Early Diagnosis and Treatment of Undiagnosed Asthma or COPD: THE UCAP 2 TRIAL
NCT06392776
Recruiting
Our research group has found that Canadians with undiagnosed asthma or chronic obstructive pulmonary disease (COPD) have increased respiratory symptoms and worse health-related quality of life. The investigators recently developed and validated an on-line questionnaire to accurately identify these symptomatic, undiagnosed individuals. The investigators will advertise in the community asking individuals to complete the on-line questionnaire at home, at their leisure, to determine if they are at... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: St. Joseph's Hamilton Healthcare, Hamilton, Ontario +3 locations
Conditions: COPD, Asthma
Register for Updates
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
NCT03033251
Recruiting
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide. The disease is marked by multiples episode of worsening, termed exacerbations necessitating frequent hospitalizations. During these exacerbations, patients present breathless, and in the most severe cases, are admitted to an Intensive Care Unit (ICU) for respiratory assistance. Currently, respiratory assistance is provided b... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
05/15/2025
Locations: St. Michael's Hospital, Toronto, Ontario
Conditions: Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
Register for Updates
Assessment of a Novel Sound-based Treatment for Managing Distress Related to Tinnitus
NCT06083519
Recruiting
The goal of this clinical trial is to assess the effectiveness of a sound-based passive treatment for reducing stress and annoyance induced by tinnitus, and how this therapy may improve tinnitus sufferers' quality of life. The main questions it aims to answer are: • \[question 1: to assess the efficacy of the LUCID/VIBE in managing the tinnitus handicap (measured by the reducing of the annoyance/stress response to tinnitus) contributing to the improvement of the quality of life of people living... Read More
Gender:
ALL
Ages:
Between 50 years and 79 years
Trial Updated:
05/15/2025
Locations: Toronto Metropolitan University, Toronto, Ontario
Conditions: Tinnitus
Register for Updates
Perceptual Abnormalities and Their Malleability in BDD
NCT04373629
Recruiting
A core symptom of body dysmorphic disorder (BDD) is perceptual distortions for appearance, which contributes to poor insight and delusionality, limits engagement in treatment, and puts individuals at risk for relapse. Results from this study will provide a comprehensive mechanistic model of brain, behavioral, and emotional contributors to abnormal perceptual processing, as well as how malleable it is with visual modulation techniques. This will lay the groundwork for next-step translational perc... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
05/15/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Body Dysmorphic Disorder
Register for Updates
RecruitmEnt Assessed by eleCtRical Impedance Tomography
NCT04460859
Recruiting
The RECRUIT study is a multinational, multicenter physiological observational study conducted by the PLUG working group. It is a single-day study (1.5-2 hours) associated with specific lung (de)recruitment maneuvers to verify the feasibility of measuring the potential for lung recruitment in mechanically ventilated patients with ARDS by electrical impedance tomography (EIT).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Faculdade de Medicina da University São Paulo, São Paulo, Not set +3 locations
Conditions: Acute Respiratory Distress Syndrome (ARDS)
Register for Updates
A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis
NCT06311682
Recruiting
The purpose of this trial is to test whether treatment with tralokinumab (administered subcutaneous injections \[SC\]) in combination with topical corticosteroids (TCS) is safe and effective to treat moderate-to-severe atopic dermatitis (AD) in children and infants. This will be judged by a range of assessments that rate the severity and extent of atopic dermatitis and its symptoms, as well as general health status and quality of life. The trial will last for up to 4 years. There will be visits... Read More
Gender:
ALL
Ages:
Between 6 months and 11 years
Trial Updated:
05/15/2025
Locations: Leo Pharma Investigational site, Birmingham, Alabama +62 locations
Conditions: Atopic Dermatitis
Register for Updates
The Simplify Project
NCT05011877
Recruiting
The high frequency of unplanned hospital visits of patients with chronic hypercapnic respiratory failure (e.g., chronic obstructive pulmonary disease, obesity-related hypoventilation) constitutes a major public health problem. Most patients admitted for acute exacerbations (AHRF) have additional comorbidities, especially sleep disorders. Often untreated, sleep disorders contribute to multiple readmissions (≈70% at one year) and increase readmission costs. The investigators will: 1) identify thes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: St. Michael's Hospital, Toronto, Ontario
Conditions: Acute Hypercapnic Respiratory Failure
Register for Updates
A Phase 1/2/3 Study of UX701 Gene Therapy in Adults With Wilson Disease
NCT04884815
Recruiting
The primary objectives of this study are to evaluate the safety of single IV doses of UX701 in patients with Wilson disease, to select the UX701 dose with the best benefit/risk profile based on the totality of safety and efficacy data and to evaluate the effect of UX701 on copper regulation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: University of California Los Angeles, Los Angeles, California +16 locations
Conditions: Wilson Disease
Register for Updates
The ACCESSIT Study
NCT05207046
Recruiting
The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
05/15/2025
Locations: Unity Health Toronto - St. Michael's Hospital, Toronto, Ontario
Conditions: Respiratory Support
Register for Updates
Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation
NCT06494085
Recruiting
Pressure support ventilation (PSV) is used to assist the breathing of the intubated patient with some pressure from the ventilator. This support aims at avoiding excessive inspiratory effort, while ensuring a certain degree of training of the patient's inspiratory muscle. Avoiding both minimal and excessive assistance is thus important for the optimal care of the intubated patient ensuring a lung and diaphragm protective ventilation with the goal to liberate the patient from the ventilator as so... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: St. Michael's Hospital, Toronto, Ontario
Conditions: Acute Hypoxemic Respiratory Failure
Register for Updates
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
NCT04251052
Recruiting
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk... Read More
Gender:
FEMALE
Ages:
Between 35 years and 50 years
Trial Updated:
05/15/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +508 locations
Conditions: Ovarian Carcinoma
Register for Updates
Multicenter Clinical Trial of ST-02 for Ablation of Upper Tract Urothelial Carcinoma
NCT06124976
Recruiting
The goal of this prospective clinical trial is to investigate the safety and efficacy of ST-02 (mucoadhesive gemcitabine suspension for pyelocaliceal instillation) to treat Upper Tract Urothelial Carcinoma (UTUC) in participants who have a low-grade tumor. The main questions this study aims to answer are: 1. Can ST-02 effectively eradicate UTUC by 3 months? 2. Is ST-02 safe for patients with UTUC? Participants in this study will receive ST-02, a new formulation with gemcitabine once weekly fo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Vancouver Prostate Centre, Vancouver, British Columbia +2 locations
Conditions: Urothelial Carcinoma of the Renal Pelvis and Ureter, Transitional Cell Cancer of the Renal Pelvis and Ureter
Register for Updates