A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Ulcerative Colitis (ROSETTA)
NCT06127043
Recruiting
ROSETTA STUDY: This study will evaluate the safety, tolerability, and efficacy of Rosnilimab in subjects with moderate to severe ulcerative colitis (UC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/22/2025
Locations: AnaptysBio Investigational Site 10-115, Phoenix, Arizona +99 locations
Conditions: Ulcerative Colitis
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My MS and My Menstrual Cycle
NCT06832293
Recruiting
The goal of this observational study is to understand how MS symptoms change during different phases of the menstrual cycle in individuals who menstruate living with MS (Multiple Sclerosis). The main questions it aims to answer are: 1. Does fatigue get worse during certain phases of the menstrual cycle? 2. How do symptoms like thinking skills, pain, and mobility change throughout the cycle? Participants will: * Use the My Normative app to track their menstrual cycle and MS symptoms. * Comple... Read More
Gender:
FEMALE
Ages:
16 years and above
Trial Updated:
03/21/2025
Locations: University of Calgary, Calgary, Alberta +1 locations
Conditions: Multiple Sclerosis, Menstrual Cycle
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TSA vs RSA in Glenohumeral Osteoarthritis
NCT04228419
Recruiting
This study will compare total shoulder arthroplasty (TSA) reverse shoulder arthroplasty (RSA) procedures, in the context of a prospective, randomized-controlled trial to determine the optimal treatment in patients 65 years of age and older, and equal to or less than 15 degrees of glenoid retroversion, who have glenohumeral osteoarthritis.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/21/2025
Locations: University of Alberta, Edmonton, Alberta +3 locations
Conditions: Osteoarthritis of the Shoulder
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The Use of Transcranial Direct Current Stimulation (tDCS) in Adults with Developmental Disabilities
NCT04732052
Recruiting
Aggressive behaviours are highly prevalent among people with developmental disabilities, both in community and inpatient or residential settings, with adverse consequences for the individuals involved and others. Some predictive factors, particularly impulsivity, are dynamic with neurobiological underpinnings, and as such amenable to change or neuromodulation using non-invasive brain stimulation techniques. With this in mind, we designed an experimental protocol to determine the efficacy of tran... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/21/2025
Locations: Providence Care Hospital, Kingston, Ontario
Conditions: Aggression
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Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects with Discoid Lupus Erythematosus
NCT06261021
Recruiting
This study is a single-blind, intraindividual study to evaluate the efficacy of ruxolitinib 1.5 % cream in adult subjects with discoid lupus erythematosus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/21/2025
Locations: INNO-6051 Site 03, Fredericton, New Brunswick +1 locations
Conditions: Discoid Lupus Erythematosus
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Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery
NCT06357234
Recruiting
This research trial will measure how useful Aprepitant is in preventing nausea and vomiting in children having surgery to correct scoliosis (curvature of the spine).
Gender:
ALL
Ages:
Between 8 years and 19 years
Trial Updated:
03/21/2025
Locations: IWK Health Sciences Center, Halifax, Nova Scotia
Conditions: Spinal Fusion, Nausea and Vomiting, Postoperative, Anesthesia
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Benefits of Choir for Older Adults with Unaddressed Hearing Loss (WP2)
NCT06580847
Recruiting
Unaddressed age-related hearing loss is highly prevalent among older adults, typified by negative consequences for speech-in-noise perception and psychosocial wellbeing. There is promising evidence that group singing may enhance speech-in-noise perception and psychosocial wellbeing. However, there is a lack of robust evidence, primarily due to the literature being based on small sample sizes, single site studies, and a lack of randomized controlled trials. Hence, to address these concerns, this... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/20/2025
Locations: Brain and Creativity Institute, University of Southern California, Los Angeles, California +6 locations
Conditions: Hearing Loss, Age-Related, Speech Intelligibility, Psychosocial Functioning
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Cephea Early Feasibility Study
NCT05061004
Recruiting
The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral valve disease (including mitral regurgitation, mitral stenosis and mixed mitral valve disease) in whom transcatheter therapy is deemed more appropriate than open heart surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California +20 locations
Conditions: Mitral Regurgitation
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A Platform Trial for Gram Negative Bloodstream Infections
NCT06537609
Recruiting
BALANCE+ is a perpetual multiple domain randomized controlled platform trial to evaluate various treatment strategies for Gram-negative bloodstream infections (GN BSIs). Each domain addresses critical questions in the management of GN BSIs, aiming to refine treatment strategies, enhance patient outcomes, and reduce antimicrobial resistance. The initial vanguard pilot RCT (NCT05893147) started on 29 August 2023 and has successfully completed the pilot phase on 24-Apr-2024. All patients enrolled... Read More
Gender:
ALL
Ages:
Between 0 years and 130 years
Trial Updated:
03/20/2025
Locations: Redcliffe Hospital, Redcliffe, Queensland +22 locations
Conditions: Gram-negative Bacteremia
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A Study of YL201 in Patients with Advanced Solid Tumors
NCT05434234
Recruiting
This is a phase 1, multicenter, nonrandomized, open-label, first-in-human study of YL201 conducted in China and the United States. The study will include 2 parts: a dose escalation part (Part 1) followed by a dose expansion part (Part 2). Part 1 will estimate the MTD/RED(s) in dose escalation cohorts of patients with advanced solid tumors unresponsive to currently available therapies or for whom no standard therapy is available. Part 2 will include patients with selected advanced solid tumor t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: University California San Diego Moores Cancer Center, La Jolla, California +42 locations
Conditions: Advanced Solid Tumor
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Genome Analysis Across Populations in Inflammatory Bowel Disease
NCT06042387
Recruiting
Objective: To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD within affected populations.
Gender:
ALL
Ages:
All
Trial Updated:
03/20/2025
Locations: Sinai Health System, Toronto, Ontario
Conditions: Ulcerative Colitis, Healthy, Crohn Disease, Inflammatory Bowel Diseases
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Comprehensive Segmental Revision System
NCT03270982
Recruiting
Clinical Data evaluation to document the performance and clinical outcomes of the Comprehensive Segmental Revision System.
Gender:
ALL
Ages:
All
Trial Updated:
03/19/2025
Locations: Nova Scotia Health Authority, Halifax, Nova Scotia +3 locations
Conditions: Degenerative Disease, Oncology, Revision Surgery, Trauma, Rheumatoid Arthritis
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