Nature-based Intervention for Chronic Pain in Older People
NCT07002853
Recruiting
The goal of this clinical trial is to learn if a nature-based intervention program has positive effects on the physical and psychosocial health in a group of older participants with chronic non-specific lower back pain. The main questions it aims to answer are: Will the program improve: * The physical outcomes such as mobility, strength and balance? * The psychosocial health outcomes? Participants will: * Be assessed before and after the program; * Participate in one session per week of the... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
05/24/2025
Locations: Université du Québec à Chicoutimi, Saguenay, Quebec
Conditions: Chronic Disease, Chronic Pain (Back / Neck), Older Adults (65 Years and Older)
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OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
NCT06016738
Recruiting
This phase 3 clinical trial compares the safety and efficacy of palazestrant (OP-1250) to the standard-of-care options of fulvestrant or an aromatase inhibitor in women and men with breast cancer whose disease has advanced on one endocrine therapy in combination with a CDK4/6 inhibitor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Clinical Trial Site, Tucson, Arizona +173 locations
Conditions: Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer, HER2 Negative Breast Carcinoma
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Organ Preservation in Rectal AdenoCa Using Hypofractionated Pelvic RT(Hypo-OPRA)
NCT06991465
Recruiting
The combination of preoperative pelvic RT - either long-course chemoradiotherapy (LCCRT) or short-course radiotherapy (SCRT)- followed by surgery has been the standard of care in the curative treatment of locally advanced adenocarcinoma of the rectum for decades. Some patients however achieve a complete clinical response (cCR) to their preoperative treatment which opens the possibility of avoiding surgery and consequently preserving the rectum. There now exists a growing body of data from centre... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/23/2025
Locations: McGill University Health Centre, Montreal, Quebec
Conditions: Colorectal Carcinoma
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Threonine Requirement in Adult Males With Crohn's Disease Using IAAO
NCT04740541
Recruiting
The goal of the current study is to measure the requirement for threonine in patients with CD using the IAAO method and compare the requirement to previously determined threonine requirement estimated in young adults using the IAAO technique. It is hypothesize that the requirement for threonine in patients with CD will be higher than the threonine requirement previously determined in young adults using the IAAO method. Up to 10 clinically stable patients with CD will be recruited from the IBD Cl... Read More
Gender:
MALE
Ages:
Between 18 years and 49 years
Trial Updated:
05/23/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Crohn Disease, IBD
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The Tryptophan Requirement in Healthy Adults
NCT06283706
Recruiting
The aging population is growing rapidly. For the first time ever, Canadian seniors outnumbered young adults in 2016. Aging is associated with many physical and metabolic deteriorations including the loss of muscle mass and strength, insulin resistance, increased inflammation and oxidative stress. The muscles of our bodies are composed of proteins and proteins are made of small building blocks called amino acids. Our bodies have the ability to make some amino acids which are called the non-essen... Read More
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
05/23/2025
Locations: Hospital for Sick Children, Toronto, Ontario
Conditions: Healthy Aging
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Threonine Requirement in Adults >60 Years of Age
NCT06225648
Recruiting
Threonine is an essential amino acid and must be obtained from the diet. The body's capacity to maintain adequate mucin synthesis is directly related to the bioavailability of certain amino acids, including threonine, serine and proline (1). Moreover, the rate of mucin synthesis has been demonstrated to be directly related to the availability of dietary threonine in healthy rats (2) and piglets (3,4). Intestinal inflammation is known to increase gastrointestinal threonine uptake and mucin synthe... Read More
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
05/23/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Healthy, Aging
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Evidence-based Internet Cognitive-behavioral Therapy for Social Anxiety
NCT06403995
Recruiting
The objectives of the study are to 1) to translate and adapt iCBT Shyness Program to the Canadian context; 2) to examine the completion and effectiveness of the Canadian adapted, including the French translated and English iCBT Shyness Program, in improving SAD symptoms; 3) to explore barriers and facilitating factors to the program's implementation. The overall study design is a hybrid effectiveness-implementation study of a quasi-experimental parallel group trial reflecting real world pathways... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: CISSS de la Montérégie-Centre, Greenfield Park, Quebec +1 locations
Conditions: Social Anxiety
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Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism
NCT04263038
Recruiting
The clinical significance of pulmonary embolism (PE) limited to the subsegmental pulmonary arteries, so called isolated subsegmental pulmonary embolism (SSPE), remains controversial. Whether isolated SSPE represents "true" PE, a clinically more benign form of PE, a physiologic lung clearing process, or a false positive result (artifact) is currently unclear and hence, whether patients with isolated SSPE benefit from anticoagulant treatment is uncertain. Despite growing evidence from observationa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Centre hospitalier universitaire de Liege, Liège, Not set +38 locations
Conditions: Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases, Cardiovascular Diseases, Respiratory Tract Diseases, Venous Thromboembolism, Anticoagulant-induced Bleeding, Bleeding
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A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis
NCT06454188
Recruiting
A Randomized, Placebo-controlled, Multicenter, Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients with Active Psoriatic Arthritis (UP-SPOUT)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Oregon Health and Science University, Portland, Oregon +3 locations
Conditions: Psoriatic Arthritis, Spondyloarthritis, Axial
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Tryptophan Metabolism in Healthy Young Adults
NCT06551545
Recruiting
Tryptophan is an essential amino acid needed for growth and bodily functions. It is used to make serotonin which is needed for the brain to develop and function properly. However, when the body is stressed, tryptophan is broken down into compounds that can cause harm to the brain. Premature babies who get nutrition through their vein \[i.e. total parenteral nutrition (TPN)\] can experience this type of stress. The amount of tryptophan in TPN solutions is much higher than what premature babies ne... Read More
Gender:
MALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/23/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Healthy
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Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients
NCT05425355
Recruiting
The INTACT-HIP trial study will evaluate feasibility of conducting a randomized, double-blinded controlled trial comparing postoperative treatment with intravenous (IV) acetaminophen versus oral acetaminophen, in older adults undergoing hip fracture surgery. The results of this feasibility trial will be used to inform designing a larger, multi-center, randomized controlled trial to assess the efficacy of IV acetaminophen compared to oral acetaminophen to reduce delirium and improve other clinic... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
05/23/2025
Locations: Toronto Western Hospital (UHN), Toronto, Ontario
Conditions: Hip-fracture, Surgery
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Phenylalanine, Methionine and Histidine Requirements in TPN Fed Neonates
NCT05562310
Recruiting
This is a single center project assessing the requirements for three essential amino acids in TPN fed neonates. Using the Carbon Oxidation method (indicator amino oxidation and direct amino acid oxidation method), the investigators will determine the requirement of each of the 3 amino acids. The investigators will first determine the requirement for Phenylalanine, then Methionine and finally Histidine. The investigators will recruit 18 - 20 babies per amino acid study. Breath and urine samples w... Read More
Gender:
ALL
Ages:
Between 1 day and 28 days
Trial Updated:
05/23/2025
Locations: Glenda Courtney-Martin, Toronto, Ontario
Conditions: Stable Neonates, Receiving Total Parenteral Nutrition (TPN)
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