The Tryptophan Requirement in Healthy Adults
NCT06283706
Recruiting
The aging population is growing rapidly. For the first time ever, Canadian seniors outnumbered young adults in 2016. Aging is associated with many physical and metabolic deteriorations including the loss of muscle mass and strength, insulin resistance, increased inflammation and oxidative stress. The muscles of our bodies are composed of proteins and proteins are made of small building blocks called amino acids. Our bodies have the ability to make some amino acids which are called the non-essen... Read More
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
05/23/2025
Locations: Hospital for Sick Children, Toronto, Ontario
Conditions: Healthy Aging
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Clinical Evaluation of Reverse Versus Anatomic Shoulder Arthroplasty Techniques in the Treatment of Osteoarthritis
NCT05395819
Recruiting
Osteoarthritis (OA) is the most common form of arthritis, affecting millions of people worldwide and it is common in an aging population. Surgical shoulder replacement (arthroplasty) is typically considered when non-surgical measures, such as physiotherapy or medication, have failed. There are two commonly performed surgical replacement procedures in patients who have advanced shoulder OA, and are 65 years of age and older: "Total Shoulder replacement or Arthroplasty (TSA)" and "Reverse Total Sh... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
05/23/2025
Locations: Royal Alexandra Hospital (Orthopaedic Surgical Centre), Edmonton, Alberta +7 locations
Conditions: Shoulder Osteoarthritis
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Threonine Requirement in Adult Males With Crohn's Disease Using IAAO
NCT04740541
Recruiting
The goal of the current study is to measure the requirement for threonine in patients with CD using the IAAO method and compare the requirement to previously determined threonine requirement estimated in young adults using the IAAO technique. It is hypothesize that the requirement for threonine in patients with CD will be higher than the threonine requirement previously determined in young adults using the IAAO method. Up to 10 clinically stable patients with CD will be recruited from the IBD Cl... Read More
Gender:
MALE
Ages:
Between 18 years and 49 years
Trial Updated:
05/23/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Crohn Disease, IBD
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OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
NCT06016738
Recruiting
This phase 3 clinical trial compares the safety and efficacy of palazestrant (OP-1250) to the standard-of-care options of fulvestrant or an aromatase inhibitor in women and men with breast cancer whose disease has advanced on one endocrine therapy in combination with a CDK4/6 inhibitor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Clinical Trial Site, Tucson, Arizona +173 locations
Conditions: Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer, HER2 Negative Breast Carcinoma
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Predicting Acute Exacerbations of COPD Using Wearable Devices and Remote Monitoring Technology With AI/ML Models
NCT06802003
Recruiting
This study is aimed to collect real-time physiological data using two wearable devices (a biometric ring and a biometric wristband), daily lung mechanical measurements by a handheld oscillometer, and participant-reported symptoms in patients with COPD remotely from their home environment. The data will be used to train and validate artificial intelligence and machine learning (AI/ML) models to predict COPD exacerbations in advance of their actual occurrence. The data will also be used to test th... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
05/22/2025
Locations: McGill University Health Centre, Montreal, Quebec
Conditions: COPD, AE COPD
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CRICKET: Critical Events in Anaesthetised Kids Undergoing Tracheal Intubation
NCT05804188
Recruiting
The investigators' overall objective is to assess the incidence of critical events related to tracheal intubation at all international study sites. Furthermore, the study will investigate the used intubation techniques and identify possible improvement measures to increase patient safety.
Gender:
ALL
Ages:
16 years and below
Trial Updated:
05/22/2025
Locations: Department of Anesthesiology, Critical Care and Pain Medicine, Boston, Massachusetts +7 locations
Conditions: Intubation Complication, Adverse Events
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Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial
NCT05337033
Recruiting
Chronic headaches are a major cause of disability among adolescents. Cannabis products have supported the management of headaches in adults and may play a role in pediatric chronic pain. We propose a multisite, open-label, tolerability study conducted across three centers in Canada of Cannabidiol-enriched Cannabis Herbal Extract in adolescents (ages 14 to 17 years old) with chronic headaches. The study includes a one month baseline assessment, four months of escalating treatment doses and a wean... Read More
Gender:
ALL
Ages:
Between 14 years and 17 years
Trial Updated:
05/22/2025
Locations: University of British Columbia, Vancouver, British Columbia +2 locations
Conditions: Chronic Migraine
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Safety and Efficacy of Tideglusib in Congenital or Childhood Onset Myotonic Dystrophy
NCT05004129
Recruiting
This is an open-label phase 2/3 study for individuals with Congenital Myotonic Dystrophy (Congenital DM1) who participated in the preceding AMO-02-MD-2-003 study or individuals with either Congenital or Childhood Onset DM1 who are treatment naïve.
Gender:
ALL
Ages:
Between 6 years and 45 years
Trial Updated:
05/22/2025
Locations: Arkansas Children's Hospital, Little Rock, Arkansas +13 locations
Conditions: Congenital Myotonic Dystrophy
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Concordance of Molecular Classification Based on Fine Needle Biopsy (FNB) and Surgical Samples
NCT06133374
Recruiting
The purpose of this study is to determine whether results from a fine needle biopsy are the same as results from a larger sample that is acquired from the surgical pathology using the Thyroid GuidePx® test in patients with papillary thyroid carcinoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Foothills Medical Centre, Calgary, Alberta
Conditions: Papillary Thyroid Cancer
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Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
NCT01790152
Recruiting
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment.
Gender:
ALL
Ages:
All
Trial Updated:
05/22/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +78 locations
Conditions: Hodgkin Lymphoma in Remission, Leukemia in Remission, Lymphoblastic Lymphoma, Osteosarcoma, Recurrent Leukemia, Recurrent Lymphoma, Recurrent Malignant Neoplasm
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Evaluation of MRI-conditional 12-lead ECG
NCT04247685
Recruiting
With MRI's increasing role in detecting central nervous system and orthopedic diseases, patients with ischemic history are increasingly referred for MRI exams. Currently, 3-lead ECG gating systems are utilized during cardiac MRI scanning as standard of care. However, this monitoring system is often insufficient to evaluate for the development of important arrhythmias or ischemia during MRI scanning. Morevoer, MRI associated magnetic fields and radio frequency pulses can produce interference in t... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/22/2025
Locations: Sunnybrook Health Sciences Center, Toronto, Ontario
Conditions: Atrial Fibrillation
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Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid
NCT06997796
Recruiting
Nosebleeds are very common, occurring in 60% of the population; in some patients, nosebleeds are a life-threatening emergency. To stop a nosebleed in the emergency department, doctors usually have to burn the nose (called cauterization) or insert pledgets (called nasal packing) into the nose to apply direct pressure to the bleeding site. Nasal packing can cause pain and discomfort at the time it is inserted in the nose and again when it is removed. In rare cases it can cause a range of complicat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Peterborough Regional Health Centre, Peterborough, Ontario
Conditions: Epistaxis Nosebleed
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