer Specialists -South - 1126, Sarasota, Florida

Florida Cancer Specialists -North - 1125, The Villages, Florida

Florida Cancer Specialists -East - 1124, West Palm Beach, Florida

Orchard Healthcare Research, Inc. - 1116, Skokie, Illinois

Springfield Clinic - The Cancer Center - 1110, Springfield, Illinois

Fort Wayne Medical Oncology - 1133, Fort Wayne, Indiana

Deaconess Chancellor Center for Oncology - 1131, Newburgh, Indiana

Alliance for Multispecialty Research, LLC - 1144, Merriam, Kansas

Cotton O'Neil Clinical Research Center - 1151, Topeka, Kansas

University of Kentucky - Markey Cancer Center - 1112, Lexington, Kentucky

Norton Cancer Institute - 1108, Louisville, Kentucky

Hematology Oncology Clinics - Baton Rouge - 1142, Baton Rouge, Louisiana

HealthPartners Institute, Cancer Research Center - 1143, Saint Louis Park, Minnesota

Jefferson City Medical Group - 1145, Jefferson City, Missouri

NHO-Revive Research Institute, LLC - 1152, Lincoln, Nebraska

Astera Cancer Care - 1128, East Brunswick, New Jersey

Messino Cancer Centers - 1121, Asheville, North Carolina

University of Cincinnati Cancer Center - 1107, Cincinnati, Ohio

The Ohio State University James Cancer Center - 1104, Columbus, Ohio

Miami Valley Hospital - 1115, Dayton, Ohio

Tri County Hematology & Oncology Associates, Inc - 1156, Massillon, Ohio

Oncology Associates of Oregon - 1138, Eugene, Oregon

Pennsylvania Cancer Specialists Research Institute - 1101, Gettysburg, Pennsylvania

Donald Guthrie Foundation - 1135, Sayre, Pennsylvania

Cancer Care Associates of York, Inc. - 1113, York, Pennsylvania

University of Tennessee Medical Center - 1146, Knoxville, Tennessee

Sarah Cannon Research Institute - Tennessee Oncology at Nashville - 1119, Nashville, Tennessee

Texas Oncology -Dallas - 1127, Dallas, Texas

Texas Oncology - Baylor Charles A. Sammons Cancer Center (USOR) - 1140, Dallas, Texas

Texas Oncology - Denison - 1139, Denison, Texas

Texas Oncology - Fort Worth Cancer Center - 1141, Fort Worth, Texas

Oncology Consultants, P.A. - 1120, Houston, Texas

Texas Oncology - McAllen - 1132, McAllen, Texas

Texas Oncology - Plano West - 1137, Plano, Texas

Texas Oncology -San Antonio - 1122, San Antonio, Texas

Texas Oncology - Northeast Texas - Tyler - 1134, Tyler, Texas

NEXT Oncology - Virginia - 1129, Fairfax, Virginia

Virginia Cancer Institute - 1149, Henrico, Virginia

Virginia Oncology Associates - 1136, Norfolk, Virginia

MultiCare Institute for Research and Innovation - Tacoma - 1148, Spokane, Washington

Bankstown Hospital - 3305, Bankstown, New South Wales

Newcastle Private Hospital - 3302, New Lambton Heights, New South Wales

Mater - 3301, Newstead, Queensland

Cancer Research SA - 3303, Adelaide, South Australia

AZ Maria Middelares - 2104, Gent, Not set

Jessa Ziekenhuis (Jessa Hospital) - Campus Salvator - 2102, Hasselt, Not set

C. H. R. de la Citadelle - 2103, Liège, Not set

Vitaz - Sint-niklaas Moerland - 2101, Sint-Niklaas, Not set

BC Cancer Centre - Kelowna - 1203, Kelowna, British Columbia

Saskatchewan Cancer Agency - Regina - 1201, Regina, Saskatchewan

Saskatchewan Cancer Agency - Saskatoon Cancer Centre - 1202, Saskatoon, Saskatchewan

Santa Cabrini Hospital - 1204, Québec, Not set

The First Affiliated Hospital of Anhui Medical University - 3221, Hefei, Anhui

Anhui Medical University - The Second Hospital - 3222, Hefei, Anhui

Beijing Cancer Hospital - 3205, Beijing, Beijing

Cancer Hospital, Chinese Academy of Medical Sciences - 3211, Beijing, Beijing

Fujian Medical University Union Hospital - 3225, Fuzhou, Fujian

The First Affiliated Hospital of Xiamen University - 3210, Xiamen, Fujian

Dongguan People's Hospital - 3206, Dongguan, Guangdong

Guangdong Provincial People's Hospital - 3201, Guangzhou, Guangdong

Zhujiang Hospital of Southern Medical University - 3203, Guangzhou, Guangdong

The First Affiliated Hospital of Guangdong Pharmaceutical University - 3215, Guangzhou, Guangdong

The People's Hospital of Guangxi Zhuang Autonomous Region - 3228, Nanning, Guangxi

Hainan General Hospital - 3202, Haikou, Hainan

Affiliated Hospital of Hebei University - 3214, Zhengzhou, Hebei

The Affiliated Tumor Hospital of Harbin Medical University - 3232, Harbin, Heilongjiang

Henan Cancer Hospital - 3226, Zhengzhou, Henan

The First Affliated Hospital of Zhengzhou University - 3207, Zhengzhou, Henan

Renmin Hospital of Wuhan University - 3216, Wuhan, Hubei

Union Hospital Tongji Medical College - 3212, Wuhan, Hubei

Xiangya Hospital, Central South University - 3223, Changsha, Hunan

Hunan Cancer Hospital - 3209, Changsha, Hunan

The Second Affiliated Hospital of Soochow University - 3217, Suzhou, Jiangsu

Xuzhou Medical University - The Affiliated Hospital - 3234, Xuzhou, Jiangsu

The Second Affiliated Hospital of Nanchang University - 3224, Nanchang, Jiangxi

Jinan Central Hospital - 3230, Jinan, Shandong

Shanxi Bethune Hospital - 3233, Taiyuan, Shanxi

The First Affiliated Hospital of Xi'an Jiaotong University - 3218, Xi'an, Shanxi

Chengdu Seventh People's Hospital - 3229, Chengdu, Sichuan

Sichuan Cancer Hospital - 3227, Chengdu, Sichuan

Chongqing University Cancer Hospital - 3213, Chongqing, Sichuan

Tianjin Medical University Cancer Institute and Hospital - 3208, Tianjin, Tianjin

Yunnan Cancer Hospital - 3231, Kunming, Yunnan

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine - 3219, Hangzhou, Zhejiang

The Second Affiliated Hospital of Zhejiang University School of Medicine - 3220, Hangzhou, Zhejiang

Zhejiang Cancer Hospital - 3204, Hangzhou, Zhejiang

China-Japan Friendship Hospital - 3236, Beijing, Not set

West China Hospital, Sichuan University - 3238, Chengdu, Not set

Nanjing Medical University (NMU) - Nanjing First Hospital - 3239, Jiangse, Not set

Weifang Second People's Hospital - 3235, Shandong, Not set

Tongji University - Shanghai Oriental Hospital (Shanghai East Hospital) - 3240, Shanghai, Not set

Hubei Cancer Hospital - 3237, Wuhan, Not set

Städt. Klinikum München GmbH - 2204, Bogenhausen, Not set

Kliniken Essen-Mitte - 2206, Essen, Not set

Klinikum Esslingen GmbH - 2201, Esslingen am Neckar, Not set

Lungenfachklinik Immenhausen - 2202, Immenhausen, Not set

Klinikverbund Allgaü - Klinikum Kempten - 2205, Immenstädt, Not set

Asklepios Fachkliniken Muenchen-Gauting - 2203, Muenchen-Gauting, Not set

Clinica Oncologica Ospedali Riuniti Ancona - 2311, Ancona, Not set

IRCCS Istituto Tumori Giovanni Paolo II - 2306, Bari, Not set

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - 2310, Bergamo, Not set

Azienda Ospedaliera Papardo - 2301, Messina, Not set

Ospedale San Raffaele - 2307, Milano, Not set

Fondazione IRCCS Instituto Tumori Di Milano - 2305, Milano, Not set

Ospedale San Gerardo di Monza - 2302, Monza, Not set

Azienda Ospedaliera Universitaria "Federico II" - 2304, Naples, Not set

AOU Policlinico Giaccone, Università di Palermo - 2309, Palermo, Not set

Universita degli Studi di Perugia - Ospedale Santa Maria della Misericordia - 2308, Perugia, Not set

Universita Campus Bio-medico Di Roma (UCBM) - Policlinico Universitario - 2303, Roma, Not set

Chungbuk National University Hospital - 3101, Cheongju-si, Not set

Keimyung University Dongsan Hospital - 3102, Daegu, Not set

National Cancer Center - 3107, Goyang-si, Not set

Severance Hospital, Yonsei University Health System - 3104, Seoul, Not set

Asan Medical Centre - 3103, Seoul, Not set

Korea University Guro Hospital - 3106, Seoul, Not set

The Catholic University of Korea, St Vincent's Hospital - 3105, Suwon, Not set

Antoni van Leeuwenhoek - 2703, Amsterdam, Not set

Rijnstate Ziekenhuis - 2701, Arnhem, Not set

Jeroen Bosch Ziekenhuis - 2702, Herzogenbusch, Not set

ETZ Elisabeth - 2704, Tilburg, Not set

Hospital General Universitario de Elche - 2401, Elche, Not set

Hospital Universitario Lucus Augusti - 2405, Lugo, Not set

Hospital General Universitario Gregorio Marañon - 2404, Madrid, Not set

Hospital Regional Universitario de Malaga - 2403, Málaga, Not set

Hospital General Universitario de Valencia - 2406, Valencia, Not set

Fundacion Instituto Valenciano De Oncologia (IVO) - 2402, Valencia, Not set

Adana Sehir Hastanesi - 2602, Adana, Not set

Baskent University Adana - 2601, Adana, Not set

Hacettepe Universitesi - 2609, Ankara, Not set

Ankara Bilkent Sehir Hastanesi - 2610, Ankara, Not set

Akdeniz University Medical Hospital - 2606, Antalya, Not set

Ege Universitesi Hastanesi - 2612, Bornova, Not set

Trakya University Faculty of Medicine Edirne - 2608, Edirne, Not set

Istanbul Üniversitesi Onkoloji Enstitüsü - 2613, Fatih, Not set

Koc Universitesi - 2611, Istanbul, Not set

Göztepe Prof Dr. Suleyman Yalcin City Hospital - 2605, Istanbul, Not set

Istanbul Bakirkoy Sadi Konuk - 2604, Istanbul, Not set

Medipol University Medical Faculty Hospital - 2603, Istanbul, Not set

Izmir Ekonomi Universitesi Medical Point Hastanesi - 2607, İzmir, Not set

University Hospital Birmingham (UHB) / Queen Elizabeth Hospital Birmingham - 2801, Birmingham, England

Cambridge University Hospitals - 2804, Cambridge, England

Royal Devon University Healthcare NHS - 2808, Exeter, England

University Hospital Leicester - 2806, Leicester, England

The Christie NHS Foundation Trust - 2803, London, England

Barts Health NHS Trust (St. Bartholomew's Hospital) - 2802, Manchester, England

South Tees Hospitals - 2807, Middlesbrough, England

Torbay Hospital - Horizon Centre - 2805, Torquay, England

Edinburgh Cancer Centre - 2809, Edinburgh, Scotland

University College London Hospital - 2811, London, Not set

Conditions: Non Small Cell Lung Cancer

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Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

NCT05904028

Recruiting

Home optical coherence tomography- guided treatment versus treat and extend for the management of neovascular age-related macular degeneration.

Gender:

ALL

Ages:

50 years and above

Trial Updated:

06/26/2025

Locations: Kent W. Small, MD, AMC, Glendale, California +55 locations

Kent W. Small, MD, AMC, Glendale, California

Loma Linda University, Loma Linda, California

East Bay Retina Consultants, Inc., Oakland, California

Southern California Desert Retina Consultants, Inc., Palm Desert, California

UC Davis Health Eye Center, Sacramento, California

Macula Retina Vitreous Institute, Torrance, California

Bay Area Retina Associates A Medical Group, Walnut Creek, California

Retina Consultants, Manchester, Connecticut

National Ophthalmic Research Institute, Fort Myers, Florida

University of Florida- Jacksonville, Jacksonville, Florida

Florida Retina Institute, James A. Staman, MD, PA- Jacksonville, Jacksonville, Florida

Argus Research Center, Inc, Naples, Florida

Southeast Eye Institute, P.A. dba Eye Associates of Pinellas, Pinellas Park, Florida

Retina Associates of Sarasota, Sarasota, Florida

Retina Associates of Florida, LLC, Tampa, Florida

Southeast Retina Center, P.C., Augusta, Georgia

Thomas Eye Group, Sandy Springs, Georgia

Rush University Medical Center, Chicago, Illinois

UIC - Dept of Ophthalmology & Visual Sciences, Chicago, Illinois

The Trustees of Indiana University, Indianapolis, Indiana

Midwest Eye Institute, Indianapolis, Indiana

Wolfe Clinic, P.C.- West Des Moines, West Des Moines, Iowa

Mid-America Retina Consultants, P.A., Overland Park, Kansas

Elman Retina Group, BA, Baltimore, Maryland

Johns Hopkins University, Baltimore, Maryland

Valley Eye Physicians and Surgeons, Ayer, Massachusetts

Joslin Diabetes Center, Boston, Massachusetts

Henry Ford Health System, Detroit, Michigan

Retina Associates of Michigan, Grand Blanc, Michigan

Associated Retinal Consultants, P.C., Royal Oak, Michigan

Associated Retinal Consultants, Traverse City, Michigan

The Retina Institute, St. Louis, Missouri

Associated Retinal Surgeons d/b/a Mid Atlantic Retina, Cherry Hill, New Jersey

Macula Care, New York, New York

Retina Associates of Western NY, P.C., Rochester, New York

The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio

Retina Vitreous Center, Edmond, Oklahoma

Verum Research LLC, Eugene, Oregon

Oregon Health & Science University, Portland, Oregon

Cascade Medical Research Institute, LLC, Springfield, Oregon

Retina Vitreous Consultants, Monroeville, Pennsylvania

The Trustees of the University of Pennsylvania, Philadelphia, Pennsylvania

Hilton Head Retina Institute, Hilton Head Island, South Carolina

Ophthalmology Ltd., Sioux Falls, South Dakota

Southeastern Retina Associates, P.C., Knoxville, Tennessee

Austin Research Center for Retina, Austin, Texas

Retina Consultants of Texas, PA, Bellaire, Texas

Southwest Retina Consultants, El Paso, Texas

Baylor College of Medicine, Baylor Eye Physicians and Surgeons, Houston, Texas

Texas Retina Associates, Lubbock, Texas

Retinal Consultants of Texas, San Antonio, Texas

The Board of Regents of the University of Wisconsin System, Madison, Wisconsin

Eye Clinic of Wisconsin, Wausau, Wisconsin

Chow Berger Koushan Medicine Professional Corporation o/a Toronto Retina Institute, North York, Ontario

University Health Network, Toronto, Ontario

Conditions: Neovascular Age-related Macular Degeneration

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A Study of TLN-254 in Participants With Relapsed or Refractory T-cell Lymphoma

NCT06733441

Recruiting

The primary purpose of this study is to evaluate the anti-tumor activity of TLN-254 monotherapy in participants with relapsed or refractory T-cell lymphoma.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/26/2025

Locations: Washington University School of Medicine, St. Louis, Missouri +3 locations

Conditions: Lymphoma

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Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

NCT04614103

Recruiting

This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-cell lung cancer

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

06/25/2025

Locations: City of Hope, Duarte, California +63 locations

City of Hope, Duarte, California

UC San Diego Moores Cancer Center, La Jolla, California

University of Southern California, Los Angeles, California

Christiana Care Health System, Newark, Delaware

University of Florida Health Cancer Center, Gainesville, Florida

Sylvester Comprehensive Cancer Center, Miami, Florida

AdventHealth Cancer Institute, Orlando, Florida

H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida

Augusta University, Augusta, Georgia

Rush University Medical Center, Chicago, Illinois

University of Illinois Hospital & Health Sciences System, Chicago, Illinois

Advocate Aurora Health, Park Ridge, Illinois

University of Louisville, Louisville, Kentucky

University of Maryland, Baltimore, Maryland

Dana Farber Cancer Institute, Boston, Massachusetts

Karmanos Cancer Institute, Detroit, Michigan

Henry Ford Health System, Detroit, Michigan

University of Minnesota, Minneapolis, Minnesota

University of Nebraska Medical Center, Omaha, Nebraska

MD Anderson Cooper, Camden, New Jersey

Roswell Park Cancer Institute, Buffalo, New York

New York University Langone Medical Center, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

University of Rochester Medical Center, Rochester, New York

University of North Carolina, Chapel Hill, North Carolina

Novant Health - Charlotte, Charlotte, North Carolina

Novant Health - Winston-Salem, Winston-Salem, North Carolina

Atrium Health Wake Forest University Health Sciences, Winston-Salem, North Carolina

Sanford Roger Maris Cancer Center, Fargo, North Dakota

University of Cincinnati Medical Center, Cincinnati, Ohio

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

University of Oklahoma, Oklahoma City, Oklahoma

Oregon Health and Science University, Portland, Oregon

Allegheny General Hospital, Natrona Heights, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Sanford Cancer Center, Sioux Falls, South Dakota

Avera Medical Group Cancer Institute, Sioux Falls, South Dakota

University of Tennessee Medical Center, Knoxville, Tennessee

Baptist Cancer Center, Memphis, Tennessee

Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas

Houston Methodist, Houston, Texas

VCU Medical Center (Virginia Commonwealth University), Richmond, Virginia

Seattle Cancer Care Alliance, Seattle, Washington

St. Vincent's Hospital, Darlinghurst, New South Wales

Westmead Hospital, Westmead, New South Wales

Hollywood Private Hospital Ramsay, Nedlands, Western Australia

Princess Margaret Cancer Centre, Toronto, Ontario

Centre Hospitalier de l'Universite de Montreal (CHUM), Montréal, Not set

Universitätsklinikum Bonn, Bonn, Not set

Universitätsklinikum Carl Gustav Carus, MK I, Dresden, Not set

Universitätsklinikum Mannheim, Mannheim, Not set

Samsung Medical Center, Seoul, Gangnam-gu

Gachon Unversity Gil Medical Center, Incheon, Not set

Severance Hospital, Yonsei University, Seoul, Not set

Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, Not set

National Cancer Centre Singapore, Singapore, Not set

Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Vaud

University Hospital of Zurich/ Universitätsspital Zürich, Zürich, Not set

Royal Marsden Hospital, Chelsea, England

Sarah Cannon Research Institute, London, England

University College London, London, England

The Christie NHS Foundation Trust, Manchester, England

Guy's Hospital, London, Not set

Conditions: Metastatic Non Small Cell Lung Cancer

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Type 1 Diabetes, Exercise and Mentoring Trial

NCT06296992

Recruiting

The proposed study aims to improve the psychosocial health of adolescents living with type 1 diabetes (T1D). The study will generate knowledge and support knowledge mobilization about the effectiveness of a novel model of care for psychosocial health and self-management for adolescents living with type 1 diabetes (T1D). The novel model of care is the recruitment and training if young adult mentors to deliver a behavioural intervention that empowers adolescents with T1D to increase daily physical... Read More

Gender:

ALL

Ages:

Between 13 years and 17 years

Trial Updated:

06/25/2025

Locations: the Children's Hospital Research Institute of Manitoba and the University of Manitoba, Winnipeg, Manitoba +1 locations

Conditions: Type 1 Diabetes, Physical Activity

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Safety, Pharmacokinetics, and Efficacy of AT 1501 in Patients Undergoing Kidney Transplant

NCT05027906

Recruiting

This study will evaluate the safety, PK, and efficacy of AT 1501 in patients undergoing kidney transplantation.

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

06/25/2025

Locations: University of Cincinnati, Cincinnati, Ohio +8 locations

Conditions: Prevention of Rejection in Kidney Transplant

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Effects of Exercise on Thoracic Aneurysms

NCT04197648

Recruiting

Thoracic aneurysm incidence is estimated to 4.5 cases per 100 000. The manifestation as well as natural history of thoracic aneurysm depend on many factors such as its localisation, its diameter, presence of collagen disease and family history. For the ascendant aortic aneurysm, it is often linked to a degeneration of the media arterial layer of the arterial wall. The media degeneration is cause by the degeneration of the elastic fibres, which lead to a weakening of the arterial wall accompanied with dilation. This process is often due to age and is accelerated by high blood pressure. Amongst the numerous factors causing the aneurysm, the investigators find: hypertension, aortic bicuspid valve, smoking, atherosclerosis, trauma and genetic predisposition. The average growth rate of thoracic aneurysm is 0.1-0.2 cm/year. The risk of rupture is associated to the size of the aneurysm as well as patient's symptoms. The ruptures and dissections rates are accounted for 2-3/year for thoracic aneurysm between 5.5-6.0 cm in diameter. The patients are often limited in their daily life activities considering their concern and risk of rupture and/or dissect. The effects of exercise on the progression of the aneurysm dilation in patients with thoracic ascendant aortic aneurysm are unknown. It is well known that high blood pressure is a risk factor for rupture of the aortic aneurysm. Many studies have demonstrated the benefits of physical exercise regarding the lowering impact of blood pressure in a cardiac hypertensive population. At 3 and 6 months of the intervention, the subjects in the exercise group will have: 1) a lowered blood pressure at rest and during exercise, 2) maintenance/ improvement of muscle strength, 3) improvement of aerobic exercise capacity (VO2max), and 4) aortic dilation that remained stable or comparable to the control group. The research objective is to measure and compare to a control group, the effects of an exercise program on the following parameters: blood pressure response at rest and during exercise, as well as the VO2max at 3 and 6 months time of the intervention. This randomised and prospective study will take place at the " Institut Universitaire de Cardiologie et de Pneumologie du Québec (IUCPQ) " and will include patients who have a non-surgical ascendant thoracic aortic aneurysm (ATAA). The selected subjects will be randomised into two groups: 1) exercise group (n=15), and 2) control group (n=15). Both groups will be met prior to the intervention (baseline) and at 3 and 6 months time of the intervention, and measures described below will be recorded. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/25/2025

Locations: Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec, Quebec +1 locations

Conditions: Thoracic Aortic Aneurysm

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