Semaglutide and Preoperative Residual Gastric Volumes
NCT06263595
Recruiting
Given the pharmacodynamic and pharmacokinetic properties of glucagon-like peptide-1 (GLP-1) agonists, the Canadian Anesthesiologists' Society has recognized that patients on GLP-1 agonists may have an increased aspiration risk due to a 'full stomach,' even after following preoperative fasting guidelines. In other words, safe fasting timelines are not known in individuals taking GLP-1 agonists, as demonstrated by recent case reports of patients who either retained or regurgitated stomach contents... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: South Health Campus, Calgary, Alberta
Conditions: Pulmonary Aspiration
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End Tidal Carbon Dioxide Concentration and Depth of Anesthesia in Children
NCT06303518
Recruiting
Carbon Dioxide (CO2) is a by-product of metabolism and is removed from the body when we breathe out. High levels of CO2 can affect the nervous system and cause us to be sleepy or sedated. Research suggests that high levels of CO2 may benefit patients who are asleep under anesthesia, such as by reducing infection rates, nausea, or recovery from anesthesia . CO2 may also reduce pain signals or the medication required to keep patients asleep during anesthesia; this has not been researched in childr... Read More
Gender:
ALL
Ages:
Between 3 years and 11 years
Trial Updated:
03/24/2025
Locations: BC Children's Hospital, Vancouver, British Columbia
Conditions: Anesthesia, Hypercapnia, Hypocapnia
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Tech-wise Driver (Technology Acceptance of Targeted ADAS for Older Adults)
NCT06437665
Recruiting
The tech-wise driver: Exploring the sustained efficacy and technology acceptance of targeted ADAS for older drivers A significant percentage of road traffic fatalities registered in Canada occurred among older adults. According to the studies, the Advanced Driver Assistance Systems (ADAS) can enhance the safety and mitigate the age-related declines of older drivers. Whether sustained use results in declines in driving performance in older drivers relying on ADAS remains largely unexplored. This... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/24/2025
Locations: Western University, London, Ontario
Conditions: Older Adults, Driving, Simulator
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Comprehensive Health Assessment for My Plan: Initial Implementation Study (CHAMP Implementation Study)
NCT06464471
Recruiting
The current standard preoperative assessment does not consider the needs of older adults undergoing non-oncological surgery. To enhance the treatment decision-making and planning for older adult surgical patients, the British Geriatric Society and the American Society of Colon and Rectal Surgeons recommend the implementation of preoperative GA for all older adults. Geriatric assessment (GA) predicts treatment toxicity and overall mortality in older adults with complex health problems. However, i... Read More
Gender:
ALL
Ages:
70 years and above
Trial Updated:
03/24/2025
Locations: University Health Network, Toronto, Ontario
Conditions: Cancer, Older Adults
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A Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of mRNA-3705 in Participants With Isolated Methylmalonic Acidemia
NCT04899310
Recruiting
This is a study of mRNA-3705 in participants with isolated elevated methylmalonic acid (MMA) due to methylmalonyl-coenzyme A (CoA) mutase (MUT) deficiency. The main goal of the study is to assess safety, pharmacokinetics, and pharmacodynamics of mRNA-3705.
Gender:
ALL
Ages:
1 year and above
Trial Updated:
03/22/2025
Locations: UCLA Medical Center, Los Angeles, California +16 locations
Conditions: Methylmalonic Acidemia
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A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Type 1a (GSD1a)
NCT05095727
Recruiting
The main goal of this trial is to evaluate the safety and tolerability of mRNA-3745 via intravenous (IV) administration in adult and pediatric participants with GSD1a.
Gender:
ALL
Ages:
6 years and above
Trial Updated:
03/22/2025
Locations: University of Connecticut Health Center, Farmington, Connecticut +15 locations
Conditions: Glycogen Storage Disease
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A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Ulcerative Colitis (ROSETTA)
NCT06127043
Recruiting
ROSETTA STUDY: This study will evaluate the safety, tolerability, and efficacy of Rosnilimab in subjects with moderate to severe ulcerative colitis (UC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/22/2025
Locations: AnaptysBio Investigational Site 10-115, Phoenix, Arizona +99 locations
Conditions: Ulcerative Colitis
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TSA vs RSA in Glenohumeral Osteoarthritis
NCT04228419
Recruiting
This study will compare total shoulder arthroplasty (TSA) reverse shoulder arthroplasty (RSA) procedures, in the context of a prospective, randomized-controlled trial to determine the optimal treatment in patients 65 years of age and older, and equal to or less than 15 degrees of glenoid retroversion, who have glenohumeral osteoarthritis.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/21/2025
Locations: University of Alberta, Edmonton, Alberta +3 locations
Conditions: Osteoarthritis of the Shoulder
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The Use of Transcranial Direct Current Stimulation (tDCS) in Adults with Developmental Disabilities
NCT04732052
Recruiting
Aggressive behaviours are highly prevalent among people with developmental disabilities, both in community and inpatient or residential settings, with adverse consequences for the individuals involved and others. Some predictive factors, particularly impulsivity, are dynamic with neurobiological underpinnings, and as such amenable to change or neuromodulation using non-invasive brain stimulation techniques. With this in mind, we designed an experimental protocol to determine the efficacy of tran... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/21/2025
Locations: Providence Care Hospital, Kingston, Ontario
Conditions: Aggression
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My MS and My Menstrual Cycle
NCT06832293
Recruiting
The goal of this observational study is to understand how MS symptoms change during different phases of the menstrual cycle in individuals who menstruate living with MS (Multiple Sclerosis). The main questions it aims to answer are: 1. Does fatigue get worse during certain phases of the menstrual cycle? 2. How do symptoms like thinking skills, pain, and mobility change throughout the cycle? Participants will: * Use the My Normative app to track their menstrual cycle and MS symptoms. * Comple... Read More
Gender:
FEMALE
Ages:
16 years and above
Trial Updated:
03/21/2025
Locations: University of Calgary, Calgary, Alberta +1 locations
Conditions: Multiple Sclerosis, Menstrual Cycle
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Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects with Discoid Lupus Erythematosus
NCT06261021
Recruiting
This study is a single-blind, intraindividual study to evaluate the efficacy of ruxolitinib 1.5 % cream in adult subjects with discoid lupus erythematosus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/21/2025
Locations: INNO-6051 Site 03, Fredericton, New Brunswick +1 locations
Conditions: Discoid Lupus Erythematosus
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Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery
NCT06357234
Recruiting
This research trial will measure how useful Aprepitant is in preventing nausea and vomiting in children having surgery to correct scoliosis (curvature of the spine).
Gender:
ALL
Ages:
Between 8 years and 19 years
Trial Updated:
03/21/2025
Locations: IWK Health Sciences Center, Halifax, Nova Scotia
Conditions: Spinal Fusion, Nausea and Vomiting, Postoperative, Anesthesia
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