Study of Biomarkers in Gynecological Cancers
NCT03420118
Recruiting
In recent years, there has been a significant improvement in understanding the biology of cancer and this information has been used to improve cancer care and patient outcome. Research has shown that changes in some genes and/or proteins may be important indicators for certain cancers and response to treatments. Genes are molecules made up of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). DNA contain instructions for the development and functioning of the cells in the body and are pass... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Gynecologic Cancer
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Pulse Study: Peripheral Use of Low-dose Vasopressors for Safety and Efficacy in the Intensive Care Unit
NCT06920173
Recruiting
Using medications to increase blood pressure, called vasopressors, is invaluable in treating patients who have difficulty maintaining stable blood pressure. Vasopressors are usually infused through a central venous catheter (CVC), which is a flexible tube placed in the large vein of the neck, arm or groin. CVCs require a skilled clinician and often with an ultrasound to prevent complications such as a collapsed lung or bleeding. Alternatively, the infusion of vasopressors through a peripheral ve... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Kingston Health Sciences Center, Kingston, Ontario
Conditions: Shock, Peripheral Venous Catheterization, Central Venous Catheterization, Critically Ill Patients Admitted in ICU
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The UBC Long-distance Triathlon Adaptation Study
NCT06467656
Recruiting
The purpose of this study is to investigate the effect of 12-months of individualized endurance-training (swimming, cycling and running) on physiological and psychological adaptations in exercise naïve individuals. Due to the potential seasonal changes that naturally occur in individuals across a year (even without training) the investigators will also compare the exercise-trained group to a time-aligned control group.
Gender:
ALL
Ages:
Between 19 years and 39 years
Trial Updated:
04/02/2025
Locations: University of British Columbia, Kelowna, British Columbia
Conditions: Healthy Participants
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Micro-doses of Physical Activity for COPD
NCT05553223
Recruiting
Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than healthy individuals. Those who are the most sedentary have a greater risk of heart and blood vessel disease, which may lead to an early death. This project will investigate the effect of sitting still for 3 hours on blood vessel health in individuals with COPD. It will also in... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/02/2025
Locations: University of British Columbia, Kelowna, British Columbia
Conditions: Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction, Vascular Stiffness, Hypertension, Cardiovascular Diseases
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Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction
NCT05582044
Recruiting
The heart is a pump that must both fill and empty effectively to move blood; if it cannot move enough, heart failure may ensue. Approximately half of all adults living with heart failure have a form where the heart stiffens, which impairs its ability to fill. This form of heart failure particularly affects females and older adults. When people exercise, extra blood returns to the heart. The healthy heart can easily fill and move this extra blood to the muscles. However, when the heart's ability... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
04/02/2025
Locations: University of British Columbia, Kelowna, British Columbia
Conditions: Heart Failure With Preserved Ejection Fraction
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Personalized B-fructan Diet in Inflammatory Bowel Disease Patients
NCT05615779
Recruiting
This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our novel translational research findings.
Gender:
ALL
Ages:
Between 6 years and 39 years
Trial Updated:
04/02/2025
Locations: University of Alberta Hospital, Edmonton, Alberta +1 locations
Conditions: Inflammatory Bowel Diseases, Ulcerative Colitis
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Passive Heat Therapy for People With COPD
NCT05962164
Recruiting
People with Chronic Obstructive Pulmonary Disease (COPD) often develop high blood pressure and heart disease due to their sedentary lifestyle and difficulty exercising. The investigators will test if heating can mimic the health benefits of exercise by monitoring the increase in leg blood-flow using ultrasound during a 45-minute hot-water footbath. The patients will then undergo 6-weeks of hot-water footbaths to examine whether the changes to blood-flow lead to improvements in blood pressure and... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
04/02/2025
Locations: University of British Columbia, Kelowna, British Columbia
Conditions: COPD, Cardiovascular Diseases
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Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)
NCT06050694
Recruiting
This is a phase ll study of participants with untreated diffuse large B Cell lymphoma (DLBCL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario +1 locations
Conditions: Diffuse Large B Cell Lymphoma (DLBCL)
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Dapagliflozin in STEMI
NCT06174753
Recruiting
The goal of this clinical trial is to assess the safety and efficacy of SGLT2i in limiting infarct size in patients with STEMI referred for PPCI. Eligible STEMI patients enrolled into the trial will be randomized to a SGLT2i or placebo. Cardiovascular Magnetic Resonance (CMR) imaging will be used to determine the infarct size.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: University of Ottawa Heart Institute, Ottawa, Ontario
Conditions: ST Elevation Myocardial Infarction, Myocardial Infarction
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SiFi vs FNB Local Anesthesia for Hip Fracture Surgeries
NCT06296758
Recruiting
The goal of this clinical trial is to compare two commonly used local/regional anesthesia techniques in adults patients undergoing hip fracture surgery. The main question\[s\] it aims to answer are: • the impact of both interventions on patient level of pain. • impact on postoperative analgesics administered Participants will be randomly assigned to one of two local/regional anesthesia techniques, either femoral nerve block (FNB) or suprainguinal fascia iliaca block (SiFi). Both techniques are t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: University of Alberta Hospital, Edmonton, Alberta
Conditions: Hip Fractures, Surgery, Anesthesia, Local
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Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
NCT02823821
Recruiting
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Royal Adelaide Hospital, Adelaide, Not set +263 locations
Conditions: End-Stage Kidney Disease
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Study to Evaluate the Safety and Efficacy of Daily Subcutaneous Metreleptin Treatment in Subjects With PL
NCT05164341
Recruiting
This is a Phase III, double-blind, placebo-controlled, safety and efficacy study of daily SC metreleptin in subjects with Partial Lipodystrophy.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
04/01/2025
Locations: University of Alabama, Birmingham, Alabama +30 locations
Conditions: Partial Lipodystrophy
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