Fluids in Septic Shock (FISSH)
NCT03677102
Recruiting
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world. Given uncertainty about the impact of lower chloride versus higher chloride solutions on mortality, it is unlikely that clinical practice will change without new and direct randomized controlled trial (RCT) evidence. Editorials published in leading critical care journals have called for RCT's to address this important cli... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
06/03/2025
Locations: University of Calgary - Foothills Medical Centre, Calgary, Alberta +28 locations
Conditions: Sepsis, Septic Shock
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Inspiratory Work of Breathing Before and After Extubation
NCT07017608
Recruiting
Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator). When the patient is ready to be liberated from the mechanical ventilator because the initial insult for intubation has been resolved, the patient is screened using the readiness to wean test in preparation for extubation. As the patient passes this screening, a spontaneous... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: Toronto General Hospital, University Health Network, Toronto, Ontario
Conditions: Lung Transplant; Complications, Ventilator-Induced Lung Injury, Ventilator Associated Pneumonia
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Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
NCT06592924
Recruiting
This study is being done to answer the following question: can the chance of prostate cancer growing or spreading be lowered by adding a drug to the usual combination of drugs? This study would like to find out if this approach is better or worse than the usual approach for prostate cancer. The usual approach for patients who are not in a study is hormone treatment with Androgen Deprivation Therapy (ADT) and Androgen-Receptor Pathway Inhibitor (ARPI).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Ottawa Hospital Research Institute, Ottawa, Ontario
Conditions: Prostate Cancer (Adenocarcinoma)
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TIRCON International NBIA Registry
NCT05522374
Recruiting
TIRCON-reg aims to * continue the provision of a global registry and natural history study for NBIA disorders * harmonize and cover existing national and single site registries * enable participation of countries and single sites that so far have no access to an NBIA registry * join forces in order to recruit sufficient numbers of patients * define the natural history of NBIA disorders * define the most appropriate outcome measures * inform the design and facilitate the conduction of clinical t... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/02/2025
Locations: Children's Hospital of Eastern Ontario, Division of Neurology, Department of Pediatrics, Ottawa, Not set +8 locations
Conditions: Neurodegeneration With Brain Iron Accumulation (NBIA), Pantothenate Kinase-associated Neurodegeneration (PKAN), Beta-Propeller Protein-Associated Neurodegeneration (BPAN), Mitochondrial Membrane Protein Associated Neurodegeneration (MPAN), Fatty Acid Hydroxylase-associated Neurodegeneration (FAHN), Kufor Rakeb Syndrome, Neuroferritinopathy, Aceruloplasminemia, Woodhouse Sakati Syndrome, COASY Protein-associated Neurodegeneration (CoPAN), PLA2G6-Associated Neurodegeneration (PLAN)
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An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
NCT05876754
Recruiting
A Phase 3b research study to consolidate the data that ivosidenib is safe and effective in adult patients with previously treated, locally advanced, or metastatic cholangiocarcinoma (CCA). All patients who meet inclusion criteria will be enrolled to receive ivosidenib tablets orally once daily for 28 day cycles, continuing as long as clinical benefit and consent for participation is maintained. There will be a minimum of 6 study visits from screening until the final follow-up, if one cycle of tr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Erebouni MC, Yerevan, Not set +77 locations
Conditions: Cholangiocarcinoma
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Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study
NCT05290129
Recruiting
This study is designed to determine the minimal effective oxytocin maintenance infusion required in labouring women undergoing cesarean delivery to achieve the best effect. Oxytocin is a drug that is routinely used to help the uterus to contract and keep it contracted after delivery. Consequently, it will help to reduce blood loss after delivery. In order to determine the minimal effective dose, the investigators will conduct a dose-finding study. The first patient will receive a set oxytocin in... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
06/02/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Postpartum Hemorrhage
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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
NCT05219110
Recruiting
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E. coli (STEC) infection in children and adolescents when compared with traditional approaches (conservative fluid management).
Gender:
ALL
Ages:
Between 9 months and 21 years
Trial Updated:
06/02/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +25 locations
Conditions: Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
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Evaluating the Impact of the Eating Matters Program on the Nutritional Status of Medical Rehab Patients at Joseph Brant Hospital
NCT04445883
Recruiting
This research study will determine the impact of the Eating Matters Program on the nutritional status of elderly patients at Joseph Brant Hospital. The Eating Matters Program at Joseph Brant Hospital is a volunteer-based feeding assistance program that aims to improve patients' nutritional intake by providing assistance during mealtimes. As research on the impact of such programs on food intake is limited in Canada, this study will explore how the Eating Matters Program influences protein and en... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
05/30/2025
Locations: Joseph Brant Hospital, Burlington, Ontario
Conditions: Food Intake
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International Care Bundle Evaluation in Cerebral Hemorrhage Research
NCT06429332
Recruiting
Spontaneous intracerebral haemorrhage (ICH) accounts for approximately 10-15% of all strokes but stands for 50% of stroke-related morbidity and mortality. Approximately half of all patients with ICH have a decreased level of consciousness at hospital admission. Despite this, intensive care and neurosurgical interventions are uncommon. A study conducted in low- and middle-income countries has demonstrated a beneficial effect of a treatment package consisting of early intensive blood pressure lowe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2025
Locations: The George Institute for Global Health, Sydney, Not set +13 locations
Conditions: Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke, Cerebrovascular Disease
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Study on the Effects of Resistant Potato Starch on Gut Bacteria in Healthy Adults
NCT06949631
Recruiting
The goal of this clinical trial is to evaluate how taking Resistant Potato Starch affects the gut microbiota compared to a placebo, in healthy adults. Over a 4-week period, participants will provide stool samples for analysis to detect any changes in gut bacteria. They will also record daily information in a diary about their stool consistency, frequency, digestive symptoms, and overall quality of life.
Gender:
ALL
Ages:
Between 18 years and 69 years
Trial Updated:
05/30/2025
Locations: Apex Trials, Guelph, Ontario/ON
Conditions: Gastrointestinal Microbiota
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Learning Study: Improving Vision in Adults With Macular Degeneration
NCT04762368
Recruiting
The purpose of this study is to test whether a kind of brain stimulation called anodal transcranial direct current stimulation (a-tDCS) can be combined with perceptual learning to improve the ability of people with age-related macular degeneration (AMD) or juvenile macular degeneration (JMD) to read words presented to them on a computer screen better than if perceptual learning alone were used. In addition, secondary measures of visual acuity will also be examined to determine whether brain sti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2025
Locations: University of Waterloo, Waterloo, Ontario +1 locations
Conditions: Macular Degeneration
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NIF-Guided RAMIE Using ICG Versus OTE Feasibility RCT
NCT04938973
Recruiting
In Canada, the incidence of esophageal cancer has been increasing over time, while surgical standards for esophageal resections have remained unchanged. Currently, the standard of surgical care for this cancer is Open Transthoracic Esophagectomy (OTE), a highly morbid operation that is associated with a complication rate of 60-80%, and a recovery period of many months. While Minimally Invasive Esophagectomy (MIE) has been developed it has not been adopted because it is highly complex, technicall... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2025
Locations: St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Conditions: Esophageal Cancer
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