Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)
NCT06050694
Recruiting
This is a phase ll study of participants with untreated diffuse large B Cell lymphoma (DLBCL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario +1 locations
Conditions: Diffuse Large B Cell Lymphoma (DLBCL)
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Pulse Study: Peripheral Use of Low-dose Vasopressors for Safety and Efficacy in the Intensive Care Unit
NCT06920173
Recruiting
Using medications to increase blood pressure, called vasopressors, is invaluable in treating patients who have difficulty maintaining stable blood pressure. Vasopressors are usually infused through a central venous catheter (CVC), which is a flexible tube placed in the large vein of the neck, arm or groin. CVCs require a skilled clinician and often with an ultrasound to prevent complications such as a collapsed lung or bleeding. Alternatively, the infusion of vasopressors through a peripheral ve... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Kingston Health Sciences Center, Kingston, Ontario
Conditions: Shock, Peripheral Venous Catheterization, Central Venous Catheterization, Critically Ill Patients Admitted in ICU
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Dapagliflozin in STEMI
NCT06174753
Recruiting
The goal of this clinical trial is to assess the safety and efficacy of SGLT2i in limiting infarct size in patients with STEMI referred for PPCI. Eligible STEMI patients enrolled into the trial will be randomized to a SGLT2i or placebo. Cardiovascular Magnetic Resonance (CMR) imaging will be used to determine the infarct size.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: University of Ottawa Heart Institute, Ottawa, Ontario
Conditions: ST Elevation Myocardial Infarction, Myocardial Infarction
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SiFi vs FNB Local Anesthesia for Hip Fracture Surgeries
NCT06296758
Recruiting
The goal of this clinical trial is to compare two commonly used local/regional anesthesia techniques in adults patients undergoing hip fracture surgery. The main question\[s\] it aims to answer are: • the impact of both interventions on patient level of pain. • impact on postoperative analgesics administered Participants will be randomly assigned to one of two local/regional anesthesia techniques, either femoral nerve block (FNB) or suprainguinal fascia iliaca block (SiFi). Both techniques are t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: University of Alberta Hospital, Edmonton, Alberta
Conditions: Hip Fractures, Surgery, Anesthesia, Local
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WATER IV Prostate Cancer
NCT06651632
Recruiting
This is a multicenter, prospective, randomized clinical trial that aims to assess the safety and efficacy of Aquablation Therapy in men with low-risk to intermediate to high-risk localized prostate cancer who are candidates for, or have opted for, prostatectomy. Participants will be randomized to either Aquablation Therapy or radical prostatectomy and followed up to 10 years.
Gender:
MALE
Ages:
45 years and above
Trial Updated:
04/01/2025
Locations: Arizona State Urological Institute, Chandler, Arizona +38 locations
Conditions: Localized Prostate Cancer
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Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
NCT02823821
Recruiting
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Royal Adelaide Hospital, Adelaide, Not set +263 locations
Conditions: End-Stage Kidney Disease
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COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation
NCT04642430
Recruiting
Atrial Fibrillation (AF) affects 200,000 Canadians and increases risk of stroke, morbidity and mortality. Having a stroke can affect a patient's ability to speak, eat, walk, work, care for themselves, and interact with others. Not only can it ruin one's life, but it can also be fatal. A stroke occurs when blood flow to the brain is blocked by a clot, depriving brain cells of oxygen. In people with atrial fibrillation, blood flow is sluggish in the top chambers of the heart, and blood clots can f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Victoria Cardiac Arrhythmia Trials, Victoria, British Columbia +7 locations
Conditions: Atrial Fibrillation
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Study to Evaluate the Safety and Efficacy of Daily Subcutaneous Metreleptin Treatment in Subjects With PL
NCT05164341
Recruiting
This is a Phase III, double-blind, placebo-controlled, safety and efficacy study of daily SC metreleptin in subjects with Partial Lipodystrophy.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
04/01/2025
Locations: University of Alabama, Birmingham, Alabama +30 locations
Conditions: Partial Lipodystrophy
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Effects of Tagatose on Glycemic Response and Gastrointestinal Microbiota in Healthy Adults
NCT06920641
Recruiting
The primary objective of this clinical-trial is to determine, in subjects with impaired fasting glucose (IFG) and/or insulin resistance (IR), if tagatose meets the definition of a prebiotic, namely that consuming tagatose for 4 weeks selectively stimulates the selective growth of bacteria in the colon and is associated with a health benefit (oral glucose tolerance) when compared to consuming the control treatment (10g sucrose) for 4 weeks.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/01/2025
Locations: INQUIS Clinical Research, Toronto, Ontario
Conditions: Glucose Intolerance, Microbial Colonization
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A Feasibility Randomized Trial Evaluating Early vs Late Stent Removal Following Radical Cystectomy and Ileal Conduit Formation for Bladder Cancer
NCT06595446
Recruiting
Bladder cancer is the 4th most common cancer in men and 5th most common type of cancer in Canada. Urothelial cancer accounts for approximately 90% of malignancies. At diagnosis, over 75% of cases are classified as non-muscle invasive (NMIBC), and with appropriate treatment, the majority of these patients achieve positive outcomes. The progression rate of NMIBC to Muscle-invasive bladder cancer (MIBC) varies between 5-50% at 5 years dependent on histopathological features such as grade, stage, pr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Victoria Hospital, London, Ontario
Conditions: Bladder Cancer Requiring Cystectomy, Ileal Conduit, Urinary Diversion
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A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of ALD-102 Solution in Subjects With Alopecia Areata
NCT06826196
Recruiting
The goal of this first-in-human clinical trial is to learn if ALD-102 Solution is safe and well tolerated following injections in the scalp in subjects with alopecia areata. The study will also learn about the effect of ALD-102 on hair regrowth in treatment areas. The researchers will compare the effects of ALD-102 Solution (drug) to placebo (saline solution that contains no drug). Study participants will have two treatment areas selected on the scalp and will receive randomly ALD-102 Solution (... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/01/2025
Locations: Options Research Group, West Lafayette, Indiana +4 locations
Conditions: Alopecia Areata (AA)
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A Multicenter Multinational Observational Study of Children With Hypochondroplasia
NCT06212947
Recruiting
This study will assess growth over time and the clinical course of HCH in children by collecting growth measurements and other variables of interest.
Gender:
ALL
Ages:
15 years and below
Trial Updated:
04/01/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +42 locations
Conditions: Hypochondroplasia
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