Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
NCT06233825
Recruiting
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma. The highest rates of skeletal muscle mass and strength loss occur during the 2-week post-surgery period, considered the early phase of outpatient recovery. Alternative to resistance exercise and pharmacology, nutritional intervention represents one strategy to combat skel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Queen's University, Kingston, Ontario
Conditions: Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
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Quantitative Ultrasound Techniques for Diagnosis of Nonalcoholic Steatohepatitis
NCT03572465
Recruiting
Nonalcoholic fatty liver disease is the most common liver disease in Western countries, due in large part to its association with type 2 diabetes and obesity. The more advanced form of this disease is known as nonalcoholic steatohepatitis (NASH). If left untreated, NASH can evolve to cirrhosis, the late stage of fibrosis. Once cirrhosis is established, patients are at increased risk of developing gastrointestinal bleeding, liver cancer and liver failure that may require transplantation. A liver... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2025
Locations: Centre Hospitalier de l'Université de Montréal, Montréal, Quebec
Conditions: Nonalcoholic Fatty Liver Disease (NAFLD), Nonalcoholic Steatohepatitis (NASH)
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Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
NCT04379596
Recruiting
DESTINY-Gastric03 will investigate the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of trastuzumab deruxtecan (T-DXd) alone or in combination with chemotherapy and/or immunotherapy in HER2-expressing advanced/metastatic gastric/gastroesophageal junction (GEJ) and esophageal adenocarcinoma patients. Study hypotheses: Combination of T-DXd with cytotoxic chemotherapy and/or immunotherapy administered to subjects at the recommended phase 2 dose will sho... Read More
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
03/14/2025
Locations: Research Site, Santa Monica, California +99 locations
Conditions: Gastric Cancer
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Postop Pain Management in Pituitary Tumour Patients
NCT06353529
Recruiting
To assess the benefit of using an additional nerve block during minimally invasive pituitary surgery, to improve pain management after surgery. The medication (Bupivacaine) or a placebo (saline) will be injected during surgery and patients will be asked about their level of pain at multiple time points in the first 24 hours following surgery. Some patients will be randomized to a third, sham group that do not receive any additional injection. The aim is to improve patient outcomes and reduce the... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/14/2025
Locations: Hamilton General Hospital, Hamilton, Ontario
Conditions: Pituitary, Pain, Postoperative
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Dissecting Host-microbiome Modifiers of Type 2 Diabetes Risk
NCT04579900
Recruiting
It is now well documented that changes in gut microbiota composition accompany obesity and type 2 diabetes (T2D) and contribute to low-grade inflammation, insulin resistance,and glucose intolerance. It is not yet clear if T2D predisposes the intestine to allow more microbial products or possibly live bacteria to subvert the gut mucosal barrier. However, it is known that hyperglycemia during T2D induces a more permissive gut barrier allowing increased penetration of microbes and their products in... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/13/2025
Locations: INAF, Université Laval, Québec, Quebec
Conditions: Type 2 Diabetes
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Optimum Length of Catheter in the Epidural Space for Labor Analgesia in Non-obese Women: a Randomised Controlled Trial of 4 Cm Versus 5 Cm
NCT04946032
Recruiting
Epidural analgesia was introduced to the world of obstetrics in 1909 by Walter Stoeckel. Over the following 100 years it has developed to become the gold-standard for delivery of intra-partum analgesia, with between 60 and 75% of North American parturients receiving an epidural during their labor. Effective labor analgesia has been shown to improve maternal and fetal outcomes. One aspect of catheter insertion that has not been fully evaluated, and with very little recent work undertaken, is the... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
03/13/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Labor Pain
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A Study of GSK5764227 in Participants With Advanced Solid Tumors
NCT06551142
Recruiting
The goal of this study is to assess the safety, tolerability, clinical activity and pharmacokinetics of GSK5764227. The study will also see how the levels of GSK5764227 will change over time at different dose amounts when administered alone and in combination with other medicines like carboplatin, cisplatin, atezolizumab, pembrolizumab, durvalumab, bevacizumab, cetuximab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: GSK Investigational Site, Denver, Colorado +13 locations
Conditions: Neoplasms
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Ablative Radiotherapy to Consolidate Maximal Systemic Response in Metastatic Prostate Cancer (ANCHOR-Prostate)
NCT05457699
Recruiting
A phase IIR cmRCT trial companion to PERa registry, investigating the merit of SABR consolidation in men with metastatic prostate cancer. 80 patients will be randomly selected to be offered experimental SABR based on PSMA-PET detected disease after maximal systemic response. The primary endpoint is the rate of FFS at 1 year. Patients will be stratified according to hormone sensitive vs resistant disease prior to randomisation.
Gender:
MALE
Ages:
All
Trial Updated:
03/13/2025
Locations: CRCHUM, Montreal, Quebec
Conditions: Prostate Cancer Metastatic
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The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty
NCT05800457
Recruiting
Osteoarthritis (OA) is the most common joint disease, causing severe pain due to joint inflammation (synovitis). While total knee arthroplasty (TKA) is commonly performed to reduce pain, 20% of patients are dissatisfied with their outcome post-surgery. This dissatisfaction is caused by persistent pain post-TKA due to synovitis that is not routinely removed during surgery. To address this problem, a synovectomy can be performed during TKA, which involves resecting the inflamed layer of tissue lin... Read More
Gender:
ALL
Ages:
Between 41 years and 80 years
Trial Updated:
03/13/2025
Locations: London Health Sciences Centre - University Hospital, London, Ontario
Conditions: Osteoarthritis, Knee
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Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis
NCT06103500
Recruiting
As antibiotic resistance increases globally, it becomes more difficult to select empiric antibiotic therapy, particularly in patients with sepsis who stand to benefit from early adequate treatment. In particular it is difficult for clinicians to balance antibiotic stewardship principles (the need to avoid unnecessary prescribing of antibiotics that have an excessively broad spectrum of activity that favour resistance development) and under treatment. The integration of multiple risk variables fo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Trillium Health Partners, Mississauga, Ontario +2 locations
Conditions: Sepsis, Bacterial Infections, Community-Acquired Infections, Hospital Infection
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Focal HDR Brachytherapy Boost to Stereotactic Radiotherapy
NCT04100174
Recruiting
To determine if fBT+sRT is superior to standard care in terms of urinary toxicity by having fewer patients experience a minimal important decline (MID) in urinary irritation/obstructive QoL
Gender:
MALE
Ages:
All
Trial Updated:
03/12/2025
Locations: Centre Hospitalier de l'Université de Montréal, Montréal, Quebec +1 locations
Conditions: Prostate Cancer
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Impact of Spaced ITBS on Plasticity in the Motor Cortex
NCT06735794
Recruiting
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity in healthy, right-handed individuals aged 18 to 50 years. Brain plasticity is the brain's ability to change through growth or reorganization. iTBS is a form of transcranial magnetic stimulation (TMS), where magnetic pulses are applied to the scalp using a coil. These pulses pass through the scalp, and can alter brain activity... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/12/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Healthy Control Subjects
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