Clinical Trials & Research Studies in Canada(Updated 8/25)

Domain-specific Aerobic Exercise Training in Coronary Artery Disease

NCT06143332

Recruiting

Exercise training in cardiac rehabilitation (rehab) is a key part of managing a patient with heart disease. It has been shown that cardiac patients who increase their aerobic ("cardio") fitness by exercise training live longer, have better quality of life, and stay out of hospitals more than patients who do not improve their aerobic fitness. The more a patient improves their aerobic fitness the greater the benefit. But it has been shown that more than half of patients do not improve their aerobi... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/08/2025

Locations: The University of Western Ontario, London, Ontario

Conditions: Coronary Artery Disease

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Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)

NCT04474223

Recruiting

Fetal complete (i.e., third degree, 3°) atrioventricular block (AVB), identified in the 2nd trimester of pregnancy in an otherwise normally developing heart, is almost universally associated with maternal anti-Ro autoantibodies and results in death in a fifth of cases. To date treatment of 3° AVB has been ineffective in restoring normal rhythm (NR) which may be because current surveillance is limited to once- weekly fetal echocardiograms. It is hypothesized that there may be a vital transition p... Read More

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

04/08/2025

Locations: Phoenix Children's Hospital/Dignity Health, Phoenix, Arizona +23 locations

Phoenix Children's Hospital/Dignity Health, Phoenix, Arizona

University of California - Los Angeles (UCLA), Los Angeles, California

Stanford University, Palo Alto, California

University of California-San Francisco, San Francisco, California

University of Colorado, Denver (UCD), Aurora, Colorado

Yale University School of Medicine, New Haven, Connecticut

Children's National Medical Center/George Washington University, Washington, District of Columbia

University of Kentucky / Kentucky Children's Hospital, Lexington, Kentucky

University of Louisville / Norton Children's Hospital, Louisville, Kentucky

University of Michigan / C. S. Mott Children's Hospital, Ann Arbor, Michigan

Children's Hospital of Minnesota, Minneapolis, Minnesota

Perinatal Associates of New Mexico, Rio Rancho, New Mexico

NYU Langone Health, New York, New York

Mount Sinai, New York, New York

Columbia University Medical Center, New York, New York

UH Rainbow Babies / Children's Hospital, Cleveland, Ohio

Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio

Vanderbilt University Medical Center, Nashville, Tennessee

Baylor College of Medicine, Houston, Texas

University of Utah Health, Salt Lake City, Utah

University of Vermont Children's Hospital, Burlington, Vermont

Eastern Virginia Medical School (EVMS), Norfolk, Virginia

Seattle Children's Hospital, Seattle, Washington

Stollery Children's Hospital, Edmonton, Alberta

Conditions: AVB - Atrioventricular Block, Fetal AVB

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Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer

NCT06641791

Recruiting

This study is being done to answer the following question: Does stereotactic body radiation therapy (SBRT) provide better cancer control compared to standard radiation therapy (RT) for those with advanced head and neck cancer?

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/08/2025

Locations: Odette Cancer Centre, Toronto, Ontario

Conditions: Advanced Head and Neck Cancer

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Understanding and Treating Suicidal Ideation With Ketamine

NCT06891300

Recruiting

The goal of this clinical trial is to treat active suicidal ideation in individuals with Major Depressive Disorder (MDD) using ketamine and to understand suicidal ideation by examining biological mechanisms using magnetic resonance imaging (MRI), and psychological mechanisms through validated clinical scales and qualitative interviews. The main questions it aims to answer are: 1. Will ketamine will reduce suicidal ideation in a significant proportion of study participants? 2. Will reduction in... Read More

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

04/08/2025

Locations: Royal Ottawa Mental Health Centre, Ottawa, Ontario

Conditions: Suicidal Ideation, Major Depressive Disorder (MDD)

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Contingency Management as an Adjunct Treatment for Rural and Remote Disordered Gamblers

NCT02953899

Recruiting

The purpose of this project is to pilot contingency management as an adjunct treatment to counselling as usual using internet delivered video-conferencing applications for remote disordered gamblers. This project further investigates the impact of adding contingency management to counselling to improve counselling attendance and retention and uses internet-delivered approaches to assist rural and remote disordered gamblers gain access to counselling treatments.

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

04/08/2025

Locations: University of Lethbridge, Lethbridge, Alberta

Conditions: Gambling Disorder

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Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infectious Syphilis

NCT06927843

Recruiting

The goal of this observational study is to evaluate the sensitivity, specificity, and utility of the DPP® Syphilis Screen \& Confirm antibody point-of-care test (POCT) to diagnose infectious syphilis in participants attending the Nine Circles Community Health Centre in Winnipeg, Manitoba. The main questions are: Does the POCT provide accurate results compared to conventional syphilis serology methods? and Can the use of POCT improve the timeline for diagnosis and treatment of syphilis? Researc... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/07/2025

Locations: Nine Circles Community Health Centre, Winnipeg, Manitoba

Conditions: Syphilis

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GLA:D Back Canada - a Program for Chronic and Persistent Low Back Pain

NCT06924671

Recruiting

GLA:D Back is a program developed in Denmark to help people with persistent low back pain. This study will assist in contextualizing Danish content into an English version of the program.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/05/2025

Locations: University of Alberta, Edmonton, Alberta

Conditions: Low Back Pain

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

NCT04124120

Recruiting

The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grfating (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grfating (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocar... Read More

The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grfating (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grfating (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocardial infarction, repeat revascularization, and hospital readmission for acute coronary syndrome or heart failure) in a cohort of 2,000 women randomized 1:1 to MAG or SAG (690 from the parent ROMA trial + 1,310 from ROMA:Women). Differences by important clinical and surgical subgroups (patients younger or older than 70 years, diabetics, racial and ethnic minorities, on vs off pump CABG, type of arterial grafts used) will also be evaluated. The women enrolled in the ongoing ROMA trial (anticipated to be approximately 690) will be included in ROMA:Women, increasing efficiency and reducing enrollment time. Hypothesis 1.0. MAG will reduce the incidence of major adverse cardiac and cerebrovascular events. Hypothesis 1.1. The improvement with MAG will be consistent across key subgroups. Aim 2: Determine the impact of MAG vs SAG on generic and disease-specific QOL, physical and mental health symptoms in women undergoing CABG. The investigators will compare generic (SF-12, EQ-5D) and disease-specific (Seattle Angina Questionnaire) QOL and physical and mental health symptoms (PROMIS-29) in a sub-cohort of 500 women randomized 1:1 to MAG or SAG (including those enrolled in ROMA:QOL). Differences by important subgroups (as defined above) will also be evaluated. Hypothesis 2.0. MAG will improve generic and disease-specific QOL compared to SAG. Hypothesis 2.1. MAG will improve physical and mental health symptoms compared to SAG. Hypothesis 2.2. The improvement with MAG will be consistent across key subgroups. Read Less

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

04/04/2025

Locations: Cedars-Sinai Medical Center, Los Angeles, California +140 locations

Cedars-Sinai Medical Center, Los Angeles, California

Pomona Valley Hospital Medical Center, Pomona, California

University of California, San Francisco, San Francisco, California

University of Colorado, Aurora, Colorado

Hartford Hospital, Hartford, Connecticut

Yale University Hospital, New Haven, Connecticut

Emory University, Atlanta, Georgia

University of Chicago, Chicago, Illinois

University of Iowa, Iowa City, Iowa

Johns Hopkins University, Baltimore, Maryland

Baystate Health, Springfield, Massachusetts

University of Massachusetts Chan Medical School, Worcester, Massachusetts

University of Michigan, Ann Arbor, Michigan

Corewell Health William Beaumont University Hospital, Royal Oak, Michigan

Washington University in St. Louis, Saint Louis, Missouri

Nebraska Heart Hospital, Lincoln, Nebraska

Methodist Physicians Health, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Englewood Health, Englewood, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

The Valley Hospital, Ridgewood, New Jersey

NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York

Weill Cornell Medicine, New York, New York

Columbia University Medical Center, New York, New York

Lenox Hill Hospital, New York, New York

New York Presbyterian Queens, Queens, New York

Duke University, Durham, North Carolina

East Carolina University, Greenville, North Carolina

Wake Forest University, Winston-Salem, North Carolina

Cleveland Clinic Foundation, Cleveland, Ohio

Ohio State University, Columbus, Ohio

Genesis Healthcare System, Zanesville, Ohio

University of Pennsylvania, Philadelphia, Pennsylvania

Allegheny General Hospital, Pittsburgh, Pennsylvania

Lankenau Medical Center, Wynnewood, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Baylor Scott & White Research Institute, Dallas, Texas

The University of Texas Medical Health Branch at Galveston, Galveston, Texas

Baylor College of Medicine, Houston, Texas

UT Health San Antonio, San Antonio, Texas

University of Utah, Salt Lake City, Utah

Victorian Heart Hospital, Clayton, Not set

The University of Melbourne, Melbourne, Not set

Medical University of Graz, Graz, Not set

Innsbruck Medical University, Innsbruck, Not set

Kepler University Hospital, Linz, Not set

Medical University of Vienna, Vienna, Not set

Krankenhaus Nord Vienna North Hospital, Vienna, Not set

Institute of Cardiology Porto Alegre, Porto Alegre, Not set

Heart Institute University of São Paulo, São Paulo, Not set

Instituto Dante Pazzanese de Cardiologia, Vila Mariana, Not set

St. Boniface General Hospital, Winnipeg, Manitoba

Horizon Health Network - Saint John Regional Hospital, Saint John, New Brunswick

NL Health Services, St. John's, Newfoundland and Labrador

Hamilton General Hospital, Hamilton, Ontario

London Health Sciences, London, Ontario

University of Ottawa Heart Institute, Ottawa, Ontario

Health Sciences North, Sudbury, Ontario

Sunnybrook Health Sciences, Toronto, Ontario

Toronto General Hospital, Toronto, Ontario

Montreal Heart Institute, Montréal, Quebec

University Hospital of Montreal, Montréal, Quebec

Royal Victoria Hospital, Montréal, Quebec

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Ste Foy, Quebec

Hopital Sacre-Coeur, Montréal, Not set

Fraser Clinical Trials, New Westminster, Not set

Fuwai Hospital China, Beijing, Beijing

Jilin Heart Hospital China, Changchun, Jilin

Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai

Teda Hospital Tianjin China, Tianjin, Tianjin

University Hospital Dubrava, Zagreb, Not set

University Hradec Králové, Hradec Králové, Not set

General University Hospital, Prague, Nové Město, Not set

Aalborg University Hospital, Aalborg, Not set

Rigshospitalet, Copenhagen, Not set

Universitäts-Herzzentrum Bad Krozingen Freiburg, Bad Krozingen, Baden-Wuerttemberg

HDZ NRW Bad Oeynhausen Germany, Bad Oeynhausen, Not set

Deutsches Herzzentrum der Charite, Berlin, Not set

Duisburg Heart Center, Duisburg, Not set

Dusseldorf University, Düsseldorf, Not set

University Hospital Erlangen, Erlangen, Not set

Essen University, Essen, Not set

Frankfurt University, Frankfurt, Not set

University Hospital of Giessen and Marburg, Gießen, Not set

University Medical Center of Göttingen, Göttingen, Not set

Jena University Hospital, Jena, Not set

Heart Center Herzzentrum, Leipzig, Leipzig, Not set

Robert-Bosch-Hospital Stuttgart Germany, Stuttgart, Not set

Krankenhaus der Barmherzigen Brüder Trier, Trier, Not set

G Kuppuswamy Naidu Memorial Hospital (GKNM), Coimbatore, Tamil Nadu

Star Hospitals - Hyderabad, India, Hyderabad, Telangana

Rambam Health Care Campus, Haifa, Not set

Anthea Hospital, Bari, Not set

Humanitas Gavazzeni of Bergamo, Bergamo, Not set

Fondazione Poliambulanza, Brescia, Not set

Maria Cecilia Hospital GVM, Cotignola, Not set

Careggi University Hospital, Florence, Not set

European Hospital, Roma, Not set

Universita' Cattolica del Sacro Cuore, Roma, Not set

Ospedale Le Molinette, Torino, Torino, Not set

Tokyo Medical and Dental University, Bunkyō-Ku, Tokyo

Saitama Medical University Japan, Saitama, Not set

Seoul National University Hospital, Seoul, Not set

Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seúl, Not set

Leiden University Medical Center, Leiden, South Holland

Erasmus Medical Center, Rotterdam, South Holland

Maastricht University Medical Centre, Maastricht, Not set

Acibadem-Sistina Hospital, Skopje, Not set

Medical University Gdansk, Gdańsk, Not set

Medical University of Silesia, Katowice, Not set

Zbigniew Religa Lower Silesian Heart Disease Centre, Zabrze, Not set

University Hospital Coimbra, Coimbra, Not set

Centro Hospitalar Lisboa Ocidental, Lisboa, Not set

Centro Hospitalar e Universitário Sao Joao, Porto, Not set

Centro Hospitalar e Universitário Sao João, Porto, Not set

National Research Medical Center of the Russian Academy of Sciences - Tomsk, Russia, Tomsk, Not set

Dedinje Cardiovascular Institute, Belgrade, Not set

National University of Singapore, Singapore, Not set

Hospital Universitario del Vinalopo, Elx, Alicante

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital Clinico de San Carlos, Madrid, Not set

NavarraBiomed, Pamplona, Not set

Sahlgrenska University Hospital, Gothenburg, Not set

Karonlinska University Hospital, Stockholm, Not set

National Taiwan University Hospital, Zhongzheng, Taipei

Blackpool Teaching Hospitals NHS Trust, Blackpool, Lancashire

Oxford University Hospitals NHS Trust, Multiple Locations, Oxford

University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, Staffordshire

Royal Papworth NHS Foundation Trust, Cambridge, Not set

NHS Golden Jubilee, Clydebank, Not set

The Royal Infirmary of Edinburgh, Edinburgh, Not set

Hull University Hospitals, Hull, Not set

University Hospitals of Leicester, Leicester, Not set

Liverpool Heart and Chest Hospital Foundation Trust, Liverpool, Not set

Guy's and St Thomas' NHS Foundation Trust, London, Not set

Imperial College Healthcare NHS Trust, London, Not set

St George's University Hospitals, London, Not set

Manchester University NHS Trust, Manchester, Not set

South Tees Hospitals NHS Trust, Middlesbrough, Not set

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, Not set

Royal Wolverhampton NHS Trust, Wolverhampton, Not set

Conditions: Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting

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Trial of the Impact of Sibeprenlimab on Immunoglobulin A Nephropathy Kidney Tissue

NCT06740526

Recruiting

This is a phase 2b open-label trial to characterize histopathological biomarkers of disease in immunoglobulin A nephropathy (IgAN) and demonstrate potential changes in response to sibeprenlimab.

Gender:

ALL

Ages:

16 years and above

Trial Updated:

04/04/2025

Locations: Clinical Research Site 330, Denver, Colorado +4 locations

Conditions: IgA Nephropathy

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Pilot Study of the 'Thriving With PMDs' Program

NCT06648382

Recruiting

This study is testing a self-help mental health program that was designed to help people cope with the challenges of living with a premenstrual disorder. Individuals with a premenstrual disorder - either premenstrual dysphoric disorder or premenstrual exacerbation of depression - will track their daily symptoms for two menstrual cycles before they complete the program, throughout the two-cycle program, and for an additional two cycles after accessing the program. This will allow the research tea... Read More

Gender:

FEMALE

Ages:

Between 18 years and 42 years

Trial Updated:

04/03/2025

Locations: University of Regina, Regina, Saskatchewan +1 locations

Conditions: Premenstrual Disorder, Premenstrual Dysphoric Disorder

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Prospective Clinical Registry Evaluating Contemporary MANTA Outcomes

NCT05936996

Recruiting

This is an observational study designed to evaluate the safety and clinical outcomes of the MANTA® Vascular Closure Device (VCD) (the MANTA® Device) in TAVR procedures. The study will enroll participants who are undergoing a TAVR procedure. The purpose of this study is to examine and collect data on outcomes of contemporary MANTA® large bore closure in standard of care (SOC) TAVR procedures with on-label use of the MANTA® device including appropriate patient selection and proper vascular access. Read More

Gender:

ALL

Ages:

21 years and above

Trial Updated:

04/03/2025

Locations: Baptist Health Medical Center-Jacksonville, Jacksonville, Florida +9 locations

Conditions: Femoral Arteriotomy Closure

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Single and Multiple Ascending Oral Doses of Avenanthramide

NCT06101784

Recruiting

Avenanthramides (AVA) are di-phenolic compounds found only in oats and are of interest due to suggested bioactivities, including antioxidant and anti-inflammatory effects in vitro and in vivo. Published data suggests that polyphenols can work as modifiers of signal transduction pathways to elicit their beneficial effects. These natural compounds express anti-inflammatory activity by modulation of pro-inflammatory gene expression such as cyclo-oxygenase, lipoxygenase, nitric oxide synthases and... Read More

Gender:

ALL

Ages:

Between 18 years and 60 years

Trial Updated:

04/03/2025

Locations: Montreal Heart Institute, Montréal, Quebec

Conditions: Inflammation

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All Clinical Trials in Canada

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