Canadian Critical Care Comparative Effectiveness Platform
NCT06605144
Recruiting
The Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC) is an international multi-centered randomized adaptive platform clinical trial. CEPEC will evaluate supportive care interventions that are used routinely in intensive care units throughout the world.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Research Centre of the CHUS, Sherbrooke, Quebec
Conditions: Intensive Care Unit ICU
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Impact of Hormonal Therapy on Prostate Cancer Recurrence After Radical Prostatectomy
NCT05169112
Recruiting
Prostate cancer is the most common cancer in men and radical prostatectomy is the most frequent treatment for this disease. Unfortunately, approximately 40% of patients will develop recurrence after surgery, requiring additional salvage radiation. Salvage radiation after recurrence is successful in less than half of these men and most of those die from their disease. Measures to prevent recurrence are an important research priority for prostate cancer patients and their families. Hormonal therap... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Nova Scotia Health, Halifax, Nova Scotia +2 locations
Conditions: Prostate Cancer
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A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
NCT05372354
Recruiting
The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: UAB Comprehensive Cancer Center, Birmingham, Alabama +16 locations
Conditions: Multiple Myeloma
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Response Variability to Exercise
NCT05496751
Recruiting
In this proposal, the investigators challenge the assumption that following the physical activity guidelines implies benefit for ALL adults, and that if benefit is not achieved in response to first line therapy, it will be by simply exercising more. Thus, for improving cardiorespiratory fitness and cardiometabolic risk factors, unanswered questions include: 1) To what extent, regardless of increasing exercise intensity or amount, is exercise not associated with benefit? Demonstration of a resist... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
03/17/2025
Locations: School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario
Conditions: Exercise, Cardiorespiratory Fitness
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ORIC-114 in Combination with Subcutaneous Amivantamab in Patients with EGFR Exon20 Insertion Mutant NSCLC
NCT06816992
Recruiting
The purpose of this study is to establish the recommended phase 2 dose (RP2D), safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of ORIC-114 in combination with subcutaneous (SC) amivantamab in patients with advanced or metastatic NSCLC harboring an EGFR exon 20 insertion mutation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: NYU Langone Health, New York, New York +3 locations
Conditions: Solid Tumors, EGFR Exon 20 Insertion Mutations, NSCLC, EGFR-mutated NSCLC
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Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study
NCT06225232
Recruiting
Cannabis is the most commonly used psychoactive substance in Canada (Lowry \& Corsi, 2020). A sub-group of cannabis users develop a condition known as Cannabis Use Disorder (CUD), which is defined as a regular pattern of cannabis use that causes performance difficulty at work, school and relationships (Hasin et al., 2013). A review of current treatments available for CUD indicate the lack of a pharmacological and psychological treatment with high success rates, which highlights the importance of... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/17/2025
Locations: MacAnxiety Research Centre, Hamilton, Ontario
Conditions: Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe
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Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
NCT06233825
Recruiting
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma. The highest rates of skeletal muscle mass and strength loss occur during the 2-week post-surgery period, considered the early phase of outpatient recovery. Alternative to resistance exercise and pharmacology, nutritional intervention represents one strategy to combat skel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Queen's University, Kingston, Ontario
Conditions: Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
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Quantitative Ultrasound Techniques for Diagnosis of Nonalcoholic Steatohepatitis
NCT03572465
Recruiting
Nonalcoholic fatty liver disease is the most common liver disease in Western countries, due in large part to its association with type 2 diabetes and obesity. The more advanced form of this disease is known as nonalcoholic steatohepatitis (NASH). If left untreated, NASH can evolve to cirrhosis, the late stage of fibrosis. Once cirrhosis is established, patients are at increased risk of developing gastrointestinal bleeding, liver cancer and liver failure that may require transplantation. A liver... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2025
Locations: Centre Hospitalier de l'Université de Montréal, Montréal, Quebec
Conditions: Nonalcoholic Fatty Liver Disease (NAFLD), Nonalcoholic Steatohepatitis (NASH)
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Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
NCT04379596
Recruiting
DESTINY-Gastric03 will investigate the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of trastuzumab deruxtecan (T-DXd) alone or in combination with chemotherapy and/or immunotherapy in HER2-expressing advanced/metastatic gastric/gastroesophageal junction (GEJ) and esophageal adenocarcinoma patients. Study hypotheses: Combination of T-DXd with cytotoxic chemotherapy and/or immunotherapy administered to subjects at the recommended phase 2 dose will sho... Read More
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
03/14/2025
Locations: Research Site, Santa Monica, California +99 locations
Conditions: Gastric Cancer
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Postop Pain Management in Pituitary Tumour Patients
NCT06353529
Recruiting
To assess the benefit of using an additional nerve block during minimally invasive pituitary surgery, to improve pain management after surgery. The medication (Bupivacaine) or a placebo (saline) will be injected during surgery and patients will be asked about their level of pain at multiple time points in the first 24 hours following surgery. Some patients will be randomized to a third, sham group that do not receive any additional injection. The aim is to improve patient outcomes and reduce the... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/14/2025
Locations: Hamilton General Hospital, Hamilton, Ontario
Conditions: Pituitary, Pain, Postoperative
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Optimum Length of Catheter in the Epidural Space for Labor Analgesia in Non-obese Women: a Randomised Controlled Trial of 4 Cm Versus 5 Cm
NCT04946032
Recruiting
Epidural analgesia was introduced to the world of obstetrics in 1909 by Walter Stoeckel. Over the following 100 years it has developed to become the gold-standard for delivery of intra-partum analgesia, with between 60 and 75% of North American parturients receiving an epidural during their labor. Effective labor analgesia has been shown to improve maternal and fetal outcomes. One aspect of catheter insertion that has not been fully evaluated, and with very little recent work undertaken, is the... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
03/13/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Labor Pain
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The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty
NCT05800457
Recruiting
Osteoarthritis (OA) is the most common joint disease, causing severe pain due to joint inflammation (synovitis). While total knee arthroplasty (TKA) is commonly performed to reduce pain, 20% of patients are dissatisfied with their outcome post-surgery. This dissatisfaction is caused by persistent pain post-TKA due to synovitis that is not routinely removed during surgery. To address this problem, a synovectomy can be performed during TKA, which involves resecting the inflamed layer of tissue lin... Read More
Gender:
ALL
Ages:
Between 41 years and 80 years
Trial Updated:
03/13/2025
Locations: London Health Sciences Centre - University Hospital, London, Ontario
Conditions: Osteoarthritis, Knee
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