Clinical Trials & Research Studies in Canada(Updated 8/25)

@neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms

NCT05526352

Recruiting

The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA). The SwissNeuroFoundation AneurysmDataBase are concerned with generating the data with which to populate this database. The purpose for populating the database are to: * Screen for and evaluate markers of risk for intracranial aneurysm formation and aneurysm rupture. Are considered as mar... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/17/2025

Locations: University of California, San Francisco, California +20 locations

Conditions: Intracranial Aneurysm

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A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis

NCT06294925

Recruiting

The purpose of this real world non-interventional study is to learn about the effects of etrasimod as treatment for patients with moderate to severe ulcerative colitis. Patients will be treated according to standard of care and will only be included in the study if etrasimod is the best treatment choice according to the treating physician. Additionally, patients have to be between 18 and 65 years of age and should not have taken etrasimod in the past. All patients will be prescribed etrasimod... Read More

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

06/17/2025

Locations: Vancouver Coastal Health, Vancouver, British Columbia +30 locations

Vancouver Coastal Health, Vancouver, British Columbia

Providence Health Care (PHC), Vancouver, British Columbia

Gastroenterologie OpernstraBe, Kassel, Hessen

MVZ Gastroenterologie Aachen, Aachen, Not set

Praxis Heil und Müller, Andernach, Not set

MVZ für Gastroenterologie am Bayerischen Platz, Berlin, Not set

MVZ Dachau, Dachau, Not set

Interdisziplinares Crohn Colitis Centrum, Frankfurt am Main, Not set

Facharztpraxis für Gastroenterologie, Grevenbroich, Not set

Studiengesellschaft BSF UG., Halle (Saale), Not set

Praxis für Gasteroenterologie, Heidelberg, Not set

Evangelisches Krankenhaus Kalk, Koeln, Not set

Praxis für Gasteroenterologie Lübeck, Lübeck, Not set

Klinikum Lüneburg, Lüneburg, Not set

Internistische Praxengemeinschaft Oldenburg, Oldenburg, Not set

Magen-Darm-Zentrum Remscheid, Remscheid, Not set

CED am Rhein, Wesseling, Not set

NHS Greater Glasgow and Clyde, Glasgow, Lanarkshire

Nottingham University Hospitals NHS Trust, Queens Medical Centre, Nottingham, Nottinghamshire

Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire

Western General Hospital, Edinburgh, Scotland

Northern Care Alliance NHS Foundation Trust, Greater Manchester, Crumpsall, Not set

Tunbridge Wells Hospital, Kent, Not set

Barts Health NHS Trust, The Royal London Hospital, London, Not set

St. Mark's Hospital, London, Not set

University College London Hospital, London, Not set

St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust, London, Not set

Kings College Hospital, London, Not set

St George's Hospital - St George's Healthcare Nhs Trust, London, Not set

Imperial College Healthcare NHS, London, Not set

Southampton University Hospitals NHS Trust, Southampton, Not set

Conditions: Colitis, Ulcerative

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Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple Myeloma

NCT06421675

Recruiting

A phase II study of single agent elranatamab in patients with relapsed and/or refractory multiple myeloma (MM) who have previously received at least three classes of therapeutic agents and are refractory to the last line of treatment. The primary objective of this study is to improve the tolerability and safety of elranatamab in patients with relapsed and/or refractory multiple myeloma by evaluating an outpatient and intermittent dosing strategy.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/17/2025

Locations: Arnie Charbonneau Cancer Institute, Calgary, Alberta +5 locations

Conditions: Refractory Multiple Myeloma

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Surveillance of Complex Renal Cysts - The SOCRATIC Study

NCT04558593

Recruiting

One third of individuals aged \>60 years will be diagnosed with at least one renal cyst following abdominal imaging. These cystic lesions are categorized according to the Bosniak classification which categorizes cysts according to their degree of complexity and risk of malignancy. Growing evidence suggests that a significant proportion of Bosniak III and IV cysts are benign and that the malignant ones present low metastatic potential. Since renal surgery carries substantial morbidity (20%) and p... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/17/2025

Locations: Prostate Cancer Center, Calgary, Alberta +17 locations

Conditions: Complex Renal Cyst

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National Collaborative to Improve Care of Children With Complex Congenital Heart Disease

NCT02852031

Recruiting

The purpose of this initiative is to improve care and outcomes for infants with HLHS by expanding the NPC-QIC national registry to gather clinical care process, outcome, and developmental data on infants with HLHS between diagnosis and 12 months of age, by improving the use of standards into everyday practice across pediatric cardiology centers, and by engaging parents as partners in the process.

Gender:

ALL

Ages:

15 months and below

Trial Updated:

06/16/2025

Locations: Children's of Alabama, Birmingham, Alabama +62 locations

Children's of Alabama, Birmingham, Alabama

Phoenix Children's Hospital, Phoenix, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

Children's Hospital Los Angeles, Los Angeles, California

UCLA Mattel Children's Hospital, Los Angeles, California

Lucile Packard Children's Hospital-Stanford, Palo Alto, California

Sutter Medical Center-Sacramento, Sacramento, California

UC Davis Children's Hospital, Sacramento, California

Rady Children's Hospital, San Diego, California

Children's Hospital Colorado, Aurora, Colorado

Nemours Cardiac Center, A.I DuPont Hospital for Children, Wilmington, Delaware

Children's National Medical Center, Washington DC, District of Columbia

University of Florida-UF Health, Gainesville, Florida

Nicklaus Children's Hospital, Miami, Florida

Arnold Palmer Children's Hospital, Orlando, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Children's Healthcare of Atlanta, Atlanta, Georgia

Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

Advocate Children's Hospital, Oak Lawn, Illinois

Riley Hospital for Children at IU Health, Indianapolis, Indiana

University of Iowa Children's Hospital, Iowa City, Iowa

Norton Children's Hospital, Louisville, Kentucky

Ochsner Hospital For Children, Jefferson, Louisiana

Children's Hospital New Orleans, New Orleans, Louisiana

University of Maryland Children's Hospital, Baltimore, Maryland

Boston Children's Hospital, Boston, Massachusetts

University of Michigan C.S. Mott Children's Hospital, Ann Arbor, Michigan

Children's Hospital and Clinics of Minnesota, Minneapolis, Minnesota

University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota

Batson Children's Hospital-University of Mississippi Medical Center, Jackson, Mississippi

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

St. Louis Children's Hospital, Saint Louis, Missouri

Children's Hospital and Medical Center-Omaha, Omaha, Nebraska

The Children's Hospital of Montefiore, Bronx, New York

Cohen Children's Medical Center Northwell Health, New Hyde Park, New York

NYU Medical Center, New York, New York

Columbia University- NY Presbyterian, New York, New York

University of Rochester Medical Center, Rochester, New York

Levine Children's Hospital-Sanger Heart and Vascular Institute, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

Akron Children's Hospital, Akron, Ohio

Cincinnati Children's Hospital, Cincinnati, Ohio

University Hospitals Case Medical Center - Rainbow Babies & Children's Hospital, Pediatric Heart Center, Cleveland, Ohio

Cleveland Clinic Children's Hospital, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Doernbecher Children's Hospital, Portland, Oregon

PennState Hershey Medical Center--PennState Health Children's Hospital, Harrisburg, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

Le Bonheur Children's Hospital, Memphis, Tennessee

Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee

Children's Medical Center of Dallas, Dallas, Texas

Cook Childrens Medical Center, Fort Worth, Texas

Texas Children's Hospital, Houston, Texas

Primary Children's Hospital, Salt Lake City, Utah

UVA Children's Hospital, Charlottesville, Virginia

Inova Children's Hospital, Falls Church, Virginia

Seattle Children's Hospital, Seattle, Washington

University of Wisconsin, American Family Children's, Madison, Wisconsin

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

The Hospital for Sick Kids- University of Toronto, Toronto, Ontario

Evelina London Children's Healthcare, London, Not set

Conditions: Hypoplastic Left Heart Syndrome (HLHS)

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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT06297226

Recruiting

The purpose of this study is to evaluate the effectiveness and safety of Arlocabtagene Autoleucel (BMS-986393) in participants with relapsed or refractory multiple myeloma.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/16/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama +51 locations

University of Alabama at Birmingham, Birmingham, Alabama

Banner MD Anderson Cancer Center, Gilbert, Arizona

University of Arkansas for Medical Sciences, Little Rock, Arkansas

UCLA Hematology/Oncology - Westwood (Building 200 Suite 214), Los Angeles, California

UCSF Helen Diller Medical Center at Parnassus Heights, San Francisco, California

Colorado Blood Cancer Institute, Denver, Colorado

Mayo Clinic in Florida, Jacksonville, Florida

Miami Cancer Institute at Baptist Health, Inc., Miami, Florida

Moffitt Cancer Center, Tampa, Florida

Winship Cancer Institute of Emory University, Atlanta, Georgia

Northside Hospital, Atlanta, Georgia

Northwestern Memorial Hospital, Chicago, Illinois

University of Chicago Medical Center, Chicago, Illinois

University of Iowa, Iowa City, Iowa

The University of Kansas Cancer Center - Westwood, Westwood, Kansas

Norton Women's and Children's Hospital, Louisville, Kentucky

Local Institution - 0065, Baltimore, Maryland

Massachusetts General Hospital, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

Mayo Clinic in Rochester, Minnesota, Rochester, Minnesota

Washington University School of Medicine, Saint Louis, Missouri

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Roswell Park Cancer Institute, Buffalo, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

University of North Carolina Medical Center, Chapel Hill, North Carolina

Local Institution - 0067, Charlotte, North Carolina

Oncology Hematology Care, Cincinnati, Ohio

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Oregon Health and Science University, Portland, Oregon

Local Institution - 0070, Philadelphia, Pennsylvania

Tennessee Oncology, Nashville, Tennessee

Local Institution - 0043, Nashville, Tennessee

Local Institution - 0069, Austin, Texas

UT Southwestern Medical Center, Dallas, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

Methodist HealthCare System of San Antonio Clinical Trials Office, Texas Transplant Institute, San Antonio, Texas

LDS Hospital, Salt Lake City, Utah

Virginia Oncology Associates, Norfolk, Virginia

Fred Hutchinson Cancer Center, Seattle, Washington

University Hospital and UW Health Clinics, Madison, Wisconsin

Local Institution - 0077, Camperdown, New South Wales

Local Institution - 0075, Brisbane, Queensland

Local Institution - 0074, Melbourne, Victoria

Local Institution - 0076, Melbourne, Victoria

Tom Baker Cancer Center, Calgary, Alberta

McGill University Health Centre, Montréal, Quebec

Nagoya City University Hospital, Nagoya, Aichi

Hyogo Medical University Hospital, Nishinomiya, Hyogo

Chiba University Hospital, Chiba, Not set

University Hospital,Kyoto Prefectural University of Medicine, Kyoto, Not set

Japanese Red Cross Medical Center, Tokyo, Not set

Conditions: Multiple Myeloma

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HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs

NCT06011551

Recruiting

A multi-center, prospective, dual arm, randomized, controlled pivotal study to evaluate the safety and effectiveness of the ReGelTec HYDRAFIL™ System.

Gender:

ALL

Ages:

Between 22 years and 85 years

Trial Updated:

06/16/2025

Locations: Alabama Clinical Therapeutics, Birmingham, Alabama +8 locations

Conditions: Degenerative Disc Disease (DDD)

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Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

NCT05701358

Recruiting

COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/16/2025

Locations: UCLA, Los Angeles, California +112 locations

UCLA, Los Angeles, California

University of California, San Francisco, San Francisco, California

Cardiovascular Research Institute of Kansas, Wichita, Kansas

The Johns Hopkins University School of Medicine, Baltimore, Maryland

University of Michigan, Ann Arbor, Michigan

Metropolitan Cardiology Consultants / Metropolitan Heart and Vascular Institute (MCC/MHVI), Coon Rapids, Minnesota

RWJ Barnabas Health, Jersey City, New Jersey

Montefiore Medical Center, Bronx, New York

Bassett Medical Center, Cooperstown, New York

VA New York Harbor HealthCare System, New York, New York

NYU Grossman School of Medicine, New York, New York

Cleveland Clinic, Cleveland, Ohio

University of Virginia Medical Center, Charlottesville, Virginia

Westmead Hospital, Westmead, New South Wales

Klinik Floridsdorf, Vienna, Not set

McGill University Health Centre (MUHC), Montréal, Quebec

William Osler Health System, Brampton, Not set

University of Alberta Hospital, Mazankowski Heart, Edmonton, Not set

Hamilton Health Sciences, Hamilton, Not set

Kingston Health Sciences Centre, Kingston, Not set

St. Mary's General Hospital, Kitchener, Not set

London Health Sciences Centre, London, Not set

Centre Hospitalier de l'Universite de Montreal, Montréal, Not set

Hopital du Sacre-Coeur de Montreal, Montréal, Not set

Southlake Regional Health Centre, Newmarket, Not set

Nova Scotia Health, Nova Scotia, Not set

University of Ottawa Heart Institute, Ottawa, Not set

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Not set

Regina General Hospital, Regina, Not set

Royal University Hospital, Saskatoon, Not set

Niagara Health, St. Catharines, Not set

Newfoundland and Labrador Health Services, St. John's, Not set

Thunder Bay Regional Health Sciences Centre, Thunder Bay, Not set

St. Michael's Hospital (Unity Health Toronto), Toronto, Not set

Sunnybrook Health Sciences Centre, Toronto, Not set

Ciusss McQ - Chaur, Trois-Rivières, Not set

St Paul's Hospital, Vancouver, Not set

Vancouver General Hospital, Vancouver, Not set

St. Boniface Hospital, Winnipeg, Not set

St. Anne's University Hospital, Brno, Not set

Aalborg University Hospital, Aalborg, Not set

Aarhus University Hospital, Aarhus, Not set

Rigshospitalet - Copenhagen University Hospital, Copenhagen, Not set

Helsinki University Hospital, Helsinki, Not set

TAYS Sydankeskus Oy, Tampere, Not set

Turku University Hospital, Turku, Not set

St. Vinzenz-Hospital, Cologne, Not set

Helios Amper-Klinikum, Dachau, Not set

Universitatsklinikum Frankfurt, Frankfurt, Not set

Marienkrankenhaus, Hamburg, Not set

Schoen Klink Hamburg, Hamburg, Not set

University Heart & Vascular Center Hamburg, Hamburg, Not set

WKK Heide, Heide, Not set

Gottsegen National Cardiovascular Center, Budapest, Not set

University of Szeged, Szeged, Not set

Lisie Hospital, Ernakulam, Kerala

Meditrina Hospital, Kollam, Kerala

Caritas Hospital Trust, Kottayam, Kerala

Apollo Rajshree Hospitals, Indore, Madhya Pradesh

Rukmani Birla Hospital, Jaipur, Rajasthan

Apollo Hospital, Chennai, Tamil Nadu

The Madras Medical Mission, Chennai, Tamil Nadu

Meenakshi Mission Hospital and Research Center, Madurai, Tamil Nadu

Medicover Hospitals, Hyderabad, Not set

Krishna Institute of Medical Sciences, Secunderabad, Not set

Azienda USL Toscana Sud Est, Arezzo, Not set

UOC Cardiologia - Ospedale Maggiore, Bologna, Not set

Azienda Ospedaliero - Universitaria di Ferrara, Ferrara, Not set

Misericordia Hospital, Grosseto, Not set

Azienda USL-IRCCS di Reggio Emilia, Reggio, Reggio Emilia, Not set

Sant Andrea Hospital - Sapienza University, Rome, Not set

Sorlandet Hospital Arendal, Kristiansand, Arendal

Oslo University Hospital Ulleval, Oslo, Not set

Stavanger University Hospital, Stavanger, Not set

University Hospital Tromso, Tromso, Not set

Provincial Specialized Hospital, Legnica, Dolnoslaskie

Miedziowym Centrum Zdrowia S.A. w Lubinie, Lubin, Dolnoslaskie

Medical University of Warsaw, Warsaw, Mazowieckie

Institute for Cardiovascular Diseases Dedinje, Belgrade, Not set

University Clinical Center of Serbia, Belgrade, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital Ramon y Cajal, Madrid, Not set

Hospital Universitario de La Princesa, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Virgen del Rocio, Seville, Not set

Hospital Universitari i Politecnic La Fe, Valencia, Not set

Hospital Clinico Universitario de Valladolid, Valladolid, Not set

Karolinska University Hospital, Huddinge, Not set

Lanssjukhuset RYHOV, Jonkoping,, Not set

Karlstad Central Hospital, Karlstad, Not set

Skane University Hospital, Lund, Not set

Danderyd Hospital, Stockholm, Not set

Umeå University Hospital, Umeå, Not set

Uppsala University Hospital, Uppsala, Not set

East Kent Hospitals University NHS Foundation Trust, Ashford, Not set

Blackpool Teaching Hospitals, Blackpool, Not set

Ninewells Hospital, Dundee, Not set

Harefield Hospital, Harefield, Not set

Kettering General Hospital, Kettering, Not set

University Hospitals of Leicester, Leicester, Not set

Liverpool Heart and Chest Hospital, Liverpool, Not set

Barts Health NHS Trust, London, Not set

Imperial College Healthcare NHS Trust, London, Not set

Royal Free London NHS Foundation Trust, London, Not set

Manchester University NHS Foundation Trust, Manchester, Not set

The James Cook University Hospital, Middlesbrough, Not set

Freeman Hospital, Newcastle upon Tyne, Not set

Royal Berkshire Foundation NHS Trust, Reading, Not set

Sheffield Teaching Hospitals, Sheffield, Not set

East and North Hertfordshire NHS Trust, Stevenage, Not set

Royal Cornwall Hospitals NHS Trust, Truro, Not set

The Royal Wolverhampton NHS Trust, Wolverhampton, Not set

Worcestershire Acute Hospitals NHS Trust, Worcester, Not set

Conditions: Acute Myocardial Infarction, Coronary Artery Disease

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Immune-Mediated Pathophysiology And Clinical Triage Program

NCT04354649

Recruiting

Many people develop joint pain, stiffness and swelling due to their cancer treatment that targets the immune system. The severity of symptoms ranges from mild to debilitating and sometimes requires delaying or stopping cancer treatment. The usual plan is to discontinue cancer treatment and give relatively high doses of a medication called prednisone (a steroid, which is an anti-inflammatory medication which may suppress the immune system) with a gradual lowering of the dose over several weeks.... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/16/2025

Locations: Cross Cancer Institute, Edmonton, Alberta

Conditions: Arthritis, Arthralgia

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Clinical Study of SNK01 in Participants With Moderate Alzheimer's Disease

NCT06189963

Recruiting

The goal of this clinical trial is to test SNK01 in participants with moderate Alzheimer's Disease. The main questions it aims to answer are: 1. Is SNK01 safe and tolerable when administered every 3 weeks for up to 1 year as an intravenous infusion 2. Can SNK01 administration improve cognitive assessment scores and biomarkers

Gender:

ALL

Ages:

Between 40 years and 85 years

Trial Updated:

06/16/2025

Locations: Behavioral Research Specialists, LLC, Glendale, California +4 locations

Conditions: Moderate Alzheimer Disease

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A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease

NCT06198712

Recruiting

This study is being done to learn about etavopivat, a once a day medicine taken by mouth in adolescents with sickle cell disease. The main goals are to study safety and how long etavopivat stays in the bloodstream, while also studying if there are benefits from taking etavopivat. Eligible participants who enter the study will start a 96-week treatment period. At the end of the 96 weeks, participants will have an end of study visit that occurs 4 weeks later. The participants will receive etavopiv... Read More

Gender:

ALL

Ages:

Between 12 years and 18 years

Trial Updated:

06/16/2025

Locations: The Hospital for Sick Children, Toronto, Ontario +14 locations

Conditions: Sickle Cell Disease

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Circulating Vascular Regenerative Cell Exhaustion in Individuals Without Type 2 Diabetes Who Are of South Asian or European Origins

NCT06769347

Recruiting

ORIGINS-VRCE-2 is an observational study aimed to assess how blood vessel forming stem cells from individuals without diabetes or a history of cardiovascular disease differ between individuals of South Asian and European ethnicities. The overarching objective of the study is to investigate whether differential vessel reparative stem cell populations and characteristics may underlie the elevated cardiovascular risk observed among South Asian individuals compared to individuals of European origins... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/16/2025

Locations: Markham HealthPlex Medical Centre, Markham, Ontario +4 locations

Conditions: Cardiovascular Diseases Risk

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