Clinical Trials & Research Studies in Canada(Updated 8/25)

RAPID AFib Decision Aid for Stroke Prevention in Atrial Fibrillation

NCT05900414

Recruiting

The goal of this pilot clinical trial is to evaluate the utility of a new electronic patient decision aid for stroke prevention therapy in patients with atrial fibrillation. The main questions it aims to answer are: Is the patient decision aid acceptable to both patients and physicians? Does the patient decision aid lead to more effective shared decision-making than standard care among patients with atrial fibrillation who are considering stroke prevention therapy? Participants with a recent di... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/27/2025

Locations: Calgary Zone, Alberta Health Services, Calgary, Alberta +1 locations

Conditions: Atrial Fibrillation

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Hip Replacement System (HRS-P) in Primary Total Hip Arthroplasty

NCT02836262

Recruiting

To evaluate effectiveness and safety of HHRS in subjects undergoing total hip arthroplasty (THA). Effectiveness will be evaluated using patient-reported, clinical, radiologic, and radiostereometric outcomes. Safety will be evaluated through the collection of device-related and unanticipated device-related adverse events.

Gender:

ALL

Ages:

Between 65 years and 79 years

Trial Updated:

03/26/2025

Locations: Orthopaedic Innovation Centre, Winnipeg, Manitoba

Conditions: Osteoarthritis of Hip

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Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain

NCT03643822

Recruiting

The aim of this multi-centered study is to evaluate the effects of two distinct Adductor Canal Block (ACB) adjuncts, dexamethasone and dexmedetomidine, and their combination, on postoperative analgesia in patients undergoing Anterior Cruciate Ligament (ACL) Repair.

Gender:

ALL

Ages:

Between 18 years and 50 years

Trial Updated:

03/26/2025

Locations: Women's College Hospital, Toronto, Ontario

Conditions: ACL Injury

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Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)

NCT04185883

Recruiting

To evaluate the safety and tolerability of sotorasib administered in investigational regimens in adult participants with KRAS p.G12C mutant advanced solid tumors.

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

03/26/2025

Locations: Arizona Oncology Associates Professional Corporation, Tucson, Arizona +89 locations

Arizona Oncology Associates Professional Corporation, Tucson, Arizona

City of Hope National Medical Center, Duarte, California

University of California San Diego Moores Cancer Center, La Jolla, California

Loma Linda University Cancer Center, Loma Linda, California

University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California

University of California Davis Medical Center, Sacramento, California

University of California San Francisco Mission Bay Campus, San Francisco, California

University of California Los Angeles, Santa Monica, California

Rocky Mountain Cancer Centers Denver Midtown, Denver, Colorado

Sarah Cannon Research Institute, Denver, Colorado

Yale New Haven Hospital, New Haven, Connecticut

Norwalk Hospital, Norwalk, Connecticut

Memorial Cancer Institute, Pembroke Pines, Florida

Moffitt Cancer Center, Tampa, Florida

Emory University, Atlanta, Georgia

Northwestern University, Chicago, Illinois

University of Chicago, Chicago, Illinois

Indiana University, Indianapolis, Indiana

University of Iowa Hospitals and Clinics, Iowa City, Iowa

Johns Hopkins University, Baltimore, Maryland

University of Michigan, Ann Arbor, Michigan

Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion), Detroit, Michigan

Washington University, Saint Louis, Missouri

Montefiore Medical Center, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University Irving Medical Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Levine Cancer Institute, Charlotte, North Carolina

Duke University, Durham, North Carolina

University of Cincinnati Medical Center, Cincinnati, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Providence Portland Medical Center, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Thomas Jefferson University, Philadelphia, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

University of Pennsylvania, Philadelphia, Pennsylvania

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Gibbs Cancer Center and Research Institute - Spartanburg, Spartanburg, South Carolina

Avera Cancer Institute, Sioux Falls, South Dakota

United States Oncology Regulatory Affairs Corporate Office, Nashville, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

Texas Oncology Central-South, Austin, Texas

Mary Crowley Cancer Research, Dallas, Texas

University of Texas Southwestern Medical Center, Dallas, Texas

Oncology Consultants, Houston, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

US Oncology Research Investigational Products Center, The Woodlands, Texas

Texas Oncology Northeast Texas, Tyler, Texas

Huntsman Cancer Institute, Salt Lake City, Utah

University of Virginia Cancer Center, Charlottesville, Virginia

Virginia Cancer Specialists, PC, Fairfax, Virginia

Fred Hutchinson Cancer Center, Seattle, Washington

Northwest Medical Specialties, PLLC, Tacoma, Washington

Northwest Cancer Specialists - Vancouver, Vancouver, Washington

Nepean Cancer Centre, Kingswood, New South Wales

GenesisCare -North Shore Oncology, St Leonards, New South Wales

Icon Cancer Care South Brisbane, South Brisbane, Queensland

The Queen Elizabeth Hospital, Woodville South, South Australia

St John of God Healthcare, Subiaco, Western Australia

Medizinische Universitaet Graz, Graz, Not set

Landeskrankenhaus Salzburg, Salzburg, Not set

Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Bruxelles, Not set

Universitair Ziekenhuis Antwerpen, Edegem, Not set

CHU de Quebec Hopital de l Enfant Jesus, Quebec, Not set

Charite Universitaetsmedizin Berlin, Campus Virchow, Berlin, Not set

Universitaetsklinikum Dresden, Dresden, Not set

Universitaetsklinikum Essen, Essen, Not set

Universitatsklinikum Koln, Koeln, Not set

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set

Azienda Ospedaliero Universitaria Pisana, Pisa, Not set

Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona, Not set

Aichi Cancer Center, Nagoya-shi, Aichi

National Cancer Center Hospital East, Kashiwa-shi, Chiba

The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo

Seoul National University Hospital, Seoul, Not set

The Catholic University of Korea Seoul St Marys Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Universitair Medisch Centrum Utrecht, Utrecht, Not set

Hospital Universitari Vall d Hebron, Barcelona, Cataluña

Hospital Clinic i Provincial de Barcelona, Barcelona, Cataluña

Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals, Hospitalet de Llobregat, Cataluña

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid

Hospital Universitario Ramon y Cajal, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

National Cheng Kung University Hospital, Tainan, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan, Not set

Sarah Cannon Research Institute UK, London, Not set

Conditions: Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation

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Chest Lymph Node Sampling in Patients with Advanced Lung Cancer to Be Treated with Curative-intent Radiation Treatment

NCT04852588

Recruiting

This study will investigate the role of sampling suspicious chest lymph nodes with a procedure called endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA) or transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) in patients planned to receive radical dose radiation. This study will use Stereotactic Ablative Radiotherapy (SABR) for treatment methods. SABR is a newer radiation treatment that delivers high-dose, precise radiation to small tumors and can be... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/26/2025

Locations: London Health Sciences Centre - London Regional Cancer Program, London, Ontario +1 locations

Conditions: Non-Small Cell Lung Cancer

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The Young Adult Clinic (YAC) Study

NCT05147974

Recruiting

The overarching aim of the Young Adult Clinic (YAC) study is to evaluate the DOZE app, a digital, transdiagnostic behavioral sleep medicine and self-management approach in young adult patients (ages 18-25) with chronic pain.

Gender:

ALL

Ages:

Between 18 years and 25 years

Trial Updated:

03/26/2025

Locations: Women's College Hospital, Toronto, Ontario

Conditions: Insomnia, Chronic Pain, Insomnia Due to Medical Condition

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I-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: a Randomized, Midazolam-Controlled Clinical Trial

NCT06480500

Recruiting

Approximately four thousand Canadians die by suicide every year, and suicide is the second leading cause of death in youth and young adults (15-34 years). Most people with depression experience thoughts of suicide and many will also plan and/or attempt suicide at some time in their life. There is an urgent need for new scalable treatments that can effectively reduce suicidality in people with depression. Cognitive behavioural therapy (CBT) reduces suicidal thoughts and behaviours, and can be de... Read More

Gender:

ALL

Ages:

Between 21 years and 65 years

Trial Updated:

03/26/2025

Locations: Toronto General Hospital, Toronto, Ontario +1 locations

Conditions: Major Depressive Disorder, Suicide, Treatment Resistant Depression

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Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients

NCT05889494

Recruiting

The goal of this pilot trial is to test a protocol for a planned Canada-wide clinical trial looking at whether or not the use of a patients own blood works as good as the current standard of care using donated blood products to reduce blood loss in adult patients having heart surgery. The main questions this study aims to answer are: * Is the protocol practical, effective, and efficient. * Does the use of a patients own blood lower the following: bleeding, the amount donated blood products giv... Read More

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

03/26/2025

Locations: University of Alberta, Edmonton, Alberta

Conditions: Postoperative Hemorrhage, Postoperative Anemia, Postoperative Blood Loss

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Refractive Accuracy of Argos in Conjunction With the Alcon Vision Suite Following Implantation of Presbyopia Correcting IOLs

NCT05901597

Recruiting

The objective is to assess refractive accuracy of the Alcon Vision Suite (with Argos biometer) following Clareon PanOptix and AcrySof Vivity IOL implantation.

Gender:

ALL

Ages:

50 years and above

Trial Updated:

03/26/2025

Locations: Valley Laser Eye Centre, Abbotsford, British Columbia

Conditions: Cataract

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The Effect of a Group Exercise Intervention on Balance in People With Knee Osteoarthritis: a Pilot Study

NCT06807541

Recruiting

In this study, the investigators want to find out if a 12-week exercise program improves balance in people with knee osteoarthritis. This study will involve two visits to the School of Kinesiology at the University of the Fraser Valley (Chilliwack campus). Each visit will last approximately one hour. Participants will be asked to fill out questionnaires and complete a balance test. In between visits, participants will complete 12 weeks of an exercise program specifically designed for adults wit... Read More

Gender:

ALL

Ages:

All

Trial Updated:

03/26/2025

Locations: University of the Fraser Valley, Chilliwack, British Columbia +1 locations

Conditions: Knee Osteoarthritis

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Prevention Messages for EGMs: Effects on Behaviours and Cognitions

NCT06341504

Recruiting

The goals of this randomized controlled trial are to test the manifold effects of prevention pop-up messages on participants' behaviours, cognitions and affects. This study is conducted among regular EGMs' players (defined as having played EGMs at least once every two weeks for the past 12 months) who are not classified as probable pathological gamblers by the PGSI. After answering a series of short questionnaires by phone, participants are asked to schedule a gambling session which is done in... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/26/2025

Locations: Centre québécois d'excellence pour la prévention et le traitement du jeu, Québec, Not set

Conditions: Gambling

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Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake

NCT06571149

Recruiting

DO-IT is an international, multicenter, prospective, two-arm, randomized, open label, blinded endpoint superiority trial determining the safety and efficacy of intravenous thrombolysis (IVT) in participants experiencing an acute ischemic stroke (AIS) with recent (within the last 48 hours) intake of direct oral anticoagulant (DOAC). For this purpose, 906 adult participants experiencing an AIS with recent DOAC intake will be enrolled at several high-volume international stroke centers and randomly... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/25/2025

Locations: UZ Leuven, Leuven, Not set +13 locations

Conditions: Ischemic Stroke

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