The ACCESSIT Study
NCT05207046
Recruiting
The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
05/15/2025
Locations: Unity Health Toronto - St. Michael's Hospital, Toronto, Ontario
Conditions: Respiratory Support
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PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
NCT06716463
Recruiting
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal cannula (HFNC) or non-invasive ventilation (NIV). The main question, it aims to answer is: Does abnormal regional ventilation could predict HFNC or NIV failure?
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: St. Michael's Hospital, Toronto, Ontario
Conditions: Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
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The Use of Immersive 360-degree Video in Improving Spatial Orientation
NCT05894005
Recruiting
As medical students rotate through different hospital sites as part of their studies, the students are frequently exposed to new and unfamiliar environments. This can cause anxiety in some students, and can potentially result in students becoming lost, and arriving late to their activities. To prevent this, students are currently provided with instructions in the form of written directions, photographs, maps, and/or 2-dimensional videos. In this study, the investigators will test if immersive 3... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/14/2025
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Virtual Reality
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BPH Global Registry
NCT05543200
Recruiting
Benign prostatic hyperplasia (BPH) is one of the most common performed surgical procedures in urology. Over the past few decades there have been an increasing development of newer surgical treatment options. Additionally, the outcome parameters for BPH treatments have been standardized. While data are available for the initial pivotal studies, post-market release data are lacking. Under the umbrella of uCARE, we have started a prospective, ongoing international registry for recording demographic... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Keck Medicine of USC, Los Angeles, California +22 locations
Conditions: Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
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RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy
NCT03118986
Recruiting
Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents. Most children receiving highly emetogenic chemotherapy (HEC), including those receiving hematopoietic stem cell transplant (HSCT) conditioning, experience CIV despite receiving antiemetic prophylaxis. Olanzapine improves CINV control in adult cancer patients, has a track record of safe use in children with psychiatric illness, does not interact w... Read More
Gender:
ALL
Ages:
Between 30 months and 18 years
Trial Updated:
05/14/2025
Locations: University of California, San Francisco, California +9 locations
Conditions: Vomiting in Infants and/or Children, Nausea, Hematopoietic System--Cancer, Oncology
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Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer
NCT04178174
Recruiting
This is a randomized clinical trial comparing the outcomes of short-course chemoradiation consisting in stereotactic boost to the gross tumor and de-esclalated chemoradiation to the elective neck in human papilloma associated oropharynx cancer vs. the current standard 7-week course chemoradiation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: London Health Sciences Center, London, Ontario +1 locations
Conditions: Head and Neck Cancer, Oropharynx Cancer, Human Papilloma Virus
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Pulmonary Embolism International THrOmbolysis Study-3
NCT04430569
Recruiting
In this study, we will assess the efficacy and safety of a reduced dose of thrombolytic therapy given in addition to low-molecular-weight heparin in patients with intermediate-high-risk acute pulmonary embolism. Half of participants will receive thrombolytic treatment, while the other half will receive a placebo.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Graz, Mediz Universität, Graz, Not set +97 locations
Conditions: Pulmonary Embolism
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Increasing Family Engagement in Critical Care
NCT06586528
Recruiting
The primary aim of this trial is to evaluate if the NGAGE tool improves care engagement in family members of ICU patients. The secondary objectives are to assess if the NGAGE tool improves communication, care satisfaction, psychological symptoms, and quality of life in family members of ICU patients. The NGAGE trial is a stepped wedge cluster randomized trial of 6 Canadian adult ICUs, involving 194 family members. A family member will be considered anyone with a biological, emotional, or legal... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: McGill University Health Centre, Montreal, Quebec +1 locations
Conditions: Family Engagement, Critical Care, Intensive Care, Patient and Family Engagement, Health Care Delivery, Family-centered Care
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ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
NCT04335994
Recruiting
Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in these conditions. OSA is typically treated with continuous positive airway pressure (CPAP), which has been shown to improve cognition in VCI and slow cognitive decline in AD. Despite the need to identify OSA in patients with VCI/AD, these patients often do not undergo test... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/14/2025
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Obstructive Sleep Apnea, Alzheimer Disease, Vascular Dementia, Mild Cognitive Impairment, Parkinsons Disease With Dementia, Dementia With Lewy Bodies, Mixed Dementia
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An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
NCT06480552
Recruiting
The primary objectives of this trial are to: * Characterize the safety and tolerability of TEV-56278 * Determine the Recommended Phase 2 Dose (RP2D) * Evaluate antitumor activity of TEV-56278 * Determine the safety and tolerability of TEV-56278 in combination with pembrolizumab * Determine a RP2D of TEV-56278 in combination with pembrolizumab The secondary objectives of this trial are to: * Characterize the serum pharmacokinetics of TEV-56278 * Evaluate the antitumor activity of TEV-56278 * D... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Teva Investigational Site 12017, Los Angeles, California +9 locations
Conditions: Advanced Solid Tumors
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Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases
NCT03775330
Recruiting
This clinical study is a parallel, prospective observational single-centre trial in patients presenting with 5 to 30 brain metastases. Patients to receive either stereotactic radiosurgery (SRS) alone or SRS plus whole brain radiation (WBRT) will be enrolled.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Sunnybrook Odette Cancer Centre, Toronto, Ontario
Conditions: Brain Metastases
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The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma
NCT06850766
Recruiting
The body's biological functions follow a circadian rhythm, meaning that individual biological functions in the body change over a 24-hour cycle. There is evidence suggesting that the body and cancer cells may react differently to anti-cancer treatment based on the time of day they are exposed. In fact, researchers have already found that giving anti-cancer treatments at a particular time of the day works better in rectal and ovarian cancer. Temozolomide (TMZ) is a chemotherapy pill/capsule commo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: London Health Sciences Centre, London, Ontario +1 locations
Conditions: IDH-Wildtype Glioblastoma, Glioblastoma (GBM)
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